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Residual Pulmonary Vascular Obstruction Following Mechanical Thrombectomy For Submassive Pulmonary Embolism: A Single-Center Analysis, Brian Stegman, Thom G. Dahle, Wade Schmidt, Jacob R. Dutcher, Tanya Glenz

Articles

Background:

Residual pulmonary vascular obstruction (RPVO) following pulmonary embolism (PE) is associated with residual dyspnea, recurrent venous thromboembolism, and chronic thromboembolic pulmonary hypertension. Historically, acute PE treated with anticoagulation alone results in high rates of significant RPVO. Contemporary treatment of submassive PE often involves catheter-based interventions, including mechanical thrombectomy (MT), although their relation to RPVO is not characterized. In this study, we aimed to evaluate the rate of greater than or equal to 10% RPVO in patients treated with MT.

Methods:

Twenty consecutive patients with submassive PE in a single center underwent MT and subsequent planar ventilation/perfusion scintigraphy scan at …

The Hydrodynamic Performance Of Duck Feet For Submerged Swimming Resembles Oars Rather Than Delta-Wings, Gal Ribak, Roi Gurka

Physics and Engineering Science

Waterfowl use webbed feet to swim underwater. It has been suggested that the triangular shape of the webbed foot functions as a lift-generating delta wing rather than a drag-generating oar. To test this idea, we studied the hydrodynamic characteristics of a diving duck’s (Aythya nyroca) foot. The foot’s time varying angles-of-attack (AoAs) during paddling were extracted from movies of ducks diving vertically in a water tank. Lift and drag coefficients of 3D-printed duck-foot models were measured as a function of AoA in a wind-tunnel; and the near-wake flow dynamics behind the foot model was characterized using particle image velocimetry (PIV) …

Assessing The Effectiveness Of Nuclear Security Training And Education In Ghana, Michael Nii Sanka Ansah, Boris Stepanov Pavlovich, Paul Atta Amoah, David Okoh Kpeglo, Simon Adu, Bright Kwame Afornu

International Journal of Nuclear Security

Growing attention is being given to nuclear power across several African countries, including in Ghana. The world is depending on nuclear energy as a reliable and efficient means of energy generation. Ghana as a country is developing nuclear energy; thus, equal attention must be directed toward nuclear safety and security. Ghana is gradually developing interest in and is devoting substantial required resources to educating and training on nuclear security to meet the standards required by international bodies. Institutions such as the Nuclear Safety and Security Centre and the School of Nuclear and Allied Sciences of the Ghana Atomic Energy Commission …

December 2023, Volume 19, Number 3, Winthrop University Archives And Special Collections

Retrospect: News from the Louise Pettus Archives and Special Collections at Winthrop University

No abstract provided.

The Hand That Nurtures, Alyssa Ferraro

The Prairie Light Review

No abstract provided.

To My Biological Father: A Pantoum, Wilda Morris

The Prairie Light Review

No abstract provided.

The Endoparasite Fauna Of Mesopredatory Mesopelagic Teleosts, Alexander U. Rayburn

All HCAS Student Capstones, Theses, and Dissertations

The ecology of the mesopelagic zone is an understudied area of the open ocean, with few diet studies even for dominant fish species. Since endoparasites are generally transmitted trophically, descriptions of the parasite communities within fishes can often provide additional insights on food web interactions. This project assesses the endoparasite faunal community of mesopredatory mesopelagic teleosts to better understand mesopelagic food webs in the South Atlantic Bight. Fishes in the Families Alepisauridae (lancetfishes), Gempylidae (snake mackerels), Bramidae (pomfrets), and Scombrolabracidae (longfin escolar) are frequent bycatch in the pelagic longline fishery targeting swordfish Xiphias gladius and thunnid tunas, yet the ecology …

Do Mesopelagic Fish Biomass Patterns Change In Response To Major Oceanographic Features In The Northern Gulf Of Mexico?, Ian M. Areford

All HCAS Student Capstones, Theses, and Dissertations

In recent years interest in mesopelagic fishes has grown due to their ecological significance and economic potential. A major outstanding question is how the assemblage is potentially structured by mesoscale (10 - 100s km) oceanographic features such as eddies, fronts, and riverine plumes. Mesoscale features are known to influence micronekton and zooplankton’s spatial distributions but data on individual mesopelagic fish species’ responses are limited. The Gulf of Mexico (GoM) is an area of particular interest due to its diverse mesopelagic fish assemblage, its well-defined mesoscale oceanographic features, its history of anthropogenic impacts such as oil spills, and its diverse mesopelagic …

From Becoming To Being: How Stem Teachers Develop Leadership Identities, Kelsey Quaisley, Wendy M. Smith, Brett A. Criswell, Rachel Funk, Anna Hutchinson

Secondary Education Faculty Publications

The development of STEM teacher leadership identity empowers K-12 teachers to make changes to improve teaching and learning. Identity development might not be productively supported in all school settings, however. Hence, external professional development programs should offer opportunities to supplement this identity development. We construct and propose a Can't-to-Becoming-to-Being model to describe STEM teacher leadership identity development as a progression of stages from weak to strong identity. Using interview data over two points in time with 127 STEM teacher leaders, we illustrate four stages of development: Can't, Can, Should, and Being. We also elucidate the conditions that teachers identify as …

Exploring The Mechanistic Effects Of Surface Characteristics On Uv254 And Bl405 Disinfection Efficacy, Castine Annastasia Bernardy

Doctoral Dissertations

The COVID-19 pandemic highlighted the need for more robust surface disinfection technologies. Photoinactivation efficacy for microbial pathogens and many surrogates has been well studied for water disinfection. However, there is a limited body of knowledge from research on surface disinfection applications of these technologies. The onset of the global pandemic resulted in a dramatic increase in surface disinfection devices being marketed to consumers, yet regulations for such devices have not been developed. This doctoral research studies the inactivation efficacy of two wavelengths, UV254 and BL405. The objective of this doctoral dissertation was to expand the body of knowledge required to …

Exploring Protein Function And Stability: Case Studies On Cryoprotection And Thermal Stability Of Antifreeze Proteins, Enzyme Inhibition Of Sars-Cov-2 Main Protease, And B. Subtilis Protein Stability, Katarina Jovic

Doctoral Dissertations

In this work, I have explored basic questions related to protein structure, function, and stability, which are critical for understanding the fundamental mechanisms of biology. The dissertation is divided into four chapters, which are different topics I have worked on. In Chapters 1 and 2, I will discuss my work on two different antifreeze proteins, in Chapter 3 my work on the main protease from SARS-CoV-2 is presented, while Chapter 4 details the characterization of protein stability of four B. subtilis proteins. While the projects are distinct from one another, they all contribute to deciphering the molecular basis of life …

Towards Improved Genomic Surveillance Of Organisms, Joseph L. Sevigny

Doctoral Dissertations

DNA and RNA sequencing is an indispensable tool for the surveillance and monitoring of organisms. Technological advances and research opportunities over the past several years have transformed and driven my research questions; from understanding the impacts of environmental perturbations on complex benthic communities, to tracking and understanding emerging pathogens like SARS-CoV-2. All of them revolve around the use of DNA sequencing to ask fundamental questions about our understanding genomes and their relationship to phenotype and the environment. The advent of sequencing-based characterization has revolutionized our approach to studying organismal communities on a large scale, offering the ability to analyze vast …

Understanding The Role Of Impounded Water Bodies In River Network Nutrient Exports In A Dynamic Landscape, Christopher Thomas Whitney

Doctoral Dissertations

Impounded water bodies are a significant component of aquatic networks and various forms have been studied extensively. However, knowledge gaps exist in the research on human-made dams and their reservoirs as well as beaver ponds as both uniquely affect water quality and nutrient exports in different ways. This study fills those knowledge gaps by investigating fluxes of all forms of dissolved nitrogen from small, human-made reservoirs at seasonal timescales. This study found that small reservoirs have a significant effect on nitrogen concentrations but this effect is seasonal and fluxes transported downstream are highly dependent on discharge. Removal of small dams …

Investigating Posttranslational Modifications Of Hsp90 And The Epichaperome In Embryonic Stem Cells, Seth William Mcnutt

Doctoral Dissertations

Heat shock protein 90 (Hsp90) is a highly conserved and essential molecular chaperone in eukaryotes. Through interactions with various co-chaperones, Hsp90 is able to adapt to meet the specific needs of a structurally and functionally diverse, but specific set of clienteles. The diversity of its clients makes it a key regulator of nearly all cellular processes, and it serves as a central hub for many different signaling networks. One of the major functions of the Hsp90 chaperone machinery is in the modulation of protein homeostasis, a protective function often exploited in cancer cells in order to buffer oncogenic mutations and …

A Global Gene Expression Approach To Exploring Rock Colonization By Blastococcus Saxobsidens, Ryan Patrick Wilmot

Doctoral Dissertations

Introduction: Blastococcus saxobsidens is an endolithic bacterium associated with biodegradation of stone monuments across the Mediterranean basin. Recently, strains of the bacterium have been isolated from high altitude deserts in Chile, volcanic glass in Iceland, and from masonry of several cultural heritage sites across Europe and the Americas. Blastococcus saxobsidens global dispersion has been linked to patterns of wind distributed dust particles. The physiology that this bacterium uses to colonize a wide range of rock types in such distinct locations has not been previously explored however. This project has established that B. saxobsidens colonizes and respires a variety of chemically …

Displaying Phenylalanine Ammonia Lyases On Bacillus Subtilis Spore Surface For The Treatment Of Phenylketonuria Through Oral Administration, Guo Wu

Doctoral Dissertations

Bacillus subtilis spores are formed in response to adverse conditions as a survival mechanism. These spores are in a dormant state and do not require any nutrients. Their DNA is wrapped with self-assembled multilayers of protective proteins. These spores are highly resistant to various harsh conditions. B. subtilis spores serve as a well-characterized model for studying endospore formation and have been developed as a platform system for displaying heterologous proteins of various functions. It has been demonstrated that proteins displayed on the spore surface can enhance their robustness and extend their shelf-life, including enzymes as robust biocatalysts and antigens as …

Lessons From Hiv, Boriana Marintcheva

Bridgewater Review

No abstract provided.

Understanding Riverine Plastic Accumulation Along An Urbanization And Spatial Gradient: A Plastics Study In The Ipswich River Watershed, Emily Kathryn Lever

Master's Theses and Capstones

Plastic pollution in marine and freshwater ecosystems is a pervasive issue on regional, national, and global scales. A portion of land-based plastics ends up in the world’s oceans through river transport; some land-based plastics are retained within the surface freshwater network. Little is known about how much plastic pollution entering the surface water network is stored vs. exported to oceans. We studied macro- and microplastic in a suburban coastal watershed, the Ipswich River Watershed of Massachusetts, USA in 2022 to gain a better understanding of plastic accumulation in sediments versus downstream flux during baseflow versus storms in streams of different …

Chemical And Biological Catalysis Using A Functionalized Fluorinated Phthalocyanine, Mary Chiọma Okorie

Seton Hall University Dissertations and Theses (ETDs)

Phthalocyanines, a class of photosensitizers that generate ¹O₂ using visible light, have been widely used in a variety of applications such as catalysis, solid-state materials, and photodynamic therapy. A 3^rd generation, namely functionalized fluorinated phthalocyanines, F₄₈H₇(COOH)PcMetal, containing a carboxylic acid “tail” allows the Pc to be anchored onto supports such as metal oxides, producing a new family of supported photocatalysts, F₄₈H₇(COOH)PcZn-Oxides.

These new materials photooxidize toxic thioethers mainly to less toxic sulfoxides using visible light and air, a genuine green chemistry pathway. The catalysts are robust and survive reactive …

Designing, Cloning, And Testing Genetically Engineered Metabolic Pathways To Produce Therapeutics In Gut Bacteria, Teresa Le

McNair Scholars Research Journal

No abstract provided.

The Potential Effects Of Ketosis Through Diet & Nutrition To Mitigate Cancer, Sandra Channeary Khoun

McNair Scholars Research Journal

No abstract provided.

Nuclear Argonaute Hrde-1 Is Required For Proper Development And Maturation In C. Elegans, Hadeel Zourkout

McNair Scholars Research Journal

No abstract provided.

Calorie Restriction Modulates The Transcription Of Genes Related To Stress Response And Longevity In Human Muscle: The Calerie Study, Jayanta Kumar Das, Nirad Banskota, Julián Candia, Michael E. Griswold, Melissa Orenduff, Rafael De Cabo, David L. Corcoran, Sai Krupa Das, Supriyo De, Kim Marie Huffman, Virginia B. Kraus, William E. Kraus, Corby K Martin, Susan B. Racette, Leanne M. Redman, Birgit Schilling, Daniel W Belsky, Luigi Ferrucci

Clinical Research Faculty Publications

The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by postponement of disease, preservation of function, and increased stress resistance. Whether CR elicits the same physiological and molecular responses in humans remains mostly unexplored. In the CALERIE study, 12% CR for 2 years in healthy humans induced minor losses of muscle mass (leg lean mass) without changes of muscle strength, but mechanisms for muscle quality preservation remained unclear. We performed high-depth RNA-Seq (387–618 million paired reads) on human vastus lateralis muscle biopsies collected from the CALERIE participants at baseline, 12- and 24-month follow-up from the 90 …

December 2023 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Crushability Analysis Of Immediate-Release Oral Tablets And Capsules Approved By Fda In 2020-2022, Kamaladdin Saei, Anne Schweighardt, Fang Zhao

Doctoral External Publications

Healthcare providers often need to explore dosage form options for patients who are unable to swallow whole tablets or capsules. Most newly approved immediate-release (IR) oral solid drugs carry a "do not crush" warning or similar language in their labeling due to the lack of supporting clinical data. A 2021 publication by Uttaro et al. presented a crushability analysis strategy for risk assessment and demonstrated its utility for the questionable drugs on the ISMP do-not-crush list. This study aimed to extend the crushability analysis to newly FDA-approved drugs.

School Social Work 238 Exam Preparation: Resources And Handouts, Leticia Villarreal Sosa, Tiffany Nelson, Brenda Coble-Lindsey, Annette Johnson, Giesela Grumbach

School of Social Work Faculty Publications

No abstract provided.

Rapid Reaction Studies On The Chemistry Of Flavin Oxidation In Urocanate Reductase, Niusha Delavari

Masters Theses

Urocanate reductase (UrdA) is a bacterial flavin-dependent enzyme that reduces urocanate to imidazole propionate, enabling bacteria to use urocanate as an alternative respiratory electron acceptor. Elevated serum levels of imidazole propionate are associated with the development of type 2 diabetes and, since UrdA is only present in humans in gut bacteria, this enzyme has emerged as a significant factor linking the health of the gut microbiome and the metabolic disorder insulin resistance. Here we investigated the chemistry of flavin oxidation by urocanate in the isolated FAD domain of UrdA (UrdA’) using anaerobic stopped-flow experiments at 4 °C. This analysis unveiled …

What Role Do Parents And Acculturation Play In Chinese Female International High School Students’ Mental Health?, You Wu

Doctoral Dissertations

This study examines the challenges and mental health issues faced by Chinese female international students in private Catholic female high schools in the U.S. It explores three main areas: the types of acculturation challenges students face, the impact of these challenges on their mental health, and the role of parental communication in shaping students' and parents' perceptions of acculturation and mental health. Using qualitative methods, the research involved interviews with nine students and five parents from a girls' Catholic high school in California. Data were collected via narrative-inspired Zoom interviews, and analyzed using phenomenological principles, focusing on understanding the lived …

Cultural Control Tactics For Managing Spotted Wing Drosophila, Drosophila Suzukii, In New Hampshire Highbush Blueberry, Catherine Doheny Coverdale

Master's Theses and Capstones

Spotted wing drosophila, Drosophila suzukii (Matsumura) (Diptera: Drosophilidae), is an economically important pest that damages small, soft-skinned fruits. Female spotted wing drosophila (SWD) have a heavily sclerotized, serrated ovipositor which allows them to lay their eggs in ripe and ripening fruits. Woven polyethylene weed mat has been reported to influence ambient temperature and relative humidity within blueberry canopies. There is a lack of context-specific evidence regarding the mechanisms impacting its efficacy and how it may interact with other control methods, like crop sanitizer sprays containing peroxyacetic acid (PAA) and hydrogen peroxide (HP).This study was a two-year, split-plot field experiment in …

Population Viability Analysis Of A Remnant New England Cottontail Population In Southern New Hampshire, Brett Ferry

Master's Theses and Capstones

ABSTRACT

Population Viability Analysis of a Remnant New England Cottontail Population in Southern New Hampshire

ByBrett Ferry University of New Hampshire, December 2023

Early successional forest in the northeastern United States provides habitat for a rich diversity of wildlife. Historically, weather events, beaver activity, and fires were continually creating a mosaic of early successional habitat. However, with modern land use very little early successional habitat is created, leading to the decline of the species’ that rely on it. New England cottontail (sylvilagus transitionalis) is an early successional obligate species whose population has been in decline since the mid-twentieth century. In …