Digital Commons Network^™

Selective Reduction Of Nitriles In The Presence Of Aromatic Nitro Groups, Esther Seoha Yoo, Dr. Michael Barbachyn

Summer Research

• Identify reliable aprotic reaction conditions for selective reduction of a nitrile in the presence of a nitro group. •
• Examine a range of nitrobenzonitriles and nitrophenyl acetonitriles to determine the scope of the methodology.

Speech Regulation And Tobacco Harm Reduction, Jonathan Adler, Jacob James Rich

Faculty Publications

Regulation of commercial speech is a major component of federal regulation of tobacco products. Since adoption of federal tobacco legislation, the Food and Drug Administration has asserted regulatory authority over ENDS and other vaping products as “tobacco products,” subjecting them to the same regulatory regime as traditional tobacco products even though such projects appear to pose less of a threat to public health. Such regulation, and the restriction on truthful speech in particular, may be having negative consequences for public health. Barring producers from informing consumers about the relative risks of vaping products and their potential to reduce smoking eliminates …

A Developmental Approach To Diversifying Neuroscience Through Effective Mentorship Practices: Perspectives On Cross-Identity Mentorship And A Critical Call To Action., Tanisha G Hill-Jarrett, Rowena Ng, Carlos Cardenas-Iniguez, Jemima Akinsanya, Ismary Blanco, Johnathan M Borland, James S Brown, Tameka Clemons, Adriana K Cushnie, Jacqueline Garcia, Brianna George, Cera W Hassinan, Timothy J Hines, Dan Landayan, Taylor A Mccorkle, Katherine R Meckel, Mariajose Metcalfe, Samantha A Montoya, Deborah K Rose, Desmond R Warren

Faculty Research 2023

Many early-career neuroscientists with diverse identities may not have mentors who are more advanced in the neuroscience pipeline and have a congruent identity due to historic biases, laws, and policies impacting access to education. Cross-identity mentoring relationships pose challenges and power imbalances that impact the retention of diverse early career neuroscientists, but also hold the potential for a mutually enriching and collaborative relationship that fosters the mentee's success. Additionally, the barriers faced by diverse mentees and their mentorship needs may evolve with career progression and require developmental considerations. This article provides perspectives on factors that impact cross-identity mentorship from individuals …

Whole Genome Resequencing Reveals Genetic Diversity And Selection Signatures Of Ethiopian Indigenous Cattle Adapted To Local Environments, Endashaw Terefe, Gurja Belay, Abdulfatai Tijjani, Jianlin Han, Oliver Hanotte

Faculty Research 2023

Cattle are among the most important domesticated bovid species in the world, of which Ethiopia possesses large populations adapted to different agro-ecologies and production systems. Though several molecular population genetic studies have been done on Ethiopian indigenous cattle, genomic diversity and selection signatures pertinent to adaptation to the different local environments have yet to be comprehensively characterized. Here, the whole genome sequences of 151 samples from 14 Ethiopian indigenous cattle populations were analyzed to assess genomic diversity and differentiation as well as signatures of positive selection (using Hp, iHS, FST, and XP-CLR) in comparison to Sudanese zebu, Asian zebu, Ankole, …

New Insight Into The Causes, Consequences, And Correction Of Hematopoietic Stem Cell Aging., Els Mansell, Dawn S Lin, Stephen J Loughran, Michael D Milsom, Jennifer J. Trowbridge

Faculty Research 2023

Aging of hematopoietic stem cells (HSCs) is characterized by lineage bias, increased clonal expansion, and functional decrease. At the molecular level, aged HSCs typically display metabolic dysregulation, upregulation of inflammatory pathways, and downregulation of DNA repair pathways. Cellular aging of HSCs, driven by cell-intrinsic and cell-extrinsic factors, causes a predisposition to anemia, adaptive immune compromise, myelodys, plasia, and malignancy. Most hematologic diseases are strongly associated with age. But what is the biological foundation for decreased fitness with age? And are there therapeutic windows to resolve age-related hematopoietic decline? These questions were the focus of the International Society for Experimental Hematology …

L-Cysteine Ethyl Ester Prevents And Reverses Acquired Physical Dependence On Morphine In Male Sprague Dawley Rats., James N Bates, Paulina M Getsy, Gregory A Coffee, Santhosh M Baby, Peter M Macfarlane, Yee-Hsee Hsieh, Zackery T Knauss, Jason A. Bubier, Devin Mueller, Stephen J Lewis

Faculty Research 2023

The molecular mechanisms underlying the acquisition of addiction/dependence on morphine may result from the ability of the opioid to diminish the transport of L-cysteine into neurons via inhibition of excitatory amino acid transporter 3 (EAA3). The objective of this study was to determine whether the co-administration of the cell-penetrant L-thiol ester, L-cysteine ethyl ester (L-CYSee), would reduce physical dependence on morphine in male Sprague Dawley rats. Injection of the opioid-receptor antagonist, naloxone HCl (NLX; 1.5 mg/kg, IP), elicited pronounced withdrawal phenomena in rats which received a subcutaneous depot of morphine (150 mg/kg) for 36 h and were receiving a continuous …

Repeated Allergen Exposure Induces Histaminergic Dysregulation And Depression-Like Behaviors In A Non-Anaphylactic Food Allergy Mouse Model, Danielle Germundson-Hermanson

Biomedical Sciences Posters and Presentations

▪ Food allergy is often comorbid with neuropsychiatric disorders such as anxiety1,2, depression1,2, OCD3, ADD/ADHD4, and autism5. ➢ The mechanism of how food allergy may impact brain function and behavior in certain allergic individuals has yet to be elucidated.

▪ Mast cells (MCs) are not only the effector cell of the hypersensitivity response but are also important in maintaining brain homeostasis6. ➢ MCs have been implicated in neuropsychiatric and neurodegenerative disorders such as multiple sclerosis7,8.

▪ We have previously found in a mouse model of cow’s milk allergy (CMA) that intracranial MC numbers9 and histamine 3 receptor (H3R)10 increased after …

Cortical Demyelination And Depression-Like Behavior Are Associated With Histaminergic Dysregulation In A Mouse Model Of Peripheral Inflammation, Danielle Germundson-Hermanson

Biomedical Sciences Posters and Presentations

▪ Demyelinating diseases of the central nervous system are increasing in prevalence world-wide1,2 and manifest as motor, behavioral, and/or cognitive defects3 . The etiology and pathophysiology of demyelinating diseases remain unclear.

▪ We have previously observed cortical demyelination in our mouse model of non-anaphylactic cow’s milk allergy4 . The demyelination was associated with depression-like behaviors and region-specific increases in brain histamine and H3 receptor (H3R) levels4,5 .

❖ The brain’s central histaminergic system is tightly controlled and regulates many behaviors. Additionally, signaling through H3R plays a crucial role in oligodendrocyte differentiation, and thus, demyelination and remyelination6 .

▪ We hypothesized …

Biochemistry And Molecular Biology Baccalaureate Degree Annual Program Outcomes Assessments, 2022-23, College Of Science And Mathematics, Wright State University

Annual Program Outcomes Assessments - All

This report reviews Wright State University's Biochemistry and Molecular Biology Baccalaureate Degree program for the 2022-2023 academic year.

Medical Laboratory Science Baccalaureate Degree Annual Program Outcomes Assessments, 2022-23, College Of Science And Mathematics, Wright State University

Annual Program Outcomes Assessments - All

This report reviews Wright State University's Medical Laboratory Science Baccalaureate Degree program for the 2022-2023 academic year.

Integrated Science Studies Baccalaureate Degree Annual Program Outcomes Assessments, 2022-23, Lake Campus, Wright State University

Annual Program Outcomes Assessments - All

This report reviews Wright State University's Integrated Science Studies Baccalaureate Degree program for the 2022-2023 academic year.

Biomedical Sciences Doctoral Degree Annual Program Outcomes Assessments, 2022-23, College Of Science And Mathematics, Wright State University

Annual Program Outcomes Assessments - All

This report reviews Wright State University's Biomedical Sciences Doctoral Degree program for the 2022-2023 academic year.

Comparison Of Water Column Properties Derived From An Autonomous Underwater Vehicle And Satellite Based Sources In Lake Michigan, David Bennion

Master's Theses and Doctoral Dissertations

Autonomous underwater vehicles (AUVs) are an emerging technology increasingly being employed in geoscience and ecosystem research in the Great Lakes, capitalizing on their ability to sample large areas fitted with a variety of sensors. Previous to AUV use, chlorophyll measurements were either collected at discrete locations accessed by boats or derived from satellite remote sensing data. An advantage of AUVs is the ability to detect the presence of subsurface formations such as a deep chlorophyll layer or directly measure features such as the extent of the photic zone, which provides the opportunity to compare these in situ measured features to …

Investigating Michigan’S Skilled Construction Laborer Shortage Within The Great Lakes Region, Jennifer E. Russell

Master's Theses and Doctoral Dissertations

The construction industry has been facing a decline in skilled trade labor for decades. This study asks three overarching questions: (a) What are the causes and influencing factors of Michigan’s skilled construction laborer shortage? (b) How are Michigan stakeholders in the Great Lakes Region remedying the shortage? (c) What new solutions can be implemented to remedy Michigan’s skilled construction laborer shortage? A literature review was conducted to identify causes, influencing factors, and research gaps. Closed surveys questioning 69 construction project managers and 101 skilled trade laborers in Michigan were conducted online and on construction sites. A quantitative analysis of the …

Unity House Interviews 2, Ryan Rivera, Ratia Ruangsuwana Collins, Saveena Dhall, Julie Leung, Nicole Mcneil Ford

Alumni Oral History Project

No abstract provided.

General Theory Of Information, Digital Genome, Large Language Models, And Medical Knowledge-Driven Digital Assistant, W. Patrick Kelly, Francesco Coccaro, Rao Mikkilineni

Barowsky School of Business | Faculty Scholarship

Recent advances in large language models, our understanding of the general theory of information, and the availability of new approaches to building self-regulating domain-specific software are driving the creation of next-generation knowledge-driven digital assistants to improve the efficiency, resiliency, and scalability of various business processes while fulfilling the functional requirements addressing a specific business problem. Here, we describe the implementation of a medical-knowledge-based digital assistant that uses medical knowledge derived from various sources including the large language models and assists the early medical diagnosis process by reducing the knowledge gap between the patient and medical professionals involved in the process.

Prenatal Buprenorphine Exposure Reduces Expression Of Myelin Proteins In Neonatal Longs-Evans Rat, Christopher James Grahe

Theses, Dissertations and Capstones

In the USA and especially in WV, there has been a surge in the rise of opioid use disorder (OUD), and with it a rise in neonatal abstinence syndrome (NAS). What makes this rise in NAS so unfortunate is that the Medications for OUD (MOUD) do not prevent the development of NAS. Although the relationship between MOUD and NAS is still unclear, it is thought that buprenorphine, one of the main substances used to treat OUD in pregnant women, may feed into the development of NAS, which may affect mental and physiological development and cause other health problems. Via understanding …

Life Skills Intervention For Formerly Incarcerated Individuals At Maricopa Reentry Center, Dalenna Bellum

OT Student Capstones

The rates of incarceration quickly rose in the United States in the late 1900’s in response to change in legislation in favor of more tough on crime movements and policy. In addition to these movements and other social, environmental, and demographic factors, certain groups of individuals faced increased risk for incarceration and increased challenges before, during, and after incarceration. The purpose of this doctoral capstone experience and report is to explore challenges during community reentry after incarceration that can lead to re-arrest, or recidivism. This is a crucial time because without the appropriate tools, resources, and supports, the individual is …

Swipe Right Into A Disciplinary Hearing: How The Use Of Dating Apps Could Earn An Attorney More Than A Bad First Date, Zachary S. Aman

Catholic University Journal of Law and Technology

The Model Rules of Professional Conduct seek to police the conduct of attorneys. Each jurisdiction adopts its own rules of professional conduct to apply to the attorneys licensed within it. Notably, the model rules prohibit any sexual relationship between the attorney and client unless that relationship precedes the attorney-client relationship. Traditionally, defining a "sexual relationship" was simple, particularly if the attorney and client engaged in sexual intercourse. The introduction of dating apps, however, has blurred the line.

This article outlines the inherent risks of attorneys using dating apps at a time when most newly-licensed attorneys make up the majority of …

Establishing The Legal Framework To Regulate Quantum Computing Technology, Kaya Derose

Catholic University Journal of Law and Technology

No abstract provided.

Slow Mohs For Sebaceous Carcinoma Of The Scalp, Heather Kopecky, Angela Rosenburg, Brett Thomas, Richard Miller

West Florida Division GME Research Day 2023

No abstract provided.

Cancer Immunotherapy: A Breakthrough In Patient Care, Abdou-Samad Kone, Nour El Imane Issam Salah, Amina Ghouzlani, Abdallah Badou

Health Sciences

Cancer is one of the world's leading causes of death. Conventional therapies, such as surgical resection, radiotherapy, and chemotherapy, have improved patient management and have shown overwhelming progress. However, the incidence and mortality rates among cancer patients are still extremely high, at approximately 20,5 % and 10,6 % for both sexes, respectively. This may be due to the heterogeneity of tumors, their special microenvironment, and the development of resistance to certain conventional therapies. The concept of immunotherapy provided a new perspective on patient treatment. The interaction of tumor cells with their microenvironment depends on different factors and conditions that promote …

Annual Financial Report, 2022-2023, University Of Arkansas, Fayetteville

Annual Financial Report

No abstract provided.

Veterinary Medicine And The Covid-19 Pandemic: An International, Interdisciplinary Study Of A Globalwicked Problem, Daniella Fedak-Lengel

International ResearchScape Journal

Building on field research in Costa Rica and Belize, this study analyzes environmental and endangered animal protection policies, rights, and practices in Central America, and assesses impacts of veterinary science and conservation biology on animal welfare concerns. Informed by the recent surge in awareness regarding the spread of zoonotic diseases, given COVID-19, the study analyzes Manis javanica and the impact of illegal trafficking of this critically endangered animal. The project theorizes if awareness of zoonotic disease transmission, especially during a global pandemic, could be key to reducing sales, legal or illegal, of wild animals in order to mitigate zoonotic infection …

Racial, Ethnic, And Sex Diversity Trends In Health Professions Programs From Applicants To Graduates, Daniel Majerczyk, Erin M. Behnen, David J. Weldon, Roy Kanbar, Yolanda M. Hardy, Stanley K. Matsuda, Karen L. Hardinger, Farid G. Khalafalla

Funded Scholarship

Importance Diversity is an essential element of an effective health care system. A key to developing a diverse workforce is establishing a diverse student population in health professions programs.

Objective To examine the diversity of students in Doctor of Medicine (MD), Doctor of Osteopathic Medicine (DO), Doctor of Dental Surgery (DDS), Doctor of Dental Medicine (DMD), and Doctor of Pharmacy (PharmD) programs with emphasis on the trends of underrepresented minoritized groups (American Indian or Alaska Native, Black or African American, Hispanic or Latino, and Native Hawaiian or Other Pacific Islander) and sex relative to the overall age-adjusted US population.

Design, …

Editorial: Targeting Glucose Metabolism In Cancer Immunity And Immunotherapy., Olivier Feron, Chih-Hao Chang, Frédérique Végran

Faculty Research 2023

No abstract provided.

Resilience Theory And Coerced Resilience In Agriculture, S. M. Sundstrom, D. G. Angeler, C. R. Allen

School of Natural Resources: Documents and Reviews

No abstract provided.

Storms And Ph Of Dam Releases Affects Downstream Phosphorus Cycling In An Arid Regulated River, B. R. Deemer, R. H. Reibold, A. Fatta, J. R. Corman, C. B. Yackulic, S. C. Reed

School of Natural Resources: Documents and Reviews

No abstract provided.

Modified Tracer Gas Injection For Measuring Stream Gas Exchange Velocity In The Presence Of Significant Temperature Variation, C. R. Jensen, D. P. Genereux, T. E. Gilmore, D. K. Solomon

School of Natural Resources: Documents and Reviews

No abstract provided.

Characterization Of Particulate Size Distributions And Water-Soluble Ions Measured At A Broiler Farm, P. J. Silva, T. Cress, R. Drover, C. Michael, G. Docekal, P. Larkin, A. Godoy, D. A. Cavero, C. Sin, J. Waites, Rezaul Mamood, M. Cohron, K. L. Purvis-Roberts

School of Natural Resources: Documents and Reviews

No abstract provided.