Digital Commons Network^™

Use Of Serial Smartphone-Based Assessments To Characterize Diverse Neuropsychiatric Symptom Trajectories In A Large Trauma Survivor Cohort, Francesca L Beaudoin, Xinming An, Archana Basu, Yinyao Ji, Mochuan Liu, Ronald C Kessler, Robert F Doughtery, Donglin Zeng, Kenneth A Bollen, Stacey L House, Jennifer S Stevens, Thomas C Neylan, Gari D Clifford, Tanja Jovanovic, Sarah D Linnstaedt, Laura T Germine, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Michael C Kurz, Robert A Swor, Vishnu P Murty, Meghan E Mcgrath, Lauren A Hudak, Jose L Pascual, Elizabeth M Datner, Anna Marie Chang, Claire Pearson, David A Peak, Roland C Merchant, Robert M Domeier, Niels K Rathlev, Brian J O' Neil, Paulina Sergot, Leon D Sanchez, Steven E Bruce, Justin T Baker, Jutta Joormann, Mark W Miller, Robert H Pietrzak, Deanna M Barch, Diego A Pizzagalli, John F Sheridan, Jordan W Smoller, Steven E Harte, James M Elliott, Karestan C Koenen, Kerry J Ressler, Samuel A Mclean

Department of Emergency Medicine Faculty Papers

The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied sample of motor vehicle collision (MVC) survivors. More than two thousand MVC survivors were enrolled in the emergency department (ED) and completed a rotating battery of brief smartphone-based surveys over a 2-month period. Measurement models developed from survey item responses were used in latent growth curve/mixture modeling to characterize homogeneous symptom trajectories. Associations between individual trajectories and pre-trauma and peritraumatic characteristics and traditional outcomes were compared, along …

Echinococcus Multilocularis Calreticulin Interferes With C1q-Mediated Complement Activation, Siqi Xian, Lujuan Chen, Yan Yan, Jianfang Chen, Guixia Yu, Yuxiao Shao, Bin Zhan, Yanhai Wang, Limei Zhao

Faculty, Staff and Students Publications

As a zoonotic disease caused by Echinococcus multilocularis larvae, alveolar echinococcosis (AE) is one of the most severe forms of parasitic infection. Over a long evolutional process E. multilocularis has developed complex strategies to escape host immune attack and survive within a host. However, the mechanisms underlying immune evasion remain unclear. Here we investigated the binding activity of E. multilocularis calreticulin (EmCRT), a highly conserved Ca2+-binding protein, to human complement C1q and its ability to inhibit classical complement activation. ELISA, Far Western blotting and immunoprecipitation results demonstrated that both recombinant and natural EmCRTs bound to human C1q, …

Silencing Mir-146a-5p Protects Against Injury-Induced Osteoarthritis In Mice, Haocheng Qin, Cuicui Wang, Yonghua He, Aiwu Lu, Tiandao Li, Bo Zhang, Jie Shen

2020-Current year OA Pubs

Osteoarthritis (OA), the most prevalent joint disease and the leading cause of disability, remains an incurable disease largely because the etiology and pathogenesis underlying this degenerative process are poorly understood. Low-grade inflammation within joints is a well-established factor that disturbs joint homeostasis and leads to an imbalance between anabolic and catabolic processes in articular cartilage; however, the complexity of the network between inflammatory factors that often involves positive and negative feedback loops makes current anti-cytokine therapy ineffective. MicroRNAs (miRNAs) have emerged as key regulators to control inflammation, and aberrant miRNAs expression has recently been linked to OA pathophysiology. In the …

Commercialization Of Separated Human Body Parts - Unpacking Instrumentalization Approach, Arseny Shevelev, Georgy Shevelev

Pace International Law Review

The principle of non-commercialization, which prohibits trade in separated human body parts, has long been firmly embedded in many European legal orders and has become an integral part of them. However, many new uses for human biomaterials have now been discovered, and the need for them has reached a historical climax. This paper aims to explain the main tenets of non-commercialization theory, including such principles as human dignity and need to protect human’s health, and to show that these categories have so far been understood in a very one-sided and visceral way, and largely in contradiction to their true spirit. …

The Future Of Pandemics: Land Use Controls As Means Of Preventing Zoonotic Disease, Bailey Andree

Pace International Law Review

Zoonotic diseases are increasing in frequency as climate change worsens around the world, with the recent COVID-19 pandemic highlighting the inadequate mechanisms in place to counteract disease spread. This article reviews various zoonotic diseases and their patterns of spread, highlighting land use change as the key driver of disease to demonstrate the need for legal intervention. International land use law is a little-developed subsect of environmental law that holds the key to combating this disease spread, and this article proposes solutions through this legal lens. Land use techniques which may be used to combat disease spread include conservation laws, setback …

Lychas Jakli Sp. N. (Scorpiones: Buthidae) From Indonesia, František Kovařík

Euscorpius

A new species Lychas jakli sp. n. (Scorpiones: Buthidae) is described from Indonesia, fully illustrated with color photos showing its morphology and habitus. A new synonymy is proposed: Lychas kotao Lourenço, 2020 = Lychas mucronatus (Fabricius, 1798), syn. n.

Traditional Plants That Are Utilized To Treat Urinary Tract Infections: A Review, Rasha Hadi Saleh, Aseel Mohammad Omran, Rafah S. Almuttairi Alhilla

Maaen Journal for Medical Sciences

Among the most serious problems affecting public health is urinary tract infection (UTI). There are several parts of the urinary tract affected by this type of inflammation and affects women more frequently than men. As the antibacterial resistance problem is growing in urological medicine, there is a increasing and a continuing requirement to add antimicrobial medication which could be from medicinal herbs in regulatory UTIs. Since the beginning of civilization, medicinal plants have been an integral element of human society in the fight against diseases. For the aim of reducing costs, increasing the effectiveness of treatment and eliminating the side …

Association Of Breast Cancer With Single Nucleotide Polymorphism Of Cyp2c9 Gene For Women Patients In Baghdad, Iraq, Mohammed R. Al-Lami, Falah S. Al-Fartusie, Dheaa Sh. Zageer

Al-Bahir

Breast cancer (BC) is a very varied disease, with several subtypes that exhibit different biological, molecular, and clinical characteristics. Standard information on tumor biology and clinicopathology can be identified by gene expression profile; have provided enhanced prognostic and predictive information. This study included 37 patients suffering from breast cancer and 15 healthy subjects. DNA has been extracted from all samples and then real-time PCR has been performed to analyze the genotyping of Rs1799853. The results showed higher frequency of CT genotype in the control subjects than the patients (73.3 and 43.2, respectively) and this difference was significant (0dd= 0.28, p-value= …

Exploring Grit In Exemplary School Superintendents, Denise Jaramillo

Dissertations

Purpose: The purpose of this phenomenological study was to identify and describe how exemplary superintendents use five principles associated with grit (courage, conscientiousness, long-term goals, resilience, and excellence versus perfection) to accomplish extraordinary results in their organizations.

Methodology: This qualitative study was part of a larger thematic study conducted by nine doctoral candidates under the supervision of three University of Massachusetts Global faculty. The study used a phenomenological design to identify and describe how exemplary superintendents use five principles associated with grit to accomplish extraordinary results. Data were gathered through a combination of eight semistructured interviews, related observations, and a …

Tuning Shear Thinning Factors Of 3d Bio-Printable Hydrogels Using Short Fiber, Slesha Tuladhar, Scott Clark, Ahasan Habib

New Hampshire EPSCoR

Among various available 3D bioprinting techniques, extrusion-based three-dimensional (3D) bioprinting allows the deposition of cell-laden bioink, ensuring predefined scaffold architecture that may offer living tissue regeneration. With a combination of unique characteristics such as biocompatibility, less cell toxicity, and high water content, natural hydrogels are a great candidate for bioink formulation for the extrusion-based 3D bioprinting process. However, due to its low mechanical integrity, hydrogel faces a common challenge in maintaining structural integrity. To tackle this challenge, the rheological properties, specifically the shear thinning behavior (reduction of viscosity with increasing the applied load/shear rate on hydrogels) of a set of …

Medical School Watercooler Newsletter - January 6, 2023, Lindsey Lyle

Watercooler Newsletter

This is the January 6, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Williams Hogue named Future Trauma Leader
• COM faculty, alumni included in Mobile Bay's 2023 40 Under 40 class
• Scalici to present on ovarian carcinogenesis
• Meet a Med Student: AK Porter

Survival Rates Of Band‐Tailed Pigeons Estimated Using Passive Integrated Transponder Tags, Daniel P. Collins, Guthrie S. Zimmerman, Scott A. Carleton, William L. Kendall, Christopher L. Coxen

United States Fish and Wildlife Service: Publications

Obtaining survival estimates on the Interior population of band-tailed pigeons (Patagioenas fasciata) is challenging because they are trap shy, but the joint use of passive integrated transponder (PIT) tags and bands is a potential solution. We investigated the use of PIT tags to passively recapture band‐tailed pigeon at 3 locations in New Mexico, USA, to estimate survival. From 2013–2015, we captured, banded, and marked >600 individual band‐tailed pigeons with PIT tags. To estimate annual survival rates, we used a Barker multi‐state joint live and dead encounters and resighting model. Survival models excluding transience had survival estimates across site, …

Pdcm Finder: An Open Global Research Platform For Patient-Derived Cancer Models., Zinaida Perova, Mauricio Martinez, Tushar Mandloi, Federico Lopez Gomez, Csaba Halmagyi, Alex Follette, Jeremy Mason, Steven Neuhauser, Dale A. Begley, Debra M Krupke, Carol J Bult, Helen Parkinson, Tudor Groza

Faculty Research 2023

PDCM Finder (www.cancermodels.org) is a cancer research platform that aggregates clinical, genomic and functional data from patient-derived xenografts, organoids and cell lines. It was launched in April 2022 as a successor of the PDX Finder portal, which focused solely on patient-derived xenograft models. Currently the portal has over 6200 models across 13 cancer types, including rare paediatric models (17%) and models from minority ethnic backgrounds (33%), making it the largest free to consumer and open access resource of this kind. The PDCM Finder standardises, harmonises and integrates the complex and diverse data associated with PDCMs for the cancer community and …

Mouse Phenome Database: Towards A More Fair-Compliant And Trust-Worthy Data Repository And Tool Suite For Phenotypes And Genotypes., Molly A. Bogue, Robyn L Ball, Vivek M. Philip, David O Walton, Matthew H Dunn, Georgi Kolishovski, Anna Lamoureux, Matthew Gerring, Hongping Liang, Jake Emerson, Timothy M Stearns, Hao He, Gaurab Mukherjee, John Bluis, Sejal Desai, Beth A. Sundberg, Beena Kadakkuzha, Govindarajan Kunde-Ramamoorthy, Elissa J Chesler

Faculty Research 2023

The Mouse Phenome Database (MPD; https://phenome.jax.org; RRID:SCR_003212), supported by the US National Institutes of Health, is a Biomedical Data Repository listed in the Trans-NIH Biomedical Informatics Coordinating Committee registry. As an increasingly FAIR-compliant and TRUST-worthy data repository, MPD accepts phenotype and genotype data from mouse experiments and curates, organizes, integrates, archives, and distributes those data using community standards. Data are accompanied by rich metadata, including widely used ontologies and detailed protocols. Data are from all over the world and represent genetic, behavioral, morphological, and physiological disease-related characteristics in mice at baseline or those exposed to drugs or other treatments. MPD …

Full Issue: Fall 2019

DePaul Magazine

This issue of DePaul Magazine announces the establishment of The Grace School of Applied Diplomacy in the College of Liberal Arts and Social Sciences. Learn more about transprofessional diplomacy and this exciting new endeavor in the cover story "Expanding the Borders of Diplomacy."

Thirteen New Species Of Butterflies (Lepidoptera: Hesperiidae) From Texas, Jing Zhang, Qian Cong, Nick V. Grishin

Insecta Mundi

Analyses of whole genomic shotgun datasets, COI barcodes, morphology, and historical literature suggest that the following 13 butterfly species from the family Hesperiidae (Lepidoptera: Papilionoidea) in Texas, USA are distinct from their closest named relatives and therefore are described as new (type localities are given in parenthesis): Spicauda atelis Grishin, new species (Hidalgo Co., Mission), Urbanus (Urbanus) rickardi Grishin, new species (Hidalgo Co., nr. Madero), Urbanus (Urbanus) oplerorum Grishin, new spe­cies (Hidalgo Co., Mission/Madero), Telegonus tsongae Grishin, new species (Starr Co., Roma), Autochton caballo Grishin, new species (Hidalgo Co., 6 mi W of Hidalgo), Epargyreus fractigutta …

Taxonomic Notes On The Luciolinae (Coleoptera: Lampyridae), Oliver Keller, Lesley Ballantyne

Insecta Mundi

Several nomenclatural changes for taxa in the firefly subfamily Luciolinae (Coleoptera: Lampyri­dae) are proposed. Evidence is presented to correct the year of description for Luciola dregei Motschulsky 1853 to Motschulsky 1854 when the name was ratified. We correct the authorities and years of descriptions for type species designations for the genera Delopleurus Motschulsky, 1853, and Delopyrus Motschulsky, 1853 to Motschulsky 1854 for both. All remaining taxa described as variations in the subfamily Luciolinae by McDermott (1966), are evaluated to subspecies with their availability determined based on ICZN (1999) Article 45.6.

New Host And Distribution Records Plus Additional Notes For North American Species Of Chrysobothris Eschscholtz (Coleoptera: Buprestidae), With Designation Of A Lectotype For Chrysobothris Vulcanica Leconte, 1861, Richard L. Westcott

Insecta Mundi

New distribution and host records plus additional notes are provided for North American spe­cies in the genus Chrysobothris Eschscholtz (Coleoptera: Buprestidae). Forty-one species are treated. The occurrence of Chrysobothris bicolor Horn in the USA is refuted. Chrysobothris breviloboides Barr is newly synonymized with Chrysobothris breviloba Fall. The southernmost record for Chrysobothris piuta Wick­ham, from Baja California, Mexico, is established. A specimen of the Argentinian Chrysobothris rugosa Gory and Laporte labeled from Florida is reported. A lectotype for Chrysobothris vulcanica LeConte is newly designated.

Temperature Fluctuation Alters Optimal Predator Community Composition For Anticipated Biological Control, Amanda N. Laubmeier, Nusrat Tabassum, Brigitte Tenhumberg

School of Biological Sciences: Faculty Publications

Alongside pesticides and specialist predators, natural communities of generalist beetle and spider predators play an important role in suppressing agricultural pests. However, the predation pressure of natural communities can be unpredictable. Overall predation pressure is influenced by a dense network of potential intraguild interactions, which are further shaped by species traits and environmental factors. Understanding how these different influences combine to impact pest control is especially important in the context of changing global temperatures. Recent empirical studies have demonstrated that the foraging behavior of arthropod predators is influenced by an interaction between temperature and predator body size. To explore the …

The Association Of Blood Ctdna Levels To Mutations Of Marker Genes In Colorectal Cancer, Fei Bai, Qian Du, Qingliang Zou, Lin Xu, Wei Dong, Xinlin Lv, Xiaorong Han, Huijun Zhou, Chi Zhang, Tao Lu

School of Biological Sciences: Faculty Publications

Background: Colorectal cancer (CRC) is a deadly and commonly diagnosed cancer. Cell‐free circulating tumor DNAs (ctDNA) have been used in the diagnosis and treatment of CRC, but there are open questions about the relationship between ctDNAs and CRC. Although mutations of genes detected by ctDNA in CRC have been studied, the quantitative relationship between ctDNA mutations and ctDNA concentration has not been addressed.

Aims: We hypothesized that there was an association between mutations of genes identified in ctDNAs and ctDNA concentration. His study examined this association in a population of CRC patients.

Methods: In 85 CRC patients, …

Full Issue: Fall 2018

DePaul Magazine

DePaul's new president, A. Gabriel Esteban, PhD, and his wife, Jo, talk about their lives and their first year at DePaul in this issue of DePaul Magazine. Discover their favorite places in Chicago in "The Road to DePaul."

Mouse Pancreatic Peptide Hormones Probed At The Sub-Single-Islet Level: The Effects Of Acute Corticosterone Treatment, Aleksandra Antevska, Connor C. Long, Samuel D. Dupuy, J. Jason Collier, Michael D. Karlstad, Thanh D. Do

Division of Basic Science Faculty Publications

We combine liquid chromatography coupled with ion mobility spectrometry-mass spectrometry to elucidate how short exposure to corticosterone (Cort) alters the output of mouse pancreatic islet hormones. The workflow enables the robust separation of mouse insulin 1 (Ins1) and insulin 2 (Ins2) and the detection of major islet hormones in a homogenate equivalent to 100-150 islet cells. We show that Ins2 has a unique structure and is degraded much faster than Ins1. Further investigation indicates that Ins2 may populate both T and R states, whereas Ins1 may not. The assemblies of Ins1’s B-chain also introduce more structural heterogeneity than Ins2. Collectively, …

The Evolution Of Life History Traits And Their Thermal Plasticity In Daphnia, Larry L. Bowman Jr., David M. Post

ETSU Faculty Works

Few studies have explored the relative strength of ecogeographic versus lineage-specific effects on a global scale, particularly for poikilotherms, those organisms whose internal temperature varies with their environment. Here, we compile a global dataset of life history traits in Daphnia, at the species-and population-level, and use those data to parse the relative influences of lineage-specific effects and climate. We also compare the thermal response (plasticity) of life history traits and their dependence on climate, temperature, precipitation, and latitude. We found that the mode of evolution for life history traits varies but that the thermal response of life history traits most …

Design And Synthesis Of Substituted N,3,3-Triphenylpropanamide And 1-Benzhydryl-N-Phenylazetidine-3-Carboxamide Analogs And Their Biological Evaluation, Michael Dorogan

Theses and Dissertations

As D₁R agonism has significant implications in the treatment of cognitive deficits, we sought to develop novel D₁R PAMs, through the derigidification of BMS D₁R PAM hit compound. While we were able to synthesize derigidified analogs of the BMS hit compound, derigidification did not produce active D₁R ligands.

Realisms And The Body After War: Document, Truth, And Critique In Postrevolutionary Mexico And Weimar Germany, Eliana Blechman

Theses and Dissertations

This thesis examines realisms and representations of the body in postrevolutionary Mexico, using the critical framework surrounding Neue Sachlichkeit and post-World War I Weimar society as a comparative model. Through imagery of soldiers, women, and class disparity, artists utilized realisms to relay record, suggest truth, and create criticism.

Does Gender Matter? Gendered Relations In The Recording Studios, Diane Wong

Theses and Dissertations

Only 8.6% of all recording engineers currently employed in the United States are women. To understand the influence of a woman’s gender in their recording career, this study presents their experiences from multiple angles – the recording studio business, women engineers’ obstacles, the recording education pipeline, and diversity and inclusion in the industry.

The Case Of The Disappearing Owner: Do Dogs Show Behavioral Evidence Of Violation Of Expectation?, Rita Kanagat

Theses and Dissertations

The What the Fluff challenge became a series of viral YouTube videos that started in 2018. In the videos, a person stood behind a blanket in a doorway in front of their dog and lifted and lowered the blanket revealing and obscuring themselves, and finally disappearing with a final blanket drop. The dogs’ reactions were varied but were suggestive of a violation of expectation response. We conducted a community science study that employed methodologies consistent with the What the Fluff Challenge paradigm that were conducted in the owners’ homes with their dogs. Each owner was required to run a control …

Skinks Of Oceania, New Guinea, And Eastern Wallacea: An Underexplored Biodiversity Hotspot, Alex Slavenko, Allen Allison, Christopher C. Austin, Aaron M. Bauer, Rafe M. Brown, Robert N. Fisher, Ivan Ineich, Bulisa Iova, Benjamin R. Karin, Fred Kraus, Sven Mecke, Shai Meiri, Clare Morrison, Paul M. Oliver, Mark O. Shea, Jonathan Q. Richmond, Glenn M. Shea, Oliver J.S. Tallowin, David G. Chapple

Faculty Publications

Context. Skinks comprise the dominant component of the terrestrial vertebrate fauna in Oceania, New Guinea, and Eastern Wallacea (ONGEW). However, knowledge of their diversity is incomplete, and their conservation needs are poorly understood. Aims. To explore the diversity and threat status of the skinks of ONGEW and identify knowledge gaps and conservation needs. Methods. We compiled a list of all skink species occurring in the region and their threat categories designated by the International Union for Conservation of Nature. We used available genetic sequences deposited in the National Center for Biotechnology Information's GenBank to generate a phylogeny of the region’s …

Full Issue: Summer 2019

DePaul Magazine

In this issue of DePaul Magazine, the cover story profiles Scott Ellis, a 1978 graduate of The Theatre School who has made a successful career as a theatre and television director. Learn about his work on the Broadway musical "Tootsie" and more in "Born to Direct."

Modeling Coho Salmon (Oncorhynchus Kisutch) Population Response To Streamflow And Water Temperature Extremes, J. Ryan Bellmore, Christopher Sergeant, Rebecca Bellmore, Jeffery Falke, Jason Fellman

Faculty, Staff, and Students

Models that assess the vulnerability of freshwater species to shifting environmental conditions do not always account for short-duration extremes, which are increasingly common. Life cycle models for Pacific salmon (Oncorhynchus spp.) generally focus on average conditions that fish experience during each life stage, yet many floods, low flows, and elevated water temperatures only last days to weeks. We developed a process-based life cycle model that links coho salmon (Oncorhynchus kisutch) abundance to daily streamflow and thermal regimes to assess: (1) “How does salmon abundance respond to short-duration floods, low flows, and high temperatures in glacier-, snow-, and rain-fed streams?” and …