Digital Commons Network^™

Defining Treatment-Resistant Bipolar Depression: Recommendations From The Isbd Task Force, Eduard Vieta, Roger S Mcintyre, Trisha Suppes, Tamsyn E Van Rheenen, Balwinder Singh, Kamilla Woznica Miskowiak, Allan H Young, Lakshmi N Yatham, Kyooseob Ha, Michael Berk, Holly A Swartz, Chantal Henry, Maja Pantovic Stefanovic, Gerard Anmella Diaz, Aysegul Ozerdem, Wiesław J Cubała, Diego Hidalgo-Mazzei, Mauricio Tohen, Isabella Pacchiarotti, Paula Villela Nunes, Carlos Lopez-Jaramillo, Ana Gonzalez-Pinto, Paolo Brambilla, Robert Post, Jair C Soares, Michael Bauer, Ana C Andreazza, Xavier Justes Fradera, Montserrat Cosials-Lopez, Giovanna Fico

Faculty, Staff and Student Publications

Objective: Despite the availability of approved treatments, a substantial proportion of patients with bipolar disorder experience treatment-resistant bipolar depression (TRBD), characterized by persistent depressive symptoms unresponsive to standard therapies. However, a universally accepted definition of TRBD is lacking. This consensus document, developed by the International Society for Bipolar Disorders (ISBD) Task Force on TRBD, aims to provide a standardized definition of TRBD to facilitate clinical trials, research, and treatment strategies.

Methods: The Task Force employed a literature review, clinical trials analysis, and expert consensus meetings to define TRBD.

Results: TRBD was defined as the failure to achieve a significant and …

An Exciting Future For Microbial Molecular Biology And Physiology, Andrew A Bridges, Leah Guthrie, Mckenzie Lehman, Elizabeth H Kellogg, Samantha Wellington Miranda, Andrew Pountain, Anthony L Shiver, Andrew Varble, Molecular Biology And Physiology Community Of The Council On Microbial Sciences, Heidi B Kaplan, Elizabeth A Shank, Gisela Storz

Faculty, Staff and Student Publications

Continuous advances in technologies ranging from deep sequencing and genetic manipulation to mass spectrometry, single cell imaging, and structural biology have led to previously unimaginable advances in our understanding of microbial physiology and the molecular mechanisms underlying microbial responses in a multitude of environments. Simultaneously, these advances are revealing how much more there is to learn. At the 2024 virtual retreat of the Molecular Biology and Physiology (MBP) Community of the Council on Microbial Sciences (COMS) of the American Society for Microbiology (ASM), eight early-career investigators, along with retreat attendees, discussed some of these astounding advances, as well as the …

Structural Insights Into Ssna1 Self-Assembly And Its Microtubule Binding For Centriole Maintenance, Lorenzo Agostini, Jason A Pfister, Nirakar Basnet, Jienyu Ding, Rui Zhang, Christian Biertümpfel, Kevin F O'Connell, Naoko Mizuno

2020-Current year OA Pubs

SSNA1 is a fibrillar protein involved in dynamic microtubule remodeling, including nucleation, co-polymerization, and microtubule branching. The underlying molecular mechanism has remained unclear due to a lack of structural information. Here, we determine the cryo-EM structure of C.elegans SSNA-1 at 4.55-Å resolution and evaluate its role in embryonic development. We find that SSNA-1 forms an anti-parallel coiled-coil, with self-assembly facilitated by an overhang of 16 C-terminal residues that form a triple-stranded helical junction. The microtubule-binding region is within the triple-stranded junction, suggesting that self-assembly of SSNA-1 creates hubs for effective microtubule interaction. Genetical analysis elucidates that SSNA-1 deletion significantly reduces …

Established And Emerging Asthma Biomarkers With A Focus On Biologic Trials: A Narrative Review, Philip F Lavere, Kaitlin M Phillips, Nicola A Hanania, Muhammad Adrish

Faculty, Staff and Students Publications

Chronic airway inflammation with variable airflow obstruction is clinical asthma, and it arises from distinct molecular and pathological mechanisms called endotypes. Biomarkers allow for precise endotype characterization and have been used in clinical trials to design, monitor, and evaluate outcomes for asthma biologic therapies. This review will highlight the central and evolving role of biomarkers for past, present, and future asthma, with a focus on regulatory-approved biologic therapies and emerging biomarkers. Established biomarkers, including serum immunoglobulin E (IgE), blood eosinophils, the fraction of exhaled nitric oxide (FeNO), and serum periostin, helped elucidate the complex pathophysiology of the eosinophilic type 2 …

Butte Priority Soils Operable Unit (Bpsou) Draft Final Reclamation Improvement Sites Field Sampling And Investigation Plan (Fsp): Bres No. 18 – Walkerville Ballfield, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Climate - Commercial And Scientific Instrument Opportunities For Small Satellite Constellations, Alex Da Silva Curiel, Rob Elliott, Tony Canas, Stephanie Mottershead, Andy Palfreyman, Martin Sweeting Sir

Small Satellite Conference

There is an economic and social impact in many areas in the world due to lack of information on local climate, and better understanding is widely believed to lead to cost savings and improved living standards. Despite the wealth of spacecraft data available today, many climate variables are still poorly monitored. Small satellites in constellation can help in filling data gaps, and also provides the important temporal resolution required. Such missions could be highly complementary to the NASA NEO and EU Copernicus programs, and their data can be commercially valuable, opening up the potential for novel business models and services. …

Review Of Microgravity Biotechnology For Space Applications: The Anujiva Perspective, Saranya Ravva, Yukti Makkar, Abeneth Ramachandran, Sai Kiran Parre

Small Satellite Conference

Biomanufacturing in microgravity presents transformative opportunities for biotechnology beyond the limitations of terrestrial environments. Gravity-driven convection, sedimentation, and contamination risks often hinder biological productivity on Earth. In contrast, space-based conditions enhance protein crystallization, three-dimensional cell culture, and the production of novel biomaterials. This review synthesizes recent advancements in microgravity-enabled biotechnology, drawing from recent peer-reviewed literature and mission data.

We focus on the emerging field of autonomous bioreactor systems for space applications, emphasizing innovations in miniaturization, closed-loop environmental control, and real-time sensing. As a representative case study, we examine the AnuJIVA initiative, a CubeSat-based platform engineered for cultivating microorganisms such as …

Book Review On Epistemology Of Modality And Philosophical Methodology (Edited By Anand Jayprakash Vaidya And Duško Prelević), Kumar Rajan

Comparative Philosophy

No abstract provided.

Moral And Ethical Nature In Confucian Liang-Zhi And Islamic Fitra: Comparative Perspectives On Innate Morality, Yanrong Shi

Comparative Philosophy

This article offers a comparative philosophical analysis of Confucian liang-zhi (innate moral knowledge) and Islamic fitra(primordial nature), focusing on their accounts of innate morality and moral epistemology. Drawing on classical Confucian sources—especially the praxis-oriented interpretation of Wang Yangming—and foundational Islamic texts and commentary, the study demonstrates that both traditions posit an inborn moral faculty grounding ethical universality and responsibility. Wang Yangming’s liang-zhi is conceived as an innate moral principle that, under the imperative of zhi (to actualize or extend), is continually activated through moral practice. In parallel, fitra is understood as a God-given orientation to truth, cultivated and safeguarded through …

The Conventional Emptiness Of Human Beings: Reviewing Archer’S Theory Of Agency Through Nagarjuna’S Looking Glass, Federico Podestà

Comparative Philosophy

Margaret Archer is probably the critical realist who has most significantly affected the debate around the relationship between social structure and agency. In the volume, Being Human: The Problem of Agency, she aims to better define what is meant by the properties and causal powers of agency itself, i.e., self-consciousness and reflexivity. In this paper, this theoretical attempt is reviewed through the critical standpoint of Nagarjuna. Nagarjuna’s philosophy appears to be a particularly compelling tool for criticizing Archer’s theory. Claiming the emptiness of everything, the founder of the Buddhist Madhyamaka school provides a critical perspective for revising the distinctiveness of …

How Theravāda Buddhism Enriches The Language Of Thought Hypothesis: Beyond Syntax, Juanjuan Cheng, Sumanasara Sandamadulle

Comparative Philosophy

The Language of Thought Hypothesis (LOTH) posits that mental states operate through a language-like representational system physically implemented in the brain. However, this purely symbolic approach faces a significant limitation: certain mental phenomena—such as intuitions, emotions, and intentions—lack the syntactically compositional structure required by LOTH and therefore cannot be adequately explained within its symbolic framework. To address this theoretical challenge, we turn to Theravāda Buddhism (TB), an early Buddhist tradition that integrates rigorous philosophical inquiry with meditative practice. Remarkably, TB began to prefigure a solution to LOTH’s limitations over 2,300 years ago. Although LOTH and TB differ …

Extended Testing Of A Steam-Powered Propulsion System For Rapid-Orbit Corrections: A Viable Alternative To Chemical Propulsion, Marco Pavan, Ivan Timofeev, Vladimir Fedorov, Jinyoung Shin

Small Satellite Conference

The Steam Thruster One is an electro-thermal propulsion system capable of delivering a thrust level up to 20 mN, using 20 W of power and reaching a total impulse of about 1200 Ns in its 2U configuration. The system operates solely on low-pressure water, ensuring complete safety for integration and operations both on the ground and in space. The propulsion cycle involves converting liquid water into superheated steam, which is then expanded through a nozzle to generate thrust.

The propulsion system was tested in space in Q3 2023 and Q2 2024, where it successfully demonstrated short propulsion manoeuvres. However, for …

Stp-H12-Vantage: Combining Visual And Event-Based Sensing For Earth Observation, Diego Wildenstein, Michael J. Cannizzaro, Ian Peitzsch, Linus Silbernagel, Joshua Poravanthattil, Peter Drum, Mark Hofmeister, Cole Bowman, Natan Herzog, Evan W. Gretok, Alan D. George

Small Satellite Conference

Conducting Earth-observation tasks from orbit can provide valuable research insights in fields such as meteorology, geology, forestry, cartography, and defense. Developing and building space payloads for Earth observation poses significant challenges, including the high cost of radiation-tolerant systems, the widening gap between current state-of-the-art apps and the capabilities of space-grade processors, and the increase in fidelity of modern sensors. Many Earth-observation missions typically collect data by leveraging visual and/or multispectral imagers. However, when using conventional imaging, there can be significant losses in context due to the frame-based operation of these sensors, as well as both relevant and irrelevant data mixed …

An Exploratory Study Of Soft Skills Development Expectations In Two-Year Generation Z College Students, Kelli Hallsten Erickson

The Interactive Journal of Global Leadership and Learning

Workplace demands around competent demonstration of soft skills have been steadily increasing; therefore, institutions of higher education have started focusing attention on instilling these skills within their student populations. The latest generational cohort to enter college and the workforce, Generation Z, has only recently begun to be studied for the impact of its members’ attitudes towards work and how those might change employer expectations around soft skills. A research gap exists, however, regarding students in Generation Z attending two-year schools and which soft skills they feel are most valuable to their future careers. This study sought to explore those attitudes …

Development Of Emerin Mrna Lipid Nanoparticles To Rescue Myogenic Differentiation., Nicholas Marano, Liza Elif Guner, Rachel S Riley, James M Holaska

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Emery-Dreifuss muscular dystrophy 1 (EDMD1) arises from mutations in EMD. Most EDMD1 patients lack detectable emerin expression. They experience symptoms such as skeletal muscle wasting, joint contractures, and cardiac conduction defects. Currently, physicians rely on treating patient symptoms without addressing the underlying cause-lack of functional emerin protein. Thus, there is a need for therapeutic approaches that restore emerin protein expression to improve patient outcomes. One way would be to deliver emerin mRNA or protein directly to affected tissues to restore tissue homeostasis. Here, we evaluated the utility of lipid nanoparticles (LNPs) to deliver emerin mRNA to diseased cells. LNPs …

Effect Of Whole-Food Plant-Based Diet On Ldl Cholesterol: A Scoping Literature Review, Joel Gregory Mueller

Nursing Capstones

Background: The whole-food, plant-based (WFPB) diet includes whole grains, whole plants, unrefined sugars, beans, and legumes. The diet excludes meat, dairy, and added fats. The diet has been popularized by documentaries .The diet claims to lower total and LDL cholesterol to a safe level as both a primary and secondary mode of prevention.

Purpose: Review existing studies to see whether the WFPB diet will lower LDL cholesterol in adult males over a 14 day or more duration.

Methods: A scoping literature review was completed of the University of North Dakota’s library system for keyword combinations. The returned 102 studies were …

Assessing The Impact Of Structural And Interpersonal Gendered Racism On Sexual And Reproductive Healthcare Among U.S. Women Of Color, Kimberly Muellers

ETD Collection

No abstract provided.

Variability In Long Covid Definitions And Validation Of Published Prevalence Rates, Lauren E. Wisk, Michelle L'Hommedieu, Kate Diaz Roldan, Imtiaz Ebna Mannan, Erica S. Spatz, Robert A. Weinstein, Arjun K. Venkatesh, Michael Gottlieb, Ryan Huebinger, Kristin L. Rising, Juan Carlos C. Montoy, Kari A. Stephens, Robert M. Rodriguez, Mandy J. Hill, Kelli N. O'Laughlin, Nicole L. Gentile, Ahamed H. Idris, Shu-Xia Li, Michelle Santangelo, Efrat R. Kean, Samuel A. Mcdonald, Kristyn Gatling, Joann G Elmore

Jefferson Center for Connected Care Faculty Papers

IMPORTANCE: Long COVID definitions vary widely, and no consensus exists on how to accurately measure its prevalence, complicating both clinical care and research.

OBJECTIVE: To assess long COVID prevalence using various definitions from published literature.

DESIGN, SETTING, AND PARTICIPANTS: This prospective, multicenter cohort study used data from the longitudinal Innovative Support for Patients With SARS-CoV-2 Infections Registry (INSPIRE). Participants aged 18 years or older with symptoms suggestive of COVID-19 illness at the time of their index SARS-CoV-2 test enrolled at 8 sites across the US from December 11, 2020, through August 29, 2022, with follow-up surveys collected through February 28, …

Autism Awareness Training For Law Enforcement Officers: A Pilot Study, Kaylie Holke, Meghan Cosier, Elissa Green Kaustinen, Cathy Scherer, Andrew Wall

Education Faculty Articles and Research

Purpose

The purpose of this study was to pilot a research-based autism training session for law enforcement officers (LEOs), test the Police Self-Efficacy for Autism (PSEA) scale as a measurement tool for the session and provide a preliminary examination of brief training. Design/methodology/approach

This study utilized a pre-post survey approach in which participants completed the PSEA scale pre- and post-training to measure the relationship between the training and self-efficacy scores. Findings

Results show a positive relationship between brief autism-specific training and officers’ self-efficacy scores across items and subscales. All four subscales and seven of thirteen items demonstrated statistical significance. Originality/value …

Comparative Analysis Of Risk Factors Associated With Guinea Worm Disease In Five Endemic Countries, Junerlyn Virrey Agua

Walden Dissertations and Doctoral Studies

Guinea worm disease (GWD) has persisted in a small number of endemic countries despite decades of eradication efforts. Ongoing GWD transmission in these countries underscores the need to examine behavioral, environmental, and surveillance-related drivers. The purpose of this quantitative study was to assess associations among risk factors, including dog tethering, pond treatment with Abate, and community awareness, and GWD incidence. The study also examined the relationship between climate-related environmental factors and GWD case distribution, as well as the influence of awareness levels on GWD rumor reports. Guided by the PRECEDE–PROCEED framework, this retrospective secondary analysis used data from national eradication …

Six New Members Join Iwu Board Of Trustees, Julia Perez

Press Releases 2020-2029

No abstract provided.

Remote Running Gait Analysis Using Smartphone Video And Monocular Pose Estimation: A Feasibility Study, Luke Vankeersbilck

Theses and Dissertations

Introduction: Running is a common form of exercise that comes with many health benefits; however, many people stop exercising because of the high injury risk. Running injury is connected with biomechanical risk factors. Yet, these risk factors often show inconsistent and conflicting results across studies, largely due to small sample sizes limiting statistical power. Low subject numbers may be partly due to the time requirements of traditional motion capture. Monocular pose estimation offers a promising alternative by using machine learning to track body landmarks from a single camera. This study evaluated the feasibility of remotely collecting running biomechanics data using …

Computational And Mathematical Modeling Of Microbial Community And Host Responses To Microbiota-Directed Complementary Foods Administered To Children With Acute Malnutrition., Steven J. Hartman

Arts & Sciences Graduate Student Theses and Dissertations

Globally, millions of children suffer from undernutrition, with stunting affecting 150 million and wasting nearly 50 million under five years old. Current interventions have shown limited effectiveness in mitigating long-term consequences such as stunted growth, cognitive deficits, and immune dysfunction. Through this body of work, I investigated the efficacy of a microbiota- directed complementary food (MDCF-2) as a next generation therapeutic food to combat childhood stunting. Across two randomized controlled trials involving Bangladeshi children with either moderate acute malnutrition or post-severe acute malnutrition, MDCF-2 significantly outperformed standard ready-to-use supplementary foods (RUSF), leading to significantly improved ponderal and sustained linear growth …

Computational Investigation Of The Structural And Electronic Effects Of Phenyl, Alkyl, And Halogen Fully Substituted Acenes, Emily A A Jarvis, Viraj Jain, Georgia Grace Tully, Peter W. Jarvis

Chemistry and Biochemistry Faculty Works

Acenes are a class of polycyclic aromatic hydrocarbons that may hold promise as organic semiconductors (OSCs) in solar cells and electronic devices. Their instability and poor solubility present challenges that may be improved by replacing the hydrogens with phenyl, halogen or alkyl substituents to sterically induce a helical twist to these otherwise planar molecules. This twisted structure also impacts the optical properties of these molecules. We employ time-dependent density functional theory (TD DFT) to investigate acenes spanning from naphthalene to heptacene. We focus on the structural and electronic effects of fully substituting these molecular backbones to create seven distinct substituent …

The Swib Domain-Containing Dna Topoisomerase I Of Chlamydia Trachomatis Mediates Dna Relaxation, Li Shen, Abigail R. Swoboda, Caitlynn Diggs, Shomita Ferdous, Andrew Terrebonne, Amanda Santos, Noel Wolf, Luis Lorenzo Carvajal, Guangming Zhong, Scot P. Ouellette, Yuk Ching Tse-Dinh

School of Graduate Studies Faculty Publications

Chlamydia trachomatis has a DNA topoisomerase I with a unique C-terminal domain (CTD) homologous to eukaryotic SWIB domains. This study focused on determining the function of the SWIB domain-containing TopA from C. trachomatis (CtTopA). We demonstrated that, despite the lack of sequence similarity at the CTDs between CtTopA and TopA from Escherichia coli (EcTopA), full-length CtTopA removed negative DNA supercoils in vitro and complemented the growth defect of a topA mutant of E. coli. CtTopA is less processive in DNA relaxation than EcTopA in dose-response and time course studies. An antibody generated against the SWIB domain of CtTopA specifically recognized …

Non-Isolated Tetralogy Of Fallot (Tof+): Exome Sequencing Efficacy And Phenotypic Expansions, Julia Volpi, Xiaonan Zhao, Nichole Owen, Tia Evans, Muriel Holder-Espinasse, Nayana Lahiri, Eleanor Sherlock, Gemma Poke, Jeroen Breckpot, Koen Devriendt, Bjorn Cools, Alfredo Brusco, Giovanni Battista Ferrero, Enrico Grosso, Pradeep Vasudevan, Sara Loddo, Antonio Novelli, Maria Cristina Digilio, Aafke Engwerda, Marrit Hitzert, Alison Male, Lucy Bownass, Ruth Newbury-Ecob, Zosia Miedzybrodzka, Ruth Armstrong, Sally Ann Lynch, Gunnar Houge, Shiyi Xiong, Seema R Lalani, Jill A Rosenfeld, Pamela N Luna, Chad A Shaw, Daryl A Scott

Faculty, Staff and Students Publications

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect (CHD). TOF may present in isolation or in conjunction with one or more non-cardiac congenital anomalies or neurodevelopmental disorders (TOF+). Uncertainty regarding the efficacy of various genetic testing strategies, and an incomplete understanding of the genetic causes of TOF+, may lead to hesitancy in recommending genetic testing, particularly, clinical exome sequencing (cES). Here, we analyzed cES data from 131 individuals with TOF+. A definitive or probable diagnosis was made for 31 individuals, yielding a diagnostic rate of 23.6% (31/131). One individual received three diagnoses. Commercially available CHD panels …

Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites Field Sampling And Investigation Plan (Fsp): Bres No. 100 – Capri Motel – Arctic Dump, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Work Extracting And Second Law-Like Inequalities From Non-Extensive Small Systems With Feedback, Mehdi Mirzaee, Saman Amiri

Turkish Journal of Physics

The Gibbs-Boltzmann entropy effectively characterizes systems with a significant reliance on initial conditions. Nonetheless, the majority of materials generally exhibit behavior that is independent of their initial conditions. Conversely, Tsallis entropy—a nonextensive entropy that underpins nonextensive statistical mechanics—provides a comprehensive framework for modeling systems that engage with their environment. In this study, we derive the Tsallis formulation of the Clausius inequality in a quantum context and establish an upper limit for the work that can be extracted from a small system within the framework of nonextensive quantum statistical mechanics. Furthermore, by utilizing a principle from quantum information theory—which posits that …

Foster Kinship Program Evaluation, Eduardo Cabral-Terrazas, Jamilah Mcgrue, Andrea Rangelova, Jeffrey Vanderlaan

Public Policy and Leadership Theses & Dissertations

Foster Kinship, a Nevada-based nonprofit, operates under the belief that “When children cannot be with their parents, they should be with their family” (Foster Kinship, 2022). It supports kinship caregivers, who often take in children during a crisis, in navigating the foster care system. The organization’s Kinship Navigator Program offers training, case management, and licensing support to kinship caregivers, enabling them to access financial assistance and other benefits. However, many caregivers who complete the training do not finish the licensing process, limiting placement stability and access to resources for the children. Understanding why kinship caregivers trained through the Foster Kinship …

Under The Sea And Into The Future With Darwin, Verne, & Wells: Evolutionary Ideas In Early Science Fiction Literature And Atomic Age Adaptations, Suzette K. Forston

Theses and Dissertations

In the latter half of the nineteenth century, Charles Darwin's theories challenged traditional ways of thinking about the world so dramatically that his writings inspired the formation of a new genre: science fiction. Two pioneering authors, Jules Verne and H. G. Wells drew from Darwin's writings in their classic novels, 20,000 Leagues Under the Seas (1870) and The Time Machine (1895). Though the two authors are often compared because they were both early science fiction authors, they approached Darwinian theory in different ways. Verne uses a more extrapolative approach and focusing on specific details of Darwin's texts to tell a …