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2023

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Mimosa 2022/2023, Jacksonville State University Jan 2023

Mimosa 2022/2023, Jacksonville State University

JSU Yearbooks

The JSU Yearbook Collection spans the years from 1926 to the present. The publication began in 1926 as the Teacola (some volumes spelled "Teacoala") and continued under this title through 1933. The yearbook appears to have ceased printing after that year; the student newspaper took the name Teacola (later changed to the Collegian and finally the Chanticleer) and began publication in 1934. The yearbook started up again in 1947 under the name Mimosa. The Library holds all volume years that were printed: 1926-1933, 1947-1950, 1952-present.

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Framework For Classifying Explainable Artificial Intelligence (Xai) Algorithms In Clinical Medicine, Thomas Gniadek, Jason Kang, Talent Theparee, Jacob Krive Jan 2023

Framework For Classifying Explainable Artificial Intelligence (Xai) Algorithms In Clinical Medicine, Thomas Gniadek, Jason Kang, Talent Theparee, Jacob Krive

HPD Articles

Artificial intelligence (AI) applied to medicine offers immense promise, in addition to safety and regulatory concerns. Traditional AI produces a core algorithm result, typically without a measure of statistical confidence or an explanation of its biological-theoretical basis. Efforts are underway to develop explainable AI (XAI) algorithms that not only produce a result but also an explanation to support that result. Here we present a framework for classifying XAI algorithms applied to clinical medicine: An algorithm’s clinical scope is defined by whether the core algorithm output leads to observations (eg, tests, imaging, clinical evaluation), interventions (eg, procedures, medications), diagnoses, and prognostication. …

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Which Blazer Kitchen Volunteer Are You? Find Your Perfect Fit For 2023, Matt Windsor Jan 2023

Which Blazer Kitchen Volunteer Are You? Find Your Perfect Fit For 2023, Matt Windsor

Browse All News

No abstract provided.

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Flood Risk Assessment For Residences At The Neighborhood Scale By Owner/Occupant Type And First-Floor Height, Ayat Al Assi, Rubayet Bin Mostafiz, Carol J. Friedland, Md Adilur Rahim, Robert V. Rohli Jan 2023

Flood Risk Assessment For Residences At The Neighborhood Scale By Owner/Occupant Type And First-Floor Height, Ayat Al Assi, Rubayet Bin Mostafiz, Carol J. Friedland, Md Adilur Rahim, Robert V. Rohli

Faculty Publications

Evaluating flood risk is an essential component of understanding and increasing community resilience. A robust approach for quantifying flood risk in terms of average annual loss (AAL) in dollars across multiple homes is needed to provide valuable information for stakeholder decision-making. This research develops a computational framework to evaluate AAL at the neighborhood level by owner/occupant type (i.e., homeowner, landlord, and tenant) for increasing first-floor height (FFH). The AAL values were calculated here by numerically integrating loss-exceedance probability distributions to represent economic annual flood risk to the building, contents, and use. A simple case study for a census block in …

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Ethno-Conservation Of New Guinea Singing Dog Among Tribes In Pegunungan Tengah, Papua, Indonesia, Arni Syawal, Satyawan Pudyatmoko, Lies Rahayu Wijayanti Faida, Elieser Viktor Sirami, Esti Gesang Setyadi, Pratita Puradyatmika, Rendy Enggar Suwandi, Muhammad Ali Imron Jan 2023

Ethno-Conservation Of New Guinea Singing Dog Among Tribes In Pegunungan Tengah, Papua, Indonesia, Arni Syawal, Satyawan Pudyatmoko, Lies Rahayu Wijayanti Faida, Elieser Viktor Sirami, Esti Gesang Setyadi, Pratita Puradyatmika, Rendy Enggar Suwandi, Muhammad Ali Imron

Forest and Society

Interactions between humans and carnivores have been range from positive to negative, occasionally leading to human-wildlife conflict in many parts of the world. While dogs have roles to support humans, wild dogs such as wolf, dingoes, and singing dogs have both potential positive and negative roles for humans. We gathered knowledge among tribes in Pegunungan Tengah of Papua, Indonesia on their interactions with the New Guinea Singing Dog (NGSD) using an ethno-conservation approach. We conducted in-depth interviews using both emit and etic approaches with informants from the Amungme, Damal, Moni and Dani (Lani) tribes, who live in the habitat of …

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Impact And Mitigation Measures Of Covid-19 Towards Food Security Through Participation In Forest Management By Community In Sook, Keningau District, Sabah, Vilaretti Atin, Walter Lintangah Jan 2023

Impact And Mitigation Measures Of Covid-19 Towards Food Security Through Participation In Forest Management By Community In Sook, Keningau District, Sabah, Vilaretti Atin, Walter Lintangah

Forest and Society

The COVID-19 pandemic has significantly impacted food security for the people due to the imposition of stringent measures to halt the spread of COVID-19 transmission. This study aimed to measure the community's perception of the level of COVID-19 impacts on their food security and to identify the community's participation in forest management around the Forest Management Unit (FMU) in Sook, Keningau District of Sabah, to improve their livelihood. A mixed-method approach was conducted where a total of 122 respondents were sampled using a questionnaire survey, focus group discussion with communities, and expert interviews to gather more valuable data. The result …

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Estimation And Mapping Above-Ground Mangrove Carbon Stock Using Sentinel-2 Data Derived Vegetation Indices In Benoa Bay Of Bali Province, Indonesia, A. A. Md. Ananda Putra Suardana, Nanin Anggraini, Muhammad Rizki Nandika, Kholifatul Aziz, Abd. Rahman As-Syakur, Azura Ulfa, Agung Dwi Wijaya, Wiji Prasetio, Gathot Winarso, Ratih Dewanti Jan 2023

Estimation And Mapping Above-Ground Mangrove Carbon Stock Using Sentinel-2 Data Derived Vegetation Indices In Benoa Bay Of Bali Province, Indonesia, A. A. Md. Ananda Putra Suardana, Nanin Anggraini, Muhammad Rizki Nandika, Kholifatul Aziz, Abd. Rahman As-Syakur, Azura Ulfa, Agung Dwi Wijaya, Wiji Prasetio, Gathot Winarso, Ratih Dewanti

Forest and Society

Carbon dioxide (CO2) is one of the greenhouse gases that causes global warming with the highest concentration in the atmosphere. Mangrove forests can absorb CO2 three times higher than terrestrial forests and tropical rainforests. Moreover, mangrove forests can be a source of Indonesian income in the form of a blue economy, therefore an accurate method is needed to investigates mangrove carbon stock. Utilization of remote sensing data with the results of the above-ground carbon (AGC) detection model of mangrove forests based on multispectral imaging and vegetation index, can be a solution to get fast, cheap, and accurate …

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Peatland Fire Regime Across Riau Peat Hydrological Unit, Indonesia, Annuri Rossita, Rizaldi Boer, Lars Hein, Dodik Nurrochmat, Akhmad Riqqi Jan 2023

Peatland Fire Regime Across Riau Peat Hydrological Unit, Indonesia, Annuri Rossita, Rizaldi Boer, Lars Hein, Dodik Nurrochmat, Akhmad Riqqi

Forest and Society

Peatland stretches across approximately 8% of Indonesia's land area. Peat fire disturbance, which affects the carbon dynamics of the ecosystem, will determine the country's vision for a long-term strategy for low carbon development. While the impact of excessive draining on peatland fire is well-known to the scientific community, much less is known about peatland fire regimes in distinctive land management systems. We examined the effect of land use, land management, and climatic factors in peatland fires. The examination was performed at the Peat Hydrological Unit at Gaung?Batang Tuaka, Riau, Indonesia. We used a semi-automatic approach to determine the area of …

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Disabling Uncompetitive Inhibition Of Oncogenic Idh Mutations Drives Acquired Resistance, Junhua Lyu, Yuxuan Liu, Lihu Gong, Mingyi Chen, Yazan F Madanat, Yuannyu Zhang, Feng Cai, Zhimin Gu, Hui Cao, Pranita Kaphle, Yoon Jung Kim, Fatma N Kalkan, Helen Stephens, Kathryn E Dickerson, Min Ni, Weina Chen, Prapti Patel, Alice S Mims, Uma Borate, Amy Burd, Sheng F Cai, C Cameron Yin, M James You, Stephen S Chung, Robert H Collins, Ralph J Deberardinis, Xin Liu, Jian Xu Jan 2023

Disabling Uncompetitive Inhibition Of Oncogenic Idh Mutations Drives Acquired Resistance, Junhua Lyu, Yuxuan Liu, Lihu Gong, Mingyi Chen, Yazan F Madanat, Yuannyu Zhang, Feng Cai, Zhimin Gu, Hui Cao, Pranita Kaphle, Yoon Jung Kim, Fatma N Kalkan, Helen Stephens, Kathryn E Dickerson, Min Ni, Weina Chen, Prapti Patel, Alice S Mims, Uma Borate, Amy Burd, Sheng F Cai, C Cameron Yin, M James You, Stephen S Chung, Robert H Collins, Ralph J Deberardinis, Xin Liu, Jian Xu

Faculty, Staff and Student Publications

Mutations in IDH genes occur frequently in acute myeloid leukemia (AML) and other human cancers to generate the oncometabolite R-2HG. Allosteric inhibition of mutant IDH suppresses R-2HG production in a subset of patients with AML; however, acquired resistance emerges as a new challenge, and the underlying mechanisms remain incompletely understood. Here we establish isogenic leukemia cells containing common IDH oncogenic mutations by CRISPR base editing. By mutational scanning of IDH single amino acid variants in base-edited cells, we describe a repertoire of IDH second-site mutations responsible for therapy resistance through disabling uncompetitive enzyme inhibition. Recurrent mutations at NADPH …

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A Molecular Switch Between Mammalian Mll Complexes Dictates Response To Menin-Mll Inhibition, Yadira M Soto-Feliciano, Francisco J Sánchez-Rivera, Florian Perner, Douglas W Barrows, Edward R Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Disha Anand, Alexey A Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X Shirley Liu, Andrei V Krivtsov, Maximiliano Meneses, Elisa De Stanchina, Richard M Stone, Scott A Armstrong, Scott W Lowe, C David Allis Jan 2023

A Molecular Switch Between Mammalian Mll Complexes Dictates Response To Menin-Mll Inhibition, Yadira M Soto-Feliciano, Francisco J Sánchez-Rivera, Florian Perner, Douglas W Barrows, Edward R Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Disha Anand, Alexey A Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X Shirley Liu, Andrei V Krivtsov, Maximiliano Meneses, Elisa De Stanchina, Richard M Stone, Scott A Armstrong, Scott W Lowe, C David Allis

Faculty, Staff and Student Publications

Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these associations are in clinical trials for leukemia treatment. By integrating chromatin-focused and genome-wide CRISPR screens with genetic, pharmacologic, and biochemical approaches, we discovered a conserved molecular switch between the MLL1-Menin and MLL3/4-UTX chromatin-modifying complexes that dictates response to Menin-MLL inhibitors. MLL1-Menin safeguards leukemia survival by impeding the binding of the MLL3/4-UTX complex at a subset of target gene promoters. Disrupting the Menin-MLL1 interaction triggers UTX-dependent transcriptional activation of a tumor-suppressive program that dictates therapeutic responses in murine and human leukemia. Therapeutic reactivation of this program using CDK4/6 inhibitors …

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Identification Of Collaborative Cross Mouse Strains Permissive To Salmonella Enterica Serovar Typhi Infection, Kishore Alugupalli, Sudeep Kothari, Matthew P Cravens, Justin A Walker, Darren T Dougharty, Gregory S. Dickinson, Louis A Gatto, Andreas J Bäumler, Tamding Wangdi, Darla R Miller, Fernando Pardo-Manuel De Villena, Linda D Siracusa Jan 2023

Identification Of Collaborative Cross Mouse Strains Permissive To Salmonella Enterica Serovar Typhi Infection, Kishore Alugupalli, Sudeep Kothari, Matthew P Cravens, Justin A Walker, Darren T Dougharty, Gregory S. Dickinson, Louis A Gatto, Andreas J Bäumler, Tamding Wangdi, Darla R Miller, Fernando Pardo-Manuel De Villena, Linda D Siracusa

Department of Microbiology and Immunology Faculty Papers

Salmonella enterica serovar Typhi is the causative agent of typhoid fever restricted to humans and does not replicate in commonly used inbred mice. Genetic variation in humans is far greater and more complex than that in a single inbred strain of mice. The Collaborative Cross (CC) is a large panel of recombinant inbred strains which has a wider range of genetic diversity than laboratory inbred mouse strains. We found that the CC003/Unc and CC053/Unc strains are permissive to intraperitoneal but not oral route of S. Typhi infection and show histopathological changes characteristic of human typhoid. These CC strains are immunocompetent, …

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Soil Water Sensors For Irrigation Scheduling In The United States: A Systematic Review Of Literature, Sumon Datta, Saleh Taghvaeian Jan 2023

Soil Water Sensors For Irrigation Scheduling In The United States: A Systematic Review Of Literature, Sumon Datta, Saleh Taghvaeian

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Soil water sensors (SWS) have been widely researched and practiced for irrigation scheduling. Due to popularity of this approach, there is a need for frequent reviews of the SWS literature to keep the researchers, extension professionals, and end-users updated and to help with defining and modifying future directions. In addition, existing literature reviews do not systematically report and summarize the results of previous studies. To address this gap, a systematic review was carried out to identify and analyze related literature published in the United States in the past two decades. Two focus areas were SWS accuracy assessment and SWS application …

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Evolution And Molecular Basis Of A Novel Allosteric Property Of Crocodilian Hemoglobin, Chandrasekhar Natarajan, Anthony V. Signore, Naim M. Bautista, Federico G. Hoffmann, Jeremy R.H. Tame, Angela Fago, Jay F. Storz Jan 2023

Evolution And Molecular Basis Of A Novel Allosteric Property Of Crocodilian Hemoglobin, Chandrasekhar Natarajan, Anthony V. Signore, Naim M. Bautista, Federico G. Hoffmann, Jeremy R.H. Tame, Angela Fago, Jay F. Storz

School of Biological Sciences: Faculty Publications

The extraordinary breath-hold diving capacity of crocodilians has been ascribed to a unique mode of allosterically regulating hemoglobin (Hb)-oxygenation in circulating red blood cells. We investigated the origin and mechanistic basis of this novel biochemical phenomenon by performing directed mutagenesis experiments on resurrected ancestral Hbs. Comparisons of Hb function between the common ancestor of archosaurs (the group that includes crocodilians and birds) and the last common ancestor of modern crocodilians revealed that regulation of Hb-O2 affinity via allosteric binding of bicarbonate ions represents a croc-specific innovation that evolved in combination with the loss of allosteric regulation by ATP binding. …

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Using Innovative Copper‑Loaded Activated Alumina (Cu/Aa) As The Catalyst For Catalytic Wet Peroxidation (Cwpo) Of Catechol, Vijayalakshmi Gosu, Archana Dhakar, Tian C. Zhang, Rao Y. Surampalli, Verraboina Ubbaramaiah Jan 2023

Using Innovative Copper‑Loaded Activated Alumina (Cu/Aa) As The Catalyst For Catalytic Wet Peroxidation (Cwpo) Of Catechol, Vijayalakshmi Gosu, Archana Dhakar, Tian C. Zhang, Rao Y. Surampalli, Verraboina Ubbaramaiah

Department of Civil and Environmental Engineering: Faculty Publications

In this study, copper-loaded activated alumina (Cu/AA) was synthesized and used for the CWPO of catechol (a representative refractory organic pollutant). Various characterization techniques were deployed to characterize the catalysts, e.g., activated alumina (AA), as well as pristine and spent 1% Cu/AA. The innovative 1% Cu/AA catalyst exhibited good thermal stability up to 1173 K with a marginal weight loss of 13%. The Cu species were well dispersed on the activated alumina framework with no significant cluster formation. Typically, the average copper particle size of 5 nm was dispersed on the AA framework. Catechol removal was observed to be 92% …

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Urban Green Space Analysis And Its Effect On The Surface Urban Heat Island Phenomenon In Denpasar City, Bali, I Kade Alfian Kusuma Wirayuda, Prima Widayani, Andung Bayu Sekaranom Jan 2023

Urban Green Space Analysis And Its Effect On The Surface Urban Heat Island Phenomenon In Denpasar City, Bali, I Kade Alfian Kusuma Wirayuda, Prima Widayani, Andung Bayu Sekaranom

Forest and Society

The Urbanization process in Indonesia’s big cities causes adverse environmental impacts such as climate change and land cover change. Urban climate change causes the warming of urban areas compared to rural areas; it is called Urban Heat Island phenomenon. Loss of vegetation due to urban development is one of several causes that contribute to urban heat islands. This study examines the availability of green spaces and their effects on the surface urban heat island in Denpasar city. This study used the spatial approach for Urban Green space mapping with digitizing methods. Landsat 8's thermal band is used for land surface …

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Will Indigenous Ecological Knowledge Vanish? Assessing Persistence Of The Celako Kemali In Farming Practices Among The Serawainese In Bengkulu, Indonesia, Panji Suminar Jan 2023

Will Indigenous Ecological Knowledge Vanish? Assessing Persistence Of The Celako Kemali In Farming Practices Among The Serawainese In Bengkulu, Indonesia, Panji Suminar

Forest and Society

Indonesia is home to many indigenous peoples who can preserve the environment through their traditions amid the increasing of external values ​​and lifestyles’ penetration. The following presents the indigenous ecological knowledge of the Serawai people in the form of the celako kemali. Based on insights from the Indigenous research methods, this study aims first to assess the persistence of the celako kemali as a method for farming practices. Second, to identify transmission patterns of the celako kemali among generations in the Serawai community. This study found that there were 19 types of celako kemali. The current analysis demonstrates …

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Living Through Crises Due To Successive Commodity Booms And Busts: Investigating The Changing Peasants' Farming Style In Rural Indonesia, Muchlas Dharmawan Tualle, A. Mujetahid, Muhammad Dassir, Nurhady Sirimorok, A. Khalid Muhammad, Andi Vika Faradiba Muin, Aryo Dwi Prasetyo Jan 2023

Living Through Crises Due To Successive Commodity Booms And Busts: Investigating The Changing Peasants' Farming Style In Rural Indonesia, Muchlas Dharmawan Tualle, A. Mujetahid, Muhammad Dassir, Nurhady Sirimorok, A. Khalid Muhammad, Andi Vika Faradiba Muin, Aryo Dwi Prasetyo

Forest and Society

This study aims to explain how a peasant community makes decisions in response to recurring crises in order to maintain their farms, and the extent to which vulnerability contexts and (external) institutions influence peasants’ decision-making regarding their livelihoods. In doing so, we present a case study of the Village of Ranga, in the South Sulawesi Province, Indonesia, where data collected through semi-structured interviews, observation, and Focus Group Discussion (FGD). Data regarding farmers' livelihood strategies in responding to the crises, in the form of commodity booms and busts, is analyzed by employing a sustainable rural livelihoods framework, while a Chayanovian “balance” …

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Religion And Conceptualizing Disability: An Investigation Of Christian Approaches To Disability, Annie Whitley Jan 2023

Religion And Conceptualizing Disability: An Investigation Of Christian Approaches To Disability, Annie Whitley

Student Scholarship

No abstract provided.

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Drugs Targeting P53 Mutations With Fda Approval And In Clinical Trials., Shigeto Nishikawa, Tomoo Iwakuma Jan 2023

Drugs Targeting P53 Mutations With Fda Approval And In Clinical Trials., Shigeto Nishikawa, Tomoo Iwakuma

Manuscripts, Articles, Book Chapters and Other Papers

Mutations in the tumor suppressor p53 (p53) promote cancer progression. This is mainly due to loss of function (LOS) as a tumor suppressor, dominant-negative (DN) activities of missense mutant p53 (mutp53) over wild-type p53 (wtp53), and wtp53-independent oncogenic activities of missense mutp53 by interacting with other tumor suppressors or oncogenes (gain of function: GOF). Since p53 mutations occur in ~50% of human cancers and rarely occur in normal tissues, p53 mutations are cancer-specific and ideal therapeutic targets. Approaches to target p53 mutations include (1) restoration or stabilization of wtp53 conformation from missense mutp53, (2) rescue of p53 nonsense mutations, (3) …

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Poly(Pro-Curcumin) Materials Exhibit Dual Release Rates And Prolonged Antioxidant Activity As Thin Films And Self-Assembled Particles, Ruiwen Chen, Jessica L. Funnell, Geraldine B. Quinones, Marvin Bentley, Jeffrey R. Capadona, Ryan J. Gilbert, Edmund F. Palermo Jan 2023

Poly(Pro-Curcumin) Materials Exhibit Dual Release Rates And Prolonged Antioxidant Activity As Thin Films And Self-Assembled Particles, Ruiwen Chen, Jessica L. Funnell, Geraldine B. Quinones, Marvin Bentley, Jeffrey R. Capadona, Ryan J. Gilbert, Edmund F. Palermo

Chemical and Biochemical Engineering Faculty Research & Creative Works

Curcumin is a natural polyphenol that exhibits remarkable antioxidant and anti-inflammatory activities; however, its clinical application is limited in part by its physiological instability. Here, we report the synthesis of curcumin-derived polyesters that release curcumin upon hydrolytic degradation to improve curcumin stability and solubility in physiological conditions. Curcumin was incorporated in the polymer backbone by a one-pot condensation polymerization in the presence of sebacoyl chloride and polyethylene glycol (PEG, Mn = 1 kDa). The thermal and mechanical properties, surface wettability, self-assembly behavior, and drug-release kinetics all depend sensitively on the mole percentage of curcumin incorporated in these statistical copolymers. Curcumin …

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Subunit Vaccine Targeting Phosphate Abc Transporter Atp-Binding Protein, Pstb, Provides Cross-Protection Against Streptococcus Suis Serotype 2, 7, And 9 In Mice, Zujie Yan, Xiaohui Yao, Ruyi Pan, Junjie Zhang, X Ma, Nihua Dong, Jianchao Wei, K Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A. Jarvis, Mathew Upton, X Li, Z Ma, J Liu, B Li Jan 2023

Subunit Vaccine Targeting Phosphate Abc Transporter Atp-Binding Protein, Pstb, Provides Cross-Protection Against Streptococcus Suis Serotype 2, 7, And 9 In Mice, Zujie Yan, Xiaohui Yao, Ruyi Pan, Junjie Zhang, X Ma, Nihua Dong, Jianchao Wei, K Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A. Jarvis, Mathew Upton, X Li, Z Ma, J Liu, B Li

School of Biomedical Sciences

Streptococcus suis is a significant pathogen in pigs and a newly emerging zoonotic agent in humans. The presence of multiple serotypes and strains with diversified sequence types in pig herds highlights the need for the identification of broadly cross-reactive universal vaccine antigen targets, capable of providing cross-protection against S. suis infection. Subunit vaccines based on the conserved proteins shared between different S. suis serotypes are potential candidates for such a universally protective vaccine. In the present study, phosphate ABC transporter ATP-binding protein PstB (PstB), an immunogenic protein of the S. suis bacterium, was expressed and purified, and then subjected to …

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Subunit Vaccine Targeting Phosphate Abc Transporter Atp-Binding Protein, Pstb, Provides Cross-Protection Against Streptococcus Suis Serotype 2, 7, And 9 In Mice, Zujie Yan, Xiaohui Yao, Ruyi Pan, Junjie Zhang, X Ma, Nihua Dong, Jianchao Wei, K Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A. Jarvis, Mathew Upton, Xiangdong Li, Z Ma, J Liu, B Li Jan 2023

Subunit Vaccine Targeting Phosphate Abc Transporter Atp-Binding Protein, Pstb, Provides Cross-Protection Against Streptococcus Suis Serotype 2, 7, And 9 In Mice, Zujie Yan, Xiaohui Yao, Ruyi Pan, Junjie Zhang, X Ma, Nihua Dong, Jianchao Wei, K Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A. Jarvis, Mathew Upton, Xiangdong Li, Z Ma, J Liu, B Li

School of Biomedical Sciences

Streptococcus suis is a significant pathogen in pigs and a newly emerging zoonotic agent in humans. The presence of multiple serotypes and strains with diversified sequence types in pig herds highlights the need for the identification of broadly cross-reactive universal vaccine antigen targets, capable of providing cross-protection against S. suis infection. Subunit vaccines based on the conserved proteins shared between different S. suis serotypes are potential candidates for such a universally protective vaccine. In the present study, phosphate ABC transporter ATP-binding protein PstB (PstB), an immunogenic protein of the S. suis bacterium, was expressed and purified, and then subjected to …

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Not A Waste: Wastewater Surveillance To Enhance Public Health, Anna Gitter, Jeremiah Oghuan, Anuja Rajendra Godbole, Carlos A. Chavarria, Carlos Monserrat, Tao Hu, Yun Wang, Anthony W. Maresso, Blake M. Hanson, Kristina D. Mena, Fuqing Wu Jan 2023

Not A Waste: Wastewater Surveillance To Enhance Public Health, Anna Gitter, Jeremiah Oghuan, Anuja Rajendra Godbole, Carlos A. Chavarria, Carlos Monserrat, Tao Hu, Yun Wang, Anthony W. Maresso, Blake M. Hanson, Kristina D. Mena, Fuqing Wu

Pharmacy Faculty Articles and Research

Domestic wastewater, when collected and evaluated appropriately, can provide valuable health-related information for a community. As a relatively unbiased and non-invasive approach, wastewater surveillance may complement current practices towards mitigating risks and protecting population health. Spurred by the COVID-19 pandemic, wastewater programs are now widely implemented to monitor viral infection trends in sewersheds and inform public health decision-making. This review summarizes recent developments in wastewater-based epidemiology for detecting and monitoring communicable infectious diseases, dissemination of antimicrobial resistance, and illicit drug consumption. Wastewater surveillance, a quickly advancing Frontier in environmental science, is becoming a new tool to enhance public health, improve …

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Technology Meets Tils: Deciphering T Cell Function In The -Omics Era, William H Hudson, Andreas Wieland Jan 2023

Technology Meets Tils: Deciphering T Cell Function In The -Omics Era, William H Hudson, Andreas Wieland

Faculty, Staff and Students Publications

T cells are at the centerstage of cancer immunology due to their ability to recognize mutations within tumor cells and directly mediate cancer cell killing. Immunotherapies to rejuvenate exhausted T cell responses have transformed the clinical management of several malignancies. In parallel, the development of novel multidimensional analysis platforms such as single-cell RNA-sequencing and high-dimensional flow cytometry has yielded unprecedented insights into immune cell biology. This convergence has revealed substantial heterogeneity of tumor-infiltrating immune cells, both within single tumors, across tumor types, and among cancer patients. Here, we discuss the opportunities and challenges of studying the complex tumor microenvironment with …

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Histopathologic And Proteogenomic Heterogeneity Reveals Features Of Clear Cell Renal Cell Carcinoma Aggressiveness, Yize Li, Tung-Shing M Lih, Saravana M Dhanasekaran, Rahul Mannan, Lijun Chen, Marcin Cieslik, Yige Wu, Rita Jiu-Hsien Lu, David J Clark, Iga Kołodziejczak, Runyu Hong, Siqi Chen, Yanyan Zhao, Seema Chugh, Wagma Caravan, Nataly Naser Al Deen, Noshad Hosseini, Chelsea J Newton, Karsten Krug, Yuanwei Xu, Kyung-Cho Cho, Yingwei Hu, Yuping Zhang, Chandan Kumar-Sinha, Weiping Ma, Anna Calinawan, Matthew A Wyczalkowski, Michael C Wendl, Yuefan Wang, Shenghao Guo, Cissy Zhang, Anne Le, Aniket Dagar, Alex Hopkins, Hanbyul Cho, Felipe Da Veiga Leprevost, Xiaojun Jing, Guo Ci Teo, Wenke Liu, Melissa A Reimers, Russell Pachynski, Alexander J Lazar, Arul M Chinnaiyan, Brian A Van Tine, Bing Zhang, Karin D Rodland, Gad Getz, D R Mani, Pei Wang, Feng Chen, Galen Hostetter, Mathangi Thiagarajan, W Marston Linehan, David Fenyö, Scott D Jewell, Gilbert S Omenn, Rohit Mehra, Maciej Wiznerowicz, Ana I Robles, Mehdi Mesri, Tara Hiltke, Eunkyung An, Henry Rodriguez, Daniel W Chan, Christopher J Ricketts, Alexey I Nesvizhskii, Hui Zhang, Li Ding, Clinical Proteomic Tumor Analysis Consortium Jan 2023

Histopathologic And Proteogenomic Heterogeneity Reveals Features Of Clear Cell Renal Cell Carcinoma Aggressiveness, Yize Li, Tung-Shing M Lih, Saravana M Dhanasekaran, Rahul Mannan, Lijun Chen, Marcin Cieslik, Yige Wu, Rita Jiu-Hsien Lu, David J Clark, Iga Kołodziejczak, Runyu Hong, Siqi Chen, Yanyan Zhao, Seema Chugh, Wagma Caravan, Nataly Naser Al Deen, Noshad Hosseini, Chelsea J Newton, Karsten Krug, Yuanwei Xu, Kyung-Cho Cho, Yingwei Hu, Yuping Zhang, Chandan Kumar-Sinha, Weiping Ma, Anna Calinawan, Matthew A Wyczalkowski, Michael C Wendl, Yuefan Wang, Shenghao Guo, Cissy Zhang, Anne Le, Aniket Dagar, Alex Hopkins, Hanbyul Cho, Felipe Da Veiga Leprevost, Xiaojun Jing, Guo Ci Teo, Wenke Liu, Melissa A Reimers, Russell Pachynski, Alexander J Lazar, Arul M Chinnaiyan, Brian A Van Tine, Bing Zhang, Karin D Rodland, Gad Getz, D R Mani, Pei Wang, Feng Chen, Galen Hostetter, Mathangi Thiagarajan, W Marston Linehan, David Fenyö, Scott D Jewell, Gilbert S Omenn, Rohit Mehra, Maciej Wiznerowicz, Ana I Robles, Mehdi Mesri, Tara Hiltke, Eunkyung An, Henry Rodriguez, Daniel W Chan, Christopher J Ricketts, Alexey I Nesvizhskii, Hui Zhang, Li Ding, Clinical Proteomic Tumor Analysis Consortium

Faculty, Staff and Students Publications

Clear cell renal cell carcinomas (ccRCCs) represent ∼75% of RCC cases and account for most RCC-associated deaths. Inter- and intratumoral heterogeneity (ITH) results in varying prognosis and treatment outcomes. To obtain the most comprehensive profile of ccRCC, we perform integrative histopathologic, proteogenomic, and metabolomic analyses on 305 ccRCC tumor segments and 166 paired adjacent normal tissues from 213 cases. Combining histologic and molecular profiles reveals ITH in 90% of ccRCCs, with 50% demonstrating immune signature heterogeneity. High tumor grade, along with BAP1 mutation, genome instability, increased hypermethylation, and a specific protein glycosylation signature define a high-risk disease subset, where UCHL1 …

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Technology Meets Tils: Deciphering T Cell Function In The -Omics Era, William H Hudson, Andreas Wieland Jan 2023

Technology Meets Tils: Deciphering T Cell Function In The -Omics Era, William H Hudson, Andreas Wieland

Faculty, Staff and Students Publications

T cells are at the centerstage of cancer immunology due to their ability to recognize mutations within tumor cells and directly mediate cancer cell killing. Immunotherapies to rejuvenate exhausted T cell responses have transformed the clinical management of several malignancies. In parallel, the development of novel multidimensional analysis platforms such as single-cell RNA-sequencing and high-dimensional flow cytometry has yielded unprecedented insights into immune cell biology. This convergence has revealed substantial heterogeneity of tumor-infiltrating immune cells, both within single tumors, across tumor types, and among cancer patients. Here, we discuss the opportunities and challenges of studying the complex tumor microenvironment with …

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Interdependent Progression Of Bidirectional Sister Replisomes In E Coli, Po Jui Chen, Anna B Mcmullin, Bryan J Visser, Qian Mei, Susan M Rosenberg, David Bates Jan 2023

Interdependent Progression Of Bidirectional Sister Replisomes In E Coli, Po Jui Chen, Anna B Mcmullin, Bryan J Visser, Qian Mei, Susan M Rosenberg, David Bates

Faculty, Staff and Students Publications

Bidirectional DNA replication complexes initiated from the same origin remain colocalized in a factory configuration for part or all their lifetimes. However, there is little evidence that sister replisomes are functionally interdependent, and the consequence of factory replication is unknown. Here, we investigated the functional relationship between sister replisomes in Escherichia coli, which naturally exhibits both factory and solitary configurations in the same replication cycle. Using an inducible transcription factor roadblocking system, we found that blocking one replisome caused a significant decrease in overall progression and velocity of the sister replisome. Remarkably, progression was impaired only if the block …

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Docosahexaenoic Acid Stability In Ready-To-Use Therapeutic Food, Genevieve James, Kevin Stephenson, Meghan Callaghan-Gillespie, Mohamed Tabita Kamara, Hui Gyu Park, J Thomas Brenna, Mark J Manary Jan 2023

Docosahexaenoic Acid Stability In Ready-To-Use Therapeutic Food, Genevieve James, Kevin Stephenson, Meghan Callaghan-Gillespie, Mohamed Tabita Kamara, Hui Gyu Park, J Thomas Brenna, Mark J Manary

2020-Current year OA Pubs

Ready-to-use therapeutic food (RUTF) is used to treat young children diagnosed with severe acute malnutrition. RUTF with low and balanced linoleic and alpha-linolenic acid, plus omega-3 docosahexaenoic acid (DHA), supports long-term cognitive recovery. DHA is prone to degradation due to peroxidation, possibly exacerbated by the iron inherently in RUTF. Our goals were to prepare benchtop and manufacturing scale of RUTF formulations that include DHA and measure its retention. Twenty-seven RUTF formulas with base ingredients, including oats, high oleic or commodity peanuts, and encapsulated or oil-based DHA at various levels were prepared at benchtop scale, followed by seven months of climate-controlled …

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Gene-Folic Acid Interactions And Risk Of Conotruncal Heart Defects: Results From The National Birth Defects Prevention Study, Daniel M Webber, Ming Li, Stewart L Macleod, Xinyu Tang, Joseph W Levy, Mohammad A Karim, Stephen W Erickson, Charlotte A Hobbs, The National Birth Defects Prevention Study Jan 2023

Gene-Folic Acid Interactions And Risk Of Conotruncal Heart Defects: Results From The National Birth Defects Prevention Study, Daniel M Webber, Ming Li, Stewart L Macleod, Xinyu Tang, Joseph W Levy, Mohammad A Karim, Stephen W Erickson, Charlotte A Hobbs, The National Birth Defects Prevention Study

2020-Current year OA Pubs

Conotruncal heart defects (CTDs) are heart malformations that affect the cardiac outflow tract and typically cause significant morbidity and mortality. Evidence from epidemiological studies suggests that maternal folate intake is associated with a reduced risk of heart defects, including CTD. However, it is unclear if folate-related gene variants and maternal folate intake have an interactive effect on the risk of CTDs. In this study, we performed targeted sequencing of folate-related genes on DNA from 436 case families with CTDs who are enrolled in the National Birth Defects Prevention Study and then tested for common and rare variants associated with CTD. …

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Isolation And Identification Of Bacterial Causes Of Diarrhea In Children Less Than 2 Years Old In Al-Muthanna Governorate, Karima Al Salihi, Mohammed Hassan Younise Jan 2023

Isolation And Identification Of Bacterial Causes Of Diarrhea In Children Less Than 2 Years Old In Al-Muthanna Governorate, Karima Al Salihi, Mohammed Hassan Younise

Muthanna Medical Journal

Diarrhea is the second leading cause of children’s death under five years of age worldwide. The most common microbiological causes of gastroenteritis vary by age group, geographic region, and type of diarrhea. This study designed to identify the bacterial causes of children’s diarrhea under two years of age in Samawah /Al-Muthanna Governorate. Out of 84 patients, 21 sterile stool swabs were collected from children suffering from diarrhea in the Maternity and Children Hospital in Samawah for the period from 1 to 31 December 2021. Samples were cultured on selective diagnostic culture media. Antibiotic sensitivity test was performed for bacterial isolates …

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