Digital Commons Network^™

Using Dielectric Scatters To Selectively Excite Embedded Eigenstates In Cavity Resonators, Olugbenga Joshua Gbidi

Theses and Dissertations

Bound states in the continuum (BICs) are waves that remain in the continuous spectrum of radiating waves that carry energy, however, still localized within the spectrum. BICs, also embedded eigenmodes, exhibit high quality factors that have been observed in optical and acoustic waveguides, photonic structures, and other material systems. Presently, there are limited means to select these BICs in terms of the quality factor and their excitation. In this work, we show that a different type of BIC, Quasi-BICs (Q-BICs), in open resonators can have their quality attuned by introducing embedded scatters. Using microwave cavities and dielectric scatters as an …

Inhibition Of Ribosome Assembly Factor Pno1 By Crispr/Cas9 Technique Suppresses Lung Adenocarcinoma And Notch Pathway: Clinical Application, Sanjit K. Roy, Shivam Srivastava, Andrew Hancock, Anju Shrivastava, Jason Morvant, Sharmila Shankar, Rakesh K. Srivastava

School of Medicine Faculty Publications

Growth is crucially controlled by the functional ribosomes available in cells. To meet the enhanced energy demand, cancer cells re-wire and increase their ribosome biogenesis. The RNA-binding protein PNO1, a ribosome assembly factor, plays an essential role in ribosome biogenesis. The purpose of this study was to examine whether PNO1 can be used as a biomarker for lung adenocarcinoma and also examine the molecular mechanisms by which PNO1 knockdown by CRISPR/Cas9 inhibited growth and epithelial–mesenchymal transition (EMT). The expression of PNO1 was significantly higher in lung adenocarcinoma compared to normal lung tissues. PNO1 expression in lung adenocarcinoma patients increased with …

Knight In Shining Armor, Wayne Baker

Materials from the University of Dayton Magazine Website

University of Dayton graduate is a critical part of Buffalo Bills player Damar Hamlin's care team at Cincinnati hospital.

Classification Of Covid-19 Symptoms Using Multilayerperceptron, Mohd Arfian Ismail, Nurulain Nusrah Mohd Azam, Mohd Saberi Mohamad, Ashraf Osman Ibrahim, Shermina Jeba

Iraqi Journal for Computer Science and Mathematics

The COVID-19 virus had easily affected people worldwide through direct contact. Individualsdiagnosed with positive COVID-19 virus may be affected with many symptoms, such as fever, tiredness, dry cough,difficulty in breathing, sore throat, chest pain, nasal congestion, runny nose, and diarrhea. An individual can alsobe diagnosed with COVID-19 even when he does not have any symptoms or be in contact with an infected person.Data classification was required due to the size of COVID-19 data that will be analyzed for future countermeasuresdetermination. Some problems in data classification occurred due to unorganized data, such as time consumption,human error in complexity of symptom features …

A Reframed Consistent Ethic Of Life On Nuclear Energy: Exploring The Moral Implications Of The Revival Of The Bataan Nuclear Power Plant, Archie R. Magarao

Landas

This paper critically examines the moral implications of reviving the Bataan Nuclear Power Plant (BNPP) through the lens of the Reframed Consistent Ethic of Life (RCEL). While the Philippine government highlights its potential economic benefits, the study raises serious concerns about nuclear waste and its risks to human and nonhuman life. It evaluates both the advantages and dangers of nuclear energy, emphasizing threats to ecological integrity and long-term safety. The paper also questions the adequacy of existing plans for nuclear waste disposal, particularly in light of geopolitical and security challenges. In response, it proposes key moral perspectives: rethinking God’s presence …

Modeling And Analyzing Homogeneous Tumor Growth Under Virotherapy, Chayu Yang, Jin Wang

Department of Mathematics: Faculty Publications

We present a mathematical model based on ordinary differential equations to investigate the spatially homogeneous state of tumor growth under virotherapy. The model emphasizes the interaction among the tumor cells, the oncolytic viruses, and the host immune system that generates both innate and adaptive immune responses. We conduct a rigorous equilibrium analysis and derive threshold conditions that determine the growth or decay of the tumor under various scenarios. Numerical simulation results verify our analytical predictions and provide additional insight into the tumor growth dynamics.

Functional Impact Of A Cancer-Related Variant In Human Δ1‑Pyrroline-5-Carboxylate Reductase 1, Oseeyi I. Daudu, Kaylen R. Meeks, Lu Zhang, Javier Seravalli, John J. Tanner, Donald F. Becker

Department of Biochemistry: Faculty Publications

Pyrroline-5-carboxylate reductase (PYCR) is a proline biosynthetic enzyme that catalyzes the NAD(P)H-dependent reduction of Δ¹-pyrroline-5-carboxylate (P5C) to proline. Humans have three PYCR isoforms, with PYCR1 often upregulated in different types of cancers. Here, we studied the biochemical and structural properties of the Thr171Met variant of PYCR1, which is found in patients with malignant melanoma and lung adenocarcinoma. Although PYCR1 is strongly associated with cancer progression, characterization of a PYCR1 variant in cancer patients has not yet been reported. Thr171 is conserved in all three PYCR isozymes and is located near the P5C substrate binding site. We found that …

Something Smells Fishy: How Lipid Mediators Impact The Maternal–Fetal Interface And Neonatal Development, Maranda Thompson, Arzu Ulu, Maheswari Mukherjee, Ana G. Yuil-Valdes, Melissa Thoene, Matthew Van Ormer, Rebecca Slotkowski, Teri Mauch, Ann Anderson-Berry, Corrine K. Hanson, Tara M. Nordgren, Sathish Kumar Natarajan

Department of Nutrition and Health Sciences: Faculty Publications

Normal pregnancy relies on inflammation for implantation, placentation, and parturition, but uncontrolled inflammation can lead to poor maternal and infant outcomes. Maternal diet is one modifiable factor that can impact inflammation. Omega-3 and -6 fatty acids obtained through the diet are metabolized into bioactive compounds that effect inflammation. Recent evidence has shown that the downstream products of omega-3 and -6 fatty acids may influence physiology during pregnancy. In this review, the current knowledge relating to omega-3 and omega-6 metabolites during pregnancy will be summarized.

Something Smells Fishy: How Lipid Mediators Impact The Maternal–Fetal Interface And Neonatal Development, Maranda Thompson, Arzu Ulu, Maheswari Mukherjee, Ana G. Yuil-Valdes, Melissa K. Thoene, Matthew Van Ormer, Rebecca Slotkowski, Teri Mauch, Ann Anderson-Berry, Corrine K. Hanson, Tara M. Nordgren, Sathish Kumar Natarajan

Department of Nutrition and Health Sciences: Faculty Publications

Normal pregnancy relies on inflammation for implantation, placentation, and parturition, but uncontrolled inflammation can lead to poor maternal and infant outcomes. Maternal diet is one modifiable factor that can impact inflammation. Omega-3 and -6 fatty acids obtained through the diet are metabolized into bioactive compounds that effect inflammation. Recent evidence has shown that the downstream products of omega-3 and -6 fatty acids may influence physiology during pregnancy. In this review, the current knowledge relating to omega-3 and omega-6 metabolites during pregnancy will be summarized.

More-Speed: Enhancing Protein Activity Prediction From Dna Sequences, Samahe Al Janabi, Zena Kadhuim

Iraqi Journal for Computer Science and Mathematics

This work presents More-SPEED, a novel model for accurately predicting protein activity while minimizing computational demands. Leveraging optimized structures anddata preprocessing techniques, More-SPEED achieves high accuracy in protein activity prediction. The model incorporates thedata compression three dimension (DC-3D)layer, utilizing the graph mining pattern-fist frequency graph mining (GMP-FFGM)algorithmfor efficient preprocessing of complex Deoxyribonucleic acid (DNA)sequence datasets. Additionally, the deterministic structure network using the natural-inspired optimization algorithm calledWhale Optimization Algorithm(DSN-WOA)structure optimizes parameters of the Biological dynamic long short term memory (BDLSTM)model, reducing processing time and eliminating manual parameter selection. The BDLSTM layer plays a crucial role in matching codons and predicting protein …

An Age-Dependent Immuno-Epidemiological Model With Distributed Recovery And Death Rates, Samiran Ghosh, Vitaly Volpert, Malay Banerjee

Faculty, Staff and Student Publications

The work is devoted to a new immuno-epidemiological model with distributed recovery and death rates considered as functions of time after the infection onset. Disease transmission rate depends on the intra-subject viral load determined from the immunological submodel. The age-dependent model includes the viral load, recovery and death rates as functions of age considered as a continuous variable. Equations for susceptible, infected, recovered and dead compartments are expressed in terms of the number of newly infected cases. The analysis of the model includes the proof of the existence and uniqueness of solution. Furthermore, it is shown how the model can …

Predictors Of Success In Establishing Orthotopic Patient-Derived Xenograft Models Of Triple Negative Breast Cancer, Gloria V Echeverria, Shirong Cai, Yizheng Tu, Jiansu Shao, Emily Powell, Abena B Redwood, Yan Jiang, Aaron Mccoy, Amanda L Rinkenbaugh, Rosanna Lau, Alexander J Trevarton, Chunxiao Fu, Rebekah Gould, Elizabeth E Ravenberg, Lei Huo, Rosalind Candelaria, Lumarie Santiago, Beatriz E Adrada, Deanna L Lane, Gaiane M Rauch, Wei T Yang, Jason B White, Jeffrey T Chang, Stacy L Moulder, W Fraser Symmans, Susan G Hilsenbeck, Helen Piwnica-Worms

Faculty, Staff and Student Publications

Patient-derived xenograft (PDX) models of breast cancer are an effective discovery platform and tool for preclinical pharmacologic testing and biomarker identification. We established orthotopic PDX models of triple negative breast cancer (TNBC) from the primary breast tumors of patients prior to and following neoadjuvant chemotherapy (NACT) while they were enrolled in the ARTEMIS trial (NCT02276443). Serial biopsies were obtained from patients prior to treatment (pre-NACT), from poorly responsive disease after four cycles of Adriamycin and cyclophosphamide (AC, mid-NACT), and in cases of AC-resistance, after a 3-month course of different experimental therapies and/or additional chemotherapy (post-NACT). Our study cohort includes a …

Efficacy Of Eltrombopag With Immunosuppressive Therapy For Children With Acquired Aplastic Anemia, Yufei Zhao, Wenrui Yang, Xin Zhao, Xiangrong Hu, Jing Hu, Xu Liu, Jianping Li, Lei Ye, Youzhen Xiong, Yang Yang, Baohang Zhang, Xiaoxia Li, Xiawan Yang, Yimeng Shi, Guangxin Peng, Yuan Li, Huihui Fan, Kang Zhou, Liping Jing, Li Zhang, Fengkui Zhang

Faculty, Staff and Student Publications

BACKGROUND: Eltrombopag (EPAG), an oral thrombopoietin receptor agonist (TPO-RA), has been proven to improve the hematologic response without increasing toxic effects as a first-line therapy combined with standard immunosuppressive treatment (IST) in adults with severe aplastic anemia (SAA). Nevertheless, the clinical evidence on the efficacy of EPAG in children with acquired aplastic anemia is limited and controversial.

METHODS: We performed a single-center, retrospective study to analyze the clinical outcomes of fifteen patients aged ≤18 years with newly diagnosed acquired SAA who received first-line IST and EPAG (EPAG group) compared with those of forty-five patients who received IST alone (IST group) …

Diverticular Disease And Cancer Risk: More Than A Gut Feeling, Veronika Fedirko, Scott Kopetz, Carrie R Daniel

Faculty, Staff and Student Publications

No abstract provided.

Higher Dietary Vitamin K Intake Is Associated With Better Physical Function And Lower Long-Term Injurious Falls Risk In Community-Dwelling Older Women, Marc Sim, C. Smith, Nicky P. Bondonno, Simone Radavelli-Bagatini, Lauren C. Blekkenhorst, Jack Dalla Via, R. Mccormick, K. Zhu, Jonathan M. Hodgson, R. L. Prince, Joshua R. Lewis

Research outputs 2022 to 2026

Background: In recent years, a potential beneficial role of Vitamin K in neuromuscular function has been recognised. However, the optimal dietary intake of Vitamin K to support muscle function in the context of falls prevention remains unknown. Objective: To examine the relationship of dietary Vitamin K1 and K2 with muscle function and long-term injurious fall-related hospitalisations in older women. Design: Cohort study. Participants: 1347 community-dwelling older Australian women ≥ 70 years. Measurements: A new Australian Vitamin K nutrient database, supplemented with published data, was used to calculate Vitamin K1 and K2 intake from a validated food frequency questionnaire at baseline …

Impact Of Enteropathogens On Faltering Growth In A Resource-Limited Setting, Furqan Kabir, Junaid Iqbal, Zehra Jamil, Najeeha Talat Iqbal, Fatima Aziz, Adil Kalam, Sahrish Muneer, Aneeta Hotwani, Sheraz Ahmed, Fayyaz Umrani, Sana Syed, Kamran Sadiq, Syed Asad Ali

Department of Paediatrics and Child Health

Introduction: Environmental enteropathy is an important contributor to childhood malnutrition in the developing world. Chronic exposure to fecal pathogens leads to alteration in intestinal structure and function, resulting in impaired gut immune function, malabsorption, and growth faltering leading to environmental enteropathy.
Methods: A community-based intervention study was carried out on children till 24 months of age in Matiari district, Pakistan. Blood and fecal specimens were collected from the enrolled children aged 3-6 and 9 months. A real-time PCR-based TaqMan array card (TAC) was used to detect enteropathogens.
Results: Giardia, Campylobacter spp., enteroaggregative Escherichia coli (EAEC), Enteropathogenic Escherichia coli (EPEC), …

Plasma Protein Profiling Analysis In Patients With Atrial Fibrillation Before And After Three Different Ablation Techniques, Menglu Lin, Yangyang Bao, Zunhui Du, Yanting Zhou, Ning Zhang, Changjian Lin, Yinyin Xie, Ruihong Zhang, Qiheng Li, Jinwei Quan, Tingfang Zhu, Yuan Xie, Cathy Xu, Yun Xie, Yue Wei, Qingzhi Luo, Wenqi Pan, Lingjie Wang, Tianyou Ling, Qi Jin, Liqun Wu, Tong Yin, Yucai Xie

Student Publications

Background: There are controversies on the pathophysiological alteration in patients with atrial fibrillation (AF) undergoing pulmonary vein isolation using different energy sources.

Objectives: We evaluated the changes in plasma proteins in acute phase post-ablation in patients receiving cryoballoon ablation, radiofrequency balloon ablation, or radiofrequency ablation.

Methods: Blood samples from eight healthy controls and 24 patients with AF were taken on the day of admission, day 1, and day 2 post-ablation and analyzed by the Olink proximity extension assay. Proteins were identified and performed with enrichment analysis. Protein-protein interaction network and module analysis were conducted using Cytoscape software.

Results: Of 181 …

Abiotic Stress Experiments Need A Reality Check To Improve Translation To The Field, Anne Plessis

School of Biological and Marine Sciences

No abstract provided.

Corrigendum: The Presence Of Silver Nanoparticles Reduces Demand For Dissolved Phosphorus To The Benefit Of Biological Nitrogen Fixation In The Coastal Eastern Mediterranean Sea, Ap Rees, E Faraggiana, K Tait, M Celussi, E Dafnomilli, V Manna, A Manning, P Pitta, A Tsiola, S Živanović

School of Biological and Marine Sciences

No abstract provided.

Differential Co-Expression Networks Of The Gut Microbiota Are Associated With Depression And Anxiety Treatment Resistance Among Psychiatric Inpatients, Dominique S Thompson, Chenlian Fu, Tanmay Gandhi, J Christopher Fowler, B Christopher Frueh, Benjamin L Weinstein, Joseph Petrosino, Julia K Hadden, Marianne Carlson, Cristian Coarfa, Alok Madan

Faculty, Staff and Students Publications

BACKGROUND: Comorbid anxiety and depression are common and are associated with greater disease burden than either alone. Our recent efforts have identified an association between gut microbiota dysfunction and severity of anxiety and depression. In this follow-up, we applied Differential Co-Expression Analysis (DiffCoEx) to identify potential gut microbiota biomarker(s) candidates of treatment resistance among psychiatric inpatients.

METHODS: In a sample of convenience, 100 psychiatric inpatients provided clinical data at admission and discharge; fecal samples were collected early during the hospitalization. Whole genome shotgun sequencing methods were used to process samples. DiffCoEx was used to identify clusters of microbial features significantly …

A Bioengineered Probiotic For The Oral Delivery Of A Peptide Kv13 Channel Blocker To Treat Rheumatoid Arthritis, Yuqing Wang, Duolong Zhu, Laura C Ortiz-Velez, Jacob L Perry, Michael W Pennington, Joseph M Hyser, Robert A Britton, Christine Beeton

Faculty, Staff and Students Publications

New therapeutics that combine efficacy with limited side effects and can be delivered noninvasively are needed to adequately treat patients with rheumatoid arthritis (RA) and other autoimmune diseases. Kv1.3 channel-expressing CCR7− effector memory T (TEM) lymphocytes are significant players in the pathogenesis of multiple autoimmune diseases, and blocking Kv1.3 reduces disease severity in rat models of RA and patients with plaque psoriasis. However, peptide therapeutics require repeated injections, reducing patient compliance. We used a bioengineered Lactobacillus reuteri as an oral delivery method of a Kv1.3 blocker for immunomodulation in rat models of atopic dermatitis and RA. This study demonstrates a …

Procalcitonin And C-Reactive Protein Levels Among Covid-19 Patients In Sulaymaniyah, Karmand Qadir Hamad Amin, Makwan Mohammed Abdulkareem

Muthanna Medical Journal

COVID-19 is a viral disease that affects multiple body organs. The objective of this study is Investigating the role of PCT and CRP in predicting the outcome of patients with COVID-19. Cross-sectional prospective study including 135 patients with SARS-CoV-2 confirmed by RT-PCR. Serum level of PCT and CRP are measured at admission and on day 10 post-admission. Patients are followed up for one month. The mean level of PCT on day 1 was 0.1±0.28 ng/ml compared with 0.3±1.27 ng/ml on day 10. Respectively, the mean serum level of CRP on day 1 and day 10 was 113.57±89.88mg/L and 44.76±43.29 mg/L. …

Childhood Adversities And Risk Of Posttraumatic Stress Disorder And Major Depression Following A Motor Vehicle Collision In Adulthood, H N Ziobrowski, S L House, D M Barch, Et Al.

2020-Current year OA Pubs

AIMS: Childhood adversities (CAs) predict heightened risks of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) among people exposed to adult traumatic events. Identifying which CAs put individuals at greatest risk for these adverse posttraumatic neuropsychiatric sequelae (APNS) is important for targeting prevention interventions.

METHODS: Data came from

RESULTS: Most participants (90.9%) reported at least rarely having experienced some CA. Ever experiencing each CA other than emotional neglect was univariably associated with 3-month APNS (RRs = 1.31-1.60). Each CA frequency was also univariably associated with 3-month APNS (RRs = 1.65-2.45). In multivariable models, joint associations of CAs with 3-month …

Dry Eye Disease In Mice Activates Adaptive Corneal Epithelial Regeneration Distinct From Constitutive Renewal In Homeostasis, Joseph B Lin, Xiaolei Shen, Charles W Pfeifer, Fion Shiau, Andrea Santeford, Philip A Ruzycki, Brian S Clark, Qin Liu, Andrew J W Huang, Rajendra S Apte

2020-Current year OA Pubs

Many epithelial compartments undergo constitutive renewal in homeostasis but activate unique regenerative responses following injury. The clear corneal epithelium is crucial for vision and is renewed from limbal stem cells (LSCs). Using single-cell RNA sequencing, we profiled the mouse corneal epithelium in homeostasis, aging, diabetes, and dry eye disease (DED), where tear deficiency predisposes the cornea to recurrent injury. In homeostasis, we capture the transcriptional states that accomplish continuous tissue turnover. We leverage our dataset to identify candidate genes and gene networks that characterize key stages across homeostatic renewal, including markers for LSCs. In aging and diabetes, there were only …

Coping Mechanisms In Graduate School: A Discipline Comparison, Sandra P. Montenegro

The Pegasus Review: UCF Undergraduate Research Journal

The current study aimed to provide an overview of graduate students’ stress and coping mechanisms. Per self-reported questionnaires, participants (N=95) rated their experiences with academic-related stressors, common coping mechanisms, and strain outcomes (somatic symptoms, insomnia, and burnout). This study found that task-related stressors were the most prevalent for graduate schoolwork. More specifically, graduate students in STEM, Arts & Humanities, and Social Sciences rated the amount and difficulty of the tasks (quantitative and qualitative properties of tasks) as the highest stressors in graduate school. The preferred coping strategies across all fields were planning and emotional coping. Additionally, students in STEM reported …

“Listen To Me” – A Systematic Literature Review About Learning From Others’ Failure Narrations, Verena Liszt-Rohlf

International Journal for Business Education

The dedicated stream of learning from others’ failure has gained increasing attention in entrepreneurship education research and—because of the COVID-19 crisis—among practitioners. The emerging literature on entrepreneurship education addresses this important phenomenon but lacks specific theoretical underpinnings; its new approaches to and empirical inquiry are one-sided. Therefore, a systematic literature review is warranted to provide a more comprehensive view of learning from others’ entrepreneurial failures and to develop a research model. Unprecedentedly, the author explores the type of research streams and gaps that can be included in a research model for entrepreneurship education research in the area of learning from …

Improvement Of Long Covid Symptoms Over One Year., Carlos R Oliveira, Leonard A Jason, Derya Unutmaz, Lucinda Bateman, Suzanne D Vernon

Faculty Research 2023

IMPORTANCE: Early and accurate diagnosis and treatment of Long COVID, clinically known as post-acute sequelae of COVID-19 (PASC), may mitigate progression to chronic diseases such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our objective was to determine the utility of the DePaul Symptom Questionnaire (DSQ) to assess the frequency and severity of common symptoms of ME/CFS, to diagnose and monitor symptoms in patients with PASC.

METHODS: This prospective, observational cohort study enrolled 185 people that included 34 patients with PASC that had positive COVID-19 test and persistent symptoms of >3 months and 151 patients diagnosed with ME/CFS. PASC patients were followed …

Faculty Senate Monthly Packet January 2023, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The January 9, 2023 Monthly packet includes the January agenda and appendices and the Faculty Senate minutes and attachments from the meeting held on December 5, 2022.

Framing Esports’ Jedi Issues: A Case Study In Media Irresponsibility, David Painter, Brittani Sahm

Faculty Publications

Purpose: This investigation analyzes Asian, European, and North American coverage of esports’ justice, equity, diversity, and inclusion (JEDI) issues as a case study of media organizations’ communications on these topics.

Design/methodology/approach: This quantitative content analysis describes coverage of esports’ race, gender, age, and social class issues to draw inferences about media organizations’ abilities to meet their social responsibilities when reporting on organizational JEDI issues.

Findings: There were significant differences across continents; however, most stories only mentioned gender and age, seldom noting esports’ race or social class issues.

Research limitations/implications: Although all stories analyzed were published in English, the findings extend …

Reverse Social Impact Of Oil Palm Plantation Expansion: A Study Of Three Communities In Jambi, Indonesia, Pahmi Pahmi, Budhi Gunawan, Johan Iskandar, Rini Soemarwoto

Forest and Society

Studies on the social impacts of oil palm development have focused on various communities with distinct characteristics. Due to the rarity of comparative investigations, this study aimed to examine the impact of oil palm plantation expansion on the Suku Anak Dalam, Jambi Malay, and the Javanese transmigrant, the three communities with different socio-economic characteristics. In-depth interviews and observations were conducted to understand the communities' interaction and dependence on forest resources. The study also conducted a household census to assess 67 Malay and 66 Javanese transmigrant families. However, a household census could not be conducted to asses 45 families of …