Digital Commons Network^™

Investigating The Absence Of A Dietary Response At The Neuromuscular Junction In Larval Drosophila Melanogaster, Suzanna Louise Marbach

Honors Program Theses and Research Projects

Research in Drosophila melanogaster (D. melanogaster) has been growing in order to identify the fundamental processes of human disorders of the central nervous system such as Alzheimer’s disease, diabetes, and other neurological disorders at a molecular level. Altered insulin signaling itself has been linked to widespread nervous system dysfunction including cognitive dysfunction, neuropathies, and susceptibility to neurodegenerative disease. However, knowledge of the cellular mechanisms underlying the effects of insulin on nervous system function is still incomplete. The focus behind investigating the insulin signaling pathway is derived from our observations in the adult D. melanogaster neuromuscular junction (NMJ) to changes in …

Antibody-Drug Conjugates In Lung Cancer: Dawn Of A New Era?, Niamh Coleman, Timothy A Yap, John V Heymach, Funda Meric-Bernstam, Xiuning Le

Faculty, Staff and Student Publications

Antibody-drug conjugates (ADCs) are one of fastest growing classes of oncology drugs in modern drug development. By harnessing the powers of both cytotoxic chemotherapy and targeted therapy, ADCs are unique in offering the potential to deliver highly potent cytotoxic agents to cancer cells which express a pre-defined cell surface target. In lung cancer, the treatment paradigm has shifted dramatically in recent years, and now ADCs are now joining the list as potential options for lung cancer patients. Since 2020, the first ADC for NSCLC patients has been FDA-approved (trastuzumab deruxtecan) and two ADCs have been granted FDA Breakthrough Therapy Designation, …

Reconstructing Mutational Lineages In Breast Cancer By Multi-Patient-Targeted Single-Cell Dna Sequencing, Jake Leighton, Min Hu, Emi Sei, Funda Meric-Bernstam, Nicholas E Navin

Faculty, Staff and Student Publications

Single-cell DNA sequencing (scDNA-seq) methods are powerful tools for profiling mutations in cancer cells; however, most genomic regions sequenced in single cells are non-informative. To overcome this issue, we developed a multi-patient-targeted (MPT) scDNA-seq method. MPT involves first performing bulk exome sequencing across a cohort of cancer patients to identify somatic mutations, which are then pooled together to develop a single custom targeted panel for high-throughput scDNA-seq using a microfluidics platform. We applied MPT to profile 330 mutations across 23,500 cells from 5 patients with triple negative-breast cancer (TNBC), which showed that 3 tumors were monoclonal and 2 tumors were …

Checkpoint Inhibitor Immune-Related Adverse Events: A Focused Review On Autoantibodies And B Cells As Biomarkers, Advancements And Future Possibilities, John Taylor, Aesha Gandhi, Elin Gray, Pauline Zaenker

Research outputs 2022 to 2026

The use of immune checkpoint inhibitors (ICIs) has evolved rapidly with unprecedented treatment benefits being obtained for cancer patients, including improved patient survival. However, over half of the patients experience immune related adverse events (irAEs) or toxicities, which can be fatal, affect the quality of life of patients and potentially cause treatment interruption or cessation. Complications from these toxicities can also cause long term irreversible organ damage and other chronic health conditions. Toxicities can occur in various organ systems, with common observations in the skin, rheumatologic, gastrointestinal, hepatic, endocrine system and the lungs. These are not only challenging to manage …

Externalities,Scarcity And Abundance, Brett M. Frischmann, Giovanni B. Ramello

Faculty Publications

Introduction: Do externalities work and matter differently in a world of scarcity vs. a world of abundance? In this article, we critically examine the economic phenomena of externalities. The concept of externality, an important idea in economics and law, is useful in exploring the complex and dynamic relationships between resource supply and human flourishing within various sociotechnical systems.

Methods: First, we define the basic concept and explain why it is fundamental to economic analysis of complex social environments Second, we briefly survey the intellectual history of externalities with the goal of tying together a few different strands of economic theory …

Combining Ivus + Oct Data, Biomechanical Models And Machine Learning Method For Accurate Coronary Plaque Morphology Quantification And Cap Thickness And Stress/Strain Index Predictions, Rui Lv, Liang Wang, Akiko Maehara, Mitsuaki Matsumura, Xiaoya Guo, Habib Samady, Don P Giddens, Jie Zheng, Gary S Mintz, Dalin Tang

2020-Current year OA Pubs

Assessment and prediction of vulnerable plaque progression and rupture risk are of utmost importance for diagnosis, management and treatment of cardiovascular diseases and possible prevention of acute cardiovascular events such as heart attack and stroke. However, accurate assessment of plaque vulnerability assessment and prediction of its future changes require accurate plaque cap thickness, tissue component and structure quantifications and mechanical stress/strain calculations. Multi-modality intravascular ultrasound (IVUS), optical coherence tomography (OCT) and angiography image data with follow-up were acquired from ten patients to obtain accurate and reliable plaque morphology for model construction. Three-dimensional thin-slice finite element models were constructed for 228 …

Subtypes Of Relapsing-Remitting Multiple Sclerosis Identified By Network Analysis, Quentin Howlett-Prieto, Chelsea Oommen, Michael D. Carrithers, Donald C. Wunsch, Daniel B. Hier

Electrical and Computer Engineering Faculty Research & Creative Works

We used network analysis to identify subtypes of relapsing-remitting multiple sclerosis subjects based on their cumulative signs and symptoms. The electronic medical records of 113 subjects with relapsing-remitting multiple sclerosis were reviewed, signs and symptoms were mapped to classes in a neuro-ontology, and classes were collapsed into sixteen superclasses by subsumption. After normalization and vectorization of the data, bipartite (subject-feature) and unipartite (subject-subject) network graphs were created using NetworkX and visualized in Gephi. Degree and weighted degree were calculated for each node. Graphs were partitioned into communities using the modularity score. Feature maps visualized differences in features by community. Network …

Outcomes Of Patients Treated For Hepatoblastoma With Low Alpha-Fetoprotein And/Or Small Cell Undifferentiated Histology: A Report From The Children's Hepatic Tumors International Collaboration (Chic), Angela D Trobaugh-Lotrario, Rudolf Maibach, Daniel C Aronson, Arun Rangaswami, Beate Häberle, Allison F O'Neill, Irene Schmid, Marc Ansari, Tomoro Hishiki, Sarangarajan Ranganathan, Rita Alaggio, Ronald R De Krijger, Yukichi Tanaka, Soo-Jin Cho, Christian Vokuhl, Rebecca Maxwell, Mark Krailo, Eiso Hiyama, Piotr Czauderna, Milton Finegold, James H Feusner, Marcio H Malogolowkin, Rebecka L Meyers, Dolores Lopez-Terrada

Faculty, Staff and Students Publications

Small cell undifferentiated (SCU) histology and alpha-fetoprotein (AFP) levels below 100 ng/mL have been reported as poor prognostic factors in hepatoblastoma (HB); subsequent studies reported SMARCB1 mutations in some SCU HBs confirming the diagnosis of rhabdoid tumor. The Children's Hepatic tumors International Collaboration (CHIC) database was queried for patients with HB who had AFP levels less than 100 ng/mL at diagnosis or were historically diagnosed as SCU HBs. Seventy-three of 1605 patients in the CHIC database were originally identified as SCU HB, HB with SCU component, or HB with low AFP levels. Upon retrospective review, they were re-classified as rhabdoid …

Sgc-Camkk2-1: A Chemical Probe For Camkk2, Carrow Wells, Yi Liang, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O'Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael M Couñago, Brittany Stork, Christopher G Langendorf, Kevin Nay, Jonathan S Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R Means, Brian York, Donald P Mcdonnell, John W Scott, Daniel E Frigo, David H Drewry

Faculty, Staff and Student Publications

The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2.

Characterization Of Antiviral Immunity, Host Virus Interactions, And Toxicity Of Agrochemical Residues In The Western Honey Bee, Christopher Fellows

LSU Doctoral Dissertations

Honey bee colonies have perished at an alarming rate for over 15 years. Among the multitude of threats to bee health, virus infections and agrochemical exposure appear to be major drivers of colony loss. As virus infection is among the most damaging influences on bee health, we first investigated a putative target for antiviral immunity, termed K_ATP channels. We previously demonstrated that pharmacologically activating K_ATP channels induces the production of reactive oxygen species and increases survival during infection with Israeli Acute Paralysis Virus. Here, we demonstrate that K_ATP modulation and ROS induction reduce virus replication and enhance …

Role Of Microorganisms In Horticulture To Improve Plant Quality, Domenico Prisa

Karbala International Journal of Modern Science

One of the most anticipated challenges in the field of agriculture is to ensure high production levels while limiting the use of environmentally harmful synthetic chemicals. One of the most interesting strategies to overcome this challenge is the exploitation of the interactions between soil microorganisms and plants which result in stimulating plants’ natural activity. The interactions among mycorrhiza, growth-promoting microorganisms and plants play a crucial role in soil fertility, biocontrol and protection. The use of mixed microbial products can simulate interactions between fungi and bacteria, realising all the benefits that can be obtained from these associations in terms of quantity …

State Of The Art In Drivers’ Attention Monitoring – A Systematic Literature Review, Sama Hussein Al-Gburi, Kanar Alaa Al-Sammak, Ion Marghescu, Claudia Cristina Oprea

Karbala International Journal of Modern Science

Recently, driver inattention has become the leading cause of automobile accidents. As a result, the driver's perception and decision-making abilities are diminished, and the driver can lose control of the car. To prevent accidents caused by driver inattention, it’s vital to continuously monitor the driver and his driving behaviour and inform him if he becomes distracted or sleepy. This topic has been the subject of study for decades. Whenever feasible to recognise unsafe driving in advance, accidents could be avoided. This document presents an overview of the existing driver alertness system and the various techniques for detecting driver attentiveness.

Do Regional Dna Barcode Databases Lead To More Efficient Specimen Identification?, Michael Kerr, Steven D. Leavitt

Library/Life Sciences Undergraduate Poster Competition 2023

DNA barcoding is a method for identifying specimens from specific regions of DNA. 1 Metabarcoding focuses on large, multi specimen scales. 2 These approaches rely on DNA databases for sequence identification, 2 but these databases often lack data from many species, 3 especially from poorly studied groups such as fungi 4 and lichens, which can lead to failure in specimen identification.

On Pope Benedict, Science, Faith, And His Legacy, Bruce Ledewitz

Newspaper Columns

Collected biweekly contributions to the Pennsylvania Capital-Star, a nonpartisan, nonprofit news site.

Grounded Roots Research Synthesis: A Meta-Analysis/Meta-Synthesis Of Strategies Used By Exemplary Leaders, Robert Allen

Dissertations

Purpose: The purpose of this quantitative meta-analysis and qualitative meta-synthesis was to conduct an analysis of five thematic research studies to aggregate and integrate findings to form new interpretations of the research field of grounded leadership.

Methodology: This quantitative meta-analysis and qualitative meta-synthesis was conducted as a secondary analysis of five thematic research studies to aggregate and integrate findings to form new interpretations of the research field of grounded leadership. The sample was composed of 79 exemplary leaders from five different fields.

Findings: Examination of 79 participants found that that aggregated population of exemplary leaders maintain grounded leadership by (a) …

Leveraging Genetic Diversity In Mice To Inform Individual Differences In Brain Microstructure And Memory., Thomas J Murdy, Amy R Dunn, Surjeet Singh, Maria Telpoukhovskaia, Shanrong Zhang, Jacqueline K White, Itamar Kahn, Marcelo Febo, Catherine Kaczorowski

Faculty Research 2023

In human Alzheimer's disease (AD) patients and AD mouse models, both differential pre-disease brain features and differential disease-associated memory decline are observed, suggesting that certain neurological features may protect against AD-related cognitive decline. The combination of these features is known as brain reserve, and understanding the genetic underpinnings of brain reserve may advance AD treatment in genetically diverse human populations. One potential source of brain reserve is brain microstructure, which is genetically influenced and can be measured with diffusion MRI (dMRI). To investigate variation of dMRI metrics in pre-disease-onset, genetically diverse AD mouse models, we utilized a population of genetically …

Childhood Adversities And Risk Of Posttraumatic Stress Disorder And Major Depression Following A Motor Vehicle Collision In Adulthood, H. N. Ziobrowski, B. Holt-Gosselin, M. V. Petukhova, A. J. King, S. Lee, S. L. House, F. L. Beaudoin, X. An, J. S. Stevens, D. Zeng, T. C. Neylan, G. D. Clifford, S. D. Linnstaedt, L. T. Germine, K. A. Bollen, S. L. Rauch, J. P. Haran, A. B. Storrow, C. Lewandowski, P. I. Musey, P. L. Hendry, S. Sheikh, C. W. Jones, B. E. Punches, M. C. Kurz, R. A. Swor, L. A. Hudak, J. L. Pascual, M. J. Seamon, E. Harris, C. Pearson, R. C. Merchant

Psychology Faculty Works

Aims Childhood adversities (CAs) predict heightened risks of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) among people exposed to adult traumatic events. Identifying which CAs put individuals at greatest risk for these adverse posttraumatic neuropsychiatric sequelae (APNS) is important for targeting prevention interventions. Methods Data came from n = 999 patients ages 18-75 presenting to 29 U.S. emergency departments after a motor vehicle collision (MVC) and followed for 3 months, the amount of time traditionally used to define chronic PTSD, in the Advancing Understanding of Recovery After Trauma (AURORA) study. Six CA types were self-reported at baseline: physical …

Enhancing Sustainable Process Designs Through Strategic Material Utilization And Waste Minimization Approaches, John David Chea

Theses and Dissertations

Sustainability is a growing concern as resources are continually depleted for various applications without adequate renewal plans. The resulting impacts on the ecosystem, health, and resource circularity are often overlooked. This research analyzes improvement opportunities at each major stage in a product's life cycle. Raw material acquisition, product synthesis, process waste management, and the fate of a material in the end-of-life phases were examined. The viability of utilizing renewable resources has been demonstrated in this work by extracting bio-based chemicals from underutilized renewable resources at a commercial scale and transforming the extracted resources into polymeric materials. The optimization of raw …

Evaluation Of Precision Livestock Technology And Human Scoring Of Nursery Pigs In A Controlled Immune Challenge Experiment, Eduarda M. Bortoluzzi, Mikayla J. Goering, Sara J. Ochoa, Aaron J. Holliday, Jared M. Mumm, Catherine E. Nelson, Hui Wu, Benny E. Mote, Eric T. Psota, Ty B. Schmidt, Majid Jaberi-Douraki, Lindsey E. Hulbert

Department of Animal Science: Faculty Publications

The objectives were to determine the sensitivity, specificity, and cutoff values of a visual-based precision livestock technology (NUtrack), and determine the sensitivity and specificity of sickness score data collected with the live observation by trained human observers. At weaning, pigs (n = 192; gilts and barrows) were randomly assigned to one of twelve pens (16/pen) and treatments were randomly assigned to pens. Sham-pen pigs all received subcutaneous saline (3 mL). For LPS-pen pigs, all pigs received subcutaneous lipopolysaccharide (LPS; 300 µg/kg BW; E. coli O111:B4; in 3 mL of saline). For the last treatment, eight pigs were randomly …

Evaluation Of Precision Livestock Technology And Human Scoring Of Nursery Pigs In A Controlled Immune Challenge Experiment, Eduarda M. Bortoluzzi, Mikayla J. Goering, Sara J. Ochoa, Aaron J. Holliday, Jared M. Mumm, Catherine E. Nelson, Hui Wu, Benny Mote, Eric T. Psota, Ty B. Schmidt, Majid Jaberi-Douraki, Lindsey E. Hulbert

Department of Animal Science: Faculty Publications

The objectives were to determine the sensitivity, specificity, and cutoff values of a visual-based precision livestock technology (NUtrack), and determine the sensitivity and specificity of sickness score data collected with the live observation by trained human observers. At weaning, pigs (n = 192; gilts and barrows) were randomly assigned to one of twelve pens (16/pen) and treatments were randomly assigned to pens. Sham-pen pigs all received subcutaneous saline (3 mL). For LPS-pen pigs, all pigs received subcutaneous lipopolysaccharide (LPS; 300 μg/kg BW; E. coli O111:B4; in 3 mL of saline). For the last treatment, eight pigs were randomly …

Greywater Treatment Using Integrated Sand Filtration With Ultrafiltration For Reuse, Aya El-Wattar

Theses and Dissertations

Membrane flux was observed and the two membrane sizes that achieved stable flux were chosen to be used in the later stages of the study. The chosen membranes were of 300 kDa and 400 kDa Molecular Weight Cutoff (MWCO).

The third phase of the study involved running the full system on synthetic greywater then on real greywater. The parameters investigated were COD, TSS, Turbidity and BOD₅. Total COD removal after sand filtration, 300kDa UF and 400 kDa UF was 65, 66 and 73.4% respectively. Total TSS removal after sand filtration, 300kDa UF and 400 kDa UF was 93.1, …

Childhood Adversities And Risk Of Posttraumatic Stress Disorder And Major Depression Following A Motor Vehicle Collision In Adulthood, H N Ziobrowski, B Holt-Gosselin, M V Petukhova, A J King, S Lee, S L House, F L Beaudoin, X An, J S Stevens, D Zeng, T C Neylan, G D Clifford, S D Linnstaedt, L T Germine, K A Bollen, S L Rauch, J P Haran, A B Storrow, Christopher A. Lewandowski, P I Musey, P L Hendry, S Sheikh, C W Jones, B E Punches, M C Kurz, R A Swor, L A Hudak, J L Pascual, M J Seamon, E Harris, C Pearson, R C Merchant, R M Domeier, N K Rathlev, B J O'Neil, P Sergot, L D Sanchez, S E Bruce, M W Miller, R H Pietrzak, J Joormann, D M Barch, D A Pizzagalli, S E Harte, J M Elliott, K J Ressler, S A Mclean, K C Koenen, R C Kessler

Emergency Medicine Articles

AIMS: Childhood adversities (CAs) predict heightened risks of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) among people exposed to adult traumatic events. Identifying which CAs put individuals at greatest risk for these adverse posttraumatic neuropsychiatric sequelae (APNS) is important for targeting prevention interventions.

METHODS: Data came from n = 999 patients ages 18-75 presenting to 29 U.S. emergency departments after a motor vehicle collision (MVC) and followed for 3 months, the amount of time traditionally used to define chronic PTSD, in the Advancing Understanding of Recovery After Trauma (AURORA) study. Six CA types were self-reported at baseline: physical …

Uab Researcher Studying Ways To Reduce Toxicity In Breast Cancer Treatment, Staff

Browse All News

No abstract provided.

Sexual Dimorphism In Corallite Size And Modularity Of A Broadcast Spawning Coral, Porites Lobata, Ricardo M. Pedraza-Pohlenz, Eduardo F. Balart, J. J.Adolfo Tortolero-Langarica, Alma Paola Rodríguez-Troncoso, Michael E. Hellberg, Orión Norzagaray-López, Rafael A. Cabral-Tena, Amílcar Leví Cupul-Magaña, David A. Paz-García

Faculty Publications

Differences in selective pressures and the energetic cost of gametes in gonochoristic corals should vary with the sex of the colony, which may lead to sexual dimorphism. Coral colonies are composed of subunits (corallites) that create a complex morphological architecture. If corallite features are distinct between sexes, then the degree of coordinated change among these subunits may also vary (phenotypic modularity). This study tested for sexual dimorphism in the corallites of the reef-building coral Porites lobata, a gonochoric broadcast spawner, and compared this with previously demonstrated sexual dimorphism in its congener P. panamensis, a gonochoric brooder. Corallite area in P. …

The Trojan Horse Of The Paddy Field: Determining The Genetic Origins Of Seed Shattering In Spanish Weedy Rice, Eric Heinze

Undergraduate University Honors Capstones

Weedy rice, or red rice, is an agricultural weed that has evolved independently in different parts of the world from cultivated rice. Significant crop damage has resulted from weed infestations, leading to a loss of income for farmers and a severe reduction in crop yield. Seed shattering is one of the most distinctive and problematic characteristics of weedy rice, as it allows seeds to disperse and persist in soil for long periods and limit the effectiveness of current weed control efforts. While previous studies have identified a mutation causing a reduction in shattering between wild and cultivated rice, the exact …

Impact Of Standardized Skin-To-Skin Protocol In The Operating Room On Breastfeeding Rates, Simone M. James

Dissertations

Skin-to-skin contact (SSC) is an evidence-based practice with many benefits for mothers and their newborns. The separation of mothers from their babies after cesarean birth delays SSC, which can adversely affect the initiation and the success of breastfeeding. The purpose of this quantitative, quasi-experimental project was to determine if or to what degree the implementation of Hung and Berg's evidence-based protocol for skin-to-skin in the operating room (OR) would increase exclusive breastfeeding rates at discharge for adult women status post a cesarean delivery in a rural Arizona hospital over four-weeks. The Iowa model and Lewin's planned change theory were utilized …

Profeatx: A Parallelized Protein Feature Extraction Suite For Machine Learning, David Guevara-Barrientos, Rakesh Kaundal

Computer Science Student Research

Machine learning algorithms have been successfully applied in proteomics, genomics and transcriptomics. and have helped the biological community to answer complex questions. However, most machine learning methods require lots of data, with every data point having the same vector size. The biological sequence data, such as proteins, are amino acid sequences of variable length, which makes it essential to extract a definite number of features from all the proteins for them to be used as input into machine learning models. There are numerous methods to achieve this, but only several tools let researchers encode their proteins using multiple schemes without …

The Effect Of Naloxone Access Laws On Fatal Synthetic Opioid Overdose Fatality Rates, Mohammad Tabatabai, Robert L. Cooper, Derek M. Wilus, Ryan D. Edgerton, Aramandla Ramesh, Samuel A. Macmaster, Parul N. Patel, Karan P. Singh

School of Medicine Faculty Publications and Presentations

Background: Increases in fatal synthetic opioid overdoses over the past 8 years have left states scrambling for effective means to curtail these deaths. Many states have implemented policies and increased service capacity to address this rise. To better understand the effectiveness of policy level interventions we estimated the impact of the presence of naloxone access laws (NALs) on synthetic opioid fatalities at the state level. Methods: A multivariable longitudinal linear mixed model with a random intercept was used to determine the relationship between the presence of NALs and synthetic opioid overdose death rates, while controlling for, Good Samaritan laws, opioid …

Summer Movement Of Burbot (Lota Lota) In An Isolated Michigan River And Pre-Restoration Assessment Of The Grand River Fish Assemblage In Downtown Grand Rapids, Michigan, Usa, Alexis Neff

Masters Theses

This thesis research consisted of two complimentary projects. The first focused on understanding the ecology and life-history of an isolated population of a freshwater fish, the Burbot; the second on a pre-restoration assessment of the fish community in the Grand River.

Understanding life-history strategies of species is important to recognize changes in behavior caused by anthropogenic effects. Burbot (Lota lota), are important apex predators in their native range, is understudied, and exhibits complex life-history strategies. Specifically, little research has been done on isolated river populations. My research objective was to assess Burbot movement and habitat use over a …

Exploring The Potential Of Intranasally Administered Naturally Occurring Quercetin Loaded Into Polymeric Nanocapsules As A Novel Platform For The Treatment Of Anxiety, Shady Swidan, Khaled Younis Mahmoud, Nahla Ahmed Elhesaisy, Abdelrahman Rashed, Ebram Mikhael, Mahmoud Fadl, Mahmoud Elsadek, Merna Mohamed, Merna Mostafa, Mohamed Hassan, Omar Halema, Youssef Elnemer

Pharmacy

Anxiety is one of the most prevalent forms of psychopathology that afects millions worldwide. It gained more importance under the pandemic status that resulted in higher anxiety prevalence. Anxiolytic drugs such as benzodiazepines have an unfavorable risk/beneft ratio resulting in a shift toward active ingredients with better safety profle such as the naturally occurring quercetin (QRC). The delivery of QRC is hampered by its low water solubility and low bioavailability. The potential to enhance QRC delivery to the brain utilizing polymeric nanocapsules administered intranasally is investigated in the current study. Polymeric nanocapsules were prepared utilizing the nanoprecipitation technique. The best …