Digital Commons Network^™

Protecting New Hoosiers And Their Parents, Inga Nordgren, Robert Duncan, Kate Kester, Shelley Macdermid Wadsworth

Center for Families Publications

No abstract provided.

Evidence Of An Established Population Of Cherax Quadricarinatus (Von Martens, 1868) In South Texas, Usa, Adam Sanjar, Drew R. Davis, Richard J. Kline

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Cherax quadricarinatus (von Martens, 1868) is a large parastacid crayfish (Decapoda: Parastacidae) native to Australia and Papua New Guinea. Due to various factors, C. quadricarinatus is an emerging invasive species in an increasing number of regions across the world. Deleterious ecological effects of C. quadricarinatus introduction have been documented in many of these regions, and its spread has been monitored and restricted where possible. Previously, only a small, isolated population of C. quadricarinatus in southern California had been reported within the continental United States. Here, we report the collection of three adult C. quadricarinatus from Brownsville, Cameron County, Texas, the …

Book Review: Inhaling Spirit: Harmonialism, Orientalism, And The Western Roots Of Modern Yoga. By Anya P. Foxen., Herman Tull

Journal of Hindu-Christian Studies

No abstract provided.

Book Review: Contemplative Studies And Hinduism: Meditation, Devotion, And Prayer. Edited By Rita D. Sherma And Purushottama Bilimori, Erik Ranstrom

Journal of Hindu-Christian Studies

No abstract provided.

Extradural Primary Malignant Spinal Tumors In A Population Younger Than 25 Years: An Ambispective International Multicenter Study On Onco-Surgical Outcomes, Alexander C Disch, Stefano Boriani, Alessandro Luzzati, Laurence D Rhines, Charles G Fisher, Aron Lazary, Ziya L Gokaslan, Dean Chou, Michelle J Clarke, Michael G Fehlings, Klaus-Dieter Schaser, Nicole M Germscheid, Jeremy J Reynolds, The Ao Spine Knowledge Forum Tumor

Faculty, Staff and Student Publications

Extradural malignant primary spinal tumors are rare and outcome data, especially for younger patients, is limited. In a worldwide (11 centers) study (Predictors of Mortality and Morbidity in the Surgical Management of Primary Tumors of the Spine study; ClinicalTrials.gov Identifier NCT01643174) by the AO Spine Knowledge Forum Tumor, patients surgically treated for primary tumors of the spine between 1992 and 2012, were retrospectively analyzed from a prospective database of their medical history. Medical history, tumor characteristics, diagnostics, treatments, cross-sectional survival, and local recurrences were analyzed. Sixty-eight cases (32 f; 36 m), at an average age of 18.6 ± 4.7 years …

Patorani Local Knowledge System In Fisheries Resources Conservation Education In Galesong District South Sulawesi, Hasriyanti Hasriyanti, Rusdi Rusdi, Titus Adeyemi Alonge, Erman Syarif

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

The development of fishery resources is realized through one of the pillars of development, namely pro-environment (restoration and preservation of the environment) in the order of conservation and rehabilitation of marine resources. This study aimed to investigate and describe patorani culture, which is the local fishermen's knowledge of conserving fishery resources. This research used the qualitative descriptive method with a phenomenological approach by using several sets of data, including the preliminary studies. The data were collected through literature review, observation, and preliminary survey, and then they were analyzed based on understanding and public opinion through a qualitative approach. The informant …

The Effectiveness Of Hand Muppet Learning Media Based On Local Wisdom To Improve Cultural Literacy And Citizenship Ability, Alfi Laila, Andri Pitoyo, Sri Sukasih, Baharudin Baharudin

Journal of ICSAR

A nation with high cultural literacy describes the competence of its citizens who can think critically, creatively and communicatively in the face of global competition. The main problem of this research is the low level of cultural literacy and citizenship skills of elementary school students. One of the causes of these problems is the low quality of the learning media used in learning in elementary schools. This study aims to describe the effectiveness of using hand muppet learning media based on local wisdom and the impact of using hand muppet learning media on increasing cultural literacy skills and citizenship of …

Myelin Lipid Metabolism And Its Role In Myelination And Myelin Maintenance, Joseph A Barnes-Vélez, Fatma Betul Aksoy Yasar, Jian Hu

Faculty, Staff and Student Publications

Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high abundance of membrane lipids is one of myelin's salient features that contribute to its unique role as an insulator that electrically isolates nerve fibers across their myelinated surface. The most abundant lipids in myelin include cholesterol, glycosphingolipids, and plasmalogens, each playing critical roles in myelin development as well as function. This review serves to summarize the role of lipid metabolism in myelination and myelin maintenance, as well as the molecular determinants of myelin lipid homeostasis, with an emphasis on findings from genetic models. In addition, the implications …

Crispr, Like Any Other Technology: Shedding Determinism & Reviving Athens, Jon Khan

Canadian Journal of Law and Technology

This article examines current narratives surrounding CRISPR (clustered regularly interspaced short palindromic repeats) and the current Canadian treatment of this novel biotechnology. It argues that Canada’s current approach to genetic research and CRISPR appear to have succumbed to the false narrative of technological determinism. It argues that Canada must buck the narrative and alter the current status quo in two principal ways: Canada should pursue more somatic CRISPR clinical trials in humans and permit pre-clinical germline editing. To design a regulatory regime for clinical germline editing and better guidance on somatic CRISPR clinical trials, Canada should engage Deliberative Polling to …

An Analysis Of Cultural Values, Religiosity And Family Member's Caregiving On The Positive Appraisal Of Caring For The Elderly, Fayron R. Epps

Dissertations

The stress and burden experienced by the family caregiver during the caregiving experience has been widely researched and established among the literature. Limited research exists on the impact of cultural values, religiosity and family caregiving on the caregiver's positive appraisal of caring for a dependent elderly family member. Therefore, the purpose of this study was to examine the influence of cultural values and religiosity on the positive appraisal of caregiving among African American, Hispanic and Caucasian caregivers for dependent elderly family members. A predictive correlational study design was employed to examine the relationship amongst variables for 69 African-American, Hispanic and …

Sra Inhibition Improves Antitumor Potency Of Antigen-Targeted Chaperone Vaccine, Jie Qian, Xiaofei Yu, Zheng Liu, Jinyang Cai, Masoud H. Manjili, Hu Yang, Chunqing Guo, Xiang Yang Wang

Chemical and Biochemical Engineering Faculty Research & Creative Works

We Have Previously Demonstrated that Scavenger Receptor a (SRA) Acts as an Immunosuppressive Regulator of Dendritic Cell (DC) Function in Activating Antitumor T Cells. Here We Investigate the Potential of Inhibiting SRA Activity to Enhance DC-Targeted Chaperone Vaccines Including One that Was Recently Evaluated in Melanoma Patients. We Show that Short Hairpin RNA-Mediated SRA Silencing Significantly Enhances the Immunogenicity of DCs that Have Captured Chaperone Vaccines Designed to Target Melanoma (I.e., Hsp110-Gp100) and Breast Cancer (I.e., Hsp110-HER/Neu-ICD). SRA Downregulation Results in Heightened Activation of Antigen-Specific T Cells and Increased CD8+ T Cell-Dependent Tumor Inhibition. Additionally, Small Interfering RNA (SiRNA) Complexed …

Nanoscale Hafnium Metal-Organic Frameworks Enhance Radiotherapeutic Effects By Upregulation Of Type I Interferon And Tlr7 Expression, Eunseo Choi, Madeleine R. Landry, Nathan Pennock, Katherine Weinfurter, Multiple Additional Authors

Chemistry Faculty Publications and Presentations

Recent preclinical and clinical studies have highlighted the improved outcomes of combination radiotherapy and immunotherapy. Concurrently, the development of high-Z metallic nanoparticles as radiation dose enhancers has been explored to widen the therapeutic window of radiotherapy and potentially enhance immune activation. In this study, we evaluate folate-modified hafnium-based metal-organic frameworks (HfMOF-PEG-FA) in combination with imiquimod, a TLR7 agonist, as a well-defined interferon regulatory factor (IRF) stimulator for local antitumor immunotherapy. The enhancement of radiation dose deposition by HfMOF-PEG-FA and subsequent generation of reactive oxygen species (ROS) deregulates cell proliferation and increases apoptosis. HfMOF-PEG-FA loaded with imiquimod (HfMOF-PEG-FA@IMQ) increases DNA double-strand …

Exploration Of The Nuclear Proteomes In The Ciliate Oxytricha Trifallax, Michael W Lu, Leslie Y Beh, V Talya Yerlici, Wenwen Fang, Katarzyna Kulej, Benjamin A Garcia, Laura F Landweber

2020-Current year OA Pubs

Nuclear dimorphism is a fundamental feature of ciliated protozoa, which have separate somatic and germline genomes in two distinct organelles within a single cell. The transcriptionally active somatic genome, contained within the physically larger macronucleus, is both structurally and functionally different from the silent germline genome housed in the smaller micronucleus. This difference in genome architecture is particularly exaggerated in

Intouch Week Of January 30, 2023, New York Medical College

InTouch

• $2.725 Million in Federal Funding Helps Launch Two Programs at NYMC
• Debra Bessen, Ph.D., Receives $2.9 Million NIH Grant for Preventing Strep A Infection
• SHSP Rolls Out M.P.H. Generalist Program
• FDA Awards Supriya Jain, M.D., $1.9 million for COVID-19 Vaccine-Associated Myocarditis Research
• Augustine Moscatello, M.D., M.S., and Manoj T. Abraham, M.D., F.A.C.S, Treat Ukrainians on Mission Trip
• SHSP Launches Pharm.D./M.P.H. Program with TCOP
• Study Finds Children of Lower Socioeconomic Status Suffer Worse Outcomes After Traumatic Brain Injury

Biogeochemical And Historical Drivers Of Microbial Community Composition And Structure In Sediments From Mercer Subglacial Lake, West Antarctica, Christina Davis, Ryan A. Venturelli, Alexander B. Michaud, Jon R. Hawkings, Amanda M. Achberger, Trista J. Vick-Majors, Et Al.

Michigan Tech Publications, Part 1

Ice streams that flow into Ross Ice Shelf are underlain by water-saturated sediments, a dynamic hydrological system, and subglacial lakes that intermittently discharge water downstream across grounding zones of West Antarctic Ice Sheet (WAIS). A 2.06 m composite sediment profile was recently recovered from Mercer Subglacial Lake, a 15 m deep water cavity beneath a 1087 m thick portion of the Mercer Ice Stream. We examined microbial abundances, used 16S rRNA gene amplicon sequencing to assess community structures, and characterized extracellular polymeric substances (EPS) associated with distinct lithologic units in the sediments. Bacterial and archaeal communities in the surficial sediments …

“For The Moment, I Am Not F*Cking,” I Am Tweeting: Platforms Of / As Sexuality, Jacob Johanssen

CLCWeb: Comparative Literature and Culture

This article develops the argument that digital platforms are significantly infused with originary (and unconscious) residues of the sexual. Drawing on Laplancheian conceptualizations of sexuality, I argue that the digital has always been sexual(ised) in itself – a process that precedes and exceeds the erotic or pornographic. For Laplanche, sexuality is constitutive of the human subject as such. Infantile sexuality is shaped and transformed in an enigmatic relation with the caregiver. Drawing on this model as an analogy, I claim that users are drawn to platforms because they (unconsciously) desire to return to infantile sexuality and a holding environment but …

Amazon Web Services, The Lacanian Unconscious, And Digital Life, Marshall N. Armintor

CLCWeb: Comparative Literature and Culture

In late 2011, ex-Amazon developer Steve Yegge’s rant about his former company described Amazon’s rapid transformation from an online bookstore to a web-services entity with a ruthlessly unified platform, all guided by the idea that the company’s effort to streamline its internal efficiency could be monetized, and the resultant software products sold through Amazon Web Services. The media consumerism that fed Amazon’s early years funded a surveilling behemoth, one that everyone feared Microsoft would become. As such, AWS has become a manifestation of the internet’s Lacanian unconscious (even providing the services and hosting for Reddit), structured around the optimization of …

Purloined Significance: How Recidivism Algorithms Capture, Transform, And Automate Our Intersubjective Unconscious As Data, Macy Mcdonald

CLCWeb: Comparative Literature and Culture

Ever since ProPublica published their groundbreaking analysis of Northpointe’s Correctional Offender Management Profiling for Alternative Sanctions Core Risk and Needs Assessment software (COMPAS) in 2016, this web-based decision support system (DSS) has spawned a wide range of critiques and charges of racial bias. COMPAS provides a full suite of decision support applications to the US prison-industrial complex, including algorithmically derived recidivism predictions that increasingly guide parole decisions. The larger conversation surrounding COMPAS raises the question of how we analyze powerful, and yet opaque, data assemblages. In this article, I model an allegorical analysis of data assemblages. I argue the skills …

“There Is No Pandemic”: On Memes, Algorithms And Other Interpassive Forms Of Right-Wing Disbelief, Scott Krzych

CLCWeb: Comparative Literature and Culture

This essay examines several prominent memes that have circulated on Right-wing social media during the Covid-19 pandemic. The memes coordinate what I describe as a mode of interpassive humor, which positions those who “believe” in the crisis as naïve dupes, infantilizing those subjects who have fallen prey to the idea that they should take the pandemic seriously, and thereby delegating fearfulness to the other so that reactionary Covid-19 denialists may continue with their lives unaffected. The essay thereby seeks to draw suggestive lines of affiliation between studies of digital memes, evolutionary mimetics, and psychoanalytic theory, pointing to the algorithmic …

Stalking Oneself: The Fantasmatic Intersubjectivity Of Google, Alois Sieben

CLCWeb: Comparative Literature and Culture

This essay reads fictional and non-fictional accounts of digital stalking as signals of larger changes in intersubjectivity itself caused by Google. Most social media platforms trap users in imaginary relations, in which the other is encountered as a complete profile, but Google allows the searcher to locate an absence in the other in the form of a missing search result. As will be shown in an analysis of two contemporary novels whose first-person narrations center around Google-stalking, Caroline Kepnes’s You (2014) and Olivia Sudjic’s Sympathy (2017), Google’s mode of intersubjectivity amounts to an endless tunnel with no light at its …

Lacan And The Algorithm, Clint Burnham

CLCWeb: Comparative Literature and Culture

Exploring the development of algorithms in Lacanian theory, specifically the "R schema" in the 1950s, I argue that psychoanalysis, read through contemporary debates about the "algorithmic cult" of Netflix and other avatars of popular culture, can be said to reveal the inhuman, machinic essence of subjectivity. The etiology of algorithms, mathemes, and other formulae and diagrams in Lacan’s oeuvre has been under-studied, in part because for some readers they are not as attractive as his more bravura flourishes of word play as exegetical excess, and in part because they derive largely from the ‘hard’ structuralist moment of his work in …

Anti-Racist Considerations For Teaching Cacrep Assessment And Diagnosis Courses, Haley R. Ault, Henrietta S. Gantt, Casey A. Barrio Minton

Teaching and Supervision in Counseling

Professional counselors must act as anti-racist social justice advocates throughout the counseling relationship, including assessment, diagnosis, and treatment planning. Due to internalized racism and inappropriate instruments, assessment and diagnosis are two critical areas where marginalized populations have historically experienced misdiagnosis and pathologizing impacting overall client care and wellbeing. Inappropriate instruments, inadequate training, and counselor bias have profound impacts on access to treatment and resources for individuals holding marginalized racial identities. Although the call for anti-racist counseling is clear, the profession is still unclear on how to teach these concepts to counselor trainees. Counselor educators must be intentional about incorporating anti-racist …

Amicus Brief - Eggers V. Evnen, No. 22-2268, 8th Circuit, August 2, 2022, Anthony Schutz

Nebraska State Constitution

Because Nebraska’s constitutional provision for direct democracy involves voting and the exercise of the People’s legislative authority, it is subject to the principles of Reynolds v. Sims and the Fourteenth Amendment to the U.S. Constitution. This understanding of the People’s power of initiative and referendum as legislative is supported by Nebraska history, as is the severability of the two-fifths, county-distribution requirement from Article III, § 2 of the Nebraska Constitution. The county-distribution requirement fails the one-person-one-vote constraint placed upon States by the federal constitution. As a matter of statistical analysis, that requirement gives more power to voters in counties with …

An Analytical Study Of The Islamic Education Book For The Third Intermediate Grade In The Light Of Soft Skills. دراسة تحليلة لكتاب التربية الإسلامية للصف الثالث المتوسط في ضوء المهارات الناعمة, إبراهيم احمد الشرع, Norah Ibrahim Alanazi

Association of Arab Universities Journal for Education and Psychology

This study aimed to know the degree of inclusion of soft skills in the Islamic education book for the third intermediate graders in Saudi Arabia. A descriptive analytical approach was used. The results of the study showed that the skills of “problem solving and decision-making” and “critical and creative thinking” ranked first, and “cooperation and teamwork” skills ranked last in the book. The domain of "problem solving and decision-making" ranked first in the first part, while the domain of "critical and creative thinking" came first in the second part. In light of the results, the researchers recommend the need to …

Crow's Nest, January 29, 2023, Crow's Nest Staff

Crow's Nest

The January 29, 2023, issue of the Crow's Nest.

Malum In Se: Starvation Crimes In International Law, Laura K. Graham

The International Journal of Ethical Leadership Special Volumes

No abstract provided.

Impacts Of Dietary Lysine And Crude Protein On Performance, Hepatic And Renal Functions, Biochemical Parameters, And Histomorphology Of Small Intestine, Liver, And Kidney In Broiler Chickens, Mohamed A Mousa, Ahamed S Asman, Reham M J Ali, Ramy K A Sayed, Kamlah A Majrashi, Khloud G Fakiha, Rashed A Alhotan, Shaimaa Selim

Faculty, Staff and Student Publications

The present study aimed to investigate the effects of increasing dietary lysine (Lys) levels with an adequate dietary crude protein (CP) content, as well as the effects of a reduction in dietary CP content with the recommended amino acid (AAs) level, on the performance, blood biochemical parameters, and histomorphology of the duodenum, liver, and kidney in broiler chickens. A total of 500 broiler chickens were randomly distributed into five dietary treatment groups, following a completely randomized design, where, at the beginning, the control group (C) was fed a diet containing the standard CP and Lys levels: 23% CP with 1.44% …

Effects Of Alginate Oligosaccharide On Testosterone-Induced Benign Prostatic Hyperplasia In Orchiectomized Rats, You-Jee Jang, Hye-Yeon Jung, Ju-Yeong Myeong, Kwang Hoon Song, Joseph Kwon, Duwoon Kim, Jae-Il Park

Faculty, Staff and Student Publications

Benign prostatic hyperplasia (BPH) is an age-related disease of the urinary system that affects elderly men. Current treatments for BPH are associated with several adverse effects, thus highlighting the need for alternative agents. Alginate oligosaccharide (AOS), a water-soluble functional oligomer derived from brown algae, inhibits prostate cancer cell proliferation. However, the effects of AOS on BPH and the underlying molecular mechanisms remain unclear. Therefore, here, we aimed to investigate the therapeutic potential of AOS in BPH by using human benign prostatic epithelial cells (BPH-1) and a rat model of testosterone-induced BPH. Treatment with AOS inhibited in vitro and in vivo …

The Known And Unknowns Of Aphid Biotypes, And Their Role In Mediating Host Plant Defenses, Neetu Khanal, Christopher Vitek, Rupesh R. Kariyat

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Insect species are subjected to disparate selection pressure due to various biotic and abiotic stresses. Management practices including the heavy use of chemical insecticides and introduction of insect-resistant plant cultivars have been found to accelerate these processes. Clearly, natural selection coupled with human intervention have led to insect adaptations that alter phenotypes and genetic structure over time, producing distinct individuals with specialized traits, within the populations, commonly defined as biotypes. Biotypes are commonly found to have better fitness in the new environment and, in the case of aphids, the most commonly studied system for biotypes, have the ability to successfully …

Exploring The Past, Present, And Future Of Anti-Angiogenic Therapy In Glioblastoma., Ashley B. Zhang, Khashayar Mozaffari, Brian Aguirre, Victor Li, Rohan Kubba, Nilay C Desai, Darren Wei, Isaac Yang, Madhuri Wadehra

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Glioblastoma, a WHO grade IV astrocytoma, constitutes approximately half of malignant tumors of the central nervous system. Despite technological advancements and aggressive multimodal treatment, prognosis remains dismal. The highly vascularized nature of glioblastoma enables the tumor cells to grow and invade the surrounding tissue, and vascular endothelial growth factor-A (VEGF-A) is a critical mediator of this process. Therefore, over the past decade, angiogenesis, and more specifically, the VEGF signaling pathway, has emerged as a therapeutic target for glioblastoma therapy. This led to the FDA approval of bevacizumab, a monoclonal antibody designed against VEGF-A, for treatment of recurrent glioblastoma. Despite the …