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Articles 1711 - 1740 of 35220
Full-Text Articles in Entire DC Network
Identification Of Candidate Dna Methylation Biomarkers Related To Alzheimer’S Disease Risk By Integrating Genome And Blood Methylome Data, Yanfa Sun, Jingjing Zhu, Yaohua Yang, Zichen Zhang, Hua Zhong, Guanghua Zeng, Dan Zhou, Richard S Nowakowski, Jirong Long, Chong Wu, Lang Wu
Identification Of Candidate Dna Methylation Biomarkers Related To Alzheimer’S Disease Risk By Integrating Genome And Blood Methylome Data, Yanfa Sun, Jingjing Zhu, Yaohua Yang, Zichen Zhang, Hua Zhong, Guanghua Zeng, Dan Zhou, Richard S Nowakowski, Jirong Long, Chong Wu, Lang Wu
Faculty, Staff and Student Publications
Alzheimer disease (AD) is a common neurodegenerative disease with a late onset. It is critical to identify novel blood-based DNA methylation biomarkers to better understand the extent of the molecular pathways affected in AD. Two sets of blood DNA methylation genetic prediction models developed using different reference panels and modelling strategies were leveraged to evaluate associations of genetically predicted DNA methylation levels with AD risk in 111,326 (46,828 proxy) cases and 677,663 controls. A total of 1,168 cytosine-phosphate-guanine (CpG) sites showed a significant association with AD risk at a false discovery rate (FDR) < 0.05. Methylation levels of 196 CpG sites were correlated with expression levels of 130 adjacent genes in blood. Overall, 52 CpG sites of 32 genes showed consistent association directions for the methylation-gene expression-AD risk, including nine genes (CNIH4, THUMPD3, SERPINB9, MTUS1, CISD1, FRAT2, CCDC88B, FES, and SSH2) firstly reported as AD risk genes. Nine of 32 genes were enriched in dementia and AD disease categories (P values ranged from 1.85 × 10-4 to 7.46 × 10-6), and 19 genes in a neurological disease network (score = 54) were also observed. Our findings improve the understanding of genetics and etiology for AD.
Our Weird Living World, Saugat Bolakhe
Our Weird Living World, Saugat Bolakhe
Capstones
The series of articles featured in this portfolio dives into the weirdest and most unique natural phenomena that power and sustain our living world. It features the eccentric worlds of microbes that have a chemical trick for making oxygen that could sustain entire underground ecosystems, birds that go on to choosing vocal coaches based on sounds they hear as embryos, moths that keep on blinding children in Nepal, algae and their cost of adapting in warming oceans and female insects that hide cryptic sex for their survival.
Link: https://saugatbol.wixsite.com/saugat-bolakhe
Connecting With A Lost Heritage: The Indigenous Taino Community Of The Caribbean In New York City, Angeles R. Rodriguez Negron
Connecting With A Lost Heritage: The Indigenous Taino Community Of The Caribbean In New York City, Angeles R. Rodriguez Negron
Capstones
Among New York City's diasporic communities lie the Indigenous Tainos, an aboriginal people originally from the Caribbean region. But many people are unaware of their existence. There is a belief among Puerto Ricans and other Caribbean societies that the Tainos are an extinct tribe since the 16th century due to European colonization. The Taino revivalist movement has taken strength during the last 30 years, and more Taino descendants are taking pride on their identity and culture. After 5 months of collaboration with this Indigenous community, Puerto Rican journalist Ángeles Rodríguez Negrón created Miyari Taino, a podcast designed to provide visibility …
Decreased Fxr Agonism In The Bile Acid Pool Is Associated With Impaired Fxr Signaling In A Pig Model Of Pediatric Nafld, Magdalena A Maj, Douglas G Burrin, Rodrigo Manjarín
Decreased Fxr Agonism In The Bile Acid Pool Is Associated With Impaired Fxr Signaling In A Pig Model Of Pediatric Nafld, Magdalena A Maj, Douglas G Burrin, Rodrigo Manjarín
Faculty, Staff and Students Publications
The objective of this study was to investigate whether the impairment of farnesoid X receptor (FXR)-fibroblast growth factor 19 (FGF19) signaling in juvenile pigs with non-alcoholic fatty liver disease (NAFLD) is associated with changes in the composition of the enterohepatic bile acid pool. Eighteen 15-day-old Iberian pigs, pair-housed in pens, were allocated to receive either a control (CON) or high-fructose, high-fat (HFF) diet. Animals were euthanized in week 10, and liver, blood, and distal ileum (DI) samples were collected. HFF-fed pigs developed NAFLD and had decreased FGF19 expression in the DI and lower FGF19 levels in the blood. Compared with …
Probing And Enhancing The Reliance Of Transformer Models On Poetic Information, Almas Abdibayev
Probing And Enhancing The Reliance Of Transformer Models On Poetic Information, Almas Abdibayev
Dartmouth College Ph.D Dissertations
Transformer models have achieved remarkable success in the widest variety of domains, spanning not just a multitude of tasks within natural language processing, but also those in computer vision, speech, and reinforcement learning. The key to this success is largely attributed to the self-attention mechanism, particularly its ability to scale in performance as it grows in the number of parameters. Extensive effort has been underway to study the major linguistic properties learned by these models during the course of their pretraining. However, the role of certain finer linguistic phenomena present in language and their utilization by Transformers has not been …
Abortion In The Fiction Of Laclos, Rousseau, Isabelle De Charrière, Montesquieu, Servanne Woodward
Abortion In The Fiction Of Laclos, Rousseau, Isabelle De Charrière, Montesquieu, Servanne Woodward
ABO: Interactive Journal for Women in the Arts, 1640–1830
Eighteenth-century French fiction containing episodes on abortion are influenced by the seventeenth-century scandal of La Voisin, and by the 1731 legal suit involving the Jesuit Priest Père Girard and Catherine Cadière. Two observations may be derived from eighteenth-century French novels: women's abortions are monitored, instigated, and decided by fathers, husbands and lovers, who select for them, if they are to remain celibate, and whose children they bear. And as well, abortion tests or reveals the limits of a woman’s individual freedom and right to care for herself.
The Quick And The Dead (And The Transported), Manushag N. Powell
The Quick And The Dead (And The Transported), Manushag N. Powell
ABO: Interactive Journal for Women in the Arts, 1640–1830
In most nations that still execute prisoners—including the U.S.—it is illegal to execute a pregnant person. In English common law, women have been permitted to “plead the belly” in one form or another since the 14th century, and this fact is sometimes misconstrued by anti-choice and forced-birth advocates as evidence of a long legal tradition of protection for the lives of fetuses. In fact, it is merely evidence of a long history of legal inconsistencies in the ways laws were applied and sentences carried out against women, for whom there were fewer options for clemency than for men. This …
Review Of Reckoning With Slavery, By Jennifer L. Morgan, Brigitte Fielder
Review Of Reckoning With Slavery, By Jennifer L. Morgan, Brigitte Fielder
ABO: Interactive Journal for Women in the Arts, 1640–1830
Review of Reckoning with Slavery, by Jennifer L. Morgan,
Index To Volume 34, 2006, Bird Observer
Everything But The Beak, John Kricher
Seabirds As Indicators Of Environmental Health: Citizen Scientists Monitor Seabird Mortality Throughout The Northeast Usa, Julie C. Ellis, Mark Pokras, Florina Tseng
Seabirds As Indicators Of Environmental Health: Citizen Scientists Monitor Seabird Mortality Throughout The Northeast Usa, Julie C. Ellis, Mark Pokras, Florina Tseng
Bird Observer
No abstract provided.
Adventures Of The Rowley Dump Girls (And Boys), Mary Cunningham
Adventures Of The Rowley Dump Girls (And Boys), Mary Cunningham
Bird Observer
No abstract provided.
Birding Milford Point, Connecticut, Nick Bonomo
The Urban Ecology Institute Teaches Local Youth About The Birds Of Boston, Annie Cardinaux, Andrew Breck
The Urban Ecology Institute Teaches Local Youth About The Birds Of Boston, Annie Cardinaux, Andrew Breck
Bird Observer
No abstract provided.
The Arnold Arboretum: A Century Of Birders And Breeding Bird Data, Robert Mayer
The Arnold Arboretum: A Century Of Birders And Breeding Bird Data, Robert Mayer
Bird Observer
No abstract provided.
About Books: Summer Isles Of Eden, Mark Lynch
Massachusetts Important Bird Areas (Ibas) – The Greater Boston Region, Wayne Petersen, Brooke Stevens
Massachusetts Important Bird Areas (Ibas) – The Greater Boston Region, Wayne Petersen, Brooke Stevens
Bird Observer
No abstract provided.
Recovery And Biology Of The Common Raven (Corvus Corax) In Massachusetts, Tom French
Recovery And Biology Of The Common Raven (Corvus Corax) In Massachusetts, Tom French
Bird Observer
No abstract provided.
Glass: A Deadly Conservation Issue For Birds, Daniel Klem Jr.
Glass: A Deadly Conservation Issue For Birds, Daniel Klem Jr.
Bird Observer
No abstract provided.
Field Note: Latest Occurrence Of Arctic Tern For Massachusetts, Richard R. Veit, Carolyn S. Mostello
Field Note: Latest Occurrence Of Arctic Tern For Massachusetts, Richard R. Veit, Carolyn S. Mostello
Bird Observer
No abstract provided.
A Summer At Monomoy, Ryan Merrill
About Books: Tools, Mark Lynch
Driving Birds Away, Christopher Reed
Yellow-Nosed Albatross At Tuckernuck Island, Massachusetts, Richard R. Veit
Yellow-Nosed Albatross At Tuckernuck Island, Massachusetts, Richard R. Veit
Bird Observer
No abstract provided.
White Memorial Foundation: Litchfield And Morris, Connecticut, Buzz Devine, Dwight G. Smith
White Memorial Foundation: Litchfield And Morris, Connecticut, Buzz Devine, Dwight G. Smith
Bird Observer
No abstract provided.
About The Cover: Solitary Sandpiper, William E. Davis Jr.
About The Cover: Solitary Sandpiper, William E. Davis Jr.
Bird Observer
No abstract provided.
First Record Of Clark's Grebe In Maine And New England, Peter D. Vickery, Derek J. Lovitch
First Record Of Clark's Grebe In Maine And New England, Peter D. Vickery, Derek J. Lovitch
Bird Observer
No abstract provided.
The Underpinnings Of Breeding Behaviors, Brandi Van Roo
The Underpinnings Of Breeding Behaviors, Brandi Van Roo
Bird Observer
No abstract provided.
The "Wellesley Boys" - Contributions To Continental Birding, David B. Freeland
The "Wellesley Boys" - Contributions To Continental Birding, David B. Freeland
Bird Observer
No abstract provided.
About Books: The Hills Are Alive With The Sound Of Thrashers, Titmice, And Robbins I.E., Music, Mark Lynch
About Books: The Hills Are Alive With The Sound Of Thrashers, Titmice, And Robbins I.E., Music, Mark Lynch
Bird Observer
No abstract provided.