Digital Commons Network^™

Sharp Stick Grasps At Autistic Women’S Liminal Vulnerability, Meaghan Krazinski

Ought: The Journal of Autistic Culture

This film analysis of Sharp Stick by Lena Dunham critically explores how the film uptakes representations of the ideas around the vulnerabilities of Autistic women in popular culture, and yet does not explicitly name them as such. This liminality is critical and plays into the intersectional analysis that the author engages around the way vulnerability and Autistic identity is interpreted and read. The author draws upon McDermott's (2022) "neurotypical gaze" in an analysis that shows how traditional tropes around Autistic women’s vulnerability are social constructions that are brought into relief by stereotypes around race, gender, and ability. The author uses …

Critical Autism Studies Beyond Academia: An Annotated List, Alyssa Hillary Zisk

Ought: The Journal of Autistic Culture

This is an introduced and annotated list of sources from beyond academia which are, have been, or may yet be important texts for critical autism or neurodiversity studies. The defining actions of critical autism studies, or of critical neurodiversity studies, have been taken outside academia and will continue to be taken outside academia. This list serves as a reminder of this reality through examples.

The Minutes Of The Marshall University Board Of Governors Meeting, December 13, 2023, Marshall University Board Of Governors

Board of Governors Minutes

No abstract provided.

Mastery Learning: Second Chances, Instructor Workload, And Student Confidence, Judith Puncochar

Conference Presentations

No abstract provided.

Genomic Analysis Reveals New Species And Subspecies Of Butterflies, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

Large-scale genomic sequencing of butterfly taxa reveals new findings that are presented here. While we focus on detecting species by comparative genomics and define subspecies as groups of populations genetically differentiated from each other but not as strongly as species (that is, subspecies as species in the making), we report other adjustments to butterfly classification. As a result, 4 subgenera, 11 species, and 6 subspecies are proposed as new. New subgenera are: Rapis Grishin, subgen. n. (type species Papilio rapae Linnaeus, 1758, genus Pieris Schrank, 1801) in Pieridae Swainson, 1820 and Callitera Grishin, subgen. n. (type species Eurygona? pulcherrima …

A Pilot Study In Healthcare: Salivary Cortisol Levels And Burnout, Hannah Oggerino

Graduate Theses & Non-Theses

This pilot study investigated levels of burnout in non-clinical workers in a healthcare setting and compared them to salivary cortisol concentrations. Mashlach’s Burnout Inventory-Human Service Survey for Medical Personnel (MBI-HSS(MP)) was used to evaluate self-perceived levels of burnout and saliva samples were collected to determine cortisol concentrations at four times during participants’ shift. The study was comprised of subjects exposed to multiple high-stress factors, including working in a healthcare setting, post-COVID ramifications, and demographic effects of Montana. The data revealed a statistically significant correlation (P-value < 0.05) between morning salivary cortisol secretion concentrations and mean survey scores. Significance (P-value < 0.05) was also found between the three dimensions measured by the MBI-HSS(MP): burnout, depersonalization, and personal achievement. The study discusses several limitations that should be considered when interpreting results. Findings do suggest that future investigation among this group is needed. Results may help guide interventions that support the mental health and wellbeing of medical support personnel, reduce stress, and avoid burnout.

Unleashing The Beast: Confronting Animal Trafficking As Organized Crime In The Americas, Erick J. Wilson

University of Miami Inter-American Law Review

Wildlife trafficking is a serious yet often overlooked issue across the Americas. This Note examines wildlife trafficking across the Americas, analyzing the legal frameworks and challenges facing countries like the United States, Guatemala, Argentina, Peru, Mexico, and Brazil. Three key obstacles emerge: the lack of recognition of trafficking as organized crime, limited resources for enforcement, and deficient penalties. Though the United States has laws like the Lacey Act to address importation of illegally traded wildlife, weak foreign laws constrain efficacy. Many Latin American nations do not categorize wildlife trafficking as organized crime, despite its intricate parallels with activities like drug …

2023 December 13 - Undergraduate Curriculum Council Minutes, Undergraduate Curriculum Council, East Tennessee State University

Undergraduate Curriculum Council Minutes

No abstract provided.

Memory Cd8 T Cells Promote Pathogenic Plaque Buildup Of The Arteries In Aged Mice, Jeff Hansen

Browse All News

No abstract provided.

Role Of Gonadotropin-Releasing Hormone 2 And Its Receptor In Human Reproductive Cancers, Dr. Amy T. Desaulniers, Brett White

School of Veterinary and Biomedical Sciences: Faculty Publications

Gonadotropin-releasing hormone (GnRH1) and its receptor (GnRHR1) drive reproduction by regulating gonadotropins. Another form, GnRH2, and its receptor (GnRHR2), also exist in mammals. In humans, GnRH2 and GnRHR2 genes are present, but coding errors in the GnRHR2 gene are predicted to hinder full-length protein production. Nonetheless, mounting evidence supports the presence of a functional GnRHR2 in humans. GnRH2 and its receptor have been identified throughout the body, including peripheral reproductive tissues like the ovary, uterus, breast, and prostate. In addition, GnRH2 and its receptor have been detected in a wide number of reproductive cancer cells in humans. Notably, GnRH2 analogues …

Développement De Méthodes Analytiques Pour Les Composés Organiques Volatils Microbiens (Covm) Dans Les Matrices Biologiques : Vers L’Évaluation Des Covm Comme Biomarqueurs D’Exposition Aux Moisissures, Badr El Aroussi, Sarah Tabbal, Wissam Berkane, Michèle Bouchard, Geneviève Marchand, Sami Haddad

Rapports de recherche scientifique

Préalablement, vingt composés organiques volatils microbiens (COVM), avec un potentiel d’être utilisés comme biomarqueurs de contamination et d’exposition aux moisissures en milieu de travail, avaient été identifiés, en considérant plusieurs paramètres, comprenant l’intérêt pour la santé des espèces de moisissures, l’occurrence d’émission ainsi que les paramètres physicochimiques et pharmacocinétiques.

Dans la présente étude, de nouvelles méthodes analytiques, pour mesurer simultanément 21 COVM incluant ceux identifiés préalablement dans les matrices biologiques et l’air ambiant, en se basant sur les techniques H-SPME-GC-MS/MS (sang et urine) et TD-GCMS/MS (exhalât et air ambiant), ont été développées et validés. Celles-ci ont exhibé des performances analytiques …

The Impact Of Sea-Level Rise On Coastal Wetlands Using In-Situ Mesocosm Experiments, Landscape Modeling, And Traditional Ecological Knowledge Mapping, Kelly San Antonio

Master's Theses

Sea-level rise is an escalating threat to coastal wetlands as increased inundation and saltwater intrusion can lead to lowered productivity, decreased biomass, and plant death – and ultimately land loss. In chapter one, I detailed the interactive effects of inundation and nitrogen on two commonly found saltmarsh species, Spartina alterniflora and Spartina patens. I examined productivity and metrics to these stressors using a controlled mesocosm experiment in the western channel of the Pascagoula River, Mississippi. I found varying strategies of growth between species and differing responses between the short- and long-term. Overall Spartina alterniflora performed better with increased inundation …

Moving On: An Overview Of Approaching Trauma Through Dance/Movement Therapy, Eliza Barber

Student Works

Dance/Movement Therapy (DMT), an approach meant to facilitate holistic integration, has been historically associated with treating symptoms of trauma. Because it is a relatively new field, many questions still remain regarding appropriate interventions. In this extensive review of existing literature on the topic, I explored how DMT is applied in relation to Post-Traumatic Stress Disorder, culture-specific trauma and oppression, multigenerational trauma, and developmental trauma. Additionally, I delved into interventions with specific populations including refugees and young people. To identify the 26 items of literature referenced in this review, I conducted searches with appropriate terms on two scientific databases and filtered …

Sustained Beneficial Infections: Priority Effects, Competition, And Specialization Drive Patterns Of Association In Intracellular Mutualisms, Malcolm Hill, Barry Lawson, John W. Cain, Nasheya Rahman, Shiv Toolsidass, Tongyu Wang, Sara Geraghty, Eberardo Raymundo, April Hill

All Faculty Scholarship

Intracellular symbioses provide a useful system for exploring evolutionary and ecological forces that shape mutualistic partnerships. Within- and among-host competitiveness driven by different strategies that symbionts adopt as they transfer materials to the host across a sub-cellular membrane might explain patterns of host:symbiont association observed in natural systems. We tested the hypothesis that different translocation strategies employed by symbionts affect their ability to occupy host habitats using two distinct modeling approaches. The first involved constructing a deterministic, Lotka-Volterra-type model with two symbiont species competing for access to a single host. The model recovered expected behaviors of co-occupancy/coinfection as well as …

Designing Secondary Level Physics Course’S Instruction Over Lms, Jimita Pokharel

Instructional Psychology and Technology Graduate Student Projects

This project aimed to revamp the science course delivery at a private school in the Tanahun district of Nepal, with a primary focus on transitioning from conventional in-person instruction to a blended learning model. The specific target was the 10th-grade physics curriculum, encompassing Units 1–4. The existing teaching methodology relied on paper-based materials and face-to-face lectures, lacking any online teaching or learning components. This transformation sought to address this gap, recognizing the increasing significance of online education in adapting to unforeseen challenges such as the COVID-19 pandemic and aligning with the advancements in the global educational landscape.

Effect Of Timing Of Energy Intake On Blood Glucose And Body Composition In Women With Overweight Or Class One Obesity, Michael Wade Smith

Theses and Dissertations

Overweight and obesity has increased in the U.S. Unfortunately, this increases the risk of metabolic dysfunction, such as diabetes. Meal timing has recently shown promise as viable options to minimize the risk of overweight or obesity and metabolic dysfunction. The primary purpose of this study, therefore, was to investigate the effect of timing of energy intake on blood glucose in females with overweight or class one obesity (BMI=27-35 kg/m2). This study utilized crossover design with two conditions counterbalanced in random order. Participants completed two 2-week 1500kcal dietary interventions: 1) a big breakfast diet or BB (50% of energy intake between …

Towards An Efficient Machine Learning Based Phish Detection System, Hamad Alfalasi

Theses

Over the recent past, the world has experienced a digital revolution that has profoundly transformed many aspects of human life. This revolution has redefined the way individuals interact, how businesses operate, and how societies function. For businesses, operations have been fundamentally altered, changing the way they interact with customers and other businesses through digital tools and platforms used for transactions. Phishing, a deceitful approach, leverages technological and social tricks to access sensitive personal information, including financial details. A common attack mode involves installing harmful software on electronic devices to gain unauthorized access to personal information, particularly usernames and passwords of …

Sticks, Naomi Karen Miller

Theses

Sticks is a thesis consisting of allegorical sculptural objects informed by chairs and inspired by a transgender woman’s personal narrative. Derived from personal anecdotes and feelings, the objects form a constellation of moments in time. The body of work primarily consists of burned wooden chairs. The chairs are analogous to the self. Fire is applied to the chair to document change. My work is about the ways an individual is changed by small moments of interaction. It explores the relationship between identity, observation, perception, and time.

Celestial Bodies, Rebecca L. Rand, Mark Popinchalk

Capstones

Most of us will never come close to touching space. But space touches us every day. On Celestial Bodies, journalist Rebecca Rand and astronomer Mark Popinchalk explore the ways outer space interacts with life on earth.

In Episode 1, hosts Rebecca Rand and Mark Popinchalk explore how, for millions of years, trees have been recording celestial events in space. Within the rings of their trunks, trees store radiation from solar flares, supernovae, and changes in the earth’s magnetic field. The hosts talk to Dr. Ben Pope to learn more about what we can discover by looking at radioactive molecules …

Minutes From December 13 2023, University Senate

University Senate Minutes

Minutes from December 13 2023 University Senate Meeting

Nutrient And Microbiome-Mediated Plant–Soil Feedback In Domesticated And Wild Andropogoneae: Implications For Agroecosystems, Amanda Quattrone, Yuguo Yang, Pooja Yadav, Karrie A. Weber, Sabrina E. Russo

School of Biological Sciences: Faculty Publications

Plants influence the abiotic and biotic environment of the rhizosphere, affecting plant performance through plant–soil feedback (PSF). We compared the strength of nutrient and microbemediated PSF and its implications for plant performance in domesticated and wild grasses with a fully crossed greenhouse PSF experiment using four inbred maize genotypes (Zea mays ssp. mays b58, B73- wt, B73-rth3, and HP301), teosinte (Z. mays ssp. parviglumis), and two wild prairie grasses (Andropogon gerardii and Tripsacum dactyloides) to condition soils for three feedback species (maize B73-wt, teosinte, Andropogon gerardii). We found evidence of negative …

Mutational Analysis Of The Nitrogenase Carbon Monoxide Protective Protein Cown Reveals That A Conserved C‑Terminal Glutamic Acid Residue Is Necessary For Its Activity, Dustin L. Willard, Joshuah J. Arellano, Mitch Underdahl, Terrence M. Lee, Avinash S. Ramaswamy, Gabriella Fumes, Agatha Kliman, Emily Y. Wong, Cedric P. Owens

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Nitrogenase is the only enzyme that catalyzes the reduction of nitrogen gas into ammonia. Nitrogenase is tightly inhibited by the environmental gas carbon monoxide (CO). Many nitrogen fixing bacteria protect nitrogenase from CO inhibition using the protective protein CowN. This work demonstrates that a conserved glutamic acid residue near the C-terminus of Gluconacetobacter diazotrophicus CowN is necessary for its function. Mutation of the glutamic acid residue abolishes both CowN’s protection against CO inhibition and the ability of CowN to bind to nitrogenase. In contrast, a conserved C-terminal cysteine residue is not important for CO protection by CowN. Overall, this work …

Policy Review And Recommendation For Secondary Education Np-Led Clinics In The Southeastern United States, Shiney Alex Jacob

Student Scholarly Projects

Secondary-level education involves adolescent children aged 11-12 years to 18-19 with unique healthcare needs. Their healthcare is of significant importance as they are transitioning to adulthood, and a majority of them lack access to primary healthcare needs. Advanced Practice Registered Nurses/Nurse Practitioners (APRNs/NPs) provide high-quality, cost-effective, and evidence-based care to people across the lifespan, and there is minimal utilization of their services in meeting the primary care needs of adolescents at the secondary school level. The purpose of the policy project was to determine if current policies and practices related to school health services in three southeastern states of the …

Behavioural Responses Of Fin Whales To Military Mid-Frequency Active Sonar, Brandon L. Southall, Ann N. Allen, John Calambokidis, Caroline Casey, Stacy L. Deruiter, Selene Fregosi, Ari S. Friedlaender, Jeremy A. Goldbogen, Catriona M. Harris, Elliott L. Hazen, Valentin Popov, Alison K. Stimpert

Faculty Research, Scholarly, and Creative Activity

The effect of active sonars on marine mammal behaviour is a topic of considerable interest and scientific investigation. Some whales, including the largest species (blue whales, Balaenoptera musculus), can be impacted by mid-frequency (1-10 kHz) military sonars. Here we apply complementary experimental methods to provide the first experimentally controlled measurements of behavioural responses to military sonar and similar stimuli for a related endangered species, fin whales (Balaenoptera physalus). Analytical methods include: (i) principal component analysis paired with generalized additive mixed models; (ii) hidden Markov models; and (iii) structured expert elicitation using response severity metrics. These approaches provide complementary perspectives on …

Cannabis-Induced Psychotic Disorder And Schizophrenia Diagnostic Comparison, Tyanna Brodhagen

Honors Theses

Recent changes in cannabis legalization will have broad societal impacts for decades to come, not the least of which are the unknown consequences to neuropsychiatric health, particularly for adolescents and young adults. Cannabis-induced psychotic disorder (CIPD) is a controversial and poorly understood neuropsychiatric condition characterized by a psychotic experience brought on by excessive cannabis intoxication and/or withdrawal. Although CIPD is currently an uncommon diagnosis, the overlapping symptomology and comorbidity with schizophrenia indicates CIPD may be underdiagnosed. Some authors suggest the under diagnosis of CIPD may be correlated to physician diagnostic practices. This honors thesis constitutes a scholarly literature review and …

In The Words Of Early Adolescents: A Novel Assessment Of Positive Psychological Well-Being Predicts Young Adult Depressive Symptoms, Julia K. Boehm, Farah Qureshi, Laura D. Kubzansky

Psychology Faculty Articles and Research

Purpose

Methods

The Emotional Experience Of Representative Bureaucrats In A Contested Public Policy Environment, Shaun Damien Heckstall

Walden Dissertations and Doctoral Studies

No abstract provided.

Epigenomic Mapping Reveals Distinct B Cell Acute Lymphoblastic Leukemia Chromatin Architectures And Regulators, Kelly R Barnett, Robert J Mobley, Jonathan D Diedrich, Brennan P Bergeron, Kashi Raj Bhattarai, Alexander C Monovich, Shilpa Narina, Wenjian Yang, Kristine R Crews, Christopher S Manring, Elias Jabbour, Elisabeth Paietta, Mark R Litzow, Steven M Kornblau, Wendy Stock, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Charles G Mullighan, Mary V Relling, Shondra M Pruett-Miller, Russell J H Ryan, Jun J Yang, William E Evans, Daniel Savic

Faculty, Staff and Student Publications

B cell lineage acute lymphoblastic leukemia (B-ALL) is composed of diverse molecular subtypes, and while transcriptional and DNA methylation profiling has been extensively examined, the chromatin landscape is not well characterized for many subtypes. We therefore mapped chromatin accessibility using ATAC-seq in primary B-ALL cells from 156 patients spanning ten molecular subtypes and present this dataset as a resource. Differential chromatin accessibility and transcription factor (TF) footprint profiling were employed and identified B-ALL cell of origin, TF-target gene interactions enriched in B-ALL, and key TFs associated with accessible chromatin sites preferentially active in B-ALL. We further identified over 20% of …

Monitoring Glucocorticoid Receptor In Plasma-Derived Extracellular Vesicles As A Marker Of Resistance To Androgen Receptor Signaling Inhibition In Prostate Cancer, Emanuela Gentile, Andrew W Hahn, Jian H Song, Anh Hoang, Peter D A Shepherd, Sumankalai Ramachandran, Nora M Navone, Eleni Efstathiou, Mark Titus, Paul G Corn, Sue-Hwa Lin, Christopher J Logothetis, Theocharis Panaretakis

Faculty, Staff and Student Publications

Disease progression following androgen ablation was shown to be associated with upregulation of the glucocorticoid receptor (GR). Longitudinal monitoring of GR expression in circulating extracellular vesicles (EV) may reflect changes in the tumor cell and facilitates detection of acquired resistance. We utilized LNCaP, LREX cells and a patient-derived xenograft, MDA PDX 322-2-6a, for in vitro and in vivo experiments. Plasma-derived EVs were isolated from patients with localized high-risk prostate cancer undergoing androgen ablation. The mRNA levels of GR in EVs and their responsive genes were detected by transcriptome analysis, qRT-PCR and the protein levels by Western blot analysis. We detected …

Single-Nuclei Resolution Kidney Profiling In Physiological And Disease Settings, Ruiyang Liu

Arts & Sciences Graduate Student Theses and Dissertations

The kidney is a critical organ responsible for the maintenance of fluid, electrolyte and metabolites in the body. Recent advancements in kidney research, including the use of single-nuclei RNA Sequencing (snRNA-Seq), have uncovered a complex landscape that encompasses both physiological and pathological conditions. The scope of my thesis covers two important aspects: (1) the exploration of kidney sexual dimorphism, (2) a detailed investigation of polycystic kidney disease (PKD). To obtain a comprehensive understanding of the molecular regulation of kidney sexual dimorphism, we integrated single nucleus RNA and ATAC sequencing (snRNA-Seq and snATAC-Seq) and Visium spatial transcriptomics (ST) data to build …