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2023

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Examining The Predictive Relationship Between Map Reading Scores And Instructional Setting Among Students With Disabilities, Erika Renee' Simpson Jul 2023

Examining The Predictive Relationship Between Map Reading Scores And Instructional Setting Among Students With Disabilities, Erika Renee' Simpson

Doctoral Dissertations and Projects

The purpose of this quantitative, correlational study was to examine if the English instructional setting and special education disability predict the reading achievement of middle school students with disabilities. The findings of this study are useful in determining the effectiveness of inclusion in the English general education classroom for students with specific learning disability (SLD), attention-deficit hyperactivity disorder (ADHD), and speech and language impairment (SLI). The 116 participants of this study are middle school students enrolled in a public middle school in Georgia. All participants received special education services through the implementation of an Individual Education Plan (IEP). Archival data …


New Media To Promote Jambi People's Struggle Museum Based On Digital Marketing, M Rian Indra Eftritianto Jul 2023

New Media To Promote Jambi People's Struggle Museum Based On Digital Marketing, M Rian Indra Eftritianto

International Review of Humanities Studies

A museum is a place to record world civilization development, especially for preserving culture and history. The museum is also used for permanent exhibitions of objects that deserve public attention, such as historical, artistic, and scientific heritage. In this regard, the museum functions as a place to serve learning, educational, and fun needs. However, nowadays, the museum is only considered a place to store antiques and ancient objects. The lack of museum enthusiasts is caused by the perception that museums are not significant places to broaden insight and knowledge. Besides, there is a lack of publications and information about museums. …


Kampung Akuarium Community Participation In Resolving Conflict Between Archeological Resource Preservation And Apartment Building Construction, Shella Dwiastu Hasnawati, Supratikno Rahardjo Jul 2023

Kampung Akuarium Community Participation In Resolving Conflict Between Archeological Resource Preservation And Apartment Building Construction, Shella Dwiastu Hasnawati, Supratikno Rahardjo

International Review of Humanities Studies

Vertical housing is often considered a viable solution to address the high population density in DKI Jakarta. However, it poses a challenge when such housing is situated within Cultural Heritage zones that require preservation. This scenario gives rise to potential conflicts of interest between the preservation of archaeological resources and the development of housing for the public's benefit, as exemplified in Kampung Akuarium. This study aims to elucidate the extent of community involvement in resolving the issues arising from apartment development within cultural heritage zones. It emphasizes the need for balanced community participation to achieve a win-win solution. The research …


New Standards Versus New World: An Examination Of Select South Louisiana Teachers’ Experiences With Next Generation Science Standards In A Virtual Context, Bridget Lemoine Jul 2023

New Standards Versus New World: An Examination Of Select South Louisiana Teachers’ Experiences With Next Generation Science Standards In A Virtual Context, Bridget Lemoine

LSU Doctoral Dissertations

The national K-12 science standards were reformed in April 2013. On March 8, 2017, the state of Louisiana’s Board of Elementary and Secondary Education approved the rewrite of the science standards to align with these national standards, and they were implemented in the middle school science classes. In March 2020, the COVID-19 pandemic began and thrust all students into the virtual learning world. The purpose of this study was twofold: to investigate certain changes made to the science standards in Louisiana and to examine how the pandemic interrupted NGSS implementation in the classroom both with teachers who were familiar with …


The Effect Of Different Natural Waxes To Hydrophobic Properties Of Starch-Based Biodegradable Foams, Ikbal Alexander, Ahyahudin Sodri, Kosuke Mizuno Jul 2023

The Effect Of Different Natural Waxes To Hydrophobic Properties Of Starch-Based Biodegradable Foams, Ikbal Alexander, Ahyahudin Sodri, Kosuke Mizuno

Journal of Environmental Science and Sustainable Development

Biodegradable foam has been vastly developed to replace polystyrene foam. However, its water absorption capacity has become a significant obstacle to being used in food packaging. Therefore, this study aims to assess the effect of incorporating natural waxes as a coating material in producing biodegradable foams. The four natural waxes are soy wax, candelilla wax, beeswax, and carnauba wax. The biodegradable foams were fabricated with cassava starch and rice straw as natural fiber sources using a thermal pressing machine. The Meyer-Rod coating method was adopted to produce high contact angle and highwater resistance starch-based biodegradable foams. Water absorption analysis was …


Addressing The Debate On The Eco-Friendliness Of Indonesian Batik By Water Footprint Approach, Widhi Handayani, Yohanes Budi Widianarko, Alberta Rika Pratiwi Jul 2023

Addressing The Debate On The Eco-Friendliness Of Indonesian Batik By Water Footprint Approach, Widhi Handayani, Yohanes Budi Widianarko, Alberta Rika Pratiwi

Journal of Environmental Science and Sustainable Development

The Indonesian batik is an intangible cultural heritage that contributes to the country's economy but raises environmental pollution. Synthetic dyes are considered to cause pollution, and the natural counterpart is recommended to replace it because natural dyes are considered more eco-friendly than synthetic ones. Therefore, this study examined the Blue Water Footprint (BWF) and Grey Water Footprint (GWF) of the batik household industry by applying synthetic dyeing and comparing the result to the natural dyeing from previous studies. This research used the Water Footprint accounting approach based on the Water Footprint Network, which involves identifying the batik process followed by …


Potential Toxic Elements And Their Carcinogenic And Non-Carcinogenic Risk Assessment In Some Commercially Important Fish Species From A Ramsar Site, Mohammad Belal Hossain, Md Moudud Ahmed, Yeasmin Nahar Jolly, As-Ad Ujjaman Nur, Salma Sultana, Shirin Akter, Jimmy Yu, Bilal Ahamad Paray, Takaomi Arai Jul 2023

Potential Toxic Elements And Their Carcinogenic And Non-Carcinogenic Risk Assessment In Some Commercially Important Fish Species From A Ramsar Site, Mohammad Belal Hossain, Md Moudud Ahmed, Yeasmin Nahar Jolly, As-Ad Ujjaman Nur, Salma Sultana, Shirin Akter, Jimmy Yu, Bilal Ahamad Paray, Takaomi Arai

Faculty, Staff and Student Publications

Potentially toxic elements (PTEs) such as Hg, As, and Pb have become concentrated in the aquatic ecosystem as a result of increased human activities. However, these substances frequently have synergistic or antagonistic effects on the human body or other animals. As a result, there are concerns world-wide that commercially available food products, especially fish, may be contaminated with hazardous elements. In this study, samples of four selected fishes, Gutum (Lepidocephalichthys guntea), Baim (Macrognathus pancalus), Baila (Glossogobius giuris), Meni (Nandus nandus) were analyzed from one of the largest freshwater wetlands (designed as a …


Improved Academic Achievement And Self-Efficacy Through The Participation In Extracurricular Activities Of University Students Previously Diagnosed With Adhd: A Hermeneutic Phenomenological Study, Digory Matthew Williams Jul 2023

Improved Academic Achievement And Self-Efficacy Through The Participation In Extracurricular Activities Of University Students Previously Diagnosed With Adhd: A Hermeneutic Phenomenological Study, Digory Matthew Williams

Doctoral Dissertations and Projects

Due to their transient nature of having short attention spans, causing disruptions in the classroom, and academic shortcomings, students diagnosed with ADHD need non-pharmacological methods to help them achieve academic success. The purpose of this hermeneutic phenomenological study was to describe the lived experiences of college undergraduate students at Arbiter University who have low senses of academic self-efficacy due to having been diagnosed with ADHD. A sample of 10 undergraduate students between the age range of 18 and 22 years old noted they all experienced academic difficulties due to their ADHD diagnosis, had low senses of self-efficacy, and participated in …


The Whole Child Initiative Model Of Care For Those Aging Out Of Residential Care, Ashley Nichole Davis Jul 2023

The Whole Child Initiative Model Of Care For Those Aging Out Of Residential Care, Ashley Nichole Davis

Doctoral Dissertations and Projects

The purpose of this qualitative study is to investigate the type of relationship that exists between the implementation of The Whole Child Initiative model of care in the lives of individuals who have aged out of residential care and both the spiritual and developmental outcomes for these individuals. This study helps to determine if there is a relationship between the existence of the support of the Whole Child Initiative’s model of care for individuals who age out of residential care and their church attendance, use of private religious activities such as prayer or Bible study, experiences with the presence of …


The Effects Of Repertoire Selection And Classroom Configuration On The Middle School Classroom Environment, Bethany Marie Davis Jul 2023

The Effects Of Repertoire Selection And Classroom Configuration On The Middle School Classroom Environment, Bethany Marie Davis

Doctoral Dissertations and Projects

This predictive correlational study examined the effects of classroom configuration and repertoire selection on student perspectives of the middle school choral classroom atmosphere. Despite the general understanding that repertoire affects the classroom atmosphere, how repertoire selection and classroom configuration affect student perspective is still being determined. Student perspectives are vital as they have a significant impact as educators endeavor to create a positive learning environment for choral students. This quantitative study applied a multiple linear regression to predict the results of the Short Test of Musical Preferences and the National School Improvement Partnership’s Classroom Climate Questionnaire Upper Primary. This study …


Evaluating The Need For Return-To-Learn Concussion Protocols In High School Student-Athletes: An Integrative Review, William David Midgette Jul 2023

Evaluating The Need For Return-To-Learn Concussion Protocols In High School Student-Athletes: An Integrative Review, William David Midgette

Doctoral Dissertations and Projects

Over a million high school students are estimated to sustain at least one sports-related concussion annually. Unfortunately, over a third of these student-athletes suffer from post-concussion syndrome, which leads to the question of whether student-athletes are allowed proper time to heal after a concussion or if more can be done to optimize concussion recovery. Proper and optimal recovery post-concussion encompasses both physical and cognitive rest. While concussion management has traditionally focused on the physical aspects of recovery, emphasis has shifted to the cognitive impacts of concussions. There is literature to support that cognitive rest is vitally important, if not equally …


Self-Care For Counselors During The Covid-19 Pandemic, Penney Siddiqui Jul 2023

Self-Care For Counselors During The Covid-19 Pandemic, Penney Siddiqui

Doctoral Dissertations and Projects

COVID-19 took the world by surprise early in 2020, and rapidly became a global threat. While not the first global pandemic declared by the World Health Organization, COVID-19 was different from past pandemics both in the speed of transmission and in the psychosocial impact. Not only did COVID-19 impact the physical health of those who contracted the virus, it also impacted the mental health of the general population. Mental health counselors held a dual role in this pandemic, facing the psychosocial impact themselves while simultaneously providing care for others. Recent studies explored the psychosocial impact on health care professionals and …


A Comparative Study Of Different Practices In Environmental Impact Assessment, Ni Putu Wulan Romianingsih, Suyud Warno Utomo, Udi Syahnoedi Hamzah Jul 2023

A Comparative Study Of Different Practices In Environmental Impact Assessment, Ni Putu Wulan Romianingsih, Suyud Warno Utomo, Udi Syahnoedi Hamzah

Journal of Environmental Science and Sustainable Development

Currently, there are two practices to assess the environmental and social impacts of the power development projects in Indonesia, namely Indonesia Environmental Impact Assessment (EIA) or Amdal and Environmental and Social Impact Assessment (ESIA) based on the International Finance Corporation (IFC) Performance Standards. However, the ESIA practices in Indonesia, in particular, have yet to be thoroughly examined in the academic context. This research compares the procedural features and environmental and socio-economic aspect coverage of Indonesia's EIA against the IFC (IFC PS) ESIA. A document analysis was employed to systematically analyze the main divergences and similarities contrasted with applicable Indonesian regulations …


Seaweed As Bioadsorbent For Nitrogen And Phosphorus Removal, Hanny Meirinawati, A’An Johan Wahyudi Jul 2023

Seaweed As Bioadsorbent For Nitrogen And Phosphorus Removal, Hanny Meirinawati, A’An Johan Wahyudi

Journal of Environmental Science and Sustainable Development

Eutrophication has become a serious environmental problem because of the excessive amounts of nitrogen and phosphorus in the water. Aquaculture waste is one of the drivers of eutrophication. Seaweed is known for its ability to remove nutrients from the water. In Indonesia, research about the efficiency of seaweed in decreasing nutrient concentration in wastewater is still rare. This article reviewed the use of seaweed as an adsorbent for nitrogen and phosphorus removal. This review aims to summarize the efficiency of nutrient removal in various genera of macroalgae. The comparing bioremediation potentials of macroalgae, including growth, nutrient bioaccumulation capacity, and potential …


Konstruktivisme Bruno Latour Dan Implikasinya Terhadap Ide Keagenan Sosiologi, Robertus Robet, U Abdul Rozak R Jul 2023

Konstruktivisme Bruno Latour Dan Implikasinya Terhadap Ide Keagenan Sosiologi, Robertus Robet, U Abdul Rozak R

Masyarakat: Jurnal Sosiologi

Abstract

Latour removes the boundaries between natural sciences and humanities. Science for Latour is cultural practise, at the same time in every cultural practice, nature and objects are also actively involved. With that, Latour's constructivism encourages the emergence of non-human actors as drivers of the societal changes. With that he provoked sociology to expand its subject matter. The Social in sociology must be seen as an association involving human and non-human actors.


Uvrd1 Helicase Of Mycobacterium Tuberculosis That Can Be Activated By Multiple Unique Mechanisms, Ankita Chadda Jul 2023

Uvrd1 Helicase Of Mycobacterium Tuberculosis That Can Be Activated By Multiple Unique Mechanisms, Ankita Chadda

Arts & Sciences Graduate Student Theses and Dissertations

Abstract Mycobacterium tuberculosis (Mtb) causes tuberculosis disease in humans and is one of the leading causes of death worldwide due to infectious agents. During infection, Mtb is exposed to reactive oxygen species and reactive nitrogen intermediates from the host immune response that causes DNA damage. UvrD-like helicases are involved in DNA repair and use energy from ATP hydrolysis to translocate on single stranded DNA (ssDNA) or unwind double-stranded DNA (dsDNA) to remove the damaged DNA strand. Previous studies on UvrD-like helicases have shown that they exist in a monomer-dimer equilibrium and unwind only as dimers in the absence of accessory …


The Third Domain Of T Cells In The Evolution Of Novel Immune Cell Types, Kimberly Anne Morrissey Jul 2023

The Third Domain Of T Cells In The Evolution Of Novel Immune Cell Types, Kimberly Anne Morrissey

Biology ETDs

αβ and γδ T cells play an essential role in the adaptive immune response and are present in the majority of jawed vertebrates. The T cell receptor (TCR) structure and genetic organization have been generally stable throughout 400 million years of gnathostome evolution. However, the TCRδ chain has displayed degrees of plasticity unseen in other TCR isoforms. One such form appears to be a chimera of a TCR chain with an antibody-like binding domain, known as VHδ and has been found a wide array of vertebrates including cartilaginous fish, coelacanths, amphibians, tuataras, birds, crocodilians, and monotreme mammals. Another, more extreme …


Using A Culturable Approach And Metagenomic Analysis To Uncover Gut Bacterial Diversity Of Gray Bats In Kansas, Bobbi Monroe Jul 2023

Using A Culturable Approach And Metagenomic Analysis To Uncover Gut Bacterial Diversity Of Gray Bats In Kansas, Bobbi Monroe

Electronic Theses & Dissertations

USING A CULTURABLE APPROACH AND METAGENOMIC ANALYSIS TO UNCOVER GUT BACTERIAL DIVERSITY OF GRAY BATS IN KANSAS

An Abstract of the Thesis by

Bobbi Monroe

Humans have historically had an ambivalent relationship with bats. In one hand, bats perform an important service to humans by reducing populations of many insect pests. On the other hand, they act as reservoirs of disease as highlighted by the recent Coronavirus pandemic. In the United States, many bat populations have been threatened by white nose syndrome caused by the fungus Pseudogymnoascus destructans. This study was designed to characterize the bacterial diversity associated with the …


Gerontology In Bryony Lavery’S A Wedding Story (2000) And Sebastian Barry’S Hinterland (2002), Rania M Rafik Khalil Jul 2023

Gerontology In Bryony Lavery’S A Wedding Story (2000) And Sebastian Barry’S Hinterland (2002), Rania M Rafik Khalil

English Language and Literature

Old age is perceived as a narrative of decline, recently, an alternative perspective was introduced known as positive aging or Gerotranscendance. This paper examines ageing in Bryony Lavery’s A Wedding Story (2000) and Sebastian Barry’s Hinterland (2002) through the theory of gerontology. Gerontology in British and Irish modern theatre, according to Giovanna Tallone (2020) and Heather Ingman (2018), is a new category in literary studies and theory. The paper aims to examine the challenges of retaining agency in old age in comparison to the notion of aging as a process of inner harmony further proving that despite the process of …


Quantum Reality With Negative-Mass Particles, Mordecai Waegell, Eliahu Cohen, Avshalom C. Elitzur, Jeff Tollaksen, Yakir Aharonov Jul 2023

Quantum Reality With Negative-Mass Particles, Mordecai Waegell, Eliahu Cohen, Avshalom C. Elitzur, Jeff Tollaksen, Yakir Aharonov

Mathematics, Physics, and Computer Science Faculty Articles and Research

Physical interpretations of the time-symmetric formulation of quantum mechanics, due to Aharonov, Bergmann, and Lebowitz are discussed in terms of weak values. The most direct, yet somewhat naive, interpretation uses the time-symmetric formulation to assign eigenvalues to unmeasured observables of a system, which results in logical paradoxes, and no clear physical picture. A top–down ontological model is introduced that treats the weak values of observables as physically real during the time between pre- and post-selection (PPS), which avoids these paradoxes. The generally delocalized rank-1 projectors of a quantum system describe its fundamental ontological elements, and the highest-rank projectors corresponding to …


Remimazolam – Current Status, Opportunities And Challenges, J. Robert Sneyd Jul 2023

Remimazolam – Current Status, Opportunities And Challenges, J. Robert Sneyd

More Faculty of Health Research

The short acting benzodiazepine remimazolam has been well characterised for use during procedural sedation. Onset of hypnotic effect is swifter than midazolam and recovery is faster with a period of antegrade amnesia. Haemodynamic changes associated with remimazolam sedation are modest and there is no pain on injection. General anaesthesia may be induced and maintained by infusion of remimazolam in combination with a suitable opioid. Hypotension is less frequent than when propofol is used. In addition, remimazolam may be a suitable alternative to propofol or etomidate for inducing anaesthesia in haemodynamically compromised patients prior to maintenance with a volatile agent. A …


Predicting Narcissistic Personality Traits From Brain And Psychological Features: A Supervised Machine Learning Approach, Khanitin Jornkokgoud, Teresa Baggio, Md Faysal, Richard Bakiaj, Peera Wongupparaj, Remo Job, Alessandro Grecucci Jul 2023

Predicting Narcissistic Personality Traits From Brain And Psychological Features: A Supervised Machine Learning Approach, Khanitin Jornkokgoud, Teresa Baggio, Md Faysal, Richard Bakiaj, Peera Wongupparaj, Remo Job, Alessandro Grecucci

School of Psychology

Narcissism is a multifaceted construct often linked to pathological conditions whose neural correlates are still poorly understood. Previous studies have reported inconsistent findings related to the neural underpinnings of narcissism, probably due to methodological limitations such as the low number of participants or the use of mass univariate methods. The present study aimed to overcome the previous methodological limitations and to build a predictive model of narcissistic traits based on neural and psychological features. In this respect, two machine learning-based methods (Kernel Ridge Regression and Support Vector Regression) were used to predict narcissistic traits from brain structural organization and from …


Prorelaxant E-Type Prostanoid Receptors Functionally Partition To Different Procontractile Receptors In Airway Smooth Muscle, Ajay P. Nayak, Elham Javed, Dominic R. Villaba, Yinna Wang, Henry P. Morelli, Sushrut D. Shah, Nicholas Kim, Rennolds S. Ostrom, Reynold A. Pannettieri Jr., Steven S. An, Dale D. Tang, Raymond B. Penn Jul 2023

Prorelaxant E-Type Prostanoid Receptors Functionally Partition To Different Procontractile Receptors In Airway Smooth Muscle, Ajay P. Nayak, Elham Javed, Dominic R. Villaba, Yinna Wang, Henry P. Morelli, Sushrut D. Shah, Nicholas Kim, Rennolds S. Ostrom, Reynold A. Pannettieri Jr., Steven S. An, Dale D. Tang, Raymond B. Penn

Pharmacy Faculty Articles and Research

Prostaglandin E2 imparts diverse physiological effects on multiple airway cells through its actions on four distinct E-type prostanoid (EP) receptor subtypes (EP1–EP4). Gs-coupled EP2 and EP4 receptors are expressed on airway smooth muscle (ASM), yet their capacity to regulate the ASM contractile state remains subject to debate. We used EP2 and EP4 subtype-specific agonists (ONO-259 and ONO-329, respectively) in cell- and tissue-based models of human ASM contraction—magnetic twisting cytometry (MTC), and precision-cut lung slices (PCLSs), respectively—to study the EP2 and EP4 regulation of ASM contraction and signaling under conditions of histamine or methacholine (MCh) stimulation. ONO-329 was superior (<0.05) to ONO-259 in relaxing MCh-contracted PCLSs (log half maximal effective concentration [logEC50]: 4.9 × 10−7 vs. 2.2 × 10−6; maximal bronchodilation ± SE, 35 ± 2% vs. 15 ± 2%). However, ONO-259 and ONO-329 were similarly efficacious in relaxing histamine-contracted PCLSs. Similar differential effects were observed in MTC studies. Signaling analyses revealed only modest differences in ONO-329– and ONO-259–induced phosphorylation of the protein kinase A substrates VASP and HSP20, with concomitant stimulation with MCh or histamine. Conversely, ONO-259 failed to inhibit MCh-induced phosphorylation of the regulatory myosin light chain (pMLC20) and the F-actin/G-actin ratio (F/G-actin ratio) while effectively inhibiting their induction by histamine. ONO-329 was effective in reversing induced pMLC20 and the F/G-actin ratio with both MCh and histamine. Thus, the contractile-agonist–dependent differential effects are not explained by changes in the global levels of phosphorylated protein kinase A substrates but are reflected in the regulation of pMLC20 (cross-bridge cycling) and F/G-actin ratio (actin cytoskeleton integrity, force transmission), implicating a role for compartmentalized signaling involving muscarinic, histamine, and EP receptor subtypes.


Cutting-Edge Cancer Research Lab Opens Operations At Pepper Place, Public Relations Jul 2023

Cutting-Edge Cancer Research Lab Opens Operations At Pepper Place, Public Relations

Browse All News

No abstract provided.


A Deep Learning Onion Peeling Approach To Measure Oral Epithelium Layer Number, Xinyi Zhang, Frederico O Gleber-Netto, Shidan Wang, Kevin W Jin, Donghan M Yang, Ann M Gillenwater, Jeffrey N Myers, Renata Ferrarotto, Curtis R Pickering, Guanghua Xiao Jul 2023

A Deep Learning Onion Peeling Approach To Measure Oral Epithelium Layer Number, Xinyi Zhang, Frederico O Gleber-Netto, Shidan Wang, Kevin W Jin, Donghan M Yang, Ann M Gillenwater, Jeffrey N Myers, Renata Ferrarotto, Curtis R Pickering, Guanghua Xiao

Faculty, Staff and Student Publications

Head and neck squamous cell carcinoma (HNSCC), specifically in the oral cavity (oral squamous cell carcinoma, OSCC), is a common, complex cancer that significantly affects patients' quality of life. Early diagnosis typically improves prognoses yet relies on pathologist examination of histology images that exhibit high inter- and intra-observer variation. The advent of deep learning has automated this analysis, notably with object segmentation. However, techniques for automated oral dysplasia diagnosis have been limited to shape or cell stain information, without addressing the diagnostic potential in counting the number of cell layers in the oral epithelium. Our study attempts to address this …


Inhibition Of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition In Melanoma Tumors And May Improve Immunotherapy Efficacy By Reducing T-Cell Exhaustion, Yasunari Fukuda, Sun-Hee Kim, Matias A Bustos, Sung-Nam Cho, Jason Roszik, Jared K Burks, Hong Kim, Dave S B Hoon, Elizabeth A Grimm, Suhendan Ekmekcioglu Jul 2023

Inhibition Of Microsomal Prostaglandin E2 Synthase Reduces Collagen Deposition In Melanoma Tumors And May Improve Immunotherapy Efficacy By Reducing T-Cell Exhaustion, Yasunari Fukuda, Sun-Hee Kim, Matias A Bustos, Sung-Nam Cho, Jason Roszik, Jared K Burks, Hong Kim, Dave S B Hoon, Elizabeth A Grimm, Suhendan Ekmekcioglu

Faculty, Staff and Student Publications

The arachidonic acid pathway participates in immunosuppression in various types of cancer. Our previous observation detailed that microsomal prostaglandin E2 synthase 1 (mPGES-1), an enzyme downstream of cyclooxygenase 2 (COX-2), limited antitumor immunity in melanoma; in addition, genetic depletion of mPGES-1 specifically enhanced immune checkpoint blockade therapy. The current study set out to distinguish the roles of mPGES-1 from those of COX-2 in tumor immunity and determine the potential of mPGES-1 inhibitors for reinforcing immunotherapy in melanoma. Genetic deletion of mPGES-1 showed different profiles of prostaglandin metabolites from that of COX-2 deletion. In our syngeneic mouse model, mPGES-1-deficient cells exhibited …


Complexity Heliophysics: A [New] System Science That Transcends The Previous Boundaries Of Our Field, Ryan M. Mcgranaghan, Seebany Datta-Barua, Jeffrey Thayer, Joe Borovsky, Jay R. Johnson, Simon Wing, Dan Baker, Massimo Materassi Jul 2023

Complexity Heliophysics: A [New] System Science That Transcends The Previous Boundaries Of Our Field, Ryan M. Mcgranaghan, Seebany Datta-Barua, Jeffrey Thayer, Joe Borovsky, Jay R. Johnson, Simon Wing, Dan Baker, Massimo Materassi

Faculty Publications

Synopsis

1. The 21st century is the time of complexity. We delineate it and its importance as necessary to solve ‘wicked problems.’

2. Inherently transdisciplinary, trans-scale, and interconnected to living systems, the solution to Heliophysics’ identity crisis and to unlock the next generation of scientific discovery may be to embrace complexity.

3. With the right foresight, direction, and incentive over the next ten years, Heliophysics can become a beacon for how all of society thinks about and does complexity science.


The Effectiveness Of The Rules Of International Criminal Responsibility In The Face Of Biological Weapons., Inaam Barkouk Jul 2023

The Effectiveness Of The Rules Of International Criminal Responsibility In The Face Of Biological Weapons., Inaam Barkouk

BAU Journal - Journal of Legal Studies - مجلة الدراسات القانونية

This study dealt with the talk about biological weapons that have been used in wars since ancient times, and whose reappearance has re-emerged to attract the attention of peoples and governments in our time, and then determine the nature of the acts resulting from them, and the international criminal responsibility resulting from the violations committed through them as one of the most deadly weapons that result in International crimes against humans and other living creatures We reached the ambiguity surrounding some international criminal legal rules and explained how they are adapted to the actions resulting from these weapons and the …


Investigating The Common Perceptual Qualities Of Urban Morphology And Subjective Wellbeing Scales For Urban Mobility Studies: A Literature Review., Dina Mahmoud Abdelrashid Noseir, Marwa A. Khalifa, Yehya M. Serag, Mohamed A. El Fayoumi Jul 2023

Investigating The Common Perceptual Qualities Of Urban Morphology And Subjective Wellbeing Scales For Urban Mobility Studies: A Literature Review., Dina Mahmoud Abdelrashid Noseir, Marwa A. Khalifa, Yehya M. Serag, Mohamed A. El Fayoumi

Future Engineering Journal

The impact of the built environment, urban form, and urban morphology on individual's perception, experience and wellbeing has been the focus of many studies in the past few decades. Additionally, the impact of the built environment and its spatial characteristics has been recently studied from different approaches. Literature review shows that various research has been conducted on the impact of the built environment and travelers’ behavior and modal choice. However, few studies have been conducted on the impact of the built environment on travelers’ perception during mobility. Thus, this manuscript attempts to theoretically establish a link between the epistemology of …


Missing Value Imputation For Single Omics And Multi-Omics Data, Meng Song Jul 2023

Missing Value Imputation For Single Omics And Multi-Omics Data, Meng Song

Dissertations

The integration analyses of multi-omics data have the advantages of extending our understanding of biological system across multiple omics layers, unraveling the functional mechanism of complex disease development, and refining the discovery of novel drug targets. However, multi-omics studies often face challenges such as data heterogeneity, missing values problem, interpretability, and imbalance classes. Among these challenges, the missing values problem is a critical issue for large cohort studies as not all samples will get a complete measurement for all the omics layers. To address the problem of missing values in multi-omics data, I focused on the imputation of completely missing …