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Authorizations, Prices, And Labeling Differences Of Therapeutic Biologics Marketed In The United States And Saudi Arabia, Turki Altowairgi

Pharmaceutical Sciences (PhD) Dissertations

BACKGROUND: Since 1982, Saudi Arabia (SA) and the United States (US) have seen an increase in therapeutic biologics authorization. However, each country has regulatory regulations governing the approval of these cutting-edge drugs. The high cost of biologics financially burdens healthcare systems and delays patient access to these treatments. Sometimes a company selling the same medications in various countries will have conflicting information on drug labels.

OBJECTIVES: This study compared the characteristics of therapeutic biologics authorization by the Saudi Food and Drug Authority (SFDA) and Food and Drug Administration (FDA) as of December 31, 2021. The study also compared the US …

A Genotype × Environment Experiment Reveals Contrasting Response Strategies To Drought Between Populations Of A Keystone Species (Artemisia Tridentata; Asteraceae), Anthony E. Melton, Kara Moran, Peggy Martinez, Paige Ellestad, Erin Milliken, Walker Morales, Andrew W. Child, Bryce A. Richardson, Marcelo Serpe, Stephen J. Novak, Sven Buerki

Biology Faculty Publications and Presentations

Western North America has been experiencing persistent drought exacerbated by climate change for over two decades. This extreme climate event is a clear threat to native plant communities. Artemisia tridentata is a keystone shrub species in western North America and is threatened by climate change, urbanization, and wildfire. A drought Genotype × Environment (G × E) experiment was conducted to assess phenotypic plasticity and differential gene expression in A. tridentata. The G × E experiment was performed on diploid A. tridentata seedlings from two populations (one from Idaho, USA and one from Utah, USA), which experience differing levels of …

A Novel Approach To The Nest Site Characterization Of Two Species Of Critically Endangered Vulture In Gorongosa National Park, Mozambique, Rebecca Colleen Bishop

Boise State University Theses and Dissertations

Vulture populations in Africa face extinction as the result of numerous human-generated threats. Existing geographical and ecological knowledge gaps urgently need to be filled to support targeted conservation action across the vast continent, and ideally halt further decline. My study focuses on two Critically Endangered African vulture species - the White-backed Vulture (Gyps africanus) and the especially rare and poorly understood White-headed Vulture (Trigonoceps occipitalis) - in one of the most understudied countries, Mozambique, and from within a protected area, Gorongosa National Park. Formal documentation of breeding densities, nest site characteristics, and timing is limited for …

Electromagnetic Simulations Of The Lansce Chopper Structure, Yusuf Sahin

Electrical and Computer Engineering ETDs

Particle accelerators are important for basic research as well as in applications such as ion implantation and cancer therapy. One important accelerator is the Los Alamos Neutron Science Center (LANSCE) located at Los Alamos National Laboratory (LANL) that primarily produces neutrons for research. The beam chopper simulation described here is a study to provide better modeling of this subsystem of LANSCE. A chopper is a device in which particles are intermittently sliced and directed to a target and/or experiment. The simulations in this thesis are used to analyze the correct operating parameters of the chopper. A good chopper model can …

Comparison Of Random Coupling Model To Stochastic Dyadic Green’S Function When Coupling To A Distributed Port, Evelyn Anne Dohme

Electrical and Computer Engineering ETDs

The Random Coupling Model (RCM) provides statistical representation of coupling between ports in a highly overmoded resonant cavity based on knowledge of radiation impedances of system ports and cavity properties. A recent variant of RCM, the Stochastic Dyadic Green’s Functions (S-DGF), provides the statistical distribution of fields in the cavity. By using Source Reconstruction Methods (SRM) to approximate equivalent surface currents, I hypothesized that the S-DGF can calculate the fields at their location, enabling a statistical estimate of the coupled power. Using nearfield radiation from simple patch antenna simulations and the SRM to estimate the equivalent fields and account for …

Lgbtq+ Support Services At Community Colleges From An Executive Leadership Perspective: An Interpretative Phenomenological Analysis, Chris Kukenberger

Education Doctoral

Community colleges were created to serve regional communities while removing barriers to education for marginalized populations. Community colleges have thus made public commitments to serve minoritized populations including those of the lesbian, gay, bisexual, transgender, and queer or questioning (LGBTQ+) identities. Despite the fact that community colleges are making public claims of commitment to diversity, equity, inclusion, and belonging, our nation’s LGBTQ+ population is being left out. The purpose of this study was to explore the misalignment between espoused beliefs and practice with respect to support being offered to LGBTQ+ students through the lens of social capital theory as viewed …

Generation Z’S Perceptions Of Hunting And Conservation Efforts In Arkansas, Hannah Ferguson

Graduate Theses and Dissertations

Hunting participation numbers have steadily declined since the 1980s and Generation Z is not engaging in hunting. Hunting is one of the most effective tools for managing wildlife populations and ensuring the success and local ecosystem conservation. Many wildlife stewardship institutions, such as Arkansas Game and Fish Commission in Arkansas, are funded by sales taxes imposed on firearms, ammo, and archery equipment. With a decline in hunting participation, it is imperative state-run wildlife stewardship organizations and other hunting institutions learn the best practices for communicating with younger generations. This study sought to understand Generation Z’s perceptions of hunting and conservation …

Effects Of Supplemental Trace Minerals As Amino Acid Complexed Or Inorganic Sources For Beef Cattle From Receiving Through Finishing, Robin Ashley Cheek

Graduate Theses and Dissertations

The objective of experiments was to investigate the effects of inorganic or amino acid-complexed sources of trace minerals on health, gain performance, liver mineral concentrations, and carcass characteristics of beef heifers from receiving through finishing. To investigate the effects of inorganic or amino acid-complexed sources of trace minerals (zinc, copper, manganese, and cobalt) on performance and morbidity of beef heifers during the receiving period, crossbred beef heifer calves arriving on 3 delivery dates were used in a 42-day receiving trial. Treatments consisted of supplemental zinc (360 mg/d), copper (125 mg/d), manganese (200 mg/d), and cobalt (12 mg/d) from complexed (Availa-4, …

Examination Of A Measure To Assess Clients’ Perceptions Of The Client-Provider Relationship In Home Visiting Services, Bethelhem Belachew

Dissertations

Home visiting services are prevention-or intervention-based programs provided to caregivers during the prenatal period through the first few years of a child’s development (Shonkoff & Phillips, 2000). Engagement in services is documented to improve caregivers’ knowledge of child development and parenting practices (e.g., home safety, nutrition; Ammerman et al., 2006). Despite these benefits, programs are challenged with high levels of attrition (Gomby, Culross, & Behrman, 1999). One reliable predictor of client engagement in services is the client-provider relationship. However, measures that have been developed to assess the clients’ perception of their relationship with their home visitor relationship are limited (Girvin …

Exploring Biotic And Abiotic Constraints On Competition For Signal Space Within Birdsong Communities, Joanna M. Sblendorio

Dissertations

With the acceleration of climate change and the conversion of natural ecosystems to human-dominated landscapes, there is concern for the persistence of biodiversity amid novel biotic and abiotic factors. An important outcome of shifting species distributions and environmental disturbance is the formation of novel assemblages. For animals that vocalize for mate attraction and resource defense, the introduction of new species into communities may alter availability of acoustic space for signaling and affect detection of signals by conspecifics. Thus, to minimize signal overlap, species should partition signal space and thereby inhabit well-defined acoustic niches. Yet mixed evidence exists regarding signal space …

2023-2024 Faculty Senate Roster, Faculty Senate, East Tennessee State University

Faculty Senate Agendas and Minutes

No abstract provided.

Design, Synthesis, And Evaluation Of Oleyl-Wrh Peptides For Sirna Delivery, Mrigank S Rai

Pharmaceutical Sciences (MS) Theses

The delivery of nucleic acid therapeutics across various cell membranes has always been one of the major challenges. Cell-penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) have been promising for siRNA delivery. Therefore, to enhance siRNA delivery and efficient silencing of the STAT3 gene, herein, we hypothesized to use of fatty acylation with oleyl chain to our newly designed cell-penetrating peptide (WRH) to evaluate their silencing efficiency in breast and ovarian cancer cells. Therefore, the oleyl conjugated (WRH)_n (n=1-4) peptides were synthesized using Fmoc/tBu solid-phase peptide chemistry, followed by purification using Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC), …

A Manual For The Recovery Of Cbrne (Chemical, Biological, Radiological, Nuclear, And Explosive) Contaminated Human Remains, Patrick Barchett

Department of Anthropology: Theses and Student Research

Despite many international agreements and treaties prohibiting the use of CBRNE (Chemical, Biological, Radiological, Nuclear, and Explosive) weaponry, the proliferation of contaminated human remains displays the historic and continued use of inhumane war efforts. Due to the complications of recovery, contaminated human remains are often left unrecovered and unidentified. This thesis works to create a framework for the recovery of contaminated human remains for organizations with a focus on creating safe and sustainable working environments for those conducting the recovery. Much of this thesis assumes the remains are being recovered from interred mass graves. This thesis provides an introduction to …

Cave Research Foundation Newsletter, Volume 51, No. 3, August 2023, Laura Lexander

Cave Research Foundation Newsletter

Contents: President's Column -- CRF Received $1,585 from Amazon Donation Program -- CRF's Hamilton Valley Facility Transitions to Long-Term Maintenance -- Google Group for Eastern Operations -- Regional Expedition Reports

Gemcitabine Resistant Pdac Cell- Neutrophil Interaction Regulates Their Proliferation And Survival, Lauren Abrahams, Reegan Sturgeon, Michael Maher, Parker Tinsley, Ester Johnson, Rakesh K. Singh

Posters: 2023 Summer Undergraduate Research Program

Malignant tumors are inherently pro-inflammatory, and infiltrating leukocytes are thought to be critical for tumor maintenance and progression. Infiltrating cells and molecules driving tumor-associated inflammation have considerable potential as therapeutic targets, yet this area remains relatively under-explored. Neutrophils are the most prevalent leukocyte in the innate immune system and have been shown to play an essential role in cancer progression. Previously our lab has reported that as pancreatic ductal adenocarcinoma (PDAC) disease progresses, there is an increase in the infiltration of neutrophils. The specific objective of this study is to determine the role of neutrophil-PDAC cell interaction in therapy resistance. …

Exposure To A Phthalate Mixture Disrupts Ovulatory Progesterone Receptor Signaling In Human Granulosa Cells In Vitro, Patrick R. Hannon, James W. Akin, Thomas E. Curry Jr

UK CARES Faculty Publications

Exposure to phthalates disrupts ovarian function. However, limited studies have investigated the effects of phthalate mixtures on ovulation, especially in women. Human granulosa cells were used to test the hypothesis that exposure to a phthalate mixture (PHTmix) disrupts progesterone (P4)/progesterone receptor (PGR) signaling, which is a crucial pathway for ovulation. In addition, progestin and cyclic adenosine 3′, 5′-monophosphate (cAMP) supplementation were tested as methods to circumvent phthalate toxicity. Granulosa cells from women undergoing in vitro fertilization were acclimated in culture to regain responsiveness to human chorionic gonadotropin (hCG; clinical luteinizing hormone analogue). Granulosa cells were treated with or without hCG, …

Long-Term Spring Through Fall Capture Data Of Eptesicus Fuscus In The Eastern Usa Before And After White-Nose Syndrome, Molly Simonis, Lynn K. Hartzler, Joshua Campbell, Timothy C. Carter, Lisa Noelle Cooper, Katelin Cross, Katherine Etchison, Traci, R. Andrew King, Richard J. Reynolds, Yasmeen Samar, Michael Yasmeen, Sarah Stankavich, Gregory G. Turner, Megan A. Rúa

Biological Sciences Faculty Publications

Emerging infectious diseases threaten wildlife populations. Without well monitored wildlife systems, it is challenging to determine accurate population and ecosystem losses following disease emergence. North American temperate bats present a unique opportunity for studying the broad impacts of wildlife disease emergence, as their federal monitoring programs were prioritized in the USA throughout the 20 th century and they are currently threatened by the invasive fungal pathogen, Pseudogymnoascus destructans ( Pd ), which causes white-nose syndrome. Here we provide a long-term dataset for capture records of Eptesicus fuscus (big brown bat) across the eastern USA, spanning 16 years before and 14 …

Academic Motivation Decreases Across Adolescence For Youth With And Without Attention-Deficit/Hyperactivity Disorder: Effects Of Motivation On Academic Success, Zoe Smith, Marcus Flax, Stephen P. Becker, Joshua Langberg

Psychology: Faculty Publications and Other Works

This longitudinal study examined growth trajectories of academic motivation in youth with and without attention-deficit/hyperactivity disorder (ADHD) across the important developmental transition from middle school to high school, and associations with academic success. Consistent with self-determination theory (SDT) of motivation, trajectories of amotivation, extrinsic motivation, and intrinsic motivation were modeled.

Media Multitasking And Neuroticism Influences On Sustained Attention As Observed Through Pupillometry In Uta Students, Jessica E. Nwankwo

2023 Spring Honors Capstone Projects - Archive

Media multitasking (MMT) is becoming more common, but potentially at the cost of memory and attention. Neuroticism, a Big Five inventory measure, could reveal connections to the influence media multitasking may have on attentional control. The present study aimed to observe the impacts of media multitasking and neuroticism on sustained attention, as measured by pupillometry. Over the span of 4 weeks, participants completed several tasks, with the Sustained Attention to Response Task (SART) being the most notable, as measures of their cognitive performance. Participants’ changes in pupil sizes were recorded, and participants completed several surveys, with The Big Five Inventory …

"Things Can Get Unsavory": Professional Interactions, Social Capital, Organizational Identification Among University Resident Assistants, Michael L. Tidwell

All Theses

University resident assistants (RAs) have become a central component of modern higher education and community-oriented residential student experiences. RAs are increasingly responsible for not only community development and engagement of residential students, but also administrative and disciplinarian responsibilities (Boone et al., 2016; Conn, 2020). As a result, RAs face increased feelings of burnout (DuBose, 2020; Stoner, 2017), which research connects to higher turnover intentions and lower job satisfaction (Stoner, 2016, 2017). While most literature on RAs focuses on identification with various social groups (e.g., race, gender, sexuality), organizational identification (OI) – a deep-rooted sense of connection with an organization’s goals …

The Potential Of Iron Electrodes In Electrochemical Cells For The Stabilization Of Synthetic Urine, Skyler Voisin

All Theses

Source separation and urine treatment present the opportunity to significantly reduce influent concentrations of nitrogen and phosphorus in wastewater treatment plants and to capture those minerals for reuse. This study aims to use electrochemical cells with a sacrificial iron electrode to produce hydrogen peroxide in situ for the stabilization of urea while dissolving ferrous iron ions to promote the precipitation of phosphate into compounds such as vivianite (Fe₃ (PO₄)₂ ∙ 8 H₂O), a precipitate with potential uses in agriculture and manufacturing. Synthetic urine samples were treated as anolyte, then were given time to form …

Impacts Of Dam Removal On Cyanobacteria Blooms And Zooplankton Community In Hypereutrophic Upper Klamath Lake, Pruett Noelle Kasey

Biology Theses - Archive

The Chiloquin Dam was removed from the Sprague River in 2008 to restore the natural hydrology of Upper Klamath Lake (UKL), allow fish access to historical spawning grounds, and alleviate the effects of long-term eutrophication. This provided a natural opportunity to investigate the effects of restoration efforts on eutrophication. Using a 10-year dataset including 5 years before and 5 years after dam removal, we developed a consensus modeling approach to investigate factors contributing to the cyanobacteria blooms, observe changes in the ecosystem since the recovery efforts, and to assess the performances of three model types: logistic regression, random forest, and …

Long Non-Coding Rnas In Inflammation, Macrophage Activation, And Inflammatory Human Diseases, Avisankar Chini

Chemistry & Biochemistry Dissertations - Archive

Inflammation and immune signaling is central to infection and diseases. Growing evidence suggests that along with protein coding genes, long non-coding RNAs (lncRNAs) play a critical role in disease onset, combat, and recovery against pathogen, damaged and self-altered cells. Our lab has been extensively studying the role of lncRNA HOTAIR (HOX transcript antisense intergenic RNA) in gene regulation and epigenetics, and eventually discovered its hidden function regulating inflammation and immune signaling in macrophage, a major type of cell involved in immunity. Previous scholars in our lab have successfully demonstrated lncRNA HOTAIR’s regulatory molecular mechanism elucidating its specific role in cellular …

Experimental Investigation Of Water Quality Impact On The Compressive Strength Of Concrete, Shayan Sharifzad

Civil Engineering Dissertations - Archive

Water is an indispensable component in concrete, as it enables crucial chemical reactions. Therefore, the quality of water used in concrete plays a vital role in its performance. Contaminated water, sewage, or high-salt water can disrupt the cement's setting process and overall performance. As a result, it is crucial to prioritize the use of drinking water or water of equivalent quality in concrete production. While the ideal water-to-cement ratio for concrete is typically around 0.20, practical considerations often require a higher water content ranging from 0.30 to 0.70. This increased water consumption is necessary to ensure workability and achieve optimal …

Molecular Mechanisms That Regulate The Stress Response In A. Baumannii, Feroz Ahmed

Biology Dissertations - Archive

Acinetobacter baumannii is particularly problematic in hospital settings, where infections can occur in a range of tissues. This bacterium can endure extreme stress from various antimicrobial agents, biocides, host immune response etc. Not much is known about how these bacteria react to such high stress. A. baumannii also possesses a unique ability to inactivate lipooligosaccharide (LOS) biosynthesis, which is an essential molecule in most Gram-negative bacteria. LOS is enriched in the outer membrane and is the targeted by the last-resort antibiotic, colistin. LOS-deficient A. baumannii is highly resistant to the list-line antimicrobial. Previously, our lab discovered that a two-component system, …

You Don't Need Eyes To See: The Lived-Experience Of College Graduates Who Are Black Men, Born Into Poverty, And Living With A Visual Impairment, Ronald Dillard

Dissertations

The following study seeks to answer this research question: What is the lived experience of college graduates who are Black men, born into poverty, and living with a visual impairment? The researcher has used intersectionality as an aspect of Critical Race Theory (CRT) to conceptualize the research question and develop an interview protocol.

The researcher has conducted in-depth interviews for this qualitative inquiry, resulting in a narrative study. Purposeful sampling was implemented to identify three participants who fit the criteria of being a Black man, born into poverty, and living with a visual impairment. Data was reorganized to tell the …

Sex-Specific Responses To Gnrh Challenge, But Not Food Supply, In Kittiwakes: Evidence For The “Sensitivity To Information” Hypothesis, Shannon Whelan, Z Morgan Benowitz-Fredericks, Scott A. Hatch, Charline Parenteau, Olivier Chastel, Kyle H. Elliott

Faculty Journal Articles

Seasonal timing of breeding is usually considered to be triggered by endogenous responses linked to predictive cues (e.g., photoperiod) and supplementary cues that vary annually (e.g., food supply), but social cues are also important. Females may be more sensitive to supplementary cues because of their greater role in reproductive timing decisions, while males may only require predictive cues. We tested this hypothesis by food-supplementing female and male colonial seabirds (black-legged kittiwakes, Rissa tridactyla) during the pre-breeding season. We measured colony attendance via GPS devices, quantified pituitary and gonadal responses to gonadotropin releasing hormone (GnRH) challenge, and observed subsequent laying phenology. …

Effects Of Environmental Pollutants On Liver Disease: Role Of The Gut-Liver Axis., Ngozi Victoria Adiele

Electronic Theses and Dissertations

Polychlorinated biphenyls (PCBs) and polystyrene (PS) microplastics are environmental pollutants associated with various diseases including toxicant associated fatty liver disease (TAFLD). Previously, exposure to Aroclor 1260 (a PCB mixture) has been shown to exacerbate TAFLD, partly through Aroclor 1260 induced gut dysbiosis. Studies has also demonstrated that PS exposure alters gut microbiome composition and induced obesity. However, the effects of Aroclor 1260 on the gut and the effects of PS on the liver are still understudied. Therefore, we hypothesize that environmental pollutants will disrupt the gut-liver axis through changes in gut and its microbiome as well as changes in liver …

Interactive Computer-Based Simulations As Exploratory Learning Activities., Derek Mcclellan

Electronic Theses and Dissertations

Typical college lectures follow a direct instruction framework, where instructors deliver a lecture, followed by an activity. Exploratory learning flips this routine by providing students with an activity prior to instruction. Research suggests that this inversion benefits students’ conceptual understanding and ability to transfer their knowledge. The majority of exploratory learning tasks in the literature are problem-solving activities. The current work investigates the use of computer-based simulations during exploratory learning, and whether manipulating the cognitive load of the activity impacts learning. In Experiment 1, undergraduate students (N=66) were randomly assigned to explore a simulation-based circuit construction activity prior …

Why Are Measures Of Depression Imperfectly Correlated? An Empirical Investigation., Eric Joseph Smith

Electronic Theses and Dissertations

Depression remains one of the most prevalent and impactful mental health disorders worldwide. A large number of measures of depressive symptoms are currently available, all designed to assess the same underlying construct. However, the measures tend not to correlate highly with one another. Measurement error cannot fully account for this observation, suggesting that clinical heterogeneity – that is, differences in symptom coverage across measures – might contribute to the lower-than-expected correlation between measures. We conducted two concurrent studies to examine this hypothesis. In Study 1, we developed a coding scheme to categorize items into one of 10 symptom categories. We …