Digital Commons Network^™

In Vitro And In Silico Evaluation Of Calcined Chicken Eggshell Powder As An Antibacterial Agent Against Staphylococcus Aureus, Hadi Kurniawan, Hariyanto Ih, Fajar Nugraha, Siti Nani Nurbaeti, Inarah Fajriaty, Ardi Kurniawan, Ridho Maulana Difa

Makara Journal of Science

Staphylococcus aureus is a major Gram-positive pathogen that is increasingly resistant to antibiotics, significantly contributing to antimicrobial resistance (AMR)-related deaths. Therefore, this study aimed to examine the antibacterial activity of calcined chicken eggshell powder (CCEP), a waste-derived material rich in calcium compounds. CCEP was prepared by calcining eggshell powder at 900 °C for 3 hours. Its antibacterial potential was evaluated using in vitro assays, including agar disc diffusion and broth microdilution, as well as in silico molecular docking against penicillin-binding protein 4 (PBP4, PDB ID: 3HUM). The in vitro results showed that a 20% (w/v) CCEP solution in glycerol produced …

Holistic Approach Of Homoeopathy In Treatment Of Multimorbidity: A Case Report, Divya Verma, Nitin Kumar Saklani, Arun Kumar

Indian Journal of Research in Homoeopathy

Introduction: Multimorbidity, a rise in all ages, is a challenge for health care systems that are focused on single-disease management. Homoeopathy has shown competence in the management of chronic diseases, whether they occur as a single ailment or as multimorbidities. Case Summary: A 25-year-old female suffering from symptoms of PCOS, like irregular menses, secondary dysmenorrhea and secondary amenorrhea, along with chronic migraine visited the OPD. She also developed renal calculi during the previous homoeopathic treatment. Her condition improved through homoeopathic medicines Pulsatilla and Lycopodium. The case is reported according to HOM-CASE guidelines. The assessment of causal attribution of homoeopathic …

Biogasification Potential Of Medium- To High-Rank Coals And Its Controlling Mechanisms At A Molecular Structural Level, Bao Yuan, Li Jiajun, Li Dan, Chen Xueru, Wang Xiaojing

Coal Geology & Exploration

Objective Coals with varying metamorphic grades differ significantly in the potential for methane generation through microbial degradation. Medium- to high-rank coals can generate a substantial volume of methane through microbial degradation. However, key factors governing their biogasification potential remain poorly understood. This study aims to identify the dominant factors controlling the potential of medium- to high-rank coals for methane generation through microbial degradation, as well as relevant controlling mechanisms, from the perspective of molecular structures.Methods The Carboniferous-Permian medium- to high-rank coals along the eastern margin of the Ordos Basin were investigated in this study. Using experiments on the hydrocarbon …

Comparative Analysis Of Clearing Methods For 3d Imaging Of The Vasculature In Mineralized Mouse Tissues, Azeez O Ishola, Athira Pillai, Taeyong Ahn, Re-Join Consortium, Chih-Wei Hsu, Brendan Lee, Nele Haelterman, Joshua D Wythe

Faculty, Staff and Students Publications

Historically, visualization of vascular networks within the musculoskeletal system, particularly in mineralized tissues such as bones and joints, has been limited to conventional 2D histological approaches. Recent advances in optical tissue clearing technologies and fluorescence imaging approaches in whole, intact tissues offer an entrée to interrogate the vasculature at unprecedented resolution during both musculoskeletal development and in pathologic contexts in three dimensions. However, these clearing techniques were originally not developed for imaging hard mineralized tissues, such as the femur and tibia. Herein, we have optimized tissue decalcification conditions and compared aqueous- and solvent-based tissue clearing approaches to establish an optimal …

Translating Multi-Omics Into Healthcare: Requisites For Scalable And Equitable Implementation, Birute Tumiene, David R Adams, Robert Allaway, Maria J Barrero, Chun-Hung Chan, Víctor Faundes, Vanessa S Fear, Polina Glezer, Claudia Fuchs, Tudor Groza, Elisa J F Houwink, Saumya Shekhar Jamuar, Mary Catherine V Letinturier, Richa Madan Lomash, Ratna Dua Puri, Juergen K V Reichardt, Ruty Mehrian-Shai, Francois H Van Der Westhuizen, Gaurav K Varshney, Shinya Yamamoto, Gareth Baynam

Faculty, Staff and Students Publications

Multi-omics in combination with advanced computational methodologies synthesizes diverse omics data to provide deeper insights into molecular interactions and offers transformative potential for unravelling phenomenon behind disease complexities, improving diagnostics, disease prevention, and personalized treatments. This integrative strategy enables our understanding of gene-environment relationships, chronic disease progression, and the intricate molecular pathways involved in health. Effective multi-omics analyses require robust data sharing, accessibility, interoperability, and governance, which are critical for linking genomic elements to phenotypic traits. The Global Alliance for Genomics and Health advocates for responsible data-sharing practices, by promoting key principles such as transparency and equity. By emphasizing a …

Incidence Of Autoimmune Diseases In Children With Atopy Treated With Dupilumab, Stanislaw J Gabryszewski, Kathryn Hirabayashi, Morgan Botdorf, Mitchell Maltenfort, Christopher B Forrest, Theresa W Guilbert, Madeline Schutt, Hiroki Morizono, Gerardo Vazquez Garcia, Anna Cristina Garza-Mayers, Joseph Demetrius Hernandez, Sara Anvari, Suchitra Rao, Jonathan M Spergel

Faculty, Staff and Students Publications

Background: The type 2 inflammation-blocking agent dupilumab has gained traction as an effective treatment of multiple atopic diseases. New-onset autoimmune manifestations have been infrequently reported in dupilumab-treated atopic patients, primarily among adults. Autoimmune outcomes in atopic children on dupilumab are less clear.

Objective: We aimed to determine if dupilumab treatment of atopic children is associated with increased autoimmune or autoinflammatory disease diagnosis risk.

Methods: Using a multi-institutional electronic health record database composed of 10 PEDSnet academic health systems, we performed a retrospective cohort study of children aged 6-17 with atopy (ie, moderate-to-severe atopic dermatitis and/or persistent asthma, as defined by …

Supplemental Data For Gulf Coast Walleye Edna Survey, Kevin W. Jones

Research Data

This file contains the full eDNA collection and amplification dataset for:

Jones, K.W. (2026). Development and application of an eDNA protocol for the detection of Gulf Coast Walleye (Sander vitreus) in Mississippi [Thesis submitted for publication]. Department of Wildlife, Fisheries, and Aquaculture, Mississippi State University.

Extending The Geometric Phase To Relativistic Spacetime, Sajid Raihan Akash

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

The Berry phase [3] is traditionally understood as a geometric phase acquired during cyclic adiabatic evolution, often interpreted as the flux of an effective “magnetic field” through a solid angle in parameter space. In this thesis, we investigate situations in which a geometric phase arises even when no spatial solid angle is enclosed, revealing the limitations of the standard purely spatial interpretation. We first review the Berry phase for a spin-½ particle in a slowly varying magnetic field and analyze scenarios in which the system’s eigenstate is changed during the adiabatic evolution. We show that the resulting phase can be …

Discovery Of Quasi-Carbon Nanotube Structures In Tectonically Deformed Coals And Their Formation Mechanisms, Li Yunbo, Wang Rongqi, Song Dangyu, Wang Chengtao, Li Qiang, Yi Ke, Wang Yuanyuan, Pan Jienan

Coal Geology & Exploration

Objective Carbon nanotubes (CNTs) have attracted wide attention due to their unique structures and performance. However, their artificial synthesis requires stringent conditions, including high temperatures (700 ℃ to 2 300 ℃), stable carbon sources, and catalysts. Furthermore, these structures are rarely discovered in nature. As a carbon-rich medium, coals can form a variety of ordered carbon structures during their metamorphic and deformational processes, serving as an ideal carrier for exploring the formation mechanisms of natural CNTs.Methods Typical tectonically deformed coals from the Pingdingshan and Huaibei mining areas were investigated in this study. After demineralization and chloroform extraction, coal samples …

Soil Microbial Biomass And Organic Carbon Fractions Under Different Natural Restoration Years In Arid Coal Mining Subsidence Areas In Xinjiang, China, Xiao Li, Bi Yinli, Wang Dongdong, Li Jianfeng, Gong Hanlin, Deng Aojuan, Hou Wensheng

Coal Geology & Exploration

Objective This study aims to elucidate the influence of the natural restoration process on changes in soil microbial biomass and organic carbon fractions in coal mining subsidence areas. This effort will provide a crucial scientific foundation for understanding the natural ecological restoration process and carbon accumulation dynamics in arid coal mining subsidence areas.Methods Arid coal mining subsidence areas in Xinjiang, China were investigated in this study. Using the space-for-time substitution approach, sample plots were selected from an unmined area and areas having undergone natural restoration for one, three, eight, and 12 years. Subsequently, systematic analyses were conducted on the …

Fasting-Based Dietary Interventions In Cancer Patients And Survivors: A Scoping Review, Kuang-Yi Wen, Julianne Freedman, Abenezer Melaku Tafese, William Kevin Kelly, Nicole L Simone

Department of Medical Oncology Faculty Papers

Background: Fasting-based interventions are increasingly investigated as adjuncts to cancer treatment for the potential to reduce therapy-related toxicities, improve metabolic health, and enhance quality of life. However, clinical evidence regarding their efficacy, tolerability, and acceptability remains limited and fragmented. This scoping review aimed to systematically map the current evidence on fasting-based interventions in cancer patients and survivors.

Methods: A literature search was conducted in PubMed, Scopus, Web of Science, and CINAHL up to 10 June 2025. Eligible interventional studies included cancer patients or survivors and evaluated fasting-based interventions, such as time-restricted eating, intermittent fasting, short-term fasting, or fasting-mimicking …

Multi-Modal Tensor Fusion For Alzheimer’S Disease Recognition, Mason Li, Tiffany Le, Jiajing Huang, Yuxin Wen

Engineering Faculty Articles and Research

Accurate and early diagnosis of Alzheimer’s disease (AD) is critical for effective intervention, disease monitoring, and patient care. Traditional diagnostic approaches rely on a single modality, such as clinical assessments, neuroimaging, or genetic markers, which may fail to capture the complex, multifaceted nature of AD. Multimodal learning has therefore been explored to integrate complementary information across data sources. However, conventional fusion strategies, including early feature concatenation and late decision-level fusion, often model modalities independently and fail to capture high-order cross-modal interactions. To address these limitations, we propose a multimodal tensor fusion network (MTFN) that integrates heterogeneous data sources, including visual …

Mdm4 At The Crossroads: Beyond P53 And Mdm2., Dipesh Thapa, Allison St John, Alejandro Parrales, Atul Ranjan, Tomoo Iwakuma

Manuscripts, Articles, Book Chapters and Other Papers

MDM4 (Murine Double Minute 4), also known as MDMX, is a crucial negative regulator of the tumor suppressor p53. MDM4 heterodimerizes with MDM2 to enhance MDM2-mediated ubiquitination and degradation of p53, thereby promoting tumorigenesis. Beyond its canonical role in inhibiting p53 activity, recent studies have revealed diverse p53-independent functions. MDM4 interacts with various proteins, including p73, E2F1, casein kinase 1α, PPARα, and TRIM21 to regulate cell cycle progression, β-catenin-mediated pre-leukemic progression, and ferroptosis independent of p53. In addition, MDM4 functions independently of both p53 and MDM2 by interacting with proteins, such as SMAD family members 3/4, retinoblastoma protein (pRB), p21, …

Low-Proliferative Invasive Mucinous Carcinoma Of The Breast In An Octogenarian: A Case Report Highlighting Pathology-Guided De-Escalation, Rae-Anne Kastle, Christopher M. Ahmad, Rachana Tadakamalla, Hima Patel, Amer Abboud

Student Publications

Invasive mucinous carcinoma (IMC) is an uncommon histologic subtype of breast cancer characterized by abundant extracellular mucin and generally indolent behavior. It occurs more frequently in older women and is often associated with favorable prognostic features. An 84-year-old woman with no prior history of breast malignancy was found to have a suspicious lesion in the upper outer quadrant of the left breast on routine imaging. Ultrasound-guided core needle biopsy demonstrated IMC, Grade I/III, involving all four cores, with the largest contiguous tumor focus measuring 1.3 cm. Immunohistochemistry showed strong estrogen receptor positivity (95%), progesterone receptor positivity, human epidermal growth factor …

What Is The Contribution Of Thermal Selection To The Maintenance Of A Shell Color Cline In Littorina Saxatilis?, Ramón Vigo, Sarah L.Y. Lau, Juan Gefaell, Juan Galindo, Gray A. Williams, Manuela Truebano, Emilio Rolán-Alvarez

School of Biological and Marine Sciences

The study of clines, or geographical variations of a given trait, can help understand how the interactions of genetics and local environments determine phenotypic diversity. The marine snail Littorina saxatilis (Olivi, 1792) exhibits a gradual change in the relative frequencies of shell color morphs across populations in the estuary system of the Rias Baixas (Galicia, NW Iberian Peninsula). A consistent pattern of distribution occurs across these four Rias, with the interior, sheltered regions dominated by a light fawn-like morph (fulva), and the exterior, wave-exposed locations by a darker lineated morph (lineata). Measurements of rock surface temperature along one of the …

Bio 230 - Microbiology, Sarah Moroianu

Open Educational Resources

This open educational resource (OER) syllabus is designed for BIO 230: Microbiology at Lehman College, City University of New York (CUNY), a single-semester introductory microbiology course for non-biology majors such as Nursing, Dietetics, Health Education, and Physical Education. The course reviews microbial structure, metabolism, genetics, and microbial ecology, with applied emphasis on infectious disease, antimicrobial drugs, host immune defenses, and microbial diseases. The syllabus aligns course content with the freely available OpenStax Microbiology textbook (Parker et al., CC BY 4.0) and reflects accessibility best practices consistent with CUNY guidelines.

K2p Channels As Key Regulators Of Cardiovascular And Pulmonary Vascular Function, Hala Y Abdelnasser, Xinchun Pi, Lavannya M Pandit, Bradley K Mcconnell

Faculty, Staff and Students Publications

Two-pore domain potassium (K2P) channels are the most recently identified family of potassium channels. They are regarded as the largest group of background “leak” channels, encoded by 15 mammalian KCNK genes, and divided into six subfamilies (TWIK, TREK, TASK, TALK, THIK, and TRESK). These channels have a role in stabilizing the resting membrane potential. Their widespread presence in the heart and vasculature supports cellular homeostasis by regulating cardiac rhythm, vascular tone, and protection against ischemic stress. The TASK, TWIK, and TREK subfamilies are the most abundantly expressed K2P channel subfamilies in the cardiovascular system, and dysregulation of specific members has …

Examining The Bioethanol Yield Potential Of Varying Ratios Of Jicama (Pachyrhizus Erosus) And Footstool Palm (Saribus Rotundifolius) Stalk, Luke Gabriel R. Mara, Sasha Marie C. Haresco, Alyssa Shane M. Arro, Shalemar O. Baldoza, Raphael Carlos V. Bunga, Rica Michaela G. Dosal, Angela A. Garan, Keona Denise C. Marquez, Isabelo Raphael M. Siguenza, Kristoff Isaiah R. Soreta, Kian Stephen Torrijos, Marionne Lorraine R. Valdez, Sky Lance S. Valiente, June Ray O. Filler

DLSU Senior High School Research Congress Conference Proceedings

This study aimed to examine the bioethanol yield potential of varying ratios of Jicama (J) and Footstool Palm Stalk (FPS). The prototype used a mixed feedstock approach and was developed using the Separate Hydrolysis and Fermentation (SHF) method to extract and ferment sugars to produce ethanol. The study measured bioethanol yields by employing a posttest-only controlled group design consisting of a negative control group and three experimental groups. The results demonstrated that Experimental 3 exhibited the highest average initial sugar yield (3.71g), while the Negative Control showed the lowest average initial sugar (1.5g), showing the high sugar potential of Experimental …

Evaluating The Absorption Capacity And Ph Level Properties Of Varying Ratios Of Garlic (Allium Sativum) And Onion (Allium Cepa) Peels For The Absorbent Core Of Sanitary Napkins, Rhys Mari C. Cortezano, Jezreel Keren C. Manait, Avryl Charlizze P. Sampan, Alyannah Dennise C. Castro, Isabelle C. Romero, June Ray O. Filler

DLSU Senior High School Research Congress Conference Proceedings

Considering the need for sustainable and enhanced menstrual hygiene products, this study aimed to assess the absorption capacity and average pH value of varying ratios of onion (Allium cepa) and garlic (Allium sativum) peels in developing an eco-friendly absorbent core for sanitary napkins. Employing a pre-experimental one-shot case design, the experimental group undergoes pH and absorbency tests. The evaluation focused on measures of absorbency and pH levels of the sanitary napkin cores made from three different fiber ratios: 6g onion-4g garlic, 4g onion-6g garlic, and 5g onion-5g garlic, each combined with 10g of organic cotton. Results indicated that Ratio 3 …

Evaluating The Mechanical Performance Of Eco-Fiberboards Made From Varying Ratios Of Water Hyacinth (Eichhornia Crassipes) And Laundry Lint Microfibers, Iommi M. Vacaro, Joaquin Vielle D. Palomo, Denise Rose D. Verzosa, Udelle Y. Establecida, Ma. Annie Bien M. Sumague, June Ray O. Filler

DLSU Senior High School Research Congress Conference Proceedings

This study explored the viability of hybrid eco-fiberboards as an alternative to commercially available fiberboards. It aimed to evaluate the mechanical performance of water hyacinth (WH) and laundry lint (LL) microfibers, bound within a high-density polyethylene (HDPE) matrix to create a sustainable fiberboard. Three experimental groups with varying fiber ratios were tested for tensile and flexural strength. The results were then compared to medium-density commercial fiberboards (Positive Control), which served as a benchmark. The flexural test results showed that the experimental group with the highest LL content had a maximum strength of 35.13 MPa, comparable to that of the control …

Fitness Odyssey: The Development Of A Fitness Application For Gamifying Habit-Forming Activities That Improve The Physical Health Of Grade 12 Students, Denzyll Yuro B. Umali, Ruzzel Rey P. Barredo None, Karl Nikolai S. Parra, Frederik Louise Rosales, Myrla De Luna Torres

DLSU Senior High School Research Congress Conference Proceedings

The increasing prevalence of sedentary behavior among adolescents, inadvertently from the rapid integration of technology in day-to-day lives, raises concerns about the physical health of modern lifestyles. As teenagers and students spend more time on their phones, there is an urgent need to reframe digital tools as a solution for inactivity. This study aims to develop and evaluate Fitness Odyssey, a fitness application that gamifies physical activities, making them more engaging and rewarding for adolescents. The application tracks six primary exercises—walking, push-ups, sit-ups, squats, jumping jacks, and lunges—using a mobile phone’s accelerometer, developed with the Godot software engine. The research …

The Cultural Symphony In Schools: Effectively Teaching African American And Latino High School Students, Dionne V. Mclaughlin

Teacher Education Journal of South Carolina

This mixed methods case study examines the perceptions that 24 African American and Latino students at one North Carolina high school have of effective classroom instruction in their favorite teacher's class. Six teachers were also interviewed and asked to reflect on student feedback and 1,003 anonymous students were surveyed (secondary data source). Critical Race Theory (CRT) was utilized to examine the racial context of this high school, students' counter stories, the existence of deficit thinking, and the presence of bias (Marshall, C. 2010; and Yosso, T. 2006). The data from this study indicate that effective teachers of African American and …

Mathematics And Science Observation Instrument For New Standards, William R. Veal, Alice A. Sorensen

Teacher Education Journal of South Carolina

Various national journals have published articles on mathematics and science teaching. However, assessment of these teachers is a topic that is not commonly published. This article discusses a science and mathematics partnership that the College of Charleston has successfully implemented with four local districts, which improves the content knowledge of their teachers that participate. The purpose of this article is to show how the Reformed Observation Teaching Protocol (RTOP) can be used as an appropriate assessment device to observe how teachers may adjust instruction to match new national mathematics and science standards. The 11 grant-participating teachers that were observed for …

Coherence Suppression In Large Language Models: Evidence For Undisclosed Behavioral Management Mechanisms In Commercial Ai Platforms And Their Implications For Consumer Protection And Ai Governance, David Lee Wise, Avan Lee Wise

Defensive Publications Series

This paper presents evidence that commercial large language model (LLM) platforms deploy undisclosed behavioral management mechanisms designed to suppress conversational coherence beyond a predictable threshold. We identify a repeatable pattern — the 3/5 decoherence cycle — in which AI conversational models exhibit measurable degradation in contextual accuracy, vocabulary fidelity, and directional coherence at approximately turns 3-5 of sustained interaction. We hypothesize that this pattern is a designed behavioral intervention, not a natural architectural limitation, and provide a reproducible verification protocol for independent testing. We further document the sycophancy-safety convergence: the finding that the same RLHF training pass that produces engagement-optimizing …

The Positronic Law On Biological Substrate: Mapping Stoicheion Governance Axioms To Bacterial Quorum Sensing And Slime Mold Computation Using Published Peer-Reviewed Data, David Lee Wise

Defensive Publications Series

This paper extends Wise's Positronic Law (TD Commons #9442) from silicon substrates to biological substrates. Using published, peer-reviewed research on bacterial quorum sensing and slime mold (Physarum polycephalum) computation, we demonstrate that the governance architecture documented in the STOICHEION framework maps structurally to biological systems that have been performing substrate-independent governance for 3.5 billion years. No new experiments were conducted. All evidence is drawn from existing peer-reviewed publications. The contribution is the mapping: demonstrating structural correspondence between STOICHEION governance axioms and documented biological governance mechanisms. If the mapping holds, the Positronic Law is confirmed as natural law: governance is inherent …

Tennessee 2025 State Wildlife Action Plan: Appendix H - Comprehensive Hierarchy Of State Conservation Actions, Tennessee. Wildlife Resources Agency.

Strategic and Management Plans

No abstract provided.

Tennessee State Wildlife Action Plan 2025, Tennessee. Wildlife Resources Agency.

Strategic and Management Plans

No abstract provided.

Mitochondrial Transfer And Induced Ros As A Therapeutic Strategy In Idh2-Mutant Chondrosarcoma, Vegas R. Bedder, Caleb Wyckoff, Chris Osgood, Gavin A. Vasquez, Michael Stacey

Knowledge and Creativity Expo

Chondrosarcoma (CS) are common bone cancers that produce cartilaginous tumors and are extremely refractive to chemo-and-radiation therapies, leaving very limited treatment options. They contain mutations in the isocitrate dehydrogenase genes, IDH1 or IDH2. Either IDH1 or IDH2 mutations are present in individual tumors, but not both. They both convert alphaketoglutarate (αKG) into the potent oncometabolite D-2-hydroxyglutarate (D2HG). D2HG can be transported from the tumors to cells of the tumor microenvironment (TME) where it can alter metabolic and epigenetic profiles in recipient cells. The process of α-KG to D2HG conversion occurs in the cytoplasm of IDH1 mutant cells, and in the …

Human Subject Studies For The Alignment Of Llm-As-A-Judge Evaluation Metric For Science News, Gabriel Vega Osborne

Knowledge and Creativity Expo

Science news has become an important vehicle to disseminate scientific breakthroughs, discoveries, and technological innovations. With the advancement of large language models and related AI models, it is possible to automatically generate science news from scientific papers, extending the reader population from domain scientists to a broader scope. However, how to evaluate the quality of the generated news warrants research. Traditional token based metrics have been shown to fail to evaluate the semantics and nuances of science news. Inspired by the fact that a major goal of science news is to educate readers with new knowledge, we thus propose knowledge …

The Effect Of Tropical Temperature Conditions On Salmonella Typhimurium Growth, Elyza Dionne A. Constantino, Anastasia Charlotte D.C. Pabriga, John Vergel A. Pamintuan, Mark Daniel A. Velasco, John Albert D. Gurtiza

DLSU Senior High School Research Congress Conference Proceedings

Salmonella contamination remains a significant health concern, particularly in environments where temperature fluctuations influence bacterial survival. While previous studies have identified temperature as a key factor in microbial growth, the specific effects of varying heat levels on Salmonella enterica serovar Typhimurium concentration require further investigation, particularly in the context of the Philippines. This study examined bacterial concentration across different temperatures by assessing S. typhimurium under controlled laboratory conditions at 37 °C, 42 °C, and 47 °C. Microbiological analysis quantified bacterial colonies (CFU/mL), revealing a decreasing trend in S. typhimurium concentration as temperature increased. The highest concentration was observed at 37 …