Digital Commons Network^™

Higher Dose Oral Fluconazole For The Treatment Of Aids-Related Cryptococcal Meningitis (Hiflac)--Report Of A5225, A Multicentre, Phase I/Ii, Two-Stage, Dose-Finding, Safety, Tolerability And Efficacy Randomised, Amphotericin B-Controlled Trial Of The Aids Clinical Trials Group, Umesh G. Lalloo, David B. Clifford, Et Al.

2020-Current year OA Pubs

BACKGROUND: The WHO recommended 1200mg/day of fluconazole (FCZ) in the induction phase of cryptococcal meningitis (CM) in HIV prior to 2018 in regions where amphotericin-B (AMB) was unavailable. A 2-stage AMB-controlled, dose-escalation study to determine the maximum tolerated dose and the safety/efficacy of an induction-consolidation strategy of higher doses FCZ (1200mg-2000mg/day), adjusted for weight and renal function (eGFR)in adults with CM was undertaken.

METHODS: In Stage-1, three induction doses of FCZ (1200mg/day, 1600mg/day and 2000mg/day) were tested in sequential cohortsand compared with AMB in a 3:1 ratio. A particular dose was not tested in Stage 2 if there were significant …

Small Molecule Inhibiting Microglial Nitric Oxide Release Could Become A Potential Treatment For Neuroinflammation, Philipp Jordan, Amanda Costa, Et Al.

2020-Current year OA Pubs

Microglia are the immune effector cells of the central nervous system (CNS) and react to pathologic events with a complex process including the release of nitric oxide (NO). NO is a free radical, which is toxic for all cells at high concentrations. To target an exaggerated NO release, we tested a library of 16 544 chemical compounds for their effect on lipopolysaccharide (LPS)-induced NO release in cell line and primary neonatal microglia. We identified a compound (C1) which significantly reduced NO release in a dose-dependent manner, with a low IC50 (252 nM) and no toxic side effects in vitro or …

The Circular Rna Landscape In Multiple Sclerosis: Disease-Specific Associated Variants And Exon Methylation Shape Circular Rna Expression Profile, Giulia Cardamone, Elvezia Maria Paraboschi, Giulia Soldà, Giuseppe Liberatore, Valeria Rimoldi, Javier Cibella, Federica Airi, Veronica Tisato, Claudia Cantoni, Francesca Gallia, Donato Gemmati, Laura Piccio, Stefano Duga, Eduardo Nobile-Orazio, Rosanna Asselta

2020-Current year OA Pubs

BACKGROUND: Circular RNAs (circRNAs) are a class of non-coding RNAs increasingly emerging as crucial actors in the pathogenesis of human diseases, including autoimmune and neurological disorders as multiple sclerosis (MS). Despite several efforts, the mechanisms regulating circRNAs expression are still largely unknown and the circRNA profile and regulation in MS-relevant cell models has not been completely investigated. In this work, we aimed at exploring the global landscape of circRNA expression in MS patients, also evaluating a possible correlation with their genetic and epigenetic background.

METHODS: We performed RNA-seq experiments on circRNA-enriched samples, derived from peripheral blood mononuclear cells (PBMCs) of …

Sex-Related Differences In Premature Cardiovascular Disease In Familial Hypercholesterolemia, Anandita Agarwala, Elena Deych, Laney K Jones, Amy C Sturm, Karen Aspry, Zahid Ahmad, Christie M Ballantyne, Anne C Goldberg

2020-Current year OA Pubs

BACKGROUND: Familial hypercholesterolemia (FH) is associated with an increased prevalence of premature atherosclerotic cardiovascular disease (ASCVD), however, little is known about sex-specific differences in premature ASCVD and its risk factors.

OBJECTIVE: The present study seeks to assess the burden and risk factors for premature ASCVD among men and women with FH.

METHODS: In this study we retrospectively examined sex-specific differences in ASCVD prevalence, risk factor burdens, and lipid treatment outcomes in 782 individuals with clinically or genetically confirmed FH treated in 5 U.S. lipid and genetics clinics. A generalized linear model using Binomial distribution with random study site effect and …

The Neurotoxin Dsp-4 Dysregulates The Locus Coeruleus-Norepinephrine System And Recapitulates Molecular And Behavioral Aspects Of Prodromal Neurodegenerative Disease, Alexa F. Iannitelli, Michael A. Kelberman, Daniel J. Lustberg, Anu Korukonda, Katharine E. Mccann, Bernard Mulvey, Arielle Segal, L Cameron Liles, Steven A. Sloan, Joseph D. Dougherty, David Weinshenker

2020-Current year OA Pubs

The noradrenergic locus coeruleus (LC) is among the earliest sites of tau and α-synuclein pathology in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively. The onset of these pathologies coincides with loss of noradrenergic fibers in LC target regions and the emergence of prodromal symptoms including sleep disturbances and anxiety. Paradoxically, these prodromal symptoms are indicative of a noradrenergic hyperactivity phenotype, rather than the predicted loss of norepinephrine (NE) transmission following LC damage, suggesting the engagement of complex compensatory mechanisms. Because current therapeutic efforts are targeting early disease, interest in the LC has grown, and it is critical to identify …

On Doing Justice, Loving Mercy, And Walking Humbly In Micah 6:8: The Peaceable Ways Of Israel's God, Then And Now, Paul N. Anderson

Faculty Publications - George Fox School of Theology

Despite YHWH's presentation in the Hebrew Scripture as, at times, a warrior, a divine portrait also emerges of a God of justice, mercy, and lovingkindness, rooted in God's steadfast love (hesed) and desire for peaceable wholeness (salom)....This essay will explore the justice of lsrael's God, peace and prosperity as components of God's shalomic blessing, the turbulence of lsrael's eighth-century situation, and the prophets' creative calls for repentance--highlighting God's peaceable ways--relevant both then and now.

D. Elton Trueblood: Dean Of American Religious Writing, Paul N. Anderson

Faculty Publications - George Fox School of Theology

It is with great delight that HarperCollins has given the Trueblood family permission to republish any of Elton Trueblood's books that they should choose. Harpers had published thirty of his books between 1936 and 197 4, and Elton's momentous volumes earned him the title of "Dean of American Religious Writing" in the middle-to-late 20th century. I had already edited and published his book on Lincoln under a new title, with a new foreword by award-winning journalist Gustav Niebuhr, timed to coincide with the Lincoln movie that came out in 2012. 1 Elton's most important book, A Place to Stand, then …

"Foreword" To A Place To Stand, Paul N. Anderson

Faculty Publications - George Fox School of Theology

Known as "the Dean of American Religious Writing," D. Elton Trueblood did for American audiences something similar to what C.S. Lewis achieved in Britain. He helped believers em­ brace their faith and to give an account for the hope that is with­ in them (I Peter 3: 15). Author of thirty-one books, followed by a half-dozen collections of his essays, Trueblood also encouraged generations of other emerging writers so that his influence was multiplied many times over. Addressing such issues as the vitali­zation of the church and the equipping of the laity for ministry, he did more to inspire "thinking …

Effective Teachers Of Multilingual Learners: A Mixed-Method Study Of Uk And Us Critical Sociocultural Teaching Practices, Naomi Flynn, Annela Teemant, Kara Mitchell Viesca, Ratha Perumal

Department of Teaching, Learning, and Teacher Education: Faculty Publications

This convergent parallel mixed-method study (quan + QUAL) relies on systematic classroom observations of mainstream teachers considered highly effective with multilingual learners in the United Kingdom and the United States (N = 9). Using a critical sociocultural theoretical lens, we use an established quantitative observation rubric and lesson field notes to capture real-world teaching practices. Using deductive reasoning to merge closed- and open-ended observation data, we illuminate the features of highly effective teaching for multilingual students. Evidence demonstrates that elements of challenge in activity design and teacher presentation, prioritizing language and literacy development, and modeling, were practices with the highest …

“It Was Just My Name!”: A Crt/Crf Analysis Of International Female Graduate Students’ Perceptions And Experiences Regarding Their Ethnic Name, Peiwen Wang, Xiaoyan Gu, Amanda Morales

Department of Teaching, Learning, and Teacher Education: Faculty Publications

Although international female students accounted for 44% of the enrolled international students in the United States (U.S. Department of Homeland Security’s Student and Exchange Visitor Information System, 2020), their experiences regarding their ethnic name are relatively understudied in the onomastic literature. This study considers the experiences of eight international female graduate students of Color who are studying at a Midwestern predominantly White university. Utilizing critical race theory (CRT) and critical race feminism (CRF) as the theoretical and analytical lenses, this qualitative phenomenological study collected data through semistructured, in-depth interviews. We explore the meaning of ethnic names and their connection to …

“It’S Like They Don’T Recognize What I Bring To The Classroom”: African Immigrant Youths’ Multilingual And Multicultural Navigation In United States Schools, Lydiah Kananu Kiramba, Alex Kumi-Yeboah, Anthony Mawuli Sallar

Department of Teaching, Learning, and Teacher Education: Faculty Publications

Discourses of African immigrant children are rare in educational research. As such, African immigrant educational experiences are often obscured (in part, owing to the model minority myth about Africans based on higher education degrees received by African immigrants), as well as the actual experiences and realities for African immigrant K-12 students. This qualitative study examines cross-cultural educational experiences of 30 Black African immigrant youth in U.S. schools. The findings reveal multiple participants’ struggles with cultural and linguistic differences, stereotypes and marginalization in the school environment, low expectations from teachers, and adjusting to new schooling practices. The African youths’ voices exhibited …

“Just Attaching A Face”: Engaging Local Refugee Communities In Preservice Teacher Education Focused On Students With Immigrant/Refugee Backgrounds, Stephanie Wessels, Theresa Catalano, Jenelle Reeves, Alison E. Leonard, Uma Ganesan, Alessia Barbici-Wagner, Consuelo Gallardo

Department of Teaching, Learning, and Teacher Education: Faculty Publications

This arts-practice research study explores what happens when preservice high school teachers (aka teacher-learners) and local refugee communities engage in the co-creation of art together via an arts-and community-based project. Grounded in social justice teacher education, the researchers conducted a 2-week workshop in which participants included preservice high school teachers and local Yazidi community members who explored art in a museum together, spent time getting to know each other and their backgrounds, and re-created some of their stories in the form of dance. Findings reveal a variety of ways in which the workshops helped teacher-learners develop interculturality, increase understanding of …

Prevalence Of Bourbon And Heartland Viruses In Field Collected Ticks At An Environmental Field Station In St. Louis County, Missouri, Usa, Ishmael D. Aziati, Derek Mcfarland Jr., Avan Antia, Astha Joshi, Anahi Aviles-Gamboa, Preston Lee, Houda Harastani, David Wang, Solny A. Adalsteinsson, Adrianus C M Boon

2020-Current year OA Pubs

Heartland and Bourbon viruses are pathogenic tick-borne viruses putatively transmitted by Amblyomma americanum, an abundant tick species in Missouri. To assess the prevalence of these viruses in ticks, we collected 2778 ticks from eight sampling sites at Tyson Research Center, an environmental field station within St. Louis County and close to the City of St. Louis, from May - July in 2019 and 2021. Ticks were pooled according to life stage and sex, grouped by year and sampling site to create 355 pools and screened by RT-qPCR for Bourbon and Heartland viruses. Overall, 14 (3.9%) and 27 (7.6%) of the …

Efficacy Of Laser Interstitial Thermal Therapy For Biopsy-Proven Radiation Necrosis In Radiographically Recurrent Brain Metastases, Michael Chan, Albert H Kim, Eric Leuthardt, Et Al.

2020-Current year OA Pubs

BACKGROUND: Laser interstitial thermal therapy (LITT) in the setting of post-SRS radiation necrosis (RN) for patients with brain metastases has growing evidence for efficacy. However, questions remain regarding hospitalization, local control, symptom control, and concurrent use of therapies.

METHODS: Demographics, intraprocedural data, safety, Karnofsky performance status (KPS), and survival data were prospectively collected and then analyzed on patients who consented between 2016-2020 and who were undergoing LITT for biopsy-proven RN at one of 14 US centers. Data were monitored for accuracy. Statistical analysis included individual variable summaries, multivariable Fine and Gray analysis, and Kaplan-Meier estimated survival.

RESULTS: Ninety patients met …

Combating Compassion Fatigue In The Emergency Department, Pam Packard

Doctor of Nursing Practice Projects

Combating compassion fatigue in the emergency department is vital to nurses’ well-being. Compassion fatigue is the result of negative physical, emotional, and spiritual strains that often burden nurses. The weight of compassion fatigue is explored throughout this conceptualization of Combating Compassion Fatigue. Two questions were explored: Does compassion fatigue affect compassion satisfaction? If so, is compassion fatigue a precursor to suboptimal compassion satisfaction?

Heart Smart Holidays: Coping With Stress, Staying Active, And Healthy Cooking Strategies For Seniors In Cleveland County, Lauren Ridgeway

Doctor of Nursing Practice Projects

This Doctor of Nursing Practice Project assessed whether attending community group meetings focusing on stress, staying active, and healthy eating during the holidays, could influence cardiovascular disease awareness, mental health awareness, and quality of life of senior citizens in Cleveland County. A convenience sample of 6 participants attended the Coping with Stress and Staying Active event while 10 participants attended the Healthy Cooking Strategies event. The objectives were measured using a pretest posttest design before and after the presentations. There was strong evidence (t(9) = -13.597, p < .05) that the group seminar on managing stress and staying active during the holiday season improved the mental health awareness of participants. Data also showed a significant increase in Cardiovascular Disease Awareness from pretest to posttest (t(5) = 3.246, p < .05) after the seminar on healthy cooking strategies. The project raised community awareness to the importance of managing stress, staying active, and making small nutritional changes to positively impact the cardiovascular health of Seniors.

Health Utilities And Quality-Adjusted Life Years For Patients With Amyotrophic Lateral Sclerosis Receiving Reldesemtiv Or Placebo In Fortitude-Als, Paulos Gebrehiwet, Lisa Meng, Stacy A Rudnicki, Phil Sarocco, Jenny Wei, Andrew A Wolff, Michael Butzner, Adriano Chiò, Jinsy A Andrews, Angela Genge, Dyfrig A Hughes, Carlayne E Jackson, Noah Lechtzin, Timothy M Miller, Jeremy M Shefner

2020-Current year OA Pubs

AIMS: To estimate the health utilities and quality-adjusted life years (QALYs) in patients with amyotrophic lateral sclerosis (ALS) receiving

MATERIALS AND METHODS: We performed a post hoc analysis of clinical trial data from FORTITUDE-ALS (NCT03160898). This Phase IIb, double-blind, randomized, dose-ranging, placebo-controlled, parallel-group, 12-week trial evaluated

RESULTS: The full analysis set consisted of 456 patients (

CONCLUSIONS: This post hoc analysis of FORTITUDE-ALS suggests that

CLINICALTRIALS.GOV IDENTIFIER: NCT03160898.

Exploring Spectral Bias In Time Series Long Sequence Forecasting, Kofi Nketia Ackaah-Gyasi, Sergio Valdez, Yifeng Gao, Li Zhang

Computer Science Faculty Publications

Transformers have achieved great success in the task of time series long sequence forecasting (TLSF) in recent years. However, existing research has pointed out that over-parameterized deep learning models are in favor of low frequency and could be difficult to capture high-frequency information for regression fitting task, named spectral bias. Yet the effect of such bias on TLSF problem, an auto-regressive problem with a long forecasting length, has not been explored. In this work, we take the first step to investigate the spectral bias issues in TLSF task for state-of-the-art models. Specifically, we carefully examine three different existing time series …

Challenges And Prospects Of Library And Information Services In Academic Libraries In Nigeria, Josiah Chukwumaobi Nworie, Elvis Uchenna Ubochi, Charity Iwuchukwu, Chioma Chinyere Njoku

Library Philosophy and Practice (e-journal)

Every activity that is being done and carried out in the library is aimed at delivering services to the users and the community that is hosting the library. The services that libraries render cannot be overemphasized especially the Academic library. Their advantages are numerous and help towards the growth and development of the society. Libraries have continued to evolve since its operation, and the emergence of Information and Communication Technologies (ICTs) has changed alot about librarianship all over the world. Many new concepts are being introduced, yet, not without their challenges and prospects. No academic library is devoid of challenges; …

Human Resource Development Practices In Academic Libraries In Tertiary Institutions In Nigeria, Cajetan Okechukwu Onyeneke, Doris Chiemeka Obasi

Library Philosophy and Practice (e-journal)

This study examined human resource development practices in academic libraries in non-university tertiary institutions in Imo State, Nigeria. Four research questions and four hypotheses guided the study. A descriptive survey design was used for the study. A census study technique was adopted to cover the entire population of one hundred and fifty-two (152) library staff in the four public tertiary institutions in Imo State. A rating scale titled “Human Resource Development Practices Rating Scale (HRDPRS) was used to collect data for the study. A reliability index was established using Pearson Product Moment Correlation (PPMC) and it was (r) 0.82. The …

Application Of Icts In Federal University Lokoja Library, Ayooluwa Aregbesola, Juliet Omale, Dauda Yahaya

Library Philosophy and Practice (e-journal)

This research study, application of ICT in newly Established Federal University Library in Nigeria; a case study of Federal University Lokoja. The research was guided by five research questions. Survey research method was used and questionnaire was the instrument for data collection. Mean scores where used to analyze the data generated. From the analyzed data, it was discovered that ICTs are averagely applicable though it has enormously benefited some library services in Federal University Lokoja, Library. The challenges identified were inadequate ICT facilities, Epileptic power supply and poor network facilities. In consonant with the vision of Federal University Lokoja Library, …

Attitude, Perception And Practice Towards Pleasure Reading Among University Students: A Case Study, Md. Sakib Biswas

Library Philosophy and Practice (e-journal)

This study investigates the attitudes, perceptions and practices of pleasure reading among the undergraduate and graduate students of Dhaka University. Undergraduate and Graduate students under three major faculties i.e. Arts and Social Sciences; Business Studies; and Science, Engineering & Technology have been selected to participate in this survey. A total of 300 questionnaires have been distributed among the interested participants and the libraries of the concerned faculties were selected for selecting respondents randomly. Systematic random sampling method has been deployed for the convenient of the study. Data analysis has been done using SPSS Version 25 and MS Excel. The study …

Effective Use Of Medical Library: A Qualitative Approach To Quality Medical Care., Oluchi Cecilia Okeke Dr., Ngozi Fidelia Enem Dr.

Library Philosophy and Practice (e-journal)

The library is always known to be the warehouse of resources in terms of books and non-book materials. This paper generally discussed the medical library which is a library that is found or situated in any health related establishment, as well as the resources and services obtainable from it. It also emphasized on the need to provide varied information services and ICTs resources in the delivery of qualitative Medicare to clients of these libraries. The paper also stressed why medical libraries should be used effectively thereby giving that qualitative approach to quality Medical care services to her clients.

University And College Profiles Available On Indian Research Information Network System (Irins): A Comparative Study, Prabhat Ranjan, Bhupendra Kumar Singh

Library Philosophy and Practice (e-journal)

Indian Research Information Network System (IRINS) is a research information management system that provides details of publications and citations by researchers in academic and research institutes in India. It is an undisputed fact that the productivity of researchers is not uniform within and beyond institutions. A quantitative study was formulated to compare the productivity of researchers within and between categories of central university, state university, deemed university, private university, and college. The coefficient of variation (C.V.) and coefficient of range (C.R.) was measured to know about dispersions among data of publications, patents, Scopus citations, and Crossref citations. It was found …

Staff Training Indices For Effective Library Services In Donald E.U. Ekong Library, University Of Port Harcourt, Rivers State, Nigeria., Nkiruka Blessing Wali, Jeremiah Emeka Ugwulebo

Library Philosophy and Practice (e-journal)

The study was designed to examine the staff training indices for effective library services in Donald E. U. Ekong Library, University of Port Harcourt, Rivers State, Nigeria. The indices in the study relates to the challenges and strategies to enhance staff training in the library. The study was guided by three objectives and research questions respectively. Descriptive survey research design was adopted for the study. The population for this study was 104 staff comprising both professional and para-professional staff of the library. Data was collected using questionnaire and analysed using mean scores. Findings of the study revealed that key staff …

Disaster Risk Reduction Management Practices: The Case Of A Private Academic Library In Northern Philippines, Rico Bautista Orenia, David A. Cabonero

Library Philosophy and Practice (e-journal)

This study aimed to determine the possible causes of library disasters, disaster practices, and challenges of Saint Mary's University Learning Resource Center (SMULRC) on prevention, preparedness, response, and recovery. The respondents were the nine librarians of SMULRC. It made use of mixed methods of research. A quantitative design was used to identify the possible causes of disasters and determine the frequency and percentage of librarians practicing disaster risk reduction management. The qualitative method was used to support the quantitative answers and to know the challenges they experienced in disaster management. The study found that: 1) natural disasters such as storm …

Status Of Blended Library Services At The University Of Baguio, Lea C. Colbongan-Papay, Jackson Bacolong Colas

Library Philosophy and Practice (e-journal)

Blended library services are reinforced by academic librarians to deal with the challenges that come from the changes caused by the pandemic. Transformation is reflected through information and communication technologies that are in constant development and available to users remotely. This study discusses the extent of usage and effectiveness of blended library services at the University of Baguio library by the students, faculty, non-teaching, and other library users. Blended library services covered online platforms, online resources, online circulation, online reference service, online information literacy (IL), and online want list form. This study used a descriptive research design to gather the …

Prison Libraries, Intellectual Freedom And Social Justice In Nigeria, Olusegun Adebayo Opesanwo, Oluyomi Abidemi Awofeso Phd

Library Philosophy and Practice (e-journal)

This paper deployed a systematic review to examine prison libraries and intellectual freedom towards attaining social justice in Nigeria. Information resources used cover the periods of 2010 and 2020 to articulate the necessary development in prison libraries, intellectual freedom and social justice in Nigeria. Search engines such as Google scholar, Semantic Scholar, and RefSeek were used to retrieve information and through different queries yielded several results but very few of them were selected to fit in the study due to limited studies directed to address the focus of this study particularly in the Nigeria scenario. Information obtained were subjected to …

Oriental Research Institute & Manuscripts Library, Kerala: A Case Study, Sarita Somarajan, S Mohammed Esmail Dr

Library Philosophy and Practice (e-journal)

The Oriental Research Institute & Manuscripts Library, University of Kerala, houses the treasures of ancient knowledge in India. It has come in to existence out of royal interest. The kings of Travancore, as a rule, were valorous as well as lovers of art and literature. Srimulam Thirunal was mainly responsible for the spread of Oriental literature throughout the world. It was he who instituted the department for the publication of manuscripts which in due course grew into the present institution. It is located at Kariavattom, Thiruvananthapuram, Kerala. Its origin goes back to the illustrious Maharaja of Travancore, Swati Tirunal (1829-1846). …

Exploring The Benefits Of Library Consortium: The Information Resource Sharing., Muhammad Bala Kasim, Fati Abba, Hajara Jibril, Yahaya Abdullahi Isah, Aliyu Muhammad Babadoko

Library Philosophy and Practice (e-journal)

This paper examines the cardinal benefits of library consortium which is the resource sharing. Resource sharing aims at maximizing collection and services of libraries and information centres at minimum cost. Various sources of information (primary and secondary literature) were perused to view the essentiality of resource sharing in carrying out effective and efficient library and information services to users. The paper also highlighted the requirements needed for successful resource sharing practices among libraries. The significance/benefits of resource sharing as it relates to economic, developmental, academic/research as well as social life of librarians and library personnel were clearly stated. An ideal …