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Articles 90781 - 90810 of 91566
Full-Text Articles in Entire DC Network
Relationships Between Geochemistry, Carbon Content, And Grain Size In Clastic Cave Sediments, Rebekah Rose Nicholas
Relationships Between Geochemistry, Carbon Content, And Grain Size In Clastic Cave Sediments, Rebekah Rose Nicholas
Graduate Theses, Dissertations, and Problem Reports (ETD)
Understanding geochemical and physical properties of cave sediment gives insight to sediment characterization and carbon storage in the cave system. Previous work on clastic sediments largely encompasses physical properties, neglecting the importance of geochemical parameters on sediment deposition.
This study reports physical and chemical properties of sediment cores from three caves: two caves in Puerto Rico and one cave in Virginia. A total of 25 cores were used in this study; 6 of these cores were new and collected in 2022 from Butler Cave (BTC) in Virginia to focus on the effects of water level. Core samples were analyzed for …
The Percussionist's Guide To Music Theory Fundamentals, Mckenna M. Lee
The Percussionist's Guide To Music Theory Fundamentals, Mckenna M. Lee
Graduate Theses, Dissertations, and Problem Reports (ETD)
The research priorities that I have established as a theorist, percussionist, and an instructor of both, have led me to a master's thesis project combining music theory practices within the study and performance of percussion repertoire. As the graduate assistant of the percussion department at West Virginia University, I have been teaching applied orchestral percussion lessons and leading percussion ensembles. In my experience, a number of first-year percussionists in the studio at WVU have had a limited background with reading definite pitches on the staff, and struggle with sight-reading and pitch identification, therefore making their Written I and Aural I …
Single Field Of View Calibration Through Estimating Three Mutually Orthogonal Vanishing Points For Spatial Data Collection In Traffic Scenes, Sourav Dutta
Graduate Theses, Dissertations, and Problem Reports (ETD)
Accurately extracting the three mutually orthogonal vanishing points plays a vital role in the field of view calibration for many surveillance-based traffic applications. However, the paucity of parallel lines along the dominant directions in many traffic scenes engenders the inapplicability of the current methods for a successful calibration. This research proposed a novel vanishing point estimating method for traffic scenes. This method capitalizes on both the road scene and moving vehicles for the determination of the dominant directions of the real-world coordinate frame. It also exploits distinctive edgelets for the direct identification of vanishing point candidates. Both lab and field …
Application Of Computational Biophysics Techniques To Characterize Cell Membrane-Associated Events, Kyle Billings
Application Of Computational Biophysics Techniques To Characterize Cell Membrane-Associated Events, Kyle Billings
Graduate Theses, Dissertations, and Problem Reports (ETD)
Cell membranes are crowded environments which can modulate protein structure-function relationships through interaction with lipids, other proteins, carbohydrate structures and so on. This work focuses the impact of the membrane environment on two varieties of peptides: Microbial rhodopsin proteins, and cyclic peptides.
Life on Earth is dependent on the ability of plants and microbes to harness sunlight for energy production. Their ability to transform light into carbohydrates requires tailor-made machinery, and for a wealth of microorganisms, microbial rhodopsin proteins (MR) are critical for maintaining the concentration gradients used to produce the energy molecule Adenosine triphosphate (ATP). The central retinal molecule …
Studies On Depth And Torsion In Tensor Products Of Modules, Uyen Huyen Thao Le
Studies On Depth And Torsion In Tensor Products Of Modules, Uyen Huyen Thao Le
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation represents an in-depth exploration of two distinct yet interconnected research topics within commutative algebra: one centered around a conjecture of Huneke and R. Wiegand and the other concerns a depth inequality of Auslander. It consists of the following three papers as well as the author's work under the direction of Professor Olgur Celikbas:
- Remarks on a conjecture of Huneke and Wiegand and the vanishing of (co)homology, Journal of Mathematical Society of Japan Advance Publication. (joint work with Olgur Celikbas, Hiroki Matsui, and Arash Sadeghi).
- An extension of a depth inequality of Auslander, Taiwanese Journal of Mathematics, …
Improving The Health And Safety Of Manufacturing Workers By Detecting And Addressing Personal Protective Equipment (Ppe) Violations In Real-Time With The Use Of Automated Ppe Detection Technology, Joseph Olufemi Fasinu
Improving The Health And Safety Of Manufacturing Workers By Detecting And Addressing Personal Protective Equipment (Ppe) Violations In Real-Time With The Use Of Automated Ppe Detection Technology, Joseph Olufemi Fasinu
Graduate Theses, Dissertations, and Problem Reports (ETD)
The Centers for Disease Control and Prevention (CDC) emphasized that Personal Protective Equipment (PPE) can significantly reduce the risk of occupational injuries and illnesses. However, improper use, failure to use, and other PPE-related violations can still result in injuries and fatalities. Eye and face protection violation has been one of the top 10 most frequently violated OSHA standards in fiscal years 2018, 2019, 2020, 2021 and 2022 consecutively. A common practice among safety professionals to ensure PPE compliance has been to physically inspect or monitor PPE usage among workers, which has been found to be unsustainable on a continuous real-time …
Factors Influencing High School Physical Education Teachers' Content Selection, Olivia J. Gillispie
Factors Influencing High School Physical Education Teachers' Content Selection, Olivia J. Gillispie
Graduate Theses, Dissertations, and Problem Reports (ETD)
There is limited research that has examined the factors that influence the selection of content for high school physical education. Addressing this gap in the literature is important, as those decisions influence student attitudes and engagement in physical education. The purpose of this study is twofold. First, this study aimed to explore what factors influence high school physical education teachers’ decision-making processes when selecting content to include in their curriculum (phase one). Second, this study investigated the facilitators and barriers to selecting and teaching the content areas suggested in the SHAPE America (2013) High School Grade-Level Outcomes (phase two).
This …
Social Determinants Of Health And Functional Disability At Mid- And Late-Life, Carly Pullen
Social Determinants Of Health And Functional Disability At Mid- And Late-Life, Carly Pullen
Graduate Theses, Dissertations, and Problem Reports (ETD)
The number and proportion of older adults living in the U.S. and globally are increasing. Not only are more adults living longer (Rania et al., 2021), there is evidence that people are
entering late life with more functional disability than in previous generations (He & Larsen,
2014). Social determinants of health include demographic and environmental influences than can impact a range of health outcomes beyond more direct risk factors (Duran and Perez-Stable, 2019). Using data from 243,693 community-dwelling adults who completed the 2020 Behavioral Risk Factor Surveillance System survey, we tested the associations among social determinants of health (i.e., age, …
Ambush, Reprisal, Riot, Revolt, And Reform: The Transnational Evolution Of British Colonial Policing In Ireland And The Palestine Mandate, 1918-1948, Tyler Kickler Krahe
Ambush, Reprisal, Riot, Revolt, And Reform: The Transnational Evolution Of British Colonial Policing In Ireland And The Palestine Mandate, 1918-1948, Tyler Kickler Krahe
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation looks at the changes in British colonial policing between Ireland and the Palestine Mandate from 1918 and 1948. This time period covers the duration of the Anglo-Irish War, as well as Britain’s mandatory control of Palestine. It is the argument of this work that from 1918 to 1936, between Ireland and the Palestine Mandate, British colonial police forces demonstrated a pattern of evolving police training, practice, and organization, spurred on by violent action and followed by attempts at reform. This pattern continued until the Arab Revolt of 1936 when the police forces in the Palestine Mandate abandoned attempts …
Career Progression And Experiences Of Late Career Women Strength And Conditioning Coaches, Marla Df Gladstone
Career Progression And Experiences Of Late Career Women Strength And Conditioning Coaches, Marla Df Gladstone
Graduate Theses, Dissertations, and Problem Reports (ETD)
Women in strength and conditioning roles at the NCAA Division I level account for approximately 16% of the S&C coaching professionals (NCAA, 2022). Between 2000 and 2022, only six studies have examined the population of female strength and conditioning coaches (SCC). The aim of this project was to understand the challenges women SCC have experienced reaching, entering, and sustaining to late career. Another goal was to learn how women SCC navigated through the barriers within the coaching profession. Due to the construction of gender in organizations, role congruity theory has been used to analyze the experiences of women in sport …
Motion Planning In Artificial And Natural Vector Fields, Bernardo Martinez Rocamora Junior
Motion Planning In Artificial And Natural Vector Fields, Bernardo Martinez Rocamora Junior
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation advances the field of autonomous vehicle motion planning in various challenging environments, ranging from flows and planetary atmospheres to cluttered real-world scenarios. By addressing the challenge of navigating environmental flows, this work introduces the Flow-Aware Fast Marching Tree algorithm (FlowFMT*). This algorithm optimizes motion planning for unmanned vehicles, such as UAVs and AUVs, navigating in tridimensional static flows. By considering reachability constraints caused by vehicle and flow dynamics, flow-aware neighborhood sets are found and used to reduce the number of calls to the cost function. The method computes feasible and optimal trajectories from start to goal in challenging …
Understanding The Impact Of Scientific Testimony On Potential Jury Members: Independent And Interactive Effects Of Expert Characteristics And Jury Member’S Social Location, Ellory R. Dabbs
Graduate Theses, Dissertations, and Problem Reports (ETD)
As science and technology evolve, they impact society at different levels. With these changes, it is important to understand how members of society will be affected. One area where there has been a rise in the use of scientific information is in jury trials. Those who are on trial for a criminal offense are more often relying on forensic evidence, and forensic experts, to aid in their defense, and those who are prosecuting a criminal case are also relying on forensic evidence and forensic experts. However, forensic evidence is not consistent in type or interpretation – what one person may …
Effects Of Ethanol And Nicotine Co-Administration On Risky Choice In Rats, Erin E. Wylie
Effects Of Ethanol And Nicotine Co-Administration On Risky Choice In Rats, Erin E. Wylie
Graduate Theses, Dissertations, and Problem Reports (ETD)
Individuals often engage in the comorbid use of alcohol (ethanol) and nicotine, leading to further-escalated health consequences than the use of either drug in isolation. Given the poor health outcomes resulting from the combined administration of ethanol and nicotine, some of which may be due to increased risky choice, more basic research is needed to better characterize drug/dose interactions on risky choice. Probability-discounting procedures involve a series of discrete choices between a smaller, certain reinforcer (i.e., a safer choice) and a larger, increasingly uncertain reinforcer (i.e., a riskier choice). Probability-discounting procedures allow for the assessment of …
Evaluating The Effects Of Modifying Mixing And Pelleting Parameters On Feed Quality, Pellet Production Rate, And Broiler Performance, Lucas E. Knarr
Evaluating The Effects Of Modifying Mixing And Pelleting Parameters On Feed Quality, Pellet Production Rate, And Broiler Performance, Lucas E. Knarr
Graduate Theses, Dissertations, and Problem Reports (ETD)
In Chapter 2, an experiment was conducted to evaluate the effect of different mixer types (MTY) and mix times (MTI) on mix uniformity (MU). A 2 (mix time) x 3 (mixer type) factorial was utilized in this experiment to create six treatments, each mixed in three randomized complete blocks. Mix times were designated adequate or inadequate, were based on the manufacturers’ recommendation, and varied based on the mixer utilized. The mixer types utilized included a vertical mixer, horizontal mixer, and transfer mixing system. The transfer mixing system can be described as a batch-to-mix system …
Three Essays On Political Economy, Colin Michael Steitz
Three Essays On Political Economy, Colin Michael Steitz
Graduate Theses, Dissertations, and Problem Reports (ETD)
The first chapter studies the impact of conventions and multi-day events on
hotel demand in the Indianapolis metro area. Using hand-collected data on
sporting events and conventions, we study the impact on hotel metrics: ADR,
Occupancy, Daily Rate, and Revenue. We show that traditional sporting
events generate little impact when compared to multi-day conventions. We
show that mega-events such as major championship games generate significant
increases in hotel demand. We find large and statistically significant effects for
multi-day conventions on hotel demand with very little evidence of crowding
out. A single day of a multi-day convention brings in approximately $928,000 …
Effects Of Light/Dark Cycle Shifts On Delay Discounting, Katya A. Nolder
Effects Of Light/Dark Cycle Shifts On Delay Discounting, Katya A. Nolder
Graduate Theses, Dissertations, and Problem Reports (ETD)
Shift-work conditions are a necessity for the constant provision of certain medical, industrial, and commercial services in modern society. Shift work is associated with the increased risk of many negative health outcomes, including type 2 diabetes, heart disease, reproductive issues, and cancer. Shift workers experience multiple levels of circadian-rhythm disruption, which may increase maladaptive decision making, and this may mediate the relation between shift work and negative health outcomes. Circadian-rhythm disruptions can be systematically investigated in the basic laboratory, and one type of procedure involves changing the light/dark cycle in the animal vivarium. The current study investigated effects of light/dark …
Fast Raising: Digital Fundraising As Interaction Rituals, Matthew P. Hartwell
Fast Raising: Digital Fundraising As Interaction Rituals, Matthew P. Hartwell
Graduate Theses, Dissertations, and Problem Reports (ETD)
Twice a year, GamesDoneQuick hosts events that showcase the Speed Running Community, a sub-set of the Video Game Community. Since its inception in 2014 through 2021 GDQ has raised $25.7 million that has been distributed to the Prevent Cancer Foundation and Médecins Sans Frontiers (Doctors without Borders). This collection of studies analyzes the Awesome Games Done Quick 2020 event utilizing the Interaction Ritual Theory framework of Randall Collins to understand how ritualistic social action of this community has been leveraged by event organizers to promote successful crowd funding efforts that benefits organizations outside of the community. Further it expands on …
Footwear Image Quality Classification: Using Subjective Assessments And Objective Image Metrics To Predict Impression Quality, En-Tni Lin
Graduate Theses, Dissertations, and Problem Reports (ETD)
Shoeprints deposited during the commission of a crime vary in quality as a function of numerous factors, such as substrates, media, and the specific physical activities carried out by perpetrators. This variability in impression quality impacts the amount of information available from questioned crime scene impressions, and therefore an examiner's confidence in providing opinions of source attribution. In response, this research attempted to characterize footwear impression quality based on image sharpness, contrast, entropy, homogeneity, noise, quantity of information, and complexity, and to integrate these hand-engineered feature descriptions with subjective opinions of impression quality.
The methodology followed a five-pronged approach. First, …
“I’Ll Tell You No Lies”: An Exploration Of Trauma, Memory, And Violence Against Women In North Carolina Murder Ballads, Madison Ava Helman
“I’Ll Tell You No Lies”: An Exploration Of Trauma, Memory, And Violence Against Women In North Carolina Murder Ballads, Madison Ava Helman
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation explores trauma, memory and violence against women in Western North Carolina murder ballads “Tom Dooley,” “Poor Omie Wise,” “Poor Ellen Smith,” “The Ballad of the Lawson Family,” and “Frankie Silver.” I posit that these ballads were influenced by prescriptive societal conceptions of femininity, which in turn influenced societal ideations of violence against women. Using folklore performance theory, I analyze the text and context of these ballads and their subsequent histories, eventually arriving at a template for polyvocality that incorporates multiple ballad variants and encourages diverse performances.
Probabilistic Short Term Solar Driver Forecasting With Neural Network Ensembles, Joshua Daniell
Probabilistic Short Term Solar Driver Forecasting With Neural Network Ensembles, Joshua Daniell
Graduate Theses, Dissertations, and Problem Reports (ETD)
Commonly utilized space weather indices and proxies drive predictive models for thermosphere density, directly impacting objects in low-Earth orbit (LEO) by influencing atmospheric drag forces. A set of solar proxies and indices (drivers), F10.7, S10.7, M10.7, and Y10.7, are created from a mixture of ground based radio observations and satellite instrument data. These solar drivers represent heating in various levels of the thermosphere and are used as inputs by the JB2008 empirical thermosphere density model. The United States Air Force (USAF) operational High Accuracy Satellite Drag Model (HASDM) relies on JB2008, and …
Evaluation Of Changes In Cellular Behavior Upon Exposure To Selected Analytes Used In Synthetic Applications, Olivia L. Rose
Evaluation Of Changes In Cellular Behavior Upon Exposure To Selected Analytes Used In Synthetic Applications, Olivia L. Rose
Graduate Theses, Dissertations, and Problem Reports (ETD)
Metal-organic frameworks (MOFs) are organic crystalline hybrids that have been used for a variety of applications from catalysis to gas storage and drug delivery. Studies have shown that generally, while such frameworks are more biocompatible than similar aspect ratio nanostructures, they are also more prone to transformation and disintegration due to their flexible and fragile nature as resulted from the structure assembly and implemented structure-function relationships. With extensive previous literature showing that materials with nano dimensions such as carbon nanotubes, quantum dots and other nanomaterials have unique physicochemical properties that lead to increased biosystems’ reactivity. With increasing concerns regarding adverse …
Leveraging Data Science To Promote Sustainable Resource Recovery From Organic Waste Streams In Rural Regions, Mohammed Tamim Zaki
Leveraging Data Science To Promote Sustainable Resource Recovery From Organic Waste Streams In Rural Regions, Mohammed Tamim Zaki
Graduate Theses, Dissertations, and Problem Reports (ETD)
Conventional organic waste management practices such as landfilling contribute to global warming and degrade environmental and human health. Alternatively, organic waste can be treated to recover energy, nutrients, and carbon through resource recovery technologies. Data science could benefit such technologies by improving their efficiency through data-driven process modeling along with reducing environmental and economic burdens via life cycle assessment (LCA) and techno-economic analysis (TEA), respectively.
A critical review of 616 peer-reviewed articles published during 2002–2022 was conducted on the use of data science methods in resource recovery from organic waste. Although applications of machine learning (ML) methods have drastically increased …
“Ingenious Entanglements”: Sheriffs, Capitalism, And Civil Society In America, 1750-1850, Chad R. Holmes
“Ingenious Entanglements”: Sheriffs, Capitalism, And Civil Society In America, 1750-1850, Chad R. Holmes
Graduate Theses, Dissertations, and Problem Reports (ETD)
Sheriffs served as indispensable legal actors who facilitated the expansion of democracy and capitalist transformation, processes that eventually limited their ability to profit from their work and diminished their social status. This dissertation is organized around specific sheriffs and the actions they performed to illustrate how county officers influenced society beyond the execution of court orders. These men—Rhode Island’s Beriah Brown, Pennsylvania’s John Barker, and Massachusetts’s Elisha Porter, Luke Baldwin, and Charles P. Sumner—believed they understood how to balance community demands and state directives in ways that would produce personal profit and greater authority. The work of these officers and …
Effects Of Oxycodone And Methylphenidate On Self-Control With Aversive Outcomes, Jeremy Saul Langford
Effects Of Oxycodone And Methylphenidate On Self-Control With Aversive Outcomes, Jeremy Saul Langford
Graduate Theses, Dissertations, and Problem Reports (ETD)
In the context of choice, one is said to show self-control under numerous conditions in which consideration is given to the delayed outcomes of each option. This can be difficult: both reinforcing and aversive outcomes become less effective as they are increasingly delayed. Several socially significant issues arise from a failure of delayed, aversive outcomes to impact choice, especially when immediate, reinforcing outcomes are available. Identifying the conditions under which choice is sensitive to delayed outcomes is critical to shifting choices toward alternatives in which contact with delayed, aversive outcomes is minimized. Two experiments were conducted with the aim of …
Microwave-Assisted Ammonia Synthesis Over Cs-Ru/Ceo2 Catalyst, Alazar Kesete Araia
Microwave-Assisted Ammonia Synthesis Over Cs-Ru/Ceo2 Catalyst, Alazar Kesete Araia
Graduate Theses, Dissertations, and Problem Reports (ETD)
Ammonia synthesis is one of the greatest innovations of the 20th century with extensive applications from fertilizers to intermediates for nitrogen-containing chemicals and pharmaceuticals. Annually, more than 242 million tons of ammonia is produced globally, supporting approximately 27% of the world’s population. One of the fast-growing applications for ammonia is as H2 energy carrier due to its high energy storage capacity, considered to be a decarbonized energy source. The low volumetric energy density and incompressibility makes Hydrogen a non-preferable energy carrier; an alternative carrier becomes a requirement. Ammonia possesses unique property as an energy-dense carrier to store and …
Cue Reactivity In Non-Smoking Electronic Cigarette Users, Ashley E. Douglas
Cue Reactivity In Non-Smoking Electronic Cigarette Users, Ashley E. Douglas
Graduate Theses, Dissertations, and Problem Reports (ETD)
Electronic cigarettes (ECIGs) are among the most popular nicotine products in the United States, particularly among youth and young adults. Many individuals who use ECIGs report an interest in quitting or unsuccessful quit attempts. In addition to nicotine dependence, one factor that may contribute to continued ECIG use is an individual’s response to ECIG-related environmental stimuli, or cues. Existing research demonstrates that exposure to ECIG cues increases craving for ECIGs among cigarette smokers, including those without previous ECIG experience. The purpose of this study was to examine effects of ECIG cue exposure in experienced ECIG users with minimal smoking history, …
Right Treatment Wrong Time: Immunotherapy Administration Post-Radiotherapy Decreases Tumor Burden In A Preclinical Model Of Brain Metastasis, Kathryn Elizabeth Blethen
Right Treatment Wrong Time: Immunotherapy Administration Post-Radiotherapy Decreases Tumor Burden In A Preclinical Model Of Brain Metastasis, Kathryn Elizabeth Blethen
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation (a) provided an in-depth literature review of methods to modulate the blood-brain and blood-tumor barriers to increase drug delivery and efficacy in brain metastases, (b) evaluated the effects of whole-brain radiation therapy on the blood-brain barrier in immunocompetent and immunocompromised mouse models and proposed a mechanism by which the immune response to radiation disrupts the blood-brain barrier, and (c) developed a syngeneic lung cancer brain metastasis model to determine the impact of coordinated immunotherapy administration with radiotherapy. The blood-brain barrier is an impediment to drug delivery to the brain. The inherent leakiness of the blood-tumor barrier does not …
Glial Cell-Specific Contribution Of Pkr-Like Er Kinase (Perk) In Neuroinflammation And Behavior, Anirudhya Lahiri
Glial Cell-Specific Contribution Of Pkr-Like Er Kinase (Perk) In Neuroinflammation And Behavior, Anirudhya Lahiri
Graduate Theses, Dissertations, and Problem Reports (ETD)
Neurological disorders such as multiple sclerosis (MS) are a major public health concern in the US, with no available therapeutic cure. Chronic neuroinflammation and aberrant proteostasis in the central nervous system (CNS) are the major hallmarks of neurological diseases. Endoplasmic Reticulum (ER) is a major cellular organelle involved in protein synthesis, folding and maturation of various secretory and transmembrane proteins. Pathophysiological stressors such as trauma and infection result in misfolded protein accumulation in the endoplasmic reticulum (ER) lumen, which results in ER stress. To regain proteostasis (protein homeostasis), cells activate the unfolded protein response (UPR). UPR is an evolutionarily conserved …
Evaluate A Mixer Of Hydrogen Peroxide And Peroxyacetic Acid To Mitigate Microbial Cross-Contamination Of Salmonella Typhimurium And The Surrogate Enterococcus Faecium During Triple-Washing Of Butternut Squash, Jesica M. Temple
Graduate Theses, Dissertations, and Problem Reports (ETD)
Background: Recent foodborne illness outbreaks have been linked to fresh fruits and vegetables. For public safety, awareness of the risks of contamination from foodborne pathogens that can occur during post-harvest farming practices is essential to prevent foodborne outbreaks. Controlling the spread of foodborne pathogens on produce requires proper washing procedures, antimicrobials and doses. Given the speed and diversity of the produce being distributed, local incidents may become international emergencies. Methods: Studies were included if they assessed the efficacy of antimicrobials and various washing procedures and had to conclude the mitigation of cross-contamination of foodborne pathogens on produce grown in the …
Role Of Ca2+ In Healthy And Pathologic Cardiac Function: From Normal Excitation–Contraction Coupling To Mutations That Cause Inherited Arrhythmia, Joshua A Keefe, Oliver M Moore, Kevin S Ho, Xander H T Wehrens
Role Of Ca2+ In Healthy And Pathologic Cardiac Function: From Normal Excitation–Contraction Coupling To Mutations That Cause Inherited Arrhythmia, Joshua A Keefe, Oliver M Moore, Kevin S Ho, Xander H T Wehrens
Faculty, Staff and Students Publications
Calcium (Ca2+) ions are a key second messenger involved in the rhythmic excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca2+-handling proteins is required for healthy cardiac function, whereas disruption in any of these can cause cardiac arrhythmias. This comprehensive review provides a broad overview of the roles of Ca2+-handling proteins and their regulators in healthy cardiac function and the mechanisms by which mutations in these proteins contribute to inherited arrhythmias. Major Ca2+ channels and Ca2+-sensitive regulatory proteins involved in cardiac excitation–contraction coupling are discussed, with special emphasis on the function of the RyR2 macromolecular complex. Inherited …