Digital Commons Network^™

Leptin Decreases Gluconeogenesis And Gluconeogenic Substrate Availability In Patients With Lipodystrophy, Emmanuel Quaye, Shaji Chacko, Megan Startzell, Rebecca J Brown

Children’s Nutrition Research Center Staff Publications

Context: The effects of leptin, an adipocyte-derived hormone that signals overall energy sufficiency, can only be studied in leptin-deficient conditions. In patients with lipodystrophy, a rare disease and unique model of leptin deficiency, treatment with recombinant leptin (metreleptin) improves glycemia and decreases energy expenditure. We hypothesized that these improvements might be mediated by reduced gluconeogenesis (GNG), an energy-requiring process.

Objective: To determine the effects of metreleptin on GNG and GNG substrates.

Methods: This was a single-arm prospective study of metreleptin administration in 15 patients with lipodystrophy, 9 of whom had data on GNG (NIH, 2013-2018). We analyzed total GNG, insulin-mediated …

Harnessing The Power Of Student Voice: A Case Study Of Hybrid Proficiency-Based And Co-Created Curriculum And Assessment, Kaitlyn A. Seamons

Theses and Dissertations

Assessment has become a dirty word in arts education, because art is notoriously difficult to assess. Assessment, which is often disliked or even disavowed by arts educators, due to its history of incompatibility with the idiosyncratic nature of arts learning, should ideally be utilized as a means of measuring student progress and help teachers understand how to help students succeed. While assessment can also be used to evaluate programs and teachers and to compare student successes relative to those of other students, I will be focusing on measuring individual student progress for my thesis and building a curriculum to support …

Playing To Grow. Roundtable Interview On Games, Education, And Character, Owen Gottlieb, Matthew Farber, Paul Darvasi

Articles

In this roundtable interview moderated by Paul Darvasi, lecturer at the University of Toronto and co-founder of Gold Bug Interactive, Owen Gottlieb and Matthew Farber discuss research and practice at the intersection of religion, character education, and games in schools. Gottlieb is an associate professor at the Rochester Institute of Technology, founder and lead faculty at the Initiative in Religion, Culture, and Policy at the MAGIC center, and founder and director of the Interaction, Media, and Learning Lab at RIT, where he specializes in interactive media, learning, religion, and culture. Farber is an associate professor of educational technology and coordinator …

Parallel Neural Pathways Control Sodium Consumption And Taste Valence, Yameng Zhang, Allan-Hermann Pool, Tongtong Wang, Lu Liu, Elin Kang, Bei Zhang, Liang Ding, Kirsten Frieda, Richard Palmiter, Yuki Oka

Faculty, Staff and Student Publications

The hedonic value of salt fundamentally changes depending on the internal state. High concentrations of salt induce innate aversion under sated states, whereas such aversive stimuli transform into appetitive ones under sodium depletion. Neural mechanisms underlying this state-dependent salt valence switch are poorly understood. Using transcriptomics state-to-cell-type mapping and neural manipulations, we show that positive and negative valences of salt are controlled by anatomically distinct neural circuits in the mammalian brain. The hindbrain interoceptive circuit regulates sodium-specific appetitive drive , whereas behavioral tolerance of aversive salts is encoded by a dedicated class of neurons in the forebrain lamina terminalis (LT) …

Assessment Of Deficits In Specific Cognitive Domains In Older Adults Living With Hiv., Andrea Reyes-Vega, Harideep Samanapally, Rishikesh Rijal, Stephen P. Furmanek, Christopher B. Shields, Brandon C. Dennis, Smita Ghare, Shirish Barve

Faculty and Staff Scholarship

A significant proportion of people living with HIV (PLWH) have cognitive impairment. Moreover, approximately 70% of PLWH in the United States will be ≥50 years old by 2030, raising concerns of a higher incidence of dementia as they age. Accordingly, there is a clinical need to monitor their cognitive status. The aim of this study was to delineate specific cognition areas impacted in OALWH with a clinical diagnosis of neurocognitive impairment. We used a comprehensive set of tests (paper and NIH Toolbox Cognition Battery), to assess different cognitive domains in a total of 25 OALWH ≥ 50 years. 64% were …

Technology Justice: Taxation Of Our Collective And Cumulative Cognitive Inheritance, Hilary G. Escajeda

Loyola of Los Angeles Law Review

As artificial intelligence and robotic technologies accelerate economic transformation, outdated property and tax laws will increasingly fail American workers with ordinary skills that perform routine job functions. Because technology may render millions of workers redundant, U.S. policymakers must make significant social, economic, and legal structural changes to (1) improve the lives of average workers, (2) support the economy, and (3) maintain political stability.

Inspired by Thomas Paine’s Agrarian Justice, this twenty-first century Article argues that “Technology Justice” requires that humans benefit from the cognitive endowment created by our ancestors’ minds. Specifically, it asserts that our collective and cumulative cognitive …

A More Capacious Conception Of Church, Samuel D. Brunson, Philip T. Hackney

Loyola of Los Angeles Law Review

No abstract provided.

Strings Are Attached: Shining A Spotlight On The Hidden Subsidy For Perpetual Donor Limits On Gifts, Roger Colinvaux

Loyola of Los Angeles Law Review

Charitable gifts often come with strings attached. Donors limit their gifts in many ways, typically by restricting an asset’s use or purpose, the timing of spending (as in an endowment), and by securing naming rights. Donors also limit their gifts by giving to a charitable intermediary such as a donor-advised fund or private foundation, thereby retaining effective control over the distribution or investment of the donated asset. Donor limits are perpetual in nature. This Article assesses the law of donor limits. The Article explains that non-tax legal rules strongly favor donor limits; they are easy for donors to impose and …

Protecting America’S Favorite Pastime: An Analysis Of Match-Fixing Laws In States With Legal Sports Gambling, Alyssa Telles Wyatt

Loyola of Los Angeles Law Review

In 2018, the Supreme Court overturned the longstanding prohibition against sports betting in Murphy v. NAACP. States rushed to capitalize on the new industry, with twenty-eight states currently regulating sports betting. These new laws primarily focus on licensure requirements and generally fail to protect sports’ integrity through match-fixing prohibitions. While a few federal laws regulate sports gambling, only one specifically addresses match-fixing. Against this background, this Note analyzes and compares states’ sports gambling laws against their match-fixing laws, and it proposes new legislation aimed at protecting the integrity of sports games.

Cárcel De Amor / The Prison Of Love, Laura Francis, Álvaro Garrote Pascual

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

Introduction To The Special Issue On Artificial Intelligence In Counselor Education And Supervision, Russell Fulmer, Wendell Callahan, Olivia Uwamahoro Williams

Journal of Technology in Counselor Education and Supervision

No abstract provided.

Counseling And Artificial Intelligence: Forging A Path Forward (Commentary), Russell Fulmer

Journal of Technology in Counselor Education and Supervision

The thesis of this editorial is twofold. First, counselors should work with Artificial Intelligence (AI), and AI should work with counseling. Second, counselors should increase their involvement with, essentially, all things AI. Counseling should forge a path forward with artificial intelligence. This editorial is a bit premature for pragmatists. Where is artificial intelligence (AI) in mental health? The answer is seemingly a paradox, everywhere yet nowhere. Everywhere, through AI subfields like machine learning, natural language processing applications, chatbots, and the myriad ways that large language models find correlations in data hidden from the human eye. Also, AI is nowhere to …

Using Ai-Supported Supervision In A University Telemental Health Training Clinic, Donna Sheperis, Shiri Sadeh-Sharvit

Journal of Technology in Counselor Education and Supervision

Artificial Intelligence (AI) technologies have the potential of transforming clinical education and supervision in university-based telemental health training clinics. AI can improve the accuracy of diagnoses, automate routine tasks, and personalize treatment plans, potentially enhancing the accessibility and quality of mental health care. In this paper, we describe why training clinics serve as an optimal setting to adopt innovation and share lessons from the field to inform future integrations of AI in clinical supervision. The lessons include support for case conceptualization, feedback on session quality, and automation of routine tasks such as sending standardized assessments and writing progress notes. However, …

Artificial Intelligence, Virtual Reality, And Augmented Reality In Counseling: Distinctions, Evidence, And Research Considerations, Sidney Shaw, Sophie Oswin, Yue Xi, Fallon Calandriello, Russell Fulmer

Journal of Technology in Counselor Education and Supervision

Technology is experiencing a growing presence in counseling and mental health, attracting attention from counselors, researchers, and the general public. This growth has the potential to change counseling practice, counselor education, and how users access mental health services. In this article we provide definitions of and distinctions between three common technologies that are used in the counseling field—Artificial Intelligence, Virtual Reality, and Augmented Reality. We also provide examples of the use of each technology, ethical implications, research support, and recommendations for future research.

Artificial Intelligence For Mental Health Support During Covid-19: Experiences Of Graduate Counseling Students, Russell Fulmer, Eric T. Beeson, Carl Sheperis, Daniel Rosello, Rebecca Edelman

Journal of Technology in Counselor Education and Supervision

The purpose of this study was to examine how an AI chatbot could provide mental health support to counselors-in-training during the COVID-19 pandemic. The chatbot “Tess” was available to participants for two weeks. Participants responded to questions about their experience and the content of this qualitative data was analyzed. Themes emerged that focused on mental health during the pandemic, utility of the AI chatbot during the pandemic, and potential therapeutic use in general. Findings were mixed and suggest some skepticism among counseling students towards the use of an AI chatbot.

Towards Ethical Artificial Intelligence In Universities: Chatgpt, Culture, And Mental Health Stigmas In Asian Higher Education Post Covid-19, Michael James Day

Journal of Technology in Counselor Education and Supervision

Mental health can be interpreted as a social taboo in Asia, ensuring that students with mental health stigmas (SWMHS) face complex educational journeys that impact their wellbeing. This article provides a conceptual interdisciplinary commentary that illustrates how in Asian higher education (HE) settings, the psychosocial phenomena of face culture, a sociolinguistic blend of high-context power relations, sense-making, and cultural capital, defines human-to-human (HTH) dialogue. It suggests that human-to-computer-interaction (HCI) through artificial intelligence (AI) technologies, such as ChatGPT, could improve university wellbeing strategies in Asia. The article situates AI discussion into the sociolinguistic features of face culture in Thailand and China …

Simvastatin In Critically Ill Patients With Covid-19, Thomas E Hills, Elizabeth Lorenzi, Lindsay R Berry, Murali Shyamsundar, Farah Al-Beidh, Djillali Annane, Yaseen Arabi, Diptesh Aryal, Carly Au, Abigail Beane, Zahra Bhimani, Marc Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Aidan Burrell, Meredith Buxton, Carolyn S Calfee, Maurizio Cecconi, Allen C Cheng, Matthew E Cove, Michelle A Detry, Lise J Estcourt, Mark Fitzgerald, Ewan C Goligher, Herman Goossens, Cameron Green, Rashan Haniffa, David A Harrison, Madiha Hashmi, Alisa M Higgins, Christopher Horvat, David T Huang, Nao Ichihara, Deva Jayakumar, Peter S Kruger, François Lamontagne, Lamprini Lampro, Patrick R Lawler, John C Marshall, Alexina J Mason, Anna Mcglothlin, Shay Mcguinness, Zoe K Mcquilten, Bryan J Mcverry, Paul R Mouncey, Srinivas Murthy, Matthew D Neal, Alistair D Nichol, Cecilia M O'Kane, Rachael L Parke, Jane C Parker, Ebenezer Rabindrarajan, Luis F Reyes, Kathryn M Rowan, Hiroki Saito, Marlene Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Pratik Sinha, B Taylor Thompson, Alexis F Turgeon, Anne M Turner, Frank Van De Veerdonk, Sebastian Weis, Ian S Young, Ryan Zarychanski, Roger J Lewis, Colin J Mcarthur, Derek C Angus, Scott M Berry, Lennie P G Derde, Steve A Webb, Anthony C Gordon, Daniel F Mcauley

Faculty, Staff and Student Publications

BACKGROUND: The efficacy of simvastatin in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.

METHODS: In an ongoing international, multifactorial, adaptive platform, randomized, controlled trial, we evaluated simvastatin (80 mg daily) as compared with no statin (control) in critically ill patients with Covid-19 who were not receiving statins at baseline. The primary outcome was respiratory and cardiovascular organ support-free days, assessed on an ordinal scale combining in-hospital death (assigned a value of -1) and days free of organ support through day 21 in survivors; the analyis used a Bayesian hierarchical ordinal model. The adaptive design included prespecified statistical …

Risk Sensitivity Analysis Of Ais Cyber Security Through Maritime Cyber Regulatory Frameworks, Omer Soner, Gizem Kayisoglu, Pelin Bolat, Kimberly Tam

School of Engineering, Computing and Mathematics

Given the increasing frequency and sophistication of methods and strategies employed in cyberattacks, cyber resilience has become a basic notion of cyber risk management. To be cyber-resilient against cyber risks, shipping companies must be proactive in establishing and implementing actions, constructing effective strategies, and adopting mitigation methods to strengthen their assets. However, shipping companies have only lately tended to fully recognize the necessity for a cybersecurity perspective to enable effective cyber risk management and mitigation of increasing cyberattacks. Aside from deficiencies in system design, integration, or maintenance, human factors are the prime weakness that potentially jeopardizes the ship's cybersecurity by …

Missing The Point- The Disappointed Hope Of Self- Publishing Authors, Simone Schroff

School of Law, Humanities and Social Sciences

Trade book publishing is characterised by authors with weaker bargaining power than the commercial intermediaries, including publishers and distributors. One key solution representing the empowerment of authors is self-publishing works, thereby cutting out the gatekeeper. However, self-publication has failed to improve the position of authors: their incomes continue to fall across the sector. Using social network analysis as well as industry practices, this article examines UK trade book publishing dynamics. It argues that the reason for the self-publication route’s ‘underperformance’ is structural, explained by a realistic view of the publishing sector and the relationships it entails. The self- publishing author …

Mcpeek V. Dny2 153 Norfolk St. Llc

All Decisions

No abstract provided.

The Involvement Of Hepatic Cytochrome P450s In The Cytotoxicity Of Lapatinib, Si Chen, Xilin Li, Yuxi Li, Xiaobo He, Matthew Bryant, Xuan Qin, Feng Li, Ji-Eun Seo, Xiaoqing Guo, Nan Mei, Lei Guo

Faculty, Staff and Students Publications

Lapatinib, an oral tyrosine kinase inhibitor used as a first-line treatment for HER2-positive breast cancer, has been reported to be associated with hepatotoxicity; however, the underlying mechanisms remain unclear. In this study, we report that lapatinib causes cytotoxicity in multiple types of hepatic cells, including primary human hepatocytes, HepaRG cells, and HepG2 cells. A 24-h treatment with lapatinib induced cell cycle disturbances, apoptosis, and DNA damage, and decreased the protein levels of topoisomerase in HepG2 cells. We investigated the role of cytochrome P450 (CYP)-mediated metabolism in lapatinib-induced cytotoxicity using our previously established HepG2 cell lines, which express each of 14 …

Metagenomic Analysis Unveils The Microbial Landscape Of Pancreatic Tumors, Sheema Khan, Goutam Banerjee, Saini Setua, Daleniece Jones, Bhavin Chauhan, Anupam Dhasmana, Pratik Banerjee, Murali M. Yallapu, Stephen Behrman, Subhash C. Chuahan

School of Medicine Publications

The composition of resident microbes in the human body is linked to various diseases and their treatment outcomes. Although studies have identified pancreatic ductal adenocarcinoma (PDAC)-associated bacterial communities in the oral and gut samples, herein, we hypothesize that the prevalence of microbiota in pancreatic tumor tissues is different as compared with their matched adjacent, histologically normal appearing tissues, and these microbial molecular signatures can be highly useful for PDAC diagnosis/prognosis. In this study, we performed comparative profiling of bacterial populations in pancreatic tumors and their respective adjacent normal tissues using 16S rRNA-based metagenomics analysis. This study revealed a higher abundance …

Dsm-5 Conduct Disorder And Symptoms In Youths At High Risk Of Psychosis In Kenya With Dsm-5 Mental Disorders And Substance Use: Towards Integrated Management, David M Ndetei, Victoria Mutiso, Christine Musyimi, Reinpeter Momanyi, Pascalyne Nyamai, Peter Tyrer, Daniel Mamah

2020-Current year OA Pubs

Little is known about the prevalence of Conduct Disorder (CD) and symptoms of CD in high risk psychosis persons at both clinical and community populations in LMICs and in particular Kenya. This study aimed to document (1) the prevalence of CD diagnosis and symptoms in youth who screened positive for psychosis and (2) the associated mental disorders and substance use in the same cohort in LMIC. The sample size was 536 students who had screened positive on the Washington Early Recognition Center Affectivity and Psychosis (WERCAP) from a population of 9,742 high school, college and university students, but had not …

Consistent Across Situations? A Person Specific Approach To Examining A Long-Standing Paradox., Muchen Xi

Arts & Sciences Graduate Student Theses and Dissertations

Bem and Allen (1974) address the person situation debate by proposing that there are some people behave more consistently, which can be better “explained” try personality traits, than others who are more influenced by situations. However, with failures to directly replicate Bem and Allen’s study, the existence of individual difference in cross situation consistency of behaviors remaining unclear. The current study addressed open questions that arose from the personality consistency debate by employing Mixed Effect Location Scale Model (MELSM) in an intensive longitudinal study. We found 1) there are individual difference in the overall behavioral consistency across situations; 2) there …

Characterizing The Relationship Between Accented Speech Intelligibility And Listening Effort, Mel Mallard

Arts & Sciences Graduate Student Theses and Dissertations

Unfamiliar accents can make speech communication difficult, both by reducing speech intelligibility and by increasing the effort listeners must put forth to understand speech. However, these two constructs, while related, are independent: for example, two 100% intelligible utterances may require different amounts of effort to accurately process. To better characterize the relationship between intelligibility and effort, this study presents speakers of four intelligibility levels (one natively-accented English speaker, and three Mandarin-accented English speakers) within a dual-task paradigm (featuring a vibrotactile secondary task) to measure listening effort. We found a negative nonlinear relationship between intelligibility and effort, with the steepest slope …

Comparative Analysis Of Rectum Delineation: Inter-Observer Agreement Among Treatment Planners Versus Auto Segmentation In A Single Institution, Haley Douglas

Masters Projects

Abstract

Introduction

The past 20 years have seen a continuous rise in the cancer patient population, resulting in staffing shortages, longer wait times for patients, and potentially lower-quality care. Artificial intelligence has been incorporated into the healthcare system and has provided ease with understaffing. Using AI technology to delineate structures can reduce planning time and variation between planners. The objective of this research is to assess the level of consistency in the rectum boundary delineation performed by different dosimetrists working at a single institution, as compared to the performance of the AutoContour software. This analysis will help determine the efficacy …

An Autoethnography Journey: Social And Emotional Learning In A Post-Covid Classroom, April Edwards

Masters Theses (Archived)

In this autoethnography journey, we explore the question, "What resources are available for teachers to use to guide SEL instruction, and how effective are those resources post-pandemic?" Post-COVID-19 pandemic, we noticed that our students needed more social interaction time in the classroom. Student behaviors increased alongside teacher frustration. Districts immediately began to see this struggle in the school systems and the growing concern from parents and teachers. Our children were not taught how to respectfully express their social and emotional needs due to the lack of opportunity to practice with others. During this study, we found that teachers …

Ints6 And The Integrator Phosphatase Module Tune The Efficiency Of Select Premature Transcription Termination Events, Rina Fujiwara, Si-Nan Zhai, Dongming Liang, Aayushi P Shah, Matthew Tracey, Xu-Kai Ma, Christopher J Fields, María Saraí Mendoza-Figueroa, Michele C Meline, Deirdre C Tatomer, Li Yang, Jeremy E Wilusz

Children’s Nutrition Research Center Staff Publications

The metazoan-specific Integrator complex catalyzes 3' end processing of small nuclear RNAs (snRNAs) and premature termination that attenuates the transcription of many protein-coding genes. Integrator has RNA endonuclease and protein phosphatase activities, but it remains unclear if both are required for complex function. Here, we show IntS6 (Integrator subunit 6) over-expression blocks Integrator function at a subset of Drosophila protein-coding genes, although having no effect on snRNAs or attenuation of other loci. Over-expressed IntS6 titrates protein phosphatase 2A (PP2A) subunits, thereby only affecting gene loci where phosphatase activity is necessary for Integrator function. IntS6 functions analogous to a PP2A regulatory …

You Can Lead A Horse To Water: Mapping Seasonal Water Resources To Predict Wild Horse Movements On Utah Rangelands, David C. Stoner, Eric Thacker, Linden Greenhalgh, Mark Nelson

All Current Publications

All wild horse herd management areas in Utah overlap BLM grazing allotments. Although horses and cattle have similar dietary habits, both species rely heavily on predictable water sources during dry periods. The concentration of wildlife and livestock in mesic areas during droughts can become problems for farmers and livestock producers. We aimed to map the annual distribution of temporary surface water across Utah that cattle, horses, and wildlife could use. Herein we analyzed an 18-year record of satellite imagery to create a statewide map of seasonal surface-water availability for agricultural and wildlife management purposes.

Harm Reduction In Undergraduate And Graduate Medical Education: A Systematic Scoping Review, Kelsey R. Smith, Nina K. Shah, Abby L. Adamczyk, Lara C. Weinstein, Erin L. Kelly

Department of Family & Community Medicine Faculty Papers

BACKGROUND: Substance use increasingly contributes to early morbidity and mortality, which necessitates greater preparation of the healthcare workforce to mitigate its harm. The purpose of this systematic scoping review is to: 1) review published curricula on harm reduction for substance use implemented by undergraduate (UME) and graduate medical education (GME) in the United States and Canada, 2) develop a framework to describe a comprehensive approach to harm reduction medical education, and 3) propose additional content topics for future consideration.

METHODS: PubMed, Scopus, ERIC: Education Resources Information Center (Ovid), and MedEdPORTAL were searched. Studies included any English language curricula about harm …