Digital Commons Network^™

Distinct Gene Expression Signatures Comparing Latent Tuberculosis Infection With Different Routes Of Bacillus Calmette-Guérin Vaccination, Richard F Silver, Mei Xia, Chad E Storer, Jessica R Jarvela, Michelle C Moyer, Azra Blazevic, David A Stoeckel, Erin K Rakey, Jan M Tennant, Johannes B Goll, Richard D Head, Daniel F Hoft

2020-Current year OA Pubs

Tuberculosis remains an international health threat partly because of limited protection from pulmonary tuberculosis provided by standard intradermal vaccination with Bacillus of Calmette and Guérin (BCG); this may reflect the inability of intradermal vaccination to optimally induce pulmonary immunity. In contrast, respiratory Mycobacterium tuberculosis infection usually results in the immune-mediated bacillary containment of latent tuberculosis infection (LTBI). Here we present RNA-Seq-based assessments of systemic and pulmonary immune cells from LTBI participants and recipients of intradermal and oral BCG. LTBI individuals uniquely display ongoing immune activation and robust CD4 T cell recall responses in blood and lung. Intradermal BCG is associated …

Pharmacokinetics Of Dacarbazine And Unesbulin And Cyp1a2-Mediated Drug Interactions In Patients With Leiomyosarcoma, Lan Gao, Diksha Kaushik, Brian A Van Tine, Matthew A Ingham, Steven Attia, Christian F Meyer, Gary K Schwartz, Pius Maliakal, John D Baird, Jiyuan Ma, Rosemary Barrett, Dhiren D'Silva, Kylie O'Keefe, Ronald Kong

2020-Current year OA Pubs

Unesbulin is being investigated in combination with dacarbazine (DTIC) as a potential therapeutic agent in patients with advanced leiomyosarcoma (LMS). This paper reports the pharmacokinetics (PK) of unesbulin, DTIC, and its unreactive surrogate metabolite 5-aminoimidazole-4-carboxamide (AIC) in 29 patients with advanced LMS. Drug interactions between DTIC (and AIC) and unesbulin were evaluated. DTIC (1000 mg/m

Efficacy And Safety Of Teprotumumab In Patients With Thyroid Eye Disease Of Long Duration And Low Disease Activity, Raymond S Douglas, Steven Couch, Sara T Wester, Brian T Fowler, Catherine Y Liu, Prem S Subramanian, Rosa Tang, Quang T Nguyen, Robi N Maamari, Shoaib Ugradar, Kate Hsu, Michael Karon, Marius N Stan

2020-Current year OA Pubs

CONTEXT: Early inflammatory thyroid eye disease (TED) can lead to symptomatic chronic disease, including disabling proptosis. Teprotumumab, an insulin-like growth factor-1 receptor (IGF-1R) inhibitor, previously demonstrated efficacy in acute, high-inflammation TED trials.

OBJECTIVE: We present data from the first placebo-controlled trial with teprotumumab in chronic/low disease activity TED.

METHODS: This randomized double-masked, placebo-controlled trial, conducted at 11 US centers, enrolled adult participants with TED duration of 2 to 10 years, Clinical Activity Score (CAS) ≤ 1 or no additional inflammation or progression in proptosis/diplopia for ≥1 year, proptosis ≥3 mm from before TED and/or from normal, euthyroid/mildly hypo/hyperthyroid, no prior …

Intergenerational Co-Production In Digital Design For Health, Well-Being, And Social Connection, Catherine Hennessy, Greg Mannion, Richard Haynes, Anna Whittaker, Hannah Bradwell, Simone Tomaz, John Ritchie, Leonie Cooper

School of Nursing and Midwifery

No abstract provided.

Exploring Attitudes Toward “Sugar Relationships” Across 87 Countries: A Global Perspective On Exchanges Of Resources For Sex And Companionship, Norbert Meskó, Marta Kowal, András Láng, Ferenc Kocsor, Szabolcs A. Bandi, Adam Putz, Piotr Sorokowski, David A. Frederick, Felipe E. García, Leonardo A. Aguilar, Anna Studzinska, Chee Seng Tan, Biljana Gjoneska, Taciano L. Milfont, Bulut M Topcu, Dmitry Grigoryev, Toivo Aavik, Mahmoud Boussena, Alan D.A. Mattiassi, Reza Afhami, Rizwana Amin, Roberto Baiocco, Hamdaoui Brahim, Ali R. Can, Joao Carneiro, Hakan Çetinkaya, Dimitri Chubinidze, Eliane Deschrijver, Yahya Don, Dmitrii Dubrov, Izzet Duyar, Marija Jovic, Julia A. Kamburidis, Farah Khan, Hareesol Khun-Inkeeree, Maida Koso-Drljevic, David Lacko, Karlijn Massar, Mara Morelli, Jean C. Natividade, Ellen K. Nyhus, Ju Hee Park, Farid Pazhoohi, Ekaterine Pirtskhalava, Koen Ponnet, Pavol Prokop, Dušana Šakan, Singha Tulyakul, Austin H. Wang, Sibele D. Aquino, Derya D. Atamtürk, Nana Burduli, Antonio Chirumbolo, Seda Dural, Edgardo Etchezahar, Moharrampour N Ghahraman, Balazs Aczel, Luca Kozma, Samuel Lins, Efisio Manunta, Tiago Marot, Moises Mebarak, Kirill G. Miroshnik, Katarina Misetic, Marietta Papadatou-Pastou, Bence Bakos, Fatima Zahra Sahli, Sangeeta Singh, Çağlar Solak, Tatiana Volkodav, Anna Wlodarczyk, Grace Akello, Marios Argyrides, Ogeday Çoker, Katarzyna Galasinska, Yepes T Gómez, Aleksander Kobylarek, Miguel Landa-Blanco, Marlon Mayorga, Barış Özener, Ma Criselda T. Pacquing, Marc Eric S. Reyes, Ayşegül Şahin, William Tamayo-Agudelo, Gulmira Topanova, N/A Toplu-Demir

School of Psychology

The current study investigates attitudes toward one form of sex for resources: the so-called sugar relationships, which often involve exchanges of resources for sex and/or companionship. The present study examined associations among attitudes toward sugar relationships and relevant variables (e.g., sex, sociosexuality, gender inequality, parasitic exposure) in 69,924 participants across 87 countries. Two self-report measures of Acceptance of Sugar Relationships (ASR) developed for younger companion providers (ASR-YWMS) and older resource providers (ASR-OMWS) were translated into 37 languages. We tested cross-sex and cross-linguistic construct equivalence, cross-cultural invariance in sex differences, and the importance of the hypothetical predictors of ASR. Both measures …

Harm Reduction In Undergraduate And Graduate Medical Education: A Systematic Scoping Review, Kelsey R. Smith, Nina K. Shah, Abby L. Adamczyk, Lara C. Weinstein, Erin L. Kelly

Department of Family & Community Medicine Faculty Papers

BACKGROUND: Substance use increasingly contributes to early morbidity and mortality, which necessitates greater preparation of the healthcare workforce to mitigate its harm. The purpose of this systematic scoping review is to: 1) review published curricula on harm reduction for substance use implemented by undergraduate (UME) and graduate medical education (GME) in the United States and Canada, 2) develop a framework to describe a comprehensive approach to harm reduction medical education, and 3) propose additional content topics for future consideration.

METHODS: PubMed, Scopus, ERIC: Education Resources Information Center (Ovid), and MedEdPORTAL were searched. Studies included any English language curricula about harm …

Willie Russell

African American Funeral Programs

No abstract provided.

Breaking The Non-Compete Cycle: A Legal And Economic Analysis Of The Ftc's Power Move, Stephen Fox

University of Cincinnati Law Review

No abstract provided.

Releasing The Captives: How The National Labor Relations Board Can Correct The Anomalous Captive Audience Meeting Doctrine, Adam J. Drapcho

University of Cincinnati Law Review

No abstract provided.

A Right Without A Remedy: How One Cincinnatian's Story Illustrates Terrorism Victims' Inability To Obtain Compensation Under The Foreign Sovereign Immunities Act, Christopher T. Colloton

University of Cincinnati Law Review

No abstract provided.

Vega V. Tekoh And The Erosion Of Miranda: A Reframing Of Miranda As A Procedural Due Process Requirement, Tess A. Chaffee

University of Cincinnati Law Review

No abstract provided.

Becoming "Audit" It Can Be: Improving Public School Funding Through A Streamlined Sales And Use Tax Agreement For Real Property Tax, Megan E. Bowling

University of Cincinnati Law Review

No abstract provided.

Value Judgments In Judicial Reasoning, And The Instability Of The Fact-Law Distinction, Stephen A. Simon

University of Cincinnati Law Review

No abstract provided.

Must Courts Recalibrate Tort Law Governing Firearms In Light Of The Second Amendment?, Lars Noah

University of Cincinnati Law Review

The rules governing the scope of liability in cases where firearms cause injuries—some well-established, others fairly novel—help to define the responsibilities of users, owners, and sellers of these popular but dangerous products. As the U.S. Supreme Court has recently expanded an individual’s right to keep and bear arms, some have wondered whether the Second Amendment might operate to limit the reach of these various tort doctrines. Sixty years ago, the Court started to constitutionalize various aspects of state common law, most famously using the First Amendment to limit defamation claims but in other respects as well. A comparable approach to …

Pooling And Exchanging Competitively Sensitive Information Among Rivals: Absolutely Illegal Not Just Unreasonable, Peter C. Carstensen, Annkathrin Marschall

University of Cincinnati Law Review

An agreement to exchange competitive sensitive information among rivalrous competitors usually results from an intent to inhibit or restrict the discretion of those firms to engage in competition. Basic economic logic about competition leads to that conclusion. Hence, such an exchange is in itself a naked agreement in restraint of trade without legal justification. Currently, case law requires a more convoluted and irrelevant inquiry into market definition and market power before a court can condemn such agreements. This is the result of ambiguous Supreme Court decisions as well as the recognition that in a few instances there are plausible arguments …

Section 230 As Civil Rights Statute, Enrique Armijo

University of Cincinnati Law Review

Many of our most pressing discussions about justice, progress, and civil rights have moved online. Activists advocating for social change no longer need to be in the same physical space to connect with others who share their challenges and aspirations. But the convergence of mobility, connectivity, and technology is not the only reason why. Thanks to Section 230 of the Communications Decency Act’s (“Section 230”) immunity for online platforms, websites, and their hosts, speakers can engage in speech about protest, equality, and dissent without fear of collateral censorship from governments, authorities, and others in power who hope to silence them. …

Perceived Importance Of Ultrasound Vascular Access Education Among Residents, Raquel Lamarche, Jared Marx, Jihyun Ma, Stephanie Claudy

Graduate Medical Education Research Journal

Background: Peripheral intravenous catheter (PIVC) failure and difficult intravenous access (DIVA) are pervasive issues causing patient suffering and increased costs. Despite their prevalence, there is a gap in internal medicine and pediatric resident training to manage these challenges effectively.

Objective: This study aimed to assess the value of ultrasound-guided-PIVC (USGPIVC) education for internal medicine and pediatric residents and the impact of a 1-hour multidisciplinary workshop on their knowledge and confidence.

Methods: A cross-sectional survey study was conducted at an academic medical center in 2022 to assess residents’ perceptions of USG-PIVC education. This was followed by a USG-PIVC simulation-based workshop with …

Engaging Community Partners To Enrich Preschoolers Learning Experiences With Dramatic Inquiry, Kathleen M. Farrand, Wendy Peia Oakes, Megan Troxel Deeg, Katelyn Jaworksi, Veronica Leon

Journal of the Arts and Special Education

Interdisciplinary teams of adults are needed to enhance the capacity of schools to provide the most appropriate educational experiences for young children who have or are at risk for developmental delays and disabilities (Division for Early Childhood, 2014). When educators, families, and community partners connect around shared goals, we begin to reimagine instructional opportunities and create more equitable access to educational resources for children and families. We share insights from community partners who participated in a collaborative dramatic inquiry study designed to enrich preschoolers’ learning experiences and serve children and families.

Multisensory Adaptations: Creating Art With Students Who Are Blind And Low Vision, Jasmine Begeske, Leslie Walsh, David Ray Miranda

Journal of the Arts and Special Education

The main purpose of this article is to present approaches and strategies to making 2-D visual arts instruction meaningful and accessible for students who are blind or low vision. The suggestions provided within this article are based on current literature, researcher observations, and the contributions of an experienced, practicing art teacher at the Indiana School for the Blind and Visually Impaired.

Jase 3.1 Front Matter

Journal of the Arts and Special Education

JASE 3.1 Front Matter

Optimizing Audio Beams And Camera Cropping In Collaborative Workspaces Based On Mute Button Locations, Sigurd Klasson

Defensive Publications Series

In collaborative workspaces, such as meeting rooms, it is desirable to optimize the direction of audio pickups (referred to herein interchangeably as 'beams') and also camera cropping to be focused on the location of a participant that is currently speaking during a collaborative session. Such optimizations are typically performed using audio triangulation techniques based on a speaker that is actively speaking during a meeting. However, when the audio in a meeting room is muted, it can be difficult to direct room cameras toward a meeting participant that desires to speak, as the audio triangulation techniques may be limited when no …

Book Review: Inequality In America: Causes And Consequences, Eya Mahouachi

The Journal of Values-Based Leadership

Inequality in America: Causes and Consequences is a recent book authored by Rycroft (economics, Univ. of Mary Washington, Fredericksburg, VA) and Kinsley (business law, Univ. of Mary Washington, Fredericksburg, VA) and was written by scholars, advanced graduate students, and expert practitioners. Their book attempts to bridge the gap in scholarship and practice by incorporating the causes and consequences of history, the current state of inequality in the United States, and future consequences if left unresolved. This book is structured according to fundamental topics such as education, healthcare, housing, environmental issues, and the justice system. Using an effective approach to teaching …

Miracle On The High Seas, A True Story: A Case Of Faith, Heroism, Love, And Compassion, Emilio Iodice

The Journal of Values-Based Leadership

No abstract provided.

"Being On God’S Side": Biblical Leaders On Wokeness, Social Justice, Cancel Culture, White Privilege, And Other Controversial Terms, Hershey H. Friedman, Svetlana Vlady

The Journal of Values-Based Leadership

Terms such as “woke,” “social justice,” “cancel culture,” “identity politics,” “politically correct,” “critical race theory,” and “DEI” have been increasingly misused and politicized by both the left and the right in recent years. This paper will examine the Hebrew Bible and explore what it says about social justice, compassion for the indigent, inclusion, and many other terms causing such an uproar. The authors assert that the ancient prophets, the true social justice warriors, would be horrified by the actions of both the left and right.

The Trader Joe’S Way (To Success), Ritch Eich, Joan Taylor Cummings Eich

The Journal of Values-Based Leadership

No abstract provided.

Top Directed, Bottom Driven: Subaru Tackles Waste (Interview With Denise Coogan, Subaru), Elizabeth Gingerich

The Journal of Values-Based Leadership

No abstract provided.

The Intersection Of Leader-Follower Trade (Lft) And Leader-Member Exchange (Lmx) In Alleviating Work-Family Conflict (Wfc), Ashlie James

The Journal of Values-Based Leadership

In an organizational context, employees are more than mere followers but individuals with multiple roles beyond their employment which interact and influence the way they work. When the demands from work and family life collide, scholars describe this inter-role conflict as work–family conflict (WFC) where the role pressures from work and family are mutually incompatible creating increased feelings of strain and decreased life and job satisfaction which affect their work performance and commitment (Blanch & Aluja, 2012; Hagqvist et al., 2017). Given the importance of having work-life balance, human resource management (HRM) theory argues work flexibility, such as the opportunity …

Ethical Leadership: A Study Of Behaviors Of Leaders In Higher Education Today, Jonathan Hubchen, Samuel L. Wyatt, Michael Burnett

The Journal of Values-Based Leadership

The primary purpose of this study was to determine the behaviors of an ethical leader as perceived by tenured and tenure-track faculty at a research university (RU/VH) in the southeastern portion of the United States. The researcher utilized a researcher-designed survey instrument which consisted of twenty possible behaviors of an ethical leader and selected demographic characteristics.

Examination of the study results revealed that the majority of respondents were male (66.20%) and tenured (75.00%). Additionally, the largest group were Professors (49.60%), and had been at the study institution for less than l0 years (38.20%). The characteristics that were most related to …

Three Conditions For Vertical Leadership Development: Impact Of Personal Experiences, Kevin Coopersmith

The Journal of Values-Based Leadership

Vertical leadership development, an emerging body of leadership research based around expanding an individual’s capacity to think, make decisions, and understand themselves and the world around them, stands as a unique solution to address the leadership skills gap at a time of global complexity and change. Petrie’s (2015) model of the three conditions for vertical leadership development to take place was analyzed through the lived experiences of eight leaders who had successfully completed personal development plans and shared their experiences through a narrative-based qualitative study. Of the eight participants, three participants filled all three conditions and demonstrated a higher level …

Authentic Leadership Measures: An Authentic Measure For Authentic Leadership?, Mitch Butterworth, Jessica Black, Robert Terry

The Journal of Values-Based Leadership

This study broadly addresses some of the criticisms associated with authentic leadership theory related to measurement and antecedents. Measurement: One purpose of this study was to verify the dimensionality of authentic leadership by testing the construct validity of three measures for authentic leadership: the Authentic Leadership Questionnaire (ALQ), the Authentic Leadership Inventory (ALI), and the Authentic Leadership Integrated Questionnaire (AL-IQ), proposed by Levesque-Cote et al. (2018) as an improvement on the previous two scales. This study was designed to replicate and extend Levesque-Cote et al. (2018) study with an English-speaking sample to further test the structural validity of the AL-IQ. …