Digital Commons Network^™

Protein Enriched Bread Using Spent Wine Yeast, Zachary Christman

Applied Science Program: Theses

Yeast is a common byproduct of wine production. Wine yeast may be used as a food source. It does not contain bitter and astringent compounds such as those present in spent yeast from making beer The use of nutritional yeast and yeast extract for protein enrichment of bread are presented in this article.

Tafopathies Result From Derangements In Transcriptional Regulation Of Metabolism, Jamison Maxwell Leid

Arts & Sciences Graduate Student Theses and Dissertations

Cardiogenesis and the maintenance of cardiac physiology necessitate dynamic and carefully coordinated transcription programs. Studies in a many systems – both in vitro and in vivo – have elucidated critical signaling pathways, including Bmp, Fgf, Wnt, and Notch that induce a cardiogenic transcription program, thereby driving cardiac specification and differentiation. Recently, studies have discovered additional regulation at the epigenetic level that contributes to the tight temporal and spatial control of cardiac gene expression during development. Because transcriptional regulation is essential to cardiogenesis, changes in transcriptional regulation result in developmental defects, including but not limited to CHDs, the leading inborn cause …

Unh Dining Halls Earn Highest Ranking Possible From Green Restaurant Association, Keith Testa

UNH Today Archive

No abstract provided.

Lem2 Is Essential For Cardiac Development By Maintaining Nuclear Integrity, Jacob A Ross, Didier Hodzic, Et Al.

2020-Current year OA Pubs

AIMS: Nuclear envelope integrity is essential for the compartmentalization of the nucleus and cytoplasm. Importantly, mutations in genes encoding nuclear envelope (NE) and associated proteins are the second highest cause of familial dilated cardiomyopathy. One such NE protein that causes cardiomyopathy in humans and affects mouse heart development is Lem2. However, its role in the heart remains poorly understood.

METHODS AND RESULTS: We generated mice in which Lem2 was specifically ablated either in embryonic cardiomyocytes (Lem2 cKO) or in adult cardiomyocytes (Lem2 iCKO) and carried out detailed physiological, tissue, and cellular analyses. High-resolution episcopic microscopy was used for three-dimensional reconstructions …

Effect Of An Rn-Facilitated Post Discharge Phone Call Hf Self-Management Strategy, Vivia O. Haye

Dissertations

Heart Failure (HF) is associated with substantial financial challenges resulting in exorbitant yearly costs, and frequent readmits to the emergency department. Post-discharge HF self-management is crucial to improve client outcomes. The purpose of this quantitative, quasi-experimental, project was to examine whether the implementation of an RN-facilitated post-discharge phone call that focused on HF self-management strategies reduced return emergency department (ED) visits within 72 hours in an urban South Florida hospital. Orem's self-care theory and the Meleis transition model were used for their success in managing chronic illnesses such as HF. Both examined if an RN facilitated post-discharge telephone call that …

State Public Assistance Spending And Survival Among Adults With Cancer, Justin M Barnes, Kenton J Johnston, Kimberly J Johnson, Fumiko Chino, Nosayaba Osazuwa-Peters

2020-Current year OA Pubs

IMPORTANCE: Social determinants of health contribute to disparities in cancer outcomes. State public assistance spending, including Medicaid and cash assistance programs for socioeconomically disadvantaged individuals, may improve access to care; address barriers, such as food and housing insecurity; and lead to improved cancer outcomes for marginalized populations.

OBJECTIVE: To determine whether state-level public assistance spending is associated with overall survival (OS) among individuals with cancer, overall and by race and ethnicity.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study included US adults aged at least 18 years with a new cancer diagnosis from 2007 to 2013, with follow-up through 2019. Data …

Periodical Cicadas (Magicicada Spp.): Predator Satiation, Or Too Much Of A Good Thing?, John R. Cooley, Greg Holmes

The Great Lakes Entomologist

We report a novel mode of ecdysis failure in periodical cicadas (Magicicada spp. Davis) tied to the cicadas’ reliance on high densities for survival in the face of predation. Under extremely high densities, cicadas can disrupt others undergoing ecdysis by knocking them loose from their perches, trapping them, or causing physical damage. Our observations raise the possibility that while periodical cicadas thrive at high densities, it is possible that some densities are so high that they inhibit success.

Observations On Two Stem-Boring Coleoptera Of Prickly-Ash (Zanthoxylum Americanum) In Michigan: Micracis Suturalis (Curculionidae: Scolytinae) And Sternidius Alpha (Cerambycidae), Robert A. Haack

The Great Lakes Entomologist

The xylophagous scolytine Micracis suturalis LeConte and the cerambycid beetle Sternidius alpha (Say) were reared or collected from trunk sections of prickly-ash, Zanthoxylum americanum Mill., in Ingham County, Michigan during 1986 to 1988. Most M. suturalis gallery systems were initiated by August in host material cut in late May 1987. Micracis suturalis gallery-system density data are presented. No M. suturalis were reared from caged host material one-year after cutting. Sternidius alpha was univoltine, with adults emerging from mid-May to mid-July from host material cut the previous spring. From 1 to 8 S. alpha larvae originated from individual oviposition sites, averaging …

Gamerfit-Asd Beta Test: Adapting An Evidence-Based Exergaming And Telehealth Coaching Intervention For Autistic Youth, Daniel P. Hatfield, Aviva Must, Winston Kennedy, Amanda E. Staiano, James Slavet, Rachael A. Sabelli, Carol Curtin, Linda G. Bandini, Phillip Nauta, Christopher Stuetzle, April Bowling

Computer and Data Science Faculty Publications

Background: Health disparities faced by autistic youth are exacerbated by inadequate physical activity (PA) and sleep, whereas healthy PA and sleep may improve mood and function. Adaptive Game Squad (AGS) is an evidence-based telehealth coaching and exergaming intervention to improve PA and sleep for adolescents with diverse neurodevelopmental and psychiatric conditions. This study aimed to adapt AGS for autistic youth ages 10–15 years; beta-test the modified intervention for feasibility, accessibility, and engagement; and further refine the intervention for a larger planned demonstration pilot.

Methods: Interdisciplinary experts adapted AGS to create GamerFit-ASD, a 12-week intervention that included a progressive exergame schedule, …

On A Central Problem Of The Human Placenta Project, Charles F. Babbs

Weldon School of Biomedical Engineering Faculty Working Papers

This brief technical note describes a design concept for a low-cost, painless, noninvasive monitor of total placental blood flow during the third trimester of pregnancy. The approach may offer an overlooked solution to a central problem of the human placenta project. A systems level biophysical analysis shows that jets of blood flow emerging from spiral arteries in the placenta generate characteristic 1/f or “pink noise” which is routinely audible, but typically ignored, during fetal phonocardiography. The amplitude of the 1/f noise, recorded at a standardized location in an individual patient, is a measure of total placental blood flow that is …

Design, Analysis, And Interpretation Of Treatment Response Heterogeneity In Personalized Nutrition And Obesity Treatment Research, Roger S. Zoh, Bridget H. Esteves, Xiaoxin Yu, Amanda J. Fairchild, Ana I. Vazquez, Andrew G. Chapple, Andrew W. Brown, Brandon George, Derek Gordon, Douglas Landsittel, Gary L. Gadbury, Greg Pavela, Gustavo De Los Campos, Luis M. Mestre, David B. Allison

School of Public Health Faculty Publications

It is increasingly assumed that there is no one-size-fits-all approach to dietary recommendations for the management and treatment of chronic diseases such as obesity. This phenomenon that not all individuals respond uniformly to a given treatment has become an area of research interest given the rise of personalized and precision medicine. To conduct, interpret, and disseminate this research rigorously and with scientific accuracy, however, requires an understanding of treatment response heterogeneity. Here, we define treatment response heterogeneity as it relates to clinical trials, provide statistical guidance for measuring treatment response heterogeneity, and highlight study designs that can quantify treatment response …

Evaluation Of In Vitro Antioxidant, Anti-Obesity, And Anti-Diabetic Activities Of, Alaa S Mohamed, Essam Mohamed Elsebaie, Wesam Mohammed Abdelrhman, Nabila Yahia Mahmoud Abdulmaguid, Rasha M Bahnasy, Manal Salah Abbas Elgendy, Arwa Mohamed Mohamed Mahmoud Elashry, Marwa Fawzy El-Hassanin, Nora Hamdy Mouhamed El-Wakeil, Azhar Mostafa Mohamed Khalil, Hesham F Amin

Faculty, Staff and Student Publications

Opuntia ficus cladodes (OFC) are considered one of the wastes that result from opuntia cultivation, and their disposal by traditional methods results in many environmental problems. Therefore, this study was conducted with two aims. The first was the production of OFC gel, and the evaluation of its in vitro antioxidant (by two methods, DPPH and ABTS), anti-obesity, and anti-diabetic activities. The second was an investigation of the effects of different concentrations of this gel (0, 50, and 100%) as an edible coating on the quality of shrimp during 8 days of refrigerated storage. The results showed that this gel was …

Mitochondrial Pyruvate Metabolism And Glutaminolysis Toggle Steady-State And Emergency Myelopoiesis, Hannah A Pizzato, Yahui Wang, Michael J Wolfgang, Brian N Finck, Gary J Patti, Deepta Bhattacharya

2020-Current year OA Pubs

To define the metabolic requirements of hematopoiesis, we examined blood lineages in mice conditionally deficient in genes required for long-chain fatty acid oxidation (Cpt2), glutaminolysis (Gls), or mitochondrial pyruvate import (Mpc2). Genetic ablation of Cpt2 or Gls minimally impacted most blood lineages. In contrast, deletion of Mpc2 led to a sharp decline in mature myeloid cells and a slower reduction in T cells, whereas other hematopoietic lineages were unaffected. Yet MPC2-deficient monocytes and neutrophils rapidly recovered due to a transient and specific increase in myeloid progenitor proliferation. Competitive bone marrow chimera and stable isotope tracing experiments demonstrated that this proliferative …

In Vitro Antioxidant, Anti-Inflammatory, And Photoprotective Activities Of Aqueous Extract Of The Endemic Plant Hammada Scoparia L. From Algeria, Benine Chaima, Djahra Ali Boutlelis, Laiche Ammar Touhami, Tlili Hajer, Tliba Ali, Ben Arfa Abdelkarim, Najjaa Hanen

Karbala International Journal of Modern Science

This study aimed to analyze the chemical profile and evaluate the biological activities of the aqueous extract of H. Scoparia, an endemic plant found in Southeastern Algeria. The aqueous extract was subjected to phytochemical screening, RP-HPLC, and FT-IR analysis. The anti-inflammatory activity was examined using the protein denaturation method, and the photoprotective activity was evaluated using UV-Visible spectrophotometry. The antioxidant activity was assessed using ABTS, DPPH, and FRAP assays. The study found the presence of various secondary metabolites such as polyphenols, tannins, and saponins. This study suggests that H. Scoparia extract has the potential as a natural source of bio-actives …

Open-Label Study Of Consecutive Ibogaine And 5-Meo-Dmt Assisted-Therapy For Trauma-Exposed Male Special Operations Forces Veterans: Prospective Data From A Clinical Program In Mexico, Alan Kooi Davis, Yitong Xin, Nathan Sepeda, Lynnette A Averill

Staff and Researcher Publications

Background: Research in psychedelic medicine has focused primarily on civilian populations. Further study is needed to understand whether these treatments are effective for Veteran populations.

Objectives: Here, we examine the effectiveness of psychedelic-assisted therapy among trauma-exposed Special Operations Forces Veterans (SOFV) seeking treatment for cognitive and mental health problems in Mexico.

Methods: Data were collected from an ibogaine and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) clinical treatment program for SOFV with a history of trauma exposure. This clinical program collects prospective clinical program evaluation data, such as background characteristics, symptom severity, functioning (e.g., satisfaction with life, posttraumatic stress disorder symptoms, depression symptoms, anxiety symptoms, …

Mesenchymal-Derived Extracellular Vesicles Enhance Microglia-Mediated Synapse Remodeling After Cortical Injury In Aging Rhesus Monkeys, Yuxin Zhou, Hrishti Bhatt, Chromewell A. Mojica, Hongqi Xin, Monica A. Pessina, Douglas L. Rosene, Tara L. Moore, Maria Medalla

Neurology Articles

Understanding the microglial neuro-immune interactions in the primate brain is vital to developing therapeutics for cortical injury, such as stroke or traumatic brain injury. Our previous work showed that mesenchymal-derived extracellular vesicles (MSC-EVs) enhanced motor recovery in aged rhesus monkeys following injury of primary motor cortex (M1), by promoting homeostatic ramified microglia, reducing injury-related neuronal hyperexcitability, and enhancing synaptic plasticity in perilesional cortices. A focal lesion was induced via surgical ablation of pial blood vessels over lying the cortical hand representation of M1 of aged female rhesus monkeys, that received intravenous infusions of either vehicle (veh) or EVs 24 h …

The Wealth Of Our Commonwealth: Money, Capital, And Finance In A Productive Commercial Republic, Robert Hockett

The Business, Entrepreneurship & Tax Law Review

There is a share of the investment capital available in any society that is generated by the public. In contemporary societies with well-developed payment systems and effective public governance, this share tends to grow large in comparison to that originated by non-public sources, the latter is intermediated and thus must be pre-accumulated, while the former is generated and is the source of what is accumulated. In spite of these truths, the US outsources management of its public capital stock to private sector financial institutions. This is a practice that a host of underappreciated collective action predicaments endemic to decentralized market …

Development Of A Culturally Adapted Dietary Intervention To Reduce Alzheimer's Disease Risk Among Older Black Adults, Ashley R Shaw, Mickeal N Key, Samantha Fikru, Saria Lofton, Debra K Sullivan, Jannette Berkley-Patton, Crystal M Glover, Jeffrey M Burns, Eric D Vidoni

Faculty, Staff and Student Publications

The objective of this study is to identify and understand knowledge and attitudes that influence dietary practices among older Black adults using a community-engaged approach. This is a non-interventional mixed methods study designed to inform the development of an adapted brain-healthy soul food diet intervention. A purposive sampling approach was used to conduct seven semi-structured focus group discussions and an online quantitative survey. In total, 39 participants who self-identified as Black, aged 55 years and older, English speaking, and who were cognitively normal with an AD8 < 2; (25.6% men; 74.4% women) participated in the online survey and one of the seven 60 min virtual focus group discussions (5-7 per focus group). Quantitative frequency data from the online surveys were analyzed using descriptive statistics. Qualitative focus group data were analyzed using a 6-step thematic analysis process. Five themes emerged: dementia awareness; practices shaping food choices and consumption; barriers to eating healthy; instrumental support; and elements of a culturally adapted brain-healthy dietary intervention. Older Black adults perceived an adapted MIND dietary model as the most acceptable with the incorporation of salient cultural characteristics and strategies within both the design and delivery phases.

The Effects Of Different Training Types On Phase Angle In Men - An Exploratory Study, Trevor Short, Paulette Yamada

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 4: Issue 1, Article 12, 2023. Phase Angle (PhA) has emerged as a valuable measure in clinical and sports settings due to its predictive relationship with health and sports performance. Fitness is related to PhA, but the type of exercise training that is most influential over PhA has yet to be determined. The purpose was to explore the effects of endurance training (ET), strength-based resistance training (RT), and sprint-interval training (SIT) on PhA, resistance (R), and reactance (Xc) in men. Thirty-five recreationally-trained healthy young adult males (24±4 years) were randomly assigned to one …

Bulletin Of The Virginia State Dental Association (Vol. 38, No. 1, 1961)

Bulletin of the Virginia State Dental Association

No abstract provided.

Prevalence Of Adulteration In Dietary Supplements And Recommendations For Safe Supplement Practices In Sport, Andrew R. Jagim, Patrick Harty, Jacob L. Erickson, Grant M. Tinsley, Dan Garner, Andrew J. Galpin

Faculty Scholarship

The prevalence of dietary supplement use among athletes continues to rise with 60–80% of athletes often reporting current or previous use of dietary supplements. While select dietary ingredients have been shown to improve acute performance and enhance training adaptations over time, it is important to still consider the risk vs. reward for athletes before opting to consume a dietary supplement. Previous work has indicated that certain dietary supplements may pose risks for inadvertent doping, may be susceptible to mislabelling, could be banned by certain governing bodies of sport, or pose health risks for certain populations. The purpose of the current …

Endoscopic Ultrasound-Guided Transluminal Gallbladder Drainage In Patients With Acute Cholecystitis: A Prospective Multicenter Trial., Shayan S Irani, Neil R. Sharma Md, Andrew C Storm, Raj J Shah, Prabhleen Chahal, Field F Willingham, Lee Swanstrom, Todd H Baron, Eran Shlomovitz, Richard A Kozarek, Joyce A Peetermans, Edmund Mcmullen, Evelyne Ho, Schalk W Van Der Merwe

Other Specialties

OBJECTIVE: To evaluate the safety and efficacy of endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) using a lumen-apposing metal stent (LAMS).

BACKGROUND: For patients with acute cholecystitis who are poor surgical candidates, EUS-GBD using a LAMS is an important treatment alternative to percutaneous gallbladder drainage.

METHODS: We conducted a regulatory-compliant, prospective multicenter trial at 7 tertiary referral centers in the United States of America and Belgium. Thirty consecutive patients with mild or moderate acute cholecystitis who were not candidates for cholecystectomy were enrolled between September 2019 and August 2021. Eligible patients had a LAMS placed transmurally with 30 to 60-day indwell if …

Variables Affecting The Mothers Access To Quality Care During Childbirth Using The Neural Networks And Logistic Regression Models, H. E. Semary, I. M. Abd El-Fatah, S. E. El-Desouky, M. M. El-Madawye

Journal of Statistics Applications & Probability

Quality pregnancy and birth care is crucial in reducing maternal and child mortality in Egypt, requiring both supply and demand interventions. Using data from the Egypt Demographic Health Survey 2014, a neural networks and logistic regression models were built to determine demographic, social, and economic determinants affecting mothers access to care during childbirth. The study found that mothers working status had a significant impact on access to care, with an inverse relationship. Logistic regression outperformed neural networks in analyzing the relationship between explanatory variables and mothers access to care during childbirth.

Correlation Between Life Style And Gingival Health In Adult Patients In Erbil City-Iraq, Shahida Rassul Hussein

Polytechnic Journal

ABSTRACT Back ground and Objective: Gingivitis conceder as one of the most common, gum diseases. lifestyle choices can related to gingivitis such as diet, oral hygiene practices, regular dental visits and smoking . The objective of this study was to determine the relationship between life style and gingivitis of adult population in Erbil city. Methods: effect of life style on gingival health was determined for 360 patients age between 20-70years of both genders, visiting Erbil medical centers. Clinical examination of the gingival health was performed by reporting plaque, gingival indices by periodontal prob. Lifestyle was detected by questions about dietary …

Allelopathic Effect Of Sidr (Ziziphus Spina- Christi (L.) Wild.) Leaf Extracts On Seed Germination And Seedling Parameters, Nohra Shwan Hanna, Yaseen Ahmed Rasheed Goran

Polytechnic Journal

Plants have several direct or indirect effects on other surrounding organisms in which it may be harmful or beneficial, in this study the potential allopathic effects of Ziziphus spina-christi (Sidr) leaf extracts were investigated alongside wheat (Triticum aestivum L), barley (Hordeum vulgare L.), cress (Lepidium sativum L.) and fenugreek (Trigonella foenum-graecum L.) Seeds for the observation of their germination, in which different concentrations (0%, 2.5%, 5.0%, 7.5%, and 10%) of sidr aqueous and methanolic extracts (70% methanol) were made and used against these seeds in vitro and their effect on germination was determined. This experiment showed a significant inhibitory effect …

Effects Of Two Exercise Programs On Neck Proprioception In Patients With Chronic Neck Pain: A Preliminary Randomized Clinical Trial, Leila Rahnama, Mark Daniel Geil

Faculty Articles

Background: The purpose of this study was to compare the effects of specific neck muscle training and general neck-shoulder exercises on neck proprioception, pain, and disability in patients with chronic non-specific neck pain. Methods: Twenty-five patients with chronic non-specific neck pain were recruited into this preliminary single-blinded randomized clinical trial. They were randomly assigned to either a specific neck exercise (n = 13, mean aged 24 years) or a general neck exercise group (n = 12, mean aged 25 years). Specific neck exercises included eye-head coordination and isometric deep neck muscle exercises. General neck exercises included neck and shoulder free …

The Population, Environmental Risks, And Climate Crisis (Percc) Initiative, Population Council

Population, Environmental Risks, and the Climate Crisis (PERCC)

This brief describes the Population Council's PERCC initiative which conducts rigorous, innovative, cross-disciplinary social science research; uses it to build publicly accessible datasets, tools, and models; and utilizes our findings and insights to help shape climate adaptation policy at every level, from municipalities to national strategies and United Nations agencies. The Council’s approach is underpinned by a climate justice lens, acknowledging that those who contribute the least to climate change are disproportionately harmed.

Selected Fermented Indigenous Vegetables And Fruits From Malaysia As Potential Sources Of Natural Probiotics For Improving Gut Health, Olaide Olawunmi Ajibola, Raymond Thomas, Babatunde Femi Bakare

Biochemistry Publications

In the Peninsular Malaysia and Northern Borneo island of Malaysia, various rich indigenous leafy vegetables and fruits grow and contribute to the nutritional and dietary values of the population. They have high water contents, thus, naturally vulnerable to rapid food spoilage. Food preservation and processing play a vital role in the inhibition of food pathogens in fruits and vegetables that are prevalent in Malaysia. Lactic acid fermentation is generally a local-based bioprocess, among the oldest form and well-known for food-processing techniques among indigenous people there. The long shelf life of fermented vegetables and fruits improves their nutritional values and antioxidant …

Sts-352 (101): Race And Ethnicity, Laura Dickerman

Humanities Syllabi

No abstract provided.

A Roadmap For The Human Gut Cell Atlas, Matthias Zilbauer, Kylie R. James, Mandeep Kaur, Sebastian Pott, Zhixin Li, Albert Burger, Jay R. Thiagarajah, Joseph Burclaff, Frode L. Jahnsen, Francesca Perrone, Alexander D. Ross, Gianluca Matteoli, Nathalie Stakenborg, Tomohisa Sujino, Andreas Moor, Raquel Bartolome-Casado, Espen S. Bækkevold, Ran Zhou, Bingqing Xie, Ken S. Lau, Shahida Din, Scott T. Magness, Qiuming Yao, Semir Beyaz, Mark Arends, Alexandre Denadai-Souza, Lori A. Coburn, Jellert T. Gaublomme, Richard Baldock, Irene Papatheodorou, Jose Ordovas-Montanes, Guy Boeckxstaens, Anna Hupalowska, Sarah A. Teichmann

School of Computing: Faculty Publications

The number of studies investigating the human gastrointestinal tract using various single-cell profiling methods has increased substantially in the past few years. Although this increase provides a unique opportunity for the generation of the first comprehensive Human Gut Cell Atlas (HGCA), there remains a range of major challenges ahead. Above all, the ultimate success will largely depend on a structured and coordinated approach that aligns global efforts undertaken by a large number of research groups. In this Roadmap, we discuss a comprehensive forward-thinking direction for the generation of the HGCA on behalf of the Gut Biological Network of the Human …