Digital Commons Network^™

Antibiotic-Induced Gut Dysbiosis And Cognitive, Emotional, And Behavioral Changes In Rodents: A Systematic Review And Meta-Analysis, Shivdeep S. Hayer, Soonjo Hwang, Jonathan B. Clayton

Food for Health: Publications

There are previous epidemiological studies reporting associations between antibiotic use and psychiatric symptoms. Antibiotic-induced gut dysbiosis and alteration of microbiota-gut-brain axis communication has been proposed to play a role in this association. In this systematic review and meta-analysis, we reviewed published articles that have presented results on changes in cognition, emotion, and behavior in rodents (rats and mice) after antibiotic-induced gut dysbiosis. We searched three databases—PubMed, Web of Science, and SCOPUS to identify such articles using dedicated search strings and extracted data from 48 articles. Increase in anxiety and depression-like behavior was reported in 32.7 and 40.7 percent of the …

Antibiotic-Induced Gut Dysbiosis And Cognitive, Emotional, And Behavioral Changes In Rodents: A Systematic Review And Meta-Analysis, Shivdeep S. Hayer, Soonjo Hwang, Jonathan B. Clayton

Food for Health: Publications

There are previous epidemiological studies reporting associations between antibiotic use and psychiatric symptoms. Antibiotic-induced gut dysbiosis and alteration of microbiota-gut-brain axis communication has been proposed to play a role in this association. In this systematic review and meta-analysis, we reviewed published articles that have presented results on changes in cognition, emotion, and behavior in rodents (rats and mice) after antibiotic-induced gut dysbiosis. We searched three databases—PubMed, Web of Science, and SCOPUS to identify such articles using dedicated search strings and extracted data from 48 articles. Increase in anxiety and depression-like behavior was reported in 32.7 and 40.7 percent of the …

Burnout And Its Impact On Nurses And Doctors, Zahra Tharani, Abeer Musaddique, Syeda Humera Qutb

School of Nursing & Midwifery

No abstract provided.

Neuro-Palliative Medicine, Shazia Faiz

Pakistan Journal of Neurological Sciences (PJNS)

No abstract provided.

State Capacity And Hiv Incidence Reduction In The Developing World: Preliminary Empirical Evidence, Andrew Price-Smith, Steven Tauber, Anand Bhat

Journal of Diplomacy and International Relations

No abstract provided.

A Quantitative Study Of Perceived Fitness And Nutrition Levels Of Secondary Educators In Relation To Their Overall Job Satisfaction Program At A Private Midwestern University, Jessica Arico

Dissertations

The profession of education traditionally embodies an idea of educating children on math, science, social studies, and English along with other elective course areas. In recent decades, however, the burnout rates and mental health of educators have become a subject of media attention and the basis for many new professional development programs. The one element wholly ignored in this space is the physiological wellbeing of educators and the impact physical health has on mental health and job satisfaction. This study set out to provide a baseline for beginning the discussion and future research on the physiological impact on educators and …

Western Australian Sheep Producer Survey 2022, Janet Conte, Katherine Davies

Animal production and livestock published reports

The Western Australian Sheep Producer Survey is conducted to gather information on sheep enterprises and producer practices. It has now been conducted four times, in 2011, 2014, 2018 and 2022 with large random samples of sheep producers in the Medium Rainfall Zone (MRZ) and Cereal Sheep Zone (CSZ).

Some questions were included in all four surveys providing a chance to examine trends over time. Many of the results have remained stable over time giving some confidence that significant changes in survey responses are reflecting trends in the broader population of WA sheep producers.

Mentor Holding Behaviours: The Role Of Supervisors And Effects On Protégés, Menzhong Gao

Dissertations and Theses Collection (Open Access)

The concept of holding behaviours has emerged as a response to the paradox that arises when employees require support but organisations face challenges in providing it. In today’s workplaces, job demands and organisational uncertainty have escalated, rendering traditional, hierarchical support systems inadequate to alleviate anxiety. Holding environments offer a temporary safe space for employees to express emotions and cope with uncertainty and insecurity.

Despite the importance of holding behaviours in addressing self-reliance and support dilemmas, limited research has been conducted on their antecedents, consequences, mechanisms, and boundary conditions. To fill this gap, this study proposes a trickle-down model that integrates …

Explaining Students’ Attitudes Towards A Sustainable Future: Evidence From Sea-Plm 2019 Data, Syeda Kashfee Ahmed, Petra Lietz

Global education monitoring

This report, published by the Global Education Monitoring (GEM) Centre, discusses how students’ attitudes towards global issues are now crucial more than ever to build a sustainable world for future generations. The first section describes why students’ attitudes towards school and learning are important and how they are linked to the Educational Prosperity Framework (Willms & Tramonte, 2015). The second section highlights the literature about the key factors which can influence students’ attitudes towards school and learning and how they are related to students’ attitudes towards sustainable development. The third section discusses the methods used for analysing the relationships between …

Protective Effect Of Fenugreek Supplementation Against Mercury Toxicity On Sperm Parameters, Serum Testosterone And Testicular Tissue In The Rat, Jalal A. Karim, Karim R. Hamad

Polytechnic Journal

Background and objectives:The purpose of the current study was to investigate the effects of fenugreek supplementation against toxic effect of mercuric chloride (HgCl2)on Body weight (B.W), testis and epididymis weight, some sperm parameters, serum testosterone, serum MDA, and testis histology in the rat.Methods: Twenty eight male albino rats weights ranging from 254 to 302 gm and were divided randomly and equally into 4 groups. Group I: control, Group II: Rats received drinking water contained HgCl2 100 mg/L ad libitum, Group III: Rats received drinking water contained HgCl2 100 mg/L ad libitum, and fenugreek (F1) 0.75 mg/kg/day orally by gavage, Group …

Deserting Desert Desserts: How Abandoning Outdated Buffet-Style Restaurants Could Aide In Nevada’S Statewide Ghg-Emission Reduction Goals, Emily Espinosa

UNLV Gaming Law Journal

No abstract provided.

The Personalized Acne Treatment Tool - Recommendations To Facilitate A Patient-Centered Approach To Acne Management From The Personalizing Acne: Consensus Of Experts, Alison M. Layton, Andrew Alexis, Hilary Baldwin, Vincenzo Bettoli, James Del Rosso, Thomas Dirschka, Brigitte Dréno, Linda F. Stein Gold, Julie Harper, Joo Yeon Ko, Khaled Al Nuaimi, Hazel H Oon, Murlidhar Rajagopalan, Marco Rocha, Jo-Ann See, Jonathan Weiss, Jerry Tan

Dermatology Articles

BACKGROUND: Acne, a commonly treated skin disease, requires patient-centered management due to its varying presentations, chronicity, and impact on health-related quality of life. Despite this, evidence-based clinical guidelines focus primarily on clinical severity of facial acne, omitting important patient- and disease-related factors, including ongoing management.

OBJECTIVES: To generate recommendations to support patient-centered acne management, which incorporate priority and prognostic factors beyond conventional clinical severity, traditionally defined by grading the appearance and extent of visible lesions.

METHODS: The Personalizing Acne: Consensus of Experts consisted of 17 dermatologists who used a modified Delphi approach to reach consensus on statements regarding patient- and …

Pulmonary & Critical Care Insider: Issue 2, Bharat Bajantri Md, Sarah Ellsworth Mls

Critical Care & Pulmonary

Pulmonary & Critical Care Insider Issue 2

Compiled by Bharat Bajantri, MD, and librarian Sarah Ellsworth, MLS for the clinicians of the Pulmonary and Critical Care team of Parkview.

The goal of this newsletter is to give a brief summary of the most pertinent articles to everyday practice and an attempt to keep up with literature as best as possible. Newsletters go out every 1-2 months.

Summaries/Topics in this issue:

• Spontaneous Breathing Trials
• Enteral feedings
• EFFORT Protein trial
• The NUTRIREA-3 trial
• Veno-venous extracorporeal carbon dioxide removal (vv-ECCO2 R)
• Acute hypoxemic respiratory failure (AHRF)
• Penicillin allergy
• PEN-FAST score
• Etomidate increases mortality …

Adolescent Hope And Optimism: A Scoping Review Of Measures And Their Psychometric Properties, Esther Chongwo, Ezra Too, Adam Mabrouk, Amina Abubakar

Institute for Human Development, East Africa

There is much research examining adolescent hope and optimism, but there is limited information on the available measures, particularly the most frequently used measures and their psychometric properties. We conducted a scoping review to: (1) identify measures of hope and optimism for use among adolescents; (2) determine the most frequently used measures of adolescent hope and optimism; (3) document the psychometric properties of the identified measures. We searched five bibliographic databases and Open Grey for relevant articles published from database inception to 03 May 2023. The search included the key terms ‘adolescents’, ‘optimism’, ‘hope’ and ‘measures’. We targeted adolescents aged …

Dousing The Flame: Reviewing The Mechanisms Of Inflammatory Programming During Stress-Induced Intrauterine Growth Restriction And The Potential For Ω-3 Polyunsaturated Fatty Acid Intervention, Melanie White, Dustin T. Yates

Department of Animal Science: Faculty Publications

Intrauterine growth restriction (IUGR) arises when maternal stressors coincide with peak placental development, leading to placental insufficiency. When the expanding nutrient demands of the growing fetus subsequently exceed the capacity of the stunted placenta, fetal hypoxemia and hypoglycemia result. Poor fetal nutrient status stimulates greater release of inflammatory cytokines and catecholamines, which in turn lead to thrifty growth and metabolic programming that benefits fetal survival but is maladaptive after birth. Specifically, some IUGR fetal tissues develop enriched expression of inflammatory cytokine receptors and other signaling cascade components, which increases inflammatory sensitivity even when circulating inflammatory cytokines are no longer elevated …

Differences In Internalized Weight Stigma And The Treatment Of Clients In Larger Bodies Among Mental Health And Medical Professionals, Alexis Dosal

Dissertations

Weight is a complex interaction of several factors, including genetics, environment, adverse childhood experiences, culture, physiology, and emotional circumstances (Hale, 2019). By solely considering the categories of food consumption and individual activity, the belief of personal responsibility and controllability is perpetuated, which may lead to intentional or unintentional harm within interpersonal interactions and throughout medical services (Nutter et al., 2020). Weight bias refers to “stereotypes, negative attitudes, and discriminatory behavior toward individuals with larger bodies” (Nutter et al., 2020). Weight bias can be displayed as discomfort around those in larger bodies, holding beliefs that fat people are lazy or unattractive, …

Renin As A Biomarker Of Acute Kidney Injury And Mortality In Children With Severe Malaria Or Sickle Cell Disease, Daniel Adan, Anthony Batte, Ruth Namazzi, Ivan Mufumba, Caroline Kazinga, Kagan Mellencamp, Caitlin Bond, Robert Opoka, Chandy John, Andrea Conroy

Paediatrics and Child Health, East Africa

Background: Globally, a very high percentage of acute kidney injury (AKI) occurs in low- and middle-income countries (LMICs) where late recognition contributes to increased mortality. There are challenges with using existing biomarkers of AKI in LMICs. Emerging evidence suggests renin may serve as a biomarker of kidney injury that can overcome limitations in creatinine-based diagnostics.

Methods: Two study populations in Uganda were assessed. Cohort #1 was a two-site, prospective cohort study enrolling 600 children with severe malaria (SM). Cohort #2 was a prospective cohort study enrolling 185 children with sickle cell disease (SCD) hospitalized with a vaso-occlusive crisis. Plasma or …

Serum Sulfur-Containing Amino Acids And Risk Of Maternal Gestational Diabetes And Adverse Growth Patterns In Offspring, Ninghua Li, Jing Li, Hui Wang, Yijuan Qiao, Weiqin Li, Ming Gao, Enqing Liu, Zhijie Yu, Gang Hu, Zhongze Fang, Junhong Leng, Xilin Yang

Population and Public Health Science Faculty Publications

Background: To estimate associations of sulfur-containing amino acids (SAAs) in the early trimester of pregnancy and gestational diabetes mellitus (GDM) and estimate associations of maternal SAAs with adverse growth patterns in offspring. Methods: We established a 1:1 matched case-control study (n = 486) from our cohort of pregnant women, and 401 children were followed up at ages 1 to 8 years. We conducted binary conditional logistic regression to estimate the risk associations of serum SAAs with GDM. Multinomial logistic regression was implemented to explore associations of maternal SAAs with adverse growth patterns in the offspring. Results: High serum methionine and …

New Frontiers In The Measurement Of Energy Metabolism, Alexandra Niclou, Philippe St-Martin, Leanne M. Redman, Audrey Bergouignan

Clinical Research Faculty Publications

This perspective highlights three key areas of current and future energy metabolism research: intergenerational health, climate change, and interplanetary exploration. We describe the recent advances in determining estimated energy requirements for a large subset of the general population using the gold standard method for free-living total daily energy expenditure estimates, the doubly labeled water method. The global rise in overweight and obesity demands particular attention to energy requirements in pregnancy and early life, as accumulating evidence contributes to our understanding of intergenerational health transmission and the potential for epigenetic programming in utero. We also acknowledge some gaps in necessary guidelines …

Field Evaluations Of The Cropmanage Decision Support Tool For Improving Irrigation And Nutrient Use Of Cool Season Vegetables In California, Michael Cahn, Richard Smith, Forrest Melton

AES Faculty Publications and Presentations

Vegetable growers on the central coast of California are under regulatory pressure to reduce nitrate loading to ground and surface water supplies. California also implemented legislation that limits agricultural pumping in regions such as the central coast where the aquifers have been over-extracted for crop irrigation. Growers could potentially use less N fertilizer, address water quality concerns, and conserve water by improving water management and matching nitrogen applications to the N uptake pattern of their crops. Two tools available to growers, the soil nitrate quick test (SNQT) and reference evapotranspiration (ETo) data have been previously shown to improve the management …

Experimented With Watercolor Painting (Summer 2023), Erin Cromeans

Staff Residencies

Erin Cromeans is the Associate Director of Strategic Initiatives and Outreach at the Institute of Child Nutrition.

Exercise-Induced Changes To The Fiber Type-Specific Redox State In Human Skeletal Muscle Are Associated With Aerobic Capacity, James Shadiow, Edwin R. Miranda, Ryan K. Perkins, Corey E. Mazo, Zhen Lin, Kendell N. Lewis, Jacob T. Mey, Thomas P.J. Solomon, Jacob M. Haus

Division of Basic Science Faculty Publications

The benefits of exercise involve skeletal muscle redox state alterations of nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD). We determined the fiber-specific effects of acute exercise on the skeletal muscle redox state in healthy adults. Muscle biopsies were obtained from 19 participants (11 M, 8 F; 26 ± 4 yr) at baseline (fasted) and 30 min and 3 h after treadmill exercise at 80% maximal oxygen consumption (V O2max). Muscle samples were probed for autofluorescence of NADH (excitation at 340-360 nm) and oxidized flavoproteins (Fp; excitation at 440-470 nm) and subsequently, fiber typed to quantify the redox signatures …

Guidelines For Parenteral Nutrition In Preterm Infants: The American Society For Parenteral And Enteral Nutrition, Daniel T. Robinson, Kara L. Calkins, Yimin Chen, M. Petrea Cober, Gustave H. Falciglia, David D. Church, Jacob Mey, Liam Mckeever, Timothy Sentongo

Division of Basic Science Faculty Publications

Background: Parenteral nutrition (PN) is prescribed for preterm infants until nutrition needs are met via the enteral route, but unanswered questions remain regarding PN best practices in this population. Methods: An interdisciplinary committee was assembled to answer 12 questions concerning the provision of PN to preterm infants. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) process was used. Questions addressed parenteral macronutrient doses, lipid injectable emulsion (ILE) composition, and clinically relevant outcomes, including PNALD, early childhood growth, and neurodevelopment. Preterm infants with congenital gastrointestinal disorders or infants already diagnosed with necrotizing enterocolitis or PN-associated liver disease (PNALD) at study …

Reduced Postabsorptive Interoception Of Nutrients In Obesity: Cause Or Consequence?, Hans Rudolf Berthoud

Division of Basic Science Faculty Publications

No abstract provided.

Initial Weight Loss And Early Intervention Adherence Predict Long-Term Weight Loss During The Promoting Successful Weight Loss In Primary Care In Louisiana Lifestyle Intervention, Christoph Höchsmann, Corby K. Martin, John W. Apolzan, James L. Dorling, Robert L. Newton, Kara D. Denstel, Emily F. Mire, William D. Johnson, Dachuan Zhang, Connie L. Arnold, Terry C. Davis, Vivian Fonseca, Tina K. Thethi, Carl J. Lavie, Benjamin Springgate, Peter T. Katzmarzyk

Clinical Research Faculty Publications

Objective: This study tested whether initial weight change (WC), self-weighing, and adherence to the expected WC trajectory predict longer-term WC in an underserved primary-care population with obesity. Methods: Data from the intervention group (n = 452; 88% women; 74% Black; BMI 37.3 kg/m2 [SD: 4.6]) of the Promoting Successful Weight Loss in Primary Care in Louisiana trial were analyzed. Initial (2-, 4-, and 8-week) percentage WC was calculated from baseline clinic weights and daily at-home weights. Weights were considered adherent if they were on the expected WC trajectory (10% at 6 months with lower [7.5%] and upper [12.5%] bounds). Linear …

The Type 1 Diabetes And Exercise Initiative: Predicting Hypoglycemia Risk During Exercise For Participants With Type 1 Diabetes Using Repeated Measures Random Forest, Simon Bergford, Michael C. Riddell, Peter G. Jacobs, Zoey Li, Robin L. Gal, Mark A. Clements, Francis J. Doyle, Corby K. Martin, Susana R. Patton, Jessica R. Castle, Melanie B. Gillingham, Roy W. Beck, Michael R. Rickels, Peter Calhoun

Clinical Research Faculty Publications

Objective: Exercise is known to increase the risk for hypoglycemia in type 1 diabetes (T1D) but predicting when it may occur remains a major challenge. The objective of this study was to develop a hypoglycemia prediction model based on a large real-world study of exercise in T1D. Research Design and Methods: Structured study-specified exercise (aerobic, interval, and resistance training videos) and free-living exercise sessions from the T1D Exercise Initiative study were used to build a model for predicting hypoglycemia, a continuous glucose monitoring value < 70 mg/dL, during exercise. Repeated measures random forest (RMRF) and repeated measures logistic regression (RMLR) models were constructed to predict hypoglycemia using predictors at the start of exercise and baseline characteristics. Models were evaluated with area under the receiver operating characteristic curve (AUC) and balanced accuracy. Results: RMRF and RMLR had similar AUC (0.833 vs. 0.825, respectively) and both models had a balanced accuracy of 77%. The probability of hypoglycemia was higher for exercise sessions with lower pre-exercise glucose levels, negative pre-exercise glucose rates of change, greater percent time < 70 mg/dL in the 24 h before exercise, and greater pre-exercise bolus insulin-on-board (IOB). Free-living aerobic exercises, walking/hiking, and physical labor had the highest probability of hypoglycemia, while structured exercises had the lowest probability of hypoglycemia. Conclusions: RMRF and RMLR accurately predict hypoglycemia during exercise and identify factors that increase the risk of hypoglycemia. Lower glucose, decreasing levels of glucose before exercise, and greater pre-exercise IOB largely predict hypoglycemia risk in adults with T1D.

Sarcopenic Obesity: Emerging Mechanisms And Therapeutic Potential, Christopher L. Axelrod, Wagner S. Dantas, John P. Kirwan

Division of Basic Science Faculty Publications

Sarcopenic obesity, or the loss of muscle mass and function associated with excess adiposity, is a largely untreatable medical condition associated with diminished quality of life and increased risk of mortality. To date, it remains somewhat paradoxical and mechanistically undefined as to why a subset of adults with obesity develop muscular decline, an anabolic stimulus generally associated with retention of lean mass. Here, we review evidence surrounding the definition, etiology, and treatment of sarcopenic obesity with an emphasis on emerging regulatory nodes with therapeutic potential. We review the available clinical evidence largely focused on diet, lifestyle, and behavioral interventions to …

Global Rural Health Disparities In Alzheimer's Disease And Related Dementias: State Of The Science, Lisa Ann Kirk Wiese, Allison Gibson, Marc Aaron Guest, Amy R. Nelson, Raven Weaver, Aditi Gupta, Owen Carmichael, Jordan P. Lewis, Allison Lindauer, Samantha Loi, Rachel Peterson, Kylie Radford, Elizabeth K. Rhodus, Christina G. Wong, Megan Zuelsdorff, Ladan Ghazi Saidi, Esmeralda Valdivieso-Mora, Sanne Franzen, Caitlin N. Pope, Timothy S. Killian, Hom L. Shrestha, Patricia C. Heyn, Ted Kheng Siang Ng, Beth Prusaczyk, Samantha John, Ambar Kulshreshtha, Julia L. Sheffler, Lilah Besser, Valerie Daniel, Magdalena I. Tolea, Justin Miller, Christine Musyimi, Jon Corkey, Veronica Yank

Clinical Research Faculty Publications

INTRODUCTION: Individuals living in rural communities are at heightened risk for Alzheimer's disease and related dementias (ADRD), which parallels other persistent place-based health disparities. Identifying multiple potentially modifiable risk factors specific to rural areas that contribute to ADRD is an essential first step in understanding the complex interplay between various barriers and facilitators. METHODS: An interdisciplinary, international group of ADRD researchers convened to address the overarching question of: “What can be done to begin minimizing the rural health disparities that contribute uniquely to ADRD?” In this state of the science appraisal, we explore what is known about the biological, behavioral, …

Probiotic Characteristics Of Streptococcus Thermophilus And Lactobacillus Bulgaricus As Influenced By New Food Sources, Ashly Castro, Ricardo S. Aleman, Miguel Tabora, Shirin Kazemzadeh, Leyla K. Pournaki, Roberto Cedillos, Jhunior Marcia, Kayanush Aryana

Faculty Publications

The current research aimed to evaluate the potential effects of Solanum mammosum, Dioon mejiae, and Amanita caesarea on Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus survival and performance after exposure to different harsh conditions such as bile, acid, gastric juice, and lysozyme to mimic the digestive system from mouth to the intestine. Probiotic protease activity was observed to evaluate the proteolytic system. Probiotics were cultured in a broth mixed with plant material, and after incubation, the results were compared to the control sample. Therefore, plant material’s total phenolic compound, total carotenoid compound, antioxidant activity, sugar profile, and acid profile were …

Effects Of Weevil (Rhynchophorus Palmarum), Teosinte (Dioon Mejiae) And Caesar’S Mushroom (Amanita Caesarea) On The Properties Of Lactobacillus Acidophilus La-K, Ricardo S. Aleman, Dany Avila, Allan Avila, Jhunior Marcia, David Picha, Kayanush Aryana, Ismael Montero-Fernández

Faculty Publications

Weevil (Rhynchophorus palmarum) powder, teosinte (Dioon mejiae) and Caesar’s mushroom (Amanita caesarea) flour have bioactive compounds with significant nutritional applications. This paper aimed to examine the influence of weevil, teosinte, and mushroom powders on the protease activity, acid tolerance, bile tolerance, lysozyme tolerance, and gastric juice resistance ability of Lactobacillus acidophilus LA-K. Acid tolerance was determined by adjusting the pH of MRS broth to 2.0 for L. acidophilus incubated under aerobic conditions at 37 °C. Bile tolerance was determined by incorporating 0.3% of oxgall. Protease activity was determined spectrophotometrically at 340 nm. Resistance to 100 mg/L of lysozyme in an …