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2023

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Diversity Of The Gut Microbiome Of Chicken Fed With Black Soldier Fly Larvae -Based Feeds, Evalyne Wambui Ndotono Jan 2023

Diversity Of The Gut Microbiome Of Chicken Fed With Black Soldier Fly Larvae -Based Feeds, Evalyne Wambui Ndotono

All Master’s Theses

Industrial rearing of insects, especially the black soldier fly, is gaining momentum in recent years because of the increase in food and feed insecurity, high prices of animal feeds and animal proteins, and population growth. This in turn has led to increased global demand for alternative sources of protein apart from traditional livestock products. This study focused on evaluating the gut microbial community dynamics of both the layer and broiler chickens that have been fed on BSF larvae-based diet. The bacterial communities were characterized using high throughput Oxford nanopore sequencing of the full-length bacterial 16S rRNA gene and downstream analysis …


Assesment Of The Nutritional Value, Microbial Quality And Sensory Acceptance Of Cookies Enriched With Edible Longhorn Grasshoper (Ruspolia Differens Serville) Flours From Different Processing Methods, Brian Onyango Ochieng Jan 2023

Assesment Of The Nutritional Value, Microbial Quality And Sensory Acceptance Of Cookies Enriched With Edible Longhorn Grasshoper (Ruspolia Differens Serville) Flours From Different Processing Methods, Brian Onyango Ochieng

All Master’s Theses

Long-horned grasshopper (Ruspolia differens), an edible insect native to sub-Saharan Africa, is considered a delicacy by some communities in the region and contributes 5-10% of the protein intake. However, its full utilization as food across the different cultural constructs has been hampered by neophobia and disgust occasioned by uncommon food cultural practices, thereby limiting its potential to combat malnutrition in the region. Therefore, there is need to process and hide the insect into modern food products to improve its utilization. The current study investigated the effects of enriching cookies with differently processed R. differens flours on the nutritional composition, digestibility …


Feeling Connected: Examining The Importance Of Human Connection On The Personal Outlook Of Social Service Providers Working With The Homeless During The Covid-19 Pandemic, Darci M. Graves, Ines W. Jindra, Nicholas Evans Jan 2023

Feeling Connected: Examining The Importance Of Human Connection On The Personal Outlook Of Social Service Providers Working With The Homeless During The Covid-19 Pandemic, Darci M. Graves, Ines W. Jindra, Nicholas Evans

Journal of Human Services: Training, Research, and Practice

Abstract

This research study explores the lived experiences of social workers and social service providers (collectively referred to as ‘providers’) working with the homeless and homeless-adjacent populations in the early phases of the COVID-19 pandemic. We examine how the pandemic changed the work providers do, and how providers coped with and adapted to these changes. This research utilizes traditional qualitative interviews with a total of twenty providers located in the North-Western United States (NW-US). Key findings from this research indicate providers' outcomes were influenced by the extent of their social connections to community, clients, and coworkers throughout the pandemic. This …


Ecuadorian Gravel Pack Spring Water Intakes, Derek Ten Pas, Julie Wildschut, Robert Hoeksema, Bruce Rydbeck, Chris Visscher Jan 2023

Ecuadorian Gravel Pack Spring Water Intakes, Derek Ten Pas, Julie Wildschut, Robert Hoeksema, Bruce Rydbeck, Chris Visscher

University Faculty Publications and Creative Works

This paper describes the basic design concept to design and build a type of spring water intake. The spring protection method bears similarity to a gravel pack well albeit constructed horizontally rather than the vertical construction of a gravel pack well. The design approach includes:

  • collection of spring water subterranean using the aquifer and surrounding soil to filter the water supply,
  • use of gravel pack to retain the surrounding aquifer materials and soil structure in place while providing an easy flow path for water to enter a slotted collector pipe and flow to a receiving tank without impounding spring water, …


Amending The Defense Production Act: Preventing Another Pandemic, Madalyn Mcgunagle Jan 2023

Amending The Defense Production Act: Preventing Another Pandemic, Madalyn Mcgunagle

Roger Williams University Law Review

No abstract provided.


Effect Of Different Light Intensities And Colors On Growth Performance And Reproductive Characteristics In Japanese Quails, Fawwad Ahmad, Muhammad Sharif, Muhammad Ashraf, Muhammad Riaz, Muhammad Shoaib, Talha Siddique, Aqian Ahmed, Ahmad Hamad Sheir, Muhammad Ahsan Yaseen, Muhammad Mahboob Ali Hamid Jan 2023

Effect Of Different Light Intensities And Colors On Growth Performance And Reproductive Characteristics In Japanese Quails, Fawwad Ahmad, Muhammad Sharif, Muhammad Ashraf, Muhammad Riaz, Muhammad Shoaib, Talha Siddique, Aqian Ahmed, Ahmad Hamad Sheir, Muhammad Ahsan Yaseen, Muhammad Mahboob Ali Hamid

Turkish Journal of Veterinary & Animal Sciences

Light is one of the most important environmental factors in quail farming, as it has a significant impact on production efficiency and reproductive characteristics. The purpose of this study was to determine the effect of different light intensities and colors on production performance in Japanese quails. For the first experiment, 200 Japanese quails were divided into five treatment groups, each with four replicates (10 birds in each). The birds in the control treatment were exposed to a light intensity of 20 lux, while the other four treatment groups were exposed to light intensities of 10 lux, 15 lux, 25 lux, …


Investigation Of Bmp15 And Gdf9 Gene Polymorphisms And Their Effects On Litter Size In Anatolian Sheep Breed Akkaraman, Koray Kirikçi Jan 2023

Investigation Of Bmp15 And Gdf9 Gene Polymorphisms And Their Effects On Litter Size In Anatolian Sheep Breed Akkaraman, Koray Kirikçi

Turkish Journal of Veterinary & Animal Sciences

This study aimed to examine the polymorphism of the BMP15 (FecX$^{G}$ and FecX$^{I}$) and GDF9 (G1 and G4) genes and the association between genotypes and litter size in the Akkaraman breed. Blood samples were taken from 100 ewes in total. Genomic DNA was obtained from whole blood. The PCR-RFLP technique was employed to determine the polymorphisms of the genes under investigation. The G1 was the only polymorphic among the four loci analyzed. The frequencies for the GA and GG genotypes were 0.26 and 0.74, respectively, while the A and G allele frequencies were 0.13 and 0.87, respectively. The observed and …


Influence Of Lactobacillus Plantarum Administration On Some Serum/Tissue (Uterus) Antioxidant And Cytokine Levels In Female Rats Exposed To Cadmium (Cd), İhsan Kisadere, Bariş Güner, Hakan Tavşanli, Mehmet Faruk Aydin, Mustafa Usta Jan 2023

Influence Of Lactobacillus Plantarum Administration On Some Serum/Tissue (Uterus) Antioxidant And Cytokine Levels In Female Rats Exposed To Cadmium (Cd), İhsan Kisadere, Bariş Güner, Hakan Tavşanli, Mehmet Faruk Aydin, Mustafa Usta

Turkish Journal of Veterinary & Animal Sciences

The study aimed to investigate the effects of oral Lactobacillus plantarum (Lp) administration on some serum/tissue (uterus) antioxidant and cytokine levels as well as histopathologic changes in female rats exposed chronically to Cd. For this purpose, rats were separated into four groups including control (C, n = 8), cadmium (Cd, n = 8), Lp (n = 8), and Cd + Lp (n = 8). Cd (dissolved in water at a dose of 2.04 mg/mL) was orally administered to Cd and Cd + Lp groups for 28 days. Besides, active-live Lp, which was grown at a level of approximately 10$^{8}$-10$^{9}$ cfu/mL …


Could There Be A Relationship Between Feeding Characteristics And The Shape Of Condylus Occipitalis And Foramen Magnum In Mammals?, Yasi̇n Demi̇raslan, İsmai̇l Demi̇rci̇oğlu, İftar Gürbüz, Funda Aksünger Karaavci, Abdullah Ortadeveci, Özcan Özgel Jan 2023

Could There Be A Relationship Between Feeding Characteristics And The Shape Of Condylus Occipitalis And Foramen Magnum In Mammals?, Yasi̇n Demi̇raslan, İsmai̇l Demi̇rci̇oğlu, İftar Gürbüz, Funda Aksünger Karaavci, Abdullah Ortadeveci, Özcan Özgel

Turkish Journal of Veterinary & Animal Sciences

The aim of the study was to investigate the shape of the foramen magnum and condylus occipitalis of mammalian species belonging to different feeding groups. For this, two-dimensional geometric morphometric method analyses were applied. The data from the skulls of the 12 species were used. In principal component analysis, the first three principal components accounted for 70.353%of the total shape variation. According to the first principal component, the dorsal edge of the condylus occipitalis and foramen magnum contributed the most to shape variation. Most of the individuals were correctly separated according to the feeding groups. The most accurate grouping features …


Understanding Cancer Patients' Desire To Quit Tobacco Without Assistance: A Mixed-Methods, Longitudinal Study, Tia Borger Jan 2023

Understanding Cancer Patients' Desire To Quit Tobacco Without Assistance: A Mixed-Methods, Longitudinal Study, Tia Borger

Theses and Dissertations--Psychology

Introduction: Unassisted attempts to quit tobacco are a well-established reason for quit failure. Nonetheless, many cancer patients prefer to make a quit attempt without using evidence-based tobacco treatment. This study aimed to understand the rationale that underlies cancer patients’ desire to quit tobacco without assistance and to track longitudinally the smoking cessation outcomes of patients with this preference. Method: In a mixed-methods, longitudinal study, 35 cancer patients who were current tobacco users and declined tobacco treatment because of the desire to quit on their own provided data via three questionnaires and 1-2 semi-structured interviews across 60 days. Participants were recruited …


Elucidating The Role Of A Staphylococcal Glucosaminidase In Host Innate Immune Responses, Zachary Resko Jan 2023

Elucidating The Role Of A Staphylococcal Glucosaminidase In Host Innate Immune Responses, Zachary Resko

Dissertations

The peptidoglycan of Staphylococcus aureus is a critical cell envelope constituent and virulence factor that subverts host immune defenses and provides protection against environmental stressors. Peptidoglycan chains of the S. aureus cell wall are processed to characteristically short lengths by the glucosaminidase, SagB. It is well established that peptidoglycan is an important pathogen-associated molecular pattern (PAMP) that is recognized by the host innate immune system and promotes production of pro-inflammatory cytokines, including IL-1β. However, how bacterial processing of peptidoglycan drives IL-1β production is comparatively unexplored. Here, we tested the involvement of staphylococcal glucosaminidases in shaping innate immune responses and identified …


The Impact Of Covid-19 Quarantine On Lifestyle Indicators In The United Arab Emirates, Sharifa Alblooshi, Maryam Alfalasi, Zainab Taha, Farid El Ktaibi, Alia Khalid Jan 2023

The Impact Of Covid-19 Quarantine On Lifestyle Indicators In The United Arab Emirates, Sharifa Alblooshi, Maryam Alfalasi, Zainab Taha, Farid El Ktaibi, Alia Khalid

All Works

Introduction: COVID-19 is a virus that has spread rapidly and brought economic and social crises all around the world. The current study aimed to investigate the impact of COVID-19 quarantine on dietary habits, physical activity, food purchasing, smoking, and sleeping patterns in the United Arab Emirates. Methods: A cross-sectional study was conducted using an online questionnaire between November 1st, 2020 and the end of January 2021. Citizens and residents of the UAE aged ≥ 18 years old were asked to complete an anonymous electronic questionnaire created via Google Forms and distributed on various platforms, such as WhatsApp, Twitter, and email. …


Clinical Education Innovation Enabled By Xr Space Medicine Technology, Ethan Waisberg, Joshua Ong, Phani Paladugu, Nasif Zaman, Sharif Amit Kamran, Andrew G. Lee, Alireza Tavakkoli Jan 2023

Clinical Education Innovation Enabled By Xr Space Medicine Technology, Ethan Waisberg, Joshua Ong, Phani Paladugu, Nasif Zaman, Sharif Amit Kamran, Andrew G. Lee, Alireza Tavakkoli

International Journal of Aviation, Aeronautics, and Aerospace

Head-mounted extended reality (XR) has emerged as a powerful tool in medical education for simulation of clinical and surgical situations. Another potentially powerful clinical tool of XR may be to help clinicians further understand disease from the patient’s perception. In our work to develop a training tool for astronauts undergoing interplanetary gravitational transitions, we identified a unique opportunity to also develop this emerging tool for clinicians specializing in vestibulo-ocular disease. By emulating patient perception of disease, this may increase understanding and clinical insight into clinical care in the future. This work is a component of a developing NASA-funded, head-mounted multimodal …


A Study Of Verbal Rumination, Relationships, Stress And Identity On Health Communication In Collegiate Athletics, Landon Mary Ellen Kemp Jan 2023

A Study Of Verbal Rumination, Relationships, Stress And Identity On Health Communication In Collegiate Athletics, Landon Mary Ellen Kemp

Dissertations and Theses

College athletes are a unique group of individuals as they face many positive and negative challenges when competing in a collegiate sport. Verbal rumination is repetitive talk about a particular issue, accompanied by adverse effects for an individual. Verbal rumination is a common strategy athletes use to cope with difficulties along with managing challenging situations in their athletic program. To explore factors that might inspire or impede verbal rumination in collegiate athletics, the present study examines the quality of coach and teammate relationships, perceived stress and athlete identity. Results revealed the impact of relationships between coaches and athletes in respect …


Dietary Counselling Of Children With Food Allergy, Julia Eisenblaetter Jan 2023

Dietary Counselling Of Children With Food Allergy, Julia Eisenblaetter

School of Health Professions Theses

Background: The management of food allergy is challenging for children and their families. Several international guidelines recommend involving dietitians in the management; however, their tasks remain uncertain, and the effectiveness of dietary counselling has rarely been investigated. Therefore, the aim of this project was to evaluate the effectiveness of dietary counselling in children with food allergy regarding food allergy related quality of life (QoL), number of allergic reactions, and growth as indicator of nutritional status and diet diversity. Methods: The project was guided by the Complex Intervention Model by the Medical Research Council. To reach the overall aim there needed …


Core Outcomes For Refractory Childhood Epilepsy Treated With Ketogenic Diet Therapy: The Core-Kdt Study, Jen Carroll Jan 2023

Core Outcomes For Refractory Childhood Epilepsy Treated With Ketogenic Diet Therapy: The Core-Kdt Study, Jen Carroll

School of Health Professions Theses

Background: Ketogenic diet therapy can result in seizure and non-seizure related benefits for children with drug resistant epilepsy. However, clinical trials report a wide range of outcomes which makes evidence synthesis difficult and they do not adequately reflect parent views on important outcomes for their child. To address this, we established the first international parent, health professional and researcher consensus to develop a core outcome set - a minimum standardised set of outcomes that should be measured and reported. (COMET registration #1116). Methods: Ethical approval was granted (London-Surrey REC19/LO/1680). A scoping review and interviews with parents identified a comprehensive list …


Carbohydrates And Endurance Exercise: A Narrative Review Of A Food First Approach, Alireza Naderi, Nathan Gobbi, Ajmol Ali, Erfan Berjisian, Amin Hamidvand, Scott C. Forbes, Majid S. Koozehchian, Raci Karayigit, Bryan Saunders Jan 2023

Carbohydrates And Endurance Exercise: A Narrative Review Of A Food First Approach, Alireza Naderi, Nathan Gobbi, Ajmol Ali, Erfan Berjisian, Amin Hamidvand, Scott C. Forbes, Majid S. Koozehchian, Raci Karayigit, Bryan Saunders

Research, Publications & Creative Work

Carbohydrate (CHO) supplements such as bars, gels, drinks and powders have become ubiquitous as effective evidence-based CHO sources that improve endurance exercise performance. However, athletes are increasingly turning to more cost-effective ‘food-first’ approaches for CHO ingestion to improve exercise performance. Mixed CHO foods including cooked lentils, oats, honey, raisins, rice, and potatoes are all effective pre-exercise CHO food sources. Caution is advised when selecting some of these foods as a primary CHO source, as some athletes may be prone to gastrointestinal discomfort—especially regarding those foods where the quantities required for recommended CHO intake may be voluminous (e.g., potatoes). Palatability may …


Building Strength Versus Getting Lean: An Analysis Of The Gendered Nature Of Fitness In Crossfit, Barre, And Personal Training, Margaret M. Jones Jan 2023

Building Strength Versus Getting Lean: An Analysis Of The Gendered Nature Of Fitness In Crossfit, Barre, And Personal Training, Margaret M. Jones

Master's Theses

Like many industries in contemporary society, the fitness sector is heavily gendered, andthus needs to be examined as a sector that both creates and reinforces gendered bodies. Building on previous single-method studies, I utilized a multi-methods approach of ethnography and interviews to analyze organizational and individual experiences with gender and fitness. Using West and Zimmerman’s concept of “doing gender,” I analyzed fitness organizations as a setting where gender and inequality are actively reproduced. By analyzing three fitness organizations with different gendered audiences (a barre studio, a CrossFit gym, and a personal training facility) I looked at how gender and fitness …


Decolonizing A Settler Colonial State: How Canada And The United States Have Approached Investigations Into Indigenous Boarding And Residential Schools, Holly Jacobs Jan 2023

Decolonizing A Settler Colonial State: How Canada And The United States Have Approached Investigations Into Indigenous Boarding And Residential Schools, Holly Jacobs

Master's Theses

Indigenous boarding and residential schools were in use for over 100 years in both Canada and the United States. Grown from numerous policies aimed at assimilation, dispossession, and genocide of the Indigenous peoples of North America, these residential schools had a particular aim: to wipe away all cultural and familial ties of every individual and to replace them with beliefs and values of white settlers. Though the schools are no longer in operation, their legacy of erasure and pain continues to affect survivors, their descendants, and Indigenous communities across both nations. This thesis looks at what the federal governments of …


Fostering A High-Functioning Team In Cancer Care Using The 4r Oncology Model: Assessment In A Large Health System And A Blueprint For Other Institutions, Raymond Liu, Christine B Weldon, Elizabeth Linehan, Nancy Gordon, Thea Abbe, Marti Hennings, Henie James, Jed Katzel, Chun Ng, Megumi Tomita, Jeffrey B Velotta, Stephanie Ossowski, Lori C Sakoda, Sharon Likely Sprague, Anna Dowling, Kimberly Beringer, Arliene Ravelo, Elaine Yu, Julia R Trosman Jan 2023

Fostering A High-Functioning Team In Cancer Care Using The 4r Oncology Model: Assessment In A Large Health System And A Blueprint For Other Institutions, Raymond Liu, Christine B Weldon, Elizabeth Linehan, Nancy Gordon, Thea Abbe, Marti Hennings, Henie James, Jed Katzel, Chun Ng, Megumi Tomita, Jeffrey B Velotta, Stephanie Ossowski, Lori C Sakoda, Sharon Likely Sprague, Anna Dowling, Kimberly Beringer, Arliene Ravelo, Elaine Yu, Julia R Trosman

Faculty, Staff and Student Publications

PURPOSE: Delivering cancer care by high-functioning multidisciplinary teams promises to address care fragmentation, which threatens care quality, affects patient outcomes, and strains the oncology workforce. We assessed whether the 4R Oncology model for team-based interdependent care delivery and patient self-management affected team functioning in a large community-based health system.

METHODS: 4R was deployed at four locations in breast and lung cancers and assessed along four characteristics of high-functioning teams: recognition as a team internally and externally; commitment to an explicit shared goal; enablement of interdependent work to achieve the goal; and engagement in regular reflection to adapt objectives and processes. …


Interventional Gastroenterology In Oncology, Vaibhav Wadhwa, Nicole Patel, Dheera Grover, Faisal S Ali, Nirav Thosani Jan 2023

Interventional Gastroenterology In Oncology, Vaibhav Wadhwa, Nicole Patel, Dheera Grover, Faisal S Ali, Nirav Thosani

Faculty, Staff and Student Publications

Cancer is one of the foremost health problems worldwide and is among the leading causes of death in the United States. Gastrointestinal tract cancers account for almost one third of the cancer-related mortality globally, making it one of the deadliest groups of cancers. Early diagnosis and prompt management are key to preventing cancer-related morbidity and mortality. With advancements in technology and endoscopic techniques, endoscopy has become the core in diagnosis and management of gastrointestinal tract cancers. In this extensive review, the authors discuss the role endoscopy plays in early detection, diagnosis, and management of esophageal, gastric, colorectal, pancreatic, ampullary, biliary …


Proton Therapy With Concurrent Chemotherapy For Thoracic Esophageal Cancer: Toxicity, Disease Control, And Survival Outcomes, Michael S Rutenberg, Bradford S Hoppe, Jason S Starr, Ziad Awad, Mathew Thomas, Christopher G Morris, Perry Johnson, Randal H Henderson, Jeremy C Jones, Bharatsinh Gharia, Steven Bowers, Herbert C Wolfsen, Sunil Krishnan, Stephen J Ko, Hani M Babiker, Romaine C Nichols Jan 2023

Proton Therapy With Concurrent Chemotherapy For Thoracic Esophageal Cancer: Toxicity, Disease Control, And Survival Outcomes, Michael S Rutenberg, Bradford S Hoppe, Jason S Starr, Ziad Awad, Mathew Thomas, Christopher G Morris, Perry Johnson, Randal H Henderson, Jeremy C Jones, Bharatsinh Gharia, Steven Bowers, Herbert C Wolfsen, Sunil Krishnan, Stephen J Ko, Hani M Babiker, Romaine C Nichols

Faculty, Staff and Student Publications

PURPOSE: When treating esophageal cancer with radiation therapy, it is critical to limit the dose to surrounding structures, such as the lung and/or heart, as much as possible. Proton radiation therapy allows a reduced radiation dose to both the heart and lungs, potentially reducing the risk of cardiopulmonary toxicity. Here, we report disease control, survival, and toxicity outcomes among patients with esophageal cancer treated with proton radiation therapy and concurrent chemotherapy (chemoradiation therapy; CRT) with or without surgery.

MATERIALS AND METHODS: We enrolled 17 patients with thoracic esophageal carcinoma on a prospective registry between 2010 and 2021. Patients received proton …


Risk Prediction Of Pancreatic Cancer In Patients With Recent-Onset Hyperglycemia: A Machine-Learning Approach, Wansu Chen, Rebecca K Butler, Eva Lustigova, Suresh T Chari, Anirban Maitra, Jo A Rinaudo, Bechien U Wu Jan 2023

Risk Prediction Of Pancreatic Cancer In Patients With Recent-Onset Hyperglycemia: A Machine-Learning Approach, Wansu Chen, Rebecca K Butler, Eva Lustigova, Suresh T Chari, Anirban Maitra, Jo A Rinaudo, Bechien U Wu

Faculty, Staff and Student Publications

Background: New-onset diabetes (NOD) has been suggested as an early indicator of pancreatic cancer. However, the definition of NOD by the American Diabetes Association requires 2 simultaneous or consecutive elevated glycemic measures. We aimed to apply a machine-learning approach using electronic health records to predict the risk in patients with recent-onset hyperglycemia.

Materials and methods: In this retrospective cohort study, health plan enrollees 50 to 84 years of age who had an elevated (6.5%+) glycated hemoglobin (HbA1c) tested in January 2010 to September 2018 with recent-onset hyperglycemia were identified. A total of 102 potential predictors were extracted. Ten imputation datasets …


Editorial: Metabolic Regulation Under Oxidative Stress In Cancer, Elavarasan Subramani, Abishai Dominic, Pratip K Bhattacharya, Daniel E Frigo, Ilya Bederman, Ali Vaziri-Gohar Jan 2023

Editorial: Metabolic Regulation Under Oxidative Stress In Cancer, Elavarasan Subramani, Abishai Dominic, Pratip K Bhattacharya, Daniel E Frigo, Ilya Bederman, Ali Vaziri-Gohar

Faculty, Staff and Student Publications

Oxidative stress has emerged as a key component of cancer metabolism that impacts multiple facets of tumor biology (1). Recent studies have shed light on the complex interplay of cellular redox and its impact on molecular mechanisms that govern metabolic reprogramming under oxidative stress (2, 3). It is well established that altered glucose metabolism exhibited by tumor cells leads to an enormous oxidative burden through various metabolic routes (4, 5). What is less known but remains a great interest to the field is whether elevated oxidative stress has a causal role in …


Student-Led Health Promotion Toolkit: A Practice Development Project, R Reynolds, S Neill Jan 2023

Student-Led Health Promotion Toolkit: A Practice Development Project, R Reynolds, S Neill

School of Nursing and Midwifery

Student nurses are uniquely placed to contribute to health promotion during their undergraduate programmes. The aim of this practice development project was to co-develop a toolkit to facilitate student nurse led health promotion practice. The project used an emancipatory methodology to explore health promotion practice opportunities for one university cohort of student nurses in partnership with the local practice area. A person-centred framework was used to engage with students and nurses to benchmark current student practice, scope for student-led activity and develop a shared vision for the toolkit resources. The student questionnaire revealed greater confidence in health promotion knowledge than …


Pain Experience And Sensory Changes In Astronauts During And After Short-Lasting Commercial Spaceflight: A Proof-Of-Concept Study, Andrea K Sauer, Marie Vigouroux, Patrick M Dougherty, Juan Pablo Cata, Pablo M Ingelmo Jan 2023

Pain Experience And Sensory Changes In Astronauts During And After Short-Lasting Commercial Spaceflight: A Proof-Of-Concept Study, Andrea K Sauer, Marie Vigouroux, Patrick M Dougherty, Juan Pablo Cata, Pablo M Ingelmo

Faculty, Staff and Student Publications

Space travel has been associated with musculoskeletal pain, yet little is known about the nociceptive changes and pain experience during spaceflight. This preliminary study aims to investigate the pain experience and sensory alterations in astronauts following a 17-day mission to the International Space Station (ISS) on Axiom Space's AX-1 commercial space flight. Two participants were enrolled, and data were collected pre-flight, in-flight, post-flight, and three-month post-flight. Validated pain questionnaires assessed anxiety, catastrophizing, impact on physical and mental health, disability, and overall pain experience. Qualitative interviews were conducted post-landing and conditioned pain modulation (CPM) and quantitative sensory testing (QST) were performed. …


Circulating Vitamin D And Breast Cancer Risk: An International Pooling Project Of 17 Cohorts, Kala Visvanathan, Alison M Mondul, Anne Zeleniuch-Jacquotte, Molin Wang, Mitchell H Gail, Shiaw-Shyuan Yaun, Stephanie J Weinstein, Marjorie L Mccullough, A Heather Eliassen, Nancy R Cook, Claudia Agnoli, Martin Almquist, Amanda Black, Julie E Buring, Chu Chen, Yu Chen, Tess Clendenen, Laure Dossus, Veronika Fedirko, Gretchen L Gierach, Edward L Giovannucci, Gary E Goodman, Marc T Goodman, Pascal Guénel, Göran Hallmans, Susan E Hankinson, Ronald L Horst, Tao Hou, Wen-Yi Huang, Michael E Jones, Corrine E Joshu, Rudolf Kaaks, Vittorio Krogh, Tilman Kühn, Marina Kvaskoff, I-Min Lee, Yahya Mahamat-Saleh, Johan Malm, Jonas Manjer, Gertraud Maskarinec, Amy E Millen, Toqir K Mukhtar, Marian L Neuhouser, Trude E Robsahm, Minouk J Schoemaker, Sabina Sieri, Malin Sund, Anthony J Swerdlow, Cynthia A Thomson, Giske Ursin, Jean Wactawski-Wende, Ying Wang, Lynne R Wilkens, Yujie Wu, Emilie Zoltick, Walter C Willett, Stephanie A Smith-Warner, Regina G Ziegler Jan 2023

Circulating Vitamin D And Breast Cancer Risk: An International Pooling Project Of 17 Cohorts, Kala Visvanathan, Alison M Mondul, Anne Zeleniuch-Jacquotte, Molin Wang, Mitchell H Gail, Shiaw-Shyuan Yaun, Stephanie J Weinstein, Marjorie L Mccullough, A Heather Eliassen, Nancy R Cook, Claudia Agnoli, Martin Almquist, Amanda Black, Julie E Buring, Chu Chen, Yu Chen, Tess Clendenen, Laure Dossus, Veronika Fedirko, Gretchen L Gierach, Edward L Giovannucci, Gary E Goodman, Marc T Goodman, Pascal Guénel, Göran Hallmans, Susan E Hankinson, Ronald L Horst, Tao Hou, Wen-Yi Huang, Michael E Jones, Corrine E Joshu, Rudolf Kaaks, Vittorio Krogh, Tilman Kühn, Marina Kvaskoff, I-Min Lee, Yahya Mahamat-Saleh, Johan Malm, Jonas Manjer, Gertraud Maskarinec, Amy E Millen, Toqir K Mukhtar, Marian L Neuhouser, Trude E Robsahm, Minouk J Schoemaker, Sabina Sieri, Malin Sund, Anthony J Swerdlow, Cynthia A Thomson, Giske Ursin, Jean Wactawski-Wende, Ying Wang, Lynne R Wilkens, Yujie Wu, Emilie Zoltick, Walter C Willett, Stephanie A Smith-Warner, Regina G Ziegler

Faculty, Staff and Student Publications

Laboratory and animal research support a protective role for vitamin D in breast carcinogenesis, but epidemiologic studies have been inconclusive. To examine comprehensively the relationship of circulating 25-hydroxyvitamin D [25(OH)D] to subsequent breast cancer incidence, we harmonized and pooled participant-level data from 10 U.S. and 7 European prospective cohorts. Included were 10,484 invasive breast cancer cases and 12,953 matched controls. Median age (interdecile range) was 57 (42-68) years at blood collection and 63 (49-75) years at breast cancer diagnosis. Prediagnostic circulating 25(OH)D was either newly measured using a widely accepted immunoassay and laboratory or, if previously measured by the cohort, …


Hiatal Hernia Repair With Transoral Incisionless Fundoplication Versus Nissen Fundoplication For Gastroesophageal Reflux Disease: A Retrospective Study, Veeravich K Jaruvongvanich, Reem Matar, Janani Reisenauer, Peter Janu, Peter Mavrelis, Glenn Ihde, Michael Murray, Sneha Singh, Jennifer Kolb, Ninh T Nguyen, Nirav Thosani, Erik B Wilson, Rasa Zarnegar, Kenneth Chang, Marcia I Canto, Barham K Abu Dayyeh Jan 2023

Hiatal Hernia Repair With Transoral Incisionless Fundoplication Versus Nissen Fundoplication For Gastroesophageal Reflux Disease: A Retrospective Study, Veeravich K Jaruvongvanich, Reem Matar, Janani Reisenauer, Peter Janu, Peter Mavrelis, Glenn Ihde, Michael Murray, Sneha Singh, Jennifer Kolb, Ninh T Nguyen, Nirav Thosani, Erik B Wilson, Rasa Zarnegar, Kenneth Chang, Marcia I Canto, Barham K Abu Dayyeh

Faculty, Staff and Student Publications

Background and study aims  Concomitant hiatal hernia (HH) repair with transoral incisionless fundoplication (TIF) is a therapeutic option for patients with HH > 2 cm and gastroesophageal reflux disease (GERD). Data comparing this approach with laparoscopic Nissen fundoplication (LNF) are lacking. We performed an exploratory analysis to compare these two approaches' adverse events (AEs) and clinical outcomes.

Patients and methods  This was a multicenter retrospective cohort study of HH repair followed by LNF versus HH repair followed by TIF in patients with GERD and moderate HH (2–5 cm). AEs were assessed using the Clavien-Dindo classification. Symptoms (heartburn/regurgitation, bloating, and dysphagia) were …


Molecular Mechanisms Of Osteosarcoma Metastasis And Possible Treatment Opportunities, Xinhui Du, Hua Wei, Boya Zhang, Bangmin Wang, Zhehuang Li, Lon Kai Pang, Ruiying Zhao, Weitao Yao Jan 2023

Molecular Mechanisms Of Osteosarcoma Metastasis And Possible Treatment Opportunities, Xinhui Du, Hua Wei, Boya Zhang, Bangmin Wang, Zhehuang Li, Lon Kai Pang, Ruiying Zhao, Weitao Yao

Faculty, Staff and Student Publications

In osteosarcoma patients, metastasis of the primary cancer is the leading cause of death. At present, management options to prevent metastasis are limited and non-curative. In this study, we review the current state of knowledge on the molecular mechanisms of metastasis and discuss promising new therapies to combat osteosarcoma metastasis. Genomic and epigenomic changes, metabolic reprogramming, transcription factors, dysregulation of physiologic pathways, and alterations to the tumor microenvironment are some of the changes reportedly involved in the regulation of osteosarcoma metastasis. Key factors within the tumor microenvironment include infiltrating lymphocytes, macrophages, cancer-associated fibroblasts, platelets, and extracellular components such as vesicles, …


Peripheral Vascular Access As Exclusive Access Mode In Pediatric Intensive Care Unit, Sonya Hayes Armstrong, Shantaveer Gangu, Alina Nico West, Thomas Spentzas Jan 2023

Peripheral Vascular Access As Exclusive Access Mode In Pediatric Intensive Care Unit, Sonya Hayes Armstrong, Shantaveer Gangu, Alina Nico West, Thomas Spentzas

Faculty, Staff and Student Publications

INTRODUCTION: The type of vascular access (central or peripheral) in pediatric critical care depends on several factors, including the duration of treatment, the properties of the medication (osmolarity or vesicant), and the need for central pressure monitoring. The utilization of peripheral intravascular catheters (PIVCs) has shown a notable increase in the number of patients being treated. Extended dwell or midline catheters are another peripheral access option in addition to PIVCs. However, there are currently no established guidelines on their placement.

OBJECTIVES: The aim of this study is to estimate the duration of dwell time for PIVCs, analyze the specific parameters …