Digital Commons Network^™

Research In Library Herald During 2017-2021 : A Bibliometric Analysis, Sangram Haldar

Library Philosophy and Practice (e-journal)

Bibliometric analysis of research papers, articles, etc., has gained increasing importance in Library and Information Science to analyze the publication patterns, authorship patterns, and citation patterns of research papers published within a defined period. Bibliometric analysis is essential for library professionals in the collection development process. This paper intends to analyze the articles published in the journal 'Library Herald' from 2017 to 2021 with the help of different statistical tools and techniques. The results indicate most of the contributions by two authors and one article by six authors and the overall degree of collaboration among authors is 0.62. The study …

Exploring Gender Disparities In The Utilization Of Electronic Information Sources Among Indian Doctoral Students: A Thematic Analysis, Jaswinder Pal Singh Mr., Baljinder Kaur Dr.

Library Philosophy and Practice (e-journal)

Electronic information sources are essential for PhD students in India's expanding higher education system. This cohort's gender differences in electronic information resource access, use, and choice are examined. Inclusion and diversity in digital academia need understanding how gender affects information-seeking and resource utilization. Academic equity policies are informed by qualitative thematic analysis of gender inequality. In the digital age, higher education gender equality is crucial. This study examines Indian PhD students' electronic information use by gender. Gender-related information-seeking habits and preferences are examined to find impediments and opportunities for equal access and use. Scholarship must address gender-related information access and …

Postgraduate Students’ Use Of Electronic Resources For Research Output In Federal University Libraries In The Southeast, Nigeria: Challenges And Strategies For Interventions., Loveth Ogoegbunam Ekwueme, Augustina Chinyere Chime

Library Philosophy and Practice (e-journal)

This study is an empirical study that examined the challenges facing postgraduate students’ use of Electronic Information Resources [EIRs] for research output in federal university libraries in the southeast, Nigeria. It employed a descriptive survey design. The population of the study was registered postgraduate students in five universities libraries in 2017/2018 academic year comprising of 1,522 users. Yaro Yamane formula was used in calculating the sample size for each stratum in order to have proportional representation. A sample size of 421 postgraduate students was selected and used for the study. Instrument for data collection was questionnaire constructed on a four-point …

A Descriptive Analysis Of Ai Guides In Academic Libraries, Nestor Osorio

Library Philosophy and Practice (e-journal)

The purpose of this work is to do an exploratory descriptive analysis of topics included in Artificial Intelligence (AI) electronic library guides of academic libraries. AI library guides from members of the Association of Research Libraries (ARL) are chosen for selection. Of the 48 libraries randomly selected, 25 have AI guides. Data collected was subject to a content analysis process which included the use of terms co-occurrence using the VOSviewer software. The results show three clusters of terms, which are complemented with the discussion of materials found in the guides.

Preservation Of Library Materials In Selected Public Colleges Of Education In Ghana: Strategies And Challenges, Hafiz Abubakari, Dawuda Issah, . Yakubu Baba, Abdul-Majeed Bawa Wumbie

Library Philosophy and Practice (e-journal)

This study investigated the preservation practices selected teacher colleges of education libraries in Ghana. The study examined the existence of preservation policies in the teacher college libraries, preservation techniques in place, level of training given to library staff on preservation and barriers to effective preservation of information resources in the teacher college libraries. The study adopted a survey research design and the instruments used were structured questionnaire administered to forty-four (44) library personnel in six teacher colleges of education in Ghana. The population of the study consisted of para-professional and professional librarians. Descriptive statistics methods were used to analyse the …

E-Learning Advancement In Universities: Expectations Of Lis Students In Bangladesh, Wares-Ul Matin, Khairun Nesa Poly, Md. Samin Yasar

Library Philosophy and Practice (e-journal)

The study explores the ICT usage and computer skills of Library and Information Science (LIS) students in the context of the COVID-19 pandemic. The main objective of the study is to assess the potentials and challenges faced by LIS students in e-learning. The researchers used survey method with a structured questionnaire, involving 209 participants from two leading public universities (University of Dhaka (DU) and Noakhali Science and Technology University (NSTU) in Bangladesh. The collected data underwent rigorous quantitative analysis. Results showed that the majority of LIS students had been using computers for one to three years, with most possessing intermediate …

Robots And Reference Services, Abdullahi Olayinka Isiaka, Biliamin Abiola Aremu, Abdulfatai Soliu, Fahisat Romoke Isiaq

Library Philosophy and Practice (e-journal)

Abstract

This paper explores the integration of robots into reference services in various library and information settings. The use of robots in these contexts has gained momentum in recent years, offering innovative solutions to enhance user experiences, improve access to information, and expand the capabilities of reference librarians. This paper reviews the current state of robots in reference services, discusses their potential benefits and challenges, and examines case studies to illustrate their practical applications. Furthermore, it offers insights into the future prospects and ethical considerations associated with the integration of robots in this domain. This paper delves into the fascinating …

Where Do Community College Students Go For Their Reference Management Needs: Findings From A Survey Study, Ajatshatru Pathak, Sarah Johnson

Library Philosophy and Practice (e-journal)

This research article reports the findings of a survey that was conducted at two community colleges affiliated with a large public university system in the Northeast of the United States. A survey was to explore community college students’ citation management help- seeking habits. Findings suggest that respondents were more likely to utilize Purdue University’s Online Writing Lab (OWL) website for reference management help than other resources. The results also show the impact of various factors (i.e., institution, academic level, undergraduate class level, field of study, age, gender, race/ethnicity, and user type) on students’ citation help -seeking practices. Significant statistical associations …

Characterization Of Cerebrospinal Fluid (Csf) Microbiota At The Time Of Initial Surgical Intervention For Children With Hydrocephalus, Shailly Pandey, Kathryn B. Whitlock, Matthew R. Test, Paul Hodor, Christopher E. Pope, David D. Limbrick, Patrick J. Mcdonald, Jason S. Hauptman, Lucas R. Hoffman, Tamara D. Simon, Cerebrospinal Fluid Microbiota In Shunts (Climb) Study Group

2020-Current year OA Pubs

OBJECTIVE: To characterize the microbiota of the cerebrospinal fluid (CSF) from children with hydrocephalus at the time of initial surgical intervention.

STUDY DESIGN: CSF was obtained at initial surgical intervention. One aliquot was stored in skim milk-tryptone-glucose-glycerol (STGG) medium and the second was unprocessed; both were then stored at -70°C. Bacterial growth for CSF samples stored in STGG were subsequently characterized using aerobic and anaerobic culture on blood agar and MALDI-TOF sequencing. All unprocessed CSF samples underwent 16S quantitative polymerase chain reaction (qPCR) sequencing, and a subset underwent standard clinical microbiological culture. CSF with culture growth (either after storage in …

Assessing An Online Patient Decision Aid About Upper Extremity Reconstructive Surgery For Cervical Spinal Cord Injury: Pilot Testing Knowledge, Decisional Conflict, And Acceptability, William Moritz, Amanda M Westman, Mary C Politi, Dod Working Group, Ida K Fox

2020-Current year OA Pubs

UNLABELLED:

HIGHLIGHTS: People with cervical spinal cord injury prioritize gaining upper extremity function after injury, but few individuals receive information about treatment options.A newly created patient decision aid (PtDA) provides information about recovery after spinal cord injury and the role of traditional tendon and newer nerve transfer surgery to improve upper extremity upper extremity function.The PtDA improved knowledge and decreased decisional conflict in this pilot study.Future work should focus on studying dissemination and implementation of the ptDA into clinical practice.

Designing Home-Based Physical Activity Programs For Rural Cancer Survivors: A Survey Of Technology Access And Preferences, Elizabeth A Salerno, Rohana Gao, Jason Fanning, Neha P Gothe, Lindsay L Peterson, Allison B Anbari, Maura M Kepper, Jingqin Luo, Aimee S James, Edward Mcauley, Graham A Colditz

2020-Current year OA Pubs

BACKGROUND: While technology advances have increased the popularity of remote interventions in underserved and rural cancer communities, less is understood about technology access and preferences for home-based physical activity programs in this cancer survivor population.

PURPOSE: To determine access, preferences, and needs, for a home-based physical activity program in rural cancer survivors.

METHODS: A Qualtrics Research Panel was recruited to survey adults with cancer across the United States. Participants self-reported demographics, cancer characteristics, technology access and usage, and preferences for a home-based physical activity program. The Godin Leisure Time Exercise Questionnaire (GLTEQ) assessed current levels of physical activity. Descriptive statistics …

Updates In The Chronic Kidney Disease-Mineral Bone Disorder Show The Role Of Osteocytic Proteins, A Potential Mechanism Of The Bone-Vascular Paradox, A Therapeutic Target, And A Biomarker, Matthew J Williams, Sarah C White, Zachary Joseph, Keith A Hruska

2020-Current year OA Pubs

The chronic kidney disease-mineral bone disorder (CKD-MBD) is a complex multi-component syndrome occurring during kidney disease and its progression. Here, we update progress in the components of the syndrome, and synthesize recent investigations, which suggest a potential mechanism of the bone-vascular paradox. The discovery that calcified arteries in chronic kidney disease inhibit bone remodeling lead to the identification of factors produced by the vasculature that inhibit the skeleton, thus providing a potential explanation for the bone-vascular paradox. Among the factors produced by calcifying arteries, sclerostin secretion is especially enlightening. Sclerostin is a potent inhibitor of bone remodeling and an osteocyte …

Necrotic Cardiac Myocytes Skew Macrophage Polarization Towards A Classically Activated Phenotype, Wenlong Jiang, Luigi Adamo, Kenji Lim, Scot J Matkovich, Sarah Evans, Cibele Rocha-Resende, Douglas L. Mann

2020-Current year OA Pubs

Necrotic and dying cells release damage-associated molecular patterns (DAMPs) that can initiate sterile inflammatory responses in the heart. Although macrophages are essential for myocardial repair and regeneration, the effect of DAMPs on macrophage activation remains unclear. To address this gap in knowledge we studied the effect of necrotic cardiac myocyte extracts on primary peritoneal macrophage (PPM) cultures in vitro. We first performed unbiased transcriptomic profiling with RNA-sequencing of PPMs cultured for up to 72 hours in the presence and absence of: 1) necrotic cell extracts (NCEs) from necrotic cardiac myocytes in order to mimic the release of DAMPs; 2) lipopolysaccharide …

Prevalence Of Diarrheagenic Escherichia Coli And Impact On Child Health In Cap-Haitien, Haiti, Jenna N. Diaz, Lora L. Iannotti, Sherlie Jean Louis Dulience, Sydney Vie, Xuntian Jiang, Vadim Grigura, Jacques Boncy, Francesca J. Marhone Pierre, F. Matthew Kuhlmann

2020-Current year OA Pubs

BACKGROUND: Diarrheagenic Escherichia coli (DEC) are common pathogens infecting children during their growth and development. Determining the epidemiology and the impact of DEC on child anthropometric measures informs prioritization of prevention efforts. These relationships were evaluated in a novel setting, Cap-Haitien, Haiti.

METHODS: We performed pre-specified secondary analysis of a case-control study of community-dwelling children, 6-36 months of age, enrolled 96 cases with diarrhea and 99 asymptomatic controls. Assessments were performed at enrollment and one month later at follow-up. Established endpoint PCR methodologies targeted DEC gDNA isolated from fecal swabs. The association between DEC and anthropometric z-scores at enrollment was …

#Orthotwitter: Relationship Between Author Twitter Utilization And Academic Impact In Orthopaedic Surgery, Ryan T Halvorson, Sachin Allahabadi, Nicolas Cevallos, Aidan J. Foley, Kelsey Collins, Abel Torres Espin, Brian T. Feeley, Nirav K. Pandya, Jeannie F. Bailey

2020-Current year OA Pubs

Background #OrthoTwitter has evolved to disseminate findings and engage the public. However, the academic impact of Twitter utilization in orthopaedic surgery is unknown. Questions/purposes The purpose of the study was to evaluate relationships between the author and manuscript Twitter activity and citations. Methods Manuscripts in 17 orthopaedic journals from 2018 were identified. Citations, online mentions, impact factors, and subspecialties were obtained. H-index and Twitter account details for authors were obtained for a subset of manuscripts. Relationships between Twitter activity and citations were evaluated. Results 2,473/4,224 (58.5%) manuscripts were mentioned on Twitter (n=29,958 mentions), with Twitter manuscripts cited more frequently (median …

Barriers To And Solutions For Representative Inclusion Across The Lifespan And In Life Course Research: The Need For Structural Competency Highlighted By The Covid-19 Pandemic, Madison N Lecroy, Ebony B Carter, Sarah S Farabi, Dominic N Reeds, Et Al.

2020-Current year OA Pubs

Exclusion of special populations (older adults; pregnant women, children, and adolescents; individuals of lower socioeconomic status and/or who live in rural communities; people from racial and ethnic minority groups; individuals from sexual or gender minority groups; and individuals with disabilities) in research is a pervasive problem, despite efforts and policy changes by the National Institutes of Health and other organizations. These populations are adversely impacted by social determinants of health (SDOH) that reduce access and ability to participate in biomedical research. In March 2020, the Northwestern University Clinical and Translational Sciences Institute hosted the "Lifespan and Life Course Research: integrating …

A Randomized Implementation Trial To Increase Adoption Of Evidence-Informed Consent Practices, Erin D Solomon, Jessica Mozersky, Melody Goodman, Meredith V Parsons, Kari A Baldwin, Annie B Friedrich, Jenine K Harris, James M Dubois

2020-Current year OA Pubs

INTRODUCTION: Several evidence-informed consent practices (ECPs) have been shown to improve informed consent in clinical trials but are not routinely used. These include optimizing consent formatting, using plain language, using validated instruments to assess understanding, and involving legally authorized representatives when appropriate. We hypothesized that participants receiving an implementation science toolkit and a social media push would have increased adoption of ECPs and other outcomes.

METHODS: We conducted a 1-year trial with clinical research professionals in the USA (

RESULTS: Participants who engaged more with the toolkit were more likely to have tried to implement an ECP during the trial …

Aromatic Amino Acid Metabolites Alter Interferon Signaling And Influenza Pathogenesis, Gautam Anand, Colin Clark-Dinovo, Alexandra M Perry, Victoria M Goodwin, Emma St Raymond, Sonia Sakleshpur, Ashley L Steed

2020-Current year OA Pubs

The ability of gut microbial metabolites to influence the host is increasingly recognized. The microbiota extensively metabolizes the three aromatic amino acids, tryptophan, tyrosine, and phenylalanine. Previously we have found that a metabolite of tyrosine, 4-OH-phenylpropionic acid, can enhance type I interferon (IFN) signaling and protect from influenza pathogenesis in a murine model. Herein we screened 17 related aromatic amino acid metabolites for effects on IFN signaling in human lung epithelial cells and monocytes alone and in the presence of IFN-β, influenza, and LPS. While the tryptophan family metabolites reduced IFN signaling in both cell types, the tyrosine and phenylalanine …

Risk And Protection Of Different Rare Protein-Coding Variants Of Complement Component C4a In Age-Related Macular Degeneration, Johanna M Seddon, Dikha De, William Casazza, Shun-Yun Cheng, Claudio Punzo, Mark Daly, Danlei Zhou, Samantha L Coss, John P Atkinson, Chack-Yung Yu

2020-Current year OA Pubs

No abstract provided.

Understanding Tailoring To Support The Implementation Of Evidence-Based Interventions In Healthcare: The Customise Research Programme Protocol, Sheena M Mchugh, Fiona Riordan, Claire Kerins, Geoff Curran, Cara C Lewis, Justin Presseau, Luke Wolfenden, Byron J Powell

2020-Current year OA Pubs

Although there are effective evidence-based interventions (EBIs) to prevent, treat and coordinate care for chronic conditions they may not be adopted widely and when adopted, implementation challenges can limit their impact. Implementation strategies are "methods or techniques used to enhance the adoption, implementation, and sustainment of a clinical program or practice". There is some evidence to suggest that to be more effective, strategies should be

Expression Of Non-Phosphorylatable S5a-L-Plastin Exerts Phenotypes Distinct From L-Plastin Deficiency During Podosome Formation And Phagocytosis, Xue Lin, Praveen Krishnamoorthy, Emma C Walker, Hemant Joshi, Sharon Celeste Morley

2020-Current year OA Pubs

No abstract provided.

Treg-Specific Deletion Of The Phosphatase Shp-1 Impairs Control Of Inflammation In Vivo, Qinlei Gu, Kenneth S Tung, Ulrike M Lorenz

2020-Current year OA Pubs

INTRODUCTION: To achieve a healthy and functional immune system, a delicate balance exists between the activation of conventional T cells (Tcon cells) and the suppression by regulatory T cells (Treg). The tyrosine phosphatase SHP-1, a negative regulator of TCR signaling, shapes this 'activation-suppression' balance by modulating Tcon cell resistance to Treg-mediated suppression. Treg cells also express SHP-1, but its role in influencing Treg function is still not fully understood.

METHODS: We generated a Treg-specific SHP-1 deletion model,

RESULTS: We show that SHP-1 modulates Treg suppressive function at different levels. First, at the intracellular signaling level in Treg cells, SHP-1 attenuates …

Targeted Aso-Mediated Atp1a2 Knockdown In Astrocytes Reduces Sod1 Aggregation And Accelerates Disease Onset In Mutant Sod1 Mice, Abhirami K. Iyer, Kathleen M. Schoch, Anthony Verbeck, Grant Galasso, Hao Chen, Sarah Smith, Anna Oldenborg, Timothy M. Miller, Celeste M. Karch, Azad Bonni

2020-Current year OA Pubs

Astrocyte-specific ion pump α2-Na+/K+-ATPase plays a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Here, we test the effect of Atp1a2 mRNA-specific antisense oligonucleotides (ASOs) to induce α2-Na+/K+-ATPase knockdown in the widely used ALS animal model, SOD1*G93A mice. Two ASOs led to efficient Atp1a2 knockdown and significantly reduced SOD1 aggregation in vivo. Although Atp1a2 ASO-treated mice displayed no off-target or systemic toxicity, the ASO-treated mice exhibited an accelerated disease onset and shorter lifespan than control mice. Transcriptomics studies reveal downregulation of genes involved in oxidative response, metabolic pathways, trans-synaptic signaling, and upregulation of genes involved in glutamate receptor …

Rev-Erb Activation As A Novel Pharmacological Approach For Treating Inflammatory Pain, Sangeet Makhija, Joshua D Griffett, Giri Babu Veerakanellore, Thomas P Burris, Bahaa Elgendy, Kristine Griffett

2020-Current year OA Pubs

Pain is a complex problem affecting millions of people worldwide. The current therapies to reduce pain are limited as many treatment options inadequately address the causes of pain, lead to tolerance of the drug, or have adverse effects including abuse potential. While there are many causes of pain, one underlying mechanism to the pathogenesis and maintenance of pain conditions is chronic inflammation driven by the NLRP3 inflammasome. Several inflammasome inhibitors are currently under investigation however have the potential to suppress the functioning of the innate immune system, which may cause unwanted affects in patients. Here, we show that the nuclear …

Cell Wall Composition In Cryptococcus Neoformans Is Media Dependent And Alters Host Response, Inducing Protective Immunity, Rajendra Upadhya, Woei C Lam, Camaron R Hole, Joseph G Vasselli, Jennifer K Lodge

2020-Current year OA Pubs

INTRODUCTION:

OBJECTIVE: The purpose of this study was to determine how different media influenced the amount of chitin and chitosan in the cell wall, which in turn impacted the cell wall architecture and host response.

METHODS: Yeast extract, peptone, and dextrose (YPD) and yeast nitrogen base (YNB) are two commonly used media for growing Cryptococcus before use in in vitro or in vivo experiments. As a result,

RESULTS: We observed that the growth of wild-type

CONCLUSION: These findings emphasize the importance of culture media and pH during growth in shaping the content and organization of the

Toward A Computational Theory Of Manifold Untangling: From Global Embedding To Local Flattening, Xin Li, Shuo Wang

2020-Current year OA Pubs

It has been hypothesized that the ventral stream processing for object recognition is based on a mechanism called cortically local subspace untangling. A mathematical abstraction of object recognition by the visual cortex is how to untangle the manifolds associated with different object categories. Such a manifold untangling problem is closely related to the celebrated kernel trick in metric space. In this paper, we conjecture that there is a more general solution to manifold untangling in the topological space without artificially defining any distance metric. Geometrically, we can either

Conditional Protein Degradation In Yarrowia Lipolytica Using The Auxin-Inducible Degron, Zhenlin Han, Jessica Maruwan, Yinjie Tang, Wei Wen Su

2020-Current year OA Pubs

Conditional protein degradation is a powerful tool for controlled protein knockdown. The auxin-inducible degron (AID) technology uses a plant auxin to induce depletion of degron-tagged proteins, and it has been shown to be functional in several non-plant eukaryotes. In this study, we demonstrated AID-based protein knockdown in an industrially important oleaginous yeast

Adapting A Mobile App To Support Patients With Anorexia Nervosa Following Post-Acute Care: Perspectives From Eating Disorder Treatment Center Stakeholders, Anneliese Haas, Agatha A Laboe, Claire G Mcginnis, Marie-Laure Firebaugh, Jillian Shah, Anna M Bardone-Cone, Kathleen M Pike, C Barr Taylor, Denise E Wilfley, Ellen E Fitzsimmons-Craft

2020-Current year OA Pubs

INTRODUCTION: Anorexia nervosa (AN) is a harmful, life-threatening illness. Patients with severe AN often receive acute treatment but, upon discharge, experience high relapse rates. Evidence-based, outpatient treatment following acute care is critical to preventing relapse; however, numerous barriers (e.g., location, financial limitations, low availability of providers) preclude individuals from accessing treatment. mHealth technologies may help to address these barriers, but research on such digital approaches for those with AN is limited. Further, such technologies should be developed with all relevant stakeholder input considered from the outset. As such, the present study aimed to garner feedback from eating disorder (ED) treatment …

Ehealth Technology In Cardiac Exercise Therapeutics For Pediatric Patients With Congenital And Acquired Heart Conditions: A Summary Of Evidence And Future Directions, David A White, Aimee M Layton, Tracy Curran, Naomi Gauthier, William B Orr, Kendra Ward, Meg Vernon, Matthew N Martinez, Malloree C Rice, Katherine Hansen, Megan Prusi, Jesse E Hansen

2020-Current year OA Pubs

Many children and adolescents with congenital and acquired heart disease (CHD) are physically inactive and participate in an insufficient amount of moderate-to-vigorous intensity exercise. Although physical activity (PA) and exercise interventions are effective at improving short- and long-term physiological and psychosocial outcomes in youth with CHD, several barriers including resource limitations, financial costs, and knowledge inhibit widespread implementation and dissemination of these beneficial programs. New and developing eHealth, mHealth, and remote monitoring technologies offer a potentially transformative and cost-effective solution to increase access to PA and exercise programs for youth with CHD, yet little has been written on this topic. …

A Novel Dual Nlrp1 And Nlrp3 Inflammasome Inhibitor For The Treatment Of Inflammatory Diseases, Callum Ah Docherty, Anuruddika J Fernando, Sarah Rosli, Maggie Lam, Roland E Dolle, Manuel A Navia, Ronald Farquhar, Danny La France, Michelle D Tate, Christopher K Murphy, Adriano G Rossi, Ashley Mansell

2020-Current year OA Pubs

OBJECTIVES: Inflammasomes induce maturation of the inflammatory cytokines IL-1β and IL-18, whose activity is associated with the pathophysiology of a wide range of infectious and inflammatory diseases. As validated therapeutic targets for the treatment of acute and chronic inflammatory diseases, there has been intense interest in developing small-molecule inhibitors to target inflammasome activity and reduce disease-associated inflammatory burden.

METHODS: We examined the therapeutic potential of a novel small-molecule inhibitor, and associated derivatives, termed ADS032 to target and reduce inflammasome-mediated inflammation

RESULTS: We describe ADS032 as the first dual NLRP1 and NLRP3 inhibitor. ADS032 is a rapid, reversible and stable inflammasome …