Digital Commons Network^™

Toward More Rigorous And Informative Nutritional Epidemiology: The Rational Space Between Dismissal And Defense Of The Status Quo, Andrew W Brown, Stella Aslibekyan, Dennis Bier, Rafael Ferreira Da Silva, Adam Hoover, David M Klurfeld, Eric Loken, Evan Mayo-Wilson, Nir Menachemi, Greg Pavela, Patrick D Quinn, Dale Schoeller, Carmen Tekwe, Danny Valdez, Colby J Vorland, Leah D Whigham, David B Allison

Faculty, Staff and Students Publications

To date, nutritional epidemiology has relied heavily on relatively weak methods including simple observational designs and substandard measurements. Despite low internal validity and other sources of bias, claims of causality are made commonly in this literature. Nutritional epidemiology investigations can be improved through greater scientific rigor and adherence to scientific reporting commensurate with research methods used. Some commentators advocate jettisoning nutritional epidemiology entirely, perhaps believing improvements are impossible. Still others support only normative refinements. But neither abolition nor minor tweaks are appropriate. Nutritional epidemiology, in its present state, offers utility, yet also needs marked, reformational renovation. Changing the status quo …

The ‘Homework Gap’ And Academic Achievement In High School Science: An Ecological Perspective For Policymakers And Practitioners, Tianca Crocker, David Kleitsch

National Youth Advocacy & Resilience Journal

Information and communication technologies (ICTs) are increasingly required within K-12 educational settings, yet the impact of youth’s access to and use of digital resources outside of the classroom on academic achievement is only beginning to be explored in the literature. This study used data from the Fragile Families & Child Wellbeing Study to assess the relationship between grades in high school science and digital equity across the learner’s ecological environment. Digital inequities experienced by school-aged youth are referred to as the homework gap. The COVID-19 pandemic placed new urgency on resolving the homework gap as millions of students shifted to …

A “Post” Pandemic(S) Village Check-In: Pulse Checks And Recommendations For A Hard Re-Set In Education, Jarvais J. Jackson, Alesia Mickle Moldavan, Anne Valauri

National Youth Advocacy & Resilience Journal

Utilizing the lens of the “pandemic as portal” (Roy, 2020; Souto-Manning, 2021) and the need for a “hard re-set” (Ladson-Billings, 2021) of our current education system, this literature synthesis engages with head, health, and home to consider what a new normal could look like as we take a “village check-in” of each area. For head, we consider the systemic barriers to equitable academic achievement that have long been in place for Black and Brown students. When considering health, we look at the impact of the pandemic on teacher well-being and how this may impact their ability to teach effectively and …

Toward Modernization: Using Strategic Development To Address Deficits In The Juvenile Justice System, David A. Mcleod, Emily A. Roberts

National Youth Advocacy & Resilience Journal

The Juvenile Justice System was established on the premise of rehabilitative action for behaviors that have led youth to the criminal justice system. However, the system has increasingly moved away from this original concept toward a punitive model. The authors present how this movement resulted in the devolution of human rights for the youth involved, a decrease in public safety, and a radical departure from fiscal responsibility related to the theoretical origins of rehabilitation. Studies on topics ranging from costs of correctional centers to trauma experienced by youth in these systems, along with many others, are compared to identify specific …

Parent Education: A Key Aspect In Prevention And Intervention Of Bullying In School Communities, Kanessa M. Doss, Sherrionda H. Crawford

National Youth Advocacy & Resilience Journal

Bullying continues to be an omnipresent public health issue in school communities, affecting children’s and adolescent’s academic success, socio-emotional well-being, and overall development. Schools play a fundamental role in addressing bullying, yet parent and community involvement is equally critical. This article explores the significance of parent education in bullying prevention and intervention within school communities. The role of schools and community stakeholders with implications for each group are discussed. Resources are provided to share with parents/caregivers and facilitate their involvement in anti-bullying initiatives within school communities. The authors offer recommendations for school communities to promote anti-bullying awareness, facilitate parent education …

Exploring Adolescent Resilience During Covid-19 In A South African Township Context, Shannon Enid Wakefield Ms, Linda Theron Prof

National Youth Advocacy & Resilience Journal

Abstract

COVID-19 has permeated news since December 2019 and has impacted all areas of life. Despite widespread coverage of COVID-related risks, there is limited understanding of adolescent resilience in Global South contexts (e.g., Africa) and against the backdrop of COVID-19. We, therefore, conducted a qualitative secondary analysis of 79 documents (i.e., drawings and written explanations) generated by school-attending adolescents in grades eight to ten in Zamdela, South Africa, during 2020 lockdown. Using a multisystemic resilience approach, we explored what these documents revealed as resilience enabling for adolescents in a township context during COVID-19. The thematic findings highlight the importance of …

Clinical Trial Design Challenges And Opportunities For Emerging Treatments For Opioid Use Disorder: A Review, Brian D Kiluk, Bethea A Kleykamp, Sandra D Comer, Roland R Griffiths, Andrew S Huhn, Matthew W Johnson, Kyle M Kampman, Marco Pravetoni, Kenzie L Preston, Ryan Vandrey, Cecilia L Bergeria, Michael P Bogenschutz, Randall T Brown, Kelly E Dunn, Robert H Dworkin, Patrick H Finan, Peter S Hendricks, Elisabeth J Houtsmuller, Thomas R Kosten, Dustin C Lee, Frances R Levin, Aimee Mcrae-Clark, Charles L Raison, Kurt Rasmussen, Dennis C Turk, Roger D Weiss, Eric C Strain

Faculty, Staff and Students Publications

Importance: Novel treatments for opioid use disorder (OUD) are needed to address both the ongoing opioid epidemic and long-standing barriers to existing OUD treatments that target the endogenous μ-opioid receptor (MOR) system. The goal of this review is to highlight unique clinical trial design considerations for the study of emerging treatments for OUD that address targets beyond the MOR system. In November 2019, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the US Food and Drug Administration sponsored a meeting to discuss the current evidence regarding potential treatments for OUD, including cannabinoids, …

The Effect Of Multi-Material Architecture On The Ex Vivo Osteochondral Integration Of Bioprinted Constructs, Matthew L Bedell, Ziwen Wang, Katie J Hogan, Angelica L Torres, Hannah A Pearce, Letitia K Chim, K Jane Grande-Allen, Antonios G Mikos

Faculty, Staff and Students Publications

Extrusion bioprinted constructs for osteochondral tissue engineering were fabricated to study the effect of multi-material architecture on encapsulated human mesenchymal stem cells’ tissue-specific matrix deposition and integration into an ex vivo porcine osteochondral explant model. Two extrusion fiber architecture groups with differing transition regions and degrees of bone- and cartilage-like bioink mixing were employed. The gradient fiber (G-Fib) architecture group showed an increase in chondral integration over time, 18.5 ± 0.7 kPa on Day 21 compared to 9.6 ± 1.6 kPa on Day 1 for the required peak push-out force, and the segmented fiber (S-Fib) architecture group did not, which …

Dantrolene Inhibits Lysophosphatidylcholine-Induced Valve Interstitial Cell Calcific Nodule Formation Via Blockade Of The Ryanodine Receptor, Christopher B Sylvester, Farshad Amirkhosravi, Angelina S Bortoletto, William J West, Jennifer P Connell, K Jane Grande-Allen

Faculty, Staff and Students Publications

Calcific aortic valve disease (CAVD), a fibrocalcific thickening of the aortic valve leaflets causing obstruction of the left ventricular outflow tract, affects nearly 10 million people worldwide. For those who reach end-stage CAVD, the only treatment is highly invasive valve replacement. The development of pharmaceutical treatments that can slow or reverse the progression in those affected by CAVD would greatly advance the treatment of this disease. The principal cell type responsible for the fibrocalcific thickening of the valve leaflets in CAVD is valvular interstitial cells (VICs). The cellular processes mediating this calcification are complex, but calcium second messenger signaling, regulated …

Protocol Of Detection Of West Nile Virus In Clinical Samples, Hephzibah Nwanosike, Freedom M Green, Kristy O Murray, Jill E Weatherhead, Shannon E Ronca

Faculty, Staff and Students Publications

West Nile virus (WNV) is one of the leading causes of arboviral encephalitis in the United States but is often underdiagnosed. Despite the wide breadth of WNV-induced clinical disease syndromes, many of the symptoms associated with WNV are nonspecific at the time of presentation; thus, choosing the right diagnostic tool is essential to not only understand the true burden of disease but also provide pathogen-directed interventions for WNV-infected patients. In this chapter, we briefly discuss the three most common types of diagnostic methods for WNV in human clinical samples: nucleic acid detection, enzyme-linked immunoassay (ELISA), and plaque reduction neutralization test …

Improving Communication Between The Emergency Department And Prehospital Emergency Medical Services Through The Use Of A Secure Messaging Application: A Quality Improvement Project, Jacob G. Petlon

Master's Theses and Capstones

Background: Communication between emergency medical services (EMS) and the emergency department (ED) is a key part of treating patients being transported by ambulance. This communication is moving away from traditional radio and cell phone calls to the use of secure text-based apps. These apps can generate metrics and provide real time location information that is not available using traditional methods. Increased use of these apps can improve communication between EMS and receiving EDs.

Local Problem: Wildcat hospital introduced the EMS communication app Twiage in May of 2023. There is low utilization of the app and some EMS and ED …

Establishing A Protocol To Address Workplace Violence And Increase The Perceptions Of Safety Among Emergency Department Nurses: A Quality Improvement Initiative, Devan M. Robidoux

Master's Theses and Capstones

Background: Violence against emergency department nurses has become a widespread phenomenon that can greatly impact a nurse's job satisfaction and performance. Research has been scarce in examining the relationship between workplace violence and its underlying consequences. There remains a disconnect between precursors of violence against nurses perpetrated by patients and the cultural expectation that violence is a part of the nurses job and, subsequently, what they signed up for when going into the field. Nurses learn that having a greater understanding of the value in the lived experience of their patients leads to better quality delivery of care. However, culturally …

Reducing Violence In The Workplace: A Quality Improvement Project, Molly Mcqueeney

Master's Theses and Capstones

Abstract

BACKGROUND: Violence in the United States has significant impacts on the healthcare system. On average, there are about 7.8 per 1,000 workers yearly that experience violent injuries (Grossman & Choucair, 2019). In 2016, it was estimated that approximately $429 million was added to treat and prevent injuries to healthcare workers (Grossman & Choucair, 2019). By implementing the Broset Violence Checklist (BVC) as a screening tool for early identification of risk for violence, there is a possibility for a reduction in the number of violent occurrences in the workplace.

LOCAL PROBLEM: Within the given microsystem, there is a lack of …

Registered Nurse Competencies And The Implementation Of Self-Care Interventions Among Surgical Patients With Type Two Diabetes: A Quality Improvement Project, Elizabeth Fossum

Master's Theses and Capstones

Background: Type 2 Diabetes is a chronic disease that requires a holistic approach, an in-depth understanding of self-care, education comprehension, and an effective relationship between healthcare professionals and the individual patient (Saeed et al., 2018). Due to a variety of factors such as increased nurse-to-patient ratios, inconsistent education methods, and limited confidence levels among registered nurses, important treatment measures and discussion of one’s T2DM diagnoses are often not addressed. Initiatives to improve education methods and nursing confidence levels will create more effective treatment measures and discharge education. Local Problem: Registered nurses spend minimal time educating patients on the severity of …

Religion, Spirituality, And Coping During The Pandemic: Perspectives Of Dementia Caregivers, Katherine Carroll Britt, Kathy C Richards, Kavita Radhakrishnan, Andrea Vanags-Louredo, Eunice Park, Nalaka S Gooneratne, Liam Fry

Faculty, Staff and Students Publications

Religious and spiritual (R/S) practices support individuals during difficult situations. The COVID-19 social distancing restrictions may have limited access to R/S practices for older adults with Alzheimer’s disease related dementia (ADRD) and their caregivers, affecting coping and well-being. This qualitative study explored the impact of social distancing on R/S practices and coping in ADRD-caregiver dyads from the perspective of caregivers. Interviews were conducted with 11 family caregivers of older adults with ADRD residing in nursing homes (n = 4) or private homes (n = 7). Caregivers continued individual and started virtual R/S practices which improved their ability to …

Soft X-Ray And Susceptibility Based Magnetic Resonance Imaging To Map Iron Distribution In Apples: Initial Results To Model Iron Storage In Water-Deficient Or Dehydrated Biological Tissue, Subhendra N. Sarkar, Eric Lobel, Evans Lespinasse, Zoya Vinokur, Analia Basilicata, Sonia Orellana, Maria Orellana, Aaliyah Salmon, Joanna Syska, Aravis Mcbroom, Jian Wang, Anam Riaz, Jodi-Ann Douglas

Publications and Research

Radiology departments have contributed significantly to greenhouse gases including release of toxic imaging contrast media to environment. We feel Radiology also has several spectroscopy and imaging tools that may apply to monitor and support cleaner environmental goals. The current manuscript is one of the firsts to prompt Radiology to move in that direction by non invasive imaging of bio metals that are less abundant in biological tissues but play key roles as co-factors in tissue structure and function. Conventional analytical tools are mostly invasive and cannot characterize the native oxidation states of bio metals. We chose carbohydrate matrix of metal-rich …

Mapping For Impact: Actionable Spatial Literacy Through Counter-Mapping, Rachel Hansen

Dissertations and Theses @ UNI

Counter-mapping is a technique that young people can use to take informed action on community issues through the mapping process. This mixed-methods study examined how ninth-graders in a large urban district in Iowa developed spatial thinking skills while engaging in counter-mapping in their community and the extent to which they used those maps to take informed action. A nine-week learning progression for counter-mapping scaffolded progress variables across three different spatial thinking standards and one inquiry standard. Findings indicated that students improved throughout the learning progression, but some needed teacher support to conduct spatial inquiries. Chances of reaching the upper anchor …

Do The Culturable Microbial Groups Present In Cutaway Bogs Change According To Temporal Variation? Pilot Study Based On The Midlands In The Republic Of Ireland, Gouri Nilakshika Atapattu, Tara Battersby, Michelle Giltrap, Furong Tian

Articles

Cutaway peatlands in the midlands of the Republic of Ireland are rarely the focus of scientific studies. The soil quality and related microenvironment have been severely impacted by peat extraction. Returning them to a ‘near-natural state' would require greater insights into this ecological niche. The current research took the initiative to study the microbiology of vast cutaway sites in the midlands of Ireland. Peat was collected over two seasons in January, February and April. Homogenised peat was aseptically cultured on a range of specific and non-specific culture media. Microbial enumeration, Gram staining and other microscopic observations of morphologically distinct microorganisms …

Views Of The Irish Judiciary On Technology In Courts: Results Of A Survey, Brian M. Barry Dr, Rónán Kennedy Dr

Articles

Technology continues to transform how judges perform their functions, both in Ireland and elsewhere. This article reports the results of a survey of Irish judges on their use of technology in their role, their attitudes towards technology, and their views on how it impacts on the judicial function. The survey, part of a global survey, found that Irish judges habitually used digital technologies, and were broadly satisfied with the technology available in chambers, but less so with what was provided in courtrooms. Although generally happy to embrace change, the majority of respondents were concerned with, and did not prefer, online …

Investigating K-12 Computing Education In Four African Countries (Botswana, Kenya, Nigeria, And Uganda), Ethel Tshukudu, Sue Sentance, Oluwatoyin Adelakun-Adeyemo, Keith Quille, Ziling Zhong

Articles

As K-12 computing education becomes more established throughout the world, there is an increasing focus on accessibility for all, whether in a particular country or setting or in areas of the world that may not yet have computing established. This is primarily articulated as an equity issue. The recently developed capacity for, access to, participation in, and experience of computer science education (CAPE) Framework is one way of demonstrating stages and dependencies and understanding relative equity, taking into consideration the disparities between sub-populations. While there is existing research that covers the state of computing education and equity issues, it is …

Nanomaterials-Based Biosensors For The Detection Of Prostate Cancer Biomarkers: Recent Trends And Future Perspective, Baljit Singh, Shiliang Ma, Tony O. Hara, Sargun Singh

Articles

Cancer is among the leading causes of death and an important barrier to improving life expectancy globally. Prostate cancer is the second most common cancer in men worldwide. The detection of biomarkers in body fluids is the key topic for the diagnosis and prognosis of prostate cancer. Despite advances in prostate cancer detection methods, therapeutic agents and new biomarkers, prostate cancer remains a serious challenge. Prostate-specific antigen (PSA) is widely recognized as an important biomarker for the diagnosis of prostate cancer although researchers have also investigated the use of alternative biomarkers. Design and development of novel biosensors for prostate cancer …

Theoretical Background Of Cryptography, Rusul Mansoor Al-Amri, Dalal N. Hamood, Alaa Kadhim Farhan

Mesopotamian Journal of CyberSecurity

Cryptography is the practice of secure communication and the study of secure communication techniques. The theoretical foundations of cryptography include concepts such as cryptography, secure key exchange, digital signatures, and authentication. These technologies are used to protect the confidentiality, integrity, and reliability of information while it is being transmitted over a network or stored in digital form. The core of encryption is the concept of an encryption algorithm, which is a set of mathematical rules used to encrypt and decrypt data. The security of a cryptographic system depends on the strength of the underlying algorithm and the confidentiality of the …

The Impact Of Blockchain Technique On Trustworthy Healthcare Sector, Nour Sadeq, Zeid Hamzeh, Ghalia Nassreddine, Tamima Elhassan, Tamima Elhassan

Mesopotamian Journal of CyberSecurity

Following the COVID epidemic, the healthcare sector faced numerous issues as telehealth became more prevalent and the necessity for a safe and efficient healthcare record system became critical. Many issues plague the healthcare industry today, including security, trust, data availability, and drug traceability. Blockchain technology is a relatively new technology that has demonstrated its effectiveness in a variety of industries, including finance, banking, bitcoin, and healthcare. This research investigates the impact of blockchain on the trustworthiness of healthcare. The authors adopt a descriptive-analytical methodology. The trustworthiness of the healthcare sector is considered a dependent variable. However, blockchain technology is considered …

Electrolyte Synthesis And Engineering For Alkali Metal Batteries, Yiwen Zhang

Dartmouth College Ph.D Dissertations

Batteries have been in increasing demand over the last decade for portable electronic devices, electric vehicles, and grid-scale energy storage systems. While the electrode materials define the characteristic features of a battery system, the composition of the electrolyte is of critical importance and needs to be engineered for different battery systems to ensure superior electrochemical performance. In this thesis, the basic functionality and fundamental mechanism of the electrolytes in battery systems are first introduced. Then, three major electrolyte engineering strategies are demonstrated, including electrolyte composition formulation, electrolyte-electrode component modification, and function-oriented electrolyte design. Firstly, the low-temperature capacity restraint of lithium …

High Throughput Cellular Screening Technologies For Engineering Enhanced-Solubility And Deimmunized Biologics, Andrew Y. Chang

Dartmouth College Ph.D Dissertations

High throughput cell-based screening methodologies have become core development tools for the generation and engineering of various biotherapeutics. For example, SpCas9 variants for use in CRISPR-Cas9 therapeutics have been engineered for enhanced specificity using a high throughput directed evolution approach in E. coli. Additionally, antibodies are routinely discovered and engineered for high affinity binding using yeast surface display. These high throughput techniques typically involve generation of large protein libraries which require innovative screening strategies depending on the target protein’s function. In this thesis work, we describe high throughput protein library screening approaches to address recombinant biologic aggregation and immunogenicity …

Airborne Sound And Substrate-Borne Vibration In Orthopteran Communication, Ciara E. Kernan

Dartmouth College Ph.D Dissertations

The challenge of attracting and locating potential mates has driven the evolution of diverse mate-finding signaling systems. These systems can be complex, with multiple signals or signal components spread across different sensory modalities. When multiple modalities are combined in one communication system, features of each can be important to individual fitness; over evolutionary time, these can shape investment in different parts of a signal repertoire. One group of animals that commonly uses multiple signal modalities is Orthoptera. Cricket and katydid species within this order often produce airborne sound calls to advertise to potential mates. Many also produce substrate-borne vibrational signals. …

Interactomics And Targeted Protein Degradation For Kinase Substrate Discovery, Juan C. Mercado Del Valle

Dartmouth College Ph.D Dissertations

Reversible phosphorylation is one of the most important post translational modifications that has allowed us as a species to quickly adapt to changing molecular environments due to external stimulation. This process is only capable through the activity of kinases to carry out the targeting of specific substrates defined by their recognition motif allowing for selective phosphorylation and activation and inactivation of distinct pathways as well as other changes that permit cell survival. By being so important for the maintenance of the cells disruption often leads to worsening of the cells, leading to various diseases like cancer, immunological and neurodegenerative disorders. …

Judging China: The Chinese Legal System In U.S. Courts, Donald C. Clarke

GW Law Faculty Publications & Other Works

How should American courts understand China’s legal system? How do they understand it, and are they doing a good job? These questions have become important as economic and social ties between China and the United States have mushroomed since China’s days of Maoist isolation. The answers have implications not just for China-related cases, but for the way U.S. courts treat authoritarian and illiberal legal systems more generally.

This Article presents the first attempt to answer these questions empirically through an intensive study of all cases in which parties either sought dismissal to China on forum non conveniens grounds or sought …

We Must Protect Investors And Our Banking System From The Crypto Industry, Arthur E. Wilmarth Jr.

GW Law Faculty Publications & Other Works

The crypto boom and crash of 2020-22 demonstrated that (i) cryptocurrencies with fluctuating values are extremely risky and highly volatile assets, and (ii) cryptocurrencies known as “stablecoins” are vulnerable to systemic runs whenever there are serious doubts about the adequacy of reserves backing those stablecoins. Crypto firms amplified the crypto boom with aggressive and deceptive marketing campaigns that targeted unsophisticated retail investors. Scandalous failures of prominent crypto firms accelerated the crypto crash by inflicting devastating losses on investors and undermining public confidence in crypto-assets.

Federal and state regulators have allowed banks to become significantly involved in crypto-related activities. Several FDIC-insured …

Compensation Under The Microscope: Virginia, Jeffrey Gutman

GW Law Faculty Publications & Other Works

Enacted in 2004, the Virginia wrongful conviction compensation statute is unique in the United States. The decision to award compensation rests not with a court or an administrative agency, but with the state legislature. Unlike other compensation statutes that create an entitlement to compensation when a person is found eligible, the Virginia statute explicitly says that “[t]he payment and receipt of any compensation for wrongful incarceration shall be contingent upon the General Assembly appropriating funds for that purpose. This article shall not 2 provide an entitlement to compensation for persons wrongfully incarcerated or require the General Assembly to appropriate funds …