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2023

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Boundary Lines Crossed? Seeking Honor After The Vietnam War Took Their Sons, Hannah Ackerman Jan 2023

Boundary Lines Crossed? Seeking Honor After The Vietnam War Took Their Sons, Hannah Ackerman

Dissertations and Theses @ UNI

On June 3 1969, a Navy destroyer, USS Frank E. Evans DD-754 and seventy-four Evans sailors who were serving on her were killed in an accident with the Australian aircraft carrier, HMAS Melbourne, in the South China Sea. Family members would later discover their names were not inscribed on the Vietnam Veterans Memorial Wall in Washington, D.C. due to criteria which disqualified them. Facts of the Evans case to determine if the names of 74 Evans sailors rightfully belong on the Wall are examined. Continuing legislative efforts by the Evans Association to put the names on the Wall and other …


The Tmem106b T186s Coding Variant Increases Neurite Arborization And Synaptic Density In Primary Hippocampal Neurons, Quynh Nguyen, Caleb A Wood, Peter J Kim, Joanna L Jankowsky Jan 2023

The Tmem106b T186s Coding Variant Increases Neurite Arborization And Synaptic Density In Primary Hippocampal Neurons, Quynh Nguyen, Caleb A Wood, Peter J Kim, Joanna L Jankowsky

Faculty, Staff and Students Publications

The lysosomal protein TMEM106B was identified as a risk modifier of multiple dementias including frontotemporal dementia and Alzheimer’s disease. The gene comes in two major haplotypes, one associated with disease risk, and by comparison, the other with resilience. Only one coding polymorphism distinguishes the two alleles, a threonine-to-serine substitution at residue 185 (186 in mouse), that is inherited in disequilibrium with multiple non-coding variants. Transcriptional studies suggest synaptic, neuronal, and cognitive preservation in human subjects with the protective haplotype, while murine in vitro studies reveal dramatic effects of TMEM106B deletion on neuronal development. Despite this foundation, the field has not …


Securing Global Health: Global Citizenship And Covid-19 Awareness, Birol Bulut, Muhammed Kursat Oksuzoglu Jan 2023

Securing Global Health: Global Citizenship And Covid-19 Awareness, Birol Bulut, Muhammed Kursat Oksuzoglu

Georgia Educational Researcher

The aim of this study was to investigate the relationship between prospective social studies teachers' global citizenship levels and their COVID-19 awareness levels. To do that, Relational survey model, one of the quantitative research methods, was used. The sample consisted of 409 prospective social studies teachers selected by simple random sampling method from six universities in Turkey. Global Citizenship Scale (GCS), The Coronavirus (COVID-19) Awareness Scale (CAS), and the Personal Information Form developed by the researchers were used in data collection. The t-test, Pearson Correlation Analysis and Multiple Regression Analysis were per-formed to analyze data. A positive and significant relationship …


The Elementary Assistant Principal: Exploring Mentorship As A Development Pathway For The Principal Job Role, Adib Shakir, Chinasa Elue, Sheryl J. Croft, Nicholas Clegorne Jan 2023

The Elementary Assistant Principal: Exploring Mentorship As A Development Pathway For The Principal Job Role, Adib Shakir, Chinasa Elue, Sheryl J. Croft, Nicholas Clegorne

Georgia Educational Researcher

The purpose of this qualitative phenomenographical article was to explore the different ways that elementary assistant principals experienced mentoring from their elementary principals as a way to provide the requisite leadership development that would lead them to become a principal. This research study was conducted using in-depth semi-structured interviews as the primary data source. Ancillary data sources such as demographic surveys, reviewing district leadership secondary source documents, and researcher journal notes aided in the data triangulation and analysis. This study was guided by one main research question: What are the different ways elementary assistant principals experience mentoring from their elementary …


Kiah House Museum Student Art Collection, Zach S. Henderson Library Special Collections Jan 2023

Kiah House Museum Student Art Collection, Zach S. Henderson Library Special Collections

Finding Aids

This collection consists of student artwork associated with the educational mission of the former Kiah House Museum in Savannah, Georgia. The majority of works were created from the 1940s to 1970s as part of the National Conference of Artists traveling show, an international art exchange program, in which the Kiah House Museum participated as a chapter as well as other traveling exhibitions. This collection also contains digital image files of the recovered artwork.

Find this collection in the University Libraries' catalog.


Graduate Catalog, Georgia Southern University Jan 2023

Graduate Catalog, Georgia Southern University

Graduate Catalogs

No abstract provided.


Review Of Factors Resulting In Systemic Biases In The Screening, Assessment, And Treatment Of Individuals At Clinical High-Risk For Psychosis In The United States, Miranda A Bridgwater, Emily Petti, Maksim Giljen, Leeann Akouri-Shan, Joseph S Deluca, Pamela Rakhshan Rouhakhtar, Caroline Millar, Nicole R Karcher, Elizabeth A Martin, Jordan Devylder, Deidre Anglin, Raquel Williams, Lauren M Ellman, Vijay A Mittal, Jason Schiffman Jan 2023

Review Of Factors Resulting In Systemic Biases In The Screening, Assessment, And Treatment Of Individuals At Clinical High-Risk For Psychosis In The United States, Miranda A Bridgwater, Emily Petti, Maksim Giljen, Leeann Akouri-Shan, Joseph S Deluca, Pamela Rakhshan Rouhakhtar, Caroline Millar, Nicole R Karcher, Elizabeth A Martin, Jordan Devylder, Deidre Anglin, Raquel Williams, Lauren M Ellman, Vijay A Mittal, Jason Schiffman

2020-Current year OA Pubs

BACKGROUND: Since its inception, research in the clinical high-risk (CHR) phase of psychosis has included identifying and exploring the impact of relevant socio-demographic factors. Employing a narrative review approach and highlighting work from the United States, sociocultural and contextual factors potentially affecting the screening, assessment, and service utilization of youth at CHR were reviewed from the current literature.

RESULTS: Existing literature suggests that contextual factors impact the predictive performance of widely used psychosis-risk screening tools and may introduce systemic bias and challenges to differential diagnosis in clinical assessment. Factors reviewed include racialized identity, discrimination, neighborhood context, trauma, immigration status, gender …


Machine Learning Based Pcb/Package Stack-Up Optimization For Signal Integrity, Wenchang Huang, Jiahuan Huang, Minseok Kim, Bumhee Bae, Chulsoon Hwang, Subin Kim Jan 2023

Machine Learning Based Pcb/Package Stack-Up Optimization For Signal Integrity, Wenchang Huang, Jiahuan Huang, Minseok Kim, Bumhee Bae, Chulsoon Hwang, Subin Kim

Electrical and Computer Engineering Faculty Research & Creative Works

PCB/package stack-up design optimization is time-consuming and requiring a great deal of experience. Although some iterative optimization algorithms are applied to implement automatic stack-up design, evaluating the results of each iteration is still time-intensive. This paper proposes a combined Bayesian optimization-artificial neural network (BO-ANN) algorithm, utilizing a trained ANN-based surrogate model to replace a 2D cross-section analysis tool for fast PCB/package stack-up design optimization. With the acceleration of ANN, the proposed BO-ANN algorithm can finish 100 iterations in 40 seconds while achieving the target characteristic impedance. To better generalize the BO-ANN algorithm, a strategy of effective dielectric calculation is applied …


Development Of A Matlab-Based Structural Analysis Toolbox For Sensor Placement In A Multi-Domain Physical System, Arnold A. Fernandes, Kartikeya J.P. Veeramraju, Jonathan W. Kimball Jan 2023

Development Of A Matlab-Based Structural Analysis Toolbox For Sensor Placement In A Multi-Domain Physical System, Arnold A. Fernandes, Kartikeya J.P. Veeramraju, Jonathan W. Kimball

Electrical and Computer Engineering Faculty Research & Creative Works

This paper discusses a Bond Graph (BG) Structural Analysis Toolbox developed in MATLAB® (MATSAT) that performs causal analysis on the BG and assists the user in the sensor selection process for a multi-domain physical system. MATSAT contains modules for performing the Sequential Causality Assignment Procedure (SCAP) and Causal Path Search (CaPS). The modules can be combined to check for structural properties such as structural observability (SO) for any sensor set. The working of MATSAT is shown for standard systems. Verification of SCAP, CaPS, and necessary and sufficient SO conditions is shown.


Coaxial Cable Sensing: Review And Perspective, Chen Zhu, Jie Huang Jan 2023

Coaxial Cable Sensing: Review And Perspective, Chen Zhu, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

The development of sensors has been a hot research topic in both scientific and industrial communities over the past decades. In recent years, a new sensing technology based on coaxial cables has emerged. Inspired by the fiber Bragg grating and motivated by the demand for structural health monitoring, coaxial cable Bragg gratings were first proposed and demonstrated with superior large strain capability ($>$ 5%). Mimicking the mature sensing modalities in fiber-optic sensors, coaxial cable sensors are developed to be promising alternatives for fiber-optic sensors in harsh-environment applications involving heavy duty, large strains, high pressures, and high temperatures. Over the …


The Partial Elements Equivalent Circuit Method: The State Of The Art, Giulio Antonini, Albert E. Ruehli, Daniele Romano, Fabrizio Loreto Jan 2023

The Partial Elements Equivalent Circuit Method: The State Of The Art, Giulio Antonini, Albert E. Ruehli, Daniele Romano, Fabrizio Loreto

Electrical and Computer Engineering Faculty Research & Creative Works

This year marks about half a century since the birth of the technique known as the partial element equivalent circuit modeling approach. This method was initially conceived to model the behavior of interconnect-type problems for computer-integrated circuits. An important industrial requirement was the computation of general inductances in integrated circuits and packages. Since then, the advances in methods and applications made it suitable for modeling a large class of electromagnetic problems, especially in the electromagnetic compatibility (EMC)/signal and power integrity (SI/PI) areas. The purpose of this article is to present an overview of all aspects of the method, from its …


Understanding Influencers Of College Major Decision: The Uae Case, Mohammad Amin Kuhail, Joao Negreiros, Haseena Al Katheeri, Sana Khan, Shurooq Almutairi Jan 2023

Understanding Influencers Of College Major Decision: The Uae Case, Mohammad Amin Kuhail, Joao Negreiros, Haseena Al Katheeri, Sana Khan, Shurooq Almutairi

All Works

This study aims to understand and analyze what influences female students to choose a college major in the United Arab Emirates (UAE). To accomplish our target, we conducted a survey with mostly female first-year undergraduate students (N = 496) at Zayed University to understand the personal, social, and financial factors influencing students’ major choices. Further, this study also asked students to specify their actions before deciding on their major and assessed the information that could be helpful for future students to decide on their majors. Last, the study investigated how Science, Technology, Engineering, and Mathematics (STEM) students differ from other …


Examining Factors Determining The Behavioral Intention To Use Mobile Learning Systems In Higher Education: An Integrative Framework During The Covid-19 Pandemic, Nessrin Shaya, Sandra Baroudi, Laila Mohebi Jan 2023

Examining Factors Determining The Behavioral Intention To Use Mobile Learning Systems In Higher Education: An Integrative Framework During The Covid-19 Pandemic, Nessrin Shaya, Sandra Baroudi, Laila Mohebi

All Works

This paper explores mobile learning (m-learning) acceptance and use through integrating UTAUT and IS success models to examine whether quality factors (including “Information Quality,” “System Quality” and “Service Quality”) and behavioral factors (including “Performance Expectancy,” “Social Influence” and “Facilitating Conditions”) predict students’ satisfaction and their intention to use m-learning systems. Data were collected through surveys from a total of 383 higher education male and female students in the United Arab Emirates (UAE). Structural equation modelling and path analysis were employed to test the proposed research model, showing that “Information Quality,” “System Quality,” “Service Quality,” “Performance Expectancy,” “Social Influence,” “Facilitating Conditions,” …


Using Blockchain For Enabling Transparent, Traceable, And Trusted University Ranking Systems, Ammar Battah, Khaled Salah, Raja Jayaraman, Ibrar Yaqoob, Ashraf Khalil Jan 2023

Using Blockchain For Enabling Transparent, Traceable, And Trusted University Ranking Systems, Ammar Battah, Khaled Salah, Raja Jayaraman, Ibrar Yaqoob, Ashraf Khalil

All Works

Ranking systems have proven to improve the quality of education and help build the reputation of academic institutions. Each of the current academic ranking systems is based on different methodologies, criteria, and standards of measurement. Academic and employer reputations are subjective indicators of some rankings determined through surveying that is neither transparent nor traceable. The current academic ranking systems fall short of providing transparency and traceability features for both subjective and objective indicators that are used to calculate the ranking. Also, the ranking systems are managed and controlled in a centralized manner by specific entities. This raises concerns about fairness …


A Comparison Of Medical And Pharmacy Student Perspectives Of A Clinical Interprofessional Home-Visit Versus A Virtual Interprofessional Workshop, Anita B Major, Yuanyuan Zhou, Catherine L Hatfield, Kristina M Little, Natalie M Mondragon, Anne C Gill Jan 2023

A Comparison Of Medical And Pharmacy Student Perspectives Of A Clinical Interprofessional Home-Visit Versus A Virtual Interprofessional Workshop, Anita B Major, Yuanyuan Zhou, Catherine L Hatfield, Kristina M Little, Natalie M Mondragon, Anne C Gill

Faculty, Staff and Students Publications

Background: No Place Like Home is a clinical interprofessional education (IPE) activity whereby pharmacy and medical students conduct home visits under the guidance and supervision of a clinical preceptor to homebound patients.

Purpose: We examined pharmacy and medical student perceptions of mastery of interprofessional competencies during an in-person clinical home visit pre-COVID-19 pandemic versus a virtual IPE learning activity consisting of didactic and case discussions in response to the global COVID-19 pandemic.

Methods: We administered the same modified Interprofessional Collaborative Competency Attainment Survey (ICCAS) instrument, which uses a five-point Likert scale, to both the in-person and the virtual IPE students …


Corrigendum: Case Report: Selexipag In Pediatric Pulmonary Hypertension: Initiation, Transition, And Titration, Jenna M Faircloth, Neelam D Bhatt, Corey A Chartan, Ryan D Coleman, Natalie Villafranco, Fadel E Ruiz, Raysa Morales-Demori, Elise Whalen, Erin Ely, Rozmeen Fombin, Nidhy P Varghese Jan 2023

Corrigendum: Case Report: Selexipag In Pediatric Pulmonary Hypertension: Initiation, Transition, And Titration, Jenna M Faircloth, Neelam D Bhatt, Corey A Chartan, Ryan D Coleman, Natalie Villafranco, Fadel E Ruiz, Raysa Morales-Demori, Elise Whalen, Erin Ely, Rozmeen Fombin, Nidhy P Varghese

Faculty, Staff and Students Publications

This corrects the article "Case Report: Selexipag in pediatric pulmonary hypertension: Initiation, transition, and titration", 1050508.


Pediatric Traumatic Hemorrhagic Shock Consensus Conference Research Priorities, Robert T Russell, Melania M Bembea, Matthew A Borgman, Randall S Burd, Barbara A Gaines, Mubeen Jafri, Cassandra D Josephson, Christine M Leeper, Julie C Leonard, Jennifer A Muszynski, Kathleen K Nicol, Daniel K Nishijima, Paul A Stricker, Adam M Vogel, Trisha E Wong, Philip C Spinella Jan 2023

Pediatric Traumatic Hemorrhagic Shock Consensus Conference Research Priorities, Robert T Russell, Melania M Bembea, Matthew A Borgman, Randall S Burd, Barbara A Gaines, Mubeen Jafri, Cassandra D Josephson, Christine M Leeper, Julie C Leonard, Jennifer A Muszynski, Kathleen K Nicol, Daniel K Nishijima, Paul A Stricker, Adam M Vogel, Trisha E Wong, Philip C Spinella

Faculty, Staff and Students Publications

BACKGROUND: Traumatic injury is the leading cause of death in children and adolescents. Hemorrhagic shock remains a common and preventable cause of death in the pediatric trauma patients. A paucity of high-quality evidence is available to guide specific aspects of hemorrhage control in this population. We sought to identify high-priority research topics for the care of pediatric trauma patients in hemorrhagic shock.

METHODS: A panel of 16 consensus multidisciplinary committee members from the Pediatric Traumatic Hemorrhagic Shock Consensus Conference developed research priorities for addressing knowledge gaps in the care of injured children and adolescents in hemorrhagic shock. These ideas were …


Pediatric Traumatic Hemorrhagic Shock Consensus Conference Recommendations, Robert T Russell, Joseph R Esparaz, Michael A Beckwith, Peter J Abraham, Melania M Bembea, Matthew A Borgman, Randall S Burd, Barbara A Gaines, Mubeen Jafri, Cassandra D Josephson, Christine Leeper, Julie C Leonard, Jennifer A Muszynski, Kathleen K Nicol, Daniel K Nishijima, Paul A Stricker, Adam M Vogel, Trisha E Wong, Philip C Spinella Jan 2023

Pediatric Traumatic Hemorrhagic Shock Consensus Conference Recommendations, Robert T Russell, Joseph R Esparaz, Michael A Beckwith, Peter J Abraham, Melania M Bembea, Matthew A Borgman, Randall S Burd, Barbara A Gaines, Mubeen Jafri, Cassandra D Josephson, Christine Leeper, Julie C Leonard, Jennifer A Muszynski, Kathleen K Nicol, Daniel K Nishijima, Paul A Stricker, Adam M Vogel, Trisha E Wong, Philip C Spinella

Faculty, Staff and Students Publications

Hemorrhagic shock in pediatric trauma patients remains a challenging yet preventable cause of death. There is little high-quality evidence available to guide specific aspects of hemorrhage control and specific resuscitation practices in this population. We sought to generate clinical recommendations, expert consensus, and good practice statements to aid providers in care for these difficult patients.The Pediatric Traumatic Hemorrhagic Shock Consensus Conference process included systematic reviews related to six subtopics and one consensus meeting. A panel of 16 consensus multidisciplinary committee members evaluated the literature related to 6 specific topics: (1) blood products and fluid resuscitation for hemostatic resuscitation, (2) utilization …


Toward More Rigorous And Informative Nutritional Epidemiology: The Rational Space Between Dismissal And Defense Of The Status Quo, Andrew W Brown, Stella Aslibekyan, Dennis Bier, Rafael Ferreira Da Silva, Adam Hoover, David M Klurfeld, Eric Loken, Evan Mayo-Wilson, Nir Menachemi, Greg Pavela, Patrick D Quinn, Dale Schoeller, Carmen Tekwe, Danny Valdez, Colby J Vorland, Leah D Whigham, David B Allison Jan 2023

Toward More Rigorous And Informative Nutritional Epidemiology: The Rational Space Between Dismissal And Defense Of The Status Quo, Andrew W Brown, Stella Aslibekyan, Dennis Bier, Rafael Ferreira Da Silva, Adam Hoover, David M Klurfeld, Eric Loken, Evan Mayo-Wilson, Nir Menachemi, Greg Pavela, Patrick D Quinn, Dale Schoeller, Carmen Tekwe, Danny Valdez, Colby J Vorland, Leah D Whigham, David B Allison

Faculty, Staff and Students Publications

To date, nutritional epidemiology has relied heavily on relatively weak methods including simple observational designs and substandard measurements. Despite low internal validity and other sources of bias, claims of causality are made commonly in this literature. Nutritional epidemiology investigations can be improved through greater scientific rigor and adherence to scientific reporting commensurate with research methods used. Some commentators advocate jettisoning nutritional epidemiology entirely, perhaps believing improvements are impossible. Still others support only normative refinements. But neither abolition nor minor tweaks are appropriate. Nutritional epidemiology, in its present state, offers utility, yet also needs marked, reformational renovation. Changing the status quo …


The ‘Homework Gap’ And Academic Achievement In High School Science: An Ecological Perspective For Policymakers And Practitioners, Tianca Crocker, David Kleitsch Jan 2023

The ‘Homework Gap’ And Academic Achievement In High School Science: An Ecological Perspective For Policymakers And Practitioners, Tianca Crocker, David Kleitsch

National Youth Advocacy & Resilience Journal

Information and communication technologies (ICTs) are increasingly required within K-12 educational settings, yet the impact of youth’s access to and use of digital resources outside of the classroom on academic achievement is only beginning to be explored in the literature. This study used data from the Fragile Families & Child Wellbeing Study to assess the relationship between grades in high school science and digital equity across the learner’s ecological environment. Digital inequities experienced by school-aged youth are referred to as the homework gap. The COVID-19 pandemic placed new urgency on resolving the homework gap as millions of students shifted to …


A “Post” Pandemic(S) Village Check-In: Pulse Checks And Recommendations For A Hard Re-Set In Education, Jarvais J. Jackson, Alesia Mickle Moldavan, Anne Valauri Jan 2023

A “Post” Pandemic(S) Village Check-In: Pulse Checks And Recommendations For A Hard Re-Set In Education, Jarvais J. Jackson, Alesia Mickle Moldavan, Anne Valauri

National Youth Advocacy & Resilience Journal

Utilizing the lens of the “pandemic as portal” (Roy, 2020; Souto-Manning, 2021) and the need for a “hard re-set” (Ladson-Billings, 2021) of our current education system, this literature synthesis engages with head, health, and home to consider what a new normal could look like as we take a “village check-in” of each area. For head, we consider the systemic barriers to equitable academic achievement that have long been in place for Black and Brown students. When considering health, we look at the impact of the pandemic on teacher well-being and how this may impact their ability to teach effectively and …


Toward Modernization: Using Strategic Development To Address Deficits In The Juvenile Justice System, David A. Mcleod, Emily A. Roberts Jan 2023

Toward Modernization: Using Strategic Development To Address Deficits In The Juvenile Justice System, David A. Mcleod, Emily A. Roberts

National Youth Advocacy & Resilience Journal

The Juvenile Justice System was established on the premise of rehabilitative action for behaviors that have led youth to the criminal justice system. However, the system has increasingly moved away from this original concept toward a punitive model. The authors present how this movement resulted in the devolution of human rights for the youth involved, a decrease in public safety, and a radical departure from fiscal responsibility related to the theoretical origins of rehabilitation. Studies on topics ranging from costs of correctional centers to trauma experienced by youth in these systems, along with many others, are compared to identify specific …


Parent Education: A Key Aspect In Prevention And Intervention Of Bullying In School Communities, Kanessa M. Doss, Sherrionda H. Crawford Jan 2023

Parent Education: A Key Aspect In Prevention And Intervention Of Bullying In School Communities, Kanessa M. Doss, Sherrionda H. Crawford

National Youth Advocacy & Resilience Journal

Bullying continues to be an omnipresent public health issue in school communities, affecting children’s and adolescent’s academic success, socio-emotional well-being, and overall development. Schools play a fundamental role in addressing bullying, yet parent and community involvement is equally critical. This article explores the significance of parent education in bullying prevention and intervention within school communities. The role of schools and community stakeholders with implications for each group are discussed. Resources are provided to share with parents/caregivers and facilitate their involvement in anti-bullying initiatives within school communities. The authors offer recommendations for school communities to promote anti-bullying awareness, facilitate parent education …


Exploring Adolescent Resilience During Covid-19 In A South African Township Context, Shannon Enid Wakefield Ms, Linda Theron Prof Jan 2023

Exploring Adolescent Resilience During Covid-19 In A South African Township Context, Shannon Enid Wakefield Ms, Linda Theron Prof

National Youth Advocacy & Resilience Journal

Abstract

COVID-19 has permeated news since December 2019 and has impacted all areas of life. Despite widespread coverage of COVID-related risks, there is limited understanding of adolescent resilience in Global South contexts (e.g., Africa) and against the backdrop of COVID-19. We, therefore, conducted a qualitative secondary analysis of 79 documents (i.e., drawings and written explanations) generated by school-attending adolescents in grades eight to ten in Zamdela, South Africa, during 2020 lockdown. Using a multisystemic resilience approach, we explored what these documents revealed as resilience enabling for adolescents in a township context during COVID-19. The thematic findings highlight the importance of …


Clinical Trial Design Challenges And Opportunities For Emerging Treatments For Opioid Use Disorder: A Review, Brian D Kiluk, Bethea A Kleykamp, Sandra D Comer, Roland R Griffiths, Andrew S Huhn, Matthew W Johnson, Kyle M Kampman, Marco Pravetoni, Kenzie L Preston, Ryan Vandrey, Cecilia L Bergeria, Michael P Bogenschutz, Randall T Brown, Kelly E Dunn, Robert H Dworkin, Patrick H Finan, Peter S Hendricks, Elisabeth J Houtsmuller, Thomas R Kosten, Dustin C Lee, Frances R Levin, Aimee Mcrae-Clark, Charles L Raison, Kurt Rasmussen, Dennis C Turk, Roger D Weiss, Eric C Strain Jan 2023

Clinical Trial Design Challenges And Opportunities For Emerging Treatments For Opioid Use Disorder: A Review, Brian D Kiluk, Bethea A Kleykamp, Sandra D Comer, Roland R Griffiths, Andrew S Huhn, Matthew W Johnson, Kyle M Kampman, Marco Pravetoni, Kenzie L Preston, Ryan Vandrey, Cecilia L Bergeria, Michael P Bogenschutz, Randall T Brown, Kelly E Dunn, Robert H Dworkin, Patrick H Finan, Peter S Hendricks, Elisabeth J Houtsmuller, Thomas R Kosten, Dustin C Lee, Frances R Levin, Aimee Mcrae-Clark, Charles L Raison, Kurt Rasmussen, Dennis C Turk, Roger D Weiss, Eric C Strain

Faculty, Staff and Students Publications

Importance: Novel treatments for opioid use disorder (OUD) are needed to address both the ongoing opioid epidemic and long-standing barriers to existing OUD treatments that target the endogenous μ-opioid receptor (MOR) system. The goal of this review is to highlight unique clinical trial design considerations for the study of emerging treatments for OUD that address targets beyond the MOR system. In November 2019, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the US Food and Drug Administration sponsored a meeting to discuss the current evidence regarding potential treatments for OUD, including cannabinoids, …


The Effect Of Multi-Material Architecture On The Ex Vivo Osteochondral Integration Of Bioprinted Constructs, Matthew L Bedell, Ziwen Wang, Katie J Hogan, Angelica L Torres, Hannah A Pearce, Letitia K Chim, K Jane Grande-Allen, Antonios G Mikos Jan 2023

The Effect Of Multi-Material Architecture On The Ex Vivo Osteochondral Integration Of Bioprinted Constructs, Matthew L Bedell, Ziwen Wang, Katie J Hogan, Angelica L Torres, Hannah A Pearce, Letitia K Chim, K Jane Grande-Allen, Antonios G Mikos

Faculty, Staff and Students Publications

Extrusion bioprinted constructs for osteochondral tissue engineering were fabricated to study the effect of multi-material architecture on encapsulated human mesenchymal stem cells’ tissue-specific matrix deposition and integration into an ex vivo porcine osteochondral explant model. Two extrusion fiber architecture groups with differing transition regions and degrees of bone- and cartilage-like bioink mixing were employed. The gradient fiber (G-Fib) architecture group showed an increase in chondral integration over time, 18.5 ± 0.7 kPa on Day 21 compared to 9.6 ± 1.6 kPa on Day 1 for the required peak push-out force, and the segmented fiber (S-Fib) architecture group did not, which …


Dantrolene Inhibits Lysophosphatidylcholine-Induced Valve Interstitial Cell Calcific Nodule Formation Via Blockade Of The Ryanodine Receptor, Christopher B Sylvester, Farshad Amirkhosravi, Angelina S Bortoletto, William J West, Jennifer P Connell, K Jane Grande-Allen Jan 2023

Dantrolene Inhibits Lysophosphatidylcholine-Induced Valve Interstitial Cell Calcific Nodule Formation Via Blockade Of The Ryanodine Receptor, Christopher B Sylvester, Farshad Amirkhosravi, Angelina S Bortoletto, William J West, Jennifer P Connell, K Jane Grande-Allen

Faculty, Staff and Students Publications

Calcific aortic valve disease (CAVD), a fibrocalcific thickening of the aortic valve leaflets causing obstruction of the left ventricular outflow tract, affects nearly 10 million people worldwide. For those who reach end-stage CAVD, the only treatment is highly invasive valve replacement. The development of pharmaceutical treatments that can slow or reverse the progression in those affected by CAVD would greatly advance the treatment of this disease. The principal cell type responsible for the fibrocalcific thickening of the valve leaflets in CAVD is valvular interstitial cells (VICs). The cellular processes mediating this calcification are complex, but calcium second messenger signaling, regulated …


Protocol Of Detection Of West Nile Virus In Clinical Samples, Hephzibah Nwanosike, Freedom M Green, Kristy O Murray, Jill E Weatherhead, Shannon E Ronca Jan 2023

Protocol Of Detection Of West Nile Virus In Clinical Samples, Hephzibah Nwanosike, Freedom M Green, Kristy O Murray, Jill E Weatherhead, Shannon E Ronca

Faculty, Staff and Students Publications

West Nile virus (WNV) is one of the leading causes of arboviral encephalitis in the United States but is often underdiagnosed. Despite the wide breadth of WNV-induced clinical disease syndromes, many of the symptoms associated with WNV are nonspecific at the time of presentation; thus, choosing the right diagnostic tool is essential to not only understand the true burden of disease but also provide pathogen-directed interventions for WNV-infected patients. In this chapter, we briefly discuss the three most common types of diagnostic methods for WNV in human clinical samples: nucleic acid detection, enzyme-linked immunoassay (ELISA), and plaque reduction neutralization test …


Improving Communication Between The Emergency Department And Prehospital Emergency Medical Services Through The Use Of A Secure Messaging Application: A Quality Improvement Project, Jacob G. Petlon Jan 2023

Improving Communication Between The Emergency Department And Prehospital Emergency Medical Services Through The Use Of A Secure Messaging Application: A Quality Improvement Project, Jacob G. Petlon

Master's Theses and Capstones

Background: Communication between emergency medical services (EMS) and the emergency department (ED) is a key part of treating patients being transported by ambulance. This communication is moving away from traditional radio and cell phone calls to the use of secure text-based apps. These apps can generate metrics and provide real time location information that is not available using traditional methods. Increased use of these apps can improve communication between EMS and receiving EDs.

Local Problem: Wildcat hospital introduced the EMS communication app Twiage in May of 2023. There is low utilization of the app and some EMS and ED …


Establishing A Protocol To Address Workplace Violence And Increase The Perceptions Of Safety Among Emergency Department Nurses: A Quality Improvement Initiative, Devan M. Robidoux Jan 2023

Establishing A Protocol To Address Workplace Violence And Increase The Perceptions Of Safety Among Emergency Department Nurses: A Quality Improvement Initiative, Devan M. Robidoux

Master's Theses and Capstones

Background: Violence against emergency department nurses has become a widespread phenomenon that can greatly impact a nurse's job satisfaction and performance. Research has been scarce in examining the relationship between workplace violence and its underlying consequences. There remains a disconnect between precursors of violence against nurses perpetrated by patients and the cultural expectation that violence is a part of the nurses job and, subsequently, what they signed up for when going into the field. Nurses learn that having a greater understanding of the value in the lived experience of their patients leads to better quality delivery of care. However, culturally …