Digital Commons Network^™

Shaping Policy And Practice: Analyzing The Reach Of Highly Cited And High Altmetrics Publications For Broader Impact On Physical Activity, Andrea Ramírez Varela, Natalicio Serrano, Juliana Mejía Grueso, Anita Nguyen, Deborah Salvo, Ross C Brownson, Adrian Bauman, Rodrigo Reis, Pedro Hallal, Michael Pratt

Faculty, Staff and Student Publications

BACKGROUND: A significant gap remains between the availability of physical activity (PA) evidence-based interventions and their application in real-world settings in policy and practice areas. This study aims to describe highly cited and high altmetrics publications in PA research and explore their impact on PA policy and practice.

METHODS: Mixed-methods sequential explanatory study including the identification and description of the top highly cited and high altmetrics PA publications from the last 10 years (including study design, population, type of PA study, number of citations, and altmetrics score), and interviews with key informants regarding research dissemination and implications on PA policy …

Analyzing Extracellular Vesicles For Disease Monitoring In Metastatic Colorectal Cancer Patients, Vahid Bahrambeigi

Dissertations and Theses (Open Access)

Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States. Metastases are the main cause of cancer-related death, and the most frequent metastatic sites in patients with CRCs are liver and lung. To confirm the diagnosis of metastatic CRC (mCRCs) and to classify mCRCs, tumor biopsy of a suspected metastasis is often required. The consensus molecular subtype (CMS) classification which is based on gene expression profiles of CRC tumor specimens, is a predictive factor for treatment outcomes of standard chemotherapies for mCRCs. The practicality of repeated tumor biopsies for disease monitoring in mCRC patients is …

Genomic Characterization Of Adolescent And Young Adult Cancers: Investigation Of Ewing Sarcoma Susceptibility And Chornobyl Thyroid Tumors, Olivia Lee

Dissertations and Theses (Open Access)

Adolescent and young adult (AYA) cancers, diagnosed between the ages of 15 and 39, can exhibit distinctive genetic and molecular characteristics. Reported epidemiologic findings and treatment outcomes based on pediatric and adult cancer studies are often not suitable for application to the AYA population, underscoring the need for more thorough genomic research. Advances in sequencing technologies have enabled comprehensive analyses of complex genomic characteristics of AYA cancers, crucial for understanding the underlying biology of these malignancies. Here, I have utilized advanced sequencing techniques and integrated analytic approaches to describe important genomic features in two different AYA cancer types: Ewing Sarcoma …

Oncogenic Kras And Telomere Biology In Crc Progression, Ronald Depinho

Dissertations and Theses (Open Access)

While colorectal cancer (CRC) patients diagnosed with localized stage disease (as defined by SEER) have a 5-year survival rate of 90%, this rate plunges to 14% for patients diagnosed with metastatic CRC. Consequently, there is an immediate imperative to elucidate the mechanisms that drive the transition to advanced CRC.

Human CRCs carrying oncogenic mutations in the KRAS oncogene, henceforth referred to as KRAS*, exhibit a 25% higher propensity for developing liver metastases. Similarly, in our CRC mouse model, engineered with an inducible Kras* transgene and conditional null alleles of Apc and Tp53 (referred to as iKAP), KRAS* has been …

The Federal Government's Role In Local Policing, Farhang Heydari, Barry Friedman, Rachel Harmon

Vanderbilt Law School Faculty Publications

For far too long, the federal government has failed to exercise its constitutional authority to mitigate the harms imposed by local policing. Absent federal intervention, though, some harmful aspects of policing will not be addressed effectively, or at all. States and localities often lack the necessary capacity and expertise to change policing, and many states and localities lack the will. This Article argues for federal intervention and describes what that intervention should look like.

The Article begins by describing three paradigmatic areas of local policing that require federal intervention to create real change: excessive use offorce, racial discrimination, and the …

Election Administration As A Licensed Profession, Ganesh Sitaraman, Kevin M. Stack

Vanderbilt Law School Faculty Publications

This Essay argues that election administrators should be subject to a professional licensing regime, much like licensing in medicine and law. Making election administration a licensed profession would not only expand requirements for training, but also enhance the professional identification of these officials, reinforcing norms of integrity and impartiality. By raising barriers to entry, licensing would make it more costly for partisans to obtain these offices. Licensing could also improve public confidence in the professionalism of election administration. Such a reform meets our moment. While many states have increased training requirements for election administrators, significant gaps remain. Moreover, existing reforms …

Sentencing In An Era Of Plea Bargains, Jeffrey Bellin, Jeenia I. Turner

Vanderbilt Law School Faculty Publications

The literature offers inconsistent answers to a question that is foundational to criminal law: Who imposes sentences? Traditional narratives place sentencing responsibility in the hands of the judge. Yet, in a country where 95% of criminal convictions come from guilty pleas (not trials), modern American scholars center prosecutors who control plea terms as the deciders of punishment. This Article highlights and seeks to resolve the tension between these conflicting narratives by charting the pathways by which sentences are determined in a system dominated by plea bargains. After reviewing the empirical literature on sentence variation, examining state and federal plea-bargaining rules …

Investigating The Critical Literacy Practices Of Adult Learners: A Case Study Of Four Leveled Reading Courses At A Community College, Anna Fontaine

Dissertations

This study investigates the critical literacy practices of adult learners at a community college. Student participants were selected from four different leveled reading courses. In this study, four guiding questions were adopted from Klenner and Sandretto (2011): (1) How do students make personal connections to text?; (2) In what ways do students identify multiple points of view in the text?; (3) In what ways do students identify where people in the text and included or excluded from social situations?; (4) In what ways do students discuss the influences the text has had on their views of society? These four questions …

Trash, Fragments, And Breaking Things: Toward A Grotesque Cripistemology For Disabled Life Writing, Michelle Anne Lloyd

All Dissertations

Despite the boom of memoirs of mental health post-1997 and the first advertisements for Prozac, most of them follow the same formula and come from the same places of privilege. This privilege is evident in the author bios on the books themselves and the careers of the writers. The popularity of these books within both abled and disabled realms has therefore created a script that those with mental illnesses are expected to abide by. Following in the example of Margaret Price, Katie Rose Guest Pryal, Merri Lisa Johnson, and others, I resituate mental illness as mental disability and place it …

Biochemical And Kinetic Analysis Of Phosphofructokinase In The Eukaryotic Human Pathogen Entamoeba Histolytica, Jin Cho

All Dissertations

Entamoeba histolytica is a water- and food-borne intestinal parasite that causes amoebiasis and liver abscess in ~100 million people each year leading to ~100,000 deaths. This amitochondriate parasite lacks many metabolic pathways including the tricarboxylic acid cycle and oxidative phosphorylation, and cannot synthesize purines, pyrimidines, or most amino acids. As a result, E. histolytica is presumed to rely on its modified pyrophosphate (PP_i)-dependent glycolytic pathway for ATP production during growth on glucose. This pathway relies on a PP_i-dependent rather than ATP-dependent phosphofructokinase (PFK) and thus has a net production of three ATP per glucose. However, in …

An Evaluation Of Clemson University’S Cooperative Extension Services Online Learning Programs And Framework For Program Development And Evaluation, Christina Leard

All Dissertations

The COVID-19 pandemic brought online learning to the forefront with the need to define online learning with best practices. Clemson University Extension conducted a retrospective observational study compiling survey data from virtual extension agents and supervisor’s conducting online programs. A literature review analyzed terminology for online learning to obtain a standardized definition to define online learning for Clemson Extension Services programs; evaluate and identify through literature strengths, weaknesses, opportunities, and challenges (SWOC) of on-line learning; determine and identify online learning competencies for instructors, assessment and evaluation; and analyze and evaluate response data from virtual extension agents delivering online programs in …

Exploring Modalities Of Productivity And Critical Quality Attributes In Fed-Batch Chinese Hamster Ovary Cell Cultures, Stephanie Klaubert

All Dissertations

Chinese hamster ovary (CHO) cells are among the most commonly used mammalian cell lines for the production of recombinant therapeutic proteins due to ease of culturing and humanlike post-translational modification capabilities. However, when compared to microbial systems, CHO cell line growth and productivity is relatively low. As the demand for monoclonal antibody (mAb) treatments continues to rise, it is critical to explore modalities for improved growth and productivity in CHO cell cultures, with the goal of increased protein concentrations and maintained product quality. Though some mechanisms for improved productivity, including temperature and cell culture media formulations, are relatively well understood; …

Engineering Next-Generation Cardiovascular Therapies, Ryan Walker Barrs

All Dissertations

Cardiovascular diseases are the leading cause of death worldwide. Heart disease, in particular, accounted for 1 in every 5 deaths in the United States in 2021, representing a substantial public health burden that will require more effective treatment options to alleviate. Heart transplant surgery is currently the only option to completely restore cardiac function, but many patients die while waiting for a transplant due to a longstanding organ donor shortage. Thus, there is a dire need for accessible treatment options that can repair damaged hearts. Recent advances in tissue engineering and regenerative medicine have accelerated the development of therapies for …

Experimental And Computational Platforms For Studying Systems Mechanobiology, Brendyn Miller

All Dissertations

Mechanical stimulation through physical activity has been shown to play an important role in treating and preventing several non-communicable diseases such as hypertension, lower back pain (LBP), type-2 diabetes mellitus, and several cancers. This is accomplished through the regulation of cellular behavior and tissue remodeling within the body at both the micro- and macro-scale levels. The goal of mechanobiology research is to gain in-depth knowledge and understanding of how cells sense physical forces in conjunction with other biochemical cues and translate those factors into important biological functions that either maintain tissue homeostasis or lead to pathological states. Understanding these processes …

Cellular Mechanism Of Pentagalloyl Glucose-Mediated Prevention And Reversal Of Abdominal Aortic Aneurysms, Greg Halsey

All Dissertations

Abdominal aortic aneurysm (AAA) has been the 15th leading cause of death in persons older than 55 for the past ten years in several Western countries, with rupture resulting in an almost 100% mortality rate. AAA is a focal dilation of the aorta characterized by progressive loss of elastin and vascular smooth muscle cells (SMCs), as well as persistent inflammatory response [1]. The only treatment for AAA is surgery; however, the mortality post-procedure is still 1-4%, with a 15-30% chance of morbidity [2].

Pentagalloyl glucose (PGG) treatment is effective in the reversal of AAA. While its stabilizing interactions with extracellular …

Addressing Mercury Contamination From Artisanal Gold Mining In Colombia: Pollution Exposure, Health Risk, And Educational Efforts In The Communities Of La Toma, Colombia, Kelli Mccourt

All Dissertations

Artisanal and small-scale gold mining (ASGM) has become a primary environmental and public health concern in the region of Colombia known as Alto Cauca. The predominantly Afro-descendent communities of Yolombó and La Toma in Alto Cauca have experienced pollution linked to the use of mercury in the ASGM process. For the past decade, mercury has emerged as a contaminant of increasing concern in the communities due to its toxicity and ability to bioaccumulate and biomagnify. Likewise, mining in the region raises concerns over the leaching of metals into local waters. Given the complexity of risk and pollution in the communities, …

Leveraging Professional Learning To Impact Leadership Of Technology Integration, Tennille Woodward

All Dissertations

School and district leaders lack awareness of the depth and complexity of the International Society for Technology in Education (ISTE) Standards for Education Leaders and how the implementation of the leader standards provides for students and teachers to learn relevant skills and strategies. Continuing the work of Schoenbart’s 2019 dissertation, the Education Leaders Technology Survey (ELTS) provides a self-assessment for education leaders to reflect on their leadership of technology integration and provides baseline data for this study. Professional learning around the ISTE Standards for Education Leaders provided through a Canvas course provides education leaders with a theory of action to …

Influence Of Photoreactor Design Parameters On The Performance Of Ultraviolet Light-Induced Degradation Of Per-And Polyfluoroalkyl Substances By Bismuth Oxy Hydroxy Phosphate And Hexagonal Boron Nitride Photocatalystsinfluence Of Photoreactor Design Parameters On The Performance Of Ultraviolet Light-Induced Degradation Of Per-And Polyfluoroalkyl Substances By Bismuth Oxy Hydroxy Phosphate And Hexagonal Boron Nitride Photocatalysts, Mojtaba Qanbarzadeh

All Dissertations

The main objective of this study is to evaluate the practical applicability of heterogeneous photocatalysis technology powered by ultraviolet (UV) photons for the degradation of per and -polyfluoroalkyl substances (PFAS) in contaminated groundwater samples. For this purpose, bismuth oxyhydroxy phosphate (BOHP) and hexagonal boron nitride (hBN) were utilized as the main photocatalysts in slurry photodegradation systems. BOHP (Bi₃O(OH)(PO₄)₂) is a wide bandgap semiconductor with high activity for degrading long-chain perfluorocarboxylic acids (PFCAs) in mild operational conditions. Boron nitride (BN) is another wide bandgap semiconductor material that was used in this study due to its …

The Effect Of Prior Virtual Reality Experience On Locomotion And Navigation In Virtual Environments, Moloud Nasiri

All Dissertations

VirtualReality(VR) is becoming more accessible and widely utilized in crucial disciplines like training, communication, healthcare, and education. One of the important parts of VR applications is walking through virtual environments. So, researchers have broadly studied various kinds of walking in VR as it can reduce sickness, improve the sense of presence, and enhance the general user experience. Due to the recent availability of consumer Head Mounted Displays (HMDs), people are using HMDs in all sorts of different locations. It underscores the need for locomotion methods that allow users to move through large Immersive Virtual Environments (IVEs) when occupying a small …

Expanding On The Frames: Making A Case For Algorithmic Literacy, Susan G. Archambault

Communications in Information Literacy

Traditional information literacy skills (e.g., effectively finding and evaluating information) need to be updated due to the rapidly changing information ecosystem and the growing dominance of online platforms that use algorithms to control and shape information. This article proposes additions to the current ACRL Framework for Information Literacy for Higher Education that relate to algorithmic literacy. The “Authority Is Constructed and Contextual” frame can be applied to recognizing the need to question algorithmic authority (including algorithmic bias), the "Information Has Value” frame can be used to acknowledge online platforms’ use of proprietary algorithms allowing third parties to access personal data, …

United States Social Security Administration Response To The Office Of Science And Technology Policy Memo, 2022: Public Access Plan (December 2023)

Copyright, Fair Use, Scholarly Communication, etc.

SSA response to OSTP memo, 2022: Public Access Plan (December 2023)

Domestic Violence In Sioux County: Raising Awareness And Stimulating Empathy, Jenna Aalbers, Bailey Brown, Kenzie Kurtz, Linden Sutton

Student Projects

Domestic violence is a pertinent problem in Sioux County, Iowa, yet community members tend to be unaware of its existence and relevance. That is because it operates in a sly cycle, largely undetected by those outside the family. There is a general lack of public discussion and understanding about domestic violence, which tends to be viewed as a private, family matter. Despite this, the impacts of domestic violence extend beyond the family, and there are systemic factors that serve as barriers and risk factors for domestic violence survivors. This paper highlights the conditions of domestic violence in general as well …

Student Perceptions And Preferences Of University-Affiliated Athletic Merchandise And Logos, Robin Hardin, Michelle L. Childs, Kirby D. Simpson

Journal of Applied Marketing Theory

College sports are certainly ingrained in the fabric of American society, and a significant aspect of this phenomena is the pageantry associated with college sports. This pageantry includes team logos and official team colors, and both are important aspects of fandom and team identification. Utilizing social identify theory as the theoretical framework for this research, the purpose of this study was to examine students’ university-affiliated athletic merchandise and logo preferences and related behaviors. Two focus groups were conducted with results showing three major themes, where students demonstrated polarizing views and opinions. These themes were (a) fashion and function, (b) orientation …

Real But Fictional: A Research Agenda Of Virtual Influencers For Brand Communications In Social Media Marketing, Lei Huang

Journal of Applied Marketing Theory

With the rise of virtual influencers (VIs) and their impacts on influencer marketing, this paper proposes a future research paradigm on how to develop brand communication strategies through a novel understanding of VIs from both the consumer and company perspectives. Built on the parasocial interaction theory and the human brand theory, six propositions aim to provide research guidelines for influencer and social media marketing by leveraging the use of VIs in a brand-consumer relationship. The theoretical and managerial implications are also discussed.

Comments From The Editors, Tulay Girard, Melek Meral Anitsal

Journal of Applied Marketing Theory

Comments from the Editors:

We welcome you to the current issue of the Journal of Applied Marketing Theory. The Journal of Applied Marketing Theory (JAMT) aims to provide a reputable platform for publishing academic research that advances marketing knowledge and offers insights for marketing managers.

In the current issue, we are pleased to present six manuscripts that offer unique insights into several diverse topics. Each article received praise from our review team and we are happy to have the opportunity to present them to you in this edition of JAMT.

Digital Vs. Traditional: Comparing Sales Students' Initial Post- College Career Search Preferences Before And After Covid-19, Linda Mullen, Randy Stuart, Michael L. Thomas

Journal of Applied Marketing Theory

This study explores the impact of the COVID-19 pandemic on the

career search strategies of college students studying professional

sales. The research consists of a post-pandemic study that is

compared to a previous study conducted pre-pandemic in 2019. The

paper investigates the preference of sales students for digital

media versus face-to-face interactions in their career searches.

The pre-pandemic study revealed that while sales students

engaged with digital media, they still heavily relied on traditional

methods. The post-pandemic results differed primarily in students’

interviewing preferences. Despite the challenges posed by the

pandemic, students continue to utilize both online and traditional

resources. …

Through The Lens Of A Naturalist: How Learning About Nature Promotes Nature Connectedness Via Awe, Shu Tian Ng, Angela K. Y. Leung, Sarah Hian May Chan

Research Collection School of Social Sciences

Environmental educators stress the importance of engaging with the wonders of the Earth in promoting nature connectedness. However, it remains unclear if learning about nature has an incremental effect beyond mere exposure to nature and what psychological mechanism can explain such a learning effect if it exists. To fill this gap, we propose a mediation model in which learning about nature promotes a sense of awe—a self-transcendent emotion associated with the recognition of vastness in nature. A sense of awe, in turn, promotes nature connectedness. Study 1 employed a cross-sectional survey and offered preliminary support for the proposed model, with …

Challenges Of Ethnic Party Adaptation In Power-Sharing Systems: Evidence From Malaysia, Sebastian Carl Dettman

Research Collection School of Social Sciences

In authoritarian systems, ethnic power-sharing arrangements include important ethnic groups in government and decision-making while putting restraints on political competition. However, under conditions of democratization, we might expect power-sharing arrangements to fragment as political parties seize opportunities to expand their base and appeal across ethnic lines. This article draws from the case of Malaysia, where multiethnic coalitions built around ethnic parties ruled for 61 years but where increasing electoral competitiveness has destabilized coalition politics. I focus on the Democratic Action Party (DAP), one of the country's most successful parties, which has sought to build a more multiethnic support base. I …

When Social Status Gets In The Way Of Mating: The Incompatibility Between Social Status And Reproductive Goals In Modern Contexts, Jose C. Yong, Amy J. Y. Lim, Norman P. Li

Research Collection School of Social Sciences

Low fertility is a growing concern in modern societies. While economic and structural explanations of reproductive hindrances have been informative to some extent, they do not address the fundamental motives that underlie reproductive decisions and are inadequate to explain why East Asian countries, in particular, have such low fertility rates. The current paper advances a novel account of low fertility in modern contexts by describing how modern environments produce a mismatch between our evolved mechanisms and the inputs they were designed to process, leading to preoccupations with social status that get in the way of mating and reproductive outcomes. We …

Low Reynolds Number Locomotion Near Interfaces In Two-Fluid Media, Avriel Rowena Mae Cartwright

Theses and Dissertations

Microorganisms often swim within complex fluid environments composed of multiple materials with very different properties. Biological locomotion, including swimming speed, is significantly impacted by the physical composition and rheology of the surrounding fluid environment, as well as the presence of phase boundaries and free interfaces, across which physical properties of the fluid media may vary greatly. Through computational simulations, we first investigate the classical Taylor’s swimming sheet problem near interfaces within multi-fluid environments using a two-fluid immersed boundary method. The accuracy of the methodology is illustrated through comparisons with analytical solutions. Our simulation results indicate that the interface dynamics and …