Digital Commons Network^™

Portable Smart Emergency System Using Internet Of Things (Iot), Batool Jamal, Muneera Alsaedi, Parag Parandkar

Mesopotamian Journal of Big Data

The portable smart emergency system is a pre-test tool, implemented using a set of modern devices and technologies to monitor the patient's health. This tool has capability to send reports of the patient to the doctor treating the patient as well as to the relatives, close friends of the patient in real time. Health parameters of the patient viz. heart rate, blood oxygen and temperature are monitored using electronic devices viz. WEMOS D1, MAX30100, DS18B20, SIM808 on the LCD screen and stored using the MySQL database. PHP script is used to connect MySQ database for easy tracking and analysis of …

From Machine Learning To Artificial General Intelligence: A Roadmap And Implications, Omar Ibrahim Obaid

Mesopotamian Journal of Big Data

The prospect of developing artificial general intelligence (AGI) with the same comprehensive capabilities as the human mind presents humanity both tremendous opportunities and dire risks. This paper explores the potential applications and implications of AGI across diverse domains including science, healthcare, education, security, and the economy. However, realizing AGI's benefits requires proactive alignment of its goals and values with those of humanity through responsible governance. As AGI approaches and possibly surpasses human-level intellectual abilities, we must grapple with complex ethical issues surrounding autonomy, consciousness, and disruptive societal impacts. The exact timeline for achieving AGI remains uncertain, but its emergence will …

Tennessee Farm Bureau News - January 2023, Tennessee Farm Bureau Federation

Tennessee Farm Bureau News

No abstract provided.

Climate Changes Through Data Science: Understanding And Mitigating Environmental Crisis, Ahmed Hussein Ali, Rahul Thakkar

Mesopotamian Journal of Big Data

Climate change represents an urgent environmental crisis with far-reaching risks to ecosystems and human communities worldwide. Rapid development of mitigation strategies and solutions is imperative but relies profoundly on advancements in detection, attribution, and prediction derived from climate data analytics. This paper examines the growing role of data science in not only quantifying anthropogenic climate change but also informing impact assessment and targeted intervention across climate-sensitive sectors. First, we survey established and emerging techniques for climate characterization, including machine learning applications on Earth systems data. Next, we discuss how sophisticated climate models alongside statistical analysis of multi-domain datasets—from migration patterns …

Powerful, Scalable And Resource-Efficient Meta-Analysis Of Rare Variant Associations In Large Whole Genome Sequencing Studies, Xihao Li, Corbin Quick, Hufeng Zhou, Sheila M. Gaynor, John Blangero, Joanne E. Curran, Ravindranath Duggirala, Harald H. H. Goring, Michael Mahaney, Juan M. Peralta

School of Medicine Publications

Meta-analysis of whole genome sequencing/whole exome sequencing (WGS/WES) studies provides an attractive solution to the problem of collecting large sample sizes for discovering rare variants associated with complex phenotypes. Existing rare variant meta-analysis approaches are not scalable to biobank-scale WGS data. Here we present MetaSTAAR, a powerful and resource-efficient rare variant meta-analysis framework for large-scale WGS/WES studies. MetaSTAAR accounts for relatedness and population structure, can analyze both quantitative and dichotomous traits and boosts the power of rare variant tests by incorporating multiple variant functional annotations. Through meta-analysis of four lipid traits in 30,138 ancestrally diverse samples from 14 studies of …

Serotonin Regulation Of Behavior Via Large-Scale Neuromodulation Of Serotonin Receptor Networks, Piergiorgio Salvan, Madalena Fonseca, Anderson M. Winkler, Antoine Beauchamp, Jason P. Lerch, Heidi Johansen-Berg

School of Medicine Publications

Although we understand how serotonin receptors function at the single-cell level, what role different serotonin receptors play in regulating brain-wide activity and, in turn, human behavior, remains unknown. Here, we developed transcriptomic–neuroimaging mapping to characterize brain-wide functional signatures associated with specific serotonin receptors: serotonin receptor networks (SRNs). Probing SRNs with optogenetics–functional magnetic resonance imaging (MRI) and pharmacology in mice, we show that activation of dorsal raphe serotonin neurons differentially modulates the amplitude and functional connectivity of different SRNs, showing that receptors’ spatial distributions can confer specificity not only at the local, but also at the brain-wide, network level. In humans, …

Synchronous Gastrointestinal Metastatic Large Cell Neuroendocrine Tumor And Metastatic Colon Adenocarcinoma: Case Report, Hari Movva, Giri Movva, Christian Pena, Vijian Dhevan

School of Medicine Publications

This article reports a case involving a synchronous silent metastatic rectal adenocarcinoma and metastatic large cell neuroendocrine tumor of the cecum and ascending colon. The patient presented with left sided abdominal pain and hematochezia with a noncontributory family, social, and medical history. This case presents a rare pathology not only due to the low incidence of synchronous gastrointestinal malignancies, but due to the unusual silent patient presentation.

Estrés Postraumático Y Covid-19 En América Latina: Un Llamado A La Acción/Posttraumatic Stress And Covid-19 In Latin American: A Call To Action, Alfonso Mercado, Andy Torres, Amanda Palomin, Frances Morales, Cecilia Colunga-Rodríguez, Mario Angel Gonzalez, Luis E. Sarabia-López, Gabriel Davalos-Picazo, Diemen Delgado-García, Daniel Duclos

Psychological Science Faculty Publications

The COVID-19 pandemic impacted the mental wellbeing of the entire globe. However, Latin American countries’ systemic and environmental challenges hindered the ability of many nations in the region to serve the mental health needs of its habitants. Compared to other mental health symptoms, Posttraumatic Stress Disorder Symptoms (PTSS) were particularly higher among this geographical region. Nonetheless, there is scarcity of research identifying the unique symptom profile of PTSS. Given that the typology of PTSS is multidimensional and appears to be contingent on the type of stressor, this study (as part of larger international study) aimed to identify differences in PTSS …

Learning A Healthy Rhythm: An Intervention To Increase Children’S Resources For Stress Management, Kristin Haglund, Amanda L. King, Abir K. Bekhet, Mauricio Garnier-Villarreal, Karen Olson, Rashs Atshan, Angela Ortiz, Johanna De Los Santos, Ruth Ann Belknap

College of Nursing Faculty Research and Publications

This article describes a pilot test of a community engaged, culturally relevant, arts-based intervention. The purpose was to increase children’s personal protective buffering resources. Protective buffering resources help children cope with stressful stimuli, reduce activation of their systemic stress response, mitigate allostatic load, and promote optimal health. The “Learning a Healthy Rhythm” intervention included a stress management component and an ongoing Afro-Latino percussion program for 18 children ages 9–11. The stress management component included educational content about stress, self-assessment of stress symptoms, and stress management techniques. A mixed-method intervention evaluation design was used. Qualitative data, quantitative data, and biometrics including …

A Randomized Implementation Trial To Increase Adoption Of Evidence-Informed Consent Practices, Erin D Solomon, Jessica Mozersky, Melody Goodman, Meredith V Parsons, Kari A Baldwin, Annie B Friedrich, Jenine K Harris, James M Dubois

2020-Current year OA Pubs

INTRODUCTION: Several evidence-informed consent practices (ECPs) have been shown to improve informed consent in clinical trials but are not routinely used. These include optimizing consent formatting, using plain language, using validated instruments to assess understanding, and involving legally authorized representatives when appropriate. We hypothesized that participants receiving an implementation science toolkit and a social media push would have increased adoption of ECPs and other outcomes.

METHODS: We conducted a 1-year trial with clinical research professionals in the USA (

RESULTS: Participants who engaged more with the toolkit were more likely to have tried to implement an ECP during the trial …

Predictors Of Nonadherence Among Patients With Infectious Complications Of Substance Use Who Are Discharged On Parenteral Antimicrobial Therapy, Shivakumar Narayanan, Patrick R Ching, Edward C Traver, Nivya George, Anthony Amoroso, Shyam Kottilil

2020-Current year OA Pubs

BACKGROUND: The management of invasive infections related to substance use disorder (SUD) needing parenteral antimicrobial therapy is challenging and may have poor treatment outcomes including nonadherence and lack of completion of parenteral antimicrobial therapy.

METHODS: In this retrospective cohort of 201 patients with invasive infections related to SUD, we looked at frequency and determinants of unfavorable outcomes including nonadherence.

RESULTS: Seventy-nine percent of patients with SUD-related infection completed parenteral antibiotic therapy in skilled nursing facilities. A total of 21.5% of patient episodes had documentation of nonadherence. Nonadherence was higher in patients with active injection drug use (IDU) (28.5% versus 15% …

Design Of Effisayil™ 2: A Randomized, Double-Blind, Placebo-Controlled Study Of Spesolimab In Preventing Flares In Patients With Generalized Pustular Psoriasis, Akimichi Morita, Siew Eng Choon, Hervé Bachelez, Milan J Anadkat, Slaheddine Marrakchi, Min Zheng, Tsen-Fang Tsai, Hamida Turki, Harry Hua, Sushmita Rajeswari, Christian Thoma, A David Burden

2020-Current year OA Pubs

INTRODUCTION: Generalized pustular psoriasis (GPP) is a rare autoinflammatory skin disease characterized by flares of widespread erythema with sterile pustules, and can be relapsing with recurrent flares, or persistent with intermittent flares. Spesolimab, a humanized anti-interleukin-36 (IL-36) receptor monoclonal antibody, targets the key IL-36 pathogenetic pathway in GPP. A previous study showed that spesolimab treatment led to rapid pustular and skin clearance in patients with GPP flares, which was sustained for up to 12 weeks. This study investigates the long-term effects of spesolimab on GPP flares, for which no specific treatments are currently available. The Effisayil™ 2 study will assess …

The Neurotoxin Dsp-4 Dysregulates The Locus Coeruleus-Norepinephrine System And Recapitulates Molecular And Behavioral Aspects Of Prodromal Neurodegenerative Disease, Alexa F. Iannitelli, Michael A. Kelberman, Daniel J. Lustberg, Anu Korukonda, Katharine E. Mccann, Bernard Mulvey, Arielle Segal, L Cameron Liles, Steven A. Sloan, Joseph D. Dougherty, David Weinshenker

2020-Current year OA Pubs

The noradrenergic locus coeruleus (LC) is among the earliest sites of tau and α-synuclein pathology in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively. The onset of these pathologies coincides with loss of noradrenergic fibers in LC target regions and the emergence of prodromal symptoms including sleep disturbances and anxiety. Paradoxically, these prodromal symptoms are indicative of a noradrenergic hyperactivity phenotype, rather than the predicted loss of norepinephrine (NE) transmission following LC damage, suggesting the engagement of complex compensatory mechanisms. Because current therapeutic efforts are targeting early disease, interest in the LC has grown, and it is critical to identify …

Differential Expression Of Programmed Death 1 (Pd-1) On Various Immune Cells And Its Role In Human Leprosy, Mohammad Tarique, Huma Naz, Mohd Suhail, Ali Turan, Chaman Saini, Naoshad Muhammad, Hari Shankar, Torki A Zughaibi, Tabish H Khan, Neena Khanna, Alpana Sharma

2020-Current year OA Pubs

Leprosy is a chronic bacterial disease caused by

Adaptive Leadership In Local Responses To Covi D-19: Cases Of The Cities Of Santa Rosa And Valenzuela, Philippines, Miriam Caryl Carada, Therese Pardo, Aileen Lapitan

Journal of Public Affairs and Development

The Coronavirus Disease (COVID-19) created a disruption to the global landscape that called for the quick response of key governance actors, specifically an adaptive approach by the local leaders. In this study, we analyze strategies of two local chief executives to draw insights about how adaptive leadership practiced in the context of two cities in the Philippines deemed to excel in managing the pandemic at the height of its onslaught. Owing to COVID restrictions at the time of the study, secondary data from various social media accounts, local government portals, and news websites were utilized together with the accounts from …

Agricultural Extension Services And Household Food Security Of Women Rice Farmers In The Ayeyarwady Region Of Myanmar, Yi Mon Thu, Rowena Dt. Baconguis, Myra E. David, Merlyne M. Paunlagui, Pompe C. Sta. Cruz

Journal of Public Affairs and Development

The study aimed to analyze women's households' farming practices towards household food security, particularly in six villages of the Ayeyarwady region. Data were collected from 126 randomized respondents. Findings show that the respondents are respondents who had a mean age of 45 years, married, natives of the study sites, and have attended primary education with an average of four family members. The government is the primary agency that provides training programs, mostly in rice production. They have access to extension worker visitation in which the most common topic discussed is pest management. Less than a fourth of the respondents are …

Consensus Guidelines For Sarcopenia Prevention, Diagnosis And Management In Australia And New Zealand, Jesse Zanker, Marc Sim, Kate Anderson, Saliu Balogun, Sharon L. Brennan-Olsen, Elsa Dent, Gustavo Duque, Christian M. Girgis, Mathis Grossmann, Alan Hayes, Tim Henwood, Vasant Hirani, Charles Inderjeeth, Sandra Iuliano, Justin Keogh, Joshua R. Lewis, Gordon S. Lynch, Julie A. Pasco, Steven Phu, Esmee M. Reijnierse, Nicholas Russell, Lara Vlietstra, Renuka Visvanathan, Troy Walker, Debra L. Waters, Solomon Yu, Andrea B. Maier, Robin M. Daly, David Scott

Research outputs 2022 to 2026

Background:

Sarcopenia is an age-associated skeletal muscle condition characterized by low muscle mass, strength, and physical performance. There is no international consensus on a sarcopenia definition and no contemporaneous clinical and research guidelines specific to Australia and New Zealand. The Australian and New Zealand Society for Sarcopenia and Frailty Research (ANZSSFR) Sarcopenia Diagnosis and Management Task Force aimed to develop consensus guidelines for sarcopenia prevention, assessment, management and research, informed by evidence, consumer opinion, and expert consensus, for use by health professionals and researchers in Australia and New Zealand.

Methods:

A four-phase modified Delphi process involving topic experts and informed …

Relationship Between Residential Aged Care Facility Characteristics And Breaches Of The Australian Aged Care Regulatory Standards: Non-Compliance Notices And Sanctions, Janine Alan, Sean Randall, Anna Ferrante, Davina Porock

Research outputs 2022 to 2026

Objectives

To examine the relationship between structural characteristics of Australian residential aged care facilities (RACFs) and breaches of the aged care quality standards.

Methods

Facility-level analysis of audits, sanctions and non-compliance notices of all accredited Australian RACFs between 2015/16 and 2018/19. Structural factors of interest included RACF size, remoteness, ownership type and jurisdiction. Two government data sources were joined. Each outcome was analysed to calculate time trends, unadjusted rates and relative risks.

Results

Non-compliance notices were imposed on 369 RACFs (13%) and 83 sanctions on 75 RACFs (3%). Compared with New South Wales (NSW), non-compliance notices were less likely in …

The Rural Enterprise Crime Complex: ‘Undefendable Rural Space’ And The Threat From The Fortress Farm, Orlando Goodall

School of Law, Humanities and Social Sciences

In response to the concept of the ‘fortress farm’ and its appropriation of traditional defensible space theory, this article introduces the conditions of undefendable rural space and the rural enterprise crime complex. Perspectives that invert traditional theory to determine contexts conducive to the incidence of rural enterprise crime. Empirical data from extensive fieldwork on crimes against wild animals in rural England is used to argue that the fortress and undefendable rural space can in effect serve to ‘design-out’ crime control and lock crime in. A dichotomous outcome, which creates a fortress for relatively powerful human insiders and a rural enterprise …

Implementing A Short-Term Field-Based Experiential Learning Activity: The Retail Scavenger Hunt, Pam Richardson, Rebeca Perren

Atlantic Marketing Journal

This article introduces the Retail Scavenger Hunt (RSH)—a short-term field-based experiential learning activity. This flexible pedagogical tool enables students to experience first-hand what is commonly referred to in the consumer-packaged goods industry as “the store check.” Although initially designed as an instructor-led activity, the authors adapted the exercise during the pandemic to be executed as a self-directed, app-based field activity. As a result, this research can compare student impressions across implementation modes.

Assessing The Impact Of Racist Incidents On The Community In Plymouth., Chris Pac-Soo, Emma Taylor

School of Law, Humanities and Social Sciences

This report details the findings of research, funded by the University of Plymouth, to evaluate and assess the impact of racist incidents on the community in Plymouth. It has been acknowledged by Plymouth and Devon Racial Equality Council (PDREC) that since the beginning of the Covid-19 pandemic in March 2020, they have recorded an increase in racist incidents within Plymouth, particularly in the postcode PL1 area. This research aims to provide a resource for PDREC, the local authority, agencies, and communities to address racist incidents and to provide a platform to help build resilience towards racism. The research was a …

Not Hearing, Not Engaging, And Not Happening: Elusive Inclusive Higher Education, It Is Time To Reconsider Sector Practices In Partnership With Disabled Student Expertise, Suanne Gibson, Zeta Williams-Brown, Jen Shute, Mette Westander

School of Law, Humanities and Social Sciences

This paper focuses on inclusive higher education in the United Kingdom. It details international literature, research studies and national reports, including findings from the authors’ study, ‘Working with disabled students to address unequal outcomes in UK HE during the pandemic’ where we critically explored inclusive practice in Higher Education (HE) and disabled students’ learning experiences. Our national study was carried out as a collaboration between the University of Plymouth, University of Wolverhampton, and Disabled Students UK (DSUK). Data collection took place in 2021 with an extensive literature-based investigation alongside the dissemination of a questionnaire to DSUK members resulting in 14 …

Final Report June 2023: Research Impact Evidence Scheme - Research Impact: Dr. Helen Adam, Maria Enriquez-Watt, Helen Adam

Research outputs 2022 to 2026

This research addressed the question: What is the impact of the research of Dr. Helen Adam into the culturally responsive use of diverse literature on practitioners, school communities, policy makers and the wider community?

Key Findings:

• The primary beneficiaries of Adam’s work include policy makers, educational professionals & consultants, academics, teacher trainers, and librarians.
• The secondary beneficiaries of Adam’s research include school children and their families, school communities and the wider community.
• Adam’s research is of pervasive and profound significance in educational sectors and is rapidly becoming of global significance.
• Adam’s research is transformative and impacts on the lives of …

Expanded Analysis Of High-Grade Astrocytoma With Piloid Features Identifies An Epigenetically And Clinically Distinct Subtype Associated With Neurofibromatosis Type 1, Patrick J Cimino, Sonika Dahiya, Et Al.

2020-Current year OA Pubs

High-grade astrocytoma with piloid features (HGAP) is a recently recognized glioma type whose classification is dependent on its global epigenetic signature. HGAP is characterized by alterations in the mitogen-activated protein kinase (MAPK) pathway, often co-occurring with CDKN2A/B homozygous deletion and/or ATRX mutation. Experience with HGAP is limited and to better understand this tumor type, we evaluated an expanded cohort of patients (n = 144) with these tumors, as defined by DNA methylation array testing, with a subset additionally evaluated by next-generation sequencing (NGS). Among evaluable cases, we confirmed the high prevalence CDKN2A/B homozygous deletion, and/or ATRX mutations/loss in this tumor …

Anti-Capsular Activity Of Cuo Nanoparticles Against Acinetobacter Baumannii Produce Efflux Pump, Israa M.S. Al-Kadmy, Sarah Naji Aziz, Ahmed Mahdi Rheima, Suhad Abbas Abid, Ahmed Suhail, Israa Hussein Hamzah, Eman N. Naji, Alexandros Besinis, Helal F. Hetta

School of Engineering, Computing and Mathematics

Copper oxide nanoparticles are modern kinds of antimicrobials, which may get a lot of interest in the clinical application. This study aimed to detect the anti-capsular activity of CuO nanoparticles against Acinetobacter baumannii produce efflux pump. Thirty-four different clinical A. baumannii isolates were collected and identified by the phenotypic and genetic methods by the recA gene as housekeeping. Antibiotic sensitivity and biofilm-forming ability, capsular formation were carried out. The effect of CuO nanoparticles on capsular isolates was detected, the synergistic effects of a combination CuO nanoparticles and gentamicin against A. baumannii were determined by micro broth checkerboard method, and the …

Applying Hybrid Effectiveness-Implementation Studies In Equity-Centered Policy Implementation Science, Yuka Asada, Aimee Kroll-Desrosiers, Jamie F Chriqui, Geoffrey M Curran, Karen M Emmons, Debra Haire-Joshu, Ross C Brownson

2020-Current year OA Pubs

Policy implementation science (IS) is complex, dynamic, and fraught with unique study challenges that set it apart from biomedical or clinical research. One important consideration is the ways in which policy interacts with local contexts, such as power and social disadvantage (e.g., based on ability, race, class, sexual identity, geography). The complex nature of policy IS and the need for more intentional integration of equity principles into study approaches calls for creative adaptations to existing implementation science knowledge and guidance. Effectiveness-implementation hybrid studies were developed to enhance translation of clinical research by addressing research questions around the effectiveness of an …

Proteomic Analysis Of Genetically Stratified Grade-I Meningioma, Yeasmin Akther

Peninsula Medical School Theses

Introduction: Meningioma is the most common primary intracranial tumour. Although often benign in nature, at least 20% have high rates of recurrence. Surgical resection and radiotherapy are the main therapeutic approach, yet tumour location can hamper complete resection and chemotherapies are ineffective. Therefore, more accurate prognostic biomarkers are needed to improve the clinical management of meningioma. The mutational profile of mutant meningioma is well defined, including in addition to most common NF2 loss, mutations of TRAF7, KLF4, and AKT1. The aim of this study is to identify novel biomarkers and therapeutic targets of genetically stratified meningioma by characterising the proteomic …

Elevated Liver Glycogenolysis Mediates Higher Blood Glucose During Acute Exercise In Barth Syndrome, George G. Schweitzer, Grace L. Ditzenberger, Curtis C. Hughey, Brian N. Finck, Michael R. Martino, Christina A. Pacak, Barry J. Byrne, William Todd Cade

2020-Current year OA Pubs

UNLABELLED: Barth syndrome (BTHS) is an X-linked recessive genetic disorder due to mutations in the Tafazzin (TAFAZZIN) gene that lead to cardiac and skeletal muscle mitochondrial dysfunction. Previous studies in humans with BTHS demonstrate that the defects in muscle mitochondrial oxidative metabolism result in an enhanced reliance on anaerobic metabolism during exercise to meet energy demands of muscular work. During exercise, the liver normally increases glucose production via glycogenolysis and gluconeogenesis to match the elevated rate of muscle glucose uptake and meet the ATP requirements of working muscle. However, the impact of Tafazzin deficiency on hepatic glucose production and the …

Histopathological Evaluation Of Onchocerca Volvulus Nodules By Microscopy And By Digital Image Analysis For The Study Of Macrofilaricidal Drug Efficacy, Kerstin Fischer, Bettina Dubben, Linda B Debrah, Janina M Kuehlwein, Arcangelo Ricchiuto, Alexander Y Debrah, Achim Hoerauf, Gary J Weil, Peter U Fischer, Ute Klarmann-Schulz

2020-Current year OA Pubs

BACKGROUND: Novel drugs or drug combinations that kill or permanently sterilize adult

MATERIAL AND METHODS: Two expert microscopists independently assessed 605 nodules by direct microscopy. At least two sections with two different stains hematoxylin & eosin (H&E, APR immunostain) of paraffin-embedded, ethanol-fixed whole-nodule cross-sections were analyzed. After variables were identified prone to observer discrepancies, we performed a second study to compare consolidated results for 100 nodules obtained by the two readers by microscopy and by analysis of scanned, high resolution digital images (20x magnification). The last data set analyzed was a quality panel of 100 nodules that has been previously …

Psychosocial Work Environment Stressors For School Staff During The Covid-19 Pandemic: Barriers And Facilitators For Supporting Wellbeing, Liz R Rolf, Liz Vestal, Ashley C Moore, Nikole Lobb Dougherty, Nancy Mueller, Jason G Newland

2020-Current year OA Pubs

INTRODUCTION: After periods of remote and/or hybrid learning as a result of the COVID-19 global pandemic, the return to in-person learning has been beneficial for both students and teachers, but it has not been without challenges. This study was designed to assess the impact of the return to in-person learning on the school experience, and efforts made to ease the transition in furthering a positive in-person learning environment.

MATERIALS AND METHODS: We conducted a series of listening sessions with 4 stakeholder groups: students (

RESULTS: Three main themes emerged around school staff experiences: (1) increased levels of stress and anxiety …