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2023

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Exploring Job Burnout And Engagement Amongst Construction Managers In Thailand: A Cross-Sectional Study Using Structural Equation Modelling, Thinley Lhendup Jan 2023

Exploring Job Burnout And Engagement Amongst Construction Managers In Thailand: A Cross-Sectional Study Using Structural Equation Modelling, Thinley Lhendup

Chulalongkorn University Theses and Dissertations (Chula ETD)

Studies of job burnout have gained appreciable momentum within the construction industry in the past few decades, however literature incorporating the Maslach Burnout Inventory (MBI) is still sparse. Furthermore, a single piece of literature can be traced that utilized the six Areas of Worklife Survey (AWS) as an independent variable influencing burnout among construction professionals. This study proposed a hypothetical model in which Areas of Worklife potentially contribute to Job Burnout/Engagement among construction professionals in Thailand and explored the consequential relationships between perceived Job Performance and Turnover Intentions. Cross-Sectional data was explored using an online questionnaire survey, and Structural Equation …

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Evaluation Of Root And Canal Morphology Of Mandibular First Permanent Molars In A Selected Thai Population Using Cone-Beam Computed Tomography, Pitcha Suwannasin Jan 2023

Evaluation Of Root And Canal Morphology Of Mandibular First Permanent Molars In A Selected Thai Population Using Cone-Beam Computed Tomography, Pitcha Suwannasin

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of current study was to investigate numbers of root canal, canal configurations, canal curvatures and pulp chamber of the mandibular first molars using cone-beam computed tomography (CBCT) images in a selected Thai population. Total of 492 mandibular first molars were evaluated. The number of roots, root canals and their root canal configurations were recorded. When c-shaped molars were excluded, 479 teeth were further investigated the number and direction of root canal curvature, also morphological of pulp chamber. Correlations with gender, tooth side and age (for pulp chamber) were analyzed. This current study found that the prevalence of teeth …

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Wear Resistance And Surface Roughness Of Injectable Resin Composites After Chewing Simulation, Napat Lapaschaone Jan 2023

Wear Resistance And Surface Roughness Of Injectable Resin Composites After Chewing Simulation, Napat Lapaschaone

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study was to evaluate wear resistance and surface roughness of injectable resin composites after undergoing chewing simulation and compared with those of conventional flowable resin composites and conventional paste resin composites. Ten specimens of each product from three different types: 1) two injectable resin composites (GU, BI), 2) two conventional flowable resin composites (SF, BF) and 3) two conventional paste resin composite (GP,BT), were fabricated in a sample holder and top surface was polished using silicon carbide papers. The surface topography of the specimens was profiled using three-dimensional contact profilometer before subjected to chewing simulation at …

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Fracture Strength Of Restored Tunnel Preparation With Various Heights Of Marginal Ridge, Phirinat Aurpanchasin Jan 2023

Fracture Strength Of Restored Tunnel Preparation With Various Heights Of Marginal Ridge, Phirinat Aurpanchasin

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to investigate fracture strength of restored tunnel preparation with different marginal ridge heights, using various adhesives and restorative materials. 130 intact premolars were randomly allocated into 13 groups based on 3 remaining marginal ridge heights (1.0, 2.0, and 3.0 mm) and 4 adhesive restorative techniques (Optibond™ FL, ER; selective enamel etching mode Single Bond Universal Adhesive, UA; Equia Forte Fil, HGI and positive control, PC) and negative control (NC). Tunnel preparation and restoration were performed. After 10,000 thermocycled, each specimen underwent fracture strength test until fractured, and evaluated for mode of failure. The data were evaluated using …

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The Expression Of Incretin Hormones And Their Receptors In The Submandibular Glands Of Offspring From High Fat Diet-Fed Mother Rats, Pornchanok Sangsuriyothai Jan 2023

The Expression Of Incretin Hormones And Their Receptors In The Submandibular Glands Of Offspring From High Fat Diet-Fed Mother Rats, Pornchanok Sangsuriyothai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Incretins, i.e., glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) promote insulin secretion to reduce postprandial blood sugar. Previous studies found incretins in the salivary glands in rat. However, the role of GLP-1 and GIP in the submandibular gland (SMG) is unclear. This study investigates the effects of a high-fat diet (HFD) on the expression of GLP-1 and GIP throughout the development of rat SMG. Pregnant 11-week-old rats were divided into standard diet and HFD groups (n = 5 each). The newborns were divided into four subgroups (n = 6): standard diet males, HFD males, standard diet females, and HFD …

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Silk Fibroin-Platelet Rich Plasma Injectable Hydrogel With Controlled-Release Of Growth Factors For Knee Osteoarthritis, Suvinai Jiraboonsri Jan 2023

Silk Fibroin-Platelet Rich Plasma Injectable Hydrogel With Controlled-Release Of Growth Factors For Knee Osteoarthritis, Suvinai Jiraboonsri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Currently, there is no treatment that can stop the progression of osteoarthritis (OA). Platelet Rich Plasma (PRP) is a promising therapy. However, significant challenges remain for the effective use of PRP in OA treatment, namely its burst-like release of growth factors and its short-acting time due to rapid synovial clearance. Silk fibroin is a safe biomaterial for drug delivery system. Therefore, in this study, Silk-Fibroin-Platelet-Rich Plasma injectable hydrogels with the ability to controllably release growth factors were developed and characterised. Two silk fibroin-platelet-rich-plasma (SF-PRP) hydrogel with silk fibroin concentrations of 1% w/v (1% SF-PRP) and 2% w/v (2% SF-PRP) were …

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Effects Of The Cutting Flute Characteristic Of The Orthodontic Miniscrew On Bone Microdamage And Primary Stability, Sansanee Wijarn Jan 2023

Effects Of The Cutting Flute Characteristic Of The Orthodontic Miniscrew On Bone Microdamage And Primary Stability, Sansanee Wijarn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Orthodontic miniscrews was developed as an anchorage. Cutting flute geometry of the screw is important for the stability; however, it has not been fully investigated. This study aim to evaluate the effect of cutting flute geometry on cortical bone microdamage and stability. Human bone analogs, 1.0 mm thick, were prepared alongside custom-made Ti6Al4V screws. These screws, with no flutes or modified flute geometries, came in lengths of 1.2, 2.4, and 5.0 mm, each with rake angles of 0° and 20°. Each screw was inserted into a bone sample and removed while measuring the maximum insertion torque and the maximum removal …

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Evaluation Of Tensile Bond Strength Of Various Denture Relining Materials To Conventional And Cad/Cam Manufactured Denture Base Polymers, Pilipda Janyaprasert Jan 2023

Evaluation Of Tensile Bond Strength Of Various Denture Relining Materials To Conventional And Cad/Cam Manufactured Denture Base Polymers, Pilipda Janyaprasert

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study was to investigate the tensile bond strength (TBS) of autopolymerized, heat-polymerized, milled, and 3D printed denture base materials bonded to 2 acrylic-based and 2 silicone-based denture liners, both before and after thermocycling. Four different denture base materials (Palapress (PL), Vertex Rapid Simplified (VR), Smile CAM total prosthesis (SC), and NextDent denture 3D+ (ND)) bonded to 2 acrylic-based (GC Soft-Liner (GC) and Tokuyama Rebase II (RB)) and 2 silicone-based (Ufi Gel P (UP) and Sofreliner Tough M (ST)) denture liners were tested. Specimens (n=8) were divided into non-thermocycling and thermocycling groups. Data were analyzed using 2-way ANOVA and Tukey …

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The Comparison Of Learning Outcome Of Dental Implant Placement Training In Esthetic Zone Using Dynamic Navigation System Between Novice Dentists And Experience Dentists, Hatsapon Teparrukkul Jan 2023

The Comparison Of Learning Outcome Of Dental Implant Placement Training In Esthetic Zone Using Dynamic Navigation System Between Novice Dentists And Experience Dentists, Hatsapon Teparrukkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: The increasing importance of CAIS in the practice of implant dentistry calls for adequate education and training of clinicians, however little evidence is available to support educational strategies and best practice. Purpose: The aim of this study was to investigate the effectiveness of distributed training with d-CAIS in the accuracy of freehand implant placement by inexperienced operators. Materials and Methods: Six senior dental students without experience in implant placement and dynamic CAIS systems​ received simulation in free-hand implant surgery (5 implants), followed by distributed training in dynamic CAIS (6 implants). An assessment followed in freehand implant placement (5 implants). …

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Autogenous Raw Tooth Particles Versus Xenograft For Alveolar Ridge Preservation: A Prospective Controlled Clinical Trial, Basel Mahardawi Jan 2023

Autogenous Raw Tooth Particles Versus Xenograft For Alveolar Ridge Preservation: A Prospective Controlled Clinical Trial, Basel Mahardawi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: The use of extracted teeth has been recently introduced as an option for bone grafting. However, the current method requires special machines and solutions, which poses significant time and cost. The aim of this study was to evaluate the clinical performance of autogenous Raw Tooth Particles (RTP), a grafting material made from a ground tooth using basic equipment, for alveolar ridge preservation. Materials and methods: 14 and 13 sites (23 patients) were included for the study and control group, respectively. The control group received Bio-Oss® xenograft. Radiographic measurements (in millimeters) were taken at the baseline and at the 4-month …

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Oral And Dental Prostheses Status In Mild And Moderate Dementia Patients, Tunyatorn Ratanawatanasin Jan 2023

Oral And Dental Prostheses Status In Mild And Moderate Dementia Patients, Tunyatorn Ratanawatanasin

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study focused on understanding the oral health and dental prostheses status of patients with mild to moderate dementia at King Chulalongkorn Memorial Hospital. A total of 88 patients participated in this cross-sectional study, which utilized the Oral Health Assessment Tool (OHAT) and modified CDA score to evaluate the oral health of patients with a dementia diagnosis. The study revealed significant oral health issues among participants, particularly in terms of gum and oral tissue problems, and oral cleanliness. Although 45.5% of participants had at least 20 functional teeth, a high prevalence of dental decay was observed. Many of the fixed …

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Comparison Of The Accuracy Of Implant Placement Between Using Sleeve-In-Sleeve And Integrated Sleeve-On-Drill Drilling Systems For Static Computer-Assisted Implant Surgery: A Simulation-Based Experimental Study, Papon Pattanasirikun Jan 2023

Comparison Of The Accuracy Of Implant Placement Between Using Sleeve-In-Sleeve And Integrated Sleeve-On-Drill Drilling Systems For Static Computer-Assisted Implant Surgery: A Simulation-Based Experimental Study, Papon Pattanasirikun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: To investigate precision of implant placement with sleeve-in-sleeve and sleeve-on-drill static Computer Assisted Implant Surgery (sCAIS) designs. Materials and Methods: 32 models were digitally planned and fabricated simulating a patient with bilateral missing first premolar. 8 models were assigned in each group: Group A, B and C represented sleeve-in-sleeve design with 2, 4 and 6mm sleeve height respectively. Group D represented integrated sleeve-on-drill design with 4 mm sleeve height. All models were scanned with CBCT and desktop optical scanner. 16 implants were planned and placed using sCAIS for each group. 3D deviation of placed and planned position at implant …

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การเปลี่ยนแปลงคุณภาพชีวิตในมิติสุขภาพช่องปากและในมิติสุขภาพในผู้ป่วยที่ได้รับการรักษาทางทันตกรรมประดิษฐ์, ปิยอนงค์ วรรณขาว Jan 2023

การเปลี่ยนแปลงคุณภาพชีวิตในมิติสุขภาพช่องปากและในมิติสุขภาพในผู้ป่วยที่ได้รับการรักษาทางทันตกรรมประดิษฐ์, ปิยอนงค์ วรรณขาว

Chulalongkorn University Theses and Dissertations (Chula ETD)

การศึกษานี้เป็นการศึกษาไปข้างหน้าจากเหตุไปหาผลในผู้ป่วยเข้ารับการรักษารับการรักษาทางทันตกรรรมประดิษฐ์จำนวน 87 คน ผลลัพธ์ของการศึกษาคือคุณภาพชีวิตในมิติสุขภาพช่องปากและคุณภาพชีวิตในมิติสุขภาพ โดยใช้ดัชนีประเมินผลกระทบของสุขภาพช่องปากต่อสมรรถภาพในชีวิตประจำวันและเครื่องมือวัดคุณภาพชีวิตขององค์การอนามัยโลกฉบับย่อ ตามลำดับ ตัวแปรร่วม ได้แก่ ลักษณะทั่วไป สภาวะสุขภาพและสภาวะสุขภาพช่องปาก เก็บข้อมูลโดยการสัมภาษณ์ การตรวจในช่องปากและการศึกษาจากแฟ้มประวัติ หลังการแก้ไขฟันเทียมครั้งสุดท้าย 1 เดือน เก็บข้อมูลคุณภาพชีวิตในมิติสุขภาพช่องปากและคุณภาพชีวิตในมิติสุขภาพโดยการสัมภาษณ์ทางโทรศัพท์ ใช้การทดสอบของการทดสอบวิลคอกซันวิเคราะห์การเปลี่ยนแปลงของคะเเนน OIDP และ WHOQOL-BREF เวลาก่อนและหลังการรักษา ข้อมูลทั้งหมดวิเคราะห์ที่ระดับนัยสำคัญร้อยละ 5 ผลการศึกษาแสดงว่าหลังการรักษาผู้เข้าร่วมการศึกษามีคะแนน OIDP รวมลดลงอย่างมีนัยสำคัญทางสถิติ และคะแนน WHOQOL-BREF รวมเพิ่มขึ้นอย่างมีนัยสำคัญทางสถิติ โดยที่เวลาก่อนการรักษาปัจจัยที่ส่งผลต่อคะแนน OIDP รวมคือจำนวนฟันธรรมชาติและจำนวนคู่สบฟันหลัง ในขณะที่ปัจจัยที่ส่งผลต่อคะแนน WHOQOL-BREF รวมคือสถานภาพสมรสและความเพียงพอของรายได้ จึงสรุปได้ว่าภายหลังการรักษาทางทันตกรรมประดิษฐ์ผู้ป่วยมีคุณภาพชีวิตในมิติสุขภาพช่องปากและคุณภาพชีวิตในมิติสุขภาพดีขึ้น

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Improving Player Skills In Action Games Using Dynamic Scripting Ai, Pakanan Aimherungilas Jan 2023

Improving Player Skills In Action Games Using Dynamic Scripting Ai, Pakanan Aimherungilas

Chulalongkorn University Theses and Dissertations (Chula ETD)

Complexity in video games is one of the obstacles that prevent new players from enjoying the game. In an action game genre, players require a certain level of reaction time and game knowledge to overcome a challenge. Players have difficulty learning and improving their skills in complex games. One example being Final Fantasy VIII and its tutorial about magic junction system, the main mechanic of the game that the game quickly explained with numerous texts. Due to its complexity, most players could not understand the mechanic properly, leaving them confused and having a hard time playing the game. Players who …

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Utilization Of Plasma Technology For De-Inking And Hydrogenation Without Catalyst, Ika Priyanti Jan 2023

Utilization Of Plasma Technology For De-Inking And Hydrogenation Without Catalyst, Ika Priyanti

Chulalongkorn University Theses and Dissertations (Chula ETD)

Catalyst-free plasma technologies have been successfully utilized for de-inked and hydrogenated processes. These green methods have nonchemical contributions, operating at room temperature and atmospheric pressure, reducing the environmental impact of the process. Two plasma types and arrangements were studied in this research: corona plasma (de-inking) and dielectric barrier discharge plasma (hydrogenation). The results found that the deinkability factors were 48.58% (yellow printed paper), 64.11% (blue printed paper), and 41.11% (red printed paper) without altering the physical properties of the paper itself. The change in the tensile strength for the plasma-exposed paper was relatively little, less than 10%, compared to that …

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Removal Of Perfluorooctanoic Acid (Pfoa) In Water With Dbd-Plasma-Enhanced Adsorbent, Thera Sahara Jan 2023

Removal Of Perfluorooctanoic Acid (Pfoa) In Water With Dbd-Plasma-Enhanced Adsorbent, Thera Sahara

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study examined the enhancement of PFOA removal from water using DBD plasma-modified adsorbents, specifically rice husks (RHs) and granular activated carbon (GAC). RHs treated with He-O2 plasma after phosphoric acid activation demonstrated a significant increase in adsorption efficiency, improving from 46.4% to 92.0% under optimal conditions. Adjusting pH to 4 further increased efficiency to 96.7%. The adsorption process followed the Langmuir model and pseudo-second-order kinetics, with a maximum capacity of 565 mg/g. The effects of DBD plasma on GAC in the presence of natural organic matter (NOM) were also assessed. Optimal plasma treatment enhanced PFOA removal in both deionized …

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Virtual Reality Of Labless Foundry And Heat Treatment For Next Industrial Training, Naris Lawankowit Jan 2023

Virtual Reality Of Labless Foundry And Heat Treatment For Next Industrial Training, Naris Lawankowit

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study presents an innovative Virtual Reality (VR) application tailored to educate users on Foundry and Heat Treatment operations. Its primary objectives encompass the creation of a secure and lifelike learning environment while ensuring accessibility. The development process was a meticulous fusion of technology, incorporating the Unity engine, 3D modeling, and seamless Salesforce integration, all grounded in extensive research. The VR application's structure strategically subdivides these industrial processes into four stations: Molding, Furnace, Workbench, and Heat Treatment. This detailed approach empowers users to engage directly in these operations, making it a valuable educational tool. The study's significance extends to the …

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การออกแบบระบบแชทบอทร่วมกับปัญญาประดิษฐ์ช่วยวินิจฉัยการแพ้ยา, ปกรณ์ เสงี่ยมรัตน์ Jan 2023

การออกแบบระบบแชทบอทร่วมกับปัญญาประดิษฐ์ช่วยวินิจฉัยการแพ้ยา, ปกรณ์ เสงี่ยมรัตน์

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยนี้มุ่งเน้นการศึกษาและพัฒนาระบบปัญญาประดิษฐ์เพื่อช่วยวินิจฉัยอาการแพ้ยา โดยใช้ระบบแชทบอทปัญญาประดิษฐ์ที่มีการประมวลผลภาษาธรรมชาติ (NLP) และเทคนิคการจำแนกประเภทข้อมูลภาพ ในการวิจัยและพัฒนาแบบจำลองการจำแนกข้อมูลภาพเพื่อการตรวจหาอาการแพ้ยา นักพัฒนาเลือกใช้แบบจำลอง InceptionV3 และแบบจำลอง MobileNetV2 ซึ่งเป็นโครงข่ายประสาทเทียมแบบคอนโวลูชัน ผลการศึกษาชี้ให้เห็นว่าแบบจำลอง MobileNetV2 มีประสิทธิภาพดีกว่าแบบจำลอง InceptionV3 โดยมีความแม่นยำสุดท้ายที่ 99.29% อีกทั้งขนาดของแบบจำลอง MobileNetV2 มีขนาดเล็กทำให้เหมาะสำหรับการใช้งานบนสมาร์ทโฟนและยังพบว่าการจำแนกผื่นแพ้ยาสามารถทำได้อย่างมีประสิทธิภาพ และเมื่อนำแบบจำลองไปมาใช้ในแชทบอทที่พัฒนา พบว่าแบบจำลองที่มีค่า Kappa 0.76 มีความเห็นพ้องที่ดีระหว่างการทำนายและค่าจริง ส่วนการทดสอบการพัฒนาและการใช้งานของแชทบอทประสบให้ผลลัพธ์ที่เป็นบวก แชทบอทสามารถตอบสนองสถานการณ์ที่อาสาสมัครทดสอบได้ 100% และมีคะแนน System Usability Scale (SUS) ที่ยอมรับได้ที่ 70.1 ด้วยการพัฒนานี้ทำให้ผู้ป่วยที่มีอาการแพ้ยาชนิดไม่รุนแรง ไม่จำเป็นต้องเดินทางไปโรงพยาบาล ระบบแชทบอทสามารถช่วยเหลือเบื้องต้นในการวิเคราะห์อาการแพ้ยา ข้อมูลชนิดการแพ้ยา ข้อมูลบริการคลินิก และให้คำแนะนำเพื่อลดอาการไม่พึงประสงค์ ซึ่งยังช่วยลดเวลาเดินทางและค่าใช้จ่ายที่เกี่ยวข้องกับการไปโรงพยาบาล นอกจากนี้ระบบแชทบอทที่ได้พัฒนาขึ้นมานี้ยังสามารถเป็นต้นแบบเพื่อสนับสนุนความก้าวหน้าของเทคโนโลยีการแพทย์ในอนาคตและการรองรับเข้าสู่ยุคปัญญาประดิษฐ์

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Hydrophobic Deep Eutectic Solvent-Based Ferrofluid For Removal Of Parabens, Aswin Falahudin Jan 2023

Hydrophobic Deep Eutectic Solvent-Based Ferrofluid For Removal Of Parabens, Aswin Falahudin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hydrophobic deep eutectic solvent-based ferrofluids were prepared by combining magnetic nanocomposites and hydrophobic deep eutectic solvent, and studies for paraben removal were conducted. The final products were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, surface area analyzer, scanning electron microscopy, thermogravimetric analysis, vibrating sample magnetometer, and UV-Vis spectrophotometer. SEM images and XRD pattern showed that the magnetic nanocomposite particles are mostly spherical and the magnetite phase of iron oxide and amorphous silica. The surface area of these materials ranged from 97.02 m2/g for the bare magnetite to 132.80 m2/g, 292.74 m2/g, and 421.88 m2/g after modified with silica shell …

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Design, Synthesis, And Biological Evaluation Of Darunavir Analogs As Hiv-1 Protease Inhibitors, Muhammad Asad Ur Rehman Jan 2023

Design, Synthesis, And Biological Evaluation Of Darunavir Analogs As Hiv-1 Protease Inhibitors, Muhammad Asad Ur Rehman

Chulalongkorn University Theses and Dissertations (Chula ETD)

Darunavir, a potent inhibitor for HIV protease (PR) for the treatment of HIV infection, encounters limitations due to the emergence of multi-drug resistance HIV strains, imposing the development of darunavir analogs as new HIV protease inhibitors (PI) with enhanced efficacy. In this study, a combinatorial in silico method was used to at first design a several HIV-1 PI analogs with variations at key sites, P1' and P2', to improve the interactions with HIV-1 PR. Fifteen analogs with encouraging binding score were selected for synthesis and assessed for the inhibition activity of HIV-1 PR. The study demonstrated the effectiveness of P2' …

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Label-Free Electrochemical Immunosensor For Simultaneous Detection Of Norfloxacin And Enrofloxacin, Kittima Chomthong Jan 2023

Label-Free Electrochemical Immunosensor For Simultaneous Detection Of Norfloxacin And Enrofloxacin, Kittima Chomthong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Electrochemical immunosensors for the simultaneous detection of antibiotics have been of interest and have been reported previously. However, those methods still require difficult labeling for the reporting of electrochemical signals. This research aimed to develop a novel label-free electrochemical immunosensor with an origami paper-based analytical device (oPAD) for the simultaneous detection of quinolone antibiotics. Norfloxacin (Nor) and Enrofloxacin (Enr) are among the quinolone antibiotics, and they are used as models to study antibiotic detection. Nor and Enr antibodies were immobilized separately onto the functionalized oPAD. Thionine and ferrocenecarboxylic acid were coated onto the redox species area to detect Nor and …

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Development Of Hamper Pad On Lateral Flow Immunoassay For Sensitivity Improvement Of Carbendazim Detection, Pumnatthiga Makkala Jan 2023

Development Of Hamper Pad On Lateral Flow Immunoassay For Sensitivity Improvement Of Carbendazim Detection, Pumnatthiga Makkala

Chulalongkorn University Theses and Dissertations (Chula ETD)

Carbendazim (CBZ) is a fungicide that effectively controls fungal diseases like sheath blight, leaf spot, powdery mildew, and pythium root rot in agricultural products. However, CBZ can be a left residue in food and the environment that can affect human health and cause various diseases. Currently, lateral flow immunoassays (LFIAs) are commonly used for measuring and screening diseases or substances; they are low-cost and easily portable. Nevertheless, conventional LFIA methods have a drawback: low detection sensitivity. Structural improvement of LFIAs has been studied to enhance detection sensitivity. In this study, a hamper pad was fabricated using a nitrocellulose membrane coated …

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Risk Assessment Of Leached Heavy Metals From End-Of-Life Thin Film Solar Photovoltaics, Pornnapat Ruengrit Jan 2023

Risk Assessment Of Leached Heavy Metals From End-Of-Life Thin Film Solar Photovoltaics, Pornnapat Ruengrit

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study investigated the risk of heavy metal leaching from end-of-life thin film solar photovoltaic (PV) panels, commonly disposed of in landfills, potentially contaminating groundwater. Various heavy metals including Al, Ag, Cd, Cu, Cr, Fe, Ga, In, Mo, Ni, Pb, Se, Te, As, Mn, and Zn were studied for leaching using standard methods such as TCLP and SPLP. The research compared the efficacy of these methods and examined the announcement of the Ministry of Industry regarding the disposal of waste or unused materials, B.E. 2023. Aging processes were applied to thin film PV samples including a-Si, CIGS, and CdTe. The …

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Adsorption Behavior Of Air-Pollution Gases On Boron Nitride Nanotubes For Gas Sensing And Storage, Viny Alfiyah Jan 2023

Adsorption Behavior Of Air-Pollution Gases On Boron Nitride Nanotubes For Gas Sensing And Storage, Viny Alfiyah

Chulalongkorn University Theses and Dissertations (Chula ETD)

Structures of pristine (5,5) and (10,0) BNNTs, their Al-, Ga-, Cr- and Fe-doping derivatives, and their adsorption structures with H2O, H2S, SO2, CO2, CO, NH3, N2O, and NO were explored using periodic DFT/PBEPBE/ method. N2O and SO2 adsorbed either on the Cr-(5,5) or Cr-(10,0) BNNT were found to be the strongest and the second-strongest adsorptions, respectively. N2O adsorption either on the Cr-(5,5) or Cr-(10,0) BNNT found as dissociative chemisorption is suggested as the catalyst for reductive conversion of N2O to N2 and O2 gases, of which overall reaction of -0.253 eV was found. Cr-(5,5) and Cr-(10,0) BNNTs are suggested as …

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Antioxidant And Anticancer Activities Of Polysaccharide Extracted From White-Rot Fungus Trametes Polyzona Cu07, Budi Kurniawan Jan 2023

Antioxidant And Anticancer Activities Of Polysaccharide Extracted From White-Rot Fungus Trametes Polyzona Cu07, Budi Kurniawan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Over the last decade, fungal polysaccharides have gained interest for their therapeutic activity as anticancer agent. This research aimed to investigate a newly isolated Trametes polyzona CU07 for its anticancer and antioxidant activity. CTPPs, an obtained crude polysaccharides of T. polyzona were extracted by hot water from its mycelia. Subsequently, the extract was analysed its chemical properties. Scavenging activity on ABTS and DPPH was evaluated for antioxidant performance. Furthermore, the anticancer activity was evaluated by performing the inhibitory effects, proliferation, apoptosis induction and colony formation assay. MCF-7 cell line and triple negative breast cancer (MDA-MB-231 and MDA-MB-468) were used as …

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Phytochemical Of Dioscorea Bulbifera For Cosmeceuticals, Shabnam Pari Jan 2023

Phytochemical Of Dioscorea Bulbifera For Cosmeceuticals, Shabnam Pari

Chulalongkorn University Theses and Dissertations (Chula ETD)

People across various cultures have utilized plant-based substances to enhance their appearance, and cosmetics with active agents to lighten skin tone has been used. Skin whitening practices typically involve chemical constituents designed to reduce melanin and oxidative stress. People worldwide prefer using natural products to enhance their appearance due to its safety and less side effects. The intake of plant-derived bioactive agents has become increasingly popular due to their health benefits. Different forms of plants contain varying quantity of bioactive compounds. For example, drying, a common method of food preparation, significantly impacts the quantity of these compounds. Fresh and dried …

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Development Of Antioxidant From Spent Coffee Ground And Its Appication, Chitinsee Paidech Jan 2023

Development Of Antioxidant From Spent Coffee Ground And Its Appication, Chitinsee Paidech

Chulalongkorn University Theses and Dissertations (Chula ETD)

Spent coffee grounds (SCG) are a by-product from coffee brewing process. SCG contains a considerable amount of organic compounds and is a great source of antioxidants. This research aimed to evaluate the antioxidant activities of SCG and SCG extracts by comparing different solvent (hexane and 60 - 90% ethanol) extractions, together with determining the effect of different concentration (5, 10, 15, 20 and 25%) of SCG extracts (SCG) and comparing these extracts with commercial antioxidants (BHA (A), BHT (T), tocopherol (TO)) for application to vegetable oil. The results showed that the total phenolic content (TPC) of SCG was 16.49 mg …

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อิทธิพลของความเค็มต่อไมโครไบโอต้าและการแสดงออกของยีนที่เกี่ยวข้องกับกรดไขมันไม่อิ่มตัวเชิงซ้อนของโคพีพอด Apocyclops Royi, ณัฐกนกพร ประยูรมณีรัตน์ Jan 2023

อิทธิพลของความเค็มต่อไมโครไบโอต้าและการแสดงออกของยีนที่เกี่ยวข้องกับกรดไขมันไม่อิ่มตัวเชิงซ้อนของโคพีพอด Apocyclops Royi, ณัฐกนกพร ประยูรมณีรัตน์

Chulalongkorn University Theses and Dissertations (Chula ETD)

โคพีพอด Apocyclops royi เป็นแพลงก์ตอนสัตว์ในกลุ่มครัสเตเชียนที่มีบทบาทสำคัญต่อการอนุบาลสัตว์น้ำวัยอ่อนเนื่องจากมีคุณค่าทางโภชนาการที่โดดเด่นและสามารถสังเคราะห์กรดไขมันสายยาวไม่อิ่มตัวเชิงซ้อน (LC-PUFA) ในงานวิจัยนี้ได้ศึกษาหน้าที่และการแสดงออกของยีน Fatty acid-binding protein (FABP) ซึ่งเป็นโปรตีนที่มีหน้าที่สำคัญในการขนส่งกรดไขมัน ผลจากการศึกษาลักษณะสมบัติของยีน ArFABP ของโคพีพอดสายพันธุ์ไทย A. royi-TH พบว่าประกอบด้วยบริเวณ open reading frame จำนวน 465 คู่เบส ซึ่งสามารถแปลรหัสเป็นโปรตีนขนาด 154 กรดอะมิโน โดยโปรตีน ArFABP ประกอบด้วยบริเวณ Lipocalin_7 domain ซึ่งมีความเหมือนกับโปรตีน FABP ในโคพีพอด Caligus rogercresseyi 55% จากการศึกษาหน้าที่ของยีน ArFABP ต่อความเกี่ยวข้องในการสังเคราะห์กรดไขมัน PUFA ในโคพีพอด ได้ทำการตรวจสอบการแสดงออกของยีน ArFABP ในตัวอย่างโคพีพอด A. royi-TH กลุ่มที่เลี้ยงด้วย Tetraselmis sp. (TET) เปรียบเทียบกับ Thalassiosira sp. (THA) พบว่าโคพีพอดกลุ่มที่เลี้ยงด้วย THA มีระดับการแสดงออกของยีน ArFABP สูงกว่าโคพีพอดกลุ่มที่เลี้ยงด้วย TET อย่างมีนัยสำคัญทางสถิติ ซึ่งสอดคล้องกับผลการวิเคราะห์องค์ประกอบของกรดไขมัน พบว่าโคพีพอดกลุ่มที่เลี้ยงด้วย THA มีสัดส่วนของกรดไขมัน LC-PUFA และกรดไขมัน arachidonic acid (ARA) สูงกว่ากลุ่มที่เลี้ยงด้วย TET อย่างมีนัยสำคัญทางสถิติ นอกจากนี้ผลจากงานวิจัยยังพบว่าระดับการแสดงออกของยีน ArFABP มีการแสดงออกสูงในโคพีพอดที่เลี้ยงในสภาวะความเค็ม 15 พีพีที (ความเค็มต่ำ) เปรียบเทียบกับกลุ่มโคพีพอดที่เลี้ยงในสภาวะความเค็ม 25 พีพีที (กลุ่มควบคุม) โดยพบว่าโคพีพอดกลุ่มความเค็ม 15 พีพีที มีสัดส่วนของกรดไขมัน ARA สูงกว่ากลุ่มความเค็ม 25 พีพีที อย่างมีนัยสำคัญทางสถิติ โดยจากผลการศึกษานี้แสดงให้เห็นว่ายีน ArFABP อาจมีบทบาทเกี่ยวข้องกับการขนส่งกรดไขมันในการสังเคราะห์กรดไขมัน LC-PUFA ในโคพีพอด และจากการศึกษาไมโครไบโอมพบว่าการเพาะเลี้ยงโคพีพอด A. …

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Electrochemical Dna Super-Sandwich Biosensor For Porcine Dna Adulteration Detection In Foods, Vasita Lapeee Jan 2023

Electrochemical Dna Super-Sandwich Biosensor For Porcine Dna Adulteration Detection In Foods, Vasita Lapeee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Amid increasing concerns over meat adulteration and mislabeling, which impact consumer trust, especially among people who are forbidden from consuming certain meats due to religious, cultural, and health reasons, there is a need for reliable detection methods. Although standard methods for genetic material detection, such as DNA amplification, offer high sensitivity, they also present limitations in terms of cost, instrument complexity, and lengthy detection times. Addressing these limitations, this thesis focuses on developing an electrochemical DNA sensor for detecting porcine DNA contamination in food without prior DNA amplification. The proposed method is straightforward, rapid, and cost-effective. The detection process involves …

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Volatile Compound Profiles In Human Sweat Before And After Covid-19 Vaccination, Sorachar Phusrisom Jan 2023

Volatile Compound Profiles In Human Sweat Before And After Covid-19 Vaccination, Sorachar Phusrisom

Chulalongkorn University Theses and Dissertations (Chula ETD)

Vaccines have been reported to be effective at preventing people from getting the coronavirus (COVID-19) as well as reducing the harmful levels. This led to incorporation of the vaccinations into the protection protocol worldwide. The vaccinations could influence metabolisms, microbiome and metabolite distribution throughout human bodies including skin. This thesis applied gas chromatography ion mobility spectrometry (GC-IMS) and gas chromatography mass spectrometry (GC-MS) to differentiate the population with COVID-19 vaccination based on their different sweat volatile compound profiles. This involves tentative identification of 160 axillary swab samples obtained from 20 healthy volunteers before or after the COVID-19 vaccination at different …

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