Digital Commons Network^™

Two Phase 3 Trials Of Gantenerumab In Early Alzheimer's Disease, Randall J Bateman, Et Al.

2020-Current year OA Pubs

BACKGROUND: Monoclonal antibodies that target amyloid-beta (Aβ) have the potential to slow cognitive and functional decline in persons with early Alzheimer's disease. Gantenerumab is a subcutaneously administered, fully human, anti-Aβ IgG1 monoclonal antibody with highest affinity for aggregated Aβ that has been tested for the treatment of Alzheimer's disease.

METHODS: We conducted two phase 3 trials (GRADUATE I and II) involving participants 50 to 90 years of age with mild cognitive impairment or mild dementia due to Alzheimer's disease and evidence of amyloid plaques on positron-emission tomography (PET) or cerebrospinal fluid (CSF) testing. Participants were randomly assigned to receive gantenerumab …

Identification Of Cdk1, Pbk, And Chek1 As An Oncogenic Signature In Glioblastoma: A Bioinformatics Approach To Repurpose Dapagliflozin As A Therapeutic Agent, Alexander T H Wu

Faculty, Staff and Student Publications

Glioblastoma multiforme (GBM) is the most aggressive and lethal primary brain tumor whose median survival is less than 15 months. The current treatment regimen comprising surgical resectioning, chemotherapy with Temozolomide (TMZ), and adjuvant radiotherapy does not achieve total patient cure. Stem cells' presence and GBM tumor heterogeneity increase their resistance to TMZ, hence the poor overall survival of patients. A dysregulated cell cycle in glioblastoma enhances the rapid progression of GBM by evading senescence or apoptosis through an over-expression of cyclin-dependent kinases and other protein kinases that are the cell cycle's main regulatory proteins. Herein, we identified and validated the …

Tami Spry: The Force Of (Co-)Performing, Ken Gale, Jonathan Wyatt

Plymouth Institute of Education

In this short article, we work with the notion of Tami Spry as force. There is a tension here: We have come to recognize, both through the writing of this article and through our many years of encountering both Tami herself and Tami’s work as performer and writer, how we find ourselves needing to de-personalize and de-individualize: we are drawn into the beyond, the uncontainable, the “more-than,” of Tami and Tami’s work. At the same time as this impulse to de-personalize and de-individualize, we recognize—and cherish—that Tami Spry’s work could not happen without Tami Spry. We experience, and seek to …

Candida Auris-Macrophage Cellular Interactions And Transcriptional Response

Faculty, Staff and Student Publications

The pathogenic yeast Candida auris represents a global threat of the utmost clinical relevance. This emerging fungal species is remarkable in its resistance to commonly used antifungal agents and its persistence in the nosocomial settings. The innate immune system is one the first lines of defense preventing the dissemination of pathogens in the host. C. auris is susceptible to circulating phagocytes, and understanding the molecular details of these interactions may suggest routes to improved therapies. In this work, we examined the interactions of this yeast with macrophages. We found that macrophages avidly phagocytose C. auris; however, intracellular replication is …

Endoscopic Retrograde Cholangiopancreatography-Related Early Perforations: A Study Of Effects Of Procedure Duration, Complexity, And Endoscopist Experience, Ghassan M Hammoud, Ganesh Aswath, Vaibhav Wadhwa, Nirav Thosani

Faculty, Staff and Student Publications

BACKGROUND: Perforations (Perf) during endoscopic retrograde cholangiopancreatography (ERCP) are rare (< 1%) but potentially fatal events (up to 20% mortality). Given its rarity, most data is through case series studies from centers or analysis of large databases. Although a meta-analysis has shown fewer adverse events as a composite (bleeding, pancreatitis, Perf) during ERCP performed at high-volume centers, there is very little real-world data on endoscopist and center procedural volumes, ERCP duration and complexity on the occurrence of Perf.

AIM: To study the profile of Perf related to ERCP by center and endoscopist procedure volume, ERCP time, and complexity from a national endoscopic repository.

METHODS: Patients from clinical outcomes research initiative-national endoscopic database (2000-2012) who underwent ERCP were stratified based on the endoscopist and center volume (quartiles), and total procedure duration and complexity grade of the ERCP based on procedure details. The effects of these variables on the Perf that occurred were studied. Continuous variables were compared between Perf and no perforations (NoPerf) using the Mann-Whitney U test …

Internet Analytics Of An Innovative Digital Educational Resource Of Type 1 Diabetes Hellotype1 In Local Languages For People Living With Diabetes Families And Healthcare Professionals In Southeast Asia, Yang Xian Lucas Lim, Azriyanti Anuar Zaini, Taninee Sahakitrungruang, Anne Charlotte Ficheroulle

Faculty, Staff and Student Publications

BACKGROUND: There is minimal data of health outcomes for Type 1 Diabetes (T1D) in Southeast Asia (SEA) where government funding of insulin and blood glucose monitoring either do not exist or is limited. The full impact of Covid-19 pandemic on the national economies of SEA remain unknown. In the midst of the pandemic, in 2021, HelloType1 was developed by Action4Diabetes (A4D), a non-government organisation charity in collaboration with Southeast Asia local healthcare professionals as an innovative digital educational resource platform of T1D in local languages. HelloType1 was launched in Cambodia, Vietnam, Thailand and Malaysia in 2021 to 2022 with Memorandums …

Wagon Tracks Volume 38, Issue 1 (Nov 2023)

Wagon Tracks

Contents

2 On the Cover: The View from Wagon Mound: Jackie Fleming

4 Trail Writings: Chris Day

5 Joanne’s Jottings

6 News along the Trail

7-11 Tributes to Marc Simmons

12-13 The Caches: Joanne VanCoevern and Leo Oliva

14 SFTA Awards

15-20 Santa Fe Trail Association Hall of Fame

21-27 Hell on Wheels: El Moro,Trinidad, and Oteroby Dr. Michael L. Olsen

27 SFTA Action Items

28 Chapter Reports

29 Membership Form

32 Calendar

The Influence Of Race In Americans’ Trust Of Government, David B. Gomez

Compass: An Undergraduate Journal of American Political Ideas

The percentage of Americans who trust the government in Washington always or most of the time has been increasingly declining since the John F. Kennedy presidency in the early 1960s The reasons for this sharp downward bend are unclear. Americans do worry about political disagreement, which they see as an indication of an anomaly in the system. However, given the choice, they would rather concern themselves about nonpolitical issues. That factor has not stopped them from failing to trust their government. The expectations placed by Americans on their administration are excessively high. Thus, disappointment is inevitable. The declining trust exhibited …

Defense Industrial Base Assessment: United States Space Industry, Space And Defense

Space and Defense

Final Report Summary, August 2007

This report focuses on the health and competitiveness of the United States (U.S.) Space Industrial Base, including the associated impacts of U.S. export controls. The Department of Defense, through the Under Secretary of the Air Force and the Space Industrial Base Council directed this study. An Air Force Research Laboratory, Materials and Manufacturing Directorate representative led an industry government team and integrated the information gathered to prepare the study. The Department of Commerce’s Bureau of Industry and Security developed and deployed the survey instrument and verified data provided by companies comprising the U.S. Space Industry. …

The History Of United States Weapons Export Control Policy, Taylor Dinerman

Space and Defense

All nations regulate Arms sales, but the United States (U.S.) has traditionally gone further than most. After World War I, a conspiracy theory made its way into popular culture that blamed the war, and specifically the U.S. intervention in 1917, on the so called “merchants of death.” Ever since, this has been a powerful and enduring theme in politics and culture throughout the world. Yet, nowhere have the effects of this theory been more enduring than in U.S. policy and law.

Establishing Space Security: A Prescription For A Rules-Based Approach, Theresa Hitchens, Michael Katz-Hyman

Space and Defense

The question of what constitutes the proper military uses of space is not just a debate over space weapons and attacks on satellites. It is a debate that sheds light on the fundamental decisions that states and their citizens will have to make over the next century as we both explore and exploit space for its scientific, strategic, and economic value. Furthermore, the context of this debate changes year to year as the physical and political environment of space changes.

Vol. 58 No. 4 - Whole No. 399, Megan Abrahamson

Mythprint

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 58 No. 2 - Whole No. 397, Megan Abrahamson

Mythprint

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Exploring The Experiences Of Adjunct Clinical Dental Hygiene Faculty With Peer Mentorship As They Transition From Clinician To Educator, Rosalie Forrester

Doctor of Education Program Dissertations

The work-role transition from clinician to educator involves the dental hygienist creating a new identity as a dental hygiene educator. Insider guidance through peer mentorship may help support and acclimate new faculty during this work-role transition. The purpose of this qualitative narrative inquiry was to explore the experiences of adjunct clinical dental hygiene faculty with peer mentorship as they transitioned from the role of clinician to educator. Five participants who met the criteria for this study completed semi-structured, virtual interviews via Zoom. These interviews were restoried into narratives, categorized, and then manually coded into themes. The categories included development of …

Viewpoint: Space Law And The Advancement Of Spacepower, Peter L. Hays

Space and Defense

The opinions, conclusions, and recommendations expressed or implied in this paper are those of the author and do not necessarily reflect the official policy or position of the United States Air Force, Department of Defense, or United States Government. The author thanks David Koplow, Phil Meek, and Michael Saretsky for their extremely helpful comments on previous versions of this article.

Space law has and should continue to play an essential role in the evolution of spacepower. Testing the principle of “freedom of space” and helping establish the legality of satellite overflight were primary objectives of NSC- 5520, the first U.S. …

Viewpoint: Outer Space Treaty And Enhancing Space Security, Joanne Irene Gabrynowicz

Space and Defense

This article is republished here with permission from the author. See “Building the Architecture for Sustainable Space Security,” Conference Report, 30-31 March 2006, United Nations Institute for Disarmament Research.

The specific question addressed here is: what progress could be made at a possible Outer Space Treaty (OST) Revision Conference and how should a possible Revision Conference unfold?”1 The answer to the question as framed is, with serious trepidation and extreme caution. However, the question contains the assumption that a revision conference for the Treaty on Principles Governing the Activities of States in the Exploration and Use of Outer Space, including …

Air Force Space Command Perspective On Space Deterrence, Mike Manor, Kurt Neuman

Space and Defense

The Eisenhower Center for Space and Defense Studies embarked on an ambitious project when they tackled the subject of space deterrence. The end result is a comprehensive report that provides an excellent summary of changes in the strategic space environment, as well as a perceptive analytical framework for assessing deterrence options. The layered strategy – International Norms, Entanglement, Retaliation, and Denial – is an original model that nicely captures vital aspects of space deterrence. Closing out the report are recommendations that are practical and cogent, offering clear steps for improving the deterrent posture of the United States in space.

Space And Sino-American Security Relations, Peter L. Hays

Space and Defense

China’s emphasis on space exploration and its development and use of space capabilities are prominent and tangible expressions of its emergence as a great power and make space an increasingly important dimension of Sino-American relations. In October 2003 China independently launched and recovered its first taikonaut, becoming just the third member of an elite spacefaring club with Russia and the United States. Then in January 2007 China first successfully tested a kinetic energy anti-satellite (ASAT) weapon and again joined Russia and the United States as one of only three states known to have demonstrated this capability. China’s growing power and …

Speech For The 2008 National Space Forum, Terry Everett

Space and Defense

I would like to thank the Eisenhower Center for Space and Defense Studies and the Center for Strategic and International Studies for the invitation to speak today. I would also like to thank Dr. Hamre , Ambassador Harrison, and Peter Teets for their leadership. Peter Teets is a good friend and great space leader and I am honored to be among such individuals who I hold in high regard.

Segment Anything Model (Sam) And Teachable Machine May Be Useful Tools For Identifying Risky Tackle Biomechanics In Still Shot Images Of American Football Tackle., Sean Chin Loy, Scott Dietrich

International Journal of Exercise Science: Conference Proceedings

Teachable Machine (TM) is a web-based tool from google that makes creating machine learning models fast, easy, and accessible to everyone. PURPOSE: To explore novel AI-based approaches using the Segment Anything Model (SAM) and Teachable Machine to classify still images for identification of tackles with good versus risky biomechanics. SAM provided by Meta AI is a prompt-able, image segmentation system with zero-shot generalization to unfamiliar objects, without the need for additional training. This technology may be a useful tool for identifying and categorizing bad (risky, head down) tackles in screenshot images of American football tackle videos taken when players contacted …

Effects Of Blood Flow Restricted Ballet Classes To Improve Strength And Balance In Older Females, Ann-Jovita Saminathar, Emma Hsiaowen Chen, Andreas Bergdahl, Mary Roberts

International Journal of Exercise Science: Conference Proceedings

Falls in New York State result in 60% of older adults ending up in nursing homes or rehabilitation centres, with 27% experiencing hip fractures. These falls are the primary cause of two-thirds of deaths, often due to age-related postural stability decline. Fortunately, exercise offers a solution to address this decline. Consequently, engaging in online exercise programs at home can effectively enhance postural stability, along with using blood flow restriction (BFR) techniques to increase strength even with lower intensity exercise levels. PURPOSE:This study investigates whether online dance classes with BFR can improve strength and postural stability of women aged 65 …

Five Minutes Of Psychological Skills Training Intervention Increase Mental Toughness Levels In Females Athletes, Alex J. Barber, Andreas Stamatis

International Journal of Exercise Science: Conference Proceedings

Mental toughness (MT) is conceptualized as a dynamic psychological resource conducive to goal-oriented pursuits and linked with sport performance outcomes. Despite the recognized importance of psychological interventions in sports, constraints often hinder their implementation during competitive seasons, especially on the individual level. Female representation in MT research remains limited. Psychological Skills Training (PST) is a systematic approach used in sport psychology to enhance athletes’ mental skills and abilities. PURPOSE: To investigate the impact of a brief, face-to-face, individualized PST intervention on MT levels among female athletes. METHODS: All 14 members of a Division III female volleyball team ( …

Comprehensive Evaluation Of Hip Arthroscopy For Elite Athletes With Femoroacetabular Impingement And Associated Pathology, Billal Siddiq, Nikolaos Gravvanis, Georgios Tsikouris, Andreas Stamatis

International Journal of Exercise Science: Conference Proceedings

Femoroacetabular impingement (FAI) is a recognized source of debilitating hip pain among elite athletes. Hip arthroscopy, including labral repair, and FAI lesion correction have been gaining notoriety as methods to mitigate pain and enable athletes to return to their respective sports. PURPOSE: To provide a comprehensive understanding of the clinical presentation, surgical intervention, and outcomes of elite athletes suffering from hip pain attributed to FAI and associated pathology. METHODS: Elite athletes (n = 35; females = 12) from various sports, including basketball, soccer, martial arts, water polo, and weightlifting, participated. Following unsuccessful conservative management (e.g., analgesic medications, …

Bilateral Differences In Vascular Stiffness And Blood Pressure Of Female College Tennis Players And Controls, Chanhtel E. Thongphok, Abena O. Gyampo, Anneli O. Ramolins, Elianna G. Hills, Claire E. Coates, Stephen J. Ives

International Journal of Exercise Science: Conference Proceedings

Vascular stiffness is highly correlated to cardiovascular disease (CVD) and has been attenuated by regular aerobic exercise in older adults. Additionally, body composition strongly predicts vascular stiffness and CVD risk. Previous research has documented that bilateral differences in shear stress lead to differences in vascular endothelial function in tennis players. However, whether this translates into bilateral differences in vascular stiffness and blood pressure remains to be elucidated. The SphygmoCor is a gold standard for assessing arterial stiffness but is not readily accessible. In comparison, the TicWatch GTH Pro, which uses the SphygmoCor algorithm to provide a cardiovascular health (CVH) score …

Association Of Body Composition Methods And Occupational Readiness: Differences Between Veterans And Rookies, Vinicius L Ribeiro, Peter Beitia, Andreas Stamatis, Zacharias Papadakis

International Journal of Exercise Science: Conference Proceedings

The increasing prevalence of obesity among United States firefighters has prompted concerns. Current guidelines from National Fire Protection Association 1582 rely on body mass index (BMI) for obesity assessment. However, BMI’s inability to distinguish between fat and lean mass raises validity issues. An alternative measurement, body fat percentage (BF%) has emerged as a potentially more accurate tool for assessing obesity. Moreover, the widely used Physical Ability Test (PAT) may face complexities in evaluating firefighters' readiness due to variations in body composition (BC) among individuals. Additionally, the combined influence of years in service, BC variations, and the aforementioned factors could potentially …

Body Mass Index Misclassify Obesity In Firefighters, Samuel R. Vilmeau, Peter Beitia, Andreas Stamatis, Zacharias Papadakis

International Journal of Exercise Science: Conference Proceedings

Among firefighters the issue of obesity has gained significant attention due to its correlation with adverse health consequences. The National Fire Protection Association 1582 has endorsed the utilization of the body mass index (BMI) to assess obesity. However, long-standing concerns have emerged regarding BMI's reliability in accurately representing body composition (BC), especially in distinguishing between lean and fat mass. Firefighters' work is physically demanding, which often leads to increased muscle mass, BMI use may misclassify them as obese. This can result in false positives where firefighters are categorized as obese based on BMI even when their BC aligns with non-obese …

Exploring The Role Of Mental Toughness In Bone Mineral Content: A Preliminary Study, Marissa Zeno, Tomas Chapman-Lopez, Ricardo Torres, Jordan Ledington, Madelin R. Siedler, Christian Rodriguez, Jeff S. Forsse, Grant M. Tinsley, Andreas Stamatis

International Journal of Exercise Science: Conference Proceedings

Bone mineral content (BMC), a measure of the mineral content within a person’s bones, is an important parameter in the assessment of bone health. Changes in BMC can be indicative of bone-related conditions. Dual-energy X-ray absorptiometry (DXA) is one of the most widely used and accurate methods for measuring BMC. Sex, age, race, and BMI are known to influence BMC. Physical activity is positively related to BMC levels. Mental toughness (MT) is conceptualized as a state-like psychological resource conducive to goal-oriented pursuits and is positively linked to physical activity outcomes. The relationship between MT and BMC has not been explored. …

Inter-Rate Reliability Of Mental Toughness Scores By Head And Assistant Coaches: A Repeated-Measure Design, Maya Caon, Charlotte Armstrong, Andreas Stamatis, Claire Egret, Tal Amasay, Zacharias Papadakis

International Journal of Exercise Science: Conference Proceedings

Mental toughness (MT) is a crucial attribute in sports, often linked to superior performance. Female sports such as rowing are underrepresented in MT research. In addition, MT research has primarily relied on cross-sectional self-assessment, raising questions about the reliability of scores. Recently, external evaluation (e.g., supervisors, peers, experts) has been proposed as an alternative method of MT assessment. PURPOSE: To investigate the inter-rater reliability (IRR) of MT assessments provided by the head coach (HC) and the assistant coach (AC) in the context of collegiate female rowing, using a repeated-measure design. METHODS: Twelve Division II female rowers (Age: 20.8 …

Physical Activity Assessment Of People With Type Ii Diabetes In The Dominican Republic, Camille H. Palarpalar, Kristen Green, Mónica Ortiz Rossi, Alex Rothstein, Lillian B. Niwagaba, Amerigo Rossi

International Journal of Exercise Science: Conference Proceedings

The prevalence of type II diabetes has increased nearly 25% in the past 10 years, leading to significantly higher risk of morbidity and premature mortality. Although it is well-known that physical activity (PA) improves diabetes outcomes, little is known about PA among Dominicans. PURPOSE: To evaluate PA participation and perceptions among people with type II diabetes in the Dominican Republic (DR). METHODS: Participants (N=29) were recruited from an urban diabetes clinic in Nagua, DR. Age, height, and weight were self-reported. Actigraph wGT3X-BT triaxial accelerometers were fitted for wear on the non-dominant wrist, and participants were instructed not to change their …

Lower Extremity Injury And Y-Balance Scores In Division I Women’S Soccer, Lianne Emanuel, Amelia Heywood, Tyler Mcgivney, Adam Gonzalez, Jamie Ghigiarelli, Kelly Shaver, Roger Gerland, Katie Sell

International Journal of Exercise Science: Conference Proceedings

The Y-Balance Test (YBT) is a functional, portable assessment used to examine stability and mobility in the lower extremities (LE). However descriptive YBT data and how scores may compare across healthy and previously injured women’s soccer players is scarce but in demand. PURPOSE: The purpose of this study was to explore the difference in YBT scores in female collegiate-level soccer athletes with and without a recent history of LE injury. METHODS: Twenty-two Division I female soccer players completed a YBT during pre-season. All of the subjects were cleared for testing by the head athletic trainer and the team physician and …