Digital Commons Network^™

Clean The World: A Mission For Global Sanitation, Anisha B. Bissessar, Ahmad Shaqqou

High Impact Practices Student Showcase Fall 2023

This presentation dives into our experience volunteering at Clean the World, an organization that recycles hygiene products to deliver to families across the world who don't have access to them. We learned more about what it means to be a servant leader through the welcoming and uplifting atmosphere the people working there created for us.

Gardner-Webb Associate Professor Reflects On Life And Legacy Of Rosalynn Carter, Office Of University Communications

Gardner-Webb NewsCenter Archive

Today, people all over the world are remembering the life of former first lady, Rosalynn Carter, who passed away on Nov. 19. Gardner-Webb Associate Professor of Journalism and Communication Dr. Kortni Alston Lemon also reflected on her special relationship with Carter. Lemon, chair of the Gardner-Webb University Department of Communication, Art and Design, serves on the advisory board for the Rosalynn Carter Mental Health Journalism Fellowship. (https://mentalhealthjournalism.org/)

Integrity, Confidentiality, And Equity: Using Inquiry-Based Labs To Help Students Understand Ai And Cybersecurity, Richard C. Alexander, Liran Ma, Ze-Li Dou, Zhipeng Cai, Yan Huang

Journal of Cybersecurity Education, Research and Practice

Recent advances in Artificial Intelligence (AI) have brought society closer to the long-held dream of creating machines to help with both common and complex tasks and functions. From recommending movies to detecting disease in its earliest stages, AI has become an aspect of daily life many people accept without scrutiny. Despite its functionality and promise, AI has inherent security risks that users should understand and programmers must be trained to address. The ICE (integrity, confidentiality, and equity) cybersecurity labs developed by a team of cybersecurity researchers addresses these vulnerabilities to AI models through a series of hands-on, inquiry-based labs. Through …

New Methods For Stereoselective Glycosylation In Application To Significant Biomedical Targets, Melanie L. Shadrick

Dissertations

Glycosyl halides have been utilized for glycosylation reactions since the early studies by Arthur Michael, nearing the end of the 19^th century. Koenigs and Knorr then utilized silver salts to activate glycosyl bromides and chlorides to create synthetic glycosides. Many efforts to improve the outcome of reactions with glycosyl halides have emerged. The key emphasis has traditionally been placed on reaction rates, product yields, and stereocontrol. Recently, our lab reported that silver(I) oxide-mediated Koenigs-Knorr glycosylation reaction can be dramatically accelerated in the presence of catalytic acid additives. Methods to improve glycosylation was explored using mannosyl and glucosyl bromides. However, …

Burdin, Johannah, Samantha Rouillard

Querying the Past: LGBTQ Maine Oral History Project Collection

Johannah Burdin shares her story as a lesbian/queer woman experiencing southern Maine in the 1990s. Her story touches on topics involving coming out, relationships, a traumatic incident that left her disabled, activism, and much more. She was active in her youth in spreading awareness on the AIDS/HIV crisis, education on safe sex, and spent her evenings at popular Portland gay bars, like Sister’s Bar and Limelight/The Underground. Although she is not much into drinking, she recognized these were some of the few spots queer people could go to make community and relationships. Johannah also shares her story of becoming a …

Evaluating The Efficacy Of Chatgpt In Navigating The Spanish Medical Residency Entrance Examination (Mir): Promising Horizons For Ai In Clinical Medicine., Francisco Guillen-Grima, Sara Guillen-Aguinaga, Laura Guillen-Aguinaga, Rosa Alas-Brun, Luc Onambele, Wilfrido Ortega, Rocio Montejo, Enrique Aguinaga-Ontoso, Paul Barach, Ines Aguinaga-Ontoso

Department of Medicine Faculty Papers

UNLABELLED: The rapid progress in artificial intelligence, machine learning, and natural language processing has led to increasingly sophisticated large language models (LLMs) for use in healthcare. This study assesses the performance of two LLMs, the GPT-3.5 and GPT-4 models, in passing the MIR medical examination for access to medical specialist training in Spain. Our objectives included gauging the model's overall performance, analyzing discrepancies across different medical specialties, discerning between theoretical and practical questions, estimating error proportions, and assessing the hypothetical severity of errors committed by a physician.

MATERIAL AND METHODS: We studied the 2022 Spanish MIR examination results after excluding …

Brain-Derived Neurotrophic Factor – A Key Player In The Gastrointestinal System, Arjun Singh

Jefferson Hospital Staff Papers and Presentations

Brain-derived neurotrophic factor (BDNF) is highly expressed throughout the gastrointestinal (GI) tract and plays a critical role in the regulation of intestinal motility, secretion, sensation, immunity, and mucosal integrity. Dysregulation of BDNF signalling has been implicated in the pathophysiology of various GI disorders including inflammatory bowel disease, irritable bowel syndrome, functional dyspepsia, and diabetic gastroenteropathy. This review provides a comprehensive overview of BDNF localization, synthesis, receptors, and signalling mechanisms in the gut. In addition, current evidence on the diverse physiologic and pathophysiologic roles of BDNF in the control of intestinal peristalsis, mucosal transport processes, visceral sensation, neuroimmune interactions, gastrointestinal mucosal …

Tulathromycin Metaphylaxis Increases Nasopharyngeal Isolation Of Multidrug Resistant Mannheimia Haemolytica In Stocker Heifers, William B. Crosby, Brandi B. Karisch, Lari M. Hiott, Lee J. Pinnell, Alexandra Pittman, Jonathan G. Frye, Charlene R. Jackson, John Dustin Loy, William B. Epperson, John Blanton Jr., Sarah F. Capik, Paul S. Morley, Amelia R. Woolums

School of Veterinary and Biomedical Sciences: Faculty Publications

Bovine respiratory disease (BRD) is a leading cause of disease in feedlot and stocker calves with Mannheimia haemolytica (MH) as one of the most common etiologies. One of the most effective means of controlling BRD is through metaphylaxis, which involves administering antimicrobials to all animals at high risk of developing BRD. However, increasing prevalence of multidrug resistant (MDR) MH may reduce efficacy of metaphylaxis due to decreased susceptibility to drugs used for metaphylaxis. Primarily, this study aimed to determine the effect of tulathromycin metaphylaxis and subsequent BRD treatment on antimicrobial resistance (AMR) in MH isolated from stocker calves. Secondary objectives …

“...I Have My Dad, Sister, Brother, And Mom’S Password”: Unveiling Users’ Mental Models Of Security And Privacy-Preserving Tools, Prakriti Dumaru, Ankit Shrestha, Rizu Paudel, Cassity Haverkamp, Maryellen Mcclain Verdoes, Mahdi Nasrullah Al-Ameen

Computer Science Student Research

Purpose: Security and privacy-preserving tools (for brevity, we term them as ‘security tools’ in this paper, unless otherwise specified) are designed to protect the security and privacy of people in the digital environment. However, inappropriate use of these tools can lead to unexpected consequences that are preventable. Hence, it is significant to examine why users do not understand the security tools.

Methodology: We conducted a qualitative study with 40 participants in the USA to investigate the prevalent misconceptions of people regarding security tools, their perceptions of data access, and the corresponding impact on their usage behavior and data protection strategies. …

Mechanism Of Stepwise Electron Transfer In Six-Transmembrane Epithelial Antigen Of The Prostate (Steap) 1 And 2, Kehan Chen, Lie Wang, Jiemin Shen, Ah-Lim Tsai, Ming Zhou, Gang Wu

Faculty, Staff and Student Publications

Six transmembrane epithelial antigen of the prostate (STEAP) 1-4 are membrane-embedded hemoproteins that chelate a heme prosthetic group in a transmembrane domain (TMD). STEAP2-4, but not STEAP1, have an intracellular oxidoreductase domain (OxRD) and can mediate cross-membrane electron transfer from NADPH via FAD and heme. However, it is unknown whether STEAP1 can establish a physiologically relevant electron transfer chain. Here, we show that STEAP1 can be reduced by reduced FAD or soluble cytochrome b5 reductase that serves as a surrogate OxRD, providing the first evidence that STEAP1 can support a cross-membrane electron transfer chain. It is not clear whether …

The Contributions Of Mental Health Issues, Traumatic Brain Injury, And Adverse Childhood Experiences To Recidivism Among Rural Jail Incarcerees, Lauren N. Miley

USF Tampa Graduate Theses and Dissertations

Recidivism should be a major concern, particularly for American jails. The Unites States incarcerates 2.3 million people, a number exceeding rates in any other country. Approximately 90% of those individuals will reenter society at some point, and roughly half of those people will ultimately return to jail. This revolving door costs U.S. taxpayers upwards of $39 billion per year, and undermines public safety. Therefore, breaking this cycle of incarceration and recidivism is of utmost concern, and the focus of this dissertation. Mental health problems, traumatic brain injury (TBI), and adverse childhood experiences (ACEs) are three potential risk factors for recidivism …

The Role Of Vitamin D In Patients With Inflammatory Bowel Disease Treated With Vedolizumab, Bincy P Abraham, Christopher Fan, Theresa Thurston, Joshua Moskow, Hoda M Malaty

Faculty, Staff and Students Publications

BACKGROUND: Many clinical factors can contribute to the efficacy of medical therapy in Inflammatory Bowel Disease (IBD). We assessed their effects on the efficacy of vedolizumab therapy in a cohort of patients with IBD.

METHODS: We conducted a retrospective study on patients between 18 and 80 years of age with ulcerative colitis (UC) or Crohn's disease (CD) who were seen in the IBD program at Houston Methodist in Houston, TX and treated with vedolizumab for at least 6 months from 2018 to 2022. We investigated factors prior to the initiation of therapy that best predicted treatment response, with an emphasis …

Engineering A Novel Modular Adenoviral Mrna Delivery Platform Based On Tag/Catcher Bioconjugation, Kexin Geng, Paul J Rice-Boucher, Elena A Kashentseva, Igor P Dmitriev, Zhi Hong Lu, S Peter Goedegebuure, William E Gillanders, David T Curiel

2020-Current year OA Pubs

mRNA vaccines have attracted widespread research attention with clear advantages in terms of molecular flexibility, rapid development, and potential for personalization. However, current mRNA vaccine platforms have not been optimized for induction of CD4/CD8 T cell responses. In addition, the mucosal administration of mRNA based on lipid nanoparticle technology faces challenges in clinical translation. In contrast, adenovirus-based vaccines induce strong T cell responses and have been approved for intranasal delivery. To leverage the inherent strengths of both the mRNA and adenovirus platforms, we developed a novel modular adenoviral mRNA delivery platform based on Tag/Catcher bioconjugation. Specifically, we engineered adenoviral vectors …

Enhanced Luminescence Efficiency In Eu-Doped Gan Superlattice Structures Revealed By Terahertz Emission Spectroscopy, Fumikazu Murakami, Atsushi Takeo, Brandon Mitchell, Volkmar Dierolf, Yasufumi Fujiwara, Masayoshi Tonouchi

Physics & Engineering Faculty Publications

Eu-doped Gallium nitride (GaN) is a promising candidate for GaN-based red light-emitting diodes, which are needed for future micro-display technologies. Introducing a superlattice structure comprised of alternating undoped and Eu-doped GaN layers has been observed to lead to an order-of-magnitude increase in output power; however, the underlying mechanism remains unknown. Here, we explore the optical and electrical properties of these superlattice structures utilizing terahertz emission spectroscopy. We find that ~0.1% Eu doping reduces the bandgap of GaN by ~40 meV and increases the index of refraction by ~20%, which would result in potential barriers and carrier confinement within a superlattice …

Combatting Social Isolation In Greater Orlando, Rishi Nair, Nicholas Mistry

High Impact Practices Student Showcase Fall 2023

The state of Florida is home to one of the largest retiree and Veteran populations in the country. As people age, they are more prone to suffer from physical and mental conditions that preclude their ability to live a fulfilling life. This could result in social isolation and loneliness, which has been exacerbated by the COVID-19 pandemic. We partnered with Seniors First’s Project Connect program to improve social interactions among the elder community with virtual trivia events. These weekly games helped us identify areas of emotional need, such as improving self-esteem, introducing memories of seniors' lives when they were younger, …

Empowering Futures: Matthew's Knights Of Distinction Leadership E-Portfolio In Academic Excellence, Matthew A. Hernandez

High Impact Practices Student Showcase Fall 2023

My presentation centers on my E-Portfolio, seamlessly incorporating three key milestones from the Knights of Distinction program into significant events. Beginning with a brief personal introduction, I shared why I became a physics major, and explored the roots of my passion for space. Utilizing a visual aid, my poster board, I elucidated each focus area and its relevance to my aspirations and societal contributions. The first focus area was Citizenship and how I attended an “Industry BBQ” with the hopes of gaining valuable information to share it with other engineers. The second focus area was about leadership and my role …

Low-Dose Prednisone Or Methylprednisolone In Treating Patients With​ Newly Diagnosed Acute Gvhd​, Dillon C. Hill, Melanie Obsina, Juan Sanchez, Jordan Genco, Vihan Yalamanchili

High Impact Practices Student Showcase Fall 2023

Graft Versus Host Disease affects less than 20,000 cases per year and our project aims to give those who experience this terrible disease a better outcome and more manageable pain. The clinical trial that this data is collected from analyzes low-dose prednisone versus the standard dose and how that affects both morbidity and progression of the disease to Stage III-IV. This clinical trial has many clinical implications as it shows that reducing the dosage of commonly used treatment methods can sometimes have positive effects even though it is the standard to use a certain dose. This clinical trial found that …

11.20.2023 Orsp Connect, Liz Williamson

ORED Newsletter

ORSP Newsletter for the week of November 20, 2023.

Large Right Lower Quadrant Abdominal Mass, Isheeta Madeka, Cannon Greco-Hiranaka, Ozlem Kulak, Wilbur Bowne

Jefferson Hospital Staff Papers and Presentations

No abstract provided.

Protracted Respiratory Failure In A Case Of Global Spinal Syringomyelia And Chiari Malformation Following Administration Of Diazepam: Illustrative Case, Luke Bauerle, Brandon Rogowski, Aakash Shingala, Habib Emil Rafka, Timothy Webb, Brian F. Saway, Edward F. Kilb, Julio A. Chalela, Nathan C. Rowland

Jefferson Hospital Staff Papers and Presentations

BACKGROUND: Syringomyelia is defined as dilation of the spinal cord's central canal and is often precipitated by skull base herniation disorders. Although respiratory failure (RF) can be associated with skull base abnormalities due to brainstem compression, most cases occur in pediatric patients and quickly resolve. The authors report the case of an adult patient with global spinal syringomyelia and Chiari malformation who developed refractory RF after routine administration of diazepam.

OBSERVATIONS: A 31-year-old female presented with malnutrition, a 1-month history of right-sided weakness, and normal respiratory dynamics. After administration of diazepam prior to magnetic resonance imaging (MRI), she suddenly developed …

The Echo: November 20, 2023, Taylor University

2023-2024 (Volume 111)

No abstract provided.

2023-November-20-Wets-Fm Promoting Npr College Podcast Challenge.Pdf, University Marketing And Communication, East Tennessee State University

ETSU News

Local college students who are aspiring podcasters can compete for their podcast to be showcased nationally in the third annual “College Podcast Challenge,” hosted by NPR.

The competition is open for submissions until Jan 5, 2024. As in years past, the challenge is the same: produce a podcast between three and eight minutes on a topic, issue or story of your choosing. The winner will receive a $5,000 scholarship and $500 will be awarded to finalists. The grand prize winner and finalists will be notified in February 2024.

Chad Barrett, station director at WETS-FM, recently interviewed Janet Woojeong Lee, …

Integration Of Algae And Biomass Processes To Synthesize Renewable Bioproducts For The Circular Economy, Jessica Martin

USF Tampa Graduate Theses and Dissertations

Rapid population growth and global industrialization have substantially heightened the demand for fossil-based fuels and products in various sectors of the global economy, including energy production, transportation fuels, and as raw materials for petrochemicals. The intense consumption of fossil fuels has caused immense environmental impacts, especially pertaining to carbon dioxide emissions. Shifting to renewable feedstocks (raw materials) is expected to reduce these emissions by lowering the carbon footprint of fuels and products compared to traditional fossil-derived alternatives. This transition aligns with the goal of creating a sustainable and circular economy, emphasizing efficient resource use, and reducing waste generation through recycling …

Effects Of The Timing Of A Repeated Reading Intervention On Active Student Responding During Small Group, Kristen Newell

LSU Master's Theses

Interventions that target both class engagement and academic skills may decrease the likelihood of future reading difficulties in elementary students, amongst other academic deficits. Repeated reading can be used as either a pre-teaching or review strategy to increase overall fluency and comprehension, but the timing of when the intervention is arranged may be important for increasing active student responding (ASR) during class. In this study, we examined how the timing of a repeated reading intervention, as either preparation for or review of reading material, affects active student responding during a small group of three fourth-grade students. Additionally, we investigated student …

The Social And Emotional Experiences Of Gen Z Who Are Caring For An Older Family Member, Alisa C. Norris

Walden Dissertations and Doctoral Studies

No abstract provided.

Intouch Week Of November 20, 2023, New York Medical College

InTouch

• SOM Class of 2027Celebrates Friendsgiving
• GSBMS Pens Conditional Admittance and Guaranteed Interview Agreements with TUCOM
• NYMC Raises More than $5,000 for Victims of the Israeli-Palestinian Conflict

Vaginal Microbial Dynamics And Pathogen Colonization In A Humanized Microbiota Mouse Model, Marlyd E Mejia, Vicki Mercado-Evans, Jacob J Zulk, Samantha Ottinger, Korinna Ruiz, Mallory B Ballard, Stephanie W Fowler, Robert A Britton, Kathryn A Patras

Faculty, Staff and Students Publications

Vaginal microbial composition is associated with differential risk of urogenital infection. Although Lactobacillus spp. are thought to confer protection against infection, the lack of in vivo models resembling the human vaginal microbiota remains a prominent barrier to mechanistic discovery. Using 16S rRNA amplicon sequencing of C57BL/6J female mice, we found that vaginal microbial composition varies within and between colonies across three vivaria. Noting vaginal microbial plasticity in conventional mice, we assessed the vaginal microbiome of humanized microbiota mice (

In Vivo Volumetric Depth-Resolved Imaging Of Cilia Metachronal Waves Using Dynamic Optical Coherence Tomography, Tian Xia, Kohei Umezu, Deirdre M Scully, Shang Wang, Irina V Larina

Faculty, Staff and Students Publications

Motile cilia are dynamic hair-like structures covering epithelial surfaces in multiple organs. The periodic coordinated beating of cilia creates waves propagating along the surface, known as the metachronal waves, which transport fluids and mucus along the epithelium. Motile ciliopathies result from disrupted coordinated cilia beating and are associated with serious clinical complications, including reproductive disorders. Despite the recognized clinical significance, research of cilia dynamics is extremely limited. Here, we present quantitative imaging of cilia metachronal waves volumetrically through tissue layers using dynamic optical coherence tomography (OCT). Our method relies on spatiotemporal mapping of the phase of intensity fluctuations in OCT …

The Effect Of Social Support On Social Media On Asian College Students' Intention To Participate In Physical Activity In The United States, Ni Zhang, Kele Ding, Chulwoo Park, Jane Vo, Katrina Marie Cantos

Faculty Research, Scholarly, and Creative Activity

Background: College students who identified themselves as Asians in the United States (i.e., Asian college students) are facing health inequalities and engaging in increasingly low levels of physical activity (PA). Although social support was found to be effective in increasing college students' PA and social media is an important channel for social support for Asian students, few studies have explored how to provide social support through social media interventions to promote Asian students' PA level. Thus, this study aimed to explore the effects of social support on social media on Asian college students' intention to participate in PA based on …

Mechanisms, Evolution, And Rapid Diagnosis Of Carbapenem Resistance, Taalin Shale Hoj

Theses and Dissertations

An estimated 70% of bacterial infections in the United States are resistant to first-line antibiotics. Of these, among the most difficult to treat are highly resistant to carbapenems, an antibiotic class used as a last resort. Septicemia, particularly when caused by a carbapenem-resistant organism, is among the most challenging clinical scenarios to treat, with an overall mortality rate of carbapenem-resistant septicemias 63.8%. Encouragingly, if effective antimicrobial treatment begins within 1-3 hours of septic shock onset, patient survival rates are around 80%. The first section of this work describes a real-time PCR-based assay that when coupled with existing bacteria-blood separation technology, …