Methods For Analytical And Biophysical Analysis For Investigation Of Stimulator Of Interferon Genes In Drug Discovery, William Emmett Brian Lawless

USF Tampa Graduate Theses and Dissertations

This work elaborates on analytical and biophysical techniques including high pressure liquid chromatography (HPLC), mass spectrometry quadrupole time-of-flight (MS-QToF), dynamic light scattering (DLS), microscale thermophoresis (MST), surface plasmon resonance (SPR), isothermal calorimetry (ITC), size exclusion chromatography, and native gel electrophoresis. A basic overview is described for each technique and is designed for easy understanding by both novice and experienced analysts. Best practices for each technique are discussed and suggestions are made for protocol improvements or troubleshooting. Protocol development is discussed, and a method is introduced for MST that can be adapted to any target protein for rapid screening of analog …

Silver Bow Creek Butte Area Npl Site 2024 Draft Final Butte Priority Soils Operable Unit Interim Site-Wide Surface Water Monitoring Quality Assurance Project Plan. Consent Decree- Civil Action No. Cv 89-039-Bu-She, Woodard & Curran

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Multi-Center Clinical Evaluation Of The Panther Fusion Sars-Cov-2/Flu A/B/Rsv Assay In Nasopharyngeal Swab Specimens From Symptomatic Individuals., Anjana Sasidharan, Rangaraj Selvarangan, Kennah Konrad, Matthew L. Faron, Salika M. Shakir, David Hillyard, Robert K. Mccall, Ian H. Mchardy, David C. Goldberg, James J. Dunn, Alexander L. Greninger, Christine Lansang, Rachel Bogh, Carmelle V. Remillard

Manuscripts, Articles, Book Chapters and Other Papers

The symptomology is overlapping for respiratory infections due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), influenza A/B viruses, and respiratory syncytial virus (RSV). Accurate detection is essential for proper medical management decisions. This study evaluated the clinical performance of the Panther Fusion SARS-CoV-2/Flu A/B/RSV assay in nasopharyngeal swab (NPS) specimens from individuals of all ages with signs and symptoms of respiratory infection consistent with COVID-19, influenza, or RSV. Retrospective known-positive and prospectively obtained residual NPS specimens were collected during two respiratory seasons in the USA. Clinical performance was established by comparing Panther Fusion SARS-CoV-2/Flu assay results to a three-molecular assay …

3dgaunet: 3d Generative Adversarial Networks With A 3d U-Net Based Generator To Achieve The Accurate And Effective Synthesis Of Clinical Tumor Image Data For Pancreatic Cancer, Yu Shi, Hannah Tang, Michael J. Baine, Michael A. Hollingsworth, Huijing Du, Dandan Zheng, Chi Zhang, Hongfeng Yu

School of Computing: Faculty Publications

Pancreatic ductal adenocarcinoma (PDAC) presents a critical global health challenge, and early detection is crucial for improving the 5-year survival rate. Recent medical imaging and computational algorithm advances offer potential solutions for early diagnosis. Deep learning, particularly in the form of convolutional neural networks (CNNs), has demonstrated success in medical image analysis tasks, including classification and segmentation. However, the limited availability of clinical data for training purposes continues to represent a significant obstacle. Data augmentation, generative adversarial networks (GANs), and cross-validation are potential techniques to address this limitation and improve model performance, but effective solutions are still rare for 3D …

Multi-View Information Fusion Using Multi-View Variational Autoencoder To Predict Proximal Femoral Fracture Load, Chen Zhao, Joyce H. Keyak, Xuewei Cao, Qiuying Sha, Li Wu, Zhe Luo, Lan Juan Zhao, Qing Tian, Michael Serou, Chuan Qiu, Kuan Jui Su, Hui Shen, Hong Wen Deng, Weihua Zhou

Michigan Tech Publications

Background: Hip fracture occurs when an applied force exceeds the force that the proximal femur can support (the fracture load or “strength”) and can have devastating consequences with poor functional outcomes. Proximal femoral strengths for specific loading conditions can be computed by subject-specific finite element analysis (FEA) using quantitative computerized tomography (QCT) images. However, the radiation and availability of QCT limit its clinical usability. Alternative low-dose and widely available measurements, such as dual energy X-ray absorptiometry (DXA) and genetic factors, would be preferable for bone strength assessment. The aim of this paper is to design a deep learning-based model to …

20231121_Hslic's Student Computing Updated With Statistical Software, Tim Mey

HSLIC Blog Post

No abstract provided.

Revealing Tarumanagara Kingdom Indigenous Knowledge From The Jakarta History Museum Collections, Rizki Nurislaminingsih, Heriyanto Heriyanto

Library Philosophy and Practice (e-journal)

Tarumanagara is the oldest kingdom in Java island with its territory along the west coast of Java island. Their socio-cultural was diverse which were created by the people who live in every region of Java. Their legacy is now preserved in the Jakarta History Museum which tell about the Tarumanagara indigenous knowledge. This study aims to identify the knowledge through the Jakarta History Museum collections. Museum studies approach was employed to identify the indigenous knowledge of Tarumanagara people. The findings show that behind the the Jakarta History Museum collections there are stories that represent the indigenous knowledge of the Tarumanagara …

Comparative Study Of Academic Performance Of Undergraduates Admitted Through Utme, Pre-Degree And Direct-Entry Into The Federal University Of Technology, Owerri., Felix M. Eke Dr, Ngozi Chima-James Dr, Peter O. Moneke Dr

Library Philosophy and Practice (e-journal)

In this research on comparative study of academic performance of undergraduates admitted through UTME, Pre-Degree and Direct-Entry into the Federal University of Technology, Owerri. Seven (7) Schools/Faculties were randomly drawn for the study, from where sixteen (16) departments were randomly selected and the CGPA of their graduated students 2011/2012 – 2015/2016 used for the research. A total population of 1280 students out of which a sample of 668 students’ CGPA across the departments were drawn. We analyzed the CGPA data using different sample sizes for each admission mode and found that the average performance of graduated students, their standard deviation, …

How To Celebrate Food-Centered Holidays Through Disordered Eating Recovery, Anna Jones

Browse All News

No abstract provided.

Butte Priority Soils Operable Unit (Bpsou) New And Mahoney Remedial Action Work Plan (Rawp) Request For Change, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

An Exploration Of Leadership And Management Challenges Among Center-Based Early Childhood Education Directors, Yeni Portillo-Lemus

Doctor of Education Program Dissertations

Managing early childhood education (ECE) programs is intricate, with directors facing challenges in organizational leadership, business management, and meeting pedagogical standards. Early childhood education directors are vital as they play a crucial role in ensuring quality education and care. Despite the importance, research on leadership and management, especially through a gender lens, is limited. Therefore, the purpose of this qualitative narrative inquiry was to explore the leadership and management challenges Los Angeles County based, private-for-profit, single-center early childhood education directors experience in their leadership and management roles. Six participants who self-identified as ECE directors completed semi-structured interviews over Zoom. These …

Growth Components And Yield Of Brachiaria Ruziziensis (Congo Grass) And Centrosema Pascuorum (Centro) Mixtures As Influenced By Mixture Ratios, Phosphorus Levels And Stage Of Harvest, I. Sani, J. T. Amodu, R. J. Tanko, M. R. Hassan, N. Adamu

IGC Proceedings (1977-2023)

This study was conducted during the 2017 and 2018 rainy season at the Crop Production Research farm, Abubakar Tafawa Balewa University, Bauchi to determine the effects of plant mixture ratios in Brachiaria ruziziensis and Centrosema pascuorum (100% Sole B. ruziziensis, 75% B.R: 25% C.P, 50% B.R: 50% C.P, 25% B.R: 75% C.P and 100% Sole C. pascuorum) and phosphorus fertilizer (SSP) levels (0, 100 and 150kg/ha). The experiment was in a split-plot design with 5x3 factorial arrangement in which the mixture ratios constituted the main plots while phosphorus (SSP) levels constituted the sub treatments. Number of plants per …

Increasing Pathways To Medicine And Improving Patient Outcomes: A Multi-Systems Approach, David S. Buck, Robert D. Sanborn, Jessica Mantel, Kenya Steele

Journal of Applied Research on Children: Informing Policy for Children at Risk

No abstract provided.

Online Assessment In Large Undergraduate Courses During Covid-19 Emergency Response Teaching, Kate Maloney Williams, Alice E. Donlan

Journal of Educational Research and Practice

The transition to online instruction during the COVID-19 pandemic was unprecedented and forced many universities to quickly embrace online distance learning. This context created new challenges, particularly around assessment strategies. Empirical research has demonstrated that formative assessment fosters more active learning in online classrooms. However, formative assessment strategies are not always adapted well to online platforms based on the nature of the subject matter and the size of the class. This qualitative case study sought to understand instructors’ experiences and strategies for conducting assessment remotely, specifically for large-size undergraduate courses. The investigation relied on data from semi-structured interviews with University …

Position Statement On In-Hospital/Clinic Point-Of-Care Coagulation Testing For Anticoagulation Monitoring In Saudi Arabia, Fakhr Al Ayoubi, Malak Al Mashali, Mohamed Hassan Abdallah, Mohamed Al Sheef, Tarek Owaidah

Journal of the Saudi Heart Association

Objectives: Hospital overload is a persistent occurrence in daily practice. Interventions such as point-of-care testing (POCT) are needed to alleviate the pressure faced by healthcare providers and administrators. Methods: An invited panel of experts from Saudi Arabia was formed under the auspices of the Saudi Heart Association in order to discuss local treatment gaps in the management of patients receiving anticoagulation therapy. This was done in a series of meetings, which resulted in the development of official recommendations for the implementation of POCT for anticoagulation monitoring in the country. Recommendations were based on a comprehensive literature review and international guidelines …

Adaptive Leadership: A Phenomenological Study On The Strategies Used By Special Education Directors To Build Adaptive Capacity, Amber Gallagher

Dissertations

Purpose: The purpose of this exploratory phenomenological study was to identify and describe the strategies used by special education directors to build an adaptive capacity based on the five key characteristics of adaptive leadership identified by Heifetz et al. (2009).

Methodology: This phenomenological study explored the lived experiences of special education directors serving in unified public school districts in Los Angeles, Orange, and San Bernardino counties in California. Purposeful, convenience sampling was used to identify the 10 participants who met the study’s criteria. The semistructured, open-ended interview protocol was developed by a thematic research team of nine peer researchers and …

Medical School Watercooler Newsletter - November 20, 2023, Lindsey Lyle

Watercooler Newsletter

This is the November 20, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Students and residents celebrate The Art of Medicine
• Kilgo presents results of using unique blood test at world MS research meeting 

Diet-Mediated Heart Disease Risk Via The Gut Microbiome: A Systematic Review Of Human Intervention Studies, Emily Bolton

Honors Capstone Projects and Theses

No abstract provided.

Real-Time Arrhythmia Detection Using Convolutional Neural Networks, Thong Vu, Tyler Petty, Kemal Yakut, Muhammad Usman, Wei Xue, Francis M. Haas, Robert A. Hirsh, Xinghui Zhao

Henry M. Rowan College of Engineering Departmental Research

Cardiovascular diseases, such as heart attack and congestive heart failure, are the leading cause of death both in the United States and worldwide. The current medical practice for diagnosing cardiovascular diseases is not suitable for long-term, out-of-hospital use. A key to long-term monitoring is the ability to detect abnormal cardiac rhythms, i.e., arrhythmia, in real-time. Most existing studies only focus on the accuracy of arrhythmia classification, instead of runtime performance of the workflow. In this paper, we present our work on supporting real-time arrhythmic detection using convolutional neural networks, which take images of electrocardiogram (ECG) segments as input, and classify …

A Formative Evaluation Of ‘Mind Matters: Overcoming Adversity And Building Resiliency’ With Hispanic Adolescents Prior To And During Covid‑19, Heidi Adams Rueda, Abigail Vera, Arminda Marcial, Amanda Mariano

Social Work Faculty Publications

Youth living in poverty are more likely to experience cumulative stressors including multiple adverse childhood events. Further, the Covid-19 pandemic has disproportionality affected Hispanic youth and communities, leading to unprecedented levels of trauma. This research responded to a need for a youth resiliency-building program in an urban and impoverished area with a majority Hispanic population. We conducted a formative evaluation of a youth intervention entitled Mind Mat- ters: Overcoming Adversity and Building Resilience, which aims to help youth overcome adversity and to build resilience via psychoeducation and skill development. Just prior to the pandemic in the United States (August-December, …

Generation Of Glucocorticoid-Producing Cells Derived From Human Pluripotent Stem Cells., Gerard Ruiz-Babot, Ariane Eceiza, Fernando Abollo-Jiménez, Maria Malyukov, Diana L Carlone, Kleiton Borges, Alexandra Rodrigues Da Costa, Shamma Qarin, Takuya Matsumoto, Ryuji Morizane, William C Skarnes, Barbara Ludwig, Paul J Chapple, Leonardo Guasti, Helen L Storr, Stefan R Bornstein, David T Breault

Faculty Research 2023

Adrenal insufficiency is a life-threatening condition resulting from the inability to produce adrenal hormones in a dose- and time-dependent manner. Establishing a cell-based therapy would provide a physiologically responsive approach for the treatment of this condition. We report the generation of large numbers of human-induced steroidogenic cells (hiSCs) from human pluripotent stem cells (hPSCs). Directed differentiation of hPSCs into hiSCs recapitulates the initial stages of human adrenal development. Following expression of steroidogenic factor 1, activation of protein kinase A signaling drives a steroidogenic gene expression profile most comparable to human fetal adrenal cells, and leads to dynamic secretion of steroid …

"Operation Motivation" - Samuel Shepard Jr., Nicalee Stephens-Wilson

Dissertations

African-American students have often faced systemic oppression and racial inequities as learners in the United States. Public schools in their communities lacked the resources to offer full access to a fair and equitable education. For years, human rights activists fought for radical changes in public schools. Finally, in 1954, the U. S. Supreme Court in Brown v. Board of Education ruled segregation in public schools unconstitutional. The Brown decision did not have the power to eliminate the long-established segregation practices. Nor did it grant access to educational equity for children of color. Dr. Samuel Shepard Jr. began his work in …

Muhammad Leach V. Kathleen Biscoe

2023 Decisions

USDC for the Middle District of Pennsylvania

Evidence-Based Intervention For Decreasing Chronic Kidney Progression In Patients With Type Ii Diabetes Mellitus, Lynn M. Johnson

Student Scholarly Projects

Practice Problem: The overall management of Type II Diabetes Mellitus (DM II) and the complications that accompany along with comorbidities are debilitating and financially exhausting. The American Diabetes Association dietary recommends a consistent low-carbohydrate diet to maintain optimal blood glucose levels to prevent complications and progression of other comorbidities. Uncontrolled diabetes mellitus leads to the development of chronic kidney disease (CKD) which can lead to the progression to End Stage Renal Disease.

PICOT: In patients in the outpatient setting aged 18 years and older(P), how does the ADA dietary guidelines for patients with type II DM(I) compared with patients self-reported …

Improving Access To Cardiac Catheterization, Sunitha Dharman

Student Scholarly Projects

The American Heart Association lists cardiovascular disease as the underlying cause of death for 874,613 people who lost their lives in 2019 (Tsao et al., 2022). On average, someone in the United States has a myocardial infarction every 40 seconds, and someone dies of a stroke every 3 minutes and 30 seconds. Studies support coronary artery disease as a significant contributor to cardiac arrest in a non-hospital setting (Yannopoulos et al., 2019). The authors provide evidence supporting the importance of early cardiac catheterization. There is a 10-15% survival rate with a higher level of functioning compared to delayed or no …

Jewish Music Sound Recording Collections In The United States, Judith S. Pinnolis

Faculty Works

This chapter examines several significant Jewish music sound-recording collections in the United States, most of which originated as private collections but are now housed at academic institutions. Their origins provide insight into individual agency tied to different understandings of Jewish music. A discussion of their complexities from a library-science perspective focuses on conservation and preservation as well as bibliographic control and other issues in which the complexities of Jewish music unfold more clearly. Authenticity, comprehensiveness, and other constructions demonstrate how sound-recording collections reflect the overall difficulties of defining and delimiting Jewish music. Subsequent discussions and observations on access and audiences …

Promoting The Adoption Of Double Gloving Among Nurse Anesthetists: An Educational Intervention Based On The Theory Of Planned Behavior, Nguyet Tran

Doctoral Projects

Abstract

Background: The role of anesthetists in the transmission of pathogenic and non-pathogenic organisms from their work station to the patient has been well established in research. The proposed study aims to test the efficacy of an educational intervention in promoting double gloving in an effort to minimize the risk of cross-contamination.

Methods: This pilot study explored if multi-component educational intervention facilitates the adoption of double gloving and the prevention of cross-contamination in the anesthesia workstation. Student Registered Nurse Anesthetists (SRNAs) and Certified Registered Nurse Anesthetists (CRNAs) were followed in three evaluation phases; the first test was done before the …

Mechanisms And Opportunities For Rational In Silico Design Of Enzymes To Degrade Per- And Polyfluoroalkyl Substances (Pfas), Melissa Marciesky, Diana S. Aga, Ian M. Bradley, Nirupam Aich, Carla Ng

Department of Civil and Environmental Engineering: Faculty Publications

Per and polyfluoroalkyl substances (PFAS) present a unique challenge to remediation techniques because their strong carbon−fluorine bonds make them difficult to degrade. This review explores the use of in silico enzymatic design as a potential PFAS degradation technique. The scope of the enzymes included is based on currently known PFAS degradation techniques, including chemical redox systems that have been studied for perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) defluorination, such as those that incorporate hydrated electrons, sulfate, peroxide, and metal catalysts. Bioremediation techniques are also discussed, namely the laccase and horseradish peroxidase systems. The redox potential of known reactants and …

Combating Invasive Species Through The Removal Of Pollution, Sarah J. Howell

High Impact Practices Student Showcase Fall 2023

The purpose of my project is to bring awareness to the issues of pollution on campus as well as encourage others to be more involved on campus through volunteerism. My time with the National Residence Hall Honorary (NRHH) and the Arboretum was very valuable. Not only was I able to learn how to identify/properly remove invasive species from an environment as well as how to generally help maintain the gardens at UCF but I was also able to learn about the value of community and working towards a common goal such as cleaning up Greek road. A Key activity that …

A Comprehensive Approach To Supporting Homeless Communities Through Free Clinical Screenings, Nivedha Srinivasan, Ria Gupta, Manasi Prakash

High Impact Practices Student Showcase Fall 2023

Hearts for the Homeless Orlando is a part of an international organization that is “focused on eliminating health disparities through practicing preventative healthcare and providing free healthcare services.” At each event, free heart health and eye health screenings and education are given to the homeless population in Downtown Orlando. Once arriving at the screening location (Christian Service Center), a table is set up with 2 blood pressure monitors, the KardiaMobile EKG Monitor, hand sanitizing wipes, germicidal wipes, gloves, and pamphlet handouts. These supplies help volunteers understand the health conditions of the individuals who visit to the site, and allow volunteers …