A Novel Tailed Primer Nucleic Acid Test For Detection Of Hpv 16, 18 And 45 Dna At The Point Of Care, Megan M Chang, Ariel Ma, Emilie Newsham Novak, Maria Barra, Kathryn A Kundrod, Jane Richards Montealegre, Michael E Scheurer, Philip E Castle, Kathleen Schmeler, Rebecca Richards-Kortum

Center for Medical Ethics and Health Policy Staff Publications

Cervical cancer is a leading cause of death for women in low-resource settings despite being preventable through human papillomavirus (HPV) vaccination, early detection, and treatment of precancerous lesions. The World Health Organization recommends high-risk HPV (hrHPV) as the preferred cervical cancer screening strategy, which is difficult to implement in low-resource settings due to high costs, reliance on centralized laboratory infrastructure, and long sample-to-answer times. To help meet the need for rapid, low-cost, and decentralized cervical cancer screening, we developed tailed primer isothermal amplification and lateral flow detection assays for HPV16, HPV18, and HPV45 DNA. We translated these assays into a …

Widespread Brca1/2-Independent Homologous Recombination Defects Are Caused By Alterations In Rna-Binding Proteins, Daniel J Mcgrail, Yang Li, Roger S Smith, Bin Feng, Hui Dai, Limei Hu, Briana Dennehey, Sharad Awasthi, Marc L Mendillo, Anil K Sood, Gordon B Mills, Shiaw-Yih Lin, S Stephen Yi, Nidhi Sahni

Faculty, Staff and Student Publications

Defects in homologous recombination DNA repair (HRD) both predispose to cancer development and produce therapeutic vulnerabilities, making it critical to define the spectrum of genetic events that cause HRD. However, we found that mutations in BRCA1/2 and other canonical HR genes only identified 10%-20% of tumors that display genomic evidence of HRD. Using a networks-based approach, we discovered that over half of putative genes causing HRD originated outside of canonical DNA damage response genes, with a particular enrichment for RNA-binding protein (RBP)-encoding genes. These putative drivers of HRD were experimentally validated, cross-validated in an independent cohort, and enriched in cancer-associated …

Changes In Fecal Glucocorticoid Metabolites In Captive Coyotes (Canis Latrans): Influence Of Gender, Time, And Reproductive Status, Eric M. Gese, Patricia A. Terletzky, Cole A. Bleke, Erika T. Stevenson, Susannah S. French

Wildland Resources Faculty Publications

Reproduction is considered an energetically and physiologically demanding time in the life of an animal. Changes in physiological stress are partly reflected in changes in glucocorticoid metabolites and can be measured from fecal samples. We examined levels of fecal glucocorticoid metabolites (fGCMs) in 24 captive coyotes (Canis latrans) to investigate responses to the demands of reproduction. Using 12 pairs of coyotes (five pairs produced pups, seven pairs did not), we analyzed 633 fecal samples covering 11 biological periods (e.g., breeding, gestation, and lactation). Levels of fGCMs showed high individual variability, with females having higher fGCM levels than males. …

Mitigating Sunk Cost Bias For Consumers: Considering Alternatives Within High And Low Construal Levels When Costs Are Sunk, Jasmine N. Ahmad

College of Science and Health Theses and Dissertations

Abstract

This paper explores how sunk costs increase consumers’ vulnerability to fraud and explores possible intervention strategies. Sunk cost bias occurs when individuals persist in an activity due to past investments (Arkes & Blumer, 1985). Outcome salience, framing, and alternatives can help alleviate loss aversion and persistence when costs are sunk (Stewart, Chater, Stott, & Reimers, 2003; Van Schie & Van Der Pligt, 1995). Option evaluation is influenced by an individual’s construal level (Ding & Keh, 2017; Henderson, 2013; Sun, Keh, & Lee, 2019). Construal level theory (CL) describes the impact of psychological distance on thinking– with greater distance thinking …

Serving Those Who Served: Renegotiating Support And Benefits For U.S. Military Veterans With Less Than Honorable Discharges, Mariah Brennan, Emily Graham

Population Health Research Brief Series

Approximately 1 in 7 veterans are discharged from the military under less than “Honorable” conditions. Veterans with less than “Honorable” discharges experience bias and stigma related to their discharge, which can lead to elevated risk for behavioral and mental health challenges and homelessness. This brief summarizes the different military discharge types, explains how less than “Honorable” discharges can affect veteran health, identifies groups of veterans who are at risk of receiving a less than “Honorable” discharge, and makes policy recommendations for the Department of Defense (DoD), civilian employers, and community healthcare providers.

2023-November-21-Etsu To Host Indigenous Heritage Celebration For Native American Heritage Month.Pdf, University Marketing And Communication, East Tennessee State University

ETSU News

East Tennessee State University will host an Indigenous Heritage Celebration on Wednesday, Nov. 29, in observance of Native American Heritage Month.

This event will take place in The Cave on the first level of the D.P. Culp Student Center from 11 a.m.- 2 p.m. It is sponsored by the Mary V. Jordan Multicultural Center and Native American Student Organization at ETSU.

November is Native American Heritage Month, and its observance is important for educating people on the history and contributions of the Indigenous peoples.

“We have over 550 federally recognized tribes in the United States alone,” said Dr. Deborah Thibeault, …

2023 November 21, Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes No. 6; November 21, 2023

Hyperspectral Analysis For Discriminating Herbicide Site Of Action: A Novel Approach For Accelerating Herbicide Research, Zhongzhong Niu, Tanzeel Rehman, Julie Young, William G. Johnson, Takayuki Yokoo, Bryan Young, Jian Jin

Purdue University Libraries Open Access Publishing Fund

In agricultural weed management, herbicides are indispensable, yet innovation in their modes of action (MOA)—the general mechanisms affecting plant processes—has slowed. A finer classification within MOA is the site of action (SOA), the specific biochemical pathway in plants targeted by herbicides. The primary objectives of this study were to evaluate the efficacy of hyperspectral imaging in the early detection of herbicide stress and to assess its potential in accelerating the herbicide development process by identifying unique herbicide sites of action (SOA). Employing a novel SOA classification method, eight herbicides with unique SOAs were examined via an automated, high-throughput imaging system …

Qa-Snare Syntaxin 18 Mediates Lipid Droplet Fusion With Snap23 And Sec22b, Yuhui Fu, Binbin Ding, Xiaoxia Liu, Shangang Zhao, Fang Chen, Linsen Li, Yi Zhu, Jingxuan Zhao, Zhen Yuan, Yafeng Shen, Chaofeng Yang, Mengle Shao, She Chen, Perry E Bickel, Qing Zhong

Faculty, Staff and Students Publications

Lipid droplets (LDs) are dynamic lipid storage organelles that can sense and respond to changes in systemic energy balance. The size and number of LDs are controlled by complex and delicate mechanisms, among which, whether and which SNARE proteins mediate LD fusion, and the mechanisms governing this process remain poorly understood. Here we identified a SNARE complex, syntaxin 18 (STX18)-SNAP23-SEC22B, that is recruited to LDs to mediate LD fusion. STX18 targets LDs with its transmembrane domain spanning the phospholipid monolayer twice. STX18-SNAP23-SEC22B complex drives LD fusion in adiposome lipid mixing and content mixing in vitro assays. CIDEC/FSP27 directly binds STX18, …

Disruption Of Semiochemical-Mediated Movement By The Immature Trogoderma Variabile Baillon And Trogoderma Inclusum Le Conte (Coleoptera: Dermestidae) After Exposure To Long-Lasting Insecticide-Incorporated Netting, Sabita Ranabhat, Michael J. Domingue, Luke Lebar, Georgina Bingham, Kun Yan Zhu, William R. Morrison Iii

Department of Entomology: Faculty Publications

BACKGROUND: Highly mobile stored product insects may be able to readily orient in response to food cues and pheromones to attack durable commodities at each link of the postharvest supply chain. A 0.4% deltamethrin-incorporated long-lasting insecticide-incorporated netting (LLIN) is a successful novel preventative integrated pest management (IPM) tactic to intercept dispersing insects after harvest. However, it is unknown whether exposure to LLIN may affect olfaction and orientation to important semiochemicals by immature stored product dermestids, therefore the aim of this study was to assess whether exposure to LLIN disrupts the normal olfactory and chemotactic behavior of warehouse beetle, Trogoderma variabile …

Thriving With Oca, Dyanna Reynoso Aguirre, Hermela Shenkute

High Impact Practices Student Showcase Fall 2023

Working with OCA taught us how to work and help, people with special needs, more specifically children. Throughout our volunteering we helped kids at OCA with their arts and crafts, made sure they had their needs met and worked on building the skills when they were taught during their group sessions. We learned how to redirect their behaviors to something more positive, and we learned how to better communicate with kids who are nonverbal to make sure their needs are met.

Providing Access To Healthcare For The Uninsured Via Shepherd's Hope, Azeem Hakim

High Impact Practices Student Showcase Fall 2023

According to the U.S. Census Bureau in 2021, the population of uninsured individuals from the ages of zero to sixty-four in Orange County had a slight upward trend when compared to the two prior years, with roughly 182,054 uninsured patients living within Orange County in 2021. If so many of Orlando’s citizens in Orange County don’t have health insurance, and thus, are barred from being able to access quality healthcare, how could sustaining the vibrancy of our local community be possible, especially when many of these uninsured patients help keep the Orlando area functioning day to day? This is where …

Memory And Community Through Brain Wellness, Jack T. Gilbride, Joshua Borenstein, Eryn Proano, Ariah Todriff, Christopher Maraj

High Impact Practices Student Showcase Fall 2023

For our project we worked with a group called brain wellness in Oviedo. Their purpose is to provide fun brain enriching activities to older individuals suffering from dementia. We assisted in activities such as word matching games, rearranging popsicle sticks in order to make certain patterns that were displayed on a screen, and even card games like go fish. Some key things that we learned was how to address some issues that surround dementia such as trying to convince someone that they shouldn’t be driving at their age and not make that person feel upset. We also learned some more …

Navigating Sense Of Home: Migration Experiences Of Home And Community, Andrew Peter Camilleri

College of Science and Health Theses and Dissertations

Migrants experience significant stresses when transitioning to find a sense of belonging from one country to another (Kirmaryer et. al 2011), particularly when the nature of migration is forced. Language barriers, currency differences, different foods, written and unwritten rules of conduct as well as different climates all contribute to make the acculturative process difficult and stressful (Jackson & Bauder, 2014). Understanding how migrants navigate this process and the resources required to successfully integrate within a new host community is an important area of research both for migrants and the host communities.

Using an archival dataset collected by researchers from the …

The Dangerous Effect Of Entitlement On White Nationalist Ideology, Kara Elizabeth Harris

College of Science and Health Theses and Dissertations

Within the past few years, White nationalism has been on the rise due to societal changes and feelings of uncertainty for White Americans' perceptions of their racial group’s future. As a result, many have speculated what may be a factor in this rise. Previously it has been found that having a high White identity is associated with White nationalist ideologies. However, White identity may not be enough to drive White nationalist ideologies and the violence that can follow. Feelings of entitlement towards status, preferential treatment, and resources may contribute to White nationalist ideologies based on beliefs of superiority and deservedness …

Office Of Research, Economic Engagement And Outreach Update, November 21, 2023, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Antibody-Directed Evolution Reveals A Mechanism For Enhanced Neutralization At The Hiv-1 Fusion Peptide Site, Bailey B Banach, Sergei Pletnev, Adam S Olia, Kai Xu, Baoshan Zhang, Reda Rawi, Tatsiana Bylund, Nicole A Doria-Rose, Thuy Duong Nguyen, Ahmed S Fahad, Myungjin Lee, Bob C Lin, Tracy Liu, Mark K Louder, Bharat Madan, Krisha Mckee, Sijy O'Dell, Mallika Sastry, Arne Schön, Natalie Bui, Chen-Hsiang Shen, Jacy R Wolfe, Gwo-Yu Chuang, John R Mascola, Peter D Kwong, Brandon J Dekosky

Faculty, Staff and Student Publications

The HIV-1 fusion peptide (FP) represents a promising vaccine target, but global FP sequence diversity among circulating strains has limited anti-FP antibodies to ~60% neutralization breadth. Here we evolve the FP-targeting antibody VRC34.01 in vitro to enhance FP-neutralization using site saturation mutagenesis and yeast display. Successive rounds of directed evolution by iterative selection of antibodies for binding to resistant HIV-1 strains establish a variant, VRC34.01_mm28, as a best-in-class antibody with 10-fold enhanced potency compared to the template antibody and ~80% breadth on a cross-clade 208-strain neutralization panel. Structural analyses demonstrate that the improved paratope expands the FP binding groove to …

Silencing Of Genes By Promoter Hypermethylation Shapes Tumor Microenvironment And Resistance To Immunotherapy In Clear-Cell Renal Cell Carcinomas, Xiaofan Lu, Yann-Alexandre Vano, Xiaoping Su, Alexandra Helleux, Véronique Lindner, Roger Mouawad, Jean-Philippe Spano, Morgan Rouprêt, Eva Compérat, Virginie Verkarre, Cheng-Ming Sun, Mostefa Bennamoun, Hervé Lang, Philippe Barthelemy, Wenxuan Cheng, Li Xu, Irwin Davidson, Fangrong Yan, Wolf Hervé Fridman, Catherine Sautes-Fridman, Stéphane Oudard, Gabriel G Malouf

Faculty, Staff and Student Publications

The efficacy of immune checkpoint inhibitors varies in clear-cell renal cell carcinoma (ccRCC), with notable primary resistance among patients. Here, we integrate epigenetic (DNA methylation) and transcriptome data to identify a ccRCC subtype characterized by cancer-specific promoter hypermethylation and epigenetic silencing of Polycomb targets. We develop and validate an index of methylation-based epigenetic silencing (iMES) that predicts primary resistance to immune checkpoint inhibition (ICI) in the BIONIKK trial. High iMES is associated with VEGF pathway silencing, endothelial cell depletion, immune activation/suppression, EZH2 activation, BAP1/SETD2 deficiency, and resistance to ICI. Combination therapy with hypomethylating agents or tyrosine kinase inhibitors may benefit …

New Insights Into Yap/Taz-Tead-Mediated Gene Regulation And Biological Processes In Cancer, Yang Zhao, Marisela Sheldon, Yutong Sun, Li Ma

Faculty, Staff and Student Publications

The Hippo pathway is conserved across species. Key mammalian Hippo pathway kinases, including MST1/2 and LATS1/2, inhibit cellular growth by inactivating the TEAD coactivators, YAP, and TAZ. Extensive research has illuminated the roles of Hippo signaling in cancer, development, and regeneration. Notably, dysregulation of Hippo pathway components not only contributes to tumor growth and metastasis, but also renders tumors resistant to therapies. This review delves into recent research on YAP/TAZ-TEAD-mediated gene regulation and biological processes in cancer. We focus on several key areas: newly identified molecular patterns of YAP/TAZ activation, emerging mechanisms that contribute to metastasis and cancer therapy resistance, …

Clostridioides Difficile Spores Tolerate Disinfection With Sodium Hypochlorite Disinfectant And Remain Viable Within Surgical Scrubs And Gown Fabrics, Humaira Ahmed, Lovleen Tina Joshi

Peninsula Dental School

Clostridioides difficile is the most common cause of antibiotic-associated diarrhoea globally. Its spores have been implicated in the prevalence of C. difficile infection due to their resistance and transmission ability between surfaces. Currently, disinfectants such as chlorine-releasing agents (CRAs) and hydrogen peroxide are used to decontaminate and reduce the incidence of infections in clinical environments. Our previous research demonstrated the ability of C. difficile spores to survive exposure to recommended concentrations of sodium dichloroisocyanurate in liquid form and within personal protective fabrics such as surgical gowns; however, the present study examined the spore response to clinical in-use concentrations of sodium …

Safety And Efficacy Of Direct Oral Anticoagulants In Stroke Prevention In Patients With Atrial Fibrillation Complicated With Anemia And/Or Thrombocytopenia: A Retrospective Cohort Study, Wenlin Xu, Jiana Chen, Shuyi Wu, Nianxu Huang, Xia Chen, Wang Zhang, Wei Hu, Jun Su, Hengfen Dai, Ping Gu, Xiaohong Huang, Xiaoming Du, Ruijuan Li, Qiaowei Zheng, Xiangsheng Lin, Yanxia Zhang, Lang Zou, Yuxin Liu, Min Zhang, Xiumei Liu, Zhu Zhu, Jinhua Zhang

Faculty, Staff and Student Publications

BACKGROUND: There are limited data about the clinical benefits and harm of direct oral anticoagulants (DOACs) in stroke prevention in patients with atrial fibrillation (AF) complicated with anemia or thrombocytopenia.

METHODS: This is a multi-center retrospective cohort study involving 5469 AF patients from 15 hospitals in China. Patients were divided into three groups according to hemoglobin and platelet levels: Group 1 (hemoglobin male ≥ 130 g/L; female ≥ 120 g/L and platelet ≥ 100 × 10

RESULTS: Higher hemoglobin levels were associated with a reduced risk of total bleeding and major bleeding, while platelet counts were not associated with any …

Early And Empirical High-Dose Cryoprecipitate For Hemorrhage After Traumatic Injury: The Cryostat-2 Randomized Clinical Trial, Ross Davenport, Nicola Curry, Erin E Fox, Helen Thomas, Joanne Lucas, Amy Evans, Shaminie Shanmugaranjan, Rupa Sharma, Alison Deary, Antoinette Edwards, Laura Green, Charles E Wade, Jonathan R Benger, Bryan A Cotton, Simon J Stanworth, Karim Brohi, Cryostat-2 Principal Investigators

Faculty, Staff and Student Publications

IMPORTANCE: Critical bleeding is associated with a high mortality rate in patients with trauma. Hemorrhage is exacerbated by a complex derangement of coagulation, including an acute fibrinogen deficiency. Management is fibrinogen replacement with cryoprecipitate transfusions or fibrinogen concentrate, usually administered relatively late during hemorrhage.

OBJECTIVE: To assess whether survival could be improved by administering an early and empirical high dose of cryoprecipitate to all patients with trauma and bleeding that required activation of a major hemorrhage protocol.

DESIGN, SETTING, AND PARTICIPANTS: CRYOSTAT-2 was an interventional, randomized, open-label, parallel-group controlled, international, multicenter study. Patients were enrolled at 26 UK and US …

A Conceptual Framework For Nomenclatural Stability And Validity Of Medically Important Fungi: A Proposed Global Consensus Guideline For Fungal Name Changes Supported By Abp, Asm, Clsi, Ecmm, Escmid-Efisg, Eucast-Afst, Fdlc, Idsa, Isham, Mmsa, And Msgerc, Sybren De Hoog, Thomas J Walsh, Sarah A Ahmed, Ana Alastruey-Izquierdo, Barbara D Alexander, Maiken Cavling Arendrup, Esther Babady, Feng-Yan Bai, Joan-Miquel Balada-Llasat, Andrew Borman, Anuradha Chowdhary, Andrew Clark, Robert C Colgrove, Oliver A Cornely, Tanis C Dingle, Philippe J Dufresne, Jeff Fuller, Jean-Pierre Gangneux, Connie Gibas, Heather Glasgow, Yvonne Gräser, Jacques Guillot, Andreas H Groll, Gerhard Haase, Kimberly Hanson, Amanda Harrington, David L Hawksworth, Randall T Hayden, Martin Hoenigl, Vit Hubka, Kristie Johnson, Julianne V Kus, Ruoyu Li, Jacques F Meis, Michaela Lackner, Fanny Lanternier, Sixto M Leal, Francesca Lee, Shawn R Lockhart, Paul Luethy, Isabella Martin, Kyung J Kwon-Chung, Wieland Meyer, M Hong Nguyen, Luis Ostrosky-Zeichner, Elizabeth Palavecino, Preeti Pancholi, Peter G Pappas, Gary W Procop, Scott A Redhead, Daniel D Rhoads, Stefan Riedel, Bryan Stevens, Kaede Ota Sullivan, Paschalis Vergidis, Emmanuel Roilides, Amir Seyedmousavi, Lili Tao, Vania A Vicente, Roxana G Vitale, Qi-Ming Wang, Nancy L Wengenack, Lars Westblade, Nathan Wiederhold, Lewis White, Christina M Wojewoda, Sean X Zhang

Faculty, Staff and Student Publications

The rapid pace of name changes of medically important fungi is creating challenges for clinical laboratories and clinicians involved in patient care. We describe two sources of name change which have different drivers, at the species versus the genus level. Some suggestions are made here to reduce the number of name changes. We urge taxonomists to provide diagnostic markers of taxonomic novelties. Given the instability of phylogenetic trees due to variable taxon sampling, we advocate to maintain genera at the largest possible size. Reporting of identified species in complexes or series should where possible comprise both the name of the …

Butte Priority Soils Operable Unit (Bpsou) New And Mahoney Remedial Action Work Plan (Rawp) Request For Change, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Estimation Of Anthropogenic And Volcanic So2 Emissions From Satellite Data In The Presence Of Snow/Ice On The Ground, Vitali E. Fioletov, Chris A. Mclinden, Debora Griffin, Nickolay A. Krotkov, Can Li, Joanna Joiner, Nicolas Theys, Simon Carn

Michigan Tech Publications

Early versions of satellite nadir-viewing UV SO2 data products did not explicitly account for the effects of snow/ice on retrievals. Snow-covered terrain, with its high reflectance in the UV, typically enhances satellite sensitivity to boundary layer pollution. However, a significant fraction of high-quality cloud-free measurements over snow is currently excluded from analyses. This leads to increased uncertainties of satellite emission estimates and potential seasonal biases due to the lack of data in winter months for some high-latitudinal sources. In this study, we investigated how Ozone Monitoring Instrument (OMI) and TROPOspheric Monitoring Instrument (TROPOMI) satellite SO2 measurements over snow-covered surfaces can …

An External Validation Of The Kidney Donor Risk Index In The Uk Transplant Population In The Presence Of Semi-Competing Events, Stephanie Riley, K Tam, W-Y Tse, A Connor, Yinghui Wei

School of Engineering, Computing and Mathematics

Background Transplantation represents the optimal treatment for many patients with end-stage kidney disease. When a donor kidney is available to a waitlisted patient, clinicians responsible for the care of the potential recipient must make the decision to accept or decline the offer based upon complex and variable information about the donor, the recipient and the transplant process. A clinical prediction model may be able to support clinicians in their decision-making. The Kidney Donor Risk Index (KDRI) was developed in the United States to predict graft failure following kidney transplantation. The survival process following transplantation consists of semi-competing events where death …

Examining Quality, Use And Impact Of Psychotropic (Use) In Older Adults With Intellectual Disabilities (Equip): Study Protocol: Revised, Ashleigh Gorman, Marina Odalović, Philip Mccallion, Éilish Burke, Malcolm Maclachlan, Mary Mccarron, Martin Henman, Maeve Moran, Juliette O'Connell, Mike Walsh, Rohit Shankar, Máire O'Dwyer

Peninsula Medical School

Widespread, and sometimes inappropriate use of psychotropics in adults with intellectual disability has been an international concern. These medicines have been used to treat mental health conditions, but also, controversially, some types of behaviours not necessarily associated with the diagnosis or in the absence of a relevant diagnosis. Results from the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA) study of older adults with intellectual disability in Ireland revealed that 60% were taking psychotropics in 2010. In the intervening decade changes in regulations, policy, and increased decongregation of people with intellectual disability have taken place likely influencing …

Nutritional Management Of Dysgeusia In The Oncology Patient, Kara Wilson

Electronic Theses and Dissertations Archive

Background Dysgeusia is a side effect of chemoradiation that currently has no standard intervention. The findings of this study are intended to improve the understanding of how to best treat dysgeusia to contribute to the prevention of malnutrition and to improve quality of life in affected individuals. Objective This research aims to determine a need to establish best practices that can be applied in a standardized plan of care for nutritional management of dysgeusia in the adult oncology patient in order to prevent adverse outcomes and improve quality of life. Study Design Oncology registered dietitians in healthcare facilities across the …

Prospective Considerations For Suicide Preventative Dietetics Practice: A Narrative Review, William Charles Fite

Electronic Theses and Dissertations Archive

This narrative review draws connections between the scope of practice of Registered Dietitians and issues related to suicide risk. It covers literature on topics including nutrition science (divided into biomarkers, micronutrients, and microbiome), dietary pattern, food insecurity, eating disorders, and chronic illnesses. Articles were collected from three databases: PubMed, SCOPUS, and CINAHL Complete. They were then saved to a citation manager and screened, with additional screening being performed following export to Excel documents, with n = 61 being included. Altered lipid metabolism, thyroid markers, and fasting blood glucose may be associated with suicide risk. Diet composition, along with nutrient deficiencies, …

Examining Differential Item Functioning And The Factor Structure Of The Pediatric Symptom Checklist-17 Items Across Race, Family Income, Gender, Illness Duration, And Glycemic Health In Black And White Youth With Type 1 Diabetes, Alec Sisco

Electronic Theses and Dissertations Archive

Objective: The use of Item Response Theory (IRT) for measure development has increased in the mental health profession as IRT serves as the foundation for computerized adaptive tests (CAT). Components of IRT can be used to ensure equitable assessment across proxies of oppression on the latent construct through differential Item functioning (DIF) analyses. The focus of this study is the confirmation of the three-factor structure of the Pediatric Symptom Checklist 17 (PSC-17) and uniform and non-uniform DIF analysis of the PSC-17 items among youth living with Type 1 Diabetes (T1D), a population for which equitable and rapid assessment is essential. …