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Studi Potensi Senyawa Antioksidan Dari Kulit Jeruk Nipis (Citrus Aurantifolia) Secara In Silico, Rustaman Rustaman, Regaputra Satria Janitra, Annisyaban Fatiha Azzahra, Farhan Azhwin Maulana, Fauzian Giansyah Rohmatulloh, Wanda Destiarani, Ari Hardianto, Muhammad Yusuf, Iman Permana Maksum

Chimica et Natura Acta

Antioksidan merupakan senyawa yang dapat mencegah atau menghambat oksidasi molekul lain, yang pada makhluk hidup berperan dalam mempertahankan pertumbuhan dan metabolisme yang normal. Studi aktivitas antioksidan individual pada senyawa dari jeruk nipis telah dilakukan. Senyawa yang dipelajari difokuskan pada bergamottin, citropten dan asam klorogenat. Tujuan dari penelitian ini adalah mempelajari hubungan antara struktur molekul dengan aktivitas antioksidannya melalui perhitungan secara kimia komputasi potensial ionisasi, electrodonating power, dan net electrophilicity. Seluruh perhitungan dilakukan menggunakan program komputasi Gaussian 09 Revision D.01, pada level teori APFD/6-31+G(d) pada keadaan muatan netral (deprotonasi, negatif), positif (netral), dan negatif (negatif dua). Hasil yang diperoleh menunjukkan bahwa …

The Impact Of Blood Cupping (Al-Hijama) On Serum Creatinine And Uric Acid Levels In Patients From Hadhramout, Yemen, Saleh Bin Sumaidea, Hassan Pyar Ali Hassan, Adnan Ali Bakaduem, Abdulrahman Omar Almashjari, Abdullah Shamlan Bashumail, Mohammed Saeed Blhamed

Chimica et Natura Acta

Cupping is a wonderful healing tool that has been employed for hundreds of years by numerous traditional folklore practitioners. Cupping treats many diseases including eliminating blood pollutants like uric acid and creatinine. The aim of this study to evaluate the impact of cupping on blood pressure, uric acid concentration, and creatinine levels. Sixty (60) random patient between the ages of (20 -70) years were selected, the blood samples were collected before cupping and after cupping for the evaluation. The result showed that the levels of creatinine and uric acid decreased significantly (p < 0.05) after cupping for both creatinine and uric acid. Moreover, the study showed that blood pressure decreased significantly (p < 0.05) after cupping. The result concluded that cupping has positive impact on health by modulating creatinine, uric acid blood levels and decreasing blood pressure.

Biomarkers Of Affective Dysregulation Associated With In Utero Exposure To Etoh, Nune Darbinian, Nana Merabova, Gabriel Tatevosian, Mary Morrison, Armine Darbinyan, Huaqing Zhao, Laura Goetzl, Michael Edgar Selzer

Faculty, Staff and Student Publications

INTRODUCTION: Children with fetal alcohol spectrum disorders (FASD) exhibit behavioral and affective dysregulation, including hyperactivity and depression. The mechanisms are not known, but they could conceivably be due to postnatal social or environmental factors. However, we postulate that, more likely, the affective dysregulation is associated with the effects of EtOH exposure on the development of fetal serotonergic (5-HT) and/or dopaminergic (DA) pathways, i.e., pathways that in postnatal life are believed to regulate mood. Many women who use alcohol (ethanol, EtOH) during pregnancy suffer from depression and take selective serotonin reuptake inhibitors (SSRIs), which might influence these monoaminergic pathways in the …

Drivers Of Chronic Pathology Following Ischemic Stroke: A Descriptive Review, Grant W Goodman, Trang H Do, Chunfeng Tan, Rodney M Ritzel

Faculty, Staff and Student Publications

Stroke is the third leading cause of death and long-term disability in the world. Considered largely a disease of aging, its global economic and healthcare burden is expected to rise as more people survive into advanced age. With recent advances in acute stroke management, including the expansion of time windows for treatment with intravenous thrombolysis and mechanical thrombectomy, we are likely to see an increase in survival rates. It is therefore critically important to understand the complete pathophysiology of ischemic stroke, both in the acute and subacute stages and during the chronic phase in the months and years following an …

Pain Management By Chemogenetic Control Of Sensory Neurons, Yize Li, Xin Ge, Ru-Rong Ji

Faculty, Staff and Student Publications

In this study, Perez-Sanchez et al.1 developed a chemogenetic method aimed at alleviating pain in mouse models while dampening excitability in human sensory neurons. This analgesic effect was attained through the introduction of human α7 nicotinic acetylcholine receptor and glycine receptor pore domain via virus-mediated expression in sensory neurons, forming a chloride channel. The activation of this channel was made possible by specific agonists. This study highlights the potential for treating clinical pain by gene therapy.

Interlaboratory Comparison Of Pseudomonas Aeruginosa Phage Susceptibility Testing, Krupa Parmar, Lauren Komarow, Damon W Ellison, Andrey A Filippov, Mikeljon P Nikolich, Joseph R Fackler, Martin Lee, Anjna Nair, Priyesh Agrawal, Pranita D Tamma, Maria Souli, Scott R Evans, Kerryl E Greenwood-Quaintance, Scott A Cunningham, Robin Patel, Antibacterial Resistance Leadership Group

Faculty, Staff and Student Publications

Standardized approaches to phage susceptibility testing (PST) are essential to inform selection of phages for study in patients with bacterial infections. There is no reference standard for assessing bacterial susceptibility to phage. We compared agreement between PST performed at three centers: two centers using a liquid assay standardized between the sites with the third, a plaque assay. Four Pseudomonas aeruginosa phages: PaWRA01ø11 (EPa11), PaWRA01ø39 (EPa39), PaWRA02ø83 (EPa83), PaWRA02ø87 (EPa87), and a cocktail of all four phages were tested against 145 P. aeruginosa isolates. Comparisons were made within measurements at the two sites performing the liquid assay and between these …

Neuromuscular Basis Of Drosophila Larval Rolling Escape Behavior, Patricia C Cooney, Yuhan Huang, Wenze Li, Dulanjana M Perera, Richard Hormigo, Tanya Tabachnik, Isuru S Godage, Elizabeth M C Hillman, Wesley B Grueber, Aref A Zarin

Faculty, Staff and Student Publications

To escape from dangerous stimuli, animals execute escape behaviors that are fundamentally different from normal locomotion. The rolling escape behavior of Drosophila larvae consists of C-shaped bending and rolling. However, the muscle contraction patterns that lead to rolling are poorly understood. We find that following the initial body bending, muscles contract in a circumferential wave around the larva as they enter the bend, maintaining unidirectional rolling that resembles a cylinder rolling on a surface. We study the structure of motor circuits for rolling, inhibit different motor neurons to determine which muscles are essential for rolling, and propose circuit and biomechanical …

Mgmt Function Determines The Differential Response Of Atr Inhibitors With Dna-Damaging Agents In Glioma Stem Cells For Gbm Therapy, Vincent W S Leong, Sabbir Khan, Pratibha Sharma, Shaofang Wu, Riya R Thomas, Xiaolong Li, Sanjay K Singh, Frederick F Lang, Alfred W K Yung, Dimpy Koul

Faculty, Staff and Student Publications

BACKGROUND: The most prevalent cancer treatments cause cell death through DNA damage. However, DNA damage response (DDR) repair pathways, initiated by tumor cells, can withstand the effects of anticancer drugs, providing justification for combining DDR inhibitors with DNA-damaging anticancer treatments.

METHODS: Cell viability assays were performed with CellTiter-Glo assay. DNA damage was evaluated using Western blotting analysis. RNA-seq and single-cell level expression were used to identify the DDR signatures. In vivo, studies were conducted in mice to determine the effect of ATris on TMZ sensitization.

RESULTS: We found a subpopulation of glioma sphere-forming cells (GSCs) with substantial synergism with temozolomide …

Interleukin-17-Mediated Protective Cytokine Signaling Against Degeneration Of The Retinal Pigment Epithelium, Yan Chen, Sarah E Bounds, Xiang Ma, James Regun Karmoker, Yin Liu, Jian-Xing Ma, Jiyang Cai

Faculty, Staff and Student Publications

Injuries to the retinal pigment epithelium (RPE) and outer retina often result in the accumulation of retinal microglia within the subretinal space. These subretinal microglia play crucial roles in inflammation and resolution, but the mechanisms governing their functions are still largely unknown. Our previous research highlighted the protective functions of choroidal γδ T cells in response to RPE injury. In the current study, we employed single-cell RNA sequencing approach to characterize the profiles of immune cells in mouse choroid. We found that γδ T cells were the primary producer of interleukin-17 (IL-17) in the choroid. IL-17 signaled through its receptor …

Coveting Relationships Over Association: The Church's Response To The Millennial's Exodus, Erik W. Switzer

Doctoral Dissertations and Projects

This project identified the reasons church-affiliated millennials in Tyler, Texas, have exited the church after reaching adulthood and have failed to return in significant numbers. To capture the reasons for this generational church exodus, area millennials were invited to participate in an anonymous online survey. To participate in the survey, millennials must have regularly attended an Evangelical or Catholic church during childhood and adolescence and stopped attending church after age eighteen. The survey invitation was distributed through emails and the social media platform Facebook. The invitation contained an embedded hyperlink that directed participants to Survey Monkey. All survey results reside …

Healing Artists Through Art, Corey Aaron Cundiff

Masters Theses

Men die by suicide nearly four times more than women, with higher rates among artists. There has been an increase in the rate of suicide over the years, primarily linked to depression and mounting societal expectations imposed upon men. The prevalence of social media and the awareness that comes with indicates that the issue of suicide may never disappear unless action is taken. This paper examines the need for art therapy to counter depression among male artists. No longer do we need to rely strictly on medication and talk therapy to treat depression. Many art therapy techniques have proven quite …

Extending Public Accessibility To The Mind: Designing Airports For People With Aphasia, Savannah Eloise Garzon

Masters Theses

Imagine traveling in an airport in another country. The language is entirely foreign, and all signs are written in text you cannot understand. You have ten minutes to make your connection. How do you find your gate? How do you ask questions? This hypothetical generation of panic is the reality for many travelers every day who suffer from aphasia. Aphasia is a language disorder often caused by stroke or other brain injury that makes it difficult to communicate, read, and process numbers, especially in stressful environments like an airport. More than two million people in America suffer from aphasia and …

Beyond Sunday Morning: Communal Singing And Corporate Identity, Justin Aaron Mckinney

Doctoral Dissertations and Projects

Corporate worship singing long aided congregants in growing their communal identity and theological understanding of biblical principles. While modern singing trends help congregants grow their theological understanding, modern church singing trends suggest songs are not encouraging growth in communal identity mimicking cultural values of individualism in corporate worship song lyrics. Historically, individual first-person pronouns represented the individuals alongside the rest of the church; but with a rise in cultural individualism, first-person pronouns now represent individuals independent of one another. This individualistic focus can lead congregants to conclude they do not need the church and to remove themselves from the body …

The Impact Of The Covid-19 Pandemic For High School Counselors: A Phenomenological Investigation, Melissa Ann Jensen

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to discover the comprehensive effect that the COVID-19 pandemic had and may still be having on high school counselors in the Houston metropolitan area. Maslow’s Hierarchy of Needs theory guides this study as it notes an individual’s ability to advance toward self-actualization in one’s personal and professional life. The COVID-19 pandemic altered one’s ability to accomplish those steps. Interviews with high school counselors assisted in gathering personal experiences as to how much the COVID-19 pandemic impacted their ability to become their best selves, both personally and professionally. Two focus groups were conducted to …

The Salvation Testimony Of African-American Converts In The Protestant Faith: A Phenomenological Study, Tenielle Jones Cook

Doctoral Dissertations and Projects

Humanity's frailty and mortal existence create the space for a spiritual conversion experience that resolves matters of life and death. However, spirituality is an abstract concept with an ambiguous definition, and activities surrounding the application of its concepts are interpreted differently from one religious group or community to the next. The purpose of this phenomenological study was to explore the salvation testimony of African-American males and females in the Protestant faith. A semi-structured interview and Conversation analysis are used for data collection and analysis to identify emerging themes for the descriptive essence of the salvation testimony. At this stage in …

A College Outreach Initiative To Connect Paine College Students With Thankful Baptist Church, Christopher J. Waters

Doctoral Dissertations and Projects

College students’ declining attendance and participation at Thankful Baptist Church is a growing concern for the congregation and its leadership. For over one hundred years the church has had a strong outreach to the students at Paine College, a local HBCU and private Christian institution. However, over the last five years Thankful Baptist Church’s outreach to Paine College students has declined significantly. This research project implemented training for ten outreach volunteers and six weeks of mentoring for ten Paine College students to revive the declined college ministry to Paine College into an active ministry which attracts and retains college students …

Exploring The Lived Experiences Of Graduate School Students On Developing Human Capital Through Family Life Education And Leadership Development, Francis Ngulefac

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to explore the lived experiences of graduate school students on developing human capital through family life education and leadership development in the Washington, DC Metropolitan Area. The theory that informed this study is the human capital theory, which postulates that human beings can improve upon their productive capacity by pursuing further education and acquiring more work-related skills and experience. Thus, this study explored the lived experiences of graduate school students in the Washington, DC Metropolitan Area concerning this theory. I recruited 12 graduate school students living in the Washington, DC Metropolitan Area in …

The Impact Of Effective Teaching In Closing The Achievement Gap For Minority Students Entering Post-Secondary Education: A Case Study, Diamon Cymon Ike Hughes

Doctoral Dissertations and Projects

The purpose of this instrumental case study was to explore the practices and strategies utilized by high-performing teachers to impact the learning outcomes for economically disadvantaged and minority students. The theory driving this study was Hattie’s theory of visible learning, which asserts that teaching and learning are the most significant factors impacting student achievement. The study took place at Phoenix Academy Alternative High School. Phoenix is an alternative high school for at-risk students and is a majority economically disadvantaged and minority campus. Participants in the study were teachers who teach core subjects with mandatory passing requirements for student graduation and …

Understanding Lived Experiences Of Correctional Officers' Reintegration Back Into The Work Environment Post-Assault, Claudette Duggins

Doctoral Dissertations and Projects

The researcher explored the experiences of correctional officers assaulted by inmates, focusing on the impact of such assaults on their reintegration into the work environment. The researcher sought to understand how these experiences affect officers' attitudes, behaviors, and decision-making, which could impact the safety and security of the institution and the public. A qualitative approach using a phenomenological research design was employed to understand the lived experiences of assaulted correctional officers. Data emerged through participant interactions, capturing their personal experiences and perspectives. The qualitative method was chosen over a quantitative approach as it allowed for an in-depth understanding of the …

A Phenomenological Study Of The Effects Of Unresolved Sexual Trauma On Intimacy In African American Women Relationships, Gianna Latrice Jackson

Doctoral Dissertations and Projects

Childhood sexual abuse (CSA) has multifaceted effects on survivors. The psychological distress stemming from CSA often leads to the development of abnormal cognitions and behaviors that persist throughout a survivor's lifetime. While substantial research has focused on the long-term consequences for women who have experienced childhood sexual assault, there is still a need to explore the experiences of African American (AA) women who have encountered CSA and how it shapes their ability to engage in intimate sexual relationships. This phenomenological study aims to investigate the lived experiences of AA women who have endured CSA, with a particular focus on the …

The Impact Of Shame On Medication-Assisted Therapy Treatment Outcomes For Individuals With A Severe Opiate Use Disorder, Cameron Davis Mcclure

Doctoral Dissertations and Projects

Shame has a significant impact on various psychopathologies including depression (Pinto et al., 2012), anxiety, and posttraumatic stress disorder (Bryan et al., 2013). The gap in this research is the quantitative impact of shame on the relapse cycle in individuals with a severe opioid use disorder. This research study will demonstrate the impact of shame on the expression of addictive behavior in patients that have a diagnosed opiate use disorder and are currently actively enrolled in a medication-assisted therapy treatment program. This research study will illustrate how the presence of increased therapeutic alliance strength can result in the reduction of …

The Effectiveness Of K-12 Online Music Education During The Covid-19 Lockdown, Christopher Lafser

Doctoral Dissertations and Projects

Despite the successes of online education, students often learn and develop skills in classroom music ensembles that cannot be replicated in online learning. Virtual learning is a new tool for some educators and during the 2020-2022 COVID-19 Pandemic lockdown, many schools were not prepared for the sudden changes the lockdowns needed. Since the lockdown, there have been few studies which examine student music engagement in 100% virtual learning as compared to in-classroom instruction. This qualitative research study examines in what ways music students engage in 100% virtual learning compared to students in a traditional classroom in the areas of musical …

The Necessity Of Spiritual Preparation In Short-Term Missions As It Correlates To Ministry Effectiveness, Brent Edward Allen

Doctoral Dissertations and Projects

There is a lack of resources available providing spiritual preparation training specifically for teams preparing for a STM with M4 Institute. The purpose of this action research project is two-fold. First, to develop a spiritual preparation resource for STM work in the Western Highlands of Guatemala. Second, to determine if providing spiritual preparation training for a team preparing for said STM work will improve the ministry effectiveness of the trip. An eight-week, five-phase intervention guide was created to implement with the focus group. This consisted of two in-person, on-site team trainings, three pre-trip Zoom team meetings, mid-trip communications with participants …

A Phenomenological Study Exploring An Infertile Christian Woman's Experience From Clergy Counseling In A Local Church, Laura Lasek

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to discover the perceptions of infertile women’s perceived experiences with receiving counseling from their local church pastor. The theories guiding this study were identity theory and narrative identity theory, as an infertile woman often feels a loss in their identity due to not being able to become a mother. This study explored how an infertile woman had hope to identify as a mother perceived counseling from her local church. The central research question for this transcendental phenomenological study was: How does a Christian woman who is coping with infertility describe the impact of …

Retaining Students After Graduation With Biblical Servanthood, Carlos Henrique De Freitas

Doctoral Dissertations and Projects

This thesis addresses the inadequate understanding of the biblical concept of servanthood among high school students (grades 9-12) within the congregation of Macland Baptist Church in Powder Springs, Georgia. As a result of this problem, students gradually distance themselves from their faith, discontinue church attendance, and cease participating in church service activities. The thesis of this paper is that exposing these high school students to various dimensions of biblical servanthood will significantly impact their understanding of this concept. The underlying assumption posits that a profound understanding of biblical servanthood, coupled with knowledge and service opportunities, will cultivate Christlike character in …

Exploring The Need For Additional Title Ix Education And Training, Maria K. Lamiotte

Doctoral Dissertations and Projects

This quantitative study explores the differences between students, faculty, and staff about the need for additional Title IX education and training at a community college in Southeastern Connecticut from the four-level construct of the Social-Ecological Model of sexual misconduct prevention. This paper analyzed the existing literature on sexual misconduct education and training across higher education institutions, specifically related to community colleges nationwide. The literature was limited, related to community colleges. The data analysis explored the differences between students, faculty, and staff’s gender, sexual orientation, and college status about the need for additional Title IX education and training using archival data …

Worship And The Generational Divide: A Study Of Inclusive Worship In The Church, Willie S. Moody

Doctoral Dissertations and Projects

Every generation has a different way of engaging in congregational worship, sometimes at odds with another generation. The current challenge for pastors and worship leaders of churches with multiple generations is planning worship services that consider the congregation's complex make-up and remain faithful to the principles of biblical worship. The purpose of this qualitative research project is to provide a worship model that facilitates the worship styles and preferences of multiple generations within a church congregation. An atmosphere of worship is desired for all persons attending weekly worship services whose hearts and minds are receptive to the move of God …

A Quantitative Study On The Impact Of Covid-19 On Drug Treatment Courts, Derek J. Kingsbury

Doctoral Dissertations and Projects

The purpose of this research study was to investigate how the COVID-19 pandemic impacted drug treatment courts (DTCs) in Pennsylvania. DTCs were created as an alternative to the traditional court system by allowing those convicted of a drug offense to receive treatment. Just as these DTCs were dealing with the opioid crisis, a new obstacle occurred in the form of the COVID-19 pandemic, forcing DTCs to adapt to the quickly evolving and changing mandates and policies implemented by the federal and local governments. The impact of the COVID-19 pandemic on these essential DTCs was examined using a therapeutic jurisprudence perspective. …

Forgiveness In Education: A Qualitative Analysis Of The Forgiveness Experience For Educators, Corinne D. Denhartog

Doctoral Dissertations and Projects

Forgiveness is as powerful as it is complex. Evaluating how teachers understand and practice forgiveness has potential applications within broader forgiveness theory as well as more practically in discussions of both teacher health related to practicing forgiveness and student learning of forgiveness. The present study sought to gather qualitative insights related to teacher understanding of forgiveness, teacher practice of forgiveness within their jobs, and teacher opinions on forgiveness education. A total of six semi-structured focus group interviews were conducted with groups of two to four public school teachers. Results indicated that there is variety in understanding amongst teachers of what …

Using Mindfulness In Nursing Burnout. An Integrative Review., April Day Branham

Doctoral Dissertations and Projects

The purpose of this integrative review is to evaluate if mindfulness is effective in decreasing nursing burnout. Nursing burnout has negatively affected the nursing profession for many years, and since the COVID-19 pandemic, it appears to be worse. Mindfulness is a practice that has been used for decades, however, it is gaining more attention in the nursing realm. Mindfulness consists of being present in a moment without judgment. It can consist of individual exercises that are completed using an instructor in person, in an application on a smartphone or computer, or yoga-based mindful activities. A preliminary literature review was completed …