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December 19, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

A Quantum Physics-Based Force Field For Biomolecular Simulation, Roseane Dos Reis Silva

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation explores the development of a physics-based force field meticulously tailored to guide molecular dynamics simulations of biomolecules. At its core, the Hydrogen-like Intermolecular Polarizable Potential (HIPPO) force field emerges as an apex of achievement, devised to refine the precision of short-range intermolecular interactions. HIPPO's inception marks a profound stride towards heightened realism in molecular simulations, anchored in Quantum Physics theory and fortified by state-of-the-art Quantum Chemistry calculations. This force field's efficacy is attested by its systematic application in constructing models featuring diverse organic molecules, from water to benzene, and those with motifs resembling proteins and nucleic acids. HIPPO …

The Federal Government Must Revise Public Housing Policies To Protect Vulnerable Populations From Evictions, Caroline Grabowski

Population Health Research Brief Series

Over 100,000 Americans are now dying from drug overdoses annually, signifying that the goal of the 1986 Anti-Drug Abuse Act (ADAA) to end illicit drug use has not been achieved. What’s more, numerous statutes within the ADAA have created or worsened housing instability among people who use drugs and their families. This is because the ADAA allows public housing officials to use their own discretion when determining evictions and lease refusals and has disproportionately harmed individuals in public housing who did not participate in the drug-related activities that led to their eviction. This brief describes how the ADAA negatively affects …

The Pharmacological Deprescription In Elderly Patients, Chelsey Ali, Daniel Huang, Charlene Tugwete, Stefano Del Canale, Vittorio Maio

College of Population Health Faculty Papers

No abstract provided.

Investigating The Relationship Between Smoking, Genomics, And Brain Imaging, Yoonhoo Chang

Arts & Sciences Graduate Student Theses and Dissertations

Cigarette smoking has been linked to adverse health outcomes, including several forms of cancer, respiratory and cardiovascular disease, and dementia. Despite the public health campaigns aimed at reducing tobacco use, the behavior remains prevalent, and its association with various organs is an active area of research. Recent studies showed that smoking behaviors have strong genetic contributions. Through genome-wide association studies, the genetic risk score of individuals can be created and used as a basis for more effective and precise healthcare solutions. Chapter 2 explores the creation of a polygenic risk score (PRS) for smoking cessation and its utility in two …

Regulatory Managerialism And Inaction: A Case Study Of Bank Regulation And Climate Change, Hilary J. Allen

Law and Contemporary Problems

No abstract provided.

With Regard For Persons, William Boyd

Law and Contemporary Problems

No abstract provided.

Integrated Detection Scheme For Fast Blood Flow Measurement, Ashwin Bharadwaj Parthasarathy, Arindam Biswas, Arash Takshi

USF Patents

Disclosed are various embodiments for integrated diffuse correlation spectroscopy. A first control signal can be sent to a switch to cause an integrator to integrate a current from a photodiode. An integrated current can be received from the integrator, and a data signal can be sent to a computing device based at least in part on the integrated current. A second control signal can be sent to a switch to cause the integrator to cease integrating the current from the photodiode.

Pkc-Delta-I Inhibitor Formulations And Uses Thereof, Niketa A. Patel, Rekha S. Patel, Robert Pleasants Sparks, Wayne Charles Guida

USF Patents

Provided herein are formulations that can contain an effective amount of a PKCδ inhibitor. Also provided herein are methods of inhibiting a PKCδ in a subject in need thereof, that can include the step of administering an effective amount of a compound that is capable of inhibiting a PKCδ.

Best Practices For Serving Lbgtq+ Students In The 21st Century: A Systematic Literature Review, Mary Elizabeth Turner

Library Faculty Publications

To best serve LGBTQ+ students in an academic library, it is necessary to develop a list of best practices. While there is ample literature on the topic of the needs of LGBTQ+ students in academic libraries and how to address those needs, there is no readily accessible list of evidence-based best practices for general implementation. To address this need, the author identified an initial pool of 210 articles published in library journals between 2000 and 2022. Of those 210 articles, 109 articles met all conditions for further review. A total of 21 articles within the review pool contained specific recommendations …

Synthesis, Characterization, And Bslt Test Of Pyrazoline And Pyrazole Compounds From Chalcone Using Microwave Irradiation, Siska Elisahbet Sinaga, Matius Paundanan, Yum Eryanti

Chimica et Natura Acta

Pyrazole is an organic compound, classified as an alkaloid, featuring a heterocyclic five-membered ring structure composed of three carbon atoms and two adjacent nitrogen atoms, forming an endocyclic double bond. Pyrazole has various biological activities, such as antibacterial, anticanc er, antiinflammatory, antidepressantion, and antioxidant. Pyrazole 2-(5-(4-chlorophenil)-1-phenil-1H-pyrazole-3il)phenol (TFP-2OH-4Cl) was synthesized via oxidative aromatization reaction of pyrazoline 2-(5-(4-chlorophenil)-1-phenil-4,5-dihydro-1H-pyrazole-3-il)phenol (PF-2OH-4Cl) with glacial acetic acid. Chalcone, pyrazoline, and pyrazole were synthesized using the microwave at 180 W at 85oC. The purity of the compounds was monitored on TLC plates, melting point, and HPLC analysis. The structure of synthesized compounds was confirmed by UV, FTIR, …

Tempe Kedelai Hitam (Glycine Soja) Dan Kacang Buncis Putih (Phaseolus Vulgaris L.) Sebagai Pangan Fungsional Antioksidan, Sri Yadial Chalid, Anna Muawanah, Nani Radiastuti, Sofia Ade Putri, Fitriah Hartiningsih, Tarso Rudiana

Chimica et Natura Acta

Kedelai hitam dan biji kacang buncis mengandung senyawa flavonoid dan fenolik yang berpotensi dikembangkan sebagai pangan fungsional antioksidan. Campuran kedelai hitam dan biji kacang buncis putih 1:1 difermentasi dengan ragi tempe 0,2% (b/b) dan angkak divariasikan sebesar 1; 1,5; 2% (b/b) dengan waktu fermentasi 0, 12, dan 24 jam. Jumlah angkak dan waktu fermentasi optimum ditentukan berdasarkan karakteristik tempe dari uji organoleptik meliputi warna, bau, dan tekstur tempe oleh 25 orang panelis. Tempe diekstrak menggunakan aseton 80% (v/v) dan diukur aktivitas antioksidan dengan metode 2,2-diphenyl-1-picryhydrazyl (DPPH) serta total fenolik dan total flavonoid. Hasil uji organoleptik menunjukkan bahwa fermentasi selama 24 …

Overview Of Urinary Tract Infection Caused By Bacteria, Ahmed Talib Abdulkarem, Shaimaa M.S. Zainulabdeen, Saif Mazeel Abed

Muthanna Medical Journal

Urinary tract infections [UTIs], a significant public health concern, can be brought on by a wide variety of bacteria, including Escherichia coli, Proteus mirabilis, Enterococcus faecalis, Klebsiella pneumoniae, and Staphylococcus saprophyticus. The high recurrence rates and evolving antibiotic resistance of uropathogens constitute a serious threat to the financial burden of these disorders. Pathogens in urine can be detected using a variety of diagnostic approaches, which are broadly divided into laboratory-based and point-of-care [POC] detection methods. Many research institutions and companies working in this subject have strived to establish a rapid and accurate pathogen identification because traditional approaches may be time-consuming. …

Traffic Congestion Analysis Using Sir Epidemic Model, Zani Anjani Rafsanjani, Ratna Herdiana, R Heru Tjahjana, Yogi Ahmad Erlangga

All Works

In this work, we propose a mathematical model to represent traffic congestion in the street under some consideration. A congestion problem in a city highway becomes a critical issue since congestion at one point affected congestion propagation on the other points. We focus on the propagation of traffic propagation by adopting the concept of disease spread using the SIR model. We consider that the disease in traffic problems is congestion. Meanwhile, vehicles that enter the highway are susceptible to congestion. In contrast, vehicles free from traffic jams represent individuals free from disease. The SIR model can explain the spread of …

The 50 Most Cited Papers On Rugby Since 2000 Reveal A Focus Primarily On Strength And Conditioning In Elite Male Players, Katherine J. Hunzinger, Eric Schussler

Department of Exercise Science Faculty Papers

We sought to conduct a bibliometric analysis and review of the most cited publications relating to rugby since 2000 in order to identify topics of interest and those that warrant further investigations. Clarivate Web of Science database was used to perform a literature search using the search term "rugby." The top 200 papers by citation count were extracted and reviewed for the inclusion criteria: all subjects were rugby players. The top 50 manuscripts were included for analysis of author, publication year, country of lead authors, institution, journal name and impact factor, topic, participant sex, and level of rugby. The total …

A Large-Scale Experiment Finds No Consistent Evidence Of Change In Mortality Or Commercial Productivity In Silverlip Pearl Oysters (Pinctada Maxima) Exposed To A Seismic Source Survey, Miles J G Parsons, Diego R. Barneche, Conrad W. Speed, Robert D. Mccauley, Ryan D. Day, Cecile Dang, Rebecca Fisher, Hosna Gholipour-Kanani, Stephen J. Newman

Fisheries Research Articles

High-intensity, impulsive sounds are used to locate oil and gas reserves during seismic exploration of the seafloor. The impacts of this noise pollution on the health and mortality of marine invertebrates are not well known, including the silverlip pearl oyster (Pinctada maxima), which comprises one of the world's last remaining significant wildstock pearl oyster fisheries, in northwestern Australia. We exposed ≈11,000 P. maxima to a four-day experimental seismic survey, plus one vessel-control day. After exposure, survival rates were monitored throughout a full two-year production cycle, and the number and quality of pearls produced at harvest were assessed. Oysters from two …

Nurturing Sustainable Careers: How New India’S Nep 2020 Is Driving Employability Through Skills-Based Education, Sadhna Dash, Ramakanth Tallapragada, Elizabeth Abba

Journal of Management for Global Sustainability

As New India prepares to become a “developed” country by the year 2047, the strategies for managing one of the most populous economies in the world are undergoing steady and positive transformation. The country’s new National Education Policy (NEP) 2020 has set the context for enhanced employability for the masses and sustainable careers, potentially transforming the youngest workforce in the world not only by equipping them with the skills, knowledge, and abilities that the workplace demands but also by providing opportunities for inclusive, sustainable, and trans-disciplinary employment. However, given that the NEP 2020 will not succeed as a standalone initiative, …

20231219_Library Renovation Project Begins, Sally Bowler-Hill

HSLIC Blog Post

No abstract provided.

Improving The Quality Of Micronutrient Food Composition Data In Sub-Saharan Africa Using Predictive Analytics, Junior Mbuyamba Muka

Theses and Dissertations

High-quality food composition data are indispensable for decision making in several health, agricultural, and nutrition-related activities. Analytical data are the most accurate type of food composition data (FCD). Yet, most food composition databases (FCDBs) compiled in Sub-Saharan Africa only contain a small amount of analytical data collected from foods consumed in this region. Most of the data are either borrowed / copied from FCDBs collected in other parts of the world, calculated, imputed, or presumed data. Even with these alternative types, FCDBs in Sub-Saharan Africa have not reached a satisfactory level of completeness, as they still have missing data for …

Intragenic Egfr::Egfre1e8 Fusion (Egfrviii) In 4331 Solid Tumors, Lan Zheng, Rajyalakshmi Luthra, Hector A Alvarez, F Anthony San Lucas, Dzifa Y Duose, Ignacio I Wistuba, Gregory N Fuller, Leomar Y Ballester, Sinchita Roy-Chowdhuri, Keith J Sweeney, Asif Rashid, Richard K Yang, Wei Chen, Audrey Liu, Yun Wu, Constance Albarracin, Keyur P Patel, Mark J Routbort, Aysegul A Sahin, Qingqing Ding, Hui Chen

Faculty, Staff and Student Publications

Epidermal growth factor receptor variant III (EGFRvIII, the deletion of exons 2-7) is a recurrent intragenic EGFR::EGFR.E1E8 fusion that occurs in high-grade gliomas. The presence of EGFRvIII in other solid tumors has not been well characterized. We retrospectively reviewed advanced malignant solid tumor cases tested by a custom hybrid capture 610-gene next-generation sequencing platform from 2021 to 2022. EGFRvIII was identified in 17 of 4331 (0.4%) cases, including 16 of 238 (7%) brain tumors and 1/301 (0.3%) breast tumors. EGFRvIII-positive brain tumors were all glioblastoma IDH-wildtype, most with concurrent TERT promoter mutation (14 of 16), EGFR amplification (13 of …

Blue-Shift Photoconversion Of Near-Infrared Fluorescent Proteins For Labeling And Tracking In Living Cells And Organisms, Francesca Pennacchietti, Jonatan Alvelid, Rodrigo A Morales, Martina Damenti, Dirk Ollech, Olena S Oliinyk, Daria M Shcherbakova, Eduardo J Villablanca, Vladislav V Verkhusha, Ilaria Testa

Faculty, Staff and Student Publications

Photolabeling of intracellular molecules is an invaluable approach to studying various dynamic processes in living cells with high spatiotemporal precision. Among fluorescent proteins, photoconvertible mechanisms and their products are in the visible spectrum (400-650 nm), limiting their in vivo and multiplexed applications. Here we report the phenomenon of near-infrared to far-red photoconversion in the miRFP family of near infrared fluorescent proteins engineered from bacterial phytochromes. This photoconversion is induced by near-infrared light through a non-linear process, further allowing optical sectioning. Photoconverted miRFP species emit fluorescence at 650 nm enabling photolabeling entirely performed in the near-infrared range. We use miRFPs as …

Extended-Synaptotagmin-1 And -2 Control T Cell Signaling And Function, Nathalia Benavides, Claudio G. Giraudo

Department of Microbiology and Immunology Faculty Papers

Upon T-cell activation, the levels of the secondary messenger diacylglycerol (DAG) at the plasma membrane need to be controlled to ensure appropriate T-cell receptor signaling and T-cell functions. Extended-Synaptotagmins (E-Syts) are a family of inter-organelle lipid transport proteins that bridge the endoplasmic reticulum and the plasma membrane. In this study, we identify a novel regulatory mechanism of DAG-mediated signaling for T-cell effector functions based on E-Syt proteins. We demonstrate that E-Syts downmodulate T-cell receptor signaling, T-cell-mediated cytotoxicity, degranulation, and cytokine production by reducing plasma membrane levels of DAG. Mechanistically, E-Syt2 predominantly modulates DAG levels at the plasma membrane in resting-state …

Regulatory Managerialism As Gaslighting Government, Jodi L. Short

Law and Contemporary Problems

No abstract provided.

Power And Knowledge In Policy Evaluation: From Managing Budgets To Analyzing Scenarios, Frank Pasquale

Law and Contemporary Problems

No abstract provided.

The Anti-Managerial Information Commission, Margaret B. Kwoka

Law and Contemporary Problems

No abstract provided.

A Public Technology Option, Hannah Bloch-Wehba

Law and Contemporary Problems

No abstract provided.

Introduction: Framing Regulatory Managerialism As An Object Of Study And Strategic Displacement, Julile E. Cohen, Ari Ezra Waldman

Law and Contemporary Problems

No abstract provided.

Needle Biopsy Accelerates Pro-Metastatic Changes And Systemic Dissemination In Breast Cancer: Implications For Mortality By Surgery Delay, Hiroyasu Kameyama, Priya Dondapati, Reese Simmons, Macall Leslie, John Langenheim, Yunguang Sun, Misung Yi, Aubrey Rottschaefer, Rashmi Pathak, Shreya Nuguri, Kar-Ming Fung, Shirng-Wern Tsaih, Inna Chervoneva, Hallgeir Rui, Takemi Tanaka

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

ncreased breast cancer (BC) mortality risk posed by delayed surgical resection of tumor after diagnosis is a growing concern, yet the underlying mechanisms remain unknown. Our cohort analyses of early-stage BC patients reveal the emergence of a significantly rising mortality risk when the biopsy-to-surgery interval was extended beyond 53 days. Additionally, histology of post-biopsy tumors shows prolonged retention of a metastasis-permissive wound stroma dominated by M2-like macrophages capable of promoting cancer cell epithelial-to-mesenchymal transition and angiogenesis. We show that needle biopsy promotes systemic dissemination of cancer cells through a mechanism of sustained activation of the COX-2/PGE₂/EP2 feedforward loop, …

Global Partnerships In Transformation Of Nursing And Midwifery Education In Africa: A Systematic Scoping Review Protocol, Claudine Muraraneza, Donatilla Mukamana, Godfrey Katende, Oliva Bazirete, Liz Wolvaardt

School of Nursing & Midwifery, East Africa

Background In recent decades, the literature on global partnerships in nursing and midwifery education, for the purpose of enhancing quality of education, strengthening health care system, and achieving universal health coverage is on the rise in Africa. However, there is a gap regarding the best practices and barriers in the African context. The purpose of this systematic scoping review is to map the evidence on global partnerships in transforming nursing and midwifery education in Africa.

Methods A search will be conducted with the use of the following electronic databases: Cumulative Index to Nursing and Applied Health Literature [CINAHL], PubMed, Cochrane …

Perbandingan Kadar Magnesium Pada Air Minum Dalam Kemasan (Amdk) Menggunakan Metode Spektrofotometri Dan Kompleksometri, Edy Agustian Yazid, Abdul Wafi, Roihatul Zahroh, Nurul Azizah

Chimica et Natura Acta

Magnesium (Mg) merupakan salah satu mineral penting dalam tubuh yang memiliki fungsi memelihara kesehatan jantung, tulang, mengatur kadar gula darah hingga membantu mengatasi stres. Kebutuhan magnesium diantaranya dapat dipenuhi melalui Air Minum Dalam Kemasan (AMDK). Tujuan penelitian ini adalah untuk mengetahui perbedaaan kadar magnesium pada AMDK menggunakan metode spektrofotometri dan kompleksometri. Melalui perbandingan kedua metode tersebut dapat diketahui aplikasi metode yang lebih praktis dan efisien. Penentuan magnesium secara spektrofotometri dilakukan dengan mengukur terbentuknya senyawa kompleks Mg-EBT menggunakan spektrofotometer visibel pada panjang gelombang maksimum 530 nm. Hasil penelitian kadar magnesium pada AMDK metode spektrofotometri didapatkan kadar antara 1,5-19,45 mg/L, sedangkan dengan …