Digital Commons Network^™

Unsupervised Multi-Resolution Analysis Of Protein-Protein Abundance Patterns In Infectious Exacerbation Of Copd, Eric Everingham

Theses

Despite consistently appearing as a top 5 cause of death domestically and internationally, understandings of the underlying biological interactions of COPD remain insufficient. Particularly, early identification of highly vulnerable patients that may experience more severe infectious exacerbation is a challenge during diagnostics. This project leverages unsupervised clustering and multi-resolution decomposition of proteomic abundance profiles in a small cohort of COPD subjects to identify candidate biomarkers of heightened exacerbation risk. As part of an ongoing study, serum and sputum samples were collected during well visits (stable illness) from n=67 subjects, and analyzed using quantitative proteomics. A scores principal component analysis was …

Performance Evaluation Of Residential Design In Four Different Climate Zones Using Passive House Strategies And Metrics, Ian Luhmann

Theses

This study presents a comprehensive performance evaluation of residential designs across four different climate zones, employing Passive House strategies and metrics to achieve energy efficiency, comfort, and sustainability. The Passive House standard, recognized for its rigorous approach to energy-efficient buildings, is the cornerstone of this research. The objective is to adapt and optimize residential designs to meet the specific climate conditions of each zone while adhering to the Passive House principles and noting the modifications necessary to do so.

Enrichment-Planting With Pines Alters Fuel Amount And Structure In Endangered Araucaria Araucana Forests In Northwestern Patagonia, Argentina, Sofia Cingolani, Ignacio A. Mundo, Ivan Barbera, Andrés Holz, Thomas T. Veblen, Juan Paritsis

Geography Faculty Publications and Presentations

The introduction of non-native tree species for large-scale afforestation may alter the fire regime of native ecosystems by modifying fuel proprieties. We quantified changes in fuel abundance and structure resulting from the establishment of commercial Pinus spp. plantations in Araucaria araucana ecosystems in northwestern Patagonia, Argentina. Specifically, we assessed the amount, distribution, and condition (live/dead) of surface and standing fine fuel in A. araucana stands with mature pine plantations (i.e. > 20 cm dbh) and in stands dominated only by A. araucana (control). Our study shows that both types of stands are prone to wildfires, but pine plantations have fuel characteristics …

American Institution Of Public, K-12 Education: An Institutional Field Under A Complexity Paradigm, Jennifer Jean Joyalle

Dissertations and Theses

Institutional fields serve as foundational bedrocks that shape and govern behaviors, norms, and practices within distinct domains of societal and organizational interactions. The emergence of machine learning and the ability to manipulate large datasets offer researchers and decision makers the potential ability to model and visualize the behavior associated with institutional fields.

This proof of concept provides an example of visualizing the changing conditions in the institutional field of public K-12 education in America as a topology. By interweaving three primary strands of theory -- institutional fields, complexity in the guise of complex adaptive systems as a paradigm, and paradigms …

Early Diagnosis Methods For Autism Spectrum Disorder: A Systematic Review, Megan Denise Mccarthy

Doctoral Dissertations

Objective: This systematic review aimed to comprehensively synthesize existing literature on early detection methods for Autism Spectrum Disorder (ASD) in children birth to 3 years, that lead to an effective and reliable early diagnosis in children 2 to 3 years of age.

Methods: A systematic search was conducted across multiple electronic databases, including PubMed, Scopus, and PsycINFO following PRISMA guidelines. Studies reporting on early detection methods for ASD in infants and toddlers within ages 0 to 3 years that lead to early diagnosis of children ages 2 to 3 years were eligible for inclusion. Data extraction and quality assessment were …

Monitoring Time Domain Characteristics Of Parkinson's Disease Using 3d Memristive Neuromorphic System, Md Abu Bakr Siddique, Yan Zhang, Hongyu An

Michigan Tech Publications

INTRODUCTION: Parkinson's disease (PD) is a neurodegenerative disorder affecting millions of patients. Closed-Loop Deep Brain Stimulation (CL-DBS) is a therapy that can alleviate the symptoms of PD. The CL-DBS system consists of an electrode sending electrical stimulation signals to a specific region of the brain and a battery-powered stimulator implanted in the chest. The electrical stimuli in CL-DBS systems need to be adjusted in real-time in accordance with the state of PD symptoms. Therefore, fast and precise monitoring of PD symptoms is a critical function for CL-DBS systems. However, the current CL-DBS techniques suffer from high computational demands for real-time …

Sharing The Gospel With Ease: How The Love Of Christ Can Flow Naturally From Your Life, Jay C. Powell

Witness

No abstract provided.

Diversity And Dissemination Of Viruses In Pathogenic Protozoa, Senne Heeren, Ilse Maes, Mandy Sanders, Lon-Fye Lye, Vanessa Adaui, Jorge Arevalo, Alejandro Llanos-Cuentas, Lineth Garcia, Philippe Lemey, Stephen M Beverley, James A Cotton, Jean-Claude Dujardin, Frederik Van Den Broeck

2020-Current year OA Pubs

Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis and their dsRNA Leishmania virus 1. We show that parasite populations circulate in tropical rainforests and are associated with single viral lineages that appear in low prevalence. In contrast, groups of hybrid parasites …

Middle-Earth, Or There And Back Again, Edited By Łukasz Neubauer. Reviewed By Hamish Williams., Hamish Williams

Mythprint Book Reviews

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

Top Tips For Effective Use Of Periodontal Instruments In Primary Care, Morag Powell, Ruth Potterton, Ewen Mccoll

Peninsula Dental School

Stabilisation of primary disease is a key pillar of successful treatment and in addition to managing caries, managing periodontal disease is a crucial component of a successful treatment plan. The recent European Federation of Periodontology (EFP) S3 level clinical practice guidelines (CPG)1 are evidence‐based clinical guidelines providing recommendations to treat periodontitis. Crucial to successful implementation of these recommendations is delivering behavioural change and non-surgical instrumentation. Often this is given passing attention with insufficient time allocated to behaviour change in treatment planning. Similarly, poorly maintained periodontal instruments and equipment not used to their full utility or design can lead to poorer …

Combining The Tyrosine Kinase Inhibitor Cabozantinib And The Mtorc1/2 Inhibitor Sapanisertib Blocks Erk Pathway Activity And Suppresses Tumor Growth In Renal Cell Carcinoma, Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L Mudd, Jeremy Hoog, R Jay Mashl, Matthew A Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M Herndon, Sherri R Davies, Di Liu, Xi Ding, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C Fields, Kian-Huat Lim, Cynthia X Ma, Li Ding, Feng Chen, Et Al.

2020-Current year OA Pubs

UNLABELLED: Current treatment approaches for renal cell carcinoma (RCC) face challenges in achieving durable tumor responses due to tumor heterogeneity and drug resistance. Combination therapies that leverage tumor molecular profiles could offer an avenue for enhancing treatment efficacy and addressing the limitations of current therapies. To identify effective strategies for treating RCC, we selected ten drugs guided by tumor biology to test in six RCC patient-derived xenograft (PDX) models. The multitargeted tyrosine kinase inhibitor (TKI) cabozantinib and mTORC1/2 inhibitor sapanisertib emerged as the most effective drugs, particularly when combined. The combination demonstrated favorable tolerability and inhibited tumor growth or induced …

Validity And Reliability Of The Persian Version Of The Suboptimal Health Status Questionnaire Among University Staff In Iran, Erfan Ayubi, Salman Khazaei, Shiva Borzouei, Ali R. Soltanian, Samereh Ghelichkhani, Fatemeh Karbin, Yuxiang Yan, Manshu Song, Cuihong Tian, Wei Zhang, Jing Sun, Wei Wang

Research outputs 2022 to 2026

Background: Suboptimal Health Status Questionnaire-25 (SHSQ-25) is an established tool for measuring a precision health state between health and illness. The present study aims to assess the validity and reliability of a Persian version of SHSQ-25 (P-SHSQ-25) in a university staff Iranian population. Methods: A sample of 316 academic and supporting staff (163 males, age range from 23 to 64 years old) from Hamadan University of Medical Sciences, Hamadan, Iran was recruited in this population-based cross-sectional study with a questionnaire validation from Apri1 to October 2022. Forward-backward translation method was performed for the SHSQ-25 translation from English to Persian. Internal …

Field Notes: Leucistic Female Boat-Tailed Grackle, William E. Davis Jr.

Bird Observer

No abstract provided.

Thomas Nuttall: Pioneering Naturalist (1786-1859), John R. Nelson

Bird Observer

No abstract provided.

Nineteenth Report Of The Massachusetts Avian Records Committee, Matthew P. Garvey, Jeremiah R. Trimble, Marshall J. Iliff

Bird Observer

No abstract provided.

Gleanings: Getting From Point A To Point B, David M. Larson

Bird Observer

No abstract provided.

Musings From The Blind Birder: Birding Paraphernalia, Martha Steele

Bird Observer

No abstract provided.

Musings From The Blind Birder: Birding Vocabulary, Martha Steele

Bird Observer

No abstract provided.

Bird Sightings: November/December 2014, Seth Kellogg, Marjorie W. Rines, Robert H. Stymeist

Bird Observer

No abstract provided.

At A Glance: December 2014, Wayne R. Petersen

Bird Observer

No abstract provided.

Fourth Report Of The Maine Bird Records Committee, Trevor B. Persons, Louis R. Bevier, William J. Sheehan, Peter D. Vickery, Christopher A. Bartlett

Bird Observer

No abstract provided.

The Snowy Owl Winter Of 2013-14, Norman Smith

Bird Observer

No abstract provided.

About Books: Looking Back And Planning Ahead, Mark Lynch

Bird Observer

No abstract provided.

Birding At The Front: A Wartime Letter From Ludlow Griscom, David Swain

Bird Observer

No abstract provided.

About Books: Gang Of Four, Mark Lynch

Bird Observer

No abstract provided.

Birding Tyringham Valley, Ed Neumuth

Bird Observer

No abstract provided.

Ernst Mayr: Building On Charles Darwin’S Legacy In The Twentieth Century, William E. Davis Jr.

Bird Observer

No abstract provided.

Seventeenth Report Of The Massachusetts Avian Records Committee, Matthew P. Garvey, Marshall J. Iliff

Bird Observer

No abstract provided.

At A Glance: August 2013, Wayne R. Petersen

Bird Observer

No abstract provided.

The Birding John Nelsons, John Nelson

Bird Observer

No abstract provided.