Digital Commons Network^™

The Difference Method Makes: Judicial Restraint And Judicial Creativity In Rana Nahid V Sahidul Chisti, Saptarshi Mandal

National Law School Journal

Restraint and creativity are both necessary judicial attitudes. But when should judges exercise restraint in adjudication and when, creativity? This is the question posed by the Supreme Court’s 2020 split verdict in the case of Rana Nahid v Sahidul Chisti, which required the Court to decide whether Family Courts had jurisdiction over maintenance claims under the Muslim Women (Protection of Rights on Divorce) Act, 1986. By contrasting the two approaches taken by the judges to statutory interpretation in this case, the note argues that while judges should refrain from arbitrary rule making, creativity must be viewed as duty when …

Luis Sanchez, Petitioner/ Appellant V. State Of Utah, Respondent/ Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

APPELLANT’S RULE 10(c) PRINCIPAL MEMORANDUM IN SUPPORT OF REVERSAL

Ian L. Quiel, Debra M. Nelson, Benjamin Miller, Attorneys for Mr. Sanchez

Myod-Skp2 Axis Boosts Tumorigenesis In Fusion Negative Rhabdomyosarcoma By Preventing Differentiation Through P57kip2 Targeting, Silvia Pomella, Matteo Cassandri, Lucrezia D’Archivio, Antonella Porrazzo, Cristina Cossetti, Doris Phelps, Clara Perrone, Michele Pezzella, Antonella Cardinale, Marco Wachtel, Sara Aloisi, David Milewski, Marta Colletti, Prethish Sreenivas, Zoë S. Walters, Giovanni Barillari, Angela Di Giannatale, Giuseppe Maria Milano, Cristiano De Stefanis, Rita Alaggio, Sonia Rodriguez-Rodriguez, Nadia Carlesso, Christopher R. Vakoc, Enrico Velardi, Beat W. Schafer, Ernesto Guccione, Susanne A. Gatz, Lucio Miele

School of Medicine Faculty Publications

Rhabdomyosarcomas (RMS) are pediatric mesenchymal-derived malignancies encompassing PAX3/7-FOXO1 Fusion Positive (FP)-RMS, and Fusion Negative (FN)-RMS with frequent RAS pathway mutations. RMS express the master myogenic transcription factor MYOD that, whilst essential for survival, cannot support differentiation. Here we discover SKP2, an oncogenic E3-ubiquitin ligase, as a critical pro-tumorigenic driver in FN-RMS. We show that SKP2 is overexpressed in RMS through the binding of MYOD to an intronic enhancer. SKP2 in FN-RMS promotes cell cycle progression and prevents differentiation by directly targeting p27Kip1 and p57Kip2, respectively. SKP2 depletion unlocks a partly MYOD-dependent myogenic transcriptional program and strongly affects stemness and tumorigenic …

An Empirical Study Of Machine Learning Techniques For Accurate Stock Price Forecasting, Daniel Paliulis, Hari Patchigolla

Honors Scholar Theses

This paper presents a comprehensive approach to predicting future stock prices of companies using machine learning and time series analysis. The research problem is centered around addressing the complexity and emotion-driven nature of stock investment decisions. To create an objective determinant in stock decisions, we propose a machine learning model utilizing time series data from major companies, including Amazon, Apple, Google, Nvidia, Meta, Tesla, Salesforce, Intel, and Microsoft. We explore the use of Long Short-Term Memory (LSTM) neural networks, to capture the temporal dynamics of stock prices. These models are designed to process sequential data, maintaining short term and long …

Enniatin A Inhibits The Chaperone Hsp90 And Unleashes The Immune System Against Triple-Negative Breast Cancer, Nada H Eisa, Vincent M Crowley, Asif Elahi, Vamsi Krishna Kommalapati, Michael A Serwetnyk, Taoufik Llbiyi, Sumin Lu, Kashish Kainth, Yasmeen Jilani, Daniela Marasco, Abdeljabar El Andaloussi, Sukyeong Lee, Francis T F Tsai, Paulo C Rodriguez, David Munn, Esteban Celis, Hasan Korkaya, Abdessamad Debbab, Brian Blagg, Ahmed Chadli

Faculty, Staff and Students Publications

Low response rates and immune-related adverse events limit the remarkable impact of cancer immunotherapy. To improve clinical outcomes, preclinical studies have shown that combining immunotherapies with N-terminal Hsp90 inhibitors resulted in improved efficacy, even though induction of an extensive heat shock response (HSR) and less than optimal dosing of these inhibitors limited their clinical efficacy as monotherapies. We discovered that the natural product Enniatin A (EnnA) targets Hsp90 and destabilizes its client oncoproteins without inducing an HSR. EnnA triggers immunogenic cell death in triple-negative breast cancer (TNBC) syngeneic mouse models and exhibits superior antitumor activity compared to Hsp90 N-terminal inhibitors. …

Timigp: An R Package To Depict The Tumor Microenvironment From Bulk Transcriptomics, Chenyang Li, Jianjun Zhang, Chao Cheng

Faculty, Staff and Students Publications

Exploring the clinical relevance of diverse immune cell types within the tumor microenvironment is pivotal for unraveling cancer intricacies and developing treatments. Here, we present a protocol for using tumor immune microenvironment illustration based on gene pairs, an R package to deduce cell-cell interactions, unveiling the association between immune cell relative abundance and patient prognoses from bulk gene expression and survival data. We describe steps for harnessing cell-type markers derived from single-cell RNA sequencing data to map the tumor immune microenvironment across a spectrum of cancer types. For complete details on the use and execution of this protocol, please refer …

Lilrb3 Modulates Acute Myeloid Leukemia Progression And Acts As An Effective Target For Car T-Cell Therapy, Sunny Mai, Alan Hodges, Hui-Ming Chen, Jilu Zhang, Yi-Ling Wang, Yongbin Liu, Fumiko Nakatsu, Xiaoxuan Wang, Jing Fang, Yitian Xu, Vitaliy Davidov, Kyeongah Kang, Sai Ravi Pingali, Siddhartha Ganguly, Masataka Suzuki, Marina Konopleva, Brooke Prinzing, Youli Zu, Stephen Gottschalk, Yong Lu, Shu-Hsia Chen, Ping-Ying Pan

Faculty, Staff and Students Publications

Identifying novel cell surface receptors that regulate leukemia cell differentiation and can be targeted to inhibit cellular proliferation is crucial to improve current treatment modalities in acute myeloid leukemia (AML), especially for relapsed or chemotherapy-refractory leukemia. Leukocyte immunoglobulin-like receptor type B (LILRB) is an immunomodulatory receptor originally found to be expressed in myeloid cells. In this study, we found that LILRB receptors can be induced under inflammatory stimuli and chemotherapy treatment conditions. Blockade of LILRB3 inhibited leukemia cell proliferation and leukemia progression. Additionally, treatment with LILRB3 blocking antibodies upregulated myeloid lineage differentiation transcription factors, including PU.1, C/EBP family, and IRF, …

Terahertz Permittivity Parameters Of Monoclinic Single Crystal Lutetium Oxyorthosilicate, Sean Knight, Steffen Richter, Alexis Papamichail, Megan Stokey, Rafał Korlacki, Vallery Stanishev, Philipp Kühne, Mathias Schubert, Vanya Darakchieva

Department of Electrical and Computer Engineering: Faculty Publications

The anisotropic permittivity parameters of monoclinic single crystal lutetium oxyorthosilicate, Lu₂SiO₅ (LSO), have been determined in the terahertz spectral range. Using terahertz generalized spectroscopic ellipsometry (THz-GSE), we obtained the THz permittivities along the a, b, and c^⋆ crystal directions, which correspond to the ε_a; ε_b, and ε_c? on-diagonal tensor elements. The associated off diagonal tensor element ε_ac? was also determined experimentally, which is required to describe LSO’s optical response in the monoclinic a–c crystallographic plane. From the four tensor elements obtained in the model fit, we calculate the …

Convicting The Innocent: The Impact Of Wrongful Conviction In The U.S. Criminal Legal System, Aubrie Entwood

Theses

Wrongful conviction is a justice system error with far-reaching consequences. This capstone project looks at four different issues within wrongful conviction and exoneration in the U.S. criminal legal system. Chapter 1 focuses on the impacts of wrongful conviction for female exonerees, highlighting the way they are different from male exonerees, the factors that contribute to wrongful conviction that are more salient to females, and the specific ways the police and courts contribute to the wrongful conviction of females. Special attention is paid to the “crimes” of female exonerees and the additional psychological consequences that many female exonerees suffer. Ways in …

Aspirations Of Hispanic Criminal Justice Students To Join Law Enforcement: An Empirical Investigation, Yudu Li, Lucas Espinoza, Charlotte Hu, Fei Luo

Criminal Justice Faculty Publications

This study investigates the job preferences of criminal justice (CJ) students and potential factors that may impact their application for law enforcement positions. Existing research has shown that factors like gender, race, and class standing influence career choices among CJ majors. To contribute to this body of knowledge, this study focuses on CJ students’ attitudes toward the police and willingness to engage in community policing programs. The research examined 231 CJ students in a Hispanic serving university situated along the US-Mexican border. Research findings indicate that CJ students are less likely to pursue law enforcement careers if they hold less …

Disinfecting The Criminal Legal System Of Punitive Deterrence, Joseph Dole

DePaul Journal for Social Justice

No abstract provided.

The Religious Landscape Of Uruguay In The Third Millennium: Present Piety As A Product Of The Past?, Brandon Kriplean

Honors Theses

Of all Latin American countries, Uruguay enjoys both the lowest percentage of Catholics and the highest percentage of religiously unaffiliated. The central aim of this thesis is to explore the extent to which historical secularization processes and laicidad are responsible for the low number of Catholics and the large number of religiously unaffiliated. With regards to the former, the historical evidence suggests that the small Catholic population is not a result of laicidad but is instead a product of internal issues within the Uruguayan Catholic Church. Part 1 of this thesis will explore the factors that have weakened the Uruguayan …

Differences In Set-Based Tests For Sparse Alternatives When Testing Sets Of Outcomes Compared To Sets Of Explanatory Factors In Genetic Association Studies, Ryan Sun, Andy Shi, Xihong Lin

Faculty, Staff and Student Publications

Set-based association tests are widely popular in genetic association settings for their ability to aggregate weak signals and reduce multiple testing burdens. In particular, a class of set-based tests including the Higher Criticism, Berk-Jones, and other statistics have recently been popularized for reaching a so-called detection boundary when signals are rare and weak. Such tests have been applied in two subtly different settings: (a) associating a genetic variant set with a single phenotype and (b) associating a single genetic variant with a phenotype set. A significant issue in practice is the choice of test, especially when deciding between innovated and …

A Silent New Threat To The Trans Community: The Unregulated Use Of Ai Without Public Consent Raises Ethical Concerns, Eduardo Salazar Uribe

Capstones

Abstract:

The unregulated use of artificial intelligence (AI) without public consent has raised ethical concerns, particularly affecting marginalized communities such as transgender individuals. This project, based on interviews with 34 transgender people, explores the impact of AI on historically marginalized minorities, emphasizing the urgent need for an ethical and legal framework. This research reveals instances of discrimination and challenges faced by transgender individuals at various stages, from border control to airport security, highlighting the limitations and biases of AI in recognizing diverse gender identities. Trans rights activists, and AI experts remark the importance of inclusivity in AI development and regulation. …

Patient Education Improvement Initiative For Self-Management Of Congestive Heart Failure Among Senior Residents Of A Long-Term Care Facility, Abigail A. Abella, Brooke Sheck, Daniela Ramos, Ivy H. Nguyen, Mary Tran, Roshni Nagarajan

Master's Projects and Capstones

The purpose of this quality improvement project was to use evidence-based practices to determine if personalized education on disease self-management would lead to improved treatment adherence in a residential facility. The target population consisted of four elderly female patients who had been diagnosed with congestive heart failure (CHF) and were struggling with the self-management of their disease. Contributing barriers to effective CHF self-management were determined using a root cause analysis, and included a lack of educational templates, declining cognitive ability of the residents, and no electronic health record (EHR). Using the Self-Determination theory, the interventions were implemented. Phase one was …

Reducing Readmission Rates Within 30 Days Of Discharge By Increasing Frequency Of Calls By The East Bay Transitions Care Department, Rediet Abebe Gebremichael

Master's Projects and Capstones

Abstract

Background: Within the organization, the estimated cost of readmissions is $10,107.00 per day. Managing readmission rates within the hospitals has been challenging due to multiple factors. Readmissions cause financial and emotional stress on patients and their families, along with the stresses experienced during hospitalization.

Problem: The yearly readmission goal for the Transitions Care Department is below 14% per month. In 2022 the Transitions Care Department has been above 14% for most of the year, averaging 17%. Hospital readmissions impose a substantial financial and resource burden on the healthcare system.

Interventions: Staff training will ensure their effectiveness in carrying out …

Dodge The Fall: A Newborn Fall Prevention Initiative, Linda Nguyen

Master's Projects and Capstones

Problem: In the past year, three separate newborn fall incidents occurred on the postpartum unit at Hospital X. This project aims to increase nurse-to-patient education on newborn fall prevention, thereby reducing the number of newborn falls on the unit.

Context: This quality improvement project was implemented on the postpartum unit at a hospital located in San Francisco County. At this hospital, the postpartum unit consists of 10 beds in postpartum and 11 beds in antepartum. Currently, there is no standardized method used by registered nurses to prevent newborn falls.

Intervention: The requirement for mothers to sign the Pledge Form for …

Understanding The Cultural Perceptions And Beliefs Of Law Enforcement About Officer Wellness: A Focused Ethnography, Carrie Hintz

Electronic Theses and Dissertations

Law enforcement is recognized as one of the most stressful and high-risk occupations in the world. This study explored the cultural perceptions, beliefs, and values of law enforcement officers (LEOs) about their wellness. Methodology: This focused ethnography included observations and individual interviews of LEOs in the state of Nevada, USA. Leininger’s four phases of qualitative data analysis were used to analyze the data. Results: Thirty-one LEOs participated, representing 7 law enforcement agencies. Three themes were identified: 1) the badge is omnipresent in officers' lives, affecting every aspect of their world; 2) a balanced approach to officer health is important; …

Using Clinical Staff-Initiated Protocols In The Urgent Care Setting To Improve Throughput, Holly S. Mason

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

One of the goals and purposes of the urgent care setting is to provide quality patient care within a timely fashion. This process improvement project was designed to improve patient visit times in the urgent care setting, thus improving throughput. In this project, testing/imaging protocols were developed, agreed upon by the office healthcare providers, and utilized by clinical staff for patients who presented with complaints of 1) dysuria, 2) sore throat with an accompanying fever, 3) upper respiratory symptoms without an accompanying fever, 4) upper respiratory symptoms with an accompanying fever, and 5) an orthopedic injury known as a FOOSH …

Implementing Audiovisual Education To Improve Quality And Patient Experience For Outpatient Colorectal Cancer Screening Patients, Stephanie Armstrong

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Colorectal cancer continues to be the second most deadly cancer in the United States, with thousands of new cases being diagnosed each year. Comprehension of bowel preparation education is an important factor in ensuring patients follow purgative and diet instructions. Inadequate bowel preparations lead to longer procedure lengths, decreased cancer screening capabilities, and decrease patient satisfaction. Audiovisual education has been shown to positively impact patient comprehension and instruction adherence, when compared to the standard written education. The goal of this quality improvement project was to implement audiovisual education and identify whether it improved bowel preparation adequacy and patient satisfaction. The …

Lemons And Other Grand Delusions, Jake A. Yarnold

Master's Theses

Lemons and Other Grand Delusions explores a host of characters as they come face to face with their greatest fears, as they get exactly what they think they want. From magic dimension-bending lemons, to automatons powered by the Philosopher’s Stone, as the powers from beyond become in-hand realities, the characters find their greatest desires are not as simple and powerful in their hands as they first thought. Exploring the limits of greed and desire within ourselves and in the society we live in, the collection asks who are we, if not a collection of our own desires, and the impulses …

From Margins To Museums: Tracing The Evolution Of Representation For Contemporary African Artists In The United States, Victoria Mouraux Durand-Ruel

Master's Theses

This thesis examines the impact of the Black Lives Matter movement on the art community in the United States and the evolution of representation for Contemporary African artists. By analyzing the careers and artistic contributions of Omar Ba, Toyin Ojih Odutola, and Njideka Akunyili Crosby, the study explores the concept of artistic agency according to which African artists have more control over the production and distribution of their works.

The research begins with a comprehensive literature review, investigating the historical contexts that have shaped the art landscape, including the impact of colonization, decolonization, and globalization. The study reveals how these …

Effect Of Temperature And Steam-To-Carbon Monoxide (Co) Ratio On Hydrogen Production In Water-Gas Shift Reaction Using Cu-Zno-Al2o3 Catalyst, Sekar Kumala Desi, Restu Siti Nursa'adah, Hana Nabila Anindita, Bambang Muharto, Nurdiah Rahmawati, Tyas Puspita Rini, Erlan Rosyadi

Makara Journal of Science

This study investigates the effect of steam-to-CO molar ratio and temperature on hydrogen production in a water gas shift reaction using a Cu-ZnO-Al₂O₃ catalyst. Herein, different steam-to-CO molar ratios (1:1, 2:1, and 3:1) and temperatures (200 °C, 250 °C, and 300 °C) were applied to investigate their impact on the reaction and H₂ production. The Cu-ZnO-Al₂O₃ catalyst was characterized by its surface area, pore size distribution, and chemical composition. Moreover, the experimental setup enabled the control of temperature and steam-to-CO molar ratio while monitoring the product gas composition. The results revealed a considerable …

Combining The Tyrosine Kinase Inhibitor Cabozantinib And The Mtorc1/2 Inhibitor Sapanisertib Blocks Erk Pathway Activity And Suppresses Tumor Growth In Renal Cell Carcinoma, Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Yuefan Wang, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L Mudd, Jeremy Hoog, R Jay Mashl, Matthew A Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M Herndon, Sherri R Davies, Di Liu, Xi Ding, Yvonne A Evrard, Bryan E Welm, David Lum, Mei Yee Koh, Alana L Welm, Jeffrey H Chuang, Jeffrey A Moscow, Funda Meric-Bernstam, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C Fields, Kian-Huat Lim, Cynthia X Ma, Hui Zhang, Li Ding, Feng Chen

Faculty, Staff and Student Publications

Current treatment approaches for renal cell carcinoma (RCC) face challenges in achieving durable tumor responses due to tumor heterogeneity and drug resistance. Combination therapies that leverage tumor molecular profiles could offer an avenue for enhancing treatment efficacy and addressing the limitations of current therapies. To identify effective strategies for treating RCC, we selected ten drugs guided by tumor biology to test in six RCC patient-derived xenograft (PDX) models. The multitargeted tyrosine kinase inhibitor (TKI) cabozantinib and mTORC1/2 inhibitor sapanisertib emerged as the most effective drugs, particularly when combined. The combination demonstrated favorable tolerability and inhibited tumor growth or induced tumor …

Validity And Reliability Of The Persian Version Of The Suboptimal Health Status Questionnaire Among University Staff In Iran, Erfan Ayubi, Salman Khazaei, Shiva Borzouei, Ali R. Soltanian, Samereh Ghelichkhani, Fatemeh Karbin, Yuxiang Yan, Manshu Song, Cuihong Tian, Wei Zhang, Jing Sun, Wei Wang

Research outputs 2022 to 2026

Background: Suboptimal Health Status Questionnaire-25 (SHSQ-25) is an established tool for measuring a precision health state between health and illness. The present study aims to assess the validity and reliability of a Persian version of SHSQ-25 (P-SHSQ-25) in a university staff Iranian population. Methods: A sample of 316 academic and supporting staff (163 males, age range from 23 to 64 years old) from Hamadan University of Medical Sciences, Hamadan, Iran was recruited in this population-based cross-sectional study with a questionnaire validation from Apri1 to October 2022. Forward-backward translation method was performed for the SHSQ-25 translation from English to Persian. Internal …

T1 And Flair Signal Intensities Are Related To Tau Pathology In Dominantly Inherited Alzheimer Disease, Farzaneh Rahmani, Matthew R Brier, Brian A Gordon, Nicole Mckay, Shaney Flores, Sarah Keefe, Russ Hornbeck, Beau Ances, Nelly Joseph-Mathurin, Chengjie Xiong, Guoqiao Wang, Cyrus A Raji, Jorge J Libre-Guerra, Richard J Perrin, Eric Mcdade, Alisha Daniels, Celeste Karch, John C Morris, Randall J Bateman, Tammie L S Benzinger, Et Al.

2020-Current year OA Pubs

Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasive or logistically challenging) biomarker studies. We used 1104 longitudinal MR, 324 amyloid beta, and 87 tau positron emission tomography imaging sessions from 525 participants enrolled in the Dominantly Inherited Alzheimer Network Observational Study to extract novel imaging metrics representing the mean (μ) and standard deviation (σ) of standardized image intensities of T1-weighted and Fluid attenuated inversion recovery (FLAIR) MR scans. There was an exponential decrease in FLAIR-μ in mutation …

A Novel Application Of The Coras Framework For Ensuring Cyber Hygiene On Shipboard Radar, Gizem Kayisoglu, Pelin Bolat, Kimberly Tam

School of Engineering, Computing and Mathematics

No abstract provided.

Galonsky V. East 17th Llc

All Decisions

No abstract provided.

The Effect Of Bilingualism On Cognitive Development In Children Review Article, Amal Mahmoud Ali

Alustath Journal for Human and Social Sciences

Bilingualism has become an increasingly common phenomenon in today’s globalized world, with many children growing up exposed to two or more languages. As a result, there has been growing interest among researchers in understanding the impact of bilingualism on thinking development in young and children. Some studies confirmed that bilingualism can have a positive effect on children’s perception cognitive development, particularly in the zones of attention control, Operational memory, and cognitive flexibility. Dual-language learners may also have better Planning and organization skills, such as task-switching and inhibitory control, compared to monolingual children. These cognitive advantages may be due to the …

Examining Written Expression Curriculum-Based Measurement For Students With Emotional And Behavioral Challenges, John Elwood Romig, Hannah M. Mathews, Amanda A. Olsen

SAGE Open Access Agreement Publications-Archive

Students with emotional and behavioral challenges often struggle with writing. Curriculum-based measurement (CBM) is an assessment used for a variety of purposes including screening, progress monitoring, and data-based individualization. However, little research has examined technical properties of writing CBM data and supported inferences. This study examined criterion validity of two CBM tasks with the Test of Written Language-4 and whether writing fluency was affected by writing prompt type. Thirty-eight students in 7th–12th grades with emotional and behavioral challenges completed a descriptive writing task and a narrative writing task. Writing samples were scored for the number of words written, words spelled …