Digital Commons Network^™

The Implications Of The Halogen Atom On The Physical Stability Of Amorphous Solid Dispersions, Mustafa Bookwala

Electronic Theses and Dissertations

Amorphous solid dispersions (ASD), although a promising formulation strategy for poorly water-soluble drugs, are susceptible to rapid, spontaneous recrystallization owing to their metastable nature. Non-covalent interactions (NCI) between the drug and polymer are known to help prevent ASD physical destabilization. Conventionally, hydrogen-bonding (H-bonding) is considered important for ASD formation and persistence. However, carbon-bound halogen atoms, which are frequently present on drug molecules and can form specific halogen-bonds (X-bond) with the polymer, remain relatively unexplored with respect to their ability to stabilize ASDs. It was, therefore, hypothesized that the presence of a peripheral Br on bromopropamide, and Cl on chlorpropamide will …

Creative Therapies For Autism: Movement, Music, And Sandplay, Alena Slak

The Crown: Syracuse Honors Research Journal

No abstract provided.

Psychometric Functions On Word Recognition Test Exploring The Difference In Performance Between Mandarin-English Bilinguals And English Monolinguals On The Nu-6 Word Recognition Test, William Russell, Jamie Desjardins

The Crown: Syracuse Honors Research Journal

No abstract provided.

Unfair To Compare: Why Assumptions Shouldn’T Authorize Discourse, Gianna Rullo

The Crown: Syracuse Honors Research Journal

No abstract provided.

The Crown, Complete Issue - V1, The Crown

The Crown: Syracuse Honors Research Journal

No abstract provided.

Screening For Uterine Fibroids In Black Women, Winnie N. Kagendo

Doctor of Nursing Practice (DNP) Projects

Background: Uterine fibroids are benign growths in the uterine muscle that affect around 70% of women. Black women have a higher risk, with three times the likelihood of developing fibroids compared to other races.

Problem: The issue of uterine fibroids continues to be poorly addressed in healthcare settings. Black women continue to be particularly adversely impacted by this problem. There is a lack of better screening methods, leading to late detection and limited treatment options for those hoping to maintain fertility.

Methods: A quality improvement project was implemented at a primary care clinic in Loma Linda, California, using the Uterine …

Enhancing Mental Health Assessments For Hysterectomy Patients: Implementing A Depression Screening Tool For Healthcare Clinicians, Dede Mihedji

Doctor of Nursing Practice (DNP) Projects

Background: Hysterectomies are prevalent in the United States ranging from

5.1 to 5.8 per 1000 women (Harnod et al., 2018). A standardized screening tool for assessing preoperative depression could mitigate the worsening of postoperative depressive symptoms in patients scheduled for a hysterectomy. Local Problem: Currently, there is no standard practice for preoperative depression screening in hysterectomy patients. Studies have identified that a hysterectomy may increase the risk of cardiovascular events, menopause, depression, and other outcomes (Madueke-Laveaux et al., 2022). Methods: To address the gap, clinicians attended a fifteen-minute Zoom course on the Patient Health Questionnaire 9 (PHQ-9) and its …

Simulation-Based Adaptive Interface For Personalized Learning Of Ai Fundamentals In Secondary School, Sara Guerreiro-Santalla, Dalila Duraes, Helen Crompton, Paulo Novais, Francisco Bellas

STEMPS Faculty Publications

This paper presents the first results on the validation of a new Adaptive E-learning System, focused on providing personalized learning to secondary school students in the field of education about AI by means of an adaptive interface based on a 3D robotic simulator. The prototype tool presented here has been tested at schools in USA, Spain, and Portugal, obtaining very valuable insights regarding the high engagement level of students in programming tasks when dealing with the simulated interface. In addition, it has been shown the system reliability in terms of adjusting the students’ learning paths according to their skills and …

Measuring Perceived Medical School Stress (Pmss) Scores Among Physician Assistant Students, Ashley Sharp, Anna Worthley

Physician Assistant Capstones, 2020-current

Wellness curriculum was introduced at James Madison University’s PA program in 2019. The intervention is student-led by upperclassmen and is two-part, consisting of wellness seminars and peer group discussions with a heavy emphasis on wellbeing, stress reduction, coping strategies and burnout. The aim of seminars and student-led discussions have been to promote mental health awareness and mindfulness practices, so that students experience lower perceived stress and greater life satisfaction. Perceived stress has not been examined among physician assistant students using the Perceived Medical School Stress (PMSS) scale which measures students’ perception of stress over four areas: medical school curriculum and …

Focused Assessment With Sonography Exams Vs Ct Scan, Anne Kresge, Charlotte Mueller, Briar Tures

Physician Assistant Capstones, 2020-current

Blunt trauma is a common reason patients present to the emergency department. Providers must evaluate these patients quickly to get them the correct treatment, especially for intra-abdominal bleeding. Focused assessment with sonography for trauma (FAST) exams are growing in use to evaluate trauma patients for free fluid in the abdomen. To be valuable to emergency providers, it must be known how FAST exams compare to the gold standard evaluation, computed tomography (CT) scans. Searches were done on Pubmed and Scopus databases using terms “focused assessment with sonography for trauma” and “FAST exam CT blunt abdominal trauma.” Limits were added to …

Feasibility And Measurement Of Bedside Pumping In The Nicu: A Mixed Methods Study, Jessica Gomez

Dissertations and Theses (Open Access)

Abstract

Background: Supporting preterm infants with mother’s own milk (MOM) can improve health outcomes and decrease mortality.¹ Freshly pumped MOM, within four hours of expression, has the highest availability of bioactive components versus stored MOM. However, fresh milk is often not readily available due to the disconnected process of breastfeeding that occurs with preterm infants in the NICU. One convenient solution to improve access to fresh MOM is for the mother to pump at the infant's bedside. This intervention could improve the mother's pumping experience and provide the infant access to fresh MOM.

Purpose: This study aimed to evaluate …

Cardiac Vagal Dysfunction And Ventricular Arrhythmogenesis In Type 2 Diabetes Mellitus After Myocardial Infarction, Dongze Zhang

Theses & Dissertations

Diabetes is the eighth leading cause of death in the United States. Every eight seconds a person dies from diabetes around the world. Among various types of diabetes, type 2 diabetes mellitus (T2DM) is the most common form, representing 90% to 95% of all diabetes populations. The leading cause of mortality and morbidity in T2DM patients is cardiovascular disease, among which acute myocardial infarction (MI)-induced ventricular arrhythmia is the major cause of death in T2DM. Patients with T2DM are two to four times more likely to die from MI than non-diabetic patients. Although well-known therapies including better glycemic control have …

Targeting Metabolic Switches And Dna Damage Repair For The Treatment Of Human Diseases, Rasangi Chathurika Kankanam Pathirage

Theses & Dissertations

Tuberculosis and Cancer treatments share common challenges due to prolonged therapy, the necessity of combination therapy and severe side effects. Characterization of novel drug targets and identification of new drugs modulating such targets within the context of multidrug treatments will contribute to overcoming current therapeutic challenges.

Tuberculosis (TB) is one of the challenging diseases to treat due to the persistence of Mycobacterium tuberculosis (Mtb) in the dormant phase. Current TB drugs are more effective toward actively dividing bacteria and less effective toward dormant bacteria. The metabolic transition between actively dividing bacteria and dormant bacteria is driven by pivotal metabolic enzymes …

Feasibility Of A Laboratory Model For Evaluating The Use Of An Alternative Response Option In Mitigating Caregiver Treatment Integrity Errors, Jessie K. Weber

Theses & Dissertations

The current study assessed the feasibility of a laboratory model designed to evaluate options for mitigating common caregiver errors in the implementation of destructive behavior treatment. We developed a computer-based analogue to caregiver implementation of extinction for attention-maintained destructive behavior; the model included contingencies on both caregiver errors of commission and adherence to the treatment protocol. We also conducted a preliminary investigation of the effects of participant access to alternative activities as a potential strategy for mitigating integrity errors. Participants included 14 MTurk workers or staff in a severe behavior clinic, and individual response patterns revealed distinct sensitivities to the …

The Effect Of Non-Immersive Virtual Reality Radiographic Positioning Simulation On First-Year Radiography Students' Image Evaluation Of Routine Positioning Errors, Ellie M. Miller

Theses & Dissertations

Optimal radiographic image quality is critical because it affects the accuracy of the radiologist’s interpretation. Radiologic technologists are obligated to obtain diagnostic images while minimizing patient radiation. However, repeated images due to technologist error have increased in recent years. This study aimed to evaluate the effectiveness of non-immersive virtual reality (VR) simulation on first-year students’ image evaluation of common positioning errors on routine knee and lumbar spine protocols. Research questions were 1) Does guided instruction using non-immersive radiographic positioning simulation software lead to improved image evaluation scores? 2) How well do participants describe evaluation of positioning errors after guided instruction …

Biomechanics Of The Tip-Back Bend: An Analysis Of The Force System Via Translational Research, Lyndzie Brace

Theses & Dissertations

Purpose: The purpose of this study was to 1. experimentally (in vitro) quantify the force system acting on the molar and the incisor when a tip-back bend is placed on an auxiliary spring mounted on a base archwire and create a prediction model 2. to compare the type of tooth movement obtained from the prediction model (in-vitro) and the clinical outcome (in-vivo) data obtained from a previously conducted clinical trial. Methods: A computerized 3-dimensional (3D) orthodontic force tester (OFT) was used to quantify and compare the force systems generated from different combinations of tip-back bend archwires and base …

A Retrospective Survey Of Joint Mobilization Utilization During Clinical Internship Of Silliman University Physical Therapy Alumni, Lily Ann Bautista, Regina Bautista, Andrei Altavas, Leanna Bautista

Philippine Journal of Physical Therapy

Introduction: Physical therapy interns of Silliman University reported limited exposure to the application of joint mobilization techniques during their clinical internship training program. The study aimed to determine whether joint mobilization is utilized in physical therapy internships, including the barriers and challenges affecting its use. The study described (1) the interns' self-reported knowledge and awareness of the benefits, principles, type, and indications of joint mobilization, (2) the use of joint mobilization with regards to practice settings and locations, (3) the interns' self-assessment of competency to perform joint mobilization techniques after graduation, and (4) the barriers to increased utilization during clinical …

Acidosis-Mediated Increase In Ifn-Γ-Induced Pd-L1 Expression On Cancer Cells As An Immune Escape Mechanism In Solid Tumors, Philipp Knopf, Dimitri Stowbur, Sabrina H L Hoffmann, Natalie Hermann, Andreas Maurer, Valentina Bucher, Marilena Poxleitner, Bredi Tako, Dominik Sonanini, Balaji Krishnamachary, Sanhita Sinharay, Birgit Fehrenbacher, Irene Gonzalez-Menendez, Felix Reckmann, David Bomze, Lukas Flatz, Daniela Kramer, Martin Schaller, Stephan Forchhammer, Zaver M Bhujwalla, Leticia Quintanilla-Martinez, Klaus Schulze-Osthoff, Mark D Pagel, Marieke F Fransen, Martin Röcken, André F Martins, Bernd J Pichler, Kamran Ghoreschi, Manfred Kneilling

Faculty, Staff and Student Publications

Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L1) expression on cancer cells is mainly regulated by Interferon-gamma (IFN-γ), which induces T cell exhaustion and enables tumor immune evasion. In this study, we demonstrate that acidosis, a common characteristic of solid tumors, significantly increases IFN-γ-induced PD-L1 expression on aggressive cancer cells, thus promoting immune escape. Using preclinical models, we found that acidosis enhances the genomic expression and phosphorylation of signal transducer and activator of transcription …

Three-Dimensional Analysis Of Condylar Displacement After Orthognathic Surgery In Patients With Facial Asymmetry, Teresa Bae

Theses & Dissertations

Facial asymmetry is apparent when there is a clinically significant variation between the two halves of the face. There can be varying degrees of facial asymmetry and mild asymmetry can be treated by orthodontics alone. For severe facial asymmetry a combination of orthodontics and orthognathic surgery may be necessary. The condyle must be in a stable position following surgery to have functional and structural stability and prevent relapse. This research proposal is to perform a retrospective CBCT study on the displacement of the condyle following orthognathic surgery in patients with facial asymmetry. The CBCTs were obtained from Taipei Veterans General …

Moral Licensing: Causes And Consequences In Public Administration, Atefeh Sodeiri Javadi

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: Voluntary deviation from self-controlling which is known as moral licensing, individuals justify their immoral and counterproductive behavior depending on past creditable behaviors, without worrying about the loss of their reputation and esteem. The aim of the study is to identify the causes and consequences of moral licensing. Design/Methodology/Approach: The paradigm of the study is interpretive; its approach is qualitative and its strategy is grounded theory with emergent approach. In this regard, indepth, semi-structured interviews were conducted with managers and employees of public administration in northeastern Iran. Findings: The result of analysis of 17 interviews showed 119 codes, 63 concepts, …

Women Seldom Make History And Tradition: Patriarchal Originalism In Dobbs, Anna Greer

DePaul Journal for Social Justice

No abstract provided.

Impacts Of Perinatal Oxycodone Exposed Offspring In Early Adolescence, Adrian Flores

Theses & Dissertations

The Opioid Epidemic has been a point of public health interest for the last twenty years. In this time, use of prescription opioids has grown exponentially, including use by pregnant women. The initial crisis has been focused on mitigating immediate problems such as lowering the significant loss of life in overdoses and providing support to cessation. Despite these advancements a separate phenomenon is on the rise: The rise in neonatal opioid withdrawal syndrome in neonatal care and associated challenges for these children as they age.

Currently preclinical research and epidemiological data suggests that exposed children are at risk for experiencing …

Understanding The Effect Of Chikungunya Virus Infection On Bone Homeostasis, Enakshi Roy

Theses & Dissertations

Chikungunya virus (CHIKV) is a mosquito-borne virus that causes Chikungunya fever (CHIKF), characterized by high fever, headache, rash, and joint pain. With global travel on the rise, infections caused by CHIKV have emerged in new regions, expanding their geographic range and infecting susceptible hosts. Currently, no approved prophylactic or therapeutic measures exist to prevent or treat these infections, with prevention strategies primarily focused on vector control. However, these measures have proven inadequate due to the emergence of mutations that enhance viral transmission or vector range. Therefore, urgent attention is needed to develop therapies to treat the infection. Although CHIKV has …

A Community-Based Participatory Research Approach To Addressing Pediatric Asthma Disparities In Douglas County, Nebraska, Aislinn Rookwood

Theses & Dissertations

Pediatric asthma is the leading chronic disease among children in the United States, and the incidence of pediatric asthma is increasing every year. Nebraska has an asthma prevalence comparable to the United States average; however, the state has significant disparities by county, race, and geographic location, with prevalence rates much higher than the national average. Douglas County is a hot spot for increased pediatric asthma rates, with further differences in rates by race and geographic location within the county. The University of Nebraska Medical Center, in partnership with Healthy Housing Omaha and the Nebraska Asthma Coalition, collaborated to conduct this …

Inclusive Education For All: Identifying Teacher Beliefs About Working With Students With Disabilities, Chelsea Sharek

Electronic Theses and Dissertations

The purpose of this study was to investigate the beliefs K-12 teachers have when working with students with disabilities in a rural Pennsylvania school district. This study aimed to identify if teachers’ personal beliefs created biases about their students and school systems; thus, forming barriers and preventing an inclusive education when working with disabled students. Instrumentation for this quantitative study is the Multidimensional Attitudes Towards Inclusive Education Scale (MATIES) survey. Findings suggest that some teachers at Sunnyside School District (pseudonym) hold personal beliefs that could create biases about their students and school system that may form barriers when working with …

Interactive Effects Of Sublethal Concentrations Of Fracking Biocides And Abandoned Mine Drainage On Amphipod Behavior, Kelly Lenhart

Electronic Theses and Dissertations

This thesis examined the sublethal effects of three pollutants, namely glutaraldehyde, 4,4-dimethyloxazolidine (DMO), and abandoned mine drainage (AMD), on amphipods. The primary objective was to investigate their combined effects on amphipods. The three pollutants, despite having the potential to combine in the environment, have not been studied to determine their potential for detrimental interactive effects which could result in unexpected environmental damage.

The research employed a series of experimental setups involving controlled exposure of amphipods to varying, putatively sublethal, concentrations of the chemicals of interest. Subsequently, effects were assessed via both behavioral and feeding assessments. To facilitate this analysis, novel …

Functionalized Surface Of Plga Nanoparticles In Thermosensitive Gel To Enhance The Efficacy Of Antibiotics Against Antibiotic Resistant Infections In Endodontics: A Randomized Clinical Trial, Mona Arafa, Hadeel Moussa, Mohamed Medhat Kataia

Pharmacy

Enterococcus faecalis plays the key role in endodontic infections and is responsible for the formation of biofilm on dentin, which causes a resistance against periradicular lesions treatment, consequently the aim of this study is to use nanoparticles entrapping anibacterial agents coated with chitosan that in authors previous study showed a successful in vitro biofilm inhibition, additionally incorporated in thermoresponsive gel.to benefit nanoparticles` small size, and the positive charge of their surfaces that binds with the negatively charged surface of bacterial cell causing its destruction, in addition to the sustained release pattern of the drug based nanoparticles in gel. Therefore, Ciprofloxacin …

Optimizing Sepsis Management Through Enhanced Protocol Compliance In The Emergency Department, Oscar J. Castillo

Master's Projects and Capstones

Problem: The Quality Improvement (QI) Project focused on improving early sepsis management and sepsis bundle adherence among Emergency Department (ED) nurses to decrease sepsis mortality rates and avoidable length of hospital stays (LOS).

Context: A group of Clinical Nurse Leaders (CNL) students evaluated sepsis protocol compliance at Hospital A's ED, which provides critical care for patients with various medical conditions. The CNL students concentrated on patients identified with sepsis for the QI Project.

Interventions: Limitations and time did not allow for the implementation of interventions. Recommendations offered to management included increasing sepsis training biannually and intravenous placement skills, offering sepsis …

Jews And Urban Life, Leonard J. Greenspoon

Studies in Jewish Civilization

Jews and Urban Life recognizes that throughout their long history, Jews have often inhabited cities. The reality of this urban experience ranged from ghetto restrictions to robust participation in a range of civic and social activities. Essays in this collection present relevant examples from within the Jewish community itself, moving historically from the biblical period to the modern-day State of Israel. Taking a comparative approach while recognizing the particulars of individual instances, authors examine these phenomena from a wide variety of approaches, genres, and media. Interdisciplinary and accessibly written, the articles display a multitude of instances throughout history showing the …

Avoiding Burnout: Newsletters That Promote Special Education Teachers Well-Being, Kayler Knott

Dissertations, Theses, and Projects

With the alarming rate of teachers leaving the educational field, there is a definitive shortage of people entering the field of special education. Educators need access to different tools and resources that will allow them to know about other things that can help limit or reduce the strain of things causing teacher burnout. By sending out these resources to educators and informing them of different tools they can use, we can help alleviate teacher burnout, keep more educators in the fields, and stop losing our young teachers just entering before they have even completed student teaching experiences. Each of these …