Digital Commons Network^™

Unttangling Irregular Actin Cytoskeleton Architectures In Tomograms Of The Cell With Struwwel Tracer, Salim Sazzed, Peter Scheible, Jing He, Willy Wriggers

Computer Science Faculty Publications

In this work, we established, validated, and optimized a novel computational framework for tracing arbitrarily oriented actin filaments in cryo-electron tomography maps. Our approach was designed for highly complex intracellular architectures in which a long-range cytoskeleton network extends throughout the cell bodies and protrusions. The irregular organization of the actin network, as well as cryo-electron-tomography-specific noise, missing wedge artifacts, and map dimensions call for a specialized implementation that is both robust and efficient. Our proposed solution, Struwwel Tracer, accumulates densities along paths of a specific length in various directions, starting from locally determined seed points. The highest-density paths originating …

A Structure-Aware Generative Adversarial Network For Bilingual Lexicon Induction, Bocheng Han, Qian Tao, Lusi Li, Zhihao Xiong

Computer Science Faculty Publications

Bilingual lexicon induction (BLI) is the task of inducing word translations with a learned mapping function that aligns monolingual word embedding spaces in two different languages. However, most previous methods treat word embeddings as isolated entities and fail to jointly consider both the intra-space and inter-space topological relations between words. This limitation makes it challenging to align words from embedding spaces with distinct topological structures, especially when the assumption of isomorphism may not hold. To this end, we propose a novel approach called the Structure-Aware Generative Adversarial Network (SA-GAN) model to explicitly capture multiple topological structure information to achieve accurate …

Ecolabeling In The Multinational Mining Industry: A Method Toward Environmental Sustainability, Regina Raze

Vanderbilt Journal of Transnational Law

The international mining industry's environmental impact is not new. However, with the rise of international scrutiny on climate change and global warming, what the industry can do to lessen its impact is changing. Consumers are demanding stronger commitments to the environment from producers, and producers are therefore requiring stronger commitments from their suppliers. One such commitment the extractive industry can adhere to is implementing an ecolabeling regime for open pit mines mining critical minerals for consumer products. Ecolabels signal to customers that the environment is a priority for companies. However, with an ecolabel comes trade implications and concerns about accuracy. …

Notes On Continental Constitutional Identities, Benjamen F. Gussen

Vanderbilt Journal of Transnational Law

Geo-constitutional analysis examines the reciprocal effect of geography on constitutions. Within this analysis, a continental constitutional identity focuses on the intersection between institutional geographies and institutional identities, where constitutions are understood as meta-institutions. In some constitutions, belonging to a continent is part of the national identity, while other constitutions only signal a non-geographic, usually an ethnic, identity. The US Constitution is an example of the former. The quintessential example of a non-geographic constitution is the Constitution of the Russian Federation. A similar disregard of continental identities can be found in Israel and the Arab League countries east of the Sinai …

Promoting Female Sporting Opportunities Without Title Ix: The Spanish Experience, Stephen Ross, Maria Josefa Garcia Cirac

Faculty Scholarship

This article compares the American approach to improving sporting opportunities for females – Title IX – with approaches taken by Spain. Because of the singular American dedication to elite interscholastic and intercollegiate sports, Title IX’s requirement of equal treatment requires that elite female athletes have equivalent opportunities to elite male athletes. The Spanish approach looks instead on the social benefits of athletics participation for boys, men, girls, and women.

Methods Of Teaching Early Literacy, Nandita Gurjar, Sohyun Meacham, Constance Beecher

Faculty Book Gallery

Theories, teaching strategies, and instructional materials pertinent to teaching reading and writing in grades PK-3, with an emphasis on integrating reading, writing, speaking, and listening, as well as integration across content areas while addressing diversity and inclusion. -- Provided by the publisher

Communication For College, Career, And Civic Life, Ryan Mcgeough, C. Kyle Rudick, Danielle Dick Mcgeough, Kathryn B. Golsan

Faculty Book Gallery

To address the challenges facing us as a society and a species, students must develop a robust set of skills, ethics, and dispositions that help them work with others to promote justice, peace, and equity. This OER, in promoting a robust set of communication skills, will serve as a foundational preparation for students who want to be successful in their education, careers, and civic lives.

Prison Litigation: Doctrine And Animus In California’S Covid-19 Prison Litigation, Hadar Aviram

The Judges' Book

No abstract provided.

Civil Litigation: Optimism And Expenditures: The Effect On Settlements, Ben Depoorter

The Judges' Book

No abstract provided.

Efficient Gpu Implementation Of Automatic Differentiation For Computational Fluid Dynamics, Mohammad Zubair, Desh Ranjan, Aaron Walden, Gabriel Nastac, Eric Nielsen, Boris Diskin, Marc Paterno, Samuel Jung, Joshua Hoke Davis

Computer Science Faculty Publications

Many scientific and engineering applications require repeated calculations of derivatives of output functions with respect to input parameters. Automatic Differentiation (AD) is a method that automates derivative calculations and can significantly speed up code development. In Computational Fluid Dynamics (CFD), derivatives of flux functions with respect to state variables (Jacobian) are needed for efficient solutions of the nonlinear governing equations. AD of flux functions on graphics processing units (GPUs) is challenging as flux computations involve many intermediate variables that create high register pressure and require significant memory traffic because of the need to store the derivatives. This paper presents a …

Claimdistiller: Scientific Claim Extraction With Supervised Contrastive Learning, Xin Wei, Md Reshad Ul Hoque, Jian Wu, Jiang Li

Computer Science Faculty Publications

The growth of scientific papers in the past decades calls for effective claim extraction tools to automatically and accurately locate key claims from unstructured text. Such claims will benefit content-wise aggregated exploration of scientific knowledge beyond the metadata level. One challenge of building such a model is how to effectively use limited labeled training data. In this paper, we compared transfer learning and contrastive learning frameworks in terms of performance, time and training data size. We found contrastive learning has better performance at a lower cost of data across all models. Our contrastive-learning-based model ClaimDistiller has the highest performance, boosting …

A Single-Cell Atlas Of Bovine Skeletal Muscle Reveals Mechanisms Regulating Intramuscular Adipogenesis And Fibrogenesis, Leshan Wang, Peidong Gao, Chaoyag Li, Qianglin Liu, Zeyang Yao, Yuxia Li, Xujia Zhang, Jiangwen Sun, Constantine Simintiras, Matthew Welborn, Kenneth Mcmillin, Stephanie Oprescu, Shihuan Kuang, Xing Fu

Computer Science Faculty Publications

Background: Intramuscular fat (IMF) and intramuscular connective tissue (IMC) are often seen in human myopathies and are central to beef quality. The mechanisms regulating their accumulation remain poorly understood. Here, we explored the possibility of using beef cattle as a novel model for mechanistic studies of intramuscular adipogenesis and fibrogenesis.

Methods: Skeletal muscle single-cell RNAseq was performed on three cattle breeds, including Wagyu (high IMF), Brahman (abundant IMC but scarce IMF), and Wagyu/Brahman cross. Sophisticated bioinformatics analyses, including clustering analysis, gene set enrichment analyses, gene regulatory network construction, RNA velocity, pseudotime analysis, and cell-cell communication analysis, were performed to elucidate …

Laws Governing Restrictions On Charitable Gifts: The Consequences Of Codification, Nancy Mclaughlin

Utah Law Faculty Scholarship

Over the last two decades we have seen marked changes in the laws governing donor-imposed restrictions on charitable gifts. These changes have occurred primarily as a result of the adoption in many states of the Uniform Trust Code (the UTC) and the Uniform Prudent Management of Institutional Funds Act (UPMIFA). This Essay explains that codification in the UTC and UPMIFA of liberalized versions of cy pres and deviation, as well as other related changes to the common law, have had unintended negative consequences. Those negative consequences include a lack of coherence in the law, an elevation of form over substance …

Holding Enablers Of Child Sexual Abuse Accountable: The Case Of Jeremy Bell, Amos N. Guiora, Valeri Craigle, Aya Hibben, Henry F. Fradella

Utah Law Faculty Scholarship

In the United States, 1 in every 5 women and 1 in every 13 men report being sexually abused as a child. Of the child sexual abuse that occurs during the K-12 years, much of it is aided and abetted by those in positions of authority who look the other way when abuse is known or suspected. This article uses the novel approach of holding not just the perpetrators of child sexual abuse accountable for these crimes, but also those who enable their criminal acts by failing to report suspicious behaviors or witnessed accounts of abuse. No case in more …

Police Secrecy Exceptionalism, Christina Koningisor

Utah Law Faculty Scholarship

Every state has a set of transparency statutes that bind state and local governments. In theory, these statutes apply with equal force to every agency. Yet, in practice, law enforcement agencies enjoy a wide variety of unique secrecy protections denied to other government entities. Legislators write police-specific exemptions into public records laws. Judges develop procedural approaches that they apply exclusively to police and prosecutorial records. Police departments claim special secrecy protections from the bottom up.

This Article maps the legal infrastructure of police-records secrecy. It draws upon the text of the public records statutes in all fifty states, along with …

Why Stop Grazing The Climate Commons?, Brigham Daniels

Utah Law Faculty Scholarship

Many have argued that climate change is the textbook example of a tragedy of the commons. Assuming that is correct, to make headway on climate change, we would expect an enforceable agreement that provides for global collective action. The tragedy of the commons assumes that those who cut back when others do not are—to use the formal language of game theorists—suckers. So, the last thing we would expect is a surge of unilateral action. Contrary to theory, for the past decade, unilateral climate action has flourished among governments, businesses, other organizations, and individuals.

Is the number of climate suckers growing …

Religious Gerrymandering: A New Avenue For Redistricting Challenges?, Jacqueline Rosen

Utah Law Faculty Scholarship

Recently, the Supreme Court significantly limited review of partisan gerrymandering claims, closing the door to a substantial portion of redistricting challenges. However, religious-based redistricting is an overlooked area that should be explored under both federal and state Constitutions. Existing redistricting standards can easily be applied to religious gerrymandering claims. In addition, the federal Establishment Clause may provide a basis for some especially egregious instances of religious gerrymandering. However, perhaps the least explored and most viable avenue for relief is through reliance on state constitutional protections, such as the unique language of Utah’s Constitution. Using Utah as a case study, I …

Campus-Wide Student Learning Assessment At The University Of Minnesota Morris For Academic Year 2022-2023, University Of Minnesota - Morris

Institutional Effectiveness and Research Reports

No abstract provided.

Artificial Intelligence-Driven Meta-Analysis Of Brain Gene Expression Identifies Novel Gene Candidates And A Role For Mitochondria In Alzheimer’S Disease, Caitlin A Finney, Fabien Delerue, Wendy A Gold, David A Brown, Artur Shvetcov

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is the most common form of dementia. There is no treatment and AD models have focused on a small subset of genes identified in familial AD. Microarray studies have identified thousands of dysregulated genes in the brains of patients with AD yet identifying the best gene candidates to both model and treat AD remains a challenge. We performed a meta-analysis of microarray data from the frontal cortex (n = 697) and cerebellum (n = 230) of AD patients and healthy controls. A two-stage artificial intelligence approach, with both unsupervised and supervised machine learning, combined with a functional …

The Assembled Genome Of The Stroke-Prone Spontaneously Hypertensive Rat, Theodore S Kalbfleisch, Nahla A Hussien Abouel Ela, Kai Li, Wesley A Brashear, Kelli J Kochan, Andrew E Hillhouse, Yaming Zhu, Isha S Dhande, Eric J Kline, Elizabeth A Hudson, Terence D Murphy, Françoise Thibaud-Nissen, Melissa L Smith, Peter A Doris

Faculty, Staff and Student Publications

BACKGROUND: We report the creation and evaluation of a de novo assembly of the genome of the spontaneously hypertensive rat, the most widely used model of human cardiovascular disease.

METHODS: The genome is assembled from long read sequencing (PacBio HiFi and continuous long read data [CLR]) and scaffolded with long-range structural information obtained from Bionano optical maps and proximity ligation sequencing proximity analysis of the genome. The genome assembly was polished with Illumina short reads. Completeness of the assembly was investigated using Benchmarking Universal Single Copy Orthologs analysis. The genome assembly was also evaluated with the rat reference gene set, …

Pain Experience And Sensory Changes In Astronauts During And After Short-Lasting Commercial Spaceflight: A Proof-Of-Concept Study, Andrea K Sauer, Marie Vigouroux, Patrick M Dougherty, Juan Pablo Cata, Pablo M Ingelmo

Faculty, Staff and Student Publications

Space travel has been associated with musculoskeletal pain, yet little is known about the nociceptive changes and pain experience during spaceflight. This preliminary study aims to investigate the pain experience and sensory alterations in astronauts following a 17-day mission to the International Space Station (ISS) on Axiom Space's AX-1 commercial space flight. Two participants were enrolled, and data were collected pre-flight, in-flight, post-flight, and three-month post-flight. Validated pain questionnaires assessed anxiety, catastrophizing, impact on physical and mental health, disability, and overall pain experience. Qualitative interviews were conducted post-landing and conditioned pain modulation (CPM) and quantitative sensory testing (QST) were performed. …

A Comparative Analysis Of Radical Cystectomy With Perioperative Chemotherapy, Chemoradiation Therapy, Or Systemic Therapy In Patients With Clinically Advanced Node-Positive Bladder Cancer (Cn2/N3), Harshit Garg, Mukund Bhandari, Furkan Dursun, Michael A Liss, Dharam Kaushik, Robert S Svatek, Ahmed M Mansour

Faculty, Staff and Student Publications

Introduction: The management of non-metastatic clinically advanced lymph nodal (cN2/N3) bladder cancer (Stage IIIB) could involve radical cystectomy, chemoradiation, or systemic therapy alone. However, a definitive comparison between these approaches is lacking. This study aims to compare the outcomes of patients undergoing radical cystectomy with pelvic lymph node dissection (RC-PLND), chemoradiation therapy (CRT) or systemic therapy (including immunotherapy) (ST) only in patients with stage IIIB bladder cancer.

Materials and methods: A retrospective analysis of the National Cancer Database for patients with stage IIIB urothelial bladder cancer was done from 2004-2019. Patients were classified as Group A: Those who received RC-PLND …

Former Juvenile Delinquents’ Perceptions Of Community Resources In Reducing Juvenile Recidivism, Mardochee Terese Casimir

Walden Dissertations and Doctoral Studies

AbstractJuvenile recidivism is a concern for human service professionals who are dedicated to developing policies aimed at addressing and reducing such recidivism. The purpose of this generic qualitative study was to explore the perceptions of former juvenile delinquents as to how community institutions and resources prevented them from recidivating. Social learning theory was used to frame this study. Data were collected through semistructured interviews with nine former juvenile delinquents who had experience with community institutions and resource use. Saldana’s inductive coding process was used for data analysis. Nine themes were identified: (a) behavior modification contributed to prevention of recidivism, (b) …

Strategies For Improving Performance Through Diversity And Inclusion In The Workplace, Satari Kay Durrah

Walden Dissertations and Doctoral Studies

A lack of diversity and inclusion policies can lead to the perception of exclusion in the workplace and cause some employee groups to underperform. Some hospital leaders lack strategies for developing and implementing effective diversity and inclusion policies to improve business performance. Grounded in transformation leadership theory, the purpose of this multiple case qualitative study was to explore strategies for improving performance through diversity and inclusion in the healthcare field. The participants included four leaders from hospitals located in the southeastern region of the United States. Data were collected using semistructured interviews and review of company documents. Data were analyzed …

Local Anesthetic Systemic Toxicity Education For Perianesthesia Nurses, Rachelle Lynn Dix

Walden Dissertations and Doctoral Studies

Local anesthetic systemic toxicity (LAST) is a potentially life-threatening event following a local anesthetic bolus into the circulatory system. Because LAST is a low-volume, high-risk event, clinical exposure is lacking, creating a knowledge gap among perianesthesia nurses. A knowledge gap regarding LAST among perianesthesia nurses was identified at the project site, an ambulatory surgery center in south Mississippi. The practice-focused question was: Whether a web-based education intervention would increase perianesthesia nurses’ knowledge about LAST. The doctoral project aimed to provide perianesthesia nurses with the clinical knowledge essential for early detection of LAST symptoms. A LAST education module was developed using …

Co-Rumination In The Friendships Of Black And White Adolescents, Andrea Renee Gourdine

Walden Dissertations and Doctoral Studies

Co-rumination is the process of friends discussing challenges via a problem-focused dialogue that is excessive and involves dwelling on negative emotions. Co-rumination is related to higher friendship quality but also depression. The adjustment consequences of co-rumination have been studied, but racial differences in co-rumination have yet to be studied. The purpose of this non-experimental, correlational, quantitative study was to examine co-rumination among Black and White adolescents. Theoretical frameworks included the response styles theory and Africentric theory. Research questions included whether there were racial differences in the degree to which adolescents co-ruminate and in the relations of co-rumination with friendship quality …

How It Professionals Acquire Soft Skills, Paul Majett

Walden Dissertations and Doctoral Studies

AbstractIn this study, I investigated how information technology (IT) professionals learn/acquire soft skills. Little is understood about how IT professionals describe and apply the soft skills that they consider necessary for their own employability. Exploring how IT professionals describe and apply soft skills is important to their future work and career advancement. The purpose of this basic qualitative study was to better understand how IT professionals learn/acquire soft skills. Bandura’s 1986, social learning theory served as the organizational conceptual framework of this study and guided the research question, which asked how IT professionals acquire learn/acquire soft skills. This research question …

Dietary Changes In Preventing Type Ii Diabetes Mellitus Among Young Hispanic Adults, Taiwo Onipede

Walden Dissertations and Doctoral Studies

Diabetes mellitus continues to be a major chronic disease affecting the global population today with more prevalence amongst minority groups in the United States. The genetic susceptibility to obesity and higher insulin resistance seen in the Hispanic population puts them at the highest risk for development of Type II Diabetes (T2DM). The alarming increase in young adult T2DM diagnosis led to the project question: How can teaching on dietary changes affect Type II Diabetes diagnosis in predisposed young Hispanic adults? The purpose of this project is to accomplish the goal of Healthy People 2020 towards improving the quality of life …

Clinical Vaccination Education Guideline For The African American Community, Margaret Chinedum Nwoji

Walden Dissertations and Doctoral Studies

AbstractVaccination hesitancy is high among African Americans and other people of color. The practice gap addressed in this project was the lack of a culturally sensitive clinical guideline for vaccination education relevant to the African American community. The practice-focused question was answered by developing an evidence-based Clinical Vaccination Education Guideline for the African American Community (CVEGAAC) that was validated by a group of four content experts using the Appraisal of Guidelines, Research, and Evaluation tool. The content experts scored each of the domains above 90%, implying that the CVEGAAC is of high quality and ready for implementation. The end users …

The Disaster Health System: Built For Collaboration And Coordination In A Complex Environment, Leslie E. Taylor

Walden Dissertations and Doctoral Studies

This qualitative case study examined patient distribution and coordination during complex, rapidly changing, uncertain emergencies or disasters. The study explored how Washington State’s Northwest Healthcare Response Network (NHRN) uses the state’s patient tracking system, WaTrac, as a collaboration tool for Emergency Support Function 8 (ESF 8) and public health emergency operations. This study used complexity theory to address a gap in the literature, acknowledging the importance of relationships among members of the NHRN and how the patient tracking system could enhance positive patient outcomes. This study included nine healthcare response participants; all were members of the NHRN healthcare coalition serving …