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Accessibility Of Health Data Representations For Older Adults: Challenges And Opportunities For Design, Peterson Jean, Emma Murphy, Enda Bates

Books/Book Chapters

Health data of consumer off-the-shelf wearable devices is often conveyed to users through visual data representations and analyses. However, this is not always accessible to people with disabilities or older people due to low vision, cognitive impairments or literacy issues. Due to trade-offs between aesthetics predominance or information overload, real-time user feedback may not be conveyed easily from sensor devices through visual cues like graphs and texts. These difficulties may hinder critical data understanding. Additional auditory and tactile feedback can also provide immediate and accessible cues from these wearable devices, but it is necessary to understand existing data representation limitations …

"I Just Want To Be Me, Authentically": Identity Shifting Among Racially And Ethnically Diverse Young Adults, Aerika Brittian Loyd, Dulce Wilkinson Westberg, Lenisha Williams, Marisha Humphries, Alan Meca, Julie Carmen Rodil

Psychology Faculty Publications

Identity shifting represents a common but complex social, behavioral, and cognitive phenomenon. However, some forms of identity shifting originate in response to structural, institutional, and interpersonal marginalization enacted on lower status groups, such as people of color in the United States. The current study investigated ways young adults from diverse ethnic/racial groups discussed shifting to fit in with White Americans (a dominant group) in the United States and their own ethnic/racial group (a minoritized group) and elucidated self-reported motivations for shifting. Participants consisted of 764 young adults (ages = 18–23) recruited from two large public universities in the Southeast and …

Criterion Validity Of Protective Behavioral Strategies For Alcohol Consumption Among College Students, Abby L. Braitman, Amy Stamates, Melissa Colangelo, Sarah J. Ehlke, Jordan Ortman, Kristin E. Heron, Kate B. Carey

Psychology Faculty Publications

Background: Protective behavioral strategies (PBS), or behaviors used to reduce harm associated with alcohol use, are often associated with lower levels of alcohol consumption, lower engagement in high-risk drinking behaviors, and fewer alcohol-related consequences. Although the majority of studies have found significant associations between higher PBS use and lower consumption or consequences, some studies have found nonsignificant or even positive associations. One explanatory hypothesis is that the mixed findings are due to differential content in PBS measures. Objectives: The current study examined the criterion validity of two widely-used PBS measures, the PBSS and the SQ. In a multi-institution online …

Target Recognition By Rnase E Rna-Binding Domain Ar2 Drives Srna Decay In The Absence Of Pnpase, Pranathi Gullapalli, Nicoletta Fossati, Dusica Stamenkovic, Muhammad Haque, Davide Cattano

Faculty, Staff and Student Publications

The human brain contributes 2% of the body weight yet receives 15% of cardiac output and demands a constant supply of oxygen (O 2) and nutrients to meet its metabolic needs. Cerebral autoregulation is responsible for maintaining a constant cerebral blood flow that provides the supply of oxygen and maintains the energy storage capacity. We selected oxygen administration-related studies published between 1975-2021 that included meta-analysis, original research, commentaries, editorial, and review articles. In the present narrative review, several important aspects of the oxygen effects on brain tissues and cerebral autoregulation are discussed, as well the role of exogenous O 2 …

Live Imaging Of Microglia During Sleeping Sickness Reveals Early And Heterogeneous Inflammatory Responses, Nestor L Uzcategui, Sena Güçer, Cris Richter, Annika Speidel, Elizabeta Zirdum, Michael Duszenko, Olga Garaschuk, Katherine Figarella

Faculty, Staff and Student Publications

INTRODUCTION: Invasion of the central nervous system (CNS) is the most serious consequence of

METHODS: To further address this issue, we implanted a cranial window on the cortex of B6.129P2(Cg)-

RESULTS AND DISCUSSION: We uncovered an early involvement of microglia that precedes invasion of the CNS by the parasite. We accomplished a detailed characterization of the progressive sequence of events that correlates with microglial morphological changes and microgliosis. Our findings unveiled a heterogeneous microglial response in places of initial homeostatic disruption near brain barriers and pointed out an exceptional capability of microglia to hamper parasite proliferation inside the brain. We …

A Novel Humanized Chi3l1 Blocking Antibody Attenuates Acetaminophen-Induced Liver Injury In Mice, Leike Li, Yankai Wen, Daniel Wrapp, Jongmin Jeong, Peng Zhao, Wei Xiong, Constance Lynn Atkins, Zhao Shan, Deng Hui, Jason S Mclellan, Ningyan Zhang, Cynthia Ju, Zhiqiang An

Faculty, Staff and Student Publications

Acetaminophen (APAP) overdose is a leading cause of acute liver injury in the USA. The chitinase 3-like-1 (Chi3l1) protein contributes to APAP-induced liver injury (AILI) by promoting hepatic platelet recruitment. Here, we report the development of a Chi3l1-targeting antibody as a potential therapy for AILI. By immunizing a rabbit successively with the human and mouse Chi3l1 proteins, we isolated cross-reactive monoclonal antibodies (mAbs) from single memory B cells. One of the human and mouse Chi3l1 cross-reactive mAbs was humanized and characterized in both

Disrupted Ca2+ Homeostasis And Immunodeficiency In Patients With Functional Ip3 Receptor Subtype 3 Defects, Julika Neumann, Erika Van Nieuwenhove, Lara E Terry, Frederik Staels, Taylor R Knebel, Kirsten Welkenhuyzen, Kourosh Ahmadzadeh, Mariah R Baker, Margaux Gerbaux, Mathijs Willemsen, John S Barber, Irina I Serysheva, Liesbeth De Waele, François Vermeulen, Susan Schlenner, Isabelle Meyts, David I Yule, Geert Bultynck, Rik Schrijvers, Stephanie Humblet-Baron, Adrian Liston

Faculty, Staff and Student Publications

Calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-operated calcium (Ca2+) entry resulting in severe immunodeficiency. The inositol 1,4,5-trisphosphate receptor (IP3R), a homo- or heterotetramer of the IP3R1-3 isoforms, amplifies lymphocyte signaling by releasing Ca2+ from endoplasmic reticulum stores following antigen stimulation. Although knockout of all IP3R isoforms in mice causes immunodeficiency, the seeming redundancy of the isoforms is thought to explain the absence of variants in human immunodeficiency. In this study, we identified compound heterozygous variants of ITPR3 (a gene encoding IP3R subtype 3) in two unrelated Caucasian patients presenting with immunodeficiency. To determine whether ITPR3 …

Open Treatments For Thoracoabdominal Aortic Aneurysm Repair, Akiko Tanaka, Holly N Smith, Hazim J Safi, Anthony L Estrera

Faculty, Staff and Student Publications

Thoracoabdominal aortic aneurysms (TAAA) represent a unique pathology that is associated with considerable mortality if untreated. While the advent of endovascular technologies has introduced new modalities for consideration, the mainstay of TAAA treatment remains open surgical repair. However, the optimal conduct of open TAAA repair requires careful consideration of patient risk factors and a collaborative team effort to mitigate the risk of perioperative complications. In this chapter, we briefly outline the history of treating TAAA, preoperative preparation and postoperative care, and our operative techniques for treatment.

Not Just A Pain: A Medical Simulation Case About Biased Communication And Osteomyelitis In Pediatric Sickle Cell Anemia, Adeola A Kosoko, Yakira R Alford, Karl A Upplegger, Gowri S Stevens

Faculty, Staff and Student Publications

Introduction

Biases in communication can be harmful to patient perceptions of care and the medical team's decision-making. Optimal communication must be taught and practiced similarly to the optimal management of the complex medical conditions associated with sickle cell disease (SCD). This simulation is designed to teach about biases, optimizing communication to and about a patient with SCD, and appropriately diagnosing and managing pediatric osteomyelitis as a complication of SCD.

Methods

We designed and implemented a simulation case targeting emergency medicine residents and fellows to raise awareness about biases associated with SCD care and the complication of osteomyelitis in children with …

Seizures, Vitamin D Deficiency, And Severe Hypophosphatemia: The Unique Presentation Of A Sars-Cov-2 Case, Benson Yeh, Christopher Bell, Christopher Anderson, Mack Sheraton

Faculty, Staff and Student Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to the species severe acute respiratory syndrome-related coronavirus (SARSr-CoV), which is related to the SARS-CoV-1 virus that caused the 2002-2004 SARS outbreak. SARS-CoV-2 causes coronavirus disease 2019 (COVID-19). It has been associated with electrolyte abnormalities. In this report, we discuss the case of a SARS-CoV-2-infected person presenting with recurrent seizure episodes resulting from hypophosphatemia. A 52-year-old male patient with questionable prior seizure history presented to the emergency department (ED) twice within eight days with recurring seizure episodes. While the physical examination at the first presentation was significant for …

Dysregulated Coagulation System Links To Inflammation In Diabetic Kidney Disease, Mengyun Xiao, Donge Tang, Shaodong Luan, Bo Hu, Wenyu Gong, Wolfgang Pommer, Yong Dai, Lianghong Yin

Faculty, Staff and Student Publications

Diabetic kidney disease (DKD) is a significant contributor to end-stage renal disease worldwide. Despite extensive research, the exact mechanisms responsible for its development remain incompletely understood. Notably, patients with diabetes and impaired kidney function exhibit a hypercoagulable state characterized by elevated levels of coagulation molecules in their plasma. Recent studies propose that coagulation molecules such as thrombin, fibrinogen, and platelets are interconnected with the complement system, giving rise to an inflammatory response that potentially accelerates the progression of DKD. Remarkably, investigations have shown that inhibiting the coagulation system may protect the kidneys in various animal models and clinical trials, suggesting …

Common Statistical Concepts In The Supervised Machine Learning Arena, Hooman H Rashidi, Samer Albahra, Scott Robertson, Nam K Tran, Bo Hu

Faculty, Staff and Student Publications

One of the core elements of Machine Learning (ML) is statistics and its embedded foundational rules and without its appropriate integration, ML as we know would not exist. Various aspects of ML platforms are based on statistical rules and most notably the end results of the ML model performance cannot be objectively assessed without appropriate statistical measurements. The scope of statistics within the ML realm is rather broad and cannot be adequately covered in a single review article. Therefore, here we will mainly focus on the common statistical concepts that pertain to supervised ML (i.e. classification and regression) along with …

Conformational Rearrangements In The Sensory Rcsf/Omp Complex Mediate Signal Transduction Across The Bacterial Cell Envelope, Sarah R Lach, Santosh Kumar, Seonghoon Kim, Wonpil Im, Anna Konovalova

Faculty, Staff and Student Publications

Timely detection and repair of envelope damage are paramount for bacterial survival. The Regulator of Capsule Synthesis (Rcs) stress response can transduce the stress signals across the multilayered gram-negative cell envelope to regulate gene expression in the cytoplasm. Previous studies defined the overall pathway, which begins with the sensory lipoprotein RcsF interacting with several outer membrane proteins (OMPs). RcsF can also interact with the periplasmic domain of the negative regulator IgaA, derepressing the downstream RcsCDB phosphorelay. However, how the RcsF/IgaA interaction is regulated at the molecular level to activate the signaling in response to stress remains poorly understood. In this …

U.S.-China Economic Links And Technological Decoupling, Kevin Zhang

Faculty Publications – Economics

The US has been waging an economic decoupling from China, in which national security concerns replace economic logic and loss-loss game replaces win-win gains from globalization. The decoupling is generating profound ramifications for the world as well as the US and China. The article explores the following questions: what drives the US government to implement the decoupling? what rationales for technology separation as the core of the decoupling? and what are possible outcomes of the decoupling in the short run and long run? It argues that (a) the decoupling was motivated mainly by national security and geopolitical concerns that China’s …

Comprehension, Diagram Analysis, Integration, And Interest: A Cross-Sectional Analysis, Courtney Hattan, Eunseo Lee, Alexandra List

Faculty Publications - College of Education

The current study examines a multidimensional set of outcome variables to understand whether different pre-reading scaffolds influence students’ text comprehension, diagram analysis, text integration, and interest; and investigates these constructs cross-sectionally to identify any progression as students move across grades. One-hundred fifty-six 3rd through 6th grade students enrolled in a public laboratory school were randomly assigned to one of three pre-reading conditions intended to activate or build students’ topic knowledge. Students completed a series of before, during, and after reading activities while engaging with grade appropriate texts about the topics of ecosystems and living things. Results indicate that there were …

Like A Pig In Mud: Rejecting The Manicured Boundaries Of The Patriarchy, S. Gavin Weiser, Lindsay Demartino, Alyssa Stasicky

Faculty Publications - College of Education

How do school leaders make sense of the mess of the regimes of the normal (Warner, 1993) when they themselves are beyond the norm? While we may be beyond the normal, we are also “awash in the flow of the everyday” (Manalansan, 2018, p. 2). Though we may resist and see ourselves as beyond the norm (Weiser et al., 2019), we are never “in a position of exteriority in relation” (Foucault, 1978, p. 95) to the norms of power. Using data from several different projects collected over the past several years, we conceptualize a new way to consider not only …

Childhood Acute Poisoning At Haiphong Children's Hospital: A 10-Year Retrospective Study, Sang Ngoc Nguyen, Lam Tung Vu, Ha Thai Nguyen, Le My Thi Nguyen

Faculty, Staff and Student Publications

INTRODUCTION: Children are most often harmed by acute poisoning, which may cause disability or even death. This demonstrates the critical necessity for epidemiologic studies specific to each nation and area since they aid in developing plans for the prevention of acute poisoning. There are no data or outdated data on acute poisoning in children in Vietnam. This research would partly fill this existing gap and compare the trend with other places across the globe.

METHODS: A retrospective study was conducted in the 10-year period from 2012 to 2021 in Haiphong Children's Hospital, Vietnam.

RESULTS: There were 771 children hospitalized due …

Exploring The Definition Of Resilience: A Convergent Parallel Mixed Methods Study In Adults Over The Age Of 65, Sara J. Blessington

Antioch University Dissertations & Theses

The definition of a word helps us understand its context and how it is meant to be used in daily life or research. When a word lacks a universal definition, it is hard to know how to use it. “Resilience” is that type of word. The resilience community in psychological research does not have a concrete, universal definition for this word. It takes on whatever characteristics are useful to the investigator. This study began with seeking a universal definition for the domain known as resilience. This study used a convergent parallel design with adults aged 60 and older living independently …

The Impact Of Poorly Facilitated Anti-Racist Conversations, Brandon Kirkwood

Antioch University Dissertations & Theses

It is well established that the graduate school experience is significantly different for students of color; on top of a rigorous training program, they face additional distinct challenges including racism, discrimination, and feelings of isolation. Insidious Trauma theory provides the framework for this quantitative exploration assessing the impact of poorly facilitated anti-racist conversations on the physical and emotional wellbeing of clinical psychology graduate students of color. George Floyd’s murder, among many other incidents of racial injustice, was a powerful catalyst that propelled academic institutions into action. Anti-racist dialogue became the intentional focus of graduate classes almost overnight. Well-meaning but insufficiently-prepared …

With Liberty And Justice For All: Psychological And Functional Consequences For Service Members Acquitted Of Sexual Assault, Jamie Leavey

Antioch University Dissertations & Theses

Policy makers are tasked with changing laws and improving systemic processes in response to evolving moral standards. As societal outrage grew regarding sexual assault in the military, those in power sought to balance what was perceived as a system that ignored, retaliated against, or unfairly burdened victims. However, as the pendulum swung toward victims’ rights and privileges, those accused of this crime inherited the burden of an imbalanced system. In the military context, the experience of the accused is impacted by the lack of separation between functional domains of life (e.g., work, home, community), multiple roles of military commanders (e.g., …

Examining The Relationship Between Non-Suicidal Self-Injury And Attachment Styles, Larissa Grundmanis

Antioch University Dissertations & Theses

Non-suicidal self-injury, or NSSI, can be defined as the “intentional, self-inflicted destruction of body tissue performed without suicidal intent using methods that are not socially sanctioned” (Martin et al., 2017, p. 425). Lifetime prevalence has been found to be between 5.9% and 18% (Cassels et al., 2019; Klonsky, 2011), indicating that there is a need to understand NSSI so that individuals can be helped to reduce the frequency of their harming behaviors. There is reason to believe that one’s attachment style is associated with the engagement of NSSI (e.g., Wrath & Adams, 2019). Research shows mixed results regarding the types …

Psychologist Perspectives On The Treatment And Assessment Of Problematic Sexual Behavior In Neurodivergent Youth, Emily R. Marhan

Antioch University Dissertations & Theses

The following dissertation explored the subjective experience of mental health clinicians regarding their perceptions of providing treatment and assessment to neurodivergent youth (ND) who exhibited problematic sexual behavior (PSB). Prior to this study, scant research has been conducted pertaining to the treatment and assessment of youth who exhibit PSB, and less still on those with comorbid neurodivergence (Jones & Chaplin, 2017; Malovic et al., 2016; Pratt, 2013). This study utilized Interpretative Phenomenological Analysis to inform interpretations of participant responses collected through semi-structured interviews. Participants consisted of five licensed psychologists with experience providing assessment and/or treatment to both neurotypical and ND …

Navigating Conflict During Periods Of Change In Higher Education: Deconstructing Academic Leaders’ Construction Of Meaning, Tyler Guy Olson

Antioch University Dissertations & Theses

Navigating departmental and organizational conflict is an essential function and responsibility of an academic unit leader (dean, associate dean, director, or chair) in higher education institutions (HEIs). During periods of organizational change, conflict tends to increase in complexity and difficulty—in part due to resistance to change—making it more difficult to manage in a constructive manner (Marcus, 2014). Much of the literature that looks at the academic unit leader and conflict focuses on personal conflict styles (or modes), types of conflicts encountered, and training on techniques and skills for conflict resolution and management. Missing from the literature is research that examines …

Living With Awareness, Courage, And Love: An Accessible Behavioral Intervention To Improve Well-Being, Emerson J. Hardebeck

Antioch University Dissertations & Theses

Accessing mental healthcare is difficult and has become more so as demand escalated during the ongoing COVID-19 pandemic. In an attempt to address this problem, an established behavior therapy, Functional Analytic Psychotherapy (FAP), has recently been adapted into a group-based format called Living with Awareness, Courage, and Love (ACL), which can be disseminated inexpensively and quickly due to its reliance on laypeople, rather than clinicians, as facilitators. This randomized-controlled trial evaluated the effects of a six-week ACL group on participants’ well-being across several domains. Compared to participants in the control group, those in the ACL intervention formed a significantly closer …

Binge Drinking And Protective Behavioral Strategies Among Greek And Non-Greek College Students, Maria Niitepold

Antioch University Dissertations & Theses

One of the most problematic habits of college students, binge drinking, has been of particular interest among researchers as a result of the increased risk of harm experienced by students engaging in this high-risk behavior. Fraternity and sorority students have also come under scrutiny for habitually engaging in binge drinking and experiencing significant levels of negative consequences as a result. Little is currently understood about the differences between Protective Behavioral Strategy (PBS) use of Greek and non-Greek students. The aim of this study was to examine the differences in rates of binge drinking and PBS use among Greek and non-Greek …

Towards An Ecosystem Of Youth Leadership Development, Trisha Swed

Antioch University Dissertations & Theses

This study is aimed at understanding how youth leadership development programs can be more inclusive and promote a broader range of leadership values, qualities, and behaviors by focusing on young people who have been disaffected by leadership development programs. The study design was intended to provide a creative space for youth to engage in meaningful conversations about their evolving concepts and expectations of leadership. Using critical youth participatory action research to engage a group of youth, cohort members co-created a new youth leadership development program while addressing their identified challenges and needs. Findings from this study highlight the importance of …

Empowered Presence: Theorizing An Afrocentric Performance Of Leadership By African American Women, Sharon Wamble-King

Antioch University Dissertations & Theses

There is a paucity of theorizing concerning leadership enactments performed by African American women. The performances have been marginalized and obscured within the Western leadership canon as they fall outside its epistemological boundaries; they have also been sidelined within Critical Leadership Studies. This study employed Afrocentricity as a decolonizing paradigm and Africology as the research methodology to describe and define a leadership phenomenon enacted by African American women. Setting aside Western conceptions of leadership, focus groups of African American women examined video excerpts of Africana women’s oral performances through an Africological lens. Participants’ Afrocentric-oriented perceptions sparked collective storytelling and Meaning-Making …

Internalized Transphobia And The Development Of Disordered Eating Behaviors In Gender Diverse Adults, Bonnie Kester

Antioch University Dissertations & Theses

Gender diverse individuals experience a multitude of oppressive interactions within our society and receive incessant messages of invalidation, oppression, and aggression. These chronic stressors have been shown to increase the risk of developing disordered eating behaviors within this population. The current study aims to explore how internalized transphobia may affect the development of disordered eating behavior as viewed through the Minority Stress Framework. This study explored the lived experience of being gender diverse in our society and how this may relate to the development of disordered eating behavior while also investigating protective factors. This study utilized a qualitative phenomenological methodology, …

Executive Functioning Among The Karyotypes In Turner Syndrome And Implications For Interventions, Sara Scull

Antioch University Dissertations & Theses

Turner syndrome (TS) is a genetic disorder seen in phenotypically female (pf) individuals who have either a complete or partial absence of the second sex (X) chromosome. TS includes different karyotypes, and it presents with a variety of phenotypic and genotypic features. In general, the neuropsychological profiles for individuals diagnosed suggest that TS can contribute to challenges in various aspects of daily life, including social and emotional functioning. With regard to academic performances, individuals with TS often present with relative strengths in a range of verbal abilities and relative weakness in visual-spatial/perceptual abilities, nonverbal memory, motor function, processing speed, executive …

Relationship Goals: How Do Relational Therapists Conceptualize Cases And Treatment Plan When Working With Consensually Non-Monogamous Clients?, Caitlyn Burns

Antioch University Dissertations & Theses

This study aimed to explore how relational therapists in the United States conceptualize cases and treatment plan when working with consensually non-monogamous clients and how dominant discourses about relationships (mononormativity) influence relational therapists during this process through a queer theory lens. This was a grounded theory study and surveyed a sample of thirty relational therapists or therapists-in- training. Results showed relational therapists conduct conceptualization and treatment planning through a two-part process. Therapists intend to treat CNM clients the same as any other client, but are unable to do so due to dominant discourses of mononormativity. Furthermore, mononormative discourses influenced relational …