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Melittin: A Natural Component Of Honeybee Venom As A Potential Anti-Cancer Therapy, Niamh Donnellan, Anne M. Friel

SURE Journal: Science Undergraduate Research Experience Journal

Cancer is a major cause of death worldwide and while chemotherapy is the main approach there are many negative associations in current treatment procedures. These include lack of selectivity, side effects and drug resistance. The hallmarks of cancer are a fundamental concept which aids the development of new means to treat human cancers through the understanding of the acquisition of these hallmarks from cells.

Melittin is a major peptide component of bee venom which has shown to be efficacious as an anticancer agent in preclinical and animal models. Melittin has many biological functions including pore formation in the phospholipid bilayer …

To What Extent Does Labor Force Participation Empower Women?, Karolin H. Lehmann

Journal of International Women's Studies

This paper critically examines the relationship between women’s labor force participation (LFP) and empowerment, particularly in the Global South, utilizing Naila Kabeer’s empowerment framework. By challenging the orthodox conceptualization of LFP, the study reveals its methodological limitations as a measure of women’s economic engagement. By emphasizing the dynamic nature of empowerment as a multifaceted process within the formal and informal sector, this paper highlights the interplay of agency, resources, and achievements within Kabeer’s framework. Drawing from global examples, it demonstrates the varied impacts of paid work on women’s decision-making in both private and public spheres. While acknowledging the potential of …

Feminist Biology: Towards Gender Equity In The Biology Curriculum, Nicole Danos, Carla Y. Bonilla, Sofia Leung

Feminist Pedagogy

The current curriculum in STEM is a product of historically unequal representation of genders in the science community. As a result, most attention has been given to male biology, creating a knowledge gap that has affected our social and political perspectives, such as an underinvestment in women’s health research. Feminist biology seeks to provide equal time and weight to the impact of sex as a biological factor, using inclusive definitions of biological sex that go beyond the male/female binary. Feminist pedagogy is a method of teaching that involves engaged learning and reflection in order to create a community of learners …

Creating Meaningful Connections With The Electron Transport Chain Beyond A Virtual Classroom, Lesley-Ann Giddings

Feminist Pedagogy

At the center of feminist pedagogy is community. Creating community within the classroom and between the class and local communities increases student engagement and access to knowledge. Communities can be a source of solidarity and further decenter authority in the classroom, empowering students, teachers, and the surrounding community to be co-learners. Amid the COVID-19 pandemic, remote teaching posed challenges to student engagement. Here, I describe an assignment used to build an inclusive community of co-learners within a virtual biochemistry class and our local communities. Oxidative phosphorylation is a cellular process used to create energy that depends on the electron transport …

The Effects Of Volcanic Deposits On Human Preservation, Charles M. Nuncio

Culture, Society, and Praxis

No abstract provided.

The Retirement Of Chief Justice Frank F. Drowota, Iii: A Tribute To A Legal Legend And All Around Nice Guy, Lisa Rippy, Marshall Davidson

Tennessee Journal of Law and Policy

No abstract provided.

Non-Fungible Tokens (Nfts) - Survey Of Current Applications, Evolution And Future Directions, Qaiser Razi, Aryan Devrani, Harshal Abhyankar, Gss Chalapathi, Vikas Hassija, Mohsen Guizani

Machine Learning Faculty Publications

Non-fungible tokens (NFTs) have become an exciting technology that provides a fresh perspective on asset ownership, provenance, and value exchange. NFTs, a blockchain-based technology, are distinct and indivisible cryptographic tokens used to confirm and record the ownership of digital and physical assets in an immutable and transparent way. The fundamental block of NFT is a smart contract built on a blockchain network. This contract contains specific information about the asset it represents, such as its unique identifier, metadata, and ownership details. The information is kept private and tamper-proof due to the decentralized and distributed structure of the blockchain, boosting faith …

Migranthood: Youth In A New Era Of Deportation, James Loucky

Maya America: Journal of Essays, Commentary, and Analysis

Book Review Migranthood: Youth in a New Era of Deportation Lauren Heidbrink Stanford University Press, 2020. 240p.

Complete Issue: Volume 5 Issue 2, Maya America Editors

Maya America: Journal of Essays, Commentary, and Analysis

The full Issue 2, Volume 5 of Maya America, published December 2023

Request For An Advisory Opinion On Climate Emergency And Human Rights By The Republic Of Colombia And The Republic Of Chile, Diane A. Desierto, Francisco Urbina, Aníbal Pérez-Liñán, Nicolas Buitrago Rey, Faisal Yamil Meneses, Garrett Pacholl

Court Briefs

The Notre Dame Law School Human Rights Clinic (NDLS GHRC) in collaboration with the Notre Dame Reparations Design and Compliance Lab (ND Reparations Lab)

From the Introduction

Noting the request of the Republic of Colombia and the Republic of Chile for this Honorable Court to "provide guidance towards human rights-based solutions with an intersectional perspective," this Expert Opinion deliberately draws on interdisciplinary methods that weave international law, international human rights law, jurisprudence, quantitative tools of political science, and qualitative tools of social science research to assist this Honorable Court in its task of addressing the manifold questions brought by the …

Nucleus Accumbens Core Single Cell Ensembles Bidirectionally Respond To Experienced Versus Observed Aversive Events, Oyku Dinckol, Noah Harris Wenger, Jennifer E Zachry, Munir Gunes Kutlu

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Fear learning is a critical feature of survival skills among mammals. In rodents, fear learning manifests itself through direct experience of the aversive event or social transmission of aversive stimuli such as observing and acting on conspecifics' distress. The neuronal network underlying the social transmission of information largely overlaps with the brain regions that mediate behavioral responses to aversive and rewarding stimuli. In this study, we recorded single cell activity patterns of nucleus accumbens (NAc) core neurons using in vivo optical imaging of calcium transients via miniature scopes. This cutting-edge imaging methodology not only allows us to record activity patterns …

“This Is The Psychology We Need”: Maya Immigrant Views On Mental Health Treatment, Robin Chancer

Maya America: Journal of Essays, Commentary, and Analysis

This paper engages the theme of psychological-physical-spiritual health among displaced Maya communities. To pursue knowledge about the communities’ visions for thriving in the United States, I worked with Maya leaders in Ohio to coordinate a series of dialogues utilizing a Participatory Action Research paradigm. Participants exposed ways in which Western institutions (including hospitals, mental health providers, and schools) reenact elements of colonialism and fail to offer culturally sensitive care. The participants emphasized a key missing element in their well-being: renewing the relationship with the Earth that they lost through colonization and forced migration. To separate physical/mental health from these elements …

La Creación De Una Civilización: Arquitectos, Dibujantes E Ingenieros A Finales Del Siglo Xviii Y Principios Del Siglo Xix En La Provincia De Chiapa, Omar López Espinosa

Maya America: Journal of Essays, Commentary, and Analysis

El artículo se enfoca en el papel protagónico que tuvieron algunos arquitectos, dibujantes e ingenieros en la producción de las primeras imágenes de una ciudad abandonada en el extremo norte de la selva de la Provincia de Chiapa, conocida como las Casas de Piedra (hoy nombrada Palenque). El propósito del escrito es mostrar la relevancia que tuvieron esos dibujos en la discusión sobre los primeros pobladores de América, al ser recuperados por algunos editores/anticuaristas como Henry Berthould (1822), Lord Kinsborough (1831), Henry Baranderé (1834) o Brasseur de Bourbourg (1866) en la primera mitad del siglo XIX. Estos personajes dieron a …

Distance From A Cultural Model Of Substance Use Risk, Internalization, And Self-Stigma In Urban Brazil, Nicole L. Henderson, William W. Dressler, Natalia Priolli Jora Pegoraro, Ana Falcao, Sandra Cristin Pillon

APC Fund

Introduction: A cognitive theory of culture as socially distributed cultural models has proven useful in research. Cultural models exist in two forms: the model shared by individuals in a social group, and individual versions of that model modified by personal experience. In previous research we documented a shared cultural model of substance use risk among a general population sample in urban Brazil. Here we examine how this model is distributed among persons under treatment for substance use/misuse and the implications for perceived and self-stigma.

Methods: A convenience sample of 133 persons under treatment rated the influence of risk factors for …

Intracellular Negative Feedback Mechanisms In Blubber And Muscle Moderate Acute Stress Responses In Fasting Seals, Jessica G. Avalos, Elizabeth R. Piotrowski, Allison D. Northey, Daniel E. Crocker, Jane I. Khudyakov

Pacific Faculty Work

Animals may limit the cost of stress responses during key life history stages such as breeding and molting by reducing tissue sensitivity to energy-mobilizing stress hormones (e.g. cortisol). We measured expression of genes encoding glucocorticoid receptor (GR, NR3C1), GR inhibitor (FKBP5) and cortisol-inactivating enzyme (HSD11B2) in blubber and muscle of northern elephant seals before and after stress axis stimulation by adrenocorticotropic hormone (ACTH) early and late in a fasting period associated with molting. ACTH elevated cortisol levels for >24 h and increased FKBP5 and HSD11B2 expression while downregulating NR3C1 expression in blubber and muscle, suggesting robust intracellular negative feedback in …

High-Throughput Deconvolution Of 3d Organoid Dynamics At Cellular Resolution For Cancer Pharmacology With Cellos., Patience Mukashyaka, Pooja A Kumar, David J Mellert, Shadae Nicholas, Javad Noorbakhsh, Mattia Brugiolo, Elise T Courtois, Olga Anczuków, Edison Liu, Jeffrey Chuang

Faculty Research 2023

Three-dimensional (3D) organoid cultures are flexible systems to interrogate cellular growth, morphology, multicellular spatial architecture, and cellular interactions in response to treatment. However, computational methods for analysis of 3D organoids with sufficiently high-throughput and cellular resolution are needed. Here we report Cellos, an accurate, high-throughput pipeline for 3D organoid segmentation using classical algorithms and nuclear segmentation using a trained Stardist-3D convolutional neural network. To evaluate Cellos, we analyze ~100,000 organoids with ~2.35 million cells from multiple treatment experiments. Cellos segments dye-stained or fluorescently-labeled nuclei and accurately distinguishes distinct labeled cell populations within organoids. Cellos can recapitulate traditional luminescence-based drug response …

Physically And Chemically‑Crosslinked L‑Arginine‑Loaded Polyvinyl Alcohol‑ Hyaluronic Acid‑ Cellulose Nanocrystals Hydrogel Membranes For Wound Healing: Influence Of Crosslinking Methods On Biological Performance Of Membranes In‑Vitro, Elbadawy A. Kamoun, Elbadawy A. Kamoun

Nanotechnology Research Centre

Two types of polyvinyl alcohol-blended hyaluronic acid and cellulose nanocrystals (PVA/HA/CNCs) hydrogels membranes were developed as delivery agents for L-arginine using chemical/and/physical crosslinking methods for exploring biological performance of the obtained membranes. Chemically and physically/crosslinked membranes were fabricated by solution-casting and freeze-thawing techniques, respectively. The characterization of the crosslinked PVA/HA/CNCs/Larginine membranes were conducted by SEM, FTIR, TGA, swelling ratio, and in—vitro L-arginine release. Furthermore, applying two types of crosslinked membranes in vitro were investigated in terms of cytotoxicity, hemocompatibility, and cell adhesion affinity of HFB-4 cell line. Chemical and physical-crosslinked membranes were verified through the esterification and hydrogen bonds interactions, …

The Contested Exempla Of Lucius Cornelius Sulla, Victoria Theresa White

Dissertations and Theses

In 82 BCE, Lucius Cornelius Sulla emerged the victor of his civil war against the supporters of Marius and Cinna. The brutal aftermath of this victory, characterized by the creation of the proscriptions, would brand Sulla as a cruel and immoderate victor. Still, his successes in Rome’s previous wars against foreign enemies had enshrined Sulla as a brilliant military commander within Roman memory. Previous scholarship about Sulla has focused on the dichotomy of Sulla’s actions, often in order to evaluate his clemency or cruelty and his aims of his political reforms. This thesis analyzes how ancient Roman and Greek authors …

Sports Medicine Research And Testing Laboratory, Petitioner V. Board Of Equalization Of Salt Lake County, State Of Utah, And Utah State Tax Commission, Respondents., Utah Supreme Court

Utah Supreme Court Briefs (2021– )

Brief of Respondent Utah State Tax Commission On Petition for Review of a Final Decision of the Utah State Tax Commission, Appeal No. 20-1618

Samuel A. Lambert Bruce Olson RAY QUINNEY & NEBEKER P.C. Attorneys for Petitioner Sports Medicine Research and Testing Laboratory

Erin T. Middleton (10666) Assistant Solicitor General Michelle Lombardi (14085) Assistant Attorney General Sean D. Reyes (7969) Utah Attorney General Attorneys for Respondent Utah State Tax Commission

Denied, Disrespected, Doubted, And Discarded: Women's Criminal Convictions And Experiences Of Discrimination, Brian Wyant, Holly Harner, Brian Lockwood

Midwest Social Sciences Journal

This study surveyed over 400 incarcerated women in a medium-maximum security prison in the United States to assess their experiences of discrimination due to their criminal conviction. Over 60% of the participants indicated they had been discriminated against due to their felon status. Binary logistic models revealed that discrimination based on prison status can occur both inside and outside of prison but varies by race and length of stay. Similarly, qualitative results showed that during and after their incarceration, these women reported being denied jobs, disrespected and viewed as incapable of changing. Some women even anticipated they would experience discrimination …

Mechanical Characterization Of Vertically Aligned Carbon Nanotube Forest Microelectrodes For Neural Interfacing, Spencer Mcleod Roberts

Theses and Dissertations

Silicon intracortical microelectrodes arrays (MEA) provide some of the best performance for brain computer interfaces but suffer from lifetime limitations that prevent clinical adoption. A primary contributor of lifetime limitations is the chronic foreign body response (FBR) which remains active in response to the brain tissue strain caused by implanted probes during brain micromotion. Designing probes with softer materials can reduce the chronic FBR and improve device lifetime. A high-aspect ratio CNT MEA could provide several advantages as an intracortical MEA but has yet to be mechanically characterized. CNT MEAs are infiltrated with 3 degrees of carbon infiltration and mechanically …

Reclaiming Sacred Homelands: Asserting Treaty Rights And The Path Towards Restoration Of The Badger-Two Medicine, Sarah Greenberg

American Indian Law Journal

“In order for law to have an influence in the lives of ordinary people, it must have something to do with the emotional feelings of justice, it must speak to our basic humanity, and it must give us common sense directions as to what behavior and beliefs are right and wrong"

Understanding The Impact Of Pedagogical Changes In An Honors Activism Course: A Case Study, Aaron Peeksmease

UNL Faculty Course Portfolios

The purpose of this portfolio is to document learning outcomes after initiating three pedagogical changes in an Honors Sociology of Activism course taught at UNL in both the Fall of 2022 and Fall of 2023. The first change was to provide students with prior student work of an assignment to see if student performance on the assignment improved. Findings indicated that providing examples of previous student work did not raise grades on the overall assignment, but did result in stronger projects for that one aspect of the overall assignment. The second change examined the impact of introducing reading quizzes and …

Seeking Higher Ground: Developing A Tribal Model Code For Disaster And Emergency Management In A Complex Jurisdictional Environment, Brian Candelaria

American Indian Law Journal

“The teepee is much better to live in;

always clean, warm in winter, cool in summer; easy to move. The white man builds his big house, cost much money, like big cage, shut out sun, can never move; always sick. Indians and animals know better how to live than white man; nobody can be in good health if does not have all the time fresh air, sunshine, and good water.”

- Chief Flying Hawk[1]

In 2019, I opened my submission for the Sovereignty Symposium’s Doolin Award with the statement above. The entry was accepted and reprinted in the American …

Pathway Centric Analysis For Single-Cell Rna-Seq And Spatial Transcriptomics Data With Gsdensity, Qingnan Liang, Yuefan Huang, Shan He, Ken Chen

Faculty, Staff and Student Publications

Advances in single-cell technology have enabled molecular dissection of heterogeneous biospecimens at unprecedented scales and resolutions. Cluster-centric approaches are widely applied in analyzing single-cell data, however they have limited power in dissecting and interpreting highly heterogenous, dynamically evolving data. Here, we present GSDensity, a graph-modeling approach that allows users to obtain pathway-centric interpretation and dissection of single-cell and spatial transcriptomics (ST) data without performing clustering. Using pathway gene sets, we show that GSDensity can accurately detect biologically distinct cells and reveal novel cell-pathway associations ignored by existing methods. Moreover, GSDensity, combined with trajectory analysis can identify curated pathways that are …

Determining The Quality Of Sugar Beet Pulp, Lenox, And Ryegrass Silages Used In Feeding Dairy Cattle, In Comparison To Corn Silage, Fatma Özkan, Suphi̇ Deni̇z

Turkish Journal of Veterinary & Animal Sciences

This study was carried out to determine the quality of sugar beet pulp (Beta vulgaris L.), lenox (Brassica rapa L.), and ryegrass (Lolium multiflorium cv. caramba) silages used in feeding dairy cattle, in comparison to corn silage. Whole corn was harvested at the dough stage, lenox was harvested at the end of flowering, and ryegrass was harvested at the beginning of spike. No additives were added to the corn silage, but 5% molasses was added to the sugar beet pulp, ryegrass, and lenox silages that have low levels of easily degradable sugar. Additionally, 5% sainfoin was added to the sugar …

Noninvasive Pregnancy Detection In Wild Felids Using Enzyme Immunoassay Of Fecal 13, 14–Dihydro–15–Keto–Pgf2Α Metabolite (Pgfm), Nikitha Prakash, Suchitra Bhadravathi Raju, Sahadev Annayappa, Leena Gowda, Veena Malavalli Prabhushankar

Turkish Journal of Veterinary & Animal Sciences

The study was carried out on Panthera species (4 lions and 5 tigers) housed in Bannerghatta Biological Park, Bengaluru, and Sri Chamarajendra Zoological Gardens, Mysuru. Estrus behavior such as rolling, licking, nudging, chuffing, frequent urination, whitish discharge, vocalisation, lordosis and copulatory behavior such as vocalisation, allowed to be mounted, aggression towards male, mounting, and biting of the nape of female were exhibited both in lions and tigers which helped to identify the time of fecal sample collection. The study’s main aim was to carry out noninvasive and noncontact pregnancy detection in these wild felids. Feces samples collected from the female …

Investigation Of Three Single-Nucleotide Polymorphisms (1252 G>A, 2534 G>A, And 2569 T>C) Of The Mbl1 Gene In Anatolian Buffaloes, Esma Gamze Aksel, Bi̇lal Akyüz

Turkish Journal of Veterinary & Animal Sciences

It has been reported that since the MBL gene is involved in the first step of infection and inflammation processes, it may be associated with susceptibility to bacterial and viral diseases in living organisms. In this study, it was aimed to determine the genotypic variation of Anatolian buffaloes in terms of three (1252G>A, 2534 G>A, and 2569 T>C) single nucleotide polymorphisms (SNPs) within the MBL-1 gene. For this purpose, 103 Anatolian buffaloes were genotyped for relevant SNPs by PCR-RFLP process. The allele and genotype frequencies of the examined samples were determined, and the population was examined for …

Effect Of Thermo-Insulated Kid Hutch On Location Preference, Growth Performance, And Blood Haemato-Biochemical Indices Of Winter-Born Goat Kids (Capra Hircus), Ajoy Das, Dilip Kumar Mandal, Asish Debbarma, Muthupalani Karunakaran, Anupam Chatterjee, Debajyoti Sarkar

Turkish Journal of Veterinary & Animal Sciences

This study assessed the effect of thermo-insulated kid hutch (TIKH) on location preference, body surface temperature, growth performance, and blood haemato-biochemical indices of winter-born Black Bengal goat kids. Does were maintained in the same shed, born kids (n = 12) were divided into two groups along with mothers to begin experiments from day 1 of birth. The treatment group (TIKH) of kids was given a TIKH to which kids had free access, but not the adults. However, in the control group (CONT) kids were reared without TIKH. The floor surface temperature of TIKH was significantly (p < 0.05) higher at night as compared to goat shed in December (4.28%), January (3.98%), and February (7.72%). The interior roof surface of TIKH had 25.12%, 33.55%, 31.85%, 10.99%, and 4.37% higher (p < 0.01) temperatures at night compared to the roof surface temperature of the goat shed in December, January, February, March, and April, respectively. The presence of kids inside the TIKH at the age of 1–15 days was the greatest in morning (80.5%) and evening (72.2%). Between the ages of 16–-60 days, the preference of kids for the TIKH varied from 69.2% to 54.2% in the morning and from 70.0% to 66.7% in the evening. However, at the age of 61–75 days, kids’ preference for TIKH gradually declined in the morning (11.6%) and evening (19.9%) due to the increased inside temperature. Kids weaning weight was 23.25% higher (p < 0.05) in the TIKH group as compared to that of CONT. The average daily gain (0–30 days) was higher (41.34%; p < 0.05) in kids in the TIKH compared to the CONT shed. The haemato-biochemical profiles of kids were similar in both groups except for blood serum glucose, which was greater (p < 0.05) in kids of the TIKH than that of CONT shed. In conclusion, the provision of TIKH improved the growth and overall performance of winter-born Black Bengal goat kids during pre and postweaning periods.

Water Buffalo Social Networks During Their Activities On Pasture Under The Rain, Eleni Tsiobani, Maria Yiakoulaki, Nikolaos Hasanagas, Ioannis Antoniou

Turkish Journal of Veterinary & Animal Sciences

Water buffaloes exhibit various social structures during their activities on pasture, but the impact of abiotic factors (i.e. rainfall) on these structures remains unknown. While existing research has provided evidence concerning the effect of weather conditions on grazing animals’ behavior, they have not examined how animals differentiate their social organization within the herd during their activities on pasture under the rainfall. This study utilized social network analysis to construct, depict, and analyze the proximity networks among buffaloes in each activity they perform on pasture before, during, and after the rainfall. By applying various network indices, we have shown that water …