Digital Commons Network^™

A Mathematical Model Of Acanthocephalan Parasite Infection In Gull-Billed Terns, Charlotte Moser

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Editor's Note, Jessica Heybach

Education and Culture

No abstract provided.

Comparative Analysis Of Swine Antibody Responses Following Vaccination With Live-Attenuated And Killed African Swine Fever Virus Vaccines, Hung Q. Luong, Huong T. L. Lai, Lam Q. Truong, The N. Nguyen, Hanh D. Vu, Hoa T. Nguyen, Lan T. Nguyen, Trang H. Pham, David Scott Mcvey, Hiep Vu

Nebraska Center for Virology: Faculty Publications

African swine fever virus (ASFV) is circulating in many swine-producing countries, causing significant economic losses. It is observed that pigs experimentally vaccinated with a live-attenuated virus (LAV) but not a killed virus (KV) vaccine develop solid homologous protective immunity. The objective of this study was to comparatively analyze antibody profiles between pigs vaccinated with an LAV vaccine and those vaccinated with a KV vaccine to identify potential markers of vaccineinduced protection. Thirty ASFV seronegative pigs were divided into three groups: Group 1 received a single dose of an experimental LAV, Group 2 received two doses of an experimental KV vaccine, …

The Student Movement Volume 108 Issue 7: Not Throwing Away Our Shot: Honoring Hamilton's Legacy, Anneliese Tessalee, Nick Bishop, Grace No, Madison Vath, Amelia Stefanescu, Katrina Johnson, Reagan Mccain, Andrew Francis, Melissa Moore, Brendan Oh, Abby Shim, Reagan Westerman, Robert Zhang, Nicole Compton-Gray, Katie Davis, Anna Rybachek, Rodney Bell Ii, Wambui Karanja

The Student Movement v. 108 (2023-2024)

HUMANS

An Arboretum of Beauty, Anneliese Tessalee

Serving with All She's Got: Natalia's Mission Experience in the Dominican Republic, Nick Bishop

WAUS Fall Fundraiser, Grace No

ARTS & ENTERTAINMENT

Art: A Window Into Another Reality, Madison Vath

Filipino Art Through Filipino Eyes: Celebrating A Culture, Amelia Stefanescu

"Free-Falling Into Autumn": A Fall Playlist, Amelia Stefanescu

Upcoming Events in the Art Department, Katrina Johnson

What to do about Inhospitality?: A Review of Mitski's Newest Album, Reagan McCain

NEWS

Andrews Autumn Conference Promotes Peaceful Scientific Discourse, Andrew Francis

Honors Goes to Hamilton, Melissa Moore

Unraveling the Historical Threads: The SDA Church's Journey …

Suffolk Journal, Vol.87, No. 6, 11/03/2023, Suffolk Journal

Suffolk Journal

No abstract provided.

The Bison, November 3, 2023

The Bison Newspapers

No abstract provided.

Digital Libraries As Digital Third Place: Virtual Programming In The Age Of Loneliness, Stephen Craig Finlay, Jenny Haddon

Criss Library Faculty Proceedings & Presentations

Brick-and-mortar libraries are commonly cited as examples of “third places:” community building spaces outside of home and work which embody qualities of equity and access without placing demands upon those who use them. However, as libraries increasingly invest in digital services, can they continue to serve in that role through virtual programming? Amid what public health officials are currently referring to as a “loneliness epidemic,” with the highest self-reported rates of loneliness and social isolation measured since sociologists began tracking it in the 1970s, the community-building role of libraries is perhaps more essential than ever. While much has been written …

Repurposing Egfr Inhibitors For Oral Cancer Pain And Opioid Tolerance, Maria Daniela Santi, Morgan Zhang, Naijiang Liu, Chi T Viet, Tongxin Xie, Dane D Jensen, Moran Amit, Huilin Pan, Yi Ye

Faculty, Staff and Student Publications

Oral cancer pain remains a significant public health concern. Despite the development of improved treatments, pain continues to be a debilitating clinical feature of the disease, leading to reduced oral mobility and diminished quality of life. Opioids are the gold standard treatment for moderate-to-severe oral cancer pain; however, chronic opioid administration leads to hyperalgesia, tolerance, and dependence. The aim of this review is to present accumulating evidence that epidermal growth factor receptor (EGFR) signaling, often dysregulated in cancer, is also an emerging signaling pathway critically involved in pain and opioid tolerance. We presented preclinical and clinical data to demonstrate how …

2023-11-03 Agenda Book, Morehead State University. Board Of Regents.

Morehead State Board of Regents Agenda Books and Meeting Minutes

Agenda booklet for the Board of Regents meeting of November 3, 2023 which includes the meeting minutes of August 18, 2023.

Formal Concept Analysis For Image Classification And Machine Learning Models For Anti-Crispr Protein Discovery In Bioinformatics, Minal Khatri

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This study investigates two critical areas in bioinformatics: enhancing transparency in medical image analysis and advancing the discovery of Anti-CRISPR (Acr) proteins, which have potential in developing more precise and controlled CRISPR-Cas gene editing tools. While CNN’s are increasingly applied in critical fields like medical diagnosis, understanding their decision-making process remains a challenge. Although visualization techniques like Saliency maps offer insights into CNN’s decision-making for individual images, they do not explicitly establish a relationship between the high-level features learned by CNN’s and the class labels across dataset. To bridge this gap, Formal Concept Analysis (FCA) framework is leveraged as a …

Access Of Persons With Disabilities To Public Ground Transportation And Roadways, Marya Aldoukhi, Molly Angel, Libby Bare, Daniel Blacher, Jillian Cawi, Tristan Chabanel, Mark Ciccone, Kaitlyn Clapper, Salim El Jai, Andrew Ferrer, Patricio Figueroa, Karissa Fraticelli, Billy Freudenthal, Mandy Glime, Megha Gupta, Isabella Henley, Jacob Hill, Erika Huber, Anders Johnson, Mae Kinst, Arthur Klein, Tori Litz, Benjamin Lussier, Vincenzo Mazur, Maggie Mcgee, Alexander Memmer, Lindsey Anoubon Momo, Madison Mullens, Nelly Ngei, Shivani Pulugura, Matt Rach, Brandon Ruge, Navya Sachdev, Kiernan Schuerman, Elizabeth Schulz, Moyo Shobowale, Reagan Smiley, Jiahui Song, Jett Stad, Crosley Stanley, Braden Stock, Matthew Van Kooten, Elyse Zurawski, Bradley S. Duerstock, Juan C. Mesa

Undergraduate Coursework

No abstract provided.

Glutamate Receptor Dysregulation And Platelet Glutamate Dynamics In Alzheimer's And Parkinson's Diseases: Insights Into Current Medications, Deepa Gautam, Ulhas Naik, Meghna Naik, Santosh Yadav, Rameshwar Nath Chaurasia, Debabrata Dash

Cardeza Foundation for Hematologic Research

Two of the most prevalent neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and Parkinson's disease (PD), present significant challenges to healthcare systems worldwide. While the etiologies of AD and PD differ, both diseases share commonalities in synaptic dysfunction, thereby focusing attention on the role of neurotransmitters. The possible functions that platelets may play in neurodegenerative illnesses including PD and AD are becoming more acknowledged. In AD, platelets have been investigated for their ability to generate amyloid-ß (Aß) peptides, contributing to the formation of neurotoxic plaques. Moreover, platelets are considered biomarkers for early AD diagnosis. In PD, platelets have been studied for …

Mutual Emotional Labor As Method: Building Connections Of Care In Qualitative Research, Jill A. Fisher, Torin Monahan

The Qualitative Report

Emotional labor may be vital to the success of qualitative research studies, particularly longitudinal studies that depend on the maintenance of research relationships over time. Rather than being limited to the comportment of researchers toward their participants, however, we find that participants also actively engage in practices of emotional labor to manage researchers and guide research interactions. We document elements of such “mutual emotional labor” in the establishment of rapport, in crafting experiences of personalized therapeutic benefit from participating in interviews, and in efforts to navigate closure at the conclusion of research projects. We argue that by recognizing forms of …

Virtual Delivery Of Stress Management And Resiliency Training (Smart) During The Covid-19 Pandemic To Hematology/Oncology Fellows: A Pilot Study, Colt Williams, Sherry Chesak, Deirdre R. Pachman, Ross Dierkhising, Laura Rhee, Konstantinos Leventakos

Journal of Wellness

Introduction: Medical trainees experience a high degree of stress that predisposes them to burnout. This pilot study tested a scalable approach to deliver a validated resilience program (Stress Management and Resiliency Training (SMART)) among Hematology/Oncology fellows at an academic medical center.

Methods: This was a mixed-methods, prospective, single-arm clinical trial involving Hematology/Oncology fellows at Mayo Clinic in Rochester, MN, USA. Four one-hour training sessions were conducted virtually with 26 fellows. Stress, burnout, and emotional resilience were measured at baseline, three months, and six months post-intervention using the Perceived Stress Scale (PSS-10), Maslach Burnout Inventory (MBI-HSS), and Connor-Davidson Resilience …

China Maritime Report No. 32: The Pch191 Modular Long-Range Rocket Launcher: Reshaping The Pla Army's Role In A Cross-Strait Campaign, Joshua Arostegui

CMSI China Maritime Reports

With its fielding of the PCH191 multiple rocket launcher (MRL) and its variety of long-range precision munitions, the PLA Army (PLAA) has become arguably the most important contributor of campaign and tactical firepower during a joint island landing campaign against Taiwan. No longer simply the primary source of amphibious and air assault forces, the PLAA is now capable of using its multiple battalions of PCH191 MRLs to support maritime dominance, the joint firepower strike, and ground forces landing on Taiwan’s shores and in depth. The Chinese ordnance industry has developed multiple low-cost rockets, an anti-ship cruise missile, and a tactical …

Discovery, Structure-Activity Relationship And In Vitro Anticancer Activity Of Small-Molecule Inhibitors Of The Protein-Protein Interactions Between Af9/Enl And Af4 Or Dot1l, Xin Li, Xiaowei Wu, Shenyou Nie, Jidong Zhao, Yuan Yao, Fangrui Wu, Chandra Bhushan Mishra, Md Ashraf-Uz-Zaman, Bala Krishna Moku, Yongcheng Song

Faculty, Staff and Students Publications

Simple Summary

Chromosomal translocations involving the mixed lineage leukemia (MLL) gene generate potent fusion oncogenes and cause acute myeloid leukemia or lymphocytic leukemia, which account for ~75% infant and 5–10% child/adult acute leukemia cases with a poor prognosis (5-year survival rates < 45%). Protein–protein interactions between the most frequent MLL fusion partner proteins AF9/ENL and AF4 or histone methyltransferase DOT1L are critical to malignant gene expression and are therefore a potential drug target for cancer. Compound screening followed by medicinal chemistry studies identified several novel small-molecule inhibitors showing strong inhibition of these protein–protein interactions, significant suppression of characteristic gene expression, and robust cellular anticancer activities with negligible cytotoxicity. These compounds are useful chemical probes for biological studies of these protein–protein interactions, as well as pharmacological leads for further drug development against MLL-rearranged and other leukemias.

Abstract

Chromosomal translocations involving the mixed lineage leukemia (MLL) gene cause 5–10% acute leukemias with poor clinical outcomes. Protein–protein interactions (PPI) between the most frequent MLL fusion partner proteins AF9/ENL and AF4 or histone methyltransferase DOT1L are drug targets for MLL-rearranged (MLL-r) leukemia. Several benzothiophene-carboxamide compounds were identified as novel inhibitors of these PPIs with IC₅₀ values as …

Diagnostic And Commensal Staphylococcus Pseudintermedius Genomes Reveal Niche Adaptation Through Parallel Selection Of Defense Mechanisms, Sanjam S Sawhney, Rhiannon C Vargas, Meghan A Wallace, Carol E Muenks, Brian V Lubbers, Stephanie A Fritz, Carey-Ann D Burnham, Gautam Dantas

2020-Current year OA Pubs

Staphylococcus pseudintermedius is historically understood as a prevalent commensal and pathogen of dogs, though modern clinical diagnostics reveal an expanded host-range that includes humans. It remains unclear whether differentiation across S. pseudintermedius populations is driven primarily by niche-type or host-species. We sequenced 501 diagnostic and commensal isolates from a hospital, veterinary diagnostic laboratory, and within households in the American Midwest, and performed a comparative genomics investigation contrasting human diagnostic, animal diagnostic, human colonizing, pet colonizing, and household-surface S. pseudintermedius isolates. Though indistinguishable by core and accessory gene architecture, diagnostic isolates harbor more encoded and phenotypic resistance, whereas colonizing and surface …

Brain Metastasis-Associated Fibroblasts Secrete Fucosylated Pvr/Cd155 That Induces Breast Cancer Invasion, Emma Adhikari

USF Tampa Graduate Theses and Dissertations

Breast cancer (BC) continues to be the most diagnosed cancer and the second leading cause of cancer deaths in women worldwide. High mortality, in most cancers, is due to metastasis; BC is the most common source of one of the deadliest forms of metastasis–brain metastasis (BM) in female. Patients with triple negative breast cancer (TNBC) exhibit the highest incidence of BM and poorest survival outcomes upon diagnosis with BM. The prognosis of breast cancer brain metastasis (BCBM) remains poor because the blood–brain barrier (BBB) prevents the uptake of drug substances, including chemotherapeutic agents, targeted agents, and toxins, from the brain. …

Integrated Periphyton Biofilters In Marine Recirculating Aquaculture Systems, Adam N. Bell

USF Tampa Graduate Theses and Dissertations

Marine aquaculture is a growing industry that has the potential to reduce eutrophication, overfishing, and loss of biodiversity. Recirculating aquaculture systems (RAS) are a type of aquaculture system that decreases discharge, raises biological control, and conserves water; however, RAS are challenged due to high energy cost, low biodiversity, water quality control, and waste nutrients. Periphyton biofilters are a new technology that allows for feed production, water quality control, microbial diversity, and resource recovery in marine aquaculture systems. The overarching question that this dissertation investigates is, how can periphyton biofilters be integrated into RAS to address the challenges of modern sustainable …

Oregon State Rank Assessment For Klamath Lamprey (Lampetra Similis), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Klamath Lamprey (Lampetra similis) using NatureServe methodology, 2023.

Oregon State Rank Assessment For Pit-Klamath Brook Lamprey (Entosphenus Lethophagus), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Pit-Klamath brook lamprey (Entosphenus lethophagus) using NatureServe methodology, 2023.

Oregon State Rank Assessment For Umpqua Dace (Rhinichthys Evermanni), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Umatilla dace (Rhinichthys evermanni) using NatureServe methodology, 2023.

Neglected Tropical Disease Vaccines: Hookworm, Leishmaniasis, And Schistosomiasis, Peter J Hotez, Maria Elena Bottazzi, Paul M Kaye, Bruce Y Lee, Karl Philipp Puchner

Faculty, Staff and Students Publications

No abstract provided.

A Retrospective Analysis Of Hyperlipidemia And Covid-19 Outcomes Investigated In A Rural Midwestern Population, Rachel Steffes, Sydney Christensen, Laura Schreck, Nova Beyersdorfer, Darrin S. Goade, Kerry Johnson, Greg Stahl, Nicole R. Ford, Robert Arnce

Student Publications

Background

COVID-19 is a respiratory disease caused by SARS-CoV-2, a coronavirus discovered in 2019. Its impact on the world continues to be studied due to the significant death toll of the disease. As the COVID-19 pandemic remains ongoing, examining the association of COVID-19 with comorbidities and resulting mortality is necessary. This study focuses on population health outcomes with COVID-19 infection and hyperlipidemia (total cholesterol greater than or equal to 200 mg/dL) as a comorbidity, including potential associations with age and sex.

Methods

As a retrospective analytical study, patients were divided into three populations based on COVID-19 and/or hyperlipidemia based on …

Unc-49 Is A Redox-Sensitive Gabaa Receptor That Regulates The Mitochondrial Unfolded Protein Response Cell Nonautonomously, Franziska Pohl, Allison L Germann, Jack Mao, Sydney Hou, Bayode Bakare, Paul Kong Thoo Lin, Kyari Yates, Michael L Nonet, Gustav Akk, Kerry Kornfeld, Jason M Held

2020-Current year OA Pubs

The γ-aminobutyric acid-mediated (GABAergic) system participates in many aspects of organismal physiology and disease, including proteostasis, neuronal dysfunction, and life-span extension. Many of these phenotypes are also regulated by reactive oxygen species (ROS), but the redox mechanisms linking the GABAergic system to these phenotypes are not well defined. Here, we report that GABAergic redox signaling cell nonautonomously activates many stress response pathways in

Repeated, Short Cold-Water Immersions Are Sufficient To Habituate To The Cold, But Do Not Lead To Adaptations During Exercise In Normobaric Hypoxia, Geoffrey T. Dorsett, Trevor L. Gillum

International Journal of Exercise Science: Conference Proceedings

Cold and hypoxia naturally exist together, yet it is unknown if habituation to the cold can lead to improved exercise in hypoxia. PURPOSE: To assess the effects of repeated cold-water immersions (CWI) on pulmonary, metabolic, and sympathoadrenal responses to graded exercise in hypoxia. METHODS: 16 (2 female) participants (age: 21.2 ± 1.3 years; body fat: 12.3 ± 7.7 %; body surface area 1.87 ± 0.16 m², VO_2peak: 48.7 ± 7.9 mL/kg/min) underwent 6 CWI in 12.0 ± 1.2° C. Each CWI was 5 minutes, twice daily, separated by ≥4 hours, for 3 consecutive days, …

In The Beginning: Rousseau’S Discourse On The Origin Of Inequality & The Socialist Book Of Genesis, Steven Kessler

Journal of Ideology

The following article makes the connection between the work and thought of Jean-Jacques Rousseau and socialism. Rousseau invalidated the concept of original sin where God punished man with labor. Not only did he invalidate original sin in his personal life, but he went a step further: he invalidated the entire creation myth from the Book of Genesis. Rousseau then supplanted that creation myth with his own origin story, one he outlined in great detail in an essay called, This Discourse on the Origin of Inequality. This work contains the creation myth of socialism, and is the socialist book of …

Integrating Traditional Culltural Expressions (Tce) And Indigenous Traditional Knowledge Sysetms (Tk) In Social And Economic Policy For Sustainable Development, Stanislas Bigirimana

Biennial Conference: The Social Practice of Human Rights

Intellectual property contributes to Sustainable Development Goals (SDGs) in various ways. Most African economies are based on extractive industries. This creates a situation where developing economies are suppliers of raw materials to industrialized economies and importers of manufactured goods. Intellectual property coupled with an increased awareness of the importance of intellectual capital and intangible assets creates a situation where Africans and other developing economies are realizing that natural resources alone are not really wealth. There is a need for value addition and beneficiation of natural resources. There are good initiatives such as the development of the automobile industry in Ghana …

Phenotypic Correlations Between Enteric Methane Emissions And Feeding Behaviour Traits In Beef Cattle, Sean Crowley

ORBioM (Open Research BioSciences Meeting)

Background

Animal breeding for methane mitigation offers the unique potential to make cumulative and permanent improvements, setting it apart from nutritional or management strategies that require ongoing investment. Internationally multiple phenotypes for enteric methane emissions have been defined, however the complexity of the relationship between methane and feed intake and ultimately animal performance, has meant there has been little consensus on which methane definition should be used in breeding goals.

Aims

Previous enteric methane research focused on traditional methane metrics like yield, intensity and residual emissions, leaving a gap in understanding how alternative traits, such as feeding behaviour, impact methane …

Bactericidal Effects Of Chlorine And Bacteriophages On Mycobacteria In Conventionally Treated Water., Max Kevane-Campbell

ORBioM (Open Research BioSciences Meeting)

Introduction

Mycobacteria are members of the order Actinomycetales and the only genus in the family Mycobacteriaceae. The distinguishing characteristics that are found in mycobacteria include acid-fastness and the presence of mycolic acids. Mycobacteria can be commonly classified as non-spore-forming, aerobic, slender rod-shaped, and are slow-growers. Natural reservoirs that mycobacteria can be found in are aquatic and terrestrial environments. Recent studies have shown that mycobacteria that can cause skin lesions, immune and/or pulmonary dysfunctions and chronic diseases, i.e., Mycobacterium avium subsp. Paratuberculosis, M. kansasii, and M. xenopi, can be isolated from common household tap water. Tap water can originate from …