Digital Commons Network^™

Strong Correlations Of Sea Ice Cover With Macroalgal Cover Along The Antarctic Peninsula: Ramifications For Present And Future Benthic Communities, Charles D. Amsler, Margaret O. Amsler, Andrew Klein, Aaron W. Galloway, Katrin Iken, James B. Mcclintock, Sabrina Heiser, Alex T. Lowe, Julie Schram, Ross Whippo

Faculty, Staff, and Students

Macroalgal forests dominate shallow hard bottom areas along the northern portion of the Western Antarctic Peninsula (WAP). Macroalgal biomass and diversity are known to be dramatically lower in the southern WAP and at similar latitudes around Antarctica, but few reports detail the distributions of macroalgae or associated macroinvertebrates in the central WAP. We used satellite imagery to identify 14 sites differing in sea ice coverage but similar in terms of turbidity along the central WAP. Fleshy macroalgal cover was strongly, negatively correlated with ice concentration, but there was no significant correlation between macroinvertebrate cover and sea ice. Overall community (all …

Tim-3 Blockade In Diffuse Intrinsic Pontine Glioma Models Promotes Tumor Regression And Antitumor Immune Memory., Iker Ausejo-Mauleon, Sara Labiano, Daniel De La Nava, Virginia Laspidea, Marta Zalacain, Lucía Marrodán, Marc García-Moure, Marisol González-Huarriz, Irati Hervás-Corpión, Laasya Dhandapani, Silvestre Vicent, Maria Collantes, Iván Peñuelas, Oren J. Becher, Mariella G. Filbin, Li Jiang, Jenna Labelle, Carlos A O De Biagi-Junior, Javad Nazarian, Sandra Laternser, Timothy N. Phoenix, Jasper Van Der Lugt, Mariette Kranendonk, Raoull Hoogendijk, Sabine Mueller, Carlos De Andrea, Ana C. Anderson, Elizabeth Guruceaga, Carl Koschmann, Viveka Nand Yadav, Jaime Gállego Pérez-Larraya, Ana Patiño-García, Fernando Pastor, Marta M. Alonso

Manuscripts, Articles, Book Chapters and Other Papers

Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain stem tumor and the leading cause of pediatric cancer-related death. To date, these tumors remain incurable, underscoring the need for efficacious therapies. In this study, we demonstrate that the immune checkpoint TIM-3 (HAVCR2) is highly expressed in both tumor cells and microenvironmental cells, mainly microglia and macrophages, in DIPG. We show that inhibition of TIM-3 in syngeneic models of DIPG prolongs survival and produces long-term survivors free of disease that harbor immune memory. This antitumor effect is driven by the direct effect of TIM-3 inhibition in tumor cells, the coordinated action …

Plastics And The Environment, I. E. Napper, R. C. Thompson

School of Biological and Marine Sciences

Plastics are persistent and pervasive throughout the environment and have now been reported from the deepest parts of the ocean to the tops of the highest and most remote mountains. There is a body of information on the sources, degradation, and transport of plastics as well as a variety of research investigating the ecotoxicological and wider ecological consequences of plastic ingestion and accumulation. Such knowledge has been obtained with developments in field and laboratory methods for plastic identification and then well-publicized in the media and wider public communications. However, although there has been a large focus on plastic pollution within …

The Echo: November 13, 2023, Taylor University

2023-2024 (Volume 111)

No abstract provided.

Harmonization Of Multi-Site Diffusion Tensor Imaging Data For Cervical And Thoracic Spinal Cord At 1.5 T And 3 T Using Longitudinal Combat, Devon M. Middleton, Yutong Li, Andrew Chen, Russell Shinohara, Joshua Fisher, Laura Krisa, Mark Elliot, Scott H. Faro, John H. Woo, Adam E. Flanders, Feroze B. Mohamed

Department of Radiology Faculty Papers

MRI scanner hardware, field strengths, and sequence parameters are major variables in diffusion studies of the spinal cord. Reliability between scanners is not well known, particularly for the thoracic cord. DTI data was collected for the entire cervical and thoracic spinal cord in thirty healthy adult subjects with different MR vendors and field strengths. DTI metrics were extracted and averaged for all slices within each vertebral level. Metrics were examined for variability and then harmonized using longitudinal ComBat (longComBat). Four scanners were used: Siemens 3 T Prisma, Siemens 1.5 T Avanto, Philips 3 T Ingenia, Philips 1.5 T Achieva. Average …

Cost Analysis Of Adsorption Based Air Capture Of Co2, Mona Muzammil, Muzammil Arshad, Muazzam Arshad

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Carbon dioxide (CO2) capture and conversion to value added products, such as chemicals, polymers, and carbon-based fuels represents a promising approach to transform a potential threat to the environment into a value-added product for long term sustainability. Emerging Carbon Capture Technologies: Towards a Sustainable Future provides a multidisciplinary view of the research that is being carried out in this field, covering materials and processes for CO2 capture and utilization and including a broad discussion of the impact of novel technologies in carbon capture on the energy landscape, society and climate. Of interest to students, researchers and professionals in industries related …

The George-Anne Reflector Magazine Newsletter, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Lanthorn, Vol. 58, No. 07, November 13, 2023, Grand Valley State University

Volume 58, August 7, 2023 - April 15, 2024

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Do Animals Deserve Moral Consideration?, Philosopher's Discussion Group

The Philosopher's Stone

• Do Animals Deserve Moral Consideration?

Chimes: November 13, 2023, Calvin University

Chimes

Faculty and students say dialogue, educaton about Israel-Hamas war necessary by Ethan Meyers & Savannah Shustack

Beyond the talking stage: Governance review begins implementation by Grace Buller & Ethan Meyers

Calvin posts positive student engagement survey results by Savannah Shustack

Calvin grad and professor publish study on re-entry services in West Michigan by Grace Buller

Calvin's DI and DIII hockey teams: What's the difference? by Dillion Baumchen Grace Buller

Founder of Calvin's chemical engineering concentration reflects on the program's beginnings by Jacob Westra

The Knightly: Interview with Pastor Mary by Lauren Nyong

I'm grateful for press freedom at Calvin by …

The Structures And Functions Of Offices Of Academic Affairs: A Case Study, Ryan Thomas Landry

LSU Doctoral Dissertations

This study sought to describe how offices of academic affairs (administrative offices supporting provosts) at public, research-intensive universities in the United States are structured and what kind of work these offices do. There is a dearth of scholarly literature on the topic, indicative of an overall lack of knowledge about these organizations. From a practical standpoint, I intended for this study to contribute to the body of knowledge of higher education administration with hopes that it provides helpful insights to administrators as they consider organizational design. Using the theoretical framework of modern organization theory, I employed an embedded case study …

A Cre-Dependent Massively Parallel Reporter Assay Allows For Cell-Type Specific Assessment Of The Functional Effects Of Non-Coding Elements In Vivo, Tomas Lagunas Jr, Stephen P Plassmeyer, Anthony D Fischer, Ryan Z Friedman, Michael A Rieger, Din Selmanovic, Simona Sarafinovska, Yvette K Sol, Michael J Kasper, Stuart B Fass, Alessandra F Aguilar Lucero, Joon-Yong An, Stephan J Sanders, Barak A Cohen, Joseph D Dougherty

2020-Current year OA Pubs

The function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with psychiatric diseases these would ideally be studied in neurons in a living brain. Massively Parallel Reporter Assays (MPRAs) are molecular genetic tools that enable functional screening of hundreds of predefined sequences in a single experiment. These assays have not yet been adapted to query specific cell types in vivo in a complex tissue like the mouse brain. Here, using a test-case 3'UTR MPRA library with genomic elements containing variants from autism patients, we developed a method to achieve …

Brown Anole (Anolis Sagrei) Hoxa5: Insights Into The Divergence Of Hoxa5 Gene Expression And Regulation Across Evolutionarily Divergent Gnathostome Vertebrates, Jennifer A. Lange, Amber L. Rittgers, Adam Davis

Georgia Journal of Science

Hox genes are evolutionarily conserved developmental regulatory genes that function, in part, to pattern the anterior-posterior (AP) axis of organs and organ systems during animal embryonic development. Hoxa5, specifically, is shown to be expressed in the spinal cord, somites, or transient compartments giving rise to the vertebrae and ribs, developing gut, lungs, and limbs of the mouse (Mus musculus). The cis-regulatory elements (CREs), or short DNA sequences, that direct Hoxa5 expression in these embryonic domains have been mapped and functionally tested in the mouse as well. Similar Hoxa5 expression patterns have been observed in chicken ( …

Improving The Thermal Comfort Of Industrial Building Using Insulation Materials, Hosam Amr, Androw Khairy

Journal of Engineering Research

industrial buildings are one of the larges used t worldwide, and every day it grows noticeably in many different forms of projects so , the introduction of insulation materials was very essential, and their development for enhancing a variety of parameters such as thermal comfort inside the building which became one of the very important aspects in industrial buildings. Design of any industrial building should be to the lowest cost keeping in consideration importance of thermal comfort and its contribution in the productivity improvement of the workers as well as the administrative employee as well as reducing the high costs …

Improving The Thermal Comfort Of Industrial Building Using Insulation Materials, Hosam Amr, Androw Khairy

Journal of Engineering Research

industrial buildings are one of the larges used t worldwide, and every day it grows noticeably in many different forms of projects so , the introduction of insulation materials was very essential, and their development for enhancing a variety of parameters such as thermal comfort inside the building which became one of the very important aspects in industrial buildings. Design of any industrial building should be to the lowest cost keeping in consideration importance of thermal comfort and its contribution in the productivity improvement of the workers as well as the administrative employee as well as reducing the high costs …

Relational Environmental Governance: A Critical Framework For Praxis With The Material World, Miles Kenny-Lazar, Adrienne Johnson, Farhana Sultana, Matthew Himley, Anthony Bebbington, Elizabeth Havice, Jennifer L. Rice, Tracey Osborne

Geography and the Environment - All Scholarship

Environmental governance (EG) has become a hegemonic concept for understanding and transforming environmental decision-making processes that operate beyond the state. However, political ecologists, drawing from a diverse set of theoretical frameworks, have critiqued the concept for being malleable, vague, and apolitical, which has enabled its appropriation in ways that conceal inequality and difference, advocate techno-managerial fixes, and espouse neoliberal solutions. Political ecologists have approached EG more critically with the conceptual tools of neoliberal natures, environmental regulation, and eco-governmentality. In this article, we contend that these conceptualizations, while theoretically rich, are limited in their capacity to capture a diversity of governance …

Usp38 Exacerbates Atrial Inflammation, Fibrosis, And Susceptibility To Atrial Fibrillation After Myocardial Infarction In Mice, Yang Gong, Tingting Yu, Wei Shuai, Tao Chen, Jingjing Zhang, He Huang

Faculty, Staff and Student Publications

BACKGROUND: Inflammation plays an important role in the pathogenesis of atrial fibrillation (AF) after myocardial infarction (MI). The role of USP38, a member of the ubiquitin-specific protease family, on MI-induced atrial inflammation, fibrosis, and associated AF is unclear.

METHODS: In this study, we surgically constructed a mouse MI model using USP38 cardiac conditional knockout (USP38-CKO) and cardiac-specific overexpression (USP38-TG) mice and applied biochemical, histological, electrophysiological characterization and molecular biology to investigate the effects of USP38 on atrial inflammation, fibrosis, and AF and its mechanisms.

RESULTS: Our results revealed that USP38-CKO attenuates atrial inflammation, thereby ameliorating fibrosis, and abnormal electrophysiologic properties, …

Microplastics In Different Tissues Of A Commonly Consumed Fish, Mohammad Belal Hossain, Farjana Haque Pingki, Md Abdus Samad Azad, As-Ad Ujjaman Nur, Partho Banik, Bilal Ahamad Paray, Takaomi Arai, Jimmy Yu

Faculty, Staff and Student Publications

Microplastics (MPs) ingestion by fish signifies a worldwide threat to human health but limited research has examined their existence within the consumable portions (muscle) of fish. Thus, this study was undertaken to unveil the prevalence, characterization, and contamination extent of MPs across various body tissues, including the muscle of the king mackerel (S. guttatus) from the lower Meghna estuary in Bangladesh-a pioneering investigation in this region. In our analysis, we identified a total of 487 MPs, with an average abundance of 48.7 ± 20.3 MPs/individual. These MPs were distributed across different tissues, with respective concentrations of 0.84 ± …

Single-Cell Analysis Differentiates The Effects Of P53 Mutation And P53 Loss On Cell Compositions Of Oncogenic Kras-Driven Pancreatic Cancer, Xinlei Sun, Daowei Yang, Yang Chen

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignant disease with a dismal prognosis. In the past decades, a plethora of genetically engineered mouse models (GEMMs) with autochthonous pancreatic tumor development have greatly facilitated studies of pancreatic cancer. Commonly used GEMMs of PDAC often harbor the oncogenic KRAS driver mutation (KrasG12D), in combination with either p53 mutation by knock-in strategy (Trp53R172H) or p53 loss by conditional knockout (Trp53cKO) strategy, in pancreatic cell lineages. However, the systematic comparison of the tumor microenvironment between KrasG12D; Trp53R172H (KPmut) mouse models and KrasG12D; Trp53cKO (KPloss) mouse models …

Racism As A Threat To Financial Stability, Cary Martin Shelby

Northwestern University Law Review

This Article draws from several theoretical frameworks such as critical race theory, law and economics, and rule of law conceptions to argue that the Financial Stability Oversight Council (FSOC) should formally recognize racism as a threat to financial stability due to its interconnectedness with recent and projected systemic disruptions. This Article begins by first introducing a novel model created by the author through which to dissect this claim. This “Systemic Disruption Model” provides a theoretical depiction of how racism drives every phase along the life-cycle continuum of a systemic disruption.

First, with respect to the Model’s “Introduction” phase, this Article …

Climate Change, Corruption, And Colonialism: Solving The Conundrum With Regional Courts, Taylor Nchako

Northwestern University Law Review

It is no secret that climate change is the most pressing issue of our times. Global South countries, especially those in Africa, face challenges mitigating the worst impacts of climate change, adapting technological solutions, and continuing to develop their nation’s infrastructure and industry. Cameroon provides an archetypal example of the challenges many African countries face. Plagued by an economy that both exacerbates climate change and stands to collapse from it, Cameroon struggles with corruption that has roots in colonialism and neocolonialism. This corruption taints not only the forestry service and the executive branch, but the judiciary as well, leaving Cameroon’s …

Jenna Wagner, Soprano

Bailey School of Music Concert Programs

Jenna Wagner, Soprano

Eric Jenkins, Piano

November 11th, 2023

5:30p.m. | Music Building 109 Recital Hall

Emily Epperly, Violin

Bailey School of Music Concert Programs

Emily Epperly, violin

Dr. Eric Jenkins

November 11, 2023

3:00, Morgan Hall

Ecological Change And Livestock Governance In A Peruvian National Park, Kenneth R. Young, Eyner Alata, Rodney Chimner, Randall B. Boone, Gillian Bowser, Laura Bourgeau-Chavez, Beatriz Fuentealba, Jessica Gilbert, Javier A. Ñaupari, Molly H. Polk, Sigrid Resh, Cecilia Turin, Melody Zarria-Samanamud

Michigan Tech Publications

While the grazing of livestock has occurred for millennia in the Andes, current sustainability debates center on concerns with co-managing climate change and pastoralism. These discussions have special resonance in places protected by the state for biodiversity, scenery, and sustainable and traditional land uses, such as those found in protected areas and biosphere reserves. For this article, we integrate data from a social-ecological research project on the land use systems that affect high-elevation ecosystems in Peru’s Huascarán National Park, with special emphasis on the wetlands. We used land cover and land use data and insights from interactions with pastoralists to …

Integrated Flood Risk Assessment Of Properties And Associated Population At County Scale For Nebraska, Usa, Shivendra Srivastava, Tirthankar Roy

Department of Civil and Environmental Engineering: Faculty Publications

Risk assessment of properties and associated population was conducted for the state of Nebraska, leveraging only open-source datasets. The flood risk framework consisted of interactions among drivers, i.e. hazard, exposure, vulnerability, and response, to assess the risks related to properties and associated populations. To quantify hazard on a county scale, we considered properties at risk of flooding based on a flood score (a higher score represents a greater chance of flooding). Exposure was quantified by considering population density at the county level. We quantified vulnerability under four categories: social, ecological, economic, and health. Response, a relatively newer component in flood …

Integrated Flood Risk Assessment Of Properties And Associated Population At County Scale For Nebraska, Usa, Shivendra Srivastava, Tirthankar Roy

Department of Civil and Environmental Engineering: Faculty Publications

Risk assessment of properties and associated population was conducted for the state of Nebraska, leveraging only open-source datasets. The flood risk framework consisted of interactions among drivers, i.e. hazard, exposure, vulnerability, and response, to assess the risks related to properties and associated populations. To quantify hazard on a county scale, we considered properties at risk of flooding based on a flood score (a higher score represents a greater chance of flooding). Exposure was quantified by considering population density at the county level. We quantified vulnerability under four categories: social, ecological, economic, and health. Response, a relatively newer component in flood …

The Importance Of A Healthy Microbiome In Pregnancy And Infancy And Microbiota Treatment To Reverse Dysbiosis For Improved Health, Herbert L Dupont, Madeleine Mary Hines Salge

Faculty, Staff and Student Publications

BACKGROUND: The microbiome of newborn infants during the first 1000 days, influenced early on by their mothers' microbiome health, mode of delivery and breast feeding, orchestrates the education and programming of the infant's immune system and determines in large part the general health of the infant for years.

METHODS: PubMed was reviewed for maternal infant microbiome health and microbiota therapy in this setting with prebiotics, probiotics, vaginal seeding and fecal microbiota transplantation (FMT).

RESULTS: A healthy nonobese mother, vaginal delivery and strict breast feeding contribute to microbiome health in a newborn and young infant. With reduced microbiome diversity (dysbiosis) during …

Increase In Hnrnpa1 Expression Suffices To Kill Motor Neurons In Transgenic Rats, Xionghao Liu, Tingting Zhang, Qinxue Wu, Cao Huang, Xu-Gang Xia, Hongxia Zhou, Bo Huang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

A dominant mutation in hnRNPA1 causes amyotrophic lateral sclerosis (ALS), but it is not known whether this mutation leads to motor neuron death through increased or decreased function. To elucidate the relationship between pathogenic hnRNPA1 mutation and its native function, we created novel transgenic rats that overexpressed wildtype rat hnRNPA1 exclusively in motor neurons. This targeted expression of wildtype hnRNPA1 caused severe motor neuron loss and subsequent denervation muscle atrophy in transgenic rats that recapitulated the characteristics of ALS. These findings demonstrate that the augmentation of hnRNPA1 expression suffices to trigger motor neuron degeneration and the manifestation of ALS-like phenotypes. …

Targeting The Αvβ3/Ngr2 Pathway In Neuroendocrine Prostate Cancer, Anna Testa, Fabio Quaglia, Nicole M. Naranjo, Cecilia E. Verrillo, Christopher D. Shields, Stephen Lin, Maxwell W. Pickles, Drini F. Hamza, Tami Von Schalscha, David A. Cheresh, Benjamin E Leiby, Qin Liu, Jianyi Ding, William K. Kelly, D. Craig Hooper, Eva Corey, Edward F. Plow, Dario C. Altieri, Lucia R. Languino

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Highly aggressive, metastatic, neuroendocrine prostate cancer, which typically develops from prostate cancer cells acquiring resistance to androgen deprivation therapy, is associated with limited treatment options and hence poor prognosis. We have previously demonstrated that the αVβ3 integrin is over-expressed in neuroendocrine prostate cancer. We now show that LM609, a monoclonal antibody that specifically targets the human αVβ3 integrin, hinders the growth of neuroendocrine prostate cancer patient-derived xenografts in vivo. Our group has recently identified a novel αVβ3 integrin binding partner, NgR2, responsible for regulating the expression of neuroendocrine markers and for inducing neuroendocrine differentiation in prostate cancer cells. Through in …

Oregon State Ranking Assessment For Columbia Pebblesnail (Fluminicola Fuscus), Misty Nelson

Institute for Natural Resources Publications

Oregon State Ranking Assessment for Columbia pebblesnail (Fluminicola fuscus) by the Oregon Biodiversity Information Center, following NatureServe 2023 methodology.