Digital Commons Network^™

Analyzing Major Elements Of Crash Injury Severity Involving Priority-I Detriments Of Vision-Zero Plan, Muhammad Umer Farooq, Cole Madson, Aemal Khattak

Mid-America Transportation Center: Final Reports and Technical Briefs

Road traffic crashes result in significant economic losses for individuals, their families, and entire nations. These losses stem from the expenses associated with injury treatment, as well as the productivity lost due to fatalities or disabilities caused by these injuries. The 2030 Agenda for Sustainable Development set an ambitious target of halving the global number of fatalities and injuries from road traffic crashes by 2020 and achieving zero deaths by 2030, commonly referred to as the 'Target Zero Plan.' The Target Zero Plan prioritizes traffic safety issues into three distinct levels. The three priority levels are determined based on the …

Blue Runner (Caranx Crysos) Neurocranium, Delaney Deinlein, Gabriel Droz, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from approximately 30 cm total length (TL) Blue Runner (Caranx crysos), collected from Dania Pier in 2023 by Charles Klinger.

Oregon State Rank Assesment For Johnson's Hairstreak (Callophrys Johnsoni), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Johnson's hairstreak (Callophrys johnsoni) using NatureServe methodology, 2023.

Dietary L-Tryptophan Consumption Determines The Number Of Colonic Regulatory T Cells And Susceptibility To Colitis Via Gpr15, Nguyen Van, Karen Zhang, Rachel Wigmore, Anne Kennedy, Carolina Dasilva, Jialing Huang, Manju Ambelil, Jose Villagomez, Gerald O'Connor, Randy Longman, Miao Cao, Adam Snook, Michael Platten, Gerard Kasenty, Luis Sigal, George C Prendergast, Sangwon Kim

Department of Microbiology and Immunology Faculty Papers

Environmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain unclear. Here, we discover that the amount of consumed L-Tryptophan (L-Trp), a ubiquitous dietary component, determines the transcription level of the colonic T cell homing receptor, GPR15, hence affecting the number of colonic FOXP3⁺ regulatory T (Treg) cells and local immune homeostasis. Ingested L-Trp is converted by host IDO1/2 enzymes, but not by gut microbiota, to compounds that induce GPR15 transcription preferentially in Treg cells via the aryl hydrocarbon receptor. Consequently, two weeks of dietary L-Trp supplementation nearly double …

Functional Aggregation Of Cell-Free Proteins Enables Fungal Ice Nucleation, Ralph Schwidetzky, Ingrid De Almeida Ribeiro, Nadine Bothen, Anna T. Backes, Arthur L. Devries, Mischa Bonn, Janine Fröhlich-Nowoisky, Valeria Molinero, Konrad Meister

Chemistry and Biochemistry Faculty Publications and Presentations

Biological ice nucleation plays a key role in the survival of cold-adapted organisms. Several species of bacteria, fungi, and insects produce ice nucleators (INs) that enable ice formation at temperatures above −10 °C. Bacteria and fungi produce particularly potent INs that can promote water crystallization above −5 °C. Bacterial INs consist of extended protein units that aggregate to achieve superior functionality. Despite decades of research, the nature and identity of fungal INs remain elusive. Here, we combine ice nucleation measurements, physicochemical characterization, numerical modeling, and nucleation theory to shed light on the size and nature of the INs from the …

Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation, Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang

USF Patents

Disclosed herein are compounds that can prevent and treat C. difficile by inhibiting sporulation. Also disclosed herein are compositions and formulations comprising the compound disclosed herein. Methods of preventing and treating C. difficile comprising administering the compounds described herein are also disclosed.

Mirna As Systemic Mediators For Environmentally Persistent Free Radical-Induced Cardiovascular Dysfunction, Ankit Aryal

LSU Doctoral Dissertations

Air pollution is consistently linked with elevations in cardiovascular disease (CVD) and its mortality. Particulate matter (PM) is a pivotal factor in air pollution-associated CVD. PM containing environmentally persistent free radicals (EPFR) forms from the incomplete combustion of organic wastes. These products adhere to particulate matter carrying redox-active transition metals on its surface. To enable systematic research of the health impacts of EPFR, our colleagues developed a combustion method to produce EPFR-containing PM that closely resemble urban PM and validated their use for typical laboratory settings. We exposed mice to laboratory generated EPFR through whole-body inhalation and investigated their dose-dependent …

Impact Of Audio-Visually Enhanced Pedagogy On Student Performance And Satisfaction In The Blended Anatomy And Physiology Classroom, Pradeepa Poudyal

Graduate Theses, Dissertations, and Capstones

Demand for Anatomy and Physiology (AP) courses is increasing with the popularity of health care professions in the United States. Institutions are adopting blended mode of delivery in AP classes for its practicality. This mode allows implementation of multimodal pedagogy in the curriculum. Hence, students get to choose the resource that matches their learning preferences; understanding student needs is instrumental in enhancing learning experiences in any course. This study aimed to assess the impact of audio-visual interactive media (AVIM) on performance and satisfaction in the virtual lectures of blended AP courses. This study was conducted in two blended AP courses …

Colsa Grad Student Leads 'Day As A Scientist' Event For Manchester High Schoolers, Keith Testa

UNH Today Archive

No abstract provided.

Copyright 2023 Giarikos Et Al. Distributed Under Creative Commons Cc-By 4.0 Open Access Assessing The Ecological Risk Of Heavy Metal Sediment Contamination From Port Everglades Florida Usa, Dimitri Giarikos, Laura White, Andre M. Daniels, Radleigh Santos, Paul Baldauf, Amy Hirons

SECLER Data

Port sediments are often contaminated with metals and organic compounds from anthropogenic sources. Remobilization of sediment during a planned expansion of Port Everglades near Fort Lauderdale, Florida (USA) has the potential to harm adjacent benthic communities, including coral reefs. Twelve sediment cores were collected from four Port Everglades sites and a control site; surface sediment was collected at two nearby coral reef sites. Sediment cores, sampled every 5 cm, were analyzed for 14 heavy metals using inductively coupled plasma-mass spectrometry. Results for all three locations yielded concentration ranges (mg/g): As, Cd, Cr, Co, Cu, Pb, Mn, Hg, Mn, Ni, Se, …

The Effects Of The Big-Headed Turtle (Platysternon Megacephalum) On Community And Ecosystem In Hong Kong Hill Streams, Wing Lam Fok

Lingnan Theses (MPhil & PhD)

Freshwater turtles and tortoises are ecologically important organisms; however, they are underappreciated, and conservation attention often focuses on the more charismatic animals such as birds and mammals. Although turtles are the most traded group of animals and many species are at the brink of extinction, little research has been done to understand their ecology in Asia because of the rarity of wild populations. Hong Kong is a biodiversity hotspot for freshwater turtle species. The Big-headed Turtle (Platysternon megacephalum) is a critically endangered species that still maintains small populations in Hong Kong, providing a rare opportunity to study the …

Spartan Daily, November 14, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 161, Issue 36

Dhodh: A Promising Target In The Treatment Of T-Cell Acute Lymphoblastic Leukemia, Amy N Sexauer, Gabriela Alexe, Karin Gustafsson, Elizabeth Zanetakos, Jelena Milosevic, Mary Ayres, Varsha Gandhi, Yana Pikman, Kimberly Stegmaier, David B Sykes

Faculty, Staff and Student Publications

Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) have a poor prognosis with few therapeutic options. With the goal of identifying novel therapeutic targets, we used data from the Dependency Map project to identify dihydroorotate dehydrogenase (DHODH) as one of the top metabolic dependencies in T-ALL. DHODH catalyzes the fourth step of de novo pyrimidine nucleotide synthesis. Small molecule inhibition of DHODH rapidly leads to the depletion of intracellular pyrimidine pools and forces cells to rely on extracellular salvage. In the absence of sufficient salvage, this intracellular nucleotide starvation results in the inhibition of DNA and RNA synthesis, …

Gasdermin D Permeabilization Of Mitochondrial Inner And Outer Membranes Accelerates And Enhances Pyroptosis, Rui Miao, Cong Jiang, Winston Y Chang, Haiwei Zhang, Jinsu An, Felicia Ho, Pengcheng Chen, Han Zhang, Caroline Junqueira, Dulguun Amgalan, Felix G Liang, Junbing Zhang, Charles L Evavold, Iva Hafner-Bratkovič, Zhibin Zhang, Pietro Fontana, Shiyu Xia, Markus Waldeck-Weiermair, Youdong Pan, Thomas Michel, Liron Bar-Peled, Hao Wu, Jonathan C Kagan, Richard N Kitsis, Peng Zhang, Xing Liu, Judy Lieberman

Faculty, Staff and Student Publications

Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial damage, but its underlying mechanism and functional consequences are largely unknown. Here, we show that the N-terminal pore-forming GSDMD fragment (GSDMD-NT) rapidly damaged both inner and outer mitochondrial membranes (OMMs) leading to reduced mitochondrial numbers, mitophagy, ROS, loss of transmembrane potential, attenuated oxidative phosphorylation (OXPHOS), and release of mitochondrial proteins and DNA from the matrix and intermembrane space. Mitochondrial damage occurred as soon as GSDMD was cleaved prior to plasma membrane damage. Mitochondrial damage was independent of the B-cell lymphoma 2 family and depended on GSDMD-NT binding to cardiolipin. Canonical and …

Oregon State Rank Assessment For Oregon Giant Earthworm (Driloleirus Macelfreshi), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Oregon giant earthworm (Driloleirus macelfreshi) using NatureServe methodology, 2023.

Pharyngeal Oxygen Delivery Device Sustains Manikin Lung Oxygenation Longer Than High-Flow Nasal Cannula, Jeramie B Hanson, John R Williams, Emily H Garmon, Phillip M Morris, Russell K Mcallister, Courtney N Shaver, William C Culp

Faculty, Staff and Student Publications

PURPOSE: Hypoxemia during a failed airway scenario is life threatening. A dual-lumen pharyngeal oxygen delivery device (PODD) was developed to fit inside a traditional oropharyngeal airway for undisrupted supraglottic oxygenation and gas analysis during laryngoscopy and intubation. We hypothesized that the PODD would provide oxygen as effectively as high-flow nasal cannula (HFNC) while using lower oxygen flow rates.

METHODS: We compared oxygen delivery of the PODD to HFNC in a preoxygenated, apneic manikin lung that approximated an adult functional residual capacity. Four arms were studied: HFNC at 20 and 60 liters per minute (LPM) oxygen, PODD at 10 LPM oxygen, …

Emergency Department Presentations Of Diabetic Ketoacidosis In A Large Cohort Of Children, Lisa E. Nigrovic, Nathan Kuppermann, Simona Ghetti, Jeff E. Schunk, Michael J. Stoner, Arleta Rewers, Julie K. Mcmanemy, Kimberly S. Quayle, Jennifer L. Trainor, Leah Tzimenatos, Jonathan E. Bennett, Maria Y. Kwok, Sage R. Myers, Kathleen M. Brown, T. Charles Casper, Cody S. Olsen, Nicole S. Glaser

Department of Emergency Medicine Faculty Papers

Background.

Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of childhood diabetes. However, the influence of demographic factors on presentation are not well-defined.

Methods.

We included children from 12 centers who were <18 years with DKA (glucose > 300 mg/dL, serum pH < 7.25, or serum bicarbonate <15 mEq/L) enrolled in the Pediatric Emergency Care Applied Research Network (PECARN) Fluid Therapies Under Investigation in DKA (FLUID) Trial. Data were also collected for children who presented to the centers during the enrollment period but were not enrolled due to disease or treatment-related reasons. We compared demographic, clinical, and biochemical findings among children with newly and previously diagnosed diabetes and children in different age groups.

Results.

Of the 1,679 DKA episodes in 1,553 children, 799 (47.5%) episodes occurred in children with newly diagnosed diabetes and 396 (23.6%) were severe (pH < 7.1). Newly diagnosed children <6 years of age were not more likely to have severe DKA in terms of pH, but had more severe hypocarbia and higher blood urea nitrogen levels, factors previously associated with the risk of cerebral injury. Lower socioeconomic status (SES) (based on family income and maternal education level) were associated with more severe DKA in new onset children, and recurrent DKA in the previously diagnosed children.

Conclusions.

Greater efforts are needed to identify the children with diabetes early and to prevent recurrent DKA, particularly among children in low-SES groups. Young children with DKA may need more intensive monitoring due to higher …

Targeted Suppression Of Mtorc2 Reduces Seizures Across Models Of Epilepsy, James Okoh, Jacqunae Mays, Alexandre Bacq, Juan A Oses-Prieto, Stefka Tyanova, Chien-Ju Chen, Khalel Imanbeyev, Marion Doladilhe, Hongyi Zhou, Paymaan Jafar-Nejad, Alma Burlingame, Jeffrey Noebels, Stephanie Baulac, Mauro Costa-Mattioli

Faculty, Staff and Students Publications

Epilepsy is a neurological disorder that poses a major threat to public health. Hyperactivation of mTOR complex 1 (mTORC1) is believed to lead to abnormal network rhythmicity associated with epilepsy, and its inhibition is proposed to provide some therapeutic benefit. However, mTOR complex 2 (mTORC2) is also activated in the epileptic brain, and little is known about its role in seizures. Here we discover that genetic deletion of mTORC2 from forebrain neurons is protective against kainic acid-induced behavioral and EEG seizures. Furthermore, inhibition of mTORC2 with a specific antisense oligonucleotide robustly suppresses seizures in several pharmacological and genetic mouse models …

Tlr7 Promotes Smoke-Induced Experimental Lung Damage Through The Activity Of Mast Cell Tryptase, Gang Liu, Tatt Jhong Haw, Malcolm R Starkey, Ashleigh M Philp, Stelios Pavlidis, Christina Nalkurthi, Prema M Nair, Henry M Gomez, Irwan Hanish, Alan Cy Hsu, Elinor Hortle, Sophie Pickles, Joselyn Rojas-Quintero, Raul San Jose Estepar, Jacqueline E Marshall, Richard Y Kim, Adam M Collison, Joerg Mattes, Sobia Idrees, Alen Faiz, Nicole G Hansbro, Ryutaro Fukui, Yusuke Murakami, Hong Sheng Cheng, Nguan Soon Tan, Sanjay H Chotirmall, Jay C Horvat, Paul S Foster, Brian Gg Oliver, Francesca Polverino, Antonio Ieni, Francesco Monaco, Gaetano Caramori, Sukhwinder S Sohal, Ken R Bracke, Peter A Wark, Ian M Adcock, Kensuke Miyake, Don D Sin, Philip M Hansbro

Faculty, Staff and Students Publications

Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded RNA viruses, and is increased in both human and cigarette smoke (CS)-induced, experimental chronic obstructive pulmonary disease (COPD). Here we show that the severity of CS-induced emphysema and COPD is reduced in TLR7-deficient mice, while inhalation of imiquimod, a TLR7-agonist, induces emphysema without CS exposure. This imiquimod-induced emphysema is reduced in mice deficient in mast cell protease-6, or when wild-type mice are treated with the mast cell stabilizer, cromolyn. Furthermore, therapeutic treatment with anti-TLR7 monoclonal antibody suppresses CS-induced emphysema, experimental COPD and accumulation of pulmonary mast cells in mice. …

Missense Mutations In Crx Homeodomain Cause Dominant Retinopathies Through Two Distinct Mechanisms, Yiqiao Zheng, Chi Sun, Xiaodong Zhang, Philip A Ruzycki, Shiming Chen

2020-Current year OA Pubs

Homeodomain transcription factors (HD TFs) are instrumental to vertebrate development. Mutations in HD TFs have been linked to human diseases, but their pathogenic mechanisms remain elusive. Here, we use

Mechanical Loading And Hyperosmolarity As A Daily Resetting Cue For Skeletal Circadian Clocks, Michal Dudek, Dharshika R J Pathiranage, Beatriz Bano-Otalora, Anna Paszek, Natalie Rogers, Cátia F Gonçalves, Craig Lawless, Dong Wang, Zhuojing Luo, Liu Yang, Farshid Guilak, Judith A Hoyland, Qing-Jun Meng

2020-Current year OA Pubs

Daily rhythms in mammalian behaviour and physiology are generated by a multi-oscillator circadian system entrained through environmental cues (e.g. light and feeding). The presence of tissue niche-dependent physiological time cues has been proposed, allowing tissues the ability of circadian phase adjustment based on local signals. However, to date, such stimuli have remained elusive. Here we show that daily patterns of mechanical loading and associated osmotic challenge within physiological ranges reset circadian clock phase and amplitude in cartilage and intervertebral disc tissues in vivo and in tissue explant cultures. Hyperosmolarity (but not hypo-osmolarity) resets clocks in young and ageing skeletal tissues …

A Case Study Examining Health And Fitness Effects Of Thru Hiking The Pacific Crest Trail, Holland Gaston, Dante Argento, Anna Grexton, Cory Greever

International Journal of Exercise Science: Conference Proceedings

The Pacific Crest Trail (PCT), a long-distance hiking route spanning from the U.S.-Mexico Border to the U.S.-Canada border, is a compelling research topic for studying human performance. Thru hiking involves enduring high volumes of moderate-vigorous exercise, load carriage of survival gear, environmental conditions, hydration, nutrition, sleep, and psychological well-being, alongside addressing challenges like navigation, limited resupply, encounters with wild animals and injury/illness. PURPOSE: This case study investigated the impact of thru hiking the PCT on physical fitness and health in a cohort of three non-elite male hikers. METHODS: The participants had two visits to the lab, following an 8-12 hour …

It’S Not Paradise For The Dogs And Shelter Workers: Dog Welfare And Occupational Stress In Animal Shelters In Hawaii, Lynn Morrison

People and Animals: The International Journal of Research and Practice

Dog welfare and occupational stress of animal shelter workers at two sites on Hawaii Island were examined. The east side had higher euthanasia rates than the west side. The two sites are in locales that differ culturally and economically. The goal of this study is to (1) elucidate how dog culture differs at the two sites and how those differences affect the health of dogs, and (2) assess the stress levels of shelter workers who must simultaneously care for the dogs while often having to euthanize them. Interviews and cortisol were obtained from the shelter workers and cortisol was obtained …

Finding 'New Oil' In The Silver State: A Cost Benefit Analysis Of Lithium Mining In Nevada, Alexandra Pelas

Governance: The Political Science Journal at UNLV

No abstract provided.

Scientific And Civic Cultural Literacy Level Of The Students Of The American University Of Madaba And Its Relationship To Personal Variables مستوى التنور الثقافي العلمي والمدني لدى طلبة الجامعة الامريكية في مادبا وعلاقتها ببعض المتغيرات الشخصية, Afag Sami Khzouz, Nayel Darweesh Al-Sharah

Jordanian Educational Journal

Abstract:

The purpose of this study was to investigate the level of scientific and civic cultural literacy of the American University of Madaba (AUM) students and its relationship to personal variables. The sample of the study consisted of 437 students registered for the first semester of the academic year 2019-2020 at AUM and sat for a scientific and civic test, the main research tool. The analysis of data collected showed that AUM students are culturally literate in the science field where the scores are at a high level. However, it was a little less in civics as it scored medium …

Using Encrypted Genotypes And Phenotypes For Collaborative Genomic Analyses To Maintain Data Confidentiality, Tianjing Zhao, Fangyi Wang, Richard Mott, Jack Dekkers, Hao Cheng

Department of Animal Science: Faculty Publications

To adhere to and capitalize on the benefits of the FAIR (findable, accessible, interoperable, and reusable) principles in agricultural genome- to-phenome studies, it is crucial to address privacy and intellectual property issues that prevent sharing and reuse of data in research and industry. Direct sharing of genotype and phenotype data is often prohibited due to intellectual property and privacy concerns. Thus, there is a pressing need for encryption methods that obscure confidential aspects of the data, without affecting the outcomes of certain statistical analyses. A homomorphic encryption method for genotypes and phenotypes (HEGP) has been proposed for single-marker regression in …

Design Thinking’S Effect On Empathy Development In Middle School English- Language Arts, Kim Starkey

Dissertations

The purpose of this quantitative study was to explore the impact of Design Thinking on students' empathy development in middle school English Language Arts (ELA) classrooms. The study involved two middle school instructors with eight classes, implementing Design Thinking, Reader's Workshop, and traditional ELA curriculum in different combinations (n =102) and two control classes (n =27).

The Adolescent Empathy Measure (AMES) and rubrics for analyzing student writing samples were used to assess changes in empathy. The AMES was given before and after the interventions, and the writing samples were analyzed before and after the interventions as well. The findings indicate …

The Utah Statesman, November 13, 2023, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Catfish Neurocranium, Fiona Smith, Juliana Ottens, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Crow's Nest, November 13, 2023, Crow's Nest Staff

Crow's Nest

The November 13, 2023, issue of the Crow's Nest.