Digital Commons Network^™

Covid-19 Health Crisis And Cross-Border Trade In West Africa, Tibi Didier Zoungrana, Olivier Combelem, Désiré Drabo

Journal of African Trade

The Economic Community of West African States (ECOWAS) Strict has adopted strict restrictions since the appearance of the new coronavirus disease in 2019 (Covid-19). This article seeks to assess the economic consequences of these measures on the activities of cross-border trade actors. To this end, data was collected from 144 traders, 8 customs services, 9 immigration services and 84 transporters using the quota method, distributed among 6 trade corridors (Ouagadougou-Téma, Dakar-Bamako, Ouagadougou-Abidjan, Lomé-Ouagadougou, Cotonou-Niamey and Lagos-Kano-Niamey). Empirical findings show that on all corridors, the health crisis has led to a decline in trade transactions and hence a decline in net …

Emerging Applications Of 3d Engineered Constructs From Plant Seed Extracts, Sedat Odabaş, Bora Gari̇pcan, Rihab Ksouri

Turkish Journal of Biology

Seeds, by-products derived from various plants such as mango, quince, and apples, are considered waste, though they have emerging commercial potential, and have been used in biological, industrial, and physiological research. Seed-derived natural macromolecules- mainly polysaccharides, mucilage, gums, and cellulose-have physicochemical and structural diversification, giving the potential for forming gels, texturing, thickening, and providing interfacial adsorption. Seed-derived natural macromolecules have been widely used during the last few years in cell research and tissue engineering applications. Their widespread approachability and safety, high rate of biodegradability, biocompatibility, supporting cell proliferation, and extracellular matrix synthesis are the main properties making plant seed derivatives …

Linc00460 Mediates Hmga2 Expression Through Binding To Mirna-143-5p Competitively In Gastric Carcinoma, Xuqing Zhu, Yanli Xiang, Feifei Mo, Lingling Jin

Turkish Journal of Biology

Background: Compelling evidence has manifested a strong association between aberrant expression of long noncoding RNAs (lncRNAs) and gastric carcinoma (GC) development. Nonetheless, biological impacts of differentially expressed lncRNAs (DElncRNAs) on GC are not scrutinized. Methods: Bioinformatics methods were employed for differential expression analysis and target gene prediction. MTT, colony formation, and Transwell methods were implemented for GC cell proliferation, migration, and invasion assessment. Western blot was implemented to test the protein level. The binding of genes was tested with dual-luciferase and RNA binding protein immunoprecipitation (RIP) approaches. Results: Noticeably high level of LINC00460 was observed in GC tissues and cells. …

Development And Validation Of A Scale For Measuring Pet Owners' Loyalty To Their Pet*, Seda Çavuş Alan, Abdullah Özen, Nurhan Hali̇sdemi̇r

Turkish Journal of Veterinary & Animal Sciences

Loyalty is a person's willingness to devote oneself to a cause and consists of concepts such as fidelity, not giving up, continuity, and stability. For this reason, this relationship stems from loyalty to be able to talk about a strong attachment between humans and animals. This study aimed to develop a measurement tool for the evaluation of the loyalty levels of people toward their pets. The qualitative method for determining the judgments in the scale will be called the pet loyalty scale; the quantitative methods (explanatory factor analysis and confirmatory factor analysis) were used to determine the validity and reliability …

Genotyping Of The Κ - Casein Gene By Pcr - Rflp (Acui Digestion) And Its Relationship To Milk Yield Traits In Anatolian Buffaloes, Murrah Buffaloes, And Their Crosses, Orhan Karadağ, Vasfi̇ye Kader Esen, Mehmet Aki̇f Yüksel, Mustafa Küçükkebabçi, Semi̇h Sevi̇m, İlkay Çeti̇n, Bi̇nnur Kaptan, Mehmet İhsan Soysal

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to investigate the polymorphism of the κ - casein gene (kappa casein, CSN3) in buffaloes and determine its effects on milk yield traits. Data were obtained from 2016 to 2019 from all animals in the ongoing Anatolian Buffalo Breeding Project. Genomic DNA was collected from a total of 209 buffaloes of different ages and sexes, namely 31 Murrah, 46 Anatolian buffaloes, and 132 of their crosses (Murrah × Anatolian). Genotyping of CSN3 gene by polymerase chain reaction-restriction fragment length polymorphism (PCR - RFLP) technique with restriction enzyme (AcuI) revealed three …

A Comparative Profile Of Certain Biochemical And Hematological Parameters In Angora And Akkeçi Goats During The Transition Period, Rabi̇a Aktaş, Erkan Pehli̇van

Turkish Journal of Veterinary & Animal Sciences

This study investigated the comparative changes in hematological and certain biochemical parameters such as glucose, cholesterol, triglyceride calcium, phosphorus and total protein during the transition period in Angora and Akkeçi goats aged 2-4 years. For this purpose, blood samples were regularly taken from the vena jugularis of each goat at 3, 2, and 1 weeks before kidding (-3, -2 and -1), on the day of parturition (0) and 1, 2, and 3 weeks after kidding (+1, +2 and +3). According to the statistical analysis results, the differences between the averages of the groups in terms of MCHC, MCH, Lym, THR, …

Serum Trace Element Levels In Dogs With Canine Visceral Leishmaniasis, Aycan Nuri̇ye Gazyağci, Bengü Bi̇lgi̇ç, Berna Baysal Bakay, Duygu Tarhan, Alev Meltem Ercan, Songül Erdoğan, Hasan Erdoğan, Mehmet Erman Or, Kerem Ural

Turkish Journal of Veterinary & Animal Sciences

Canine visceral leishmaniasis has been denoted as neglected despite being a very well-known disease. Trace element alteration has been recognized in humans with visceral and cutaneous leishmaniasis, together with canine visceral leishmaniasis. The trace elements occupy a vital position in the immunological system, and host immune responses mitigate defense against leishmaniasis. We aimed to select trace elements in a total of 45 dogs of several breeds; those at the age of 11 months to 6 and from both sexes (26 male and 19 female) were enrolled in the study. The dogs included in the study were divided into leishmaniasis-infected and …

Evaluation Of Leishmanicidal Activities Of 4-Thiazolidinones Against Leishmania Major, The Causative Agent Of Human Cutaneous Leishmaniasis, Kiera Bush

All Master's Theses

The leishmaniases are a group of vector-borne parasitic diseases that affect many developing countries including parts of Africa, India, and the Middle East in addition to Southern Europe and the Americas. It is estimated that worldwide, there are about 3 million new cases of leishmaniases each year leading to as many as 50,000 fatalities annually. The parasites that cause leishmaniasis belong to the genus Leishmania spp and are transmitted by the female phlebotomine sand fly. There are three clinical forms of the infection: visceral, mucocutaneous, and cutaneous. However, the focus of this paper is on cutaneous leishmaniasis that causes skin …

Does Apocynin Increase Liver Regeneration In The Partial Hepatectomy Model?, Yilmaz Bi̇lgi̇ç, Burhan Hakan Kanat, Onural Özhan, Azi̇be Yildiz, Zeynep Aksungur, Mehmet Erman Erdemli̇, Ni̇gar Vardi, Yusuf Türköz, Ahmet Sami̇ Akbulut, Adem Köse, Hakan Parlakpinar

Turkish Journal of Medical Sciences

Background/aim: Hepayocyte loss may develop secondary to liver surgery and at this point liver regeneration plays a significant act in terms of liver reserve. The purpose of this research was to investigate the efficacy of apocynin on liver regeneration and preservation after partial hepatectomy in rats. Materials and methods: A total of 32 rats, have been divided into 4 groups (n: 8) for hepatectomy model. Inflammatory and antiinflammatory parameters were measured from blood and liver tissue samples. In addition, the effects of apocynin were examined immunohistochemically and histopathologically from liver tissue. Results: In liver tissue samples, a significant difference has …

Investigation Of Igf-1, Igf-Bp3 And Igf-Bp5 Levels In Umbilical Cord Blood Of Infants With Developmental Dysplasia Of The Hip, Esra Demi̇rel, Eyüp Şenocak, Gamze Nur Ci̇mi̇lli̇ Şenocak, Ali̇ Şahi̇n, Berri̇n Göktuğ Kadioğlu, Özlem Gündüz

Turkish Journal of Medical Sciences

Background/aim: IGF-1 (insulin-like growth factor-1) is an important regulator of bone formation. Its deficiency has been associated with fetal growth disorders and hip dysplasia. The aim of this study was to evaluate whether IGF-1, IGF-BP3 (insulin like growth factorbinding protein 3), and IGF-BP5 levels in the umbilical cord blood can be predictive for early diagnosis of DDH. Materials and methods: Umbilical cord blood samples were collected from 860 mothers with pregnancies at high risk for DDH between October 2020 and January 2021. Mothers at 37-42 weeks of gestation, with risk factors for DDH, who delivered healthy infants were included. Blood …

The Role Of Superb Microvascular Imaging In Detecting Low-Grade Inflammation Among Adults And Those With Chronic Kidney Disease: A Preliminary Study, Alaaddi̇n Nayman, Nusret Seher, Mehmet Öztürk, Hali̇l Özer, Gülperi̇ Çeli̇k

Turkish Journal of Medical Sciences

Background/aim: Pathophysiologic changes associated with chronic inflammation occur with aging and more prominently in patients with chronic kidney disease (CKD), and an association between chronic inflammation and muscle wasting has been identified. The microcirculation is extremely sensitive to the inflammatory process and actively participates in it. In a healthy adult, angiogenesis is a strictly controlled and rare occurrence. However, aberrant angiogenesis and the development of new tiny blood vessels are known in chronic inflammatory diseases. Superb microvascular imaging (SMI) is a noninvasive technique that can evaluate tiny vessels with low blood flow and provide quantitative data. Our goal was to …

Behavioral Change Communication Tool Kit To Promote Hygiene Among School Children, Nousheen Akber Pradhan, Naseem Hashmani, Tazeen Saeed Ali, Rozina Karmaliani

Books

No abstract provided.

Solutions Still Searching For A Problem: A Call For Relevant Data To Support “Evergreening” Allegations, Erika Lietzan, Kristina Acri Née Lybecker

Fordham Intellectual Property, Media and Entertainment Law Journal

For years pharmaceutical policymaking discussions have been revolving around allegations of supposed “evergreening” by pharmaceutical companies, and policymakers have considered a range of significant policy reforms—including to antitrust law and drug regulatory law—to address this purported problem. This Article evaluates empirical data offered to substantiate “evergreening” and explains that these data—though mostly accurate—do not support proposed policy changes.

The “evergreening” claim is that by securing additional patents and FDA-related exclusivities after approval of their new drugs, brand drug companies enjoy a period of exclusivity in the market that is longer than the initial patent(s) and exclusivity on the drug would …

Silly Gene Patent Is Not My Lover: A Retrospective Analysis Of Myriad, Stephanie Huang

Fordham Intellectual Property, Media and Entertainment Law Journal

The U.S. Supreme Court’s decision in Association for Molecular Pathology v. Myriad Genetics, Inc. established that an isolated fragment of a gene—the basic unit of heredity—is not patent-eligible subject matter while simultaneously holding that complementary DNA (cDNA) of a gene is patent-eligible subject matter. The decision has been controversial and criticized for including two holdings that are internally inconsistent from both scientific and patent law perspectives. But are the short- and long-term criticisms overstated? A decade after Myriad, the various impacts of the case remain relevant, particularly to the biotechnology and genetic testing fields.

First, this Note examines whether Myriad …

2023-2024 Undergraduate Course Descriptions, Rochester Institute Of Technology

RIT Digital Archives

No abstract provided.

2023-2024 Undergraduate Bulletin, Rochester Institute Of Technology

RIT Digital Archives

No abstract provided.

2023-2024 Graduate Bulletin, Rochester Institute Of Technology

RIT Digital Archives

No abstract provided.

2023-2024 Graduate Course Descriptions, Rochester Institute Of Technology

RIT Digital Archives

No abstract provided.

Celebrating 70 Years, Case Western Reserve University School Of Law, Law-Medicine Center

Case Law-Med

• Message from the co-directors
• News flash
• Bringing in the experts
• Research roundup
• Faculty briefs
• Making health law history
• Uphill battle
• Above and beyond
• In the field
• Joining the team

Analysis Of Cryptic Variation Affecting Splicing In Early-Onset Mendelian Disease, Stephanie A. Felker

Dissertations

Genetic variants with poor annotation or unknown biological consequence are often systematically excluded in genomic analysis. Here I analyze variants near "poison exons” which are often absent from standard gene annotations and are alternative exons whose inclusion results in a premature termination codon. Neurodevelopmental disorders (NDDs) often result from rare genetic variation, but the genomic testing yield for NDDs remains around 50%, suggesting some clinically relevant rare variants may be missed by standard analyses. Variants that alter poison exons inclusion can lead to loss-of-function and may be highly penetrant contributors to disease. I analyzed variants found by genome sequencing in …

Novel Approaches To The Analysis Of Gene Regulation Data, Brian S. Roberts

Dissertations

The study of gene regulation is crucial to understanding differentiation, cell specialization, and response to external stimuli observed in multicellular organisms. Genome-scale technologies enabled by high-throughput sequencing have allowed insight into many aspects of gene regulation. However, these techniques produce large, complex data that require the development of computation-based analytical techniques. I present here two analytical techniques that I have created for gene regulation data. First, I describe an approach for the analysis of sequencing-based reporter data that reveals new features of human genetic sequence that generate biased strand transcription even out of genomic context. Next, I present a package …

Modeling Freely Flying Insects Using A Strongly Coupled High Fidelity Numerical Framework, Jeremy A. Pohly

Dissertations

Flying insects, with their remarkable abilities, serve as fascinating sources of inspiration. Deciphering the complex mechanisms that enable monarch butterflies to migrate nearly 80 million times their body length, requires advanced modeling tools. These tools must capture the interplay between non-linear wing aerodynamics, dynamic body responses, and flexible wings, characteristics of the monarch. A novel framework is introduced that tightly integrates these physical phenomena through a dynamic relaxation scheme. The model’s application extends to examining the longitudinal flight of monarch butterflies and the hovering flight of fruit flies, bumblebees, and hawkmoths. A bio-inspired feedback controller ensures stable flight across all …

Model-Free Control Methods For Gait And Standing Push Recovery In Bipedal Humanoid Robots, Jerry Sweafford Jr.

Dissertations

This dissertation examines the use of model-free control methods in various aspects of effective balance and gait control for two-legged humanoid robots. It explores what it should mean to improve balance and gait control for robots and proposes gait fragility as an alternative framework to the prevailing yet undefined dynamic stability objective. Next, it presents techniques for trajectory tracking control without deriving dynamic models, using modifications of the conventional reinforcement learning approach. Finally, it explores the use of deep online reinforcement learning with disturbance and assistance curricula for learning standing push recovery in bipeds.

International Whaling: Reframing The Iwc Moratorium For The Effective Conservation Of Whales, Kacey Hovden

Animal Law Review

The ocean once teemed with whales at seemingly every tide and crest, but due to centuries of overexploitation, whales are now a rare and coveted sight in many parts of the world. Today, the challenge of preventing these magnificent giants from extinction remains prevalent, with slow recovery rates and continued whaling practices in direct conflict. This Article examines the history of global whaling practices and the International Whaling Commission’s 1986 moratorium and argues for the establishment of an effective regulatory scheme permitting commercial whaling only on abundant whale stocks. The scheme would encourage whaling nations to remain members of the …

Book Review: Wildlife As Property Owners: A New Conception Of Animal Rights Written By Karen Bradshaw, Justin Starr

Natural Resources Journal

No abstract provided.

Development Of Sensors For Bacteria And Wound Environment Monitoring, Pannawich Thirabowonkitphithan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Diabetes mellitus (DM) is a leading cause of death and reduces life expectancy. Complications from diabetes have wreaked havoc not only on patients' quality of life, but also on the global burdens of public health and socioeconomic development. The most frequent complication among patients with diabetes mellitus is diabetic wounds, particularly diabetic foot ulcers because of the damage to sensory nerves and blood vessel issues brought on by elevated blood glucose levels. As a result, chronic wounds eventually develop and are prone to infection. In this study, several novel analytical devices for the detection of wound infections and the wound …

Mycobacterium Spp. Identification By Nanopore Technology, Samitanan Sunantawanit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Tuberculosis is caused by infection with Mycobacterium tuberculosis (MTB). Although TB and non-tuberculous mycobacteria (NTM) infection exhibit similar symptoms, their treatments differ significantly. NTM strains need a specific drug regimen and some NTM strains are resistant to anti-TB drugs. Hence, mycobacterial identification is crucial. At present, the culture-based technique is the gold standard in mycobacterium detection, but it is time-consuming (3-6 weeks). Here, this study aimed to develop mycobacterial amplicon-based nanopore sequencing (Myco-ANS) assay for the differentiation of eight reference strains of mycobacteria, as well as to assess the diagnostic accuracy of Myco-ANS compared with reference line probe assay for …

Gardenia Jasminoides Fruit Extract Alleviates Non-Steroidal Anti-Inflammatory Drug–Induced Gastropathy In Rats, Rinrada Worapongpaiboon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy is a health burden that requires effective treatment. Gardenia jasminoides fruit extract (GJE) protects the gastrointestinal tract by reducing inflammation with wide safety margins, but the underlying mechanisms are still indeterminate. Therefore, this thesis aimed to explore the effects of GJE pretreatment on NSAID-induced gastric injury in rats based on the hypothesis that GJE could attenuate the injury. Twenty-four male Sprague Dawley rats were assigned to 3 groups (n=8/group). The control group received a vehicle (7.5% NaHCO3). The NSAIDs group received indomethacin 200 mg/kg twice a day (4 hours apart) for 2 consecutive days. The …

Identification Of Active Region Of Colicin N Translocating Domain Involved In Its Antibacterial Activity, Wanassanan Lampromkaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

Colicins are bacteriocins produced by Escherichia coli (E. coli) and toxified themselves. In general, colicins comprise three domains, including the N-terminal domain or translocation (T) domain, the Receptor binding (R) domain, and the Cytotoxic (C) domain. The combination of these domains produces different types and activities of colicin. Colicin N is the smallest colicin and functioned in pore-formation by the C-domain on the E. coli membrane. The antimicrobial activity is regulated by the specific binding between OmpF and TolA (as receptor and translocator) at region OBS (OmpF binding site) and TABs (TolA binding site), respectively. They are then inserting the …

Identification And Functional Characterization Of Mads-Box Proteins And Ccos Involved In Carotenoid Metabolism In Durian Durio Zibethinus L. Pulps, Kittiya Tantisuwanichkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Durian (Durio zibethinus L.), known as the "King of fruits," holds significant economic importance in Thailand. Apart from its unique odor and sweet taste, durian pulp exhibits a yellow color, which is an important aspect of fruit quality. Carotenoids are essential compounds responsible for the yellow, orange, and red coloration in many fruits and vegetables. During durian fruit development and ripening processes, its pulp changes from white to yellow due to increased carotenoid accumulation. The carotenoid biosynthetic pathway, responsible for carotenoid production, is controlled by ethylene. However, the mechanism underlying this process in durian fruit is still unknow. Notably, the …