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2022

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Lessons Learned: Mike Leahy, Mercedes Cardona, Mike Leahy Dec 2022

Lessons Learned: Mike Leahy, Mercedes Cardona, Mike Leahy

Documents

Recommended Citation Sim Esmen, Yasemin (2022) "Lessons Learned: Mike Leahy," Journal of Financial Crises: Vol. 4 : Iss. 4, 622-625. Available at: https://elischolar.library.yale.edu/journal-of-financial-crises/vol4/iss4/32


Lessons Learned: Veerathai Santiprabhob, Mercedes Cardona, Veerathai Santiprabhob Dec 2022

Lessons Learned: Veerathai Santiprabhob, Mercedes Cardona, Veerathai Santiprabhob

Documents

Recommended Citation Haggerty, Maryann (2022) "Lessons Learned: Veerathai Santiprabhob," Journal of Financial Crises: Vol. 4 : Iss. 4, 637-639. Available at: https://elischolar.library.yale.edu/journal-of-financial-crises/vol4/iss4/36


Lessons Learned: Kevin Stiroh, Mercedes Cardona, Kevin Stiroh Dec 2022

Lessons Learned: Kevin Stiroh, Mercedes Cardona, Kevin Stiroh

Documents

Recommended Citation Cardona, Mercedes (2022) "Lessons Learned: Kevin Stiroh," Journal of Financial Crises: Vol. 4 : Iss. 4, 643-645. Available at: https://elischolar.library.yale.edu/journal-of-financial-crises/vol4/iss4/38


The 2008 Financial Crises On The Baltic Countries, Patrizia Baudino, Olga Lielkalne, Tomas Reichenbachas, Mari Tamm, Rastko Vrbaski Dec 2022

The 2008 Financial Crises On The Baltic Countries, Patrizia Baudino, Olga Lielkalne, Tomas Reichenbachas, Mari Tamm, Rastko Vrbaski

Documents

No abstract provided.


Bank Of Mongolia - About The Bank, Bank Of Mongolia (Mongolbank) Dec 2022

Bank Of Mongolia - About The Bank, Bank Of Mongolia (Mongolbank)

Documents

No abstract provided.


Lessons Learned: Andrew Gray, Mercedes Cardona, Andrew Gray Dec 2022

Lessons Learned: Andrew Gray, Mercedes Cardona, Andrew Gray

Documents

Recommended Citation: Cardona, Mercedes (2022) "Lessons Learned: Andrew Gray," Journal of Financial Crises: Vol. 4 : Iss. 4, 613-616. Available at: https://elischolar.library.yale.edu/journal-of-financial-crises/vol4/iss4/30


Lessons Learned: Deborah Perelmuter, Mercedes Cardona, Deborah Perelmuter Dec 2022

Lessons Learned: Deborah Perelmuter, Mercedes Cardona, Deborah Perelmuter

Documents

Recommended Citation Cardona, Mercedes (2022) "Lessons Learned: Deborah Perelmuter," Journal of Financial Crises: Vol. 4 : Iss. 4, 630-632. Available at: https://elischolar.library.yale.edu/journal-of-financial-crises/vol4/iss4/34


Lessons Learned: Erik Sirri, Mercedes Cardona, Erik Sirri Dec 2022

Lessons Learned: Erik Sirri, Mercedes Cardona, Erik Sirri

Documents

Recommended Citation Cardona, Mercedes (2022) "Lessons Learned: Erik Sirri," Journal of Financial Crises: Vol. 4 : Iss. 4, 640-642. Available at: https://elischolar.library.yale.edu/journal-of-financial-crises/vol4/iss4/37


Lessons Learned: Patrick Honohan, Mercedes Cardona, Patrick Honohan Dec 2022

Lessons Learned: Patrick Honohan, Mercedes Cardona, Patrick Honohan

Documents

Recommended Citation Haggerty, Maryann (2022) "Lessons Learned: Patrick Honohan," Journal of Financial Crises: Vol. 4 : Iss. 4, 617-621. Available at: https://elischolar.library.yale.edu/journal-of-financial-crises/vol4/iss4/31


A Quantitative Examination Of The Influence Of Social And Structural Communication Variables On The Social Connectedness Of People Experiencing Homelessness, Shawn Michael Evans Dec 2022

A Quantitative Examination Of The Influence Of Social And Structural Communication Variables On The Social Connectedness Of People Experiencing Homelessness, Shawn Michael Evans

Graduate Theses and Dissertations

This thesis examined the influence of social and structural communication variables on the perceived social connectedness of people experiencing homelessness in the Northwest Arkansas (NWA) and Joplin, Missouri areas. This study employed the ecological perspective of communication infrastructure theory (CIT; Ball-Rokeach et al., 2001) and a communication perspective which envisions communicative interaction as constitutive of social experience. Using survey data from 166 participants, this study examined 11 research questions and hypotheses drawn from extant literature on homelessness, social connectedness, and CIT. ANOVAs, t-tests, and hierarchical multiple regression analyses revealed a complex relationship between individuals and the communicative environment. This study …


Loss-Absorbing Capacity Requirements In Resolution For G-Sibs In The Eu And The Us: A Cross-Jurisdictional Comparison, Riad Benahmed Dec 2022

Loss-Absorbing Capacity Requirements In Resolution For G-Sibs In The Eu And The Us: A Cross-Jurisdictional Comparison, Riad Benahmed

Documents

No abstract provided.


Suicide At The Intersection Of Race And Gender, Marina Geider Dec 2022

Suicide At The Intersection Of Race And Gender, Marina Geider

Masters Theses

Sociological studies have examined suicide rate differences between groups since the work of Durkheim in 1897, and current literature still draws on his classic theories and methods. Although research has begun identifying the social factors that affect the suicides of Black and White populations differentially, little progress has been made towards an understanding of Black female suicide. The present study takes an intersectional approach to Durkheim's social integration-regulation thesis to bridge this gap. Several negative binomial regression analyses were employed to model suicide counts for Black men, Black women, non-Hispanic White men, and non-Hispanic White women in the United States. …


Implementation Of The Plan For Every Part (Pfep) Tool And Additional Methodologies For Operational Improvement., Bernardo Luis Borges Pedroso Dec 2022

Implementation Of The Plan For Every Part (Pfep) Tool And Additional Methodologies For Operational Improvement., Bernardo Luis Borges Pedroso

Masters Theses

The work focused on the inventory management of Dimplex Thermal Solutions, which had a profoundly overstocked warehouse and was suffering from significant operating expenses, due to the absence of a grounded ordering policy and the need to rent external storage space, respectively.

The main objective of the thesis was to solve the primarily mentioned problems, by constructing a Plan For Every Part (PFEP) tool, followed by the application of an inventory policy and the proposal of a redesigned warehouse layout, to compute ideal stock values and calculate the footprint requirements for Dimplex’s updated inventory levels, respectively. The execution step concerned …


Stability Of Universal Screening Over Time: An Examination Of The Student Risk Screening Scale, Rebecca Wagner Lovelace Dec 2022

Stability Of Universal Screening Over Time: An Examination Of The Student Risk Screening Scale, Rebecca Wagner Lovelace

Master's Theses

Universal screening is a proactive method to identify students that are at risk for social-emotional and behavior (SEB) problems and provide information to schools to support early intervention for at risk children. Current recommendations for practice indicate screening should be conducted at three time points during the school year. Previous studies suggest that this recommendation is not empirically based and fewer screenings per year may be sufficient for identifying students at risk. The current study seeks to extend the literature regarding the stability and consistency of screening scores over time by analyzing ratings from the Student Risk Screening Scale (SRSS) …


Drinking Motives As Mediators For The Relationships Between Overparenting And Alcohol Outcomes, Tatum Freeman Dec 2022

Drinking Motives As Mediators For The Relationships Between Overparenting And Alcohol Outcomes, Tatum Freeman

Master's Theses

The present study investigated the mediating role of drinking motives in the relationship between overparenting and alcohol outcomes using a sample of 207 traditional age college students (i.e., 18-25 years old; M = 19.8, SD = 1.64). Data on participant demographics, drinking motives, the practices of participants’ primary caregiver, typical weekly drinking, hazardous drinking, and alcohol consequences were collected via SONA (an online participant management software that allows researchers to collect data from a university psychology subject pool). Participants were 89.4% female and 54.1% White. Coping and conformity drinking motives partially mediated the relationships between overparenting, alcohol consequences, and hazardous …


Crisis Communication In The Ukraine-Russia Conflict: Use Of Facebook By Un Humanitarian Organizations, Rubaiya Zannat Dec 2022

Crisis Communication In The Ukraine-Russia Conflict: Use Of Facebook By Un Humanitarian Organizations, Rubaiya Zannat

Master's Theses

The proliferation of social media has made it incredibly simple to quickly disseminate valuable information to a large audience. Thus, numerous organizations are now heavily leveraging these social networking platforms as a means for managing their crisis responses. Through a content analysis of 355 posts concerning the Ukraine-Russia conflict made by five large UN humanitarian organizations between February and May, 2022, on their official Facebook pages, this study investigated organizational crisis communication patterns. Findings suggest that UN humanitarian organizations extensively used "threat" and "need for change" as crisis characteristics to delineate the Ukraine-Russia situation, whereas “protection of safety and security,” …


Plant Productivity And Diversity In Coastal Wetlands In Mississippi – Impact Of Hydrological Extremes, Kodi Feldpausch Dec 2022

Plant Productivity And Diversity In Coastal Wetlands In Mississippi – Impact Of Hydrological Extremes, Kodi Feldpausch

Master's Theses

Wetlands are highly productive ecosystems that provide important ecosystem services and are threatened by extreme hydrological events. I evaluated how diversion of freshwater like Bonnet Carré Spillway openings in Louisiana, US, affected vegetation productivity and diversity in salt marshes on the neighboring Mississippi Gulf Coast, US. My study area is two estuarine systems that differ in their proximity to the Bonnet Carré Spillway, elevation, and salinity including Hancock County Marshes on the west, and Grand Bay National Estuarine Research Reserve (NERR) on the east in Mississippi. I collected above- and belowground biomass samples in 2020 and 2021, developed linear mixed-effects …


Cdc’S Covid-19 Vaccination Messages And Public Engagement: A Study On Facebook Posts, Hasan Mahmud Faisal Dec 2022

Cdc’S Covid-19 Vaccination Messages And Public Engagement: A Study On Facebook Posts, Hasan Mahmud Faisal

Master's Theses

Government health agencies utilize social media for public health interventions. This study examines how CDC, the national public health agency of the United States, use Facebook to disseminate COVID-19 vaccine messages and to get public engagement towards them over the past two years (2020-2022). Investigating the process of dialogic potentials of Facebook from the dialogic theory of public relations perspective, the current study analyzes 681 posts and 3,405 comments from CDC’s official Facebook page. Thematic analysis of posts yields three dominant themes such as “Vaccine supportive”, “availability of vaccine”, and “up to date information”. Comment analysis shows positive sentiment to …


Seeking Of Agriculture Information Through Mobile Phones By Rice Farmers In Ogoja Agricultural Zone, Cross River State, Nigeria, Friday O. Idiku, Ginini Francis Elemi, Ejeje Igwe Agube, Comfort Aya, Anthonia Egem Okem Dec 2022

Seeking Of Agriculture Information Through Mobile Phones By Rice Farmers In Ogoja Agricultural Zone, Cross River State, Nigeria, Friday O. Idiku, Ginini Francis Elemi, Ejeje Igwe Agube, Comfort Aya, Anthonia Egem Okem

Library Philosophy and Practice (e-journal)

Seeking agriculture information is common among rice farmers in many parts of the world. The study was aimed at assessing the Seeking of Agriculture Information through Mobile Phone by Rice Farmers in Ogoja Agricultural Zone of Cross River State Nigeria The specific objectives of the study were to; identify the socio-economic characteristics of the farmers, determine factors influencing the seeking of agriculture information through mobile phones by rice farmers, and to examine the constraints to use of mobile phones by rice farmers in Ogoja Agricultural Zone of Cross River State Nigeria. A multistage sampling technique was adopted to select ninety …


Feasibility Of Tracking Human Kinematics With Simultaneous Localization And Mapping (Slam), Sepehr Laal, Paul Vasilyev, Sean Pearson, Mateo Aboy, James Mcnames Dec 2022

Feasibility Of Tracking Human Kinematics With Simultaneous Localization And Mapping (Slam), Sepehr Laal, Paul Vasilyev, Sean Pearson, Mateo Aboy, James Mcnames

Electrical and Computer Engineering Faculty Publications and Presentations

We evaluated a new wearable technology that fuses inertial sensors and cameras for tracking human kinematics. These devices use on-board simultaneous localization and mapping (SLAM) algorithms to localize the camera within the environment. Significance of this technology is in its potential to overcome many of the limitations of the other dominant technologies. Our results demonstrate this system often attains an estimated orientation error of less than 1o and a position error of less than 4 cm as compared to a robotic arm. This demonstrates that SLAM’s accuracy is adequate for many practical applications for tracking human kinematics.


Axillary Artery Fibromuscular Dysplasia In A Symptomatic Type B Aortic Dissection Causing Acute Limb Ischemia, Brian Sullivan, Nathan Droz, Vipul Khetarpaul Dec 2022

Axillary Artery Fibromuscular Dysplasia In A Symptomatic Type B Aortic Dissection Causing Acute Limb Ischemia, Brian Sullivan, Nathan Droz, Vipul Khetarpaul

2020-Current year OA Pubs

Fibromuscular dysplasia (FMD) can manifest outside of its classic presentation with unusual pathology. In the present report, we have described a case of an older male patient with aortic degeneration related to acute type B dissection who had required emergent left carotid-subclavian transposition and aortic stenting. Intraoperatively, his axillary artery FMD led to acute upper extremity ischemia. The patient was treated with classic maneuvers, including balloon angioplasty, reflecting the best practices in vascular surgery. We have also discussed the diagnosis, classification, and management of FMD.


Outcomes In Participants With Failure Of Initial Antibacterial Therapy For Hospital-Acquired/Ventilator-Associated Bacterial Pneumonia Prior To Enrollment In The Randomized, Controlled Phase 3 Aspect-Np Trial Of Ceftolozane/Tazobactam Versus Meropenem, Marin H Kollef, Jean-François Timsit, Ignacio Martin-Loeches, Richard G Wunderink, Jennifer A Huntington, Erin H Jensen, Brian Yu, Christopher J Bruno Dec 2022

Outcomes In Participants With Failure Of Initial Antibacterial Therapy For Hospital-Acquired/Ventilator-Associated Bacterial Pneumonia Prior To Enrollment In The Randomized, Controlled Phase 3 Aspect-Np Trial Of Ceftolozane/Tazobactam Versus Meropenem, Marin H Kollef, Jean-François Timsit, Ignacio Martin-Loeches, Richard G Wunderink, Jennifer A Huntington, Erin H Jensen, Brian Yu, Christopher J Bruno

2020-Current year OA Pubs

BACKGROUND: Ceftolozane/tazobactam, a combination antibacterial agent comprising an anti-pseudomonal cephalosporin and β-lactamase inhibitor, is approved for the treatment of hospital-acquired/ventilator-associated bacterial pneumonia (HABP/VABP) in adults. Participants in the ASPECT-NP trial received ceftolozane/tazobactam (3 g [2 g ceftolozane/1 g tazobactam] every 8 h) or meropenem (1 g every 8 h). Participants failing prior antibacterial therapy for the current HABP/VABP episode at study entry had lower 28-day all-cause mortality (ACM) rates with ceftolozane/tazobactam versus meropenem treatment. Here, we report a post hoc analysis examining this result.

METHODS: The phase 3, randomized, controlled, double-blind, multicenter, noninferiority trial compared ceftolozane/tazobactam versus meropenem for treatment …


Dietary And Complementary Feeding Practices Of Us Infants, 6 To 12 Months: A Narrative Review Of The Federal Nutrition Monitoring Data, Regan L Bailey, Jaime S Stang, Teresa A Davis, Timothy S Naimi, Barbara O Schneeman, Kathryn G Dewey, Sharon M Donovan, Rachel Novotny, Ronald E Kleinman, Elsie M Taveras, Lydia Bazzano, Linda G Snetselaar, Janet De Jesus, Kellie O Casavale, Eve E Stoody, Joseph D Goldman, Alanna J Moshfegh, Donna G Rhodes, Kirsten A Herrick, Kristin Koegel, Cria G Perrine, Tusarebecca Pannucci Dec 2022

Dietary And Complementary Feeding Practices Of Us Infants, 6 To 12 Months: A Narrative Review Of The Federal Nutrition Monitoring Data, Regan L Bailey, Jaime S Stang, Teresa A Davis, Timothy S Naimi, Barbara O Schneeman, Kathryn G Dewey, Sharon M Donovan, Rachel Novotny, Ronald E Kleinman, Elsie M Taveras, Lydia Bazzano, Linda G Snetselaar, Janet De Jesus, Kellie O Casavale, Eve E Stoody, Joseph D Goldman, Alanna J Moshfegh, Donna G Rhodes, Kirsten A Herrick, Kristin Koegel, Cria G Perrine, Tusarebecca Pannucci

Children’s Nutrition Research Center Staff Publications

Complementary foods and beverages (CFBs) are key components of an infant’s diet in the second 6 months of life. This article summarizes nutrition and feeding practices examined by the 2020 Dietary Guidelines Advisory Committees during the CFB life stage. Breastfeeding initiation is high (84%), but exclusive breastfeeding at 6 months (26%) is below the Healthy People 2030 goal (42%). Most infants (51%) are introduced to CFBs sometime before 6 months. The primary mode of feeding (ie, human milk fed [HMF]; infant formula or mixed formula and human milk fed [FMF]) at the initiation of CFBs is associated with the timing …


Esg Framework For Investment Managers Of Wuimc, Morgan Davies, Sammi Fremont, Sophie Kielian, Lauren Michaels, Abree Peterson, Eve Spalding, Jane Whellan Dec 2022

Esg Framework For Investment Managers Of Wuimc, Morgan Davies, Sammi Fremont, Sophie Kielian, Lauren Michaels, Abree Peterson, Eve Spalding, Jane Whellan

Sustainability Exchange Projects

ESG Framework for Investment Managers for Sustainability Exchange, Washington University in St. Louis, Fall 2022


St. Louis Regional Greenhouse Gas Reduction Strategy, Jennifer Kuriloff, Alex Marchok, Megan Ross, Qifeng Tian, Mahek Prakash Vora, Angela Yokley Dec 2022

St. Louis Regional Greenhouse Gas Reduction Strategy, Jennifer Kuriloff, Alex Marchok, Megan Ross, Qifeng Tian, Mahek Prakash Vora, Angela Yokley

Sustainability Exchange Projects

This semester the Greenhouse Gas Reduction Team (GHGRT) of the Sustainability Exchange program at Washington University in St. Louis was tasked with initial planning to decrease greenhouse gas emissions in the St. Louis area for OneSTL. To do so, GHGRT began by meeting with experts in the field, including Rene Dulle, Tim Michels, and Emily Andrews, to determine the best course of action and get insight into the situation as it stands. Based on this information, we decided to focus on building energy use and resulting carbon emissions. The team then researched energy use in the city of St. Louis …


International Pooled Patient-Level Meta-Analysis Of Ketamine Infusion For Depression: In Search Of Clinical Moderators, Rebecca B Price, Nicholas Kissel, Andrew Baumeister, Rebecca Rohac, Mary L Woody, Elizabeth D Ballard, Carlos A Zarate, William Deakin, Chadi G Abdallah, Adriana Feder, Dennis S Charney, Michael F Grunebaum, J John Mann, Sanjay J Mathew, Bronagh Gallagher, Declan M Mcloughlin, James W Murrough, Suresh Muthukumaraswamy, Rebecca Mcmillan, Rachael Sumner, George Papakostas, Maurizio Fava, Rebecca Hock, Jennifer L Phillips, Pierre Blier, Paulo Shiroma, Peter Šóš, Tung-Ping Su, Mu-Hong Chen, Mikael Tiger, Johan Lundberg, Samuel T Wilkinson, Meredith L Wallace Dec 2022

International Pooled Patient-Level Meta-Analysis Of Ketamine Infusion For Depression: In Search Of Clinical Moderators, Rebecca B Price, Nicholas Kissel, Andrew Baumeister, Rebecca Rohac, Mary L Woody, Elizabeth D Ballard, Carlos A Zarate, William Deakin, Chadi G Abdallah, Adriana Feder, Dennis S Charney, Michael F Grunebaum, J John Mann, Sanjay J Mathew, Bronagh Gallagher, Declan M Mcloughlin, James W Murrough, Suresh Muthukumaraswamy, Rebecca Mcmillan, Rachael Sumner, George Papakostas, Maurizio Fava, Rebecca Hock, Jennifer L Phillips, Pierre Blier, Paulo Shiroma, Peter Šóš, Tung-Ping Su, Mu-Hong Chen, Mikael Tiger, Johan Lundberg, Samuel T Wilkinson, Meredith L Wallace

Children’s Nutrition Research Center Staff Publications

Depression is disabling and highly prevalent. Intravenous (IV) ketamine displays rapid-onset antidepressant properties, but little is known regarding which patients are most likely to benefit, limiting personalized prescriptions. We identified randomized controlled trials of IV ketamine that recruited individuals with a relevant psychiatric diagnosis (e.g., unipolar or bipolar depression; post-traumatic stress disorder), included one or more control arms, did not provide any other study-administered treatment in conjunction with ketamine (although clinically prescribed concurrent treatments were allowable), and assessed outcome using either the Montgomery-Åsberg Depression Rating Scale or the Hamilton Rating Scale for Depression (HRSD-17). Individual patient-level data for at least …


Mild Hypoxic-Ischemic Encephalopathy (Hie): Timing And Pattern Of Mri Brain Injury, Yi Li, Jessica L Wisnowski, Lina Chalak, Amit M Mathur, Robert C Mckinstry, Genesis Licona, Dennis E Mayock, Taeun Chang, Krisa P Van Meurs, Tai-Wei Wu, Kaashif A Ahmad, Marie-Coralie Cornet, Rakesh Rao, Aaron Scheffler, Yvonne W Wu Dec 2022

Mild Hypoxic-Ischemic Encephalopathy (Hie): Timing And Pattern Of Mri Brain Injury, Yi Li, Jessica L Wisnowski, Lina Chalak, Amit M Mathur, Robert C Mckinstry, Genesis Licona, Dennis E Mayock, Taeun Chang, Krisa P Van Meurs, Tai-Wei Wu, Kaashif A Ahmad, Marie-Coralie Cornet, Rakesh Rao, Aaron Scheffler, Yvonne W Wu

2020-Current year OA Pubs

BACKGROUND: Mild hypoxic-ischemic encephalopathy (HIE) is increasingly recognized as a risk factor for neonatal brain injury. We examined the timing and pattern of brain injury in mild HIE.

METHODS: This retrospective cohort study includes infants with mild HIE treated at 9 hospitals. Neonatal brain MRIs were scored by 2 reviewers using a validated classification system, with discrepancies resolved by consensus. Severity and timing of MRI brain injury (i.e., acute, subacute, chronic) was scored on the subset of MRIs that were performed at or before 8 days of age.

RESULTS: Of 142 infants with mild HIE, 87 (61%) had injury on …


Ten Simple Rules And A Template For Creating Workflows-As-Applications, Michael J. Roach, N. Tessa Pierce-Ward, Radoslaw Suchecki, Vijini Mallawaarachchi, Bhavya Papudeshi, Scott A. Handley, C. Titus Brown, Nathan S. Watson-Haigh, Robert A. Edwards Dec 2022

Ten Simple Rules And A Template For Creating Workflows-As-Applications, Michael J. Roach, N. Tessa Pierce-Ward, Radoslaw Suchecki, Vijini Mallawaarachchi, Bhavya Papudeshi, Scott A. Handley, C. Titus Brown, Nathan S. Watson-Haigh, Robert A. Edwards

2020-Current year OA Pubs

No abstract provided.


Transferability Of Alzheimer Disease Polygenic Risk Score Across Populations And Its Association With Alzheimer Disease-Related Phenotypes, Sang-Hyuk Jung, Carlos Cruchaga, Et Al. Dec 2022

Transferability Of Alzheimer Disease Polygenic Risk Score Across Populations And Its Association With Alzheimer Disease-Related Phenotypes, Sang-Hyuk Jung, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Polygenic risk scores (PRSs), which aggregate the genetic effects of single-nucleotide variants identified in genome-wide association studies (GWASs), can help distinguish individuals at a high genetic risk for Alzheimer disease (AD). However, genetic studies have predominantly focused on populations of European ancestry.

OBJECTIVE: To evaluate the transferability of a PRS for AD in the Korean population using summary statistics from a prior GWAS of European populations.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study developed a PRS based on the summary statistics of a large-scale GWAS of a European population (the International Genomics of Alzheimer Project; 21 982 AD cases …


Cisplatin Exposure Acutely Disrupts Mitochondrial Bioenergetics In The Zebrafish Lateral-Line Organ, David S Lee, Angela Schrader, Mark Warchol, Lavinia Sheets Dec 2022

Cisplatin Exposure Acutely Disrupts Mitochondrial Bioenergetics In The Zebrafish Lateral-Line Organ, David S Lee, Angela Schrader, Mark Warchol, Lavinia Sheets

2020-Current year OA Pubs

Cisplatin is a commonly used chemotherapeutic agent that causes debilitating high-frequency hearing loss. No targeted therapies currently exist to treat cisplatin ototoxicity, partly because the underlying mechanisms of cisplatin-induced hair cell damage are not completely defined. Zebrafish may offer key insights to cisplatin ototoxicity because their lateral-line organ contains hair cells that are remarkably similar to those within the cochlea but are optically accessible, permitting observation of cisplatin injury in live intact hair cells. In this study, we used a combination of genetically encoded biosensors in zebrafish larvae and fluorescent indicators to characterize changes in mitochondrial bioenergetics in response to …