Digital Commons Network^™

Biomarker, Treatment, And Socio-Demographic Factors Affecting Opioid Use Disorder Treatment Retention, Fernand A. De Los Reyes

Dissertations

Increasing mortality from opioid overdose and low treatment engagement are significant public health concerns. Along with increasing health care and criminal justice enforcement costs, there is an urgent need to study the factors associated with treatment retention in opioid use disorder. The study investigated the relative impact of the biomarker cholesterol on treatment retention in an opioid treatment program (OTP) clinic. Further, it examined the medical comorbidities, treatment, and socio-demographic variables that impact opioid use disorder treatment retention. This study was a secondary analysis of patient health records (n=267) in an opioid treatment program clinic. The study employed a hierarchical …

Factors Associated With New Hospital Nurses' Self-Efficacy In Providing Palliative End-Of-Life Care, Penny Marie Briese

Dissertations

Self-efficacy is defined as confidence in one's competence; the ability to successfully accomplish tasks and achieve favorable outcomes (Bandura, 1997). Many nurses today say they feel their undergraduate education was inadequate for them to feel competent to provide palliative and EOL patient care. (Chiplaskey, 2016; Scherlin & Quinn, 2016; Zheng et al., 2018).). Inadequate EOL preparation also results in nurses experiencing distress, death anxiety, burnout, feeling overwhelmed and leaving practice within just a few years (Friedman et al., 2011; Gaw, 2012; Kovner et al., 2006; Parry, 2008; Silverstein, 2017, November 28; Suzuki et al., 2008; Wilson & Kirshbaum, 2013). This …

Needs Assessment And Mentor Program Development For Sinclair School Of Nursing, Mindy Thompson

DNP and Student Works

An estimated 1.13 million new registered nurses are needed to fill new jobs and replace retiring nurses from 2012-2022. However, the nurse faculty shortage is a primary barrier to expanding the nursing workforce over the next decade. Nurses moving from the clinical setting to the academic setting need preparation, professional growth, and the development of a social network to make the transition a lasting one. Not only do mentoring relationships improve the work environment, but there is also an indication that it improves organizational commitment by achieving a sense of accomplishment, autonomy in their role, support for professional growth, and …

The Contribution Of Non-Tropical Cyclone Vortices To The Rainfall Of The Philippines, Lyndon Mark P. Olaguera, Jun Matsumoto, John A. Manalo

Physics Faculty Publications

Weaker disturbances than tropical cyclones (TCs) such as tropical depressions and cold surges can significantly induce heavy rainfall and flooding events over the Philippines. However, the analysis of these disturbances including their rainfall contributions are often neglected in previous studies. As the first attempt to address this research gap, this study investigates the rainfall contribution of non-TC vortices over the Philippines from 1979 to 2020. Only those rainfall-producing non-TC vortices that formed and appeared within a 500-km radius from the Philippine coastline were examined in this study. A total of 7,686 non-TC vortex days (50% of the total days during …

Human Papillomavirus Vaccine Administration Trends Among Commercially Insured Us Adults Aged 27-45 Years Before And After Advisory Committee On Immunization Practices Recommendation Change, 2007-2020, Ryan Suk, Kaiping Liao, Cici X Bauer, Catherine Basil, Meng Li

Faculty, Staff and Student Publications

IMPORTANCE: In 2019, the Advisory Committee on Immunization Practices (ACIP) recommended patient-clinician shared decision-making for human papillomavirus (HPV) vaccination in adults aged 27 to 45 years. Less is known about the HPV vaccine administration trends in this age group before and after this recommendation update.

OBJECTIVE: to examine the association between the ACIP recommendation update and the HPV vaccine administration among US adults aged 27 to 45 years.

DESIGN, SETTING, AND PARTICIPANTS: This large commercial claim-based retrospective cohort study used the Optum Clinformatics database for validated claims from January 1, 2007, through December 31, 2020. A total of 22 600 …

Improving Adjacency List Storage Methods For Polypeptide Similarity Analysis, Arianna Swensen

Honors Theses

Protein design is a complex biomolecular and computational problem. Working on increasingly large protein folding problems requires an improvement in current analysis methods available. This work first discusses various methods of protein design, including de novo protein design, which is the primary focus of this thesis. Then, a new approach utilizing a B+ tree to effectively store and query a graph of keys and vertices is proposed in order to store the number of times two polypeptides are considered to be similar. This approach is found to have a reduction in time complexity from current mapping methods and thus provides …

Ensemble Concerts: Isu String Project Winter Concert, December 2, 2022, Benjamin De Kock, Aaron Jacobs, Cora Swenson Lee, Katherine Lewis

School of Music Programs

Center for the Performing Arts
December 2, 2022
Friday Evening
7:00 p.m.

Sga 54 Senate 2022-12-02 Agenda, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Sustained Aurora Kinase B Expression Confers Resistance To Pi3k Inhibition In Head And Neck Squamous Cell Carcinoma, Pooja A Shah, Vaishnavi Sambandam, Anne M Fernandez, Hongyun Zhao, Tuhina Mazumdar, Li Shen, Qi Wang, Kazi M Ahmed, Soma Ghosh, Mitchell J Frederick, Jing Wang, Faye M Johnson

Faculty, Staff and Student Publications

UNLABELLED: Tumor suppressor mutations in head and neck squamous cell carcinoma (HNSCC) dominate the genomic landscape, hindering the development of effective targeted therapies. Truncating and missense mutations in NOTCH1 are frequent in HNSCC, and inhibition of PI3K can selectively target NOTCH1 mutant (NOTCH1MUT) HNSCC cells. In this study, we identify several proteins that are differentially regulated in HNSCC cells after PI3K inhibition based on NOTCH1MUT status. Expression of Aurora kinase B (Aurora B), AKT, and PDK1 following PI3K inhibition was significantly lower in NOTCH1MUT cell lines than in wild-type NOTCH1 (NOTCH1WT) cells or NOTCH1MUT cells with acquired resistance to PI3K …

Medical Monitoring Working Group Meeting Minutes, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2022 Draft Final Blacktail Creek Groundwater Hydraulic Control System Remedial Design Work Plan, Stantec Consulting Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2022 Draft Final Blacktail Creek Groundwater Hydraulic Control System Remedial Design Work Plan, Stantec Consulting Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

African American Family Members’ Needs And Experiences During A Loved One’S End-Of-Life, Kelley Obringer

Theses and Dissertations

This study aimed to explore African American family members’ needs and experiences during their loved one’s end-of-life. In Chapter 1, a literature review was conducted to review the current state of the literature regarding African American family members’ needs and experiences during their loved one’s end-of-life. Chapter 2 includes a qualitative exploratory study of African American family members’ needs and experiences during their loved one’s end-of-life. The study sample consisted of family members of African Americans being cared for through services provided by an outpatient palliative care facility in the Southeastern United States. Family members answered five open-ended interview questions …

2022-12-02 Minutes Of The Executive Committee Of The Academic Senate, University Of Dayton. Academic Senate. Executive Committee

ECAS Minutes

Approved minutes of a meeting of the Executive Committee of the Academic Senate of the University of Dayton.

The Future Of Our Economy ‐ Part Ii, Ishrat Husain Dr.

Faculty Research - Newspaper and Magazine Articles

The short-term measures described in Part I will not have the desired effects unless the emphasis is shifted in our school system towards Science, Technology, Engineering, Creative Arts and Mathematics (STEAM) subjects. Focus on these subjects along with content, hardware, network, software application, choices of pedagogical tools and so on all has to be entrusted to private service providers (PSP) under performance-linked contractual agreements. The setting up of computer labs, local area networks, data centres etc would require a massive jump in the allocation of budgetary resources towards education. But this would be a worthwhile use of our scarce resources …

A Time And Place For Inhibiting Autophagy, Boyi Gan

Faculty, Staff and Student Publications

Autophagy is an attractive therapeutic target in cancer. Successful autophagy-focused clinical intervention will require a detailed understanding of when and where autophagy is important during tumorigenesis. In this issue of Cancer Research, Khayati and colleagues use state-of-the-art genetically engineered mouse models to demonstrate that transient systemic inhibition of autophagy can irreversibly impair the growth of established lung tumors with a good tolerability in normal tissues, suggesting a therapeutic strategy for cancer treatment.

Treatment Of Epilepsy Using A Targeted P38Γ Kinase Gene Therapy, Nicolle Morey, Magdalena Przybyla, Julia Van Der Hoven, Yazi D Ke, Fabien Delerue, Janet Van Eersel, Lars M Ittner

Faculty, Staff and Student Publications

Hyperphosphorylated microtubule-associated protein tau has been implicated in dementia, epilepsy, and other neurological disorders. In contrast, site-specific phosphorylation of tau at threonine 205 (T205) by the kinase p38γ was shown to disengage tau from toxic pathways, serving a neuroprotective function in Alzheimer's disease. Using a viral-mediated gene delivery approach in different mouse models of epilepsy, we show that p38γ activity-enhancing treatment reduces seizure susceptibility, restores neuronal firing patterns, reduces behavioral deficits, and ameliorates epilepsy-induced deaths. Furthermore, we show that p38γ-mediated phosphorylation of tau at T205 is essential for this protection in epilepsy, as a lack of this critical interaction reinstates …

Who Has The Right To Pull The Plug?, Laila El Baradei

Faculty Journal Articles

No abstract provided.

Utilization Of Gis In Tracking Disinterment And Movement Of Unknown Us Wwii War Dead: Foundations For A Geospatial Approach To Addressing Commingled Remains, Ella Axelrod

Department of Anthropology: Theses and Student Research

In the aftermath of World War II, the US was faced with the monumental task of finding and identifying over 405,000 service members who did not survive the conflict (McDermott, 2005, p. 1). Of these 405,000, 81,000 remain missing and 2,498 remain unidentified in cemeteries across Europe alone (American Battle Monuments Commission, 2022). Often, these individuals were interred and disinterred multiple times, crossing the continent in the journey from loss incident or battlefield to their final resting place. Commingling, the accidental mixing of remains, is an ever-present concern in the forensic identification of individuals from mass casualty incidents (Belcher et …

Georgia Southern University Fact Book, Georgia Southern University

Georgia Southern Fact Books (1976-2022)

No abstract provided.

Quaker Campus, December 02, 2022 (Vol. 20, Issue 6), Whittier College

Quaker Campus

No abstract provided.

Hyperkalemia And Electrocardiogram Manifestations In End-Stage Renal Disease, Zubaid Rafique, Bryan Hoang, Heba Mesbah, Ryan Pappal, Frank W Peacock, Raul Juarez-Vela, Lukasz Szarpak, Dick C Kuo

Faculty, Staff and Students Publications

Hyperkalemia is one of the more common acute life-threatening metabolic emergencies. The aim of our study is to determine the correlation and accuracy of abnormal ECG parameters as a function of serum potassium concentration in the end-stage renal disease (ESRD) population. We performed a retrospective chart review of emergency department patients presenting with ESRD and receiving emergent hemodialysis treatment. A total of 96 patients, each with five independent ED visits, provided 480 sets of ECGs and electrolytes. Of these, four ECGs were excluded for inability to interpret, leaving a total of 476 patient encounters that met all inclusion criteria. Linear …

Association Of Maternal Age 35 Years And Over And Prenatal Care Utilization, Preterm Birth, And Low Birth Weight, Mexico 2008–2019, Laura Jacobson, Evelyn Fuentes-Rivera, Raffaela Schiavon, Blair Darney

OHSU-PSU School of Public Health Faculty Publications and Presentations

Objective:

We compared prenatal care utilization, preterm birth, and low birth weight neonates among women 35 years and older compared to women 20-34 years old in Mexico, 2008-2019.

Methods:

We used birth certificate data and conducted a historical cohort study of all singleton live births in Mexico from 2008-2019. Study outcomes were inadequate prenatal care (timing of initiation of care and number of visits), preterm birth, and low birth weight. We compared outcomes among women 35-39, 40-44, and 45-49 with births to women 20-34. We used logistic regression to account for individual and contextual confounders.

Results:

We included a total …

Sitting Time And Insulin Resistance In 6,931 United States Adults: The Role Of Abdominal Adiposity, Kayla Marie Parker

Theses and Dissertations

This cross-sectional investigation of 6,931 U.S. adults examined the relationship between sitting time and insulin resistance. A primary objective was to evaluate how this relationship was mediated by the following variables: age, sex, race, year of assessment, cigarette smoking, physical activity, body mass index (BMI), and waist circumference. Self-reported sitting time, measured in minutes per day, was the exposure variable. Insulin resistance, indexed by the homeostatic model assessment of insulin resistance (HOMA-IR), was the outcome variable. Data were used from the 2011-2018 National Health and Nutrition Examination Survey (NHANES). Results showed a strong, positive association between sitting time and insulin …

Active Dna Demethylation Promotes Cell Fate Specification And The Dna Damage Response, Dongpeng Wang, Wei Wu, Elsa Callen, Raphael Pavani, Nicholas Zolnerowich, Srikanth Kodali, Dali Zong, Nancy Wong, Santiago Noriega, William J Nathan, Gabriel Matos-Rodrigues, Raj Chari, Michael J Kruhlak, Ferenc Livak, Michael Ward, Keith Caldecott, Bruno Di Stefano, André Nussenzweig

Faculty, Staff and Students Publications

Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to neuronal enhancers, but the source of this endogenous damage remains unclear. Using two systems of postmitotic lineage specification-induced pluripotent stem cell-derived neurons and transdifferentiated macrophages-we show that thymidine DNA glycosylase (TDG)-driven excision of methylcytosines oxidized with ten-eleven translocation enzymes (TET) is a source of SSBs. Although macrophage differentiation favors short-patch base excision repair to fill in single-nucleotide gaps, neurons also frequently use the long-patch subpathway. Disrupting this gap-filling process using anti-neoplastic cytosine analogs triggers a DNA damage response and neuronal cell death, which is dependent on TDG. …

2022-2023 Performance Forum - December 2, 2022, Benjamin Shaposhnikov, Juan Diaz Quijano, Luis Pulido, Jafet Diaz, Matthew Montelione, Daniel Meneses Leal, Youbeen Cho, Zhanbota Balgabekov, Graydon Howard, William Penn, Sergei Skobin, Vincent Cart-Sanders, Sheng Yuan Kuan, Olivia Oakland, Paula Mora Alfaro, Ryan Aguilar, Isaiah Obey, Lauren Washburn, Keegan Neely, Gioia Gedicks, Victoria Bramble, Daniel Guevara, Megan Savage

Performance Forum

No abstract provided.

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

On Moments Of Certain Families Of L-Functions, Gopal Maiti

Doctoral Theses

In this thesis, I described the notion of moments of L-functions in some families. Then I discussed some problems on estimating moments of L-functions. As applications, I showed some simultaneous non-vanishing and correlation results of certain product L-functions over number fields as well as function fields.

Upper Temperature Limit Of Larval Pacifc Lamprey Entosphenus Tridentatus: Implications For Conservation In A Warming Climate, Timothy A. Whitesel, Christina T. Uh

Biology Faculty Publications and Presentations

Climate models suggest that by 2100, maximum temperatures where many larval Pacific lamprey, Entosphenus tridentatus, rear now may approach 27–31 °C. Little information exists on whether larval Pacific lamprey can tolerate these temperatures. We used acclimated chronic exposure (ACE) and direct acute exposure (DAE) experiments to determine the water temperature that is lethal to larval Pacific lamprey and whether sublethal water temperatures influence larval burrowing behavior. After 30 days in ACE experiments, all larvae survived in temperatures averaging ≤ 27.7 °C, no larvae survived in temperatures averaging ≥ 30.7 °C and the ultimate upper incipient lethal temperature (UILT) was …

Local Well-Posedness Of The Cauchy Problem For A P -Adic Nagumo-Type Equation, L. F. Chacón-Cortés, C. A. Garcia-Bibiano, Wilson A. Zuniga-Galindo

School of Mathematical & Statistical Sciences Faculty Publications

We introduce a new family of p -adic nonlinear evolution equations. We establish the local well-posedness of the Cauchy problem for these equations in Sobolev-type spaces. For a certain subfamily, we show that the blow-up phenomenon occurs and provide numerical simulations showing this phenomenon.