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Articles 167731 - 167760 of 167784
Full-Text Articles in Entire DC Network
On Sir David Cox's Publications, Mario Cortina Borja, Julian Stander, Giovanni Sebastiani
On Sir David Cox's Publications, Mario Cortina Borja, Julian Stander, Giovanni Sebastiani
School of Engineering, Computing and Mathematics
No abstract provided.
Fea Modelling And Environmental Assessment Of A Thin-Walled Composite Drive Shaft, Joseph Searle, Maozhou Meng, John Summerscales
Fea Modelling And Environmental Assessment Of A Thin-Walled Composite Drive Shaft, Joseph Searle, Maozhou Meng, John Summerscales
School of Engineering, Computing and Mathematics
Fibre reinforced plastics (FRP) composites have been widely used in the automotive industry with the primary focus on reduced mass. However, there are relatively few reports on their application on power transmission components, such as drive shafts. This paper explores the feasibility of replacing the traditional structural steel by light weight FRP composites in a drive shaft. Three FRP composites are considered against a steel drive shaft; basalt/epoxy, carbon/epoxy, and CNT (carbon nanotubes) reinforced carbon/epoxy composites. The mechanical performance was analysed by finite element analysis (FEA) tool and classical laminate theory (CLT), while the environmental performance was evaluated by life …
Book Review: The Guitar: Tracing The Grain Back To The Tree, P Simpson
Book Review: The Guitar: Tracing The Grain Back To The Tree, P Simpson
School of Geography, Earth and Environmental Sciences
No abstract provided.
Responding To Eruptive Transitions During The 2020–2021 Eruption Of La Soufrière Volcano, St. Vincent, E. P. Joseph, M. Camejo-Harry, T. Christopher, R. Contreras-Arratia, S. Edwards, O. Graham, M. Johnson, A. Juman, J. L. Latchman, L. Lynch, V. L. Miller, I. Papadopoulos, K. Pascal, R. Robertson, G. A. Ryan, A. Stinton, R. Grandin, I. Hamling, M. J. Jo, J. Barclay, P. Cole, B. V. Davies, R. S.J. Sparks
Responding To Eruptive Transitions During The 2020–2021 Eruption Of La Soufrière Volcano, St. Vincent, E. P. Joseph, M. Camejo-Harry, T. Christopher, R. Contreras-Arratia, S. Edwards, O. Graham, M. Johnson, A. Juman, J. L. Latchman, L. Lynch, V. L. Miller, I. Papadopoulos, K. Pascal, R. Robertson, G. A. Ryan, A. Stinton, R. Grandin, I. Hamling, M. J. Jo, J. Barclay, P. Cole, B. V. Davies, R. S.J. Sparks
School of Geography, Earth and Environmental Sciences
Abstract: A critical challenge during volcanic emergencies is responding to rapid changes in eruptive behaviour. Actionable advice, essential in times of rising uncertainty, demands the rapid synthesis and communication of multiple datasets with prognoses. The 2020–2021 eruption of La Soufrière volcano exemplifies these challenges: a series of explosions from 9–22 April 2021 was preceded by three months of effusive activity, which commenced with a remarkably low level of detected unrest. Here we show how the development of an evolving conceptual model, and the expression of uncertainties via both elicitation and scenarios associated with this model, were key to anticipating this …
Emotions, Psychological Safety And Recommendations For Designing Remediation Programmes, Nicola Brennan
Emotions, Psychological Safety And Recommendations For Designing Remediation Programmes, Nicola Brennan
Peninsula Medical School
This commentary presents emotion recognition and enabling psychological safety as crucial in the design of effective remediation programmes.
Adaptation Of The Stride Dementia Survey Into The Indonesian Context In North Sumatra, Fasihah Irfani Fitri, Ika Mariana Gultom, Eka Mahendrayana, Engki Irawan, Aldy S. Rambe, Tara Puspitarini Sani, Yuda Turana, Imelda Theresia, Nicolas Farina, Sube Banerjee
Adaptation Of The Stride Dementia Survey Into The Indonesian Context In North Sumatra, Fasihah Irfani Fitri, Ika Mariana Gultom, Eka Mahendrayana, Engki Irawan, Aldy S. Rambe, Tara Puspitarini Sani, Yuda Turana, Imelda Theresia, Nicolas Farina, Sube Banerjee
Peninsula Medical School
Background: North Sumatra is one of two provinces in Indonesia in which the prevalence and costs of care of dementia has been completed as part of the STrengthening Responses to dementia In Developing countries (STRiDE) program. The toolkit used in the study was developed in English and thus needed to be cross-culturally adapted into Bahasa Indonesia. Part of this process involved pre-testing as a way to maximize the cultural appropriateness of the toolkit, especially in a multi- ethnic province like North Sumatra. Here we report the adaptation process. Methods: The translated toolkit consisted of measures needed within the prevalence survey …
Heat Shock Protein Amplification Improves Cerebellar Myelination In The Npc1nih Mouse Model, James Gray, María E. Fernández-Suárez, Maysa Falah, D Smith, C Smith, Ecem Kaya, Ashley M. Palmer, Cathrine K. Fog, Thomas Kirkegaard, Frances M. Platt
Heat Shock Protein Amplification Improves Cerebellar Myelination In The Npc1nih Mouse Model, James Gray, María E. Fernández-Suárez, Maysa Falah, D Smith, C Smith, Ecem Kaya, Ashley M. Palmer, Cathrine K. Fog, Thomas Kirkegaard, Frances M. Platt
Peninsula Medical School
BACKGROUND: Niemann-Pick disease type C (NPC) is a rare prematurely fatal lysosomal lipid storage disease with limited therapeutic options. The prominent neuropathological hallmarks include hypomyelination and cerebellar atrophy. We previously demonstrated the efficacy of recombinant human heat shock protein 70 (rhHSP70) in preclinical models of the disease. It reduced glycosphingolipid levels in the central nervous system (CNS), improving cerebellar myelination and improved behavioural phenotypes in Npc1nih (Npc1-/-) mice. Furthermore, treatment with arimoclomol, a well-characterised HSP amplifier, attenuated lysosomal storage in NPC patient fibroblasts and improved neurological symptoms in Npc1-/- mice. Taken together, these findings prompted the investigation of the effects …
Informing Versus Generating A Discussion: Comparing Two Approaches To Encouraging Mitigation Of Soil Erosion Among Maasai Pastoralists, Anna Rabinovich, Vladimir Zhischenko, Mona Nasseri, Stacey C. Heath, Alpha Laizer, Francis Mkilema, Aloyce Patrick, Maarten Wynants, William H. Blake, Kelvin Mtei, Patrick Ndakidemi
Informing Versus Generating A Discussion: Comparing Two Approaches To Encouraging Mitigation Of Soil Erosion Among Maasai Pastoralists, Anna Rabinovich, Vladimir Zhischenko, Mona Nasseri, Stacey C. Heath, Alpha Laizer, Francis Mkilema, Aloyce Patrick, Maarten Wynants, William H. Blake, Kelvin Mtei, Patrick Ndakidemi
School of Geography, Earth and Environmental Sciences
Soil erosion is a critical problem for pastoralist societies that rely on healthy grazing land for their livelihoods. Previous research suggests that unsustainable land management practice is one of the factors exacerbating soil erosion, and that willingness to adjust this practice is closely linked to community land protection norms. The present research explores approaches to building stronger community norms and intentions linked to mitigating soil erosion among Maasai pastoralists in Northern Tanzania. In particular, we compare two impact approaches based on the information deficit model (exposure to scientific information) and the social identity framework (a group-based discussion). The results demonstrate …
Real-World Smartphone-Based Gait Recognition, Hind Alobaidi, Nathan Clarke, Fudong Li, Abdulrahmanalruban
Real-World Smartphone-Based Gait Recognition, Hind Alobaidi, Nathan Clarke, Fudong Li, Abdulrahmanalruban
School of Engineering, Computing and Mathematics
No abstract provided.
Evaluation Of Small‐Scale Yielding Boundary Using Digital Image Correlation Results, Jm Vasco‐Olmo, Fa Díaz, Dm Neto, Er Sérgio, Fv Antunes, Mn James
Evaluation Of Small‐Scale Yielding Boundary Using Digital Image Correlation Results, Jm Vasco‐Olmo, Fa Díaz, Dm Neto, Er Sérgio, Fv Antunes, Mn James
School of Engineering, Computing and Mathematics
No abstract provided.
Assessment Of Equivalent Substrate Stiffness And Mechanical Properties Of Sustainable Alkali-Activated Concrete Containing Recycled Concrete Aggregate, Nattapong Damrongwiriyanupap, Todsaporn Srikhamma, Chittinat Plongkrathok, Tanakorn Phoo-Ngernkham, Worathep Sae-Long, Sakonwan Hanjitsuwan, Piti Sukontasukkul, Long Yuan Li, Prinya Chindaprasirt
Assessment Of Equivalent Substrate Stiffness And Mechanical Properties Of Sustainable Alkali-Activated Concrete Containing Recycled Concrete Aggregate, Nattapong Damrongwiriyanupap, Todsaporn Srikhamma, Chittinat Plongkrathok, Tanakorn Phoo-Ngernkham, Worathep Sae-Long, Sakonwan Hanjitsuwan, Piti Sukontasukkul, Long Yuan Li, Prinya Chindaprasirt
School of Engineering, Computing and Mathematics
The effects of using recycled concrete aggregate (RCA) as coarse aggregate on the equivalent substrate stiffness and mechanical properties of sustainable alkali-activated concrete were investigated in this paper. High-calcium fly ash (HFA) and commercial silica fume (SF) were used as the precursors for producing the alkali-activated high-calcium fly ash concrete (AAHFAC). Sodium hydroxide (SH) and sodium silicate (SS) solutions were used as alkaline activator solutions with the constant SS/SH ratio of 1.0 and liquid-binder (L/B) ratio of 0.50. The natural coarse aggregate (NCA) used in this study was crushed limestone and replaced with RCA at the rates of 0%, 20%, …
Combined Approach For Fatigue Crack Characterisation In Metals, Jm Robles, Jm Vasco-Olmo, As Cruces, Fa Diaz, Mn James, P Lopez-Crespo
Combined Approach For Fatigue Crack Characterisation In Metals, Jm Robles, Jm Vasco-Olmo, As Cruces, Fa Diaz, Mn James, P Lopez-Crespo
School of Engineering, Computing and Mathematics
No abstract provided.
Characterization Of Non‐Planar Crack Tip Displacement Fields Using A Differential Geometry Approach In Combination With 3d Digital Image Correlation, A Camacho‐Reyes, Jm Vasco‐Olmo, Mn James, Fa Diaz
Characterization Of Non‐Planar Crack Tip Displacement Fields Using A Differential Geometry Approach In Combination With 3d Digital Image Correlation, A Camacho‐Reyes, Jm Vasco‐Olmo, Mn James, Fa Diaz
School of Engineering, Computing and Mathematics
No abstract provided.
Modelling Of Convection, Diffusion And Binding Of Chlorides In Concrete During Wetting-Drying Cycles, Long-Yuan Li, Dawang Li, Ping Li, Yao-Cheng Wang
Modelling Of Convection, Diffusion And Binding Of Chlorides In Concrete During Wetting-Drying Cycles, Long-Yuan Li, Dawang Li, Ping Li, Yao-Cheng Wang
School of Engineering, Computing and Mathematics
Moisture convection in concrete is an important factor affecting the chloride diffusion in concrete. This paper presents a comprehensive study on the transport of moisture, carbon dioxide and chloride ions in concrete when subjected to wetting and drying cycles. A numerical model considering not only the transport of individual components but also the interaction between them is developed. The latter includes the concrete carbonation, chloride binding, the effect of concrete carbonation on chloride binding capacity, and the time-varying boundary conditions of carbon dioxide and chloride caused due to wetting and/or drying. The results obtained from the study demonstrate that when …
Towards A New Methodology For The Characterisation Of Crack Tip Fields Based On A Hybrid Computational Approach, A Camacho-Reyes, Jm Vasco-Olmo, Mn James, Fa Diaz
Towards A New Methodology For The Characterisation Of Crack Tip Fields Based On A Hybrid Computational Approach, A Camacho-Reyes, Jm Vasco-Olmo, Mn James, Fa Diaz
School of Engineering, Computing and Mathematics
No abstract provided.
Embrittlement Failure Of 51crv4 Leaf Springs, Mn James, Dg Hattingh, L Matthews
Embrittlement Failure Of 51crv4 Leaf Springs, Mn James, Dg Hattingh, L Matthews
School of Engineering, Computing and Mathematics
High strength quenched and tempered alloys are used in the manufacture of leaf springs, and peening techniques are used to induce compressive residual stresses on the tension surface of the individual leaves to resist fatigue crack growth. However, the extent of such residual stresses is usually limited to around 0.1–0.2 mm deep. Their beneficial effect can therefore be negated by corrosion pitting, while high strength steels are known to also be susceptible to environmental embrittlement in high chloride environments. This case study deals with an interesting example of environmental embrittlement of multileaf springs reportedly made from 60Si2Mn steel, but actually …
Analysis Of Electrical Conductivity Of Carbon Nanotube-Reinforced Two-Phase Composites, Z Li, L-Y Li
Analysis Of Electrical Conductivity Of Carbon Nanotube-Reinforced Two-Phase Composites, Z Li, L-Y Li
School of Engineering, Computing and Mathematics
No abstract provided.
Surface Quality Augmentation For Metalworking Industry With Pix2pix, Dirk Hölscher, Christoph Reich, Martin Knahl, Frank Gut, Nathan Clarke
Surface Quality Augmentation For Metalworking Industry With Pix2pix, Dirk Hölscher, Christoph Reich, Martin Knahl, Frank Gut, Nathan Clarke
School of Engineering, Computing and Mathematics
No abstract provided.
Consumer Engagement At The Uea: Deliverable 5.1, Ian Bailey, Gina Kallis, Phedeas Stephanides, Konstantinos Chalvatis
Consumer Engagement At The Uea: Deliverable 5.1, Ian Bailey, Gina Kallis, Phedeas Stephanides, Konstantinos Chalvatis
School of Geography, Earth and Environmental Sciences
No abstract provided.
Real Talk: A Realist Dialogic Approach In A Realist Evaluation, Emilie Francis-Auton, Mitchell N. Sarkies, Chiara Pomare, Janet C. Long, Rebecca Hardwick, Hoa Mi Nguyen, Jeffrey Braithwaite
Real Talk: A Realist Dialogic Approach In A Realist Evaluation, Emilie Francis-Auton, Mitchell N. Sarkies, Chiara Pomare, Janet C. Long, Rebecca Hardwick, Hoa Mi Nguyen, Jeffrey Braithwaite
Peninsula Medical School
Realist evaluation is a method increasingly adopted to provide an understanding of how and why a program works, for whom, and under what circumstances. Initial program theories (IPT) are the crucial starting point of any realist evaluation, however descriptions about how they are developed in practice remain under-reported in the published literature. This article argues for the value of genuine research-group conversations using David Bohm’s concept of dialogue in realist research. We label it the realist dialogic approach. We draw out the relational qualities as well as the contextual circumstances of dialogue through our development of IPT and interview guides …
Deprescribing Medicines In Older People Living With Multimorbidity And Polypharmacy: The Tailor Evidence Synthesis, Joanne Reeve, Michelle Maden, Ruaraidh Hill, Amadea Turk, Kamal Mahtani, Geoff Wong, Dan Lasserson, Janet Krska, Dee Mangin, Richard Byng, Emma Wallace, Ed Ranson
Deprescribing Medicines In Older People Living With Multimorbidity And Polypharmacy: The Tailor Evidence Synthesis, Joanne Reeve, Michelle Maden, Ruaraidh Hill, Amadea Turk, Kamal Mahtani, Geoff Wong, Dan Lasserson, Janet Krska, Dee Mangin, Richard Byng, Emma Wallace, Ed Ranson
Peninsula Medical School
Background Tackling problematic polypharmacy requires tailoring the use of medicines to individual needs and circumstances. This may involve stopping medicines (deprescribing) but patients and clinicians report uncertainty on how best to do this. The TAILOR medication synthesis sought to help understand how best to support deprescribing in older people living with multimorbidity and polypharmacy. Objectives We identified two research questions: (1) what evidence exists to support the safe, effective and acceptable stopping of medication in this patient group, and (2) how, for whom and in what contexts can safe and effective tailoring of clinical decisions related to medication use work …
Self-Management Intervention To Reduce Pulmonary Exacerbations By Supporting Treatment Adherence In Adults With Cystic Fibrosis: A Randomised Controlled Trial, Cfhealthhub Study Team, Martin J. Wildman, Alicia O’Cathain, Chin Maguire, Madelynne A. Arden, Marlene Hutchings, Judy Bradley, Stephen J. Walters, Pauline Whelan, John Ainsworth, Iain Buchan, Laura Mandefield, Laura Sutton, Paul Tappenden, Rachel A. Elliott, Zhe Hui Hoo, Sarah J. Drabble, Daniel Beever, H. Cantrill, J. Nicholl, S. Michie, S. Waterhouse, L. Robinson, A. Scott, S. Antrobus, E. Lumley, A. N. Biz, D. Hind, C. Orchard
Self-Management Intervention To Reduce Pulmonary Exacerbations By Supporting Treatment Adherence In Adults With Cystic Fibrosis: A Randomised Controlled Trial, Cfhealthhub Study Team, Martin J. Wildman, Alicia O’Cathain, Chin Maguire, Madelynne A. Arden, Marlene Hutchings, Judy Bradley, Stephen J. Walters, Pauline Whelan, John Ainsworth, Iain Buchan, Laura Mandefield, Laura Sutton, Paul Tappenden, Rachel A. Elliott, Zhe Hui Hoo, Sarah J. Drabble, Daniel Beever, H. Cantrill, J. Nicholl, S. Michie, S. Waterhouse, L. Robinson, A. Scott, S. Antrobus, E. Lumley, A. N. Biz, D. Hind, C. Orchard
Peninsula Medical School
Introduction Recurrent pulmonary exacerbations lead to progressive lung damage in cystic fibrosis (CF). Inhaled medications (mucoactive agents and antibiotics) help prevent exacerbations, but objectively measured adherence is low. We investigated whether a multi-component (complex) self-management intervention to support adherence would reduce exacerbation rates over 12 months. Methods Between October 2017 and May 2018, adults with CF (aged ≥16 years; 19 UK centres) were randomised to the intervention (data-logging nebulisers, a digital platform and behavioural change sessions with trained clinical interventionists) or usual care (data-logging nebulisers). Outcomes included pulmonary exacerbations (primary outcome), objectively measured adherence, body mass index (BMI), lung function …
Predictors And Determinants Of Albuminuria In People With Prediabetes And Diabetes Based On Smoking Status: A Cross-Sectional Study Using The Uk Biobank Data, Debasish Kar, Aya El-Wazir, Gayathri Delanerolle, Anna Forbes, James P. Sheppard, Mintu Nath, Mark Joy, Nicholas Cole, J. Ranjit Arnold, Andrew Lee, Michael Feher, Melanie J. Davies, Kamlesh Khunti, Simon De Lusignan, Elizabeth Goyder
Predictors And Determinants Of Albuminuria In People With Prediabetes And Diabetes Based On Smoking Status: A Cross-Sectional Study Using The Uk Biobank Data, Debasish Kar, Aya El-Wazir, Gayathri Delanerolle, Anna Forbes, James P. Sheppard, Mintu Nath, Mark Joy, Nicholas Cole, J. Ranjit Arnold, Andrew Lee, Michael Feher, Melanie J. Davies, Kamlesh Khunti, Simon De Lusignan, Elizabeth Goyder
Peninsula Medical School
No abstract provided.
Resilient Placement Of Vnfs And Distributed Mano Components In A Wmn-Based Nfv Infrastructure, G Frick, U Trick, A Lehmann, B Ghita
Resilient Placement Of Vnfs And Distributed Mano Components In A Wmn-Based Nfv Infrastructure, G Frick, U Trick, A Lehmann, B Ghita
School of Engineering, Computing and Mathematics
No abstract provided.
A Nation That Rebuilds Its Soils Rebuild Itself- An Engineer's Perspective, Karen L. Johnson, Neil D. Gray, Wendy Stone, Bryce F.J. Kelly, Mark F. Fitzsimons, Cathy Clarke, Lynsay Blake, Stephen Chivasa, Florence Mtambanengwe, Paul Mapfumo, Andy Baker, Sabrina Beckmann, Lena Dominelli, Andrew L. Neal, Tariro Gwandu
A Nation That Rebuilds Its Soils Rebuild Itself- An Engineer's Perspective, Karen L. Johnson, Neil D. Gray, Wendy Stone, Bryce F.J. Kelly, Mark F. Fitzsimons, Cathy Clarke, Lynsay Blake, Stephen Chivasa, Florence Mtambanengwe, Paul Mapfumo, Andy Baker, Sabrina Beckmann, Lena Dominelli, Andrew L. Neal, Tariro Gwandu
School of Geography, Earth and Environmental Sciences
Nations can build and rebuild degraded soils to help address climate change and potentially improve the nutritional content of food if we change policies that allow the addition of safe mineral and organic wastes to soil. We present a framework that facilitates the transition from intensive conventional to more regenerative farming practices by considering soil’s natural cycle. Our paper is presented in three parts. Firstly, we consider that ’soil is living’; just like humans, the soil biome needs a balanced diet of macro and micronutrients as well as a nurturing environment. We simplify the soil science and take a systems …
A Review Of The Pharmacotherapeutic Considerations For Managing Epilepsy In People With Autism, Lance V. Watkins, Maire O’Dwyer, Rohit Shankar
A Review Of The Pharmacotherapeutic Considerations For Managing Epilepsy In People With Autism, Lance V. Watkins, Maire O’Dwyer, Rohit Shankar
Peninsula Medical School
Introduction: Autism, like other neurodevelopmental disorders (NDDs), has a strong association with epilepsy. There are known common genetic pathways in both autism and epilepsy. There are also specific genetic syndromes associated with both complex epilepsy and the autism phenotype. Areas covered: This review explores the evidence for common genetic etiologies and pathophysiological pathways in relation to both epilepsy and autism. Autism with comorbid epilepsy are associated with a high prevalence of medical and psychiatric comorbidities. This paper discusses how this influences assessment, treatment, and outcomes. The evidence for the treatment of specific seizure types in the context of NDDs is …
Impact Of Water-Sediment Diversion And Afflux On Erosion-Deposition In The Luoshan-Hankou Reach, Middle Yangtze River, China, Boyuan Zhu, Jianhao Qin, Yitian Li, Gexuanzi Luo, Qi Xu, Lingfeng Liu, Alistair G.L. Borthwick
Impact Of Water-Sediment Diversion And Afflux On Erosion-Deposition In The Luoshan-Hankou Reach, Middle Yangtze River, China, Boyuan Zhu, Jianhao Qin, Yitian Li, Gexuanzi Luo, Qi Xu, Lingfeng Liu, Alistair G.L. Borthwick
School of Engineering, Computing and Mathematics
It is not yet fully understood how water-sediment diversion and afflux along a mainstream reach of a river affect erosion-deposition in downstream reaches. This study focuses on the Luoshan-Hankou mainstream reach of the middle Yangtze River, China. The Luoshan-Hankou reach is vitally important for flood control, being located downstream of three diversion mouths and an afflux outlet along the Jingjiang reach. We establish empirical formulae for sediment transport rates at boundary cross-sections, and hence estimate the amount and proportion of erosion-deposition and its relative increase (termed erosion-deposition promotion) in the Luoshan-Hankou reach. We then propose critical net water supplies from …
Human Affinity For Rivers, Yichu Wang, Alistair G.L. Borthwick, Jinren Ni
Human Affinity For Rivers, Yichu Wang, Alistair G.L. Borthwick, Jinren Ni
School of Engineering, Computing and Mathematics
Human civilization prospers along rivers worldwide. Here, we investigated human–river relations by revealing the linkage between water and habitability for human settlements, and socioeconomic and cultural development across China. We found that human–water co-occurrence relationships are self-similar over sub-basins for different scales of stream-order in the river networks. According to the earlier complete demographic census conducted during the reign of the Qing Dynasty (1776), there has been a general tendency for inhabitants to live close to rivers, characterized by population density associated with habitability cored by water under a near-natural state, which still remains to date (2019) even after long-term …
Adapting And Validating The Autism Diagnostic Observation Schedule Version 2 For Use With Deaf Children And Young People, Barry Wright, Helen Phillips, Victoria Allgar, Helen Mcconachie, Jennifer Sweetman, Rebecca Hargate, Rachel Hodkinson, Martin Bland, Hannah George, Anna Hughes, Emily Hayward, Las Heras Vfg De, Couteur A Le
Adapting And Validating The Autism Diagnostic Observation Schedule Version 2 For Use With Deaf Children And Young People, Barry Wright, Helen Phillips, Victoria Allgar, Helen Mcconachie, Jennifer Sweetman, Rebecca Hargate, Rachel Hodkinson, Martin Bland, Hannah George, Anna Hughes, Emily Hayward, Las Heras Vfg De, Couteur A Le
Peninsula Medical School
We report a Delphi Consensus modification and first validation study of the Autism Diagnostic Observation Schedule – 2 with deaf children and young people (ADOS-2 Deaf adaptation). Validation included 122 deaf participants (aged 2–18 years), 63 with an Autism Spectrum Disorder (ASD). This was compared to a National Institute for Health and Clinical Excellence (NICE) guideline standard clinical assessment by blinded independent specialist clinicians. Results showed overall sensitivity 73% (95%CI 60%, 83%); specificity 71% (95%CI 58%, 82%), and for the more common modules 1–3 (combined as in previous studies) sensitivity 79% (95% CI 65–89%); specificity 79% (95% CI 66–89%) suggesting …
Adapting And Validating The Autism Diagnostic Interview - Revised For Use With Deaf Children And Young People, Barry Wright, Helen Phillips, Victoria Allgar, Jennifer Sweetman, Rachel Hodkinson, Emily Hayward, Amelia Ralph-Lewis, Catarina Teige, Martin Bland, Couteur A Le
Adapting And Validating The Autism Diagnostic Interview - Revised For Use With Deaf Children And Young People, Barry Wright, Helen Phillips, Victoria Allgar, Jennifer Sweetman, Rachel Hodkinson, Emily Hayward, Amelia Ralph-Lewis, Catarina Teige, Martin Bland, Couteur A Le
Peninsula Medical School
A Delphi consensus methodology was used to adapt the Autism Diagnostic Interview–Revised for the assessment of deaf children with suspected autism spectrum disorder. Each Autism Diagnostic Interview–Revised item was considered by a panel of nine international experts in terms of relevance and acceptability. Modifications were proposed and agreed by the expert panel for 45% of items. The pre-specified criterion for agreement between experts was set at 80% for each item. A first validation of the revised version, adapted for deaf children (Autism Diagnostic Interview–Revised Deaf Adaptation), was undertaken with a UK sample of 78 parents/carers of deaf children with autism …