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2022

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The Cardinality Of The Permutations On A Set With N Non-Fixed Points, Jukkrid Nuntasri Jan 2022

The Cardinality Of The Permutations On A Set With N Non-Fixed Points, Jukkrid Nuntasri

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this thesis, we study relationships between |Sn(A)| and |seqn1-1(A)| as well as |seqn(A)| for infinite sets A, where Sn(A) is the set of permutations of A with n non-fixed points and seqn(A) and seqn1-1(A) are the set of sequences and the set of one-to-one sequences of elements of A with length n, respectively, where n is a natural number greater than 1. With the Axiom of Choice (AC), |Sn(A)|, |seqn1-1(A)|, and |seqn(A)| are equal for all infinite sets A. Among our results, we show, in the Zermelo-Fraenkel set theory (ZF), that |Sn(A)|<=|seqn1-1(A)| for any infinite set A under some weak form of AC and the assumption cannot be removed. In the other direction, we show that |seqn1-1(A)|<=|Sn+1(A)| for any infinite set A and the subscript n+1 cannot be reduced to n. Moreover, we also show that "|Sn(A)|<=|Sn+1(A)| for any infinite set A" is not provable in ZF.

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Valuation Of American Commodity Options, Piyapoom Nonsoong Jan 2022

Valuation Of American Commodity Options, Piyapoom Nonsoong

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this dissertation, we present analytical option pricing formulas for European and American options in which the price dynamics of a risky asset follows a meanreverting process with time-dependent parameter. The process can be adapted to describe both nonseasonal and seasonal variation in price, especially, in commodity markets such as agricultural commodities. The formulas are derived based on the solutions of partial differential equations showing that the values of both European and American options can be decomposed into two parts: the payoff of the option at initial time and the time-integral over the lifetime of the option, which is driven …

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Threshold Numbers Of Some Complete Multipartite Graphs And Their Complements, Thanaporn Sumalroj Jan 2022

Threshold Numbers Of Some Complete Multipartite Graphs And Their Complements, Thanaporn Sumalroj

Chulalongkorn University Theses and Dissertations (Chula ETD)

No abstract provided.

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Development Of Stiffness Sensing And Adaptive Grasping With Soft Pneumatic Grippers, Chaiwuth Sithiwichankit Jan 2022

Development Of Stiffness Sensing And Adaptive Grasping With Soft Pneumatic Grippers, Chaiwuth Sithiwichankit

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study presents a framework for stiffness sensing and adaptive grasping using soft pneumatic grippers (SPGs). The motivation was to imitate the capabilities of human hands. The challenge was the compliance of soft pneumatic actuators (SPAs). The study associated the behaviors of grasped objects with those on SPAs, introduced a new concept of SPA modeling, and proposed a method for stiffness sensing through SPG pincer grasping. Compression testing was conducted for validation. A technique for forecasting deformation and force on grasped objects based on their stiffness was established, and a control law was elaborated. The presented technique and control architecture …

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Simulation And Prototyping Of A Knee Assistive Device For Improved Gait Function, Khemwutta Pornpipatsakul Jan 2022

Simulation And Prototyping Of A Knee Assistive Device For Improved Gait Function, Khemwutta Pornpipatsakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to develop a knee-assistive device while walking. The research was separated into two sections: the gait support simulation in MATLAB and the prototype of the device. Data on body part positions and ground reaction force were collected from three adult Thai participants walking at a speed of 1.5 m/s to calculate knee moment. The simulation section provides support moments during walking using machine learning and artificial stiffness control strategy (MLASCS), composed of the kNN model and the instantaneous artificial stiffness per body mass (IASPB) equations. The MLASCS was used to determine the proper amount of support moment …

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Exploring Roles Of Mir-885-5p In Hepatocellular Carcinoma, Archittapon Nokkeaw Jan 2022

Exploring Roles Of Mir-885-5p In Hepatocellular Carcinoma, Archittapon Nokkeaw

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, exerts a significant burden on Southeast Asian countries and stands as the third leading cause of cancer-related mortality worldwide. Despite this alarming impact, effective treatments for HCC are lacking, resulting in low survival rates and high recurrence rates. Therefore, a comprehensive understanding of the disease's underlying mechanisms is crucial for the development of novel and potent therapies. Recently, it has been recognized that microRNAs (miRNAs) play a vital role in tumorigenesis, including HCC. Our bioinformatic analysis has highlighted hsa-miR-885-5p as a potential candidate miRNA due to its downregulation in HCC …

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Exploring Roles Of Mir-372-3p In Proliferation Of Hepatocellular Carcinoma Cells, Pannathon Thamjamrassri Jan 2022

Exploring Roles Of Mir-372-3p In Proliferation Of Hepatocellular Carcinoma Cells, Pannathon Thamjamrassri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC has a replicative immortality and sustained proliferation rate. In addition, cell cycle-related protein regulating proliferation in cancer are often found dysregulated, allowing cancer cells to proceed their proliferation uncontrollably. Recently, a small non-coding RNA, microRNA (miRNA), was found to play an important role in numerous biological functions. Specific miRNA may ameliorate or promote cancer progression through different target mRNA. MiR-372-3p has been explored in various cancers such as colon cancer, colorectal cancer, and glioma. However, its functions have been rarely studied in HCC, especially in the aspect …

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Classification Of Bacteria And Fungi In Peritoneal Dialysis Fluids Of Patients With Chronic Kidney Disease Based On Metagenomic Analysis, Suthida Visedthorn Jan 2022

Classification Of Bacteria And Fungi In Peritoneal Dialysis Fluids Of Patients With Chronic Kidney Disease Based On Metagenomic Analysis, Suthida Visedthorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chronic kidney disease (CKD) is a long-term condition where sustained damage of the renal parenchyma leads to the chronic deterioration of renal function that may gradually progress to end-stage kidney disease (ESKD). Peritoneal dialysis (PD) is a type of ESKD treatment that is beneficial to improve a patient's quality of life. However, PD-associated peritonitis is a major complication that contributes cause of death, and the detection of the pathogen provided a high culture-negative rate. This study aims to apply metagenomic approaches for identifying the bacteria and fungi in peritoneal dialysis effluent (PDE) of CKD patients based on the full-length 16S …

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Effects Of Chitosan Oligosaccharide And Probiotics On Chronic Kidney Disease Rats, Weerapat Anegkamol Jan 2022

Effects Of Chitosan Oligosaccharide And Probiotics On Chronic Kidney Disease Rats, Weerapat Anegkamol

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chronic kidney disease (CKD) patients suffer from the accumulation of toxic substances in their blood due to the loss of kidney function, which results in hyperphosphatemia. This condition contributes to hyperparathyroidism, leading to the development of chronic kidney disease-related mineral bone disorder (CKD-MBD). Additionally, CKD patients experience changes in their gut microbiota, disrupting epithelial tight junctions and allowing excessive absorption of dietary phosphate. In this study, we aimed to investigate the effects of various oligosaccharides and probiotics on the gut microbiota, intestinal barrier, hyperphosphatemia, and hyperparathyroidism in CKD rats. We isolated Lactobacillus and Bifidobacterium strains from healthy participants and tested …

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Effects Of Different Serum Supplements On Piggybac Cd19 Chimeric Antigen Receptor T Cells, Mulita Sanyanusin Jan 2022

Effects Of Different Serum Supplements On Piggybac Cd19 Chimeric Antigen Receptor T Cells, Mulita Sanyanusin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chimeric Antigen Receptor (CAR) T cell is a novel therapy for relapse and refractory hematologic malignancy. Characteristics of CAR T cells is associated with clinical efficacy and toxicity. Type of serum supplements used during cultivation affect the immunophenotype and function of viral-based CAR T cells. This study explores the effect of serum supplements on non-viral piggyBac transposon CAR T cell production. PiggyBac CD19 CAR T cells were expanded in cultured conditions containing either fetal bovine serum, human AB serum, human platelet lysate or xeno-free serum replacement. Then, the effect of different serum supplements on cell expansion, transfection efficiency, immunophenotypes and …

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The Effect Of Histone Methylation In Trained Innate Immunity Of Cord Blood Monocytes In Newborn Infants Of Chronic Hbv-Infected Mothers, Pennapa Plypongsa Jan 2022

The Effect Of Histone Methylation In Trained Innate Immunity Of Cord Blood Monocytes In Newborn Infants Of Chronic Hbv-Infected Mothers, Pennapa Plypongsa

Chulalongkorn University Theses and Dissertations (Chula ETD)

Newborns contract Hepatitis B virus (HBV) through exposure in utero from mothers who are infected with HBV. In newborn infant from chronic HBV-infected mothers, the immune system displays innate immune cell maturation and enhances immune response upon restimulation with unrelated pathogens such as bacteria. This pattern is called “trained immunity” or “innate immune memory”. Trained immunity is regulated by epigenetic programming, especially histone modification. To date, there is not report on the epigenetics to regulate trained immunity in HBV. Therefore, this study investigated the cytokines levels and expression levels of histone modification enzyme genes in HBV-exposed cord blood monocytes. Moreover, …

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Study Of Thermodynamic Binding Between Ader And Ades In Two-Component Antibiotic Sensor Of Antibiotic Resistant Strains Of Acinetobacter Baumannii, Konrawee Thananon Jan 2022

Study Of Thermodynamic Binding Between Ader And Ades In Two-Component Antibiotic Sensor Of Antibiotic Resistant Strains Of Acinetobacter Baumannii, Konrawee Thananon

Chulalongkorn University Theses and Dissertations (Chula ETD)

The proteins AdeR (response regulator) and AdeS (histidine kinase sensor) play a crucial role in regulating the efflux pump, which is responsible for removing antibiotics from bacterial cells. This regulation occurs through a two-component regulatory system (TCS) involving autophosphorylation. Upon receiving external signals, AdeS undergoes autophosphorylation, leading to the activation of AdeR, which in turn initiates the expression of target genes related to the efflux pump. In this study, both enzymes from the reference strain of Acinetobacter baumannii (ATCC19606) and antibiotic resistant strains (H1074 and G560) were cloned and expressed in E. coli. The enzymes were purified using an immobilized …

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Macrophage Depletion Enhances Gut Dysbiosis And Severity In Sepsis Mouse Model, Pratsanee Hiengrach Jan 2022

Macrophage Depletion Enhances Gut Dysbiosis And Severity In Sepsis Mouse Model, Pratsanee Hiengrach

Chulalongkorn University Theses and Dissertations (Chula ETD)

Macrophage is vital players in the responsiveness of the innate immune system against injury or infection. Although macrophage depletion is well-known for some emerging therapies, such as osteoporosis, osteopenia, and decreasing tumor-associated macrophages in melanoma, dysfunction of macrophages leads to an inability of an appropriate immune response and implicated in various disease processes, especially intestinal macrophages that play a key role in the gut immune system and the regulation of gastrointestinal physiology. To obtain an understanding of the role of sepsis-associated macrophages, clodronate was used for the dysfunction of mouse macrophages with and without cecal ligation and puncture (CLP) sepsis. …

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Epigenetic Regulation In Trained And Tolerized Macrophages, Salisa Benjaskulluecha Jan 2022

Epigenetic Regulation In Trained And Tolerized Macrophages, Salisa Benjaskulluecha

Chulalongkorn University Theses and Dissertations (Chula ETD)

Innate immune memory is the phenomenon that can either enhance (trained) or suppress (tolerized) immune response by innate immune cells during the second encounter of the stimuli such as pathogens. Previous studies reported that epigenetic regulations critically regulate both types of innate immune memory. However, a complete understanding of the underlying mechanisms is still lacking. In this study, we performed a screening of an epigenetics compound library to identify inhibitors that affect ß-glucan (BG)-trained or LPS-tolerized macrophages. Among 181 compounds tested, various inhibitors targeting Aurora kinase, histone methyltransferase PRMT and EZH2, histone demethylase LSD1 and JMJD2, histone deacetylase 6 and …

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In Vivo Dosimetry Of 3d Gynecological Brachytherapy Using The Glass Dosimeter: A Phantom Study, Itsaraporn Konlak Jan 2022

In Vivo Dosimetry Of 3d Gynecological Brachytherapy Using The Glass Dosimeter: A Phantom Study, Itsaraporn Konlak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Brachytherapy can deliver high doses to the target while sparing healthy tissues due to its steep dose gradient property. However, treatment was only performed according to the dose calculated by a treatment planning system without verification of the dose due to the characteristics. Therefore, the aim of this study was to design the in-house phantom to evaluate the dosimetric differences of gynecological brachytherapy under clinical conditions between calculation by the treatment planning system and measurement by the RPLGDs. An in-house phantom consisting of the glass dosimeter holder and the holder of the applicator was created. This holder was designed to …

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Effect Of Inter-Observer Delineation Variability On Radiomics Features In Nasopharyngeal Cancer, Pongpitch Panyura Jan 2022

Effect Of Inter-Observer Delineation Variability On Radiomics Features In Nasopharyngeal Cancer, Pongpitch Panyura

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nasopharyngeal cancer (NPC) is a type of head and neck cancer that is prevalent in China and Southeast Asia. The standard treatment for NPC is radiation therapy (RT), which requires accurate target volume delineation (TVD) to ensure an effective radiation dose while minimizing damage to surrounding healthy tissues. However, TVD is subject to intra- and inter-observer variability, which can affect the accuracy of RT and lead to unstable results in radiomics analysis. Radiomics is a technique that extracts quantitative data from medical images, but it is currently limited by the manual process of tumor delineation. This study aims to investigate …

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Dosimetric Differences Between Scheduled And Adapted Plans Generated From Ethos Adaptive Radiotherapy For Patients With Prostate Cancer, Sarita Suvira Jan 2022

Dosimetric Differences Between Scheduled And Adapted Plans Generated From Ethos Adaptive Radiotherapy For Patients With Prostate Cancer, Sarita Suvira

Chulalongkorn University Theses and Dissertations (Chula ETD)

Prostate is one of the organs that can easily move or change during the treatment fractions. Adaptive radiotherapy can help to reduce the uncertainty of interfraction and decrease the side effects produced from the radiation given to the patients. The objective of this study was to provide evidence of the efficiency of adaptive radiotherapy for prostate cancer patients by investigating the dosimetric differences between the scheduled and adapted plans generated from Ethos. The treatment data of 100 fractions of prostate cancer patients who had previously been treated on Ethos daily adaptive radiotherapy were collected. The treatment data in each fraction …

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Accuracy In Classification Of Liver Lesion Ultrasound Using Artificial Intelligence, Sutthirak Tangruangkiat Jan 2022

Accuracy In Classification Of Liver Lesion Ultrasound Using Artificial Intelligence, Sutthirak Tangruangkiat

Chulalongkorn University Theses and Dissertations (Chula ETD)

B-mode ultrasound imaging is the standard method for hepatocellular carcinoma (HCC) screening. If a lesion has a unique appearance, a conventional detector can be applied. However, if the lesion shares its appearance with other lesion, a large training dataset is required, which may be unavailable. Therefore, a two-stage method is proposed. In the first stage, lesions are detected but not differentiated into any particular class. The detected lesions are then classified in the second stage using a conventional convolutional neural network (CNN). The aims of the dissertation are to design an artificial intelligent system model and to investigate the most …

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Accuracy Of Small-Field High Energy Photon Using Plastic Scintillation Detector In Heterogenous Media Compared With Model-Based Algorithm Calculation, Thanat Kaewsuksri Jan 2022

Accuracy Of Small-Field High Energy Photon Using Plastic Scintillation Detector In Heterogenous Media Compared With Model-Based Algorithm Calculation, Thanat Kaewsuksri

Chulalongkorn University Theses and Dissertations (Chula ETD)

Some radiotherapy techniques such as stereotactic body radiotherapy (SBRT) has the challenges in small field dosimetry in heterogenous media. This study aims at evaluating the accuracy of W2 plastic scintillation detector (PSD) compared with the calculation from algorithms for small-field high energy photon in heterogenous media. The characteristics of W2-PSD were studied. The percentage depth dose (PDD) of 6 FFF and 10 FFF with various field sizes ranging from 1x1 to 4x4 cm2 were measured in solid water phantom with low-density inhomogeneities slabs of air (Styrofoam) and lung (cork) and high-density inhomogeneity slab of aluminum. The characteristics of W2 plastic …

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Regulatory T Cell In Drug-Induced Severe Cutaneous Adverse Reactions (Scars) During Acute And Recovery Phase, Suparada Khanaruksombat Jan 2022

Regulatory T Cell In Drug-Induced Severe Cutaneous Adverse Reactions (Scars) During Acute And Recovery Phase, Suparada Khanaruksombat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a type of SCARs induced by various drugs. The autoimmune consequences were observed throughout the recovery phase ranging between 10 – 20 % of DRESS patients. The dynamics of regulatory T cells (Tregs) are thought to be responsible for the many symptoms of DRESS. They may be a key player in developing autoimmune sequelae in this syndrome. This study concentrated on the number and function of CD4+CD25+CD127-FoxP3+ Tregs in autoimmune development in DRESS patients. CD4+CD25+CD127-FoxP3+ Tregs and their immunophenotyping were characterized using peripheral blood mononuclear cells (PBMCs) from patients by Flow …

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Analysis Of Vocs From Exhaled Breath For The Diagnosis Of Hepatocellular Carcinoma, Thanikarn Suk-Aram Jan 2022

Analysis Of Vocs From Exhaled Breath For The Diagnosis Of Hepatocellular Carcinoma, Thanikarn Suk-Aram

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Volatile organic compounds (VOCs) were shown as promising biomarkers for hepatocellular carcinoma (HCC) diagnosis. We aimed to investigate the performance of VOCs for diagnosing early-stage HCC in patients at-risk for HCC. Methods: VOCs were identified in exhaled breath samples collected from 90 early-stage HCC patients, 90 cirrhotic patients, 91 HBV-infected patients, and 95 healthy volunteers using thermal desorption-gas chromatography/field-asymmetric ion mobility spectrometry. The VOC levels were compared between the four groups. An association between VOCs and HCC was determined using logistic regression analysis. Diagnostic performance of VOCs was estimated using the AUROC and compared to serum alpha-fetoprotein (AFP). Results: …

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The Association Of Genetic Variations In Pnpla3, Tm6sf2 And Hsd17b13 Genes In Non-Alcoholic Fatty Liver Disease Patients With And Without Hiv Infection., Varis Ruamviboonsuk Jan 2022

The Association Of Genetic Variations In Pnpla3, Tm6sf2 And Hsd17b13 Genes In Non-Alcoholic Fatty Liver Disease Patients With And Without Hiv Infection., Varis Ruamviboonsuk

Chulalongkorn University Theses and Dissertations (Chula ETD)

Non-alcoholic liver disease (NAFLD) has multiple risk factors, including genetic risk factors. Patients with certain genetic variants are more susceptible to the disease. People living with HIV (PLWH) have higher prevalence of NAFLD compared to those without HIV infection. But, the evidence on genetic factors in PLWH with NAFLD is limited. We aim to investigate whether carriers of PNPLA3 rs738409, TM6SF2 rs58542926, and HSD17B13 rs6834314 had association with the risk of NAFLD, and whether PLWH with NAFLD also had similar genetic risk factors as those with NAFLD alone. These SNPs were determined by using allelic discrimination in blood samples of …

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Comparing The Success Rate Of Pleurodesis With Thoracoscopic Talc Poudrage Combined With Indwelling Pleural Catheter Versus Thoracoscopic Talc Poudrage In Patient With Malignant Pleural Effusion, A Randomized, Non-Inferiority Clinical Trial, Jitanong Sootlek Jan 2022

Comparing The Success Rate Of Pleurodesis With Thoracoscopic Talc Poudrage Combined With Indwelling Pleural Catheter Versus Thoracoscopic Talc Poudrage In Patient With Malignant Pleural Effusion, A Randomized, Non-Inferiority Clinical Trial, Jitanong Sootlek

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Malignant pleural effusion (MPE) can cause dyspnea symptoms that greatly impact a patient's quality of life. Talc pleurodesis or indwelling pleural catheter (IPC) insertion are two treatment options that can prevent recurrent MPE, alleviate dyspnea, and improve quality of life. However, talc pleurodesis requires a lengthy hospital stay, while IPC insertion is associated with lower pleurodesis success rates. Due to limited hospital bed capacity, we have devised a practical approach to managing MPE by combining TTP and IPC. Objective: This study aims to evaluate the efficacy of combined Thoracoscopic talc poudrage (TTP) and IPC compared to TTP alone in …

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A Randomized Controlled Trial Comparing The Diagnostic Yield Of Using Rapid On-Site Cytology Evaluation (Rose) And Without Using Rose In Radial Probe Endobronchial Ultrasound (R-Ebus) Guided Sheath Transbronchial Lung Biopsy With Bronchial Brushing In Peripheral Pulmonary Lesions, Kulchamai Silathapanasakul Jan 2022

A Randomized Controlled Trial Comparing The Diagnostic Yield Of Using Rapid On-Site Cytology Evaluation (Rose) And Without Using Rose In Radial Probe Endobronchial Ultrasound (R-Ebus) Guided Sheath Transbronchial Lung Biopsy With Bronchial Brushing In Peripheral Pulmonary Lesions, Kulchamai Silathapanasakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

BACKGROUND: Radial Probe Endobronchial Ultrasonography (RP-EBUS) guided transbronchial biopsy with bronchial brushing is an effective way of tissue assessment for evaluating peripheral lung lesion combined with Rapid on-site Evaluation (ROSE). Our study aimed to evaluate the efficacy of ROSE add on RP-EBUS guided sheath transbronchial lung biopsy to improve the overall diagnostic yield. OBJECTIVES: The purpose of this study was to compare the diagnosis yield of peripheral lung lesions or nodules from the ROSE add on Radial Probe Endobronchial Ultrasonography (RP-EBUS) guided sheath transbronchial biopsy with bronchial brushing compared to the control group. METHODS: In this prospective randomized controlled trial …

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Comparison Of Extubation Success Between Prophylactic Helmet Niv And Facemask Niv In High Risk Postextubation Patients;A Randomized Controlled Trial, Napat Jirawat Jan 2022

Comparison Of Extubation Success Between Prophylactic Helmet Niv And Facemask Niv In High Risk Postextubation Patients;A Randomized Controlled Trial, Napat Jirawat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Post-extubation respiratory failure is a common complication in planned extubated patients, which increases mortality, particularly in high-risk patients. Noninvasive ventilation (NIV) with a facemask effectively prevents post-extubation respiratory failure, but helmet NIV use immediately after extubation is still unproven. Objective: To compare the success rates of extubation with prophylactic helmet NIV and facemask NIV in the first 48 hours in patients at high risk of developing post-extubation respiratory failure. Methods: The study was a single-center randomized controlled trial. The data were analyzed for 114 patients at high risk of extubation failure between June 2022 and June 2023. Patients were …

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Development Of An Artificial Intelligence Model For Prediction Of Dry Weight In Chronic Hemodialysis Patients And Assessment Of Its Accuracy Compared To Standard Bioelectrical Impedance Analysis, Nataphut Boonvisuth Jan 2022

Development Of An Artificial Intelligence Model For Prediction Of Dry Weight In Chronic Hemodialysis Patients And Assessment Of Its Accuracy Compared To Standard Bioelectrical Impedance Analysis, Nataphut Boonvisuth

Chulalongkorn University Theses and Dissertations (Chula ETD)

Proper determination of dry weight (DW) is crucial for achieving positive outcomes in hemodialysis (HD) patients. However, the traditional clinical assessment of DW (C-DW) is often inaccurate. Recently, bioimpedance spectroscopy (BIS) analysis using a Body Composition Monitor (BCM) device has emerged as a gold standard method for determining DW (BCM-DW). Despite its accuracy, the high cost of the BCM device limits its accessibility. To overcome this challenge, the current study proposes a machine learning (ML) model, which is a part of artificial intelligence (AI), to assess DW using available clinical and laboratory parameters. Objective: To develop an ML model for …

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Evaluation Of Tissue Adequacy In Patients With Malignant Intrathoracic Lymphadenopathy Undergoing Combined Endobronchial Ultrasound-Guided Miniforceps Biopsy (Ebus-Mfb) And Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (Ebus-Tbna) Compared To Ebus-Tbna Alone, Pipu Tavornshevin Jan 2022

Evaluation Of Tissue Adequacy In Patients With Malignant Intrathoracic Lymphadenopathy Undergoing Combined Endobronchial Ultrasound-Guided Miniforceps Biopsy (Ebus-Mfb) And Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (Ebus-Tbna) Compared To Ebus-Tbna Alone, Pipu Tavornshevin

Chulalongkorn University Theses and Dissertations (Chula ETD)

RATIONALE: EBUS-TBNA has become an effective way of tissue assessment for evaluating mediastinal lymph nodes. Identifying molecular mutations is a key to personalized management in malignant disease. The success of molecular analysis depends on adequate tissue specimens consisting of an absolute number of tumor cell counts and the neoplastic cell percentage (NCP) estimation. This study aimed to evaluate the efficacy of EBUS-MFB added on EBUS-TBNA to improve the tissue adequacy and the overall diagnostic yield. In this prospective study, patients with enlarged intrathoracic lymph nodes underwent EBUS-TBNA followed by EBUS-MFB. The tissue adequacy for molecular analysis required that the tissue …

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Genetic Analysis Of Focal Segmental Glomerulosclerosis In Thailand, Suramath Isaranuwatchai Jan 2022

Genetic Analysis Of Focal Segmental Glomerulosclerosis In Thailand, Suramath Isaranuwatchai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: The genetic variants spectra of focal segmental glomerulosclerosis (FSGS) vary among different populations. Here we described the clinical and genetic characteristics of biopsy-proven FSGS patients in Thailand. We also used special staining in renal biopsy tissue to describe protein expression related to the variants found by whole-exome sequencing (WES). Also, a functional study in cells was studied to investigate the etiologic evidence of the variants found by WES. Methods: Fifty-three unrelated FSGS patients without secondary causes were included in our study. Whole-exome sequencing (WES) was subsequently performed. Immunohistochemistry (IHC) staining method was used to characterize the morphology of renal …

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Anxiety And Social Experience Stressors Of Lgbt In Thailand, Bunatta Aritatpokin Jan 2022

Anxiety And Social Experience Stressors Of Lgbt In Thailand, Bunatta Aritatpokin

Chulalongkorn University Theses and Dissertations (Chula ETD)

The enhancement of the quality of life, according to the Sustainable Development Goals set by the United Nations (UN-SDG), places importance in equality for all groups of people, in all aspects. In this regard, although the Thailand sphere has been praised for its efforts to demonstrate its progressiveness regarding equality for groups who are more vulnerable to stressors, in practice, it is still quite lacking which could cause issues with mental health, such as anxiety and other stressors. This descriptive cross sectional quantitative research study explores the anxiety and social experience stressors of once such group - those of different …

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D-Lactic Acid Fermentation Platform From Oil Palm Trunk Sap By Sporolactobacillus Terrae Sbt-1, Naphatsawan Sukaiem Jan 2022

D-Lactic Acid Fermentation Platform From Oil Palm Trunk Sap By Sporolactobacillus Terrae Sbt-1, Naphatsawan Sukaiem

Chulalongkorn University Theses and Dissertations (Chula ETD)

Lactic acid is an organic acid that contains two enantiomers, L- and D-lactic acid, and is considered the most potential monomer for many industrial products. Lactic acid has versatile applications in the pharmaceutical, food, textile, chemical, and leather industries moreover in poly-lactic acid (PLA) manufacturing. While L-lactic acid is well known in many commercial products and studies, only a few studies on D-lactic acid were found. Lactic acid can be produced either by microbial fermentation or chemical synthesis. Approximately 90 percent of the total lactic acid produced worldwide is via microbial fermentation which provides an optically pure L- or D-lactic …

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