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Articles 163711 - 163740 of 167964
Full-Text Articles in Entire DC Network
Analysis Of Expression Patterns Of Brassinosteroid-Responsive Genes In Arabidopsis Root Using Single-Cell Rna Sequencing Datasets, Thanaporn Wongkham
Analysis Of Expression Patterns Of Brassinosteroid-Responsive Genes In Arabidopsis Root Using Single-Cell Rna Sequencing Datasets, Thanaporn Wongkham
Chulalongkorn University Theses and Dissertations (Chula ETD)
Brassinosteroid (BR) plays a complex role in root growth and development by regulating the expression of downstream target genes through the BR signaling pathway. In this scRNA-seq study of Arabidopsis roots, tissue- and developmental-specific roles of BR were identified. Atrichoblast, an epidermal cell that develops into a non-hair cell, displayed the highest enrichment of BR-induced genes in the elongation and maturation zones among all cell types. Trajectory analysis revealed distinct expression patterns of BR biosynthesis and signaling genes between atrichoblasts and trichoblasts. Atrichoblasts exhibited higher expression levels of BR biosynthesis genes (DET2 and ROT3) and BR signaling genes (BRI1 and …
Whole Genome Sequencing, De Novo Assembly, And Comparative Analysis Of Varanus Salvator And Megaustenia Siamensis, Wanna Chetruengchai
Whole Genome Sequencing, De Novo Assembly, And Comparative Analysis Of Varanus Salvator And Megaustenia Siamensis, Wanna Chetruengchai
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Understanding the animal genome structure and function is pivotal for expanding our current knowledge of evolution, biodiversity, cosmeceutical and medical applications. Each species has a unique characteristic feature. Varanus salvator is a reptile (vertebrate) prevalent in Thailand. It has evolved over millions of years to adapt and survive in urban environments, polluted canals, and garbage dumps. It still survives without noticeable effects. Megaustenia siamensis, an invertebrate, is famous for its ability to produce biological adhesive substances enabling it to stick to trees’ leaves even in heavy rain. However, there is very little genomics or transcriptomics data for V. salvator …
The Role Of B1 Methylation, Physiologic Replication Independent Endogenous Dna Double Strand Breaks (Phy-Rind-Edsb) And Laminin 511 E8 Proteins In Rat Second Degree Burn Wound Healing, Jiraroch Meevassana
The Role Of B1 Methylation, Physiologic Replication Independent Endogenous Dna Double Strand Breaks (Phy-Rind-Edsb) And Laminin 511 E8 Proteins In Rat Second Degree Burn Wound Healing, Jiraroch Meevassana
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: DNA methylation via short interspersed nuclear element (SINE) small interfering (si)RNA prevents DNA damage and promotes cell proliferation. Furthermore, laminin α5 β1 γ1(LM511) is an extracellular structural protein that can support epithelial cell adhesion and migration. Box A of high-mobility group box 1 protein (Box A of HMGB1) is a common nuclear protein in eukaryotic cells that can reduce DNA damage response toward burn injury. Objective: To investigate whether treatment of burn wounds using B1 siRNA, Box A of HMGB1 and LM511-E8 fragment improved wound closure in a rat second-degree burn wound model. Methods: I performed a cross-sectional analytical …
Senescent White Blood Cells In Colorectal Carcinoma Patients, Khin Aye Thin
Senescent White Blood Cells In Colorectal Carcinoma Patients, Khin Aye Thin
Chulalongkorn University Theses and Dissertations (Chula ETD)
Colorectal cancer (CRC) and ageing can contribute to changes in immune cells including immuno-senescence. The objectives of the study were to determine if the senescence marker (p16INK4A) was expressed more at higher levels in peripheral white blood cells in CRC compared to age-matched healthy controls. Another aim was to determine the phenotypic changes of T cells, NK cells and monocytes during ageing and CRC in case-control studies. Cases were patients with CRC and controls were matched with cases based on age. Peripheral immune cells were analysed for p16INK4A using immunofluorescence and immunophenotypes were determined with flow cytometry. Correlation studies with …
The T Cell Senescence In Breast Cancer, Sikrit Denariyakoon
The T Cell Senescence In Breast Cancer, Sikrit Denariyakoon
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: The cancer-immune cell crosstalk is a common immune-evasion mechanism of cancer. This crosstalk can result in epigenetic changes in immune phenotypes to accelerate tumor growth and metastasis. Senescent T lymphocytes are formed during T cell differentiation, and are recently described as one of the dysfunctional T cells in cancer. In breast cancer, estrogen does not only regulate normal physiology in females, but is also involved in cancer development and cancer treatment. It may also attenuate senescent phenotypes, and increase DNA damage in several cell-lines. This thesis therefore examined for the presence of senescent T lymphocytes in breast cancer patients, …
Screening Of Clostridium Sp. For Biohydrogen Production From Synthetic Wastewater, Chonticha Srimawong
Screening Of Clostridium Sp. For Biohydrogen Production From Synthetic Wastewater, Chonticha Srimawong
Chulalongkorn University Theses and Dissertations (Chula ETD)
In this work, bacteria that can produce endospores were isolated from natural sources and industrial wastes, including mangrove forests, hot springs, and coconut factories. The bacterial isolates were identified as Clostridium spp. and Panibacillus spp. based on 16S RNA gene. When comparing the H2 produced by batch fermentation, two of the isolates with the best H2 production were selected for further study, namely CUEA01 and CUEA03. After genomics analysis, it was discovered that CUEA01 is a novel species named C. hydrogenum, and CUEA03 is C. felsineum. Both are capable of growing and producing H2 in alkaline conditions. The genomics data …
Screening Of Clostridium Sp. For Butanol Production From Sato (Thai Rice Wine) Factory Wastewater, Julalak Buranaprasopchai
Screening Of Clostridium Sp. For Butanol Production From Sato (Thai Rice Wine) Factory Wastewater, Julalak Buranaprasopchai
Chulalongkorn University Theses and Dissertations (Chula ETD)
The production of Sato, a Thai traditional beverage, yields Sato wastewater (STW), which contains residual rice constituents with high chemical and biological oxygen demands and so forms an environmental problem. In addition, STW often smells rotten from the formation of hydrogen sulfide. To solve this problem, the composition of STW was analyzed for its physiological and chemical characteristics to evaluate its potential as a substrate for ABE fermentation using Clostridium spp., which has never been reported for use in acetone-butanol-ethanol (ABE) fermentation before. Solvent-producing Clostridium isolates were obtained from environmental sources in Thailand, and that producing the highest butanol level …
Identification And Application In Plant Of Plant Growth-Promoting Endophytic Bacteria, Kanchana Sitlaothaworn
Identification And Application In Plant Of Plant Growth-Promoting Endophytic Bacteria, Kanchana Sitlaothaworn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Seventy-eight endophytic bacteria isolated from 15 plant samples in Thailand including 50 isolates from sugarcane root samples obtained from 6 Provinces and 28 isolates from stems and leaves of healthy plants in Kanchanaburi Province, were identified and evaluated for plant growth promoting capability using rice as a plant model. They were identified as Gluconacetobacter (37 isolates), Pantoea (14 isolates), Burkholderia (2 isolates), Pseudomonas (4 isolates), Priestia (4 isolates), Enterobacter (2 isolates), Acinetobacter (2 isolates), Novosphingobium (2 isolates), Curtobacterium (2 isolates), and each of Nguyenibacter, Aureimonas, Bacillus, Peribacillus, Sphingobium, Staphylococcus, Brevibacillus, Aneurinibacillus, and Pseudarthrobacter based on their phenotypic characteristics and 16S …
Anti-Pathogenic Yeast Malassezia Globosa Activity By Propolis Of Stingless Bee Geniotrigona Thoracica, Kawisara Konsila
Anti-Pathogenic Yeast Malassezia Globosa Activity By Propolis Of Stingless Bee Geniotrigona Thoracica, Kawisara Konsila
Chulalongkorn University Theses and Dissertations (Chula ETD)
Malassezia globosa is a lipophilic pathogen which relates to various chronic skin diseases. Azole drugs are main available treatments, but they have been reported with many side effects and microbial drug resistance. Therefore, the alternative medications should be developed. As the antimicrobial activity of propolis is outstanding, this study aims to investigate the potential of propolis from stingless bee, Geniotrigona thoracica against the pathogenic yeast. The extraction and characterization of the propolis components were done after the obtained extracts were evaluated for anti-M. globosa growth by using agar well diffusion assay and broth microdilution assay. Moreover, Inhibitory Concentration values at …
Antiproliferative Agents From Mushroom Phellinus Sp., Kulrut Pichayaphinyo
Antiproliferative Agents From Mushroom Phellinus Sp., Kulrut Pichayaphinyo
Chulalongkorn University Theses and Dissertations (Chula ETD)
In this study, Phellinus powdered (600 g) was extracted with methanol and DI water. The methanolic crude extract of the mushroom was partitioned with hexane, dichloromethane, ethyl acetate and methanol respectively. All crude extracts were evaluated antiproliferative activity against lung cancer (A549) and neuroblastoma (SH-SY5Y) cell lines by MTT assay. It was found that the dichloromethane extract (CDE) exhibited the strongest antiproliferative activity with half maximal inhibitory concentration (IC50) values of 132.4 and 106.87 µg/mL against human lung cancer and neuroblastoma cell lines, respectively. The ethyl acetate extract (CEE) exhibited moderate antiproliferative activity with IC50 values of 138.64 and >250 …
Effect Of Genipin Cross-Linking On Properties Of Chitosan Based Bio-Composite Film, Patthrare Inthamat
Effect Of Genipin Cross-Linking On Properties Of Chitosan Based Bio-Composite Film, Patthrare Inthamat
Chulalongkorn University Theses and Dissertations (Chula ETD)
Active packaging from chitosan film incorporated with astaxanthin is limited commercial application in the food industry due to its high moisture permeability and poor tensile strength. To overcome these problems, crosslinking of the film with genipin and heat curing to improve film properties were proposed. Firstly, the effects of genipin concentration on the physical, moisture barrier and mechanical properties of chitosan films incorporated with astaxanthin were investigated. Chitosan film was prepared by mixing chitosan in 2% (w/w) lactic acid. The chitosan was incorporated with astaxanthin at 0 and 1% (w/w of chitosan) (marked as CS and CA or CSA) and …
Nft-Based Authentic Product Verification And Trading Platform, Natchapol Thongruang
Nft-Based Authentic Product Verification And Trading Platform, Natchapol Thongruang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Counterfeit product has been a major problem to the economy for a while. The effect seems to be larger when it comes to the luxury product segment. When the consumers were unsure if the product that they are buying is genuine or not and its cost is very high, then the severity will become even greater. Among the countless number of attempts to fix this solution, utilizing blockchain technology is one of the most popular approaches for present days. In anti-counterfeit domain, associating an NFT token to a physical product is the most common approach. It allows us to unlock …
Investigate The Possibility Of Using Smart Contracts And Digital Signatures To Create A Legally Binding Contract, And To Create A Prototype Opensource Web Application As A Proof Of Concept, Yosnai Chanatrutipan
Investigate The Possibility Of Using Smart Contracts And Digital Signatures To Create A Legally Binding Contract, And To Create A Prototype Opensource Web Application As A Proof Of Concept, Yosnai Chanatrutipan
Chulalongkorn University Theses and Dissertations (Chula ETD)
We investigated the possibility of using blockchain to create a legally binding contract. According to our study, blockchain can be used to authenticate the identities of the involved parties, to provide a cryptographically generated electronic signature used to sign a contract, and to automate and enforce the term of an agreement. The authentication and the signing are done using a blockchain-based self-sovereign identity framework called a decentralized identity and verifiable credentials. The term can be enforced by using a smart contract, a program that runs on the blockchain. Some contracts terms are too complex to be translated into a smart …
Estimating Stock Price Based On Information From Financial Statement Using Machine Learning Approach, Thitikun Kunathananon
Estimating Stock Price Based On Information From Financial Statement Using Machine Learning Approach, Thitikun Kunathananon
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study introduces a new tool for stock market investors and institutions constructed from Long Short-Term Memory (LSTM) for predicting stock prices. By effectively analyzing financial statements and stock market data, LSTM provides a fast, unbiased, low-cost solution for stock price prediction, intending to increase profits for investors and reduce losses. The study results indicate that LSTM can maintain effectively captures complex relationships in the data and predicts stock prices. This research highlights the potential of LSTM as a valuable and innovative tool for investors and institutions in the stock market.
Combining Technical Analysis And Deep Learning Models For Stock Market Trading, Phurinut Pholsri
Combining Technical Analysis And Deep Learning Models For Stock Market Trading, Phurinut Pholsri
Chulalongkorn University Theses and Dissertations (Chula ETD)
The issuance of stocks constitutes a means by which ownership in a company is represented, and its distribution may vary depending on whether the company is limited or public. The stock market offers the potential for high returns, thereby serving as an attractive avenue for investment. Against this backdrop, the objective of this study is to develop a predictive model for stock prices that can facilitate profitable trading outcomes. To achieve this aim, the study focuses on intraday and hourly trading and utilizes a hybrid model that integrates Bidirectional Long Short-Term Memory (BiLSTM) and Convolutional Neural Network (CNN) architectures, along …
Real-Time Object Detection For Screening Cannabis Seed Gender, Prachya Boonsri
Real-Time Object Detection For Screening Cannabis Seed Gender, Prachya Boonsri
Chulalongkorn University Theses and Dissertations (Chula ETD)
Perception and understanding of cannabis are more expansive than they formerly were. Almost all growers are primarily interested in getting harvests of big flower buds from cannabis female plants since THC, CBD and other cannabinoids are found in female flowers and valuable for medical and industrial market segments. Selecting only female seeds to cultivate is thus an important step to produce THC, CBD profitably. Unfortunately, outdoor cultivation in Thailand traditionally grows regular cannabis seeds that grow up of mixed male and female plants. The male plants will be later spot and eliminated during the pre-flowering stage. This incurs the higher …
A Comparative Study On Out Of Scope Detection For Chest X-Ray Images, Nuttapol Kamolkunasiri
A Comparative Study On Out Of Scope Detection For Chest X-Ray Images, Nuttapol Kamolkunasiri
Chulalongkorn University Theses and Dissertations (Chula ETD)
Image classification models in actual applications may receive input outside the intended data distribution. For crucial applications such as clinical decision-making, it is critical that a model can recognize and describe such out-of-distribution (OOD) inputs. The objective of this study is to investigate the efficacy of several approaches for OOD identification in medical images. We examine three classes of OOD detection methods (Classification models, Confidence-based models, and Generative models) on the data of X-ray images. We found that simple classification methods and HealthyGAN perform the best overall. However, HealthyGAN cannot generalize to unseen scenarios, while classification models still retain some …
Xgboost For Prediction Of Ethereum Short-Term Returns Based On Technical Factor, Wipawee Nayam
Xgboost For Prediction Of Ethereum Short-Term Returns Based On Technical Factor, Wipawee Nayam
Chulalongkorn University Theses and Dissertations (Chula ETD)
Unlike traditional currencies that rely on centralized such as banks or governments, cryptocurrencies today have become popular due to its decentralized transactions. Decentralization takes advantage of no requirement for intermediaries, thus reducing transaction fees and processing time. However, investing in cryptocurrencies incurs risks and uncertainties due to price volatility and rapid changes. The fact that prediction of asset prices is complex due to the influence of multiple factors on price movements. This paper studied the technical factor to analyze the short-term returns of Ethereum in the periods of 1-10 days. The historical data containing Ethereum closing price are collected from …
Class-Level And Token-Level Approaches For Test Impact Analysis, Alon Basin
Class-Level And Token-Level Approaches For Test Impact Analysis, Alon Basin
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objective of the thesis is to examine the efficacy of test impact analysis in a setting of continuous testing, where automated test cases are routinely run to guarantee the integration of high-quality codes. While continuous testing can enhance code quality and minimize maintenance workload, it also leads to a notable rise in overhead for test execution. In our study on test impact analysis, we developed a novel static class level technique that utilizes JavaParser to create a dependency graph between test cases and source code classes based on abstract syntax trees. We applied this technique to seven Java systems …
Y-X-Y Encoding For Identifying Types Of Sentence Similarity, Thanaporn Jinnovart
Y-X-Y Encoding For Identifying Types Of Sentence Similarity, Thanaporn Jinnovart
Chulalongkorn University Theses and Dissertations (Chula ETD)
The task of finding semantic similarity of any two arbitrary sentences consists of two main steps, which are encoding sentences to produce feature vectors of equal length and measuring the similarity, respectively. The quality of an encoding technique can determine the degree of success a model can achieve in measuring the similarity. This is because a good representation is subjected to how finely established the spectrum of similarities is. The clearer the definition of similarity is, the better the representations can be constructed. This, in turn, helps distinguish between types of sentences. Generally, all existing methods for measuring similarity were …
Effects Of Lipids And Surfactants On The Characteristics Of Asiatic Acid-Loaded Solid Lipid Microparticles, Jatuporn Witarat
Effects Of Lipids And Surfactants On The Characteristics Of Asiatic Acid-Loaded Solid Lipid Microparticles, Jatuporn Witarat
Chulalongkorn University Theses and Dissertations (Chula ETD)
The objective of this study was to evaluate the effects of solid lipids: beeswax and cetyl alcohol, and surfactants: Tween 80®, soybean lecithin and poloxamer 188 on the characteristics of solid lipid microparticles containing asiatic acid (AASLM). The AASLM were prepared from 10% or 15% of beeswax or cetyl alcohol together with 3% of surfactant F1-F12) by melt dispersion cum freeze-drying technique to obtain a solid dosage form. The physicochemical characteristics of the AASLM powders, including appearance, surface morphology, particle size, %labeled amount of asiatic acid (AA) and %entrapment efficiency (EE) were evaluated. The results revealed that AASLM prepared from …
Formation Control Of Mobile Robot Swarm In Search Operation, Chanun Asavasirikulkij
Formation Control Of Mobile Robot Swarm In Search Operation, Chanun Asavasirikulkij
Chulalongkorn University Theses and Dissertations (Chula ETD)
The use of swarm mobile robots has emerged as a promising approach to enhance search efficiency in various applications. This thesis focuses on proposing an effective design and fabrication methodology for a swarm mobile robot system based on the Robot Operating System (ROS) framework. Additionally, a novel network architecture is presented to improve communication efficiency among the robots. The primary objective of this research is to investigate the formation control of swarm mobile robots and their superior ability in search operations. Through extensive experiments and quantitative analysis, the performance of the proposed formation control strategy is evaluated in terms of …
Factors Associated With And Impacting Coming Out For Sexual Identity Minorities In The United States, Matthew Robert Kusen
Factors Associated With And Impacting Coming Out For Sexual Identity Minorities In The United States, Matthew Robert Kusen
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research aims to explore socio-demographic and other individual factors potentially associated with the probability of coming out as Lesbian, Gay, Bisexual, Queer and other sexual identities (LGBQ+) to friends and family and the probability of being outed as LGBQ+ to family members before being ready or without consent in the United States (UCS). This research analyzed quantitative data from the 2016-17 Generations Study, a nationally representative population-based survey collecting information from LGBQ+ persons residing across the US (N=1,416), and employed both descriptive and multivariate analyses, using the logistic regression model and the Cox proportional hazard model. Several factors were …
The Socio-Economic Determinants Of The Life Satisfaction Of Older Persons In Myanmar In 2019, Myo Thandar
The Socio-Economic Determinants Of The Life Satisfaction Of Older Persons In Myanmar In 2019, Myo Thandar
Chulalongkorn University Theses and Dissertations (Chula ETD)
Myanmar has undergone significant demographic changes, and the share of the older population has increased. Myanmar is facing the challenge in providing social protections to the increasing number of older people, like many other rapidly-ageing societies. As people get older, their physical health and functional ability deteriorate and, as a result, their life satisfaction also declines in most cases. Therefore, it is crucial to consider factors that contribute to the perception of life satisfaction among this venerable cohort. This study explored the determinants of life satisfaction of older persons and investigated whether there are gender differences in the determinants of …
Preventive Health Care And Health Care Services Utilization Of Vietnamese Older Persons : Results From National Household Living Standards Survey 2018, Thao Nguyen Thi
Preventive Health Care And Health Care Services Utilization Of Vietnamese Older Persons : Results From National Household Living Standards Survey 2018, Thao Nguyen Thi
Chulalongkorn University Theses and Dissertations (Chula ETD)
As many countries are aging rapidly, improving older persons’ health and reducing the burden of disease are important goals. However, many developing countries still lack effective policies in the areas of preventive health care and health services utilization of older persons. This study aims: (1) to determine the health status by severe injury report and health care service needs of Vietnamese older persons, (2) to investigate the factors associated with the use of health check-up services of Vietnamese older persons, and (3) to investigate the differences in health care services utilization between different medical needs of Vietnamese older persons. Using …
Learning Model For Improving Quality Of Life Of Cambodian Migrant Workers Working And Living In Thailand, Chanrasmey Lay
Learning Model For Improving Quality Of Life Of Cambodian Migrant Workers Working And Living In Thailand, Chanrasmey Lay
Chulalongkorn University Theses and Dissertations (Chula ETD)
The purpose of this research study were 1) to study the current living situation of Cambodian migrant workers working and living in Thailand, 2) to study how all stakeholders and those Cambodian migrant workers could work together to improve the quality of life of those Cambodian migrant workers living and working in Thailand, and 3) to propose a learning model for improving the quality of life of Cambodian migrant workers working and living in Thailand. The data was collected quantitatively and qualitatively from the survey and in-depth interview. The sample for the survey was 100 Cambodian migrant workers who were …
Investigation Of Mass Wasting In The Vicinity Of Khao Kho, Central Thailand Using Time – Series Insar Technique, Nuttavit Kumvijairat
Investigation Of Mass Wasting In The Vicinity Of Khao Kho, Central Thailand Using Time – Series Insar Technique, Nuttavit Kumvijairat
Chulalongkorn University Theses and Dissertations (Chula ETD)
The application of time-series InSAR has been employed for investigation of mass wasting in the Khao Kho and Phetchabun mountain range. The objective of this study is to Investigation of mass wasting by SAR data between 2015 to 2018 and classification of mass wasting by displacement rate millimeter/year. This study using active remote sensing data, which is Synthetic Aperture Radar (SAR) satellite imagery from Sentinel-1A and Sentinel-1B satellites. Result from PSInSAR analysis yielded a total of 7,354 PS points for ascending orbit, and 8,984 PS point for descending orbit. The average ground displacement rate result from ascending orbit is 65.19 …
An Analysis On Trends Of Research Topics In Civic Education Using Dynamic Topic Model, Poon Thongsai
An Analysis On Trends Of Research Topics In Civic Education Using Dynamic Topic Model, Poon Thongsai
Chulalongkorn University Theses and Dissertations (Chula ETD)
The aim of this thesis is to study the trend of civic and citizenship education research from 2000 to 2020 and the influence the regional background of researches has on the research discussion. Relevant data is collected from ERIC and SCOPUS database. This includes abstracts, published year, regional background of researchers, and author h-index. The keywords used are “civic education” or “citizenship education” or “civics”. There are 4917 papers extracted in total. Upon doing further preparation, 4854 articles are prepared for analysis. We apply Structural Topic model (STM) technique to the abstracts with covariates including the published year and the …
Academic Management Strategies Of Secondary Schools Based On The Concept Of Intercultural Competence, Muanfan Korattana
Academic Management Strategies Of Secondary Schools Based On The Concept Of Intercultural Competence, Muanfan Korattana
Chulalongkorn University Theses and Dissertations (Chula ETD)
The research objectives were to 1) study conceptual frameworks of academic management of secondary schools and intercultural competence, 2) study students’ intercultural competence levels, 3) analyze strengths, weaknesses, opportunities, and threats (SWOT) of academic management of secondary schools based on the concept of intercultural competence, and 4) develop academic management strategies based on the concept of intercultural competence, using a multiphase mixed-methods design methodology. The study population was 19 schools, with 307 respondents, including school administrators, head teachers, and teachers. Research instruments included questionnaires and evaluation forms. Data analysis included frequencies, percentages, arithmetic mean, standard deviations, modified priority needs index …
Academic Management Strategies Of Secondary Schools In Cambodia Based On The Concept Of Innovation Leadership Skills, Nguon Siek
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study aimed to 1) study conceptual frameworks of academic management of secondary schools in Cambodia and innovation leadership skills, 2) study students’ innovation leadership skills levels, 3) analyze strengths, weaknesses, opportunities, and threats of academic management based on the concept of innovation leadership skills, and 4) develop academic management strategies based on the concept of innovation leadership skills. Multiphase mixed-methods design were employed. Samples included 2,662 students as respondents in Phase II and 94 public secondary schools in Phase III. Respondents included school administrators and teachers. Research instruments included evaluation forms and questionnaires. Data were analyzed using frequency, percentage, …