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Endogenous Retroviral Proteins As Potential Drug Targets For Merlin-Deficient Tumours, Bora Agit

Peninsula Medical School Theses

Merlin is a tumour suppressor, and its loss is the major cause of a hereditary disease Neurofibromatosis type 2 (NF2) characterised by the development of multiple tumours of the nervous system such as schwannomas, meningiomas and ependymomas. Current surgical treatments and radiotherapy for this group of tumours are not fully effective and there is an urgent need for new therapeutic options. Human endogenous retroviruses (HERVs) are retroviruses that have been incorporated into the human genome during evolution, now comprising 5% of it. The majority of HERVs are defective except for a few groups, including type K (HERV-K) which kept full-intact …

Decrease In Returning Pediatric Amblyopia Patients And Potential Impact On Visual Outcomes, Earnest S. Kim, Leah G. Reznick, Kellyn N. Bellsmith, Tosha Zaback, Abigail Lucero, Christa J. Prentiss, Michelle Hribar

Faculty Publications - Psychology Department

Prompt treatment of amblyopia, the leading cause of vision loss in children, is imperative for preserving vision. One of the primary barriers to successful amblyopia treatment is failure to follow up. Previous research has identified socioeconomic status as a significant risk factor for predicting whether patients are lost to follow up after the initial visit (23% of patients). In this retrospective study, we investigate patient follow up for their prescribed appointments and the potential impact on visual outcomes.

Attitudes Toward And Difficulties With Childhood Amblyopia Patching Treatment, Christa J. Prentiss, Michelle Hribar, Kellyn N. Bellsmith, Tosha Zaback, Earnest S. Kim, Abigail Lucero, Leah G. Reznick

Faculty Publications - Psychology Department

Amblyopia is the leading cause of visual loss in children and young adults, affecting up to 5% of people of all ages. Patching and atropine eyedrops successfully treat this condition. However, adherence to treatment is often poor. Current literature has identified factors impacting compliance, but less is known about successful interventions to improve adherence. This study’s purpose is to identify parent attitudes towards amblyopia treatment and barriers to treatment compliance in order to inform future provider and multidisciplinary approaches to improve adherence.

Marjon Connect Conversation Partner Scheme: Fourteen Years, Three Thousand Conversations And Quite A Few Cups Of Tea, Esther Pettit

School of Health Professions

No abstract provided.

To Fly Or Not To Fly? Comparing Vantage Point And Uncrewed Aerial Vehicle Surveys For Assessments Of Seabird Abundance And Fine-Scale Distribution, Melissa M. Costagliola-Ray, Lilian Lieber, W. Alex M. Nimmo-Smith, Elizabeth A. Masden, Paul Caplat, Jared Wilson, Nina J. O'Hanlon

School of Biological and Marine Sciences

Marine renewable energy developments (e.g. offshore wind, wave, and tidal) are an increasing feature within the marine environment. It is therefore important to understand the potential impacts of such developments on seabirds that use these environments. Land-based vantage point (VP) surveys are widely used to collect data for environmental impact assessments (EIAs) within tidal stream energy sites. However, tidal stream environments are highly dynamic and present challenges when conducting VP surveys, for example there can be varying detectability of seabirds due to near-surface turbulence. In recent years, there has been increasing interest in the use of uncrewed aerial vehicles (UAVs) …

Functional Standing Frame Programme Early After Severe Sub-Acute Stroke (Spires): A Randomised Controlled Feasibility Trial, Angela Logan, Jennifer Freeman, Bridie Kent, Jill Pooler, Siobhan Creanor, Doyo Enki, Jane Vickery, Andrew Barton, Jonathan Marsden

School of Health Professions

Abstract Background Early mobilisation (> 24 h post-stroke) is recommended for people with stroke. However, there is a paucity of evidence about how to implement early mobilisation for people who have had a severe stroke. Prolonged standing and task-specific training (sit-to-stand repetitions) have separately been evaluated in the literature; however, these functionally linked tasks have not been evaluated in combination for people with severe sub-acute stroke. Methods The objective was to determine the feasibility of conducting a randomised controlled trial (RCT) of a functional standing frame programme compared with usual physiotherapy for people with severe sub-acute stroke. An assessor-blinded feasibility …

Prevalence And Incidence Of Mental Health Issues Amongst Adults With Diabetes At Risk Of Foot Complications In The European Union: A Systematic Review Protocol, Jennifer Kate Williams, Richard Collings, Bridie Kent, Joanne Paton

School of Health Professions

No abstract provided.

Microplastics In The School Classrooms Of Shiraz, Iran, Sajjad Abbasi, Andrew Turner, Reza Sharifi, Mohammad Javad Nematollahi, Mehrzad Keshavarzifard, Tahereh Moghtaderi

School of Geography, Earth and Environmental Sciences

Microplastics (MPs) are a pervasive and ubiquitous environmental contaminant. However, very little information exists on the quantities or characteristics of MPs in the indoor setting. In the present study, MPs have been isolated from settled classroom dust samples collected from 50 schools in the city of Shiraz, Iran. Concentrations of MPs on a number basis ranged from about 80 to over 56,000 MP per g of dry dust and there was an increase in concentration towards the centre and southeast of the city. The geographical distribution is attributed to a larger population and student density, higher traffic loading and greater …

Messages In A Time Of Crisis Graphic Communication Design A Change Of Tack?, V Squire

School of Art, Design and Architecture

No abstract provided.

Highest Densities Of Mountain Hares ( Lepus Timidus ) Associated With Ecologically Restored Bog But Not Grouse Moorland Management, Carlos P.E. Bedson, Philip M. Wheeler, Neil Reid, Wilson Edwin Harris, David Mallon, Simon Caporn, Richard Preziosi

School of Biological and Marine Sciences

No abstract provided.

Dentistry Where There Is No Dentist: A Retrospective Analysis Of Urgent Dental Care Reported Through The British Antarctic Survey Medical Unit (Basmu), 2015 – 2020, Ewen Mccoll, Robert Witton, Tanya Lommerse, Matt Warner

Peninsula Dental School

AIM: To evaluate the nature of dental related morbidity in British Antarctic Survey (BAS) deployed personnel, and to compare the findings to those in other deployed population groups. Additional aims include outlining the evidence-based approach to further developing a training programme for non-dentists, to manage dental emergencies. METHODS: A retrospective analysis of dental morbidity between 2015 - 2020 reported through the British Antarctic Survey Medical Unit (BASMU) database of dental reported morbidity recorded by deployed medical officers. RESULTS: Analysis and comparison of dental morbidity in deployed personnel to austere environments revealed similarity, in that relatively minor conditions led to the …

Portraits Of Bankruptcy Filers, Pamela Foohey, Robert M. Lawless, Deborah Thorne

Scholarly Works

One in ten adult Americans have turned to the consumer bankruptcy system for help. For the past almost forty years, the only systematic data collection about the people who file bankruptcy comes from the Consumer Bankruptcy Project (CBP), for which we serve as co-principal investigators. In this Article, we use CBP data from 2013 to 2019 to describe who is using the bankruptcy system, providing the first comprehensive overview of bankruptcy filers in thirty years. We use principal component analysis to leverage these data to identify distinct groups of people who file bankruptcy. This technique allows us to situate the …

Steering Loan Modifications Post-Pandemic, Pamela Foohey, Dalie Jimenez, Christopher K. Odinet

Scholarly Works

As part of federal and state relief programs created during the COVID-19 pandemic, many American households received pauses on their largest debts, particularly on mortgages and student loans. Others may have come to agreements with their lenders, likewise pausing or altering payment on other debts, such as auto loans and credit cards. This relief allowed households to allocate their savings and income to necessary expenses, like groceries, utilities, and medicine. But forbearance does not equal forgiveness. At the end of the various relief periods and moratoria, people will have to resume paying all their debts, the amounts of which may …

Credit Scoring Duality, Pamela Foohey, Sara Sternberg Greene

Scholarly Works

Credit scoring is central to people’s financial growth and prosperity or financial decline and stagnation. People with a good credit score and accompanying credit report can buy opportunities to advance economically. The benefits they reap from their attractiveness to lenders and employers helps feed their future success. In contrast, people with a fair or poor credit score become stuck in cycle of high interest rates and costly loan terms, large required down payments, and denied applications for rentals, cell phone plans, and employment. Employers, service providers, lenders, and alternative financial service providers have begun to use alternative credit scoring models, …

Isaac Newton As A Prophetic Interpreter, Kenneth Jørgensen

Dissertations

Throughout his life, Sir Isaac Newton was deeply dedicated to the science of decoding biblical apocalyptic writings. To understand and appreciate Newton's prophetic scheme, it will be advantagous to have a certain grasp of what sources and ideas might have influenced him. No comprehensive study before this one has helped us see Newton from that perspective. A survey of the development of canonical apocalyptic hermeneutic and interpretation, beginning before the time of Christ and ending with Newton, shows that four distinct systems of hermeneutics had developed by that time. Historicism was the earliest and the preferred system among Protestants until …

An Analysis Of The Use Of The Writings Of Ellen G. White In The Views Of Herbert Douglass And Woodrow Whidden On The Human Nature Of Christ, Cyril Marshall

Dissertations

The human nature of Christ is one of the more controverted topics within Seventh-day Adventism. This dissertation analyzes the works of two influential writers on this topic—Herbert Douglass and Woodrow Whidden—comparing their use of Ellen White's writings on the human nature of Christ. The purpose of this study is to discover the hermeneutical principles they each employed in interpreting Ellen White's writing on Christ's humanity. The research utilizes primary source materials from all three authors, as well as secondary source materials, including books, journals, magazines, papers, and course notes.

The author concludes that there are statements in the writings of …

A Study Of Teacher Burnout In Private Seventh-Day Adventist And Public Schools In Trinidad/Tobago And Michigan, Usa, Carla Copeland-Joseph

Dissertations

Problem

Burnout as described by Maslach and Leiter (2007) is a syndrome involving psychological processes that result from Emotional Exhaustion, Depersonalization and diminished Personal Accomplishment in the workplace. It is represented as a stressful experience that is rooted in a person’s own interpretation of social relationships and needs. The aim of this study was to investigate teacher burnout and its interactions with individual factors (Gender, Years of Experience, Emotional Intelligence, Nationality), organizational factors (School Type, School Culture), and transactional factors (Technology Use, Teacher Self-Efficacy) for teachers in Trinidad and Tobago and the state of Michigan in the United States. The …

Increasing Cancer Survivorship Knowledge Through Individualized Cancer Survivorship Packets, Ashley Atkins

Doctor of Nursing Practice Projects

This project was developed with the aim of formulating an individualized educational packet that would improve patients’ knowledge of their initial cancer diagnosis and provide additional information to facilitate a smooth transition from treatment to remission. Using a pretest and posttest, quantitative data was collected pertaining to 10 different types of patient education. The pretest survey collected eight questions that related to gathering information about their cancer diagnosis, resources, and knowledge level. The DNP Project Leader secured a Cancer Survivorship Guide through the American Society of Clinical Oncology that was added to the initial cancer survivorship education for all patients. …

Molecularly Tracing Of Children Exposure Pathways To Environmental Persistent Organic Pollutants And The Autism Spectrum Disorder Risk, Nabigha Amen, Syed Ali Musstjab Akber Shah Eqani, Khawar Bilal, Nadeem Ali, Nisreen Rajeh, Dave Adelman, Heqing Shen, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

Organic pollutants (OPs) including organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and polycyclic aromatic hydrocarbons (PAHs) have showed neuro-damaging effects, but studies concerning the autism spectrum disorder (ASD) risk are limited. A case-control study with ASD (n=125) and healthy control (n=125) children was conducted on the different land use settings across Punjab, Pakistan. Serum concentrations of 26 OCPs, 29 PCB congeners, 11 PBDEs and 32 PAHs were measured. Serum PCB77 (AOR = 2.00; 95% CI: 1.43, 2.18), PCB118 (AOR = 1.49; 95% CI: 1.00, 2.00), PCB128 (AOR = 1.65; 95% CI: 1.01, 1.91), PCB153 (AOR = 1.80; …

A Decade Of Time Series Sampling Reveals Thermal Variation And Shifts In Pseudo-Nitzschia Species Composition That Contribute To Harmful Algal Blooms In An Eastern Us Estuary, Katherine M. Roche, Alexa R. Sterling, Tatiana A. Rynearson, Matthew Bertin, Bethany D. Jenkins

Graduate School of Oceanography Faculty Publications

In 2016-17, shellfish harvesting closed for the first time in Narragansett Bay, Rhode Island, USA, from domoic acid (DA), a neurotoxin produced by diatoms of the Pseudo-nitzschiagenus. Pseudo-nitzschia have occurred frequently for over 60 years in Narragansett Bay’s Long-Term Plankton Time Series (NBPTS), therefore it is surprising that the first closure only recently occurred. Pseudo-nitzschia species are known to vary in their toxin production, thus species identification is critical for understanding the underlying ecological causes of these harmful algal blooms (HABs). DNA in plankton biomass can be preserved for many years, so molecular barcoding of archived samples is useful …

Presence, Sources And Transport Of Polycyclic Aromatic Hydrocarbons In The Arctic Ocean, Lihong Zhang, Yuxin Ma, Simon Vojta, Maya Morales-Mcdevitt, Mario Hopggmann, Thomas Soltwedel, Jane Kirk, Amila De Silva, Derek Muir, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

Polycyclic aromatic hydrocarbons (PAHs) are continuously released from multiple sources and are prone to long-range transport. Little is known regarding their presence, transport and fate in remote and deep oceans. Polyethylene passive samplers were hence deployed at deep moorings and surface seawater in the Fram Strait and Canadian Archipelago, as well as in air and surface water of the lower Great Lakes, a potential high-emission region, to understand the transport of PAHs to the Arctic. Dissolved PAHs showed significantly higher concentrations in the lower Great Lakes than those in the high Arctic. Concentrations of dissolved PAHs (Σ₁₉PAHs) ranged …

Genome Assembly Of The Chemosynthetic Endosymbiont Of The Hydrothermal Vent Snail Alviniconcha Adamantis From The Mariana Arc, Corrina Breusing, Nathan Hagen Klobusnik, Michelle A. Hauer, Roxanne A. Beinart

Graduate School of Oceanography Faculty Publications

Chemosynthetic animal-microbe symbioses sustain hydrothermal vent communities in the global deep sea. In the Indo-Pacific Ocean, hydrothermal ecosystems are often dominated by gastropod species of the genus Alviniconcha, which live in association with chemosynthetic Gammaproteobacteria or Campylobacteria. While the symbiont genomes of most extant Alviniconcha species have been sequenced, no genome information is currently available for the gammaproteobacterial endosymbiont of Alviniconcha adamantis—a comparatively shallow living species that is thought to be the ancestor to all other present Alviniconcha lineages. Here, we report the first genome sequence for the symbiont of A. adamantis from the Chamorro Seamount at the …

Global 16s Rrna Diversity Of Provannid Snail Endosymbionts From Indo-Pacific Deep-Sea Hydrothermal Vents, Corinna Breusing, Jade Castel, Yi Yang, Thomas Broquet, Jin Sun, Didier Jollivet, Pei-Yuan Qian, Roxanne A. Beinart

Graduate School of Oceanography Faculty Publications

No abstract provided.

Preceptorship Practice In Healthcare Institutions In Ghana: A Situational Analysis, Ivy E. Sackey

Antioch University Dissertations & Theses

Preceptors play a vital role in supporting nursing/midwifery students and new employees’ transition and assimilation into their new role. Furthermore, with the increasing focus on educating more qualified nurses and midwives to meet health-related United Nations Sustainable Development Goals, there is a need for a more standardized and coordinated approach to preceptorship training. As former Head of the Nursing/Midwifery Training Institution in Ghana, I observed first-hand that the system of preceptorship needs improvements. Published literature on preceptorship has shown that the practice plays a vital role in healthcare delivery. However, most of the existing literature preceptorship is from developed countries, …

An Ambitious Vision For The Future Of Scientific Ocean Drilling, Paula Bontempi

Graduate School of Oceanography Faculty Publications

No abstract provided.

An Emerging Masculinity: A Qualitative Study Of Majority-Status Men's Gender Socialization, Emily Sargent

Antioch University Dissertations & Theses

Majority-status American men have been found to disproportionately experience suicide, homicide, perpetration of sexual assault and intimate partner violence, as well as, alcohol and drug-related concerns. Current research considers gender socialization of traditional constructs of masculinity to be “toxic” for men and others (i.e., Women, gender and sexual minorities). This study sought to explore young men’s current experience of masculinity identity development in America. Six participants who self-identified as White, straight, English speaking, educated, cisgender, and emerging adult men shared their lived experience of masculinity via virtual video interviews. To assess results of this qualitative study, interpretive phenomenological analysis was …

Black Parent Advocacy And Educational Success: Lessons Learned On The Use Of Voice And Engagement, Mark Mcmillian

Antioch University Dissertations & Theses

“The opportunity is there, this is what I think of when I think of role models, I think of my experience” (Anthony—a participant in this study—commenting on the effectiveness of advocating for his child). Black children encounter racism in American schools and parents need to advocate for them. The purpose of this qualitative study was to explore how Black parents developed and used their voice to advocate for their children in a predominantly White educational system with a history of racially disparate outcomes. Particularly, this study drew on the experiences of 15 participants, two men—one was a grandfather—and 13 women, …

The President's Welcome Address (2022 Intercultural Human Rights Law Review Symposium), David A. Armstrong

Intercultural Human Rights Law Review

President David A. Armstrong's welcome address for the 2022 Intercultural Human Rights Law Review Annual Symposium.

Session 1: The Death Penalty In The United States, Edith Georgi, Annemarie Harris Block, Hannah Gorman

Intercultural Human Rights Law Review

Session 1 of the 2022 Intercultural Human Rights Law Review Annual Symposium, entitled "The Death Penalty in the United States".

The Armenian Genocide, Customary International Law, And U.S. Recognition, Jordan Koopmans

Intercultural Human Rights Law Review

This article asserts that President Biden's statement recognizing the Armenian Genocide of 1915 illustrates that genocide was prohibited by customary international law when the genocide started. It examines possible legal theories to explain U.S. recognition as well as historical evidence and statements made by other states to establish that there is a strong case for genocide already outlawed by customary international law in 1915. This provides a foundation for the article's assertion and subsequent legal analysis of the United States' statements of recognition under a customary international law theory, concluding that this is the most likely legal theory the U.S. …