Digital Commons Network^™

How Valuable Are Clinical Neuropsychological Assessments? A Meta-Analysis Of Neuropsychological Tests With Comparison To Common Medical Tests And Treatments, Murphy N. Harrell

Graduate Theses and Dissertations (2019 - present)

There has been a general decrease in neuropsychological assessments at a time when medical diagnostic technology and treatments have expanded, leading to a faulty assumption that medical tests and healthcare treatments provide more reliable or valid data than psychological assessments. A landmark report from the American Psychological Association’s (APA) Psychological Assessment Work Group (PAWG) found that validity coefficients for many psychological tests were indistinguishable from those of medical tests (Meyer et al., 2001). An updated systematic review of the advancement in neuropsychological testing is essential to the continued advancement of the value of neuropsychological assessment in healthcare. This meta-analysis sought …

Neuropsychology Of Primary Headache Disorders: A Meta-Analysis, Jasmin H. Pizer

Graduate Theses and Dissertations (2019 - present)

Objective: A meta-analysis was conducted comparing cognition on clinical measures between individuals with a primary headache disorder (PHD) and healthy controls (HC). Data Selection: The University of South Alabama Libraries’ OneSearch and PubMed, with a uniform search-strategy, were used to locate original research comparing cognition between PHD and HC samples. Analyses were modeled under random effects. Hedge’s g was used as a bias-corrected estimate of effect size. Between-study heterogeneity was assessed using Cochran’s Q and I2. Data Synthesis: The initial search interval spanned inception–May 2021 and yielded 6692 results. Fifty-seven studies were analyzed. Meta-analysis showed a significant combined effect size …

Civil Litigation Notes (August 2022), Arthur S. Leonard

Other Publications

No abstract provided.

Biden Drops Trump’S Appeals Of Same-Sex Social Security Benefits, Arthur S. Leonard

Other Publications

No abstract provided.

11th Circuit Denies En Banc Review Of Panel Decision Enjoining Conversion Therapy Bans By Two Florida Localities, Arthur S. Leonard

Other Publications

No abstract provided.

Federal Judge Orders Indianapolis School To Let Transgender Girl Play On Softball Team, Arthur S. Leonard

Other Publications

No abstract provided.

Vasopressin Resets The Central Circadian Clock In A Manner Influenced By Sex And Vasoactive Intestinal Polypeptide Signaling, Kayla E. Rohr, Thomas Inda, Jennifer A. Evans

Biomedical Sciences Faculty Research and Publications

Background/Aims: Circadian rhythms in behavior and physiology are programmed by the suprachiasmatic nucleus (SCN) of the hypothalamus. A subset of SCN neurons produce the neuropeptide arginine vasopressin (AVP), but it remains unclear whether AVP signaling influences the SCN clock directly.

Methods: Here, we test that AVP signaling acting through V1A and V1B receptors influences molecular rhythms in SCN neurons. V1 receptor agonists were applied ex vivo to PERIOD2::LUCIFERASE SCN slices, allowing for real-time monitoring of changes in molecular clock function.

Results: V1A/B agonists reset the phase of the SCN molecular clock in a time-dependent manner, with larger magnitude responses by …

Determining The Full-Length Structure Of Collagenase H Using Small-Angle X-Ray Scattering, Josie Carson

Chemistry & Biochemistry Undergraduate Honors Theses

Known to cause gas gangrene, Hathewaya histolytica secretes two sister collagenases, collagenase G (Col G) and collagenase H (Col H), to degrade the triple helical structure of collagen to further infection in a host. Individual domains of Col H have been crystalized in previous studies, but methods in x-ray crystallization of full-length Col H have been unsuccessful. Using Small Angle X-Ray Scattering (SAXS) data, atomistic modeling was used to generate multiple conformations of Col H while accounting for flexibility between domains. Full-length Col H was found to adopt a two-state conformational model exhibiting a majority compact and a minority elongated …

Faculty Promotion Research Profile: Chenguang Fan, Lutishoor Salisbury, Fardy Faustin, Jeremy Smith

University Libraries Faculty Publications and Presentations

This poster was compiled to commemorate Dr. Fan’s promotion to Associate Professor with Tenure in the Department of the Chemistry and Biochemistry at the University of Arkansas, July 1, 2022. It provides a summary of his research achievements and his scholarly impact.

A Review Of Quantum Coherence And Its Effect On Photosynthetic Efficiency In Psii And Fmo Complexes, Matthew Nelson

Chemistry & Biochemistry Undergraduate Honors Theses

Photosynthesis in living organisms is one of the most efficient, natural energy harvesting processes on Earth. The absorption of light energy as photons directly energizes electrons in metabolite molecules. These molecules transfer their high energy electrons through a chain system to provide the energy needed for carbon dioxide metabolism. Recently, it has been a subject of debate how this energy transfer via electron transport achieved such high efficiency. One hypothesis is that this transfer system displays fundamentally quantum mechanical behaviors, such as coherence. Here, I will briefly define this concept in quantum mechanics, and explain the role it might play …

An Exploration Of Community Needs: The Lafayette County Foster Care System,, Meredith Mckissick

Honors Theses

Are there enough foster parents to meet the needs of our community? Who advocates on behalf of children who are in the custody of the state? What do children in custody need? Prior to this research, the general public was unable to find these answers in a concise and accessible manner. This study explores the community needs of the Lafayette County Foster Care System in Mississippi, through the means of a needs assessment. The assessment involves six interviews with local foster care leaders, collection and analysis of results, and formal recommendations. Findings are organized by both individual interviews and thematic …

Mediating And Maintaining Methylation While Minimizing Mutation: Recent Advances On Mammalian Dna Methyltransferases, Xiaodong Cheng, Robert M Blumenthal

Faculty, Staff and Student Publications

Mammalian genomes are methylated on carbon-5 of many cytosines, mostly in CpG dinucleotides. Methylation patterns are maintained during mitosis via DNMT1, and regulatory factors involved in processes that include histone modifications. Methylation in a sequence longer than CpG can influence the binding of sequence-specific transcription factors, thus affecting gene expression. 5-Methylcytosine deamination results in C-to-T transition. While some mutations are beneficial, most are not; so boosting C-to-T transitions can be dangerous. Given the role of DNMT3A in establishing de novo DNA methylation during development, it is this CpG methylation and deamination that provide the major mutagenic impetus in the DNMT3A …

Clinical Activity Of Mitogen-Activated Protein Kinase-Targeted Therapies In Patients With Non-V600 Braf-Mutant Tumors, Matthew Dankner, Yifan Wang, Rouhi Fazelzad, Benny Johnson, Caroline A Nebhan, Ibiayi Dagogo-Jack, Nathaniel J Myall, Georg Richtig, Jillian W P Bracht, Marco Gerlinger, Eiji Shinozaki, Takayuki Yoshino, Daisuke Kotani, Jason R Fangusaro, Oliver Gautschi, Julien Mazieres, Jeffrey A Sosman, Scott Kopetz, Vivek Subbiah, Michael A Davies, Anna L Groover, Ryan J Sullivan, Keith T Flaherty, Douglas B Johnson, Andrea Benedetti, David W Cescon, Anna Spreafico, George Zogopoulos, April A N Rose

Faculty, Staff and Student Publications

Purpose: Non-V600 mutations comprise approximately 35% of all BRAF mutations in cancer. Many of these mutations have been identified as oncogenic drivers and can be classified into three classes according to molecular characteristics. Consensus treatment strategies for class 2 and 3 BRAF mutations have not yet been established.

Methods: We performed a systematic review and meta-analysis with published reports of individual patients with cancer harboring class 2 or 3 BRAF mutations from 2010 to 2021, to assess treatment outcomes with US Food and Drug Administration-approved mitogen-activated protein kinase (MAPK) pathway targeted therapy (MAPK TT) according to BRAF class, cancer type, …

Selinexor In Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial, Mrinal M Gounder, Albiruni Abdul Razak, Neeta Somaiah, Sant Chawla, Javier Martin-Broto, Giovanni Grignani, Scott M Schuetze, Bruno Vincenzi, Andrew J Wagner, Bartosz Chmielowski, Robin L Jones, Richard F Riedel, Silvia Stacchiotti, Elizabeth T Loggers, Kristen N Ganjoo, Axel Le Cesne, Antoine Italiano, Xavier Garcia Del Muro, Melissa Burgess, Sophie Piperno-Neumann, Christopher Ryan, Mary F Mulcahy, Charles Forscher, Nicolas Penel, Scott Okuno, Anthony Elias, Lee Hartner, Tony Philip, Thierry Alcindor, Bernd Kasper, Peter Reichardt, Lore Lapeire, Jean-Yves Blay, Christine Chevreau, Claudia Maria Valverde Morales, Gary K Schwartz, James L Chen, Hari Deshpande, Elizabeth J Davis, Garth Nicholas, Stefan Gröschel, Helen Hatcher, Florence Duffaud, Antonio Casado Herráez, Roberto Diaz Beveridge, Giuseppe Badalamenti, Mikael Eriksson, Christian Meyer, Margaret Von Mehren, Brian A Van Tine, Katharina Götze, Filomena Mazzeo, Alexander Yakobson, Aviad Zick, Alexander Lee, Anna Estival Gonzalez, Andrea Napolitano, Mark A Dickson, Dayana Michel, Changting Meng, Lingling Li, Jianjun Liu, Osnat Ben-Shahar, Dane R Van Domelen, Christopher J Walker, Hua Chang, Yosef Landesman, Jatin J Shah, Sharon Shacham, Michael G Kauffman, Steven Attia

Faculty, Staff and Student Publications

Purpose: Antitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with selinexor. We evaluated the clinical benefit of selinexor in patients with previously treated DD-LPS whose sarcoma progressed on approved agents.

Methods: SEAL was a phase II-III, multicenter, randomized, double-blind, placebo-controlled study. Patients age 12 years or older with advanced DD-LPS who had received two-five lines of therapy were randomly assigned (2:1) to selinexor (60 mg) or placebo twice weekly in 6-week cycles (crossover permitted). The primary end point was progression-free survival (PFS). Patients who received at least one dose of …

Probing The Structure And Function Of Polymerase Θ Helicase-Like Domain, Scott Vanson, Yuzhen Li, Richard D Wood, Sylvie Doublié

Faculty, Staff and Student Publications

DNA Polymerase θ is the key actuator of the recently identified double-strand break repair pathway, theta-mediated end joining (TMEJ). It is the only known polymerase to have a 3-domain architecture containing an independently functional family A DNA polymerase tethered by a long central region to an N-terminal helicase-like domain (HLD). Full-length polymerase θ and the isolated HLD hydrolyze ATP in the presence of DNA, but no processive DNA duplex unwinding has been observed. Based on sequence and structure conservation, the HLD is classified as a member of helicase superfamily II and, more specifically, the Ski2-like family. The specific subdomain composition …

Your Health; Your Responsibility, Angel Sanders

Research Papers

Many believe racism doesn’t exist anymore. In fact, racism is still present, it’s evident in the black community when looking at health. Statistics show that black women specifically encounter more health issues than other races. This thesis touches on generational trauma, feminism, and health collectives. This is a tool for a person looking to heal themselves and start a new health journey. This research assures you don’t have to do this alone and is a step toward mitigation in the black community.

Chemiluminescence Of Platinum Nanoparticles Using A Green Method For Lateral Flow Immunoassay, Tiyesha Long

All Theses

Platinum (Pt) is used as a catalyst in many reactions, and platinum nanoparticles (Ptnps) are widely used in the biomedical industry as they show antioxidant, antimicrobial, and anticancer properties. Synthesis of Ptnps can be achieved in many ways. However, green synthesis methods are preferred over traditional ones as they minimize environmental pollution. This research aims to synthesize Ptnps using a green approach and use the synthesized nps in a catalysis reaction.

Nanoparticles were synthesized using chloroplatinic acid hydrate (H2PtCl6) and potassium hexachloroplatinate (IV) (K2PtCl6) and three types of milk obtained from the local grocery stores. The Pt salt and the …

Csd 110.01: Introduction To Speech, Language, And Audiology, Jennifer Katherine Schoffer-Closson

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Fabrication Of Lab-Scale Polymeric And Silicon Dioxide Nanoparticle-Enabled Thin Film Composite Reverse Osmosis Membranes For Potable Reuse Applications, Timothy J. Dinh

Master's Theses

Reverse osmosis (RO) is widely used for water reclamation and is one of the most feasible technologies for addressing water scarcity around the world. RO membrane fabrication procedures are continually being optimized and modified to enhance the treatment performance and efficacy of the RO process. A review of the existing literature published on membrane fabrication revealed that a detailed and reproducible methodology consistent among prior studies was not available. Therefore, the primary objective of this study was to utilize techniques from prior research to develop a reliable lab-scale membrane fabrication process for studying the potable reuse applications of TFC RO …

Strawberry Disease Management Improvement For Macrophomina Root Rot And Botrytis Fruit Rot, Yu-Chen Wang

Master's Theses

Strawberry production in California is limited by plant diseases such as Macrophomina root rot (caused by Macrophomina phaseolina) and Botrytis fruit rot (BFR) (caused by Botrytis cinerea). Current disease management strategies are compromised due to fumigant regulations or ineffective disease management practices. This thesis investigated methods to potentially improve the management of these two diseases.

Host plant resistance evaluations for Macrophomina root rot were conducted for the 2020-2021 and 2021-2022 growing seasons. Fifty-one strawberry genotypes were screened in two field experiments where plants were inoculated artificially with Macrophomina phaseolina in both seasons. A wide range of plant resistance …

Chronic Poetics: A Waiting Room Of One's Own, Madeleine Simmons

Electronic Theses, Projects, and Dissertations

This article explores chronic poetics, through my personal lens I take readers on a walk- through of poetry and the discussions surrounding chronic illnesses. I examine the current state of chronic illness and the nuances to its discussion. I analyze chronic illness in the context of disability studies, and touch on the tensions of categorizing chronic illness as a disability. As well as how to best navigate reading chronic poetics, as poets engage in new territories as they form a new language to describe their circumstances. While analyzing multiple poems from different authors, I explore why specifically the vessel of …

Early-Exercise Effects On Mice Tendon Remodeling, Miles Valencia

Electronic Theses, Projects, and Dissertations

Tendons connect and transmit energy between muscles and bones and play a key role in movement. Tendon remodels by breaking down and absorbing tendon components including collagen fibers and elastin while replacing them with newly formed tendon. These processes can be influenced by short- and long-term factors such as exercise and aging; the magnitude of influence on tendon remodeling remains unclear. I researched the effects of maturation and exercise on tendon remodeling using a mice colony artificially selected for high voluntary wheel running called high-runner mice. Control and high-runner linetype mice were separated into 2 age cohorts that started training …

Neonatal Islet-1+ Cardiovascular Progenitor Cell-Derived Exosomes And Their Functional Ability To Regulate Proliferation, Lourdes Ceja

Electronic Theses, Projects, and Dissertations

Heart failure affects many people around the world and can lead to disease progression and death. Consequently, new stem and exosome-based therapies are needed to address this major health issue and to provide therapeutic options that will improve outcomes for the increasing number of patients with heart disease. Stem cell-derived exosomes have captivated researchers’ attention over the past couple of years based on their functional role in cellular signaling which highlights the vital component of the secretome of stem and progenitor cells. Since neonates have significantly enhanced regenerative ability, we hypothesized that exosomes isolated from Islet-1+ expressing neonatal human cardiovascular …

Experiences Of Latina Student Mothers In The Transfer Pipeline: An Interpretive Phenomonological Analysis, Aurora Vilchis

Electronic Theses, Projects, and Dissertations

Characteristics of who today’s college student is has drastically changed over the years with more students over age 25, may have dependents, employed full-time, attending school part time and likely a parent. These students are known as post-traditional students who make up 85% of undergraduates nationwide. The purpose of this phenomenological study was to understand the experiences of Latina students, who are mothers, and have successfully transferred from a community college designated as a Hispanic Serving Institution (HSI) to a four-year public higher education institution also designated as an HSI. Data was collected from eleven participants who shared their experiences …

Ecological And Phenotypic Diversification After A Continental Invasion In Neotropical Freshwater Stingrays, Matthew Kolmann, Fernando Pl Marques, James C. Weaver, Mason N. Dean, Joao Pedro Fontenelle, Nathan R. Lovejoy

Faculty and Staff Scholarship

Habitat transitions are key potential explanations for why some lineages have diversified and others have not—from Anolis lizards to Darwin's finches. The ecological ramifications of marine-to-freshwater transitions for fishes suggest evolutionary contingency: some lineages maintain their ancestral niches in novel habitats (niche conservatism), whereas others alter their ecological role. However, few studies have considered phenotypic, ecological, and lineage diversification concurrently to explore this issue. Here, we investigated the macroevolutionary history of the taxonomically and ecologically diverse Neotropical freshwater river rays (subfamily Potamotrygoninae), which invaded and diversified in the Amazon and other South American rivers during the late Oligocene to early …

Perceptions Of Tenured Science Faculty Regarding The Provision Of Reasonable Accommodations For Students With Disabilities, Rebecca J. Riggs

Electronic Theses and Dissertations

This phenomenological study used qualitative research methods to explore the perceptions of tenured science faculty regarding the provision of reasonable accommodations for students with disabilities. Thirteen tenured science faculty at postsecondary institutions throughout the United States participated in one-on-one interviews. The participants provided their perceptions and experiences regarding the provision of academic accommodations for students with disabilities in a laboratory science. In these interviews key themes emerged, such as the importance of providing reasonable accommodations for successful academic outcomes for students with disabilities, the perception that providing reasonable accommodations to students with disabilities is fair, the concern that providing reasonable …

The Role Of Microbiota On Campylobacter Jejuni Colonization And Growth Performance In Broiler Chickens, Ayidh Almansour

Graduate Theses and Dissertations

The successful poultry production at modern era comes from the vertical integratedindustrialization, which has fundamentally changed how animals have been living for millions of years. Antimicrobial growth promoters have been used to sustain the efficient industrialized animal production, driving antimicrobial overuse and resistance. Because of the increasing pressure from consumer’s concerns and government regulations, it is urgent to develop antimicrobial free alternatives as growth promoters in poultry production, but few effective antimicrobial alternatives are currently available. Campylobacter jejuni is one of the worldwide prevalent foodborne bacterial pathogens mainly transmitted from poultry. However, few mechanisms are available on why C. jejuni …

Silymarin And Oral Cancer: A Review On Clinical And Analytical Reports, Ramya Jonnalagadda, C. Vinodhini

The Thai Journal of Pharmaceutical Sciences

Oral cancer is the sixth-largest kind globally of cancer and a major health issue in India as well and affects a large population that is very vulnerable to recurrences and a lower survival rate among all the other malignancies. Milk thistle is a phytochemical herb of interest that has been used as folk medicine since ancient times. Due to its potential benefits, the pharmaceutical industrial world is widely using silymarin (an active component of milk thistle) for commercial preparations. Knowing the quantity and identity of active components is of utmost importance. Therefore, robust, accurate, and precise analytical methods are needed …

Project-Based Learning In Introductory Psychology: Modern Adaptations To An Academic Classic, Colton R. Olson

Dissertations

This study used a quasi-experimental design to examine the effectiveness of a project-based learning (PjBL) course design on meaningful learning, student goal orientation, engagement, and perceived classroom motivational climate in an introductory psychology course. Project-based learning was examined in comparison to a traditional, lecture and multiple-choice exam course design in introductory psychology over the course of one semester (N = 247). Generally, there is limited research examining PjBL in large introductory classes, specifically in relation to concrete outcomes such as meaningful learning and perceived classroom climate (Gurung et al., 2016). Therefore, the purpose of the study was to add to …

Getting Them To The Chopper: An Empirical Study Of Man Therapy, A Public Health Campaign Designed To Encourage Men To Utilize Psychological Services, David Gretz

Dissertations

This study examined the effects that the Man Therapy website may have on men’s attitudes and intentions toward seeking professional psychological services, factors that play a role in deciding if they will eventually engage in the behavior of seeking of professional psychological services according to the theory of planned behavior. A large number of men die by suicide every year, and many men struggle with mental health concerns. Various components of masculinities can serve as barriers that dissuade men from seeking treatment for these concerns. Man Therapy is a novel approach that attempts to better engage men with professional psychological …