Digital Commons Network^™

A Large-Scale Genome-Wide Gene-Gene Interaction Study Of Lung Cancer Susceptibility In Europeans With A Trans-Ethnic Validation In Asians, Ruyang Zhang, Sipeng Shen, Yongyue Wei, Ying Zhu, Yi Li, Jiajin Chen, Jinxing Guan, Zoucheng Pan, Yuzhuo Wang, Meng Zhu, Junxing Xie, Xiangjun Xiao, Dakai Zhu, Yafang Li, Demetrios Albanes, Maria Teresa Landi, Neil E Caporaso, Stephen Lam, Adonina Tardon, Chu Chen, Stig E Bojesen, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, Gadi Rennert, Susanne Arnold, Paul Brennan, James D Mckay, John K Field, Sanjay S Shete, Loic Le Marchand, Geoffrey Liu, Angeline S Andrew, Lambertus A Kiemeney, Shan Zienolddiny-Narui, Annelie Behndig, Mikael Johansson, Angela Cox, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Juncheng Dai, Hongxia Ma, Yang Zhao, Zhibin Hu, Rayjean J Hung, Christopher I Amos, Hongbing Shen, Feng Chen, David C Christiani

Faculty, Staff and Students Publications

INTRODUCTION: Although genome-wide association studies have been conducted to investigate genetic variation of lung tumorigenesis, little is known about gene-gene (G × G) interactions that may influence the risk of non-small cell lung cancer (NSCLC).

METHODS: Leveraging a total of 445,221 European-descent participants from the International Lung Cancer Consortium OncoArray project, Transdisciplinary Research in Cancer of the Lung and UK Biobank, we performed a large-scale genome-wide G × G interaction study on European NSCLC risk by a series of analyses. First, we used BiForce to evaluate and rank more than 58 billion G × G interactions from 340,958 single-nucleotide polymorphisms …

A Comparison Of Uniaxial Compressive Response And Inelastic Deformation Mechanisms In Freeze Cast Alumina-Epoxy Composites Without And With Rigid Confinement, Tareq Aljuhari

Mechanical & Aerospace Engineering Theses & Dissertations

Cellular ceramics have an array of improved mechanical properties that make them incredibly desired for different applications such as armor systems, aircraft structures, automobiles bumpers, and biomedical implants. It is also desirable that porous architecture could be shaped into bulk complicated shapes and easy to scale-up with low manufacturing cost. Despite several efficient techniques to fabricate cellular ceramics, some limitations are preventing us from meeting the high demand of the after mentioned applications. For that, freeze casting, also called ice-templating, is technique of solidifying an aqueous ceramic suspension under the effect of unidirectional temperature gradient. In this study, Ice-templated porous …

Testing A Contextual Framework Of Intimate Partner Violence In Young Adults, Phoebe Tabb Hitson

Psychology Theses & Dissertations

Bell and Naugle (2008) proposed a comprehensive theoretical framework that includes multiple variables hypothesized to be involved in intimate partner violence (IPV) perpetration, including distal and proximal variables. The current study (1) assessed the extent to which childhood physical abuse victimization, interparental violence, insecure attachment, accepting beliefs about violence, sexism, stress, alcohol and marijuana use, relationship satisfaction, emotion regulation, and anger management were associated with physical IPV perpetration; (2) determined whether some of these variables influenced physical IPV perpetration more than others; (3) explored the mediation of distal variables by more proximal variables in predicting physical IPV perpetration; and (4) …

A Comparison Of Sorority Women And Non-Sorority Women’S Alcohol Use: Perception, Rate Of Use, And Consequences, Betsy Zimmerman

Counseling & Human Services Theses & Dissertations

While alcohol use and Greek Life on college campuses have often become synonymous, little is known about the rate of use or the consequences of use for sorority women specifically. Gender has been identified as a risk factor relating to substance use on college campuses; however, there is a gap in the literature concerning compounding factors that influence substance abuse, such as membership in a Greek-lettered organization. With approximately 300,000 college women involved in Greek-lettered organizations annually (NPC, 2019), little is known about the impact of alcohol use for sorority women on college adjustment. An exploration of the perception of …

"I Want To Know What I'M Looking At": Surveilling Gender As A Response To Cultural Anxieties In Halloween, Sleepaway Camp, And Scream, Jennifer Jacinda Mclawhorn

Institute for the Humanities Theses

The purpose of this thesis is to investigate slasher films and how they use gendered tropes to respond to and perpetuate cultural anxieties. The methodology primarily uses textual analysis that includes close attention to content, context, and discourse. The study reveals structural patterns and problems that emerge within slasher films, specifically within the Final Girl trope and the behaviors that govern it. In surveilling the Final Girl’s gender performativity, it is apparent that abjection, or a gut reaction to something that exists between two distinct boundaries or categories, is provoked when the Final Girl crosses a socially established gender boundary. …

Mental Health Counselors’ Perceptions Of Professional Identity As Correctional Counselors In An Integrated Behavioral Health Care Setting, Jeanel L. Franklin

Counseling & Human Services Theses & Dissertations

This study explores the professional identity of clinical mental health counselors employed as correctional counselors in an integrated behavioral health (IBH) setting. Previous research has documented the attitudes, perceptions, and experiences of mental health counselors working in IBH as well as their experiences engaging in interprofessional collaboration. However, researchers have yet to explore how clinical mental health counselors in correctional settings perceive their professional identity and what aspects of their professional roles impact their identity development. This study utilized an interpretive phenomenological approach (IPA) to describe, understand, and interpret the meaning of four correctional counselors’ perceptions of their professional identities …

Accommodations, Inclusion, And Communication With Students With Disabilities In The Music Classroom, Cora M. Wilson

Music Theses & Dissertations

The purpose of this study was to learn how music educators create inclusivity in their classroom and how to better do that without potentially alienating the students with disabilities. For this study, inclusivity is defined as providing an equal opportunity for participation and education in the classroom. It is also to bring more awareness to disabilities and how they can and should be managed in the classroom. The goal for this study is to aid in informing educators on how to enable students with disabilities to be included without feeling alienated or having undue attention drawn to them.

As the …

Examining The Culturally Responsive Teaching Self-Efficacy Of Teacher Candidates In Urban Immersive Residency Programs, Latanya M. Sutphin

Teaching & Learning Theses & Dissertations

Urban immersive residency programs have emerged from partnerships between K-12 schools and universities offering teacher candidates a year-long field experience alongside coursework aligned with the framework and practices in the schools (Zeichner & Bier, 2015). The goals of these programs include teacher candidates applying what they learn during preparation into practice and getting good student outcomes, while building their confidence in teaching diverse students. This study used situated learning theory (Lave & Wenger, 1991) to position urban immersive residency programs as a community of practice where teacher candidate’s self-efficacy and understanding of culturally responsive teaching overlap. A mixed methods design …

Clostridioides Difficile Biofilm And Spore Production In Response To Antibiotics And Immune Stress, Adenrele M. Oludiran

Chemistry & Biochemistry Theses & Dissertations

The development of new therapeutic options against Clostridioides difficile (C. difficile) infection is a critical public health concern, as the causative bacterium is highly resistant to multiple classes of antibiotics. C. difficile, an anaerobic spore-forming Gram-positive pathogenic bacterium, is a major cause of hospital-acquired infections. C. difficile persists in the environment and spreads the infection to new hosts in the form of dormant spores and can persist within hosts as surface-attached biofilms. These studies investigate bacterial vegetative cell survival, biofilm formation, and sporulation in response to stress. Antimicrobial host-defense peptides (HDPs) are highly effective at simultaneously modulating …

Nestedness And Modularity Of Avian Metacommunities Across Gradients Of Chesapeake Bay Island Characteristics, Grant Walter Bowers

Biological Sciences Theses & Dissertations

Islands are not only great models for understanding the ways in which communities are linked by the dispersal of their members to form metacommunities, but are of particular interest to conservationists. One important aspect of metacommunity structure is the degree of nestedness—whether or not less speciose communities are perfect subsets of more speciose communities. Another important metric of metacommunity structure is modularity—the degree to which communities belong to modules composed of other communities that share the same species but have little species overlap with communities from different modules. Environmental gradients have received insufficient attention as predictors of metacommunity nestedness and …

The Influences Of Disperser Behavior, Host Availability, And Environmental Conditions On The Distribution Of Oak Mistletoe [Phoradendron Leucarpum (Raf.) Reveal & M. C. Johnst.] In Eastern Virginia And North Carolina, Nicholas Pearce Flanders

Biological Sciences Theses & Dissertations

Mistletoes are shrubs that typically parasitize the branches of host trees and rely on avian frugivores for seed dispersal. Because mistletoes are restricted to a narrow range of suitable recruitment sites and avian frugivores are more visible than other guilds of seed dispersers, mistletoe-frugivore systems afford opportunities for assessing the roles of dispersal limitation and local environment in determining plant distribution. These mechanisms have been proposed as determinants of the observed association of oak mistletoe [Phoradendron leucarpum (Raf.) Reveal & M. C. Johnst.] with forested wetlands in eastern Virginia and North Carolina, USA. I tested the alternative hypothesis that …

Study The Effect Of Harmful Radiation On Patients, Eyes From 15-25 Years During Using Smart Devices, Mundher Sameen Shuker, Zina Tariq Ali

Al-Nisour Journal for Medical Sciences

The aim of this study was to assess the unsafe effects of harmful radiation, especially blue light and ultraviolet rays on patients' eyes aged (15-25) years during us exposure. It was carried out at the optics consulting clinic of the College of Health and Medical Technology in Baghdad/Iraq. In this research, (50) patients were enrolled, 28 males and 22 females, with their ages ranging from (15- 25) years. The smart devices are used by all patients for 2 to 5 hours daily. The majority of the patients were middle school and university students, accounting for 94 % of the patient …

Estimation Of Oxidative Stress, Oxidized Ldl And Some Trace Element In Type 2 Diabetes Mellitus, Noor Kareem Abbas, Ahmed A. Mohsin, Humiash H. H., Muhammed M. Radhi

Al-Nisour Journal for Medical Sciences

Oxidative stress is a physiological state in which high numbers of reactive oxygen species (ROS) and free radicals are produced. It has been demonstrated that oxidative stress plays a role in the development of diabetes. We aimed in this study to assists oxidative stress markers in diabetic patients, such as the oxidation-reduction process and OxLDL, as well as the relationship between OxLDL and the traditional risk factors for type 2 diabetes (LDL, FBS). In addition, various trace metals (copper, zinc, and chromium) were evaluated as antioxidants. The study was conducted at the Specialized Center for Endocrinology and Diabetes in Babylon …

Evaluation Iron (Fe) And Lad (Pb) Effect On Diabetes Mellitus2 Patients In Erbil Governorate, Ahmed Sa’Adi Hassan

Al-Nisour Journal for Medical Sciences

Diabetes mellitus (DM) is a complex, chronic illness requiring continuous medical care with multifactorial risk-reduction strategies beyond glycemic control to preventing acute complications and reducing the risk of long-term complications. Therefore, Iraq is one of the 19 countries and territories of the International Diabetes Federation (IDF)The target of present work is to study some cases of people evaluation Iron (Fe) and led (Pb) effect on DM2 patients in Erbil governorate lead was estimated by using Flam atomic absorption spectrophotometry (FAAS) and the estimation of iron by used randox manual kit, while the grafite Furnace Atomic Absorption Spectrophotometry (GFAAS) was used …

Polymorphism With Bladder Cancer Risk And Staging, Saleh Ali Al-Qadoori, Farah A. Dawood

Al-Nisour Journal for Medical Sciences

Telomerase-associated protein 1 is responsible ribonucleoprotein complex for telomerase activity, which catalyzes new telomeres on the chromosome ends. The presented work studied the impact of (TEP1) single nucleotide polymorphism on bladder CA risk. A total of sixty-two diagnosed by histopathologically with Transitional cell carcinoma (TCC) individuals and thirty-eight individuals as controls were implicated in the research. TEP1 rs222804 Polymorphism (C>T) was estimated by amplifying the gene with PCR and DNA sequencing methods. This study revealed that the polymorphic T allele related to TEP1 rs222804 Polymorphism has a considerable association in increase TCC risk with an odds ratio of 4.7. …

Client’S Satisfaction Regarding Immunization Program Services Of Children Under 5 Years In Al- Diwaniyah Governorate, Iraq, Fadel Mohammed Jasem, Ali Hussein Al-Hafidh

Al-Nisour Journal for Medical Sciences

Immunization against infectious diseases is one of the most successful public health interventions; it is safe and economically feasible. The aim of the vaccination process is to prevent disability and death resulting from diseases that can be prevented by vaccines. Smallpox was completely eradicated in the previous period using vaccination programs, and now the world is close to eradicating polio. To evaluate the client’s satisfaction with the services of the expanded program of immunization in Diwaniyah governorate / Iraq. Cross-sectional descriptive study and included a random sample of clients consisting of 420 caregivers (mothers, fathers, and relatives of children) were …

Study The Effects Of Sleeve Gastroectomy On Il-8, Il-18, And Vitamin D3 Deficiencies, Mohammed Abbas Fadil, Raya Ezat Maroof, Moayed Abbas

Al-Nisour Journal for Medical Sciences

Bariatric surgery is the most successful therapy for weight loss, Sleeve gastrectomy; part of the stomach is removed, reducing its capacity by about 85%. Reducing stomach size decreases the consumption of food. Obesity is measured based on their BMI, an estimate of body fat based on weight and height is to study the association between sleeve gastroectomy and some immune marker by estimation level of interleukin-8 (IL-8), interleukin-18 (IL-18), and vitamin D3 in sera patient and control groups, to determination the correlation between in markers; Body mass index (BMI) and their parameters. A total of thirty blood samples were obtained …

Instructional Designers Conducting Professional Learning Using Social Media: A Phenomenological Study Of Their Experiences Through A Self-Regulated Learning Lens, Pauline S. Muljana

STEMPS Theses & Dissertations

Because the instructional design and technology field is dynamic (Sharif & Cho, 2015; Wang et al., 2021), instructional designers need to pursue continuous, just-in-time professional learning (Carliner, 2018) to improve knowledge, skills, and abilities (Sharif & Cho, 2015; Ritzhaupt & Martin, 2015), without being constrained by location, budget, and time (Muljana et al., 2020; Muljana et al., 2021). On the one hand, the omnipresent social media technologies offer affordances for facilitating this type of professional learning. Such technologies allow instructional designers to reach out to colleagues, search for ready-to-implement strategies, and find relevant, timely information. On the other hand, conducting …

Fabrication And Characterization Of Dna Templated Electronic Nanomaterials And Their Directed Placement By Self-Assembly Of Block Copolymers, Dulashani Ruwanthika Ranasinghe Weerakkodige

Theses and Dissertations

Bottom-up self-assembly has the potential to fabricate nanostructures with advanced electrical features. DNA templates have been used to enable such self-assembling methods due to their versatility and compatibility with various nanomaterials. This dissertation describes research to advance several different steps of biotemplated nanofabrication, from DNA assembly to characterization. I assembled different nanomaterials including surfactant-coated Au nanorods, DNA-linked Au nanorods and Pd nanoparticles on DNA nanotubes ~10 micrometer long, and on ~400 nm long bar-shaped DNA origami templates. I optimized seeding by changing the surfactant and magnesium ion concentrations in the seeding solution. After successful seeding, I performed electroless plating on …

The Influence Of Chemistry Instructors’ Knowledge And Beliefs About Learning On The Implementation Of Evidence-Based Instructional Practices, Brittney J. Morgan

Dissertations

In this dissertation I explore characteristics which influence the implementation of evidence-based instructional practices of six post-secondary chemistry instructors in Colorado who report current use of these practices. The purpose of this study was to identify these characteristics to recognize areas of focus for future professional development. Knowledge and beliefs were also explored, as characteristics are often a culmination of these individual beliefs. Using a qualitative case study approach, a survey, classroom observations, and semi-structured interviews were used to collect the data for this exploration. Instructors were observed using the Classroom Observation Protocol for Undergraduate Science, Technology, Engineering and Math …

Examining The Effect Of Gratitude On Intolerance Of Uncertainty And Loneliness, Adam John Paul Mackenzie

Dissertations

Loneliness has been demonstrated to have significant negative effects on overall well-being in the general population. Previous literature has demonstrated a significant association between loneliness and various demographic variables such as gender, age, educational attainment, relationship status, living arrangements and income. Because of the unique impact that the disease caused by the coronavirus, COVID–19, has had on a global scale in relation to physical distancing and increasing physical and psychological distress, the purpose of this study was to examine the role that gratitude played in the relationship between intolerance of uncertainty and loneliness among the general adult population of the …

Mathematical Knowledge For Teaching In Co-Teachers At The Post-Secondary Level: A Cognitive And Enacted Approach, Lida Marie Lavelle Bentz

Dissertations

Mathematical Knowledge for Teaching (MKT), the knowledge used by a teacher to teach mathematics, has often been examined as a cognitive construct in K-6 teachers, but little research exists examining MKT in the post-secondary teaching context. Schoenfeld (2020) extended the definition of knowledge and thus MKT to include tacit and explicit perceptions. In doing so, Schoenfeld created the terms "big K" mKt and "little k" mkt, where mKt refers to the tacit and explicit perceptions used by a teacher to teach mathematics and mkt includes the teacher's understanding used in teaching mathematics (similar to cognitive MKT). Building from Schoenfeld’s conceptualization …

Clemson Commencement Program, August 2022, Clemson University

Clemson Commencement Programs

No abstract provided.

Covid-19 And Cardiac Injury: A Complex Interplay, Muenpetch Muenkaew

Asian Medical Journal and Alternative Medicine

Although the coronavirus disease-2019 (COVID-19) primarily affects the respiratory system, the cardiovascular system is the potential target since angiotensin-converting enzyme 2 (ACE2), which acts as a receptor for the virus, is also extensively expressed in the myocardium. A large proportion of individuals infected with COVID-19 have prior cardiac risk factors in which hypertension and diabetes are the most prevalent comorbidities. Cardiac injury, defined as an elevated cardiac troponin, is the most reported cardiac abnormality in COVID-19. Acute cardiac injury can occur through a number of possible mechanisms include: (1) Non-ischemic myocardial injury related to various causes e.g., systemic inflammation, cytokine …

Look, But Don’T Touch: Impact Of Covid-19 On The Nicu Caregiver, Rebecca C. Otwell-Dove

Electronic Theses and Dissertations

Admission of an infant into the neonatal intensive care unit (NICU) is an experience that has been associated with a variety of both positive and negative health outcomes for parent and child. While both the setting name and the admitted population alludes to a sole focus on the affected infant, what often remains underrecognized is the impact on the ones who care for the newborn long before and longer after their NICU stay. Given the recency and unprecedented impact of the COVID-19 pandemic, very little research has examined the impact of COVID-19-specific stress on the experience of parents of infants …

Evaluating Bat Roost Abundance: A Comparison Of Drone-Acquired Thermal Imagery And Acoustic Estimates With Visual Observations, Karah Jaffe

Electronic Theses and Dissertations

Roosts provide an opportunity to census philopatric populations of bats. Comparing the efficacy of traditional methods with novel methods can provide guidance on the use of new technologies in the field. This project aims to compare the count efficacy of external emergence methodologies, i.e., drone-acquired thermal imagery, acoustic estimates, and visual counts. Surveys were conducted ten nights at two emergence sites and synchronized to compare counts. Acoustic estimates could not be established as there was a weak prediction of the linear relationship between root-mean-square pressure and emergence count; therefore, this method was removed from the comparative analysis. A linear mixed-effects …

Adaptation Of Instructional Strategies And Practices During A Pandemic, Lacy E. York Hughes

Electronic Theses and Dissertations

The purpose of this study was to explore the stories of identified, effective middle school teachers as they experienced changes in instructional strategies and practices as a result of an identified crisis, COVID-19. Although there has been little documentation in the literature specifically regarding adapting instructional strategies and practices as a result of crises, crisis management, change theory, mindset theory, adaptation, and teacher effectiveness characteristics became the framework through which to interpret the data.

Data collection strategies included one-on-one, semi-structured interviews with a total of eight participants, two principals and six teachers, who met specific research participation criteria. Analysis of …

Validation Of The 40 Hz Auditory Steady State Response As A Pharmacodynamic Biomarker Of Evoked Neural Synchrony, Muhammad Ummear Raza

Electronic Theses and Dissertations

Schizophrenia is a troubling and severe mental illness that is only incompletely treated by currently available drugs. New drug development is hindered by a scarcity of functionally relevant pharmacodynamic biomarkers that are translatable across preclinical and human subjects. Although psychosis is a major feature of schizophrenia, cognitive and negative symptoms determine the long-term functional outcomes for patients. Stimulus-evoked neural synchrony at gamma (~ 40 Hz) frequency plays an important role in the processing and integration of sensory information. Not surprisingly, schizophrenia patients show deficits in gamma oscillations. NMDA receptor (NMDAR) activation on fast-spiking parvalbumin-positive interneurons is deemed important for the …

Adverse Childhood Experiences And Quality Of Life: A Mediating Role Of Physical Activity And Executive Function, Loni Parrish

Electronic Theses and Dissertations

ACEs have been associated with heightened risk for a range of chronic health problems, substance use, and cognition in adulthood (Center for Disease Control (CDC), 2019; Hinojosa et al., 2017). One potential protective factor is physical activity (McEwen, 2016; Wu et al., 2013). Physical activity is associated with sustaining overall health, improving mental health by reducing symptoms of depression and anxiety (Murri et al., 2019; Sharma et al., 2006; Tasci et al., 2019), and maintaining a healthy body weight and BMI (WHO, 2021). Therefore, this study examined whether barriers to physical activity, physical activity levels, and executive outcomes serve as …

The Paleoecology Of High-Elevation Bison In The Greater Yellowstone Ecosystem And Implications For Modern Bison Conservation, Darian Bouvier

Electronic Theses and Dissertations

The national mammal of the United States, the American Bison (Bison bison) was once nearly extinct. Populations have recovered to the degree that thousands roam the Great Plains today. Due to their large numbers and body size, this species has an oversized impact on the ecological communities where it lives and is considered a keystone herbivore in modern North American grasslands. This study explores the detailed, seasonally resolved, paleoecology of seven bison from the Greater Yellowstone Ecosystem during the Late Holocene through stable isotope analyses and species niche modeling. Isotopic analyses of δ¹³C, δ¹⁵N, …